GNAI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.89322801
2cullin deneddylation (GO:0010388)4.68117943
3protein deneddylation (GO:0000338)4.30856596
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.10236175
5regulation of mitotic spindle checkpoint (GO:1903504)4.10236175
6CENP-A containing nucleosome assembly (GO:0034080)4.05735511
7chromatin remodeling at centromere (GO:0031055)4.01872950
8neural tube formation (GO:0001841)4.00938879
9proteasome assembly (GO:0043248)3.75984662
10COPI coating of Golgi vesicle (GO:0048205)3.61735446
11Golgi transport vesicle coating (GO:0048200)3.61735446
12non-recombinational repair (GO:0000726)3.50576785
13double-strand break repair via nonhomologous end joining (GO:0006303)3.50576785
14prenylation (GO:0097354)3.45140837
15protein prenylation (GO:0018342)3.45140837
16spindle checkpoint (GO:0031577)3.42971821
17DNA catabolic process, exonucleolytic (GO:0000738)3.42490175
18regulation of centriole replication (GO:0046599)3.41385435
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.39584938
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.39584938
21histone H2A acetylation (GO:0043968)3.39553743
22RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.37867723
23histone exchange (GO:0043486)3.33801546
24response to X-ray (GO:0010165)3.32192080
25postreplication repair (GO:0006301)3.31084012
26replication fork processing (GO:0031297)3.30998559
27recombinational repair (GO:0000725)3.29281731
28protein heterotetramerization (GO:0051290)3.24275853
29double-strand break repair via homologous recombination (GO:0000724)3.24091313
30somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.23476619
31somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.23476619
32isotype switching (GO:0045190)3.23476619
33DNA unwinding involved in DNA replication (GO:0006268)3.23266700
34mitotic spindle checkpoint (GO:0071174)3.22966499
35centriole replication (GO:0007099)3.18357498
36negative regulation of DNA recombination (GO:0045910)3.14150651
37nuclear pore complex assembly (GO:0051292)3.10418377
38antigen processing and presentation of endogenous antigen (GO:0019883)3.07936193
39signal peptide processing (GO:0006465)3.07682427
40DNA replication-independent nucleosome assembly (GO:0006336)3.02929189
41DNA replication-independent nucleosome organization (GO:0034724)3.02929189
42DNA ligation (GO:0006266)3.01384256
43ribonucleoprotein complex disassembly (GO:0032988)3.00286307
44DNA replication-dependent nucleosome organization (GO:0034723)2.98896581
45DNA replication-dependent nucleosome assembly (GO:0006335)2.98896581
46folic acid-containing compound biosynthetic process (GO:0009396)2.98175097
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.98139848
48regulation of helicase activity (GO:0051095)2.97042945
49nuclear pore organization (GO:0006999)2.96854910
50negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96503898
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96503898
52negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96503898
53negative regulation of mitotic sister chromatid separation (GO:2000816)2.96503898
54negative regulation of sister chromatid segregation (GO:0033046)2.96503898
55somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94674562
56somatic hypermutation of immunoglobulin genes (GO:0016446)2.94674562
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.94665269
58Arp2/3 complex-mediated actin nucleation (GO:0034314)2.94479551
59regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92973005
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92973005
61hepatocyte apoptotic process (GO:0097284)2.92486093
62organelle disassembly (GO:1903008)2.90522995
63spindle assembly checkpoint (GO:0071173)2.89553064
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88056045
65mitotic spindle assembly checkpoint (GO:0007094)2.88046844
66negative regulation of chromosome segregation (GO:0051985)2.87726896
67regulation of cofactor metabolic process (GO:0051193)2.87047146
68regulation of coenzyme metabolic process (GO:0051196)2.87047146
69exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86347631
70histone mRNA metabolic process (GO:0008334)2.84667697
71DNA replication checkpoint (GO:0000076)2.84439368
72sister chromatid segregation (GO:0000819)2.83149800
73mitotic sister chromatid segregation (GO:0000070)2.82092804
74ribosome assembly (GO:0042255)2.81138890
75regulation of sister chromatid segregation (GO:0033045)2.80353840
76regulation of mitotic sister chromatid separation (GO:0010965)2.80353840
77regulation of mitotic sister chromatid segregation (GO:0033047)2.80353840
78protein K11-linked ubiquitination (GO:0070979)2.79465395
79regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79032118
80regulation of acyl-CoA biosynthetic process (GO:0050812)2.77814801
81microtubule anchoring (GO:0034453)2.77624630
82platelet dense granule organization (GO:0060155)2.76363365
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74799921
84protein K11-linked deubiquitination (GO:0035871)2.74717074
85regulation of centrosome duplication (GO:0010824)2.74025922
86double-strand break repair (GO:0006302)2.72511977
87antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71830669
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70978987
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70978987
90protein localization to kinetochore (GO:0034501)2.68916834
91purine nucleobase biosynthetic process (GO:0009113)2.68812445
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.63981287
93negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63167235
94regulation of DNA endoreduplication (GO:0032875)2.58044039
95regulation of centrosome cycle (GO:0046605)2.57313363
96cilium morphogenesis (GO:0060271)2.56568885
97positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56217692
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.56002611
99regulation of chromosome segregation (GO:0051983)2.55475652
100regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.54922760
101nucleobase biosynthetic process (GO:0046112)2.54836904
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.54547480
103pore complex assembly (GO:0046931)2.45845436
104mitotic chromosome condensation (GO:0007076)2.45668043
105mitotic nuclear envelope disassembly (GO:0007077)2.43218373
106regulation of spindle organization (GO:0090224)2.40938112
107nuclear envelope disassembly (GO:0051081)2.32258633
108membrane disassembly (GO:0030397)2.32258633
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.31056726
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.31056726
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.31056726
112negative regulation of phagocytosis (GO:0050765)2.29367410
113production of molecular mediator involved in inflammatory response (GO:0002532)2.25948743
114positive regulation of natural killer cell differentiation (GO:0032825)2.22077323
115positive regulation of protein import into nucleus, translocation (GO:0033160)2.20997334
116maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.20840308
117COPII vesicle coating (GO:0048208)2.20016297
118histone-serine phosphorylation (GO:0035404)2.18250958
119regulation of interleukin-12 biosynthetic process (GO:0045075)2.18007361
120germ cell migration (GO:0008354)2.17534734
121DNA topological change (GO:0006265)2.16975932
122growth hormone receptor signaling pathway (GO:0060396)2.16943409
123IMP biosynthetic process (GO:0006188)2.16318565
124regulation of natural killer cell differentiation (GO:0032823)2.13312095
125positive regulation of gamma-delta T cell activation (GO:0046645)2.11226309
126protein localization to chromosome, centromeric region (GO:0071459)2.09940020
1273-UTR-mediated mRNA stabilization (GO:0070935)2.09936614
128mitotic sister chromatid cohesion (GO:0007064)2.09427087
129ribosomal small subunit assembly (GO:0000028)2.09197707
130formation of translation preinitiation complex (GO:0001731)2.08264922
131actin nucleation (GO:0045010)2.06596577
132regulation of RNA export from nucleus (GO:0046831)2.05907044
133IMP metabolic process (GO:0046040)2.05400025
134sequestering of metal ion (GO:0051238)2.05145253
135neutrophil activation involved in immune response (GO:0002283)2.04621289
136regulation of sister chromatid cohesion (GO:0007063)2.04364554
137antigen processing and presentation via MHC class Ib (GO:0002475)2.04163888
138positive regulation of chromosome segregation (GO:0051984)2.03882919
139leukocyte aggregation (GO:0070486)2.03170781
140endothelial tube morphogenesis (GO:0061154)2.02828432
141morphogenesis of an endothelium (GO:0003159)2.02828432
142T cell apoptotic process (GO:0070231)2.02707286
143DNA duplex unwinding (GO:0032508)2.02450388
144low-density lipoprotein particle clearance (GO:0034383)2.02432836
145regulation of gamma-delta T cell differentiation (GO:0045586)2.01728389
146positive regulation of interferon-alpha production (GO:0032727)2.01707286
147pentose-phosphate shunt (GO:0006098)1.99831371
148DNA geometric change (GO:0032392)1.99420196
149glucocorticoid receptor signaling pathway (GO:0042921)1.99020373
150NADPH regeneration (GO:0006740)1.97519701
151JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.96287296
152corticosteroid receptor signaling pathway (GO:0031958)1.94790408
153tetrahydrofolate metabolic process (GO:0046653)1.93607551
154natural killer cell mediated cytotoxicity (GO:0042267)1.93217371
155natural killer cell mediated immunity (GO:0002228)1.93217371
156regulation of interferon-alpha production (GO:0032647)1.92953726
157definitive hemopoiesis (GO:0060216)1.92391618
158epithelial cell differentiation involved in prostate gland development (GO:0060742)1.91075788
159mRNA stabilization (GO:0048255)1.90739536
160RNA stabilization (GO:0043489)1.90739536
161cell adhesion mediated by integrin (GO:0033627)1.89729090
162positive regulation of B cell differentiation (GO:0045579)1.89522486
163B cell mediated immunity (GO:0019724)1.88563977
164mitotic metaphase plate congression (GO:0007080)1.88145813
165nuclear envelope organization (GO:0006998)1.88061718
166regulation of mitotic spindle organization (GO:0060236)1.86328804
167cellular response to growth hormone stimulus (GO:0071378)1.86272254
168dosage compensation (GO:0007549)1.86027590
169DNA strand elongation involved in DNA replication (GO:0006271)1.85628675
170establishment of chromosome localization (GO:0051303)1.85274016
171cellular response to interferon-alpha (GO:0035457)1.84867664
172regulation of protein heterodimerization activity (GO:0043497)1.84520728
173histone H2A monoubiquitination (GO:0035518)1.84401964
174regulation of attachment of spindle microtubules to kinetochore (GO:0051988)1.83966800
175attachment of spindle microtubules to kinetochore (GO:0008608)1.83046138
176positive regulation of nuclease activity (GO:0032075)1.83013587
177skin morphogenesis (GO:0043589)1.82505801
178metaphase plate congression (GO:0051310)1.81850303
179protein retention in ER lumen (GO:0006621)1.79396246
180myeloid cell homeostasis (GO:0002262)1.79364423
181monoubiquitinated protein deubiquitination (GO:0035520)1.78681596
182UDP-N-acetylglucosamine metabolic process (GO:0006047)1.78147368
183pinocytosis (GO:0006907)1.78141981
184translesion synthesis (GO:0019985)1.77384845
185regulation of nuclease activity (GO:0032069)1.76819561
186maternal placenta development (GO:0001893)1.76391022
187regulation of SMAD protein import into nucleus (GO:0060390)1.76228452
188positive regulation of SMAD protein import into nucleus (GO:0060391)1.76185911

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.31254259
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.76699051
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.58025198
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.27858142
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.20434145
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08945086
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89003591
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.84907258
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65460959
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.64449429
11ZNF274_21170338_ChIP-Seq_K562_Hela2.49644724
12EWS_26573619_Chip-Seq_HEK293_Human2.48744993
13TAF15_26573619_Chip-Seq_HEK293_Human2.31466297
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.31210103
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.30134060
16* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.29588535
17IGF1R_20145208_ChIP-Seq_DFB_Human2.28822943
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.28252273
19FUS_26573619_Chip-Seq_HEK293_Human2.26297249
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23449898
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.18359409
22AR_21909140_ChIP-Seq_LNCAP_Human2.14441447
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.08247172
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06338324
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.03468364
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.96359621
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95668563
28CLOCK_20551151_ChIP-Seq_293T_Human1.94657828
29MYC_22102868_ChIP-Seq_BL_Human1.94593472
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94061029
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92618325
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89882015
33GBX2_23144817_ChIP-Seq_PC3_Human1.88868357
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.88705582
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.88155146
36P300_19829295_ChIP-Seq_ESCs_Human1.85014473
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.84779526
38IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80062043
39* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79139146
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74887288
41* VDR_22108803_ChIP-Seq_LS180_Human1.74860279
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74015478
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71144333
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70954557
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69336798
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68346512
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67939506
48* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66754167
49* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65191486
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64726666
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61566662
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.60611673
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59630622
54* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57445226
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54472064
56* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53525800
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.53379871
58PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51582991
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50219475
60MYB_26560356_Chip-Seq_TH2_Human1.49587676
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.48334825
62ER_23166858_ChIP-Seq_MCF-7_Human1.47933896
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46908201
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46628855
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46332504
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.46076749
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.45746188
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44452075
69* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43596426
70IRF1_19129219_ChIP-ChIP_H3396_Human1.43049985
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.42666457
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42063830
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39387156
74VDR_21846776_ChIP-Seq_THP-1_Human1.38067514
75* SPI1_23547873_ChIP-Seq_NB4_Human1.37655055
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37573024
77FOXP3_21729870_ChIP-Seq_TREG_Human1.36909257
78ELK1_19687146_ChIP-ChIP_HELA_Human1.36104478
79* MAF_26560356_Chip-Seq_TH1_Human1.35779981
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33693287
81PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32915939
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32544294
83STAT4_19710469_ChIP-ChIP_TH1__Mouse1.29872342
84MYB_26560356_Chip-Seq_TH1_Human1.29831604
85* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29374475
86* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28522253
87MYC_18940864_ChIP-ChIP_HL60_Human1.27670863
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.27427994
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27221537
90PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27159812
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26806988
92TFEB_21752829_ChIP-Seq_HELA_Human1.26515764
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26327811
94SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25776614
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25776614
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24989279
97KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24651360
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23312659
99CBP_20019798_ChIP-Seq_JUKART_Human1.23312659
100* IRF8_27001747_Chip-Seq_BMDM_Mouse1.23205783
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.22740581
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.22226844
103* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21391579
104* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21302419
105GATA1_22025678_ChIP-Seq_K562_Human1.21220658
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.21006189
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20812732
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20293345
109SMAD4_21799915_ChIP-Seq_A2780_Human1.20078098
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19561452
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19528597
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.19348745
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18687761
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17411035
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16935305
116HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16764978
117XRN2_22483619_ChIP-Seq_HELA_Human1.16537841
118* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15504962
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15035997
120JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14845918
121UTX_26944678_Chip-Seq_JUKART_Human1.14827440
122SCL_19346495_ChIP-Seq_HPC-7_Human1.14524407
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14437334
124RXR_22158963_ChIP-Seq_LIVER_Mouse1.13949168
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.13609621
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13461993
127CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12441031
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12048653
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12019961
130TCF7_22412390_ChIP-Seq_EML_Mouse1.11877250
131ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11079925
132CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10709878
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09959981
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.09211316
135* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08854353
136RUNX1_22412390_ChIP-Seq_EML_Mouse1.08737533
137RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07440384
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.07357973
139STAT3_23295773_ChIP-Seq_U87_Human1.06548632
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06293313
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05665244
142BRD4_25478319_ChIP-Seq_HGPS_Human1.05468911
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05446254
144* CDX2_22108803_ChIP-Seq_LS180_Human1.04271717
145VDR_24763502_ChIP-Seq_THP-1_Human1.04168707
146* GABP_17652178_ChIP-ChIP_JURKAT_Human1.04024467
147SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03686461
148KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03544159
149VDR_23849224_ChIP-Seq_CD4+_Human1.02092244
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.01236231
151EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01194220
152FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00934266
153E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00628063
154SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00060820
155TRIM28_21343339_ChIP-Seq_HEK293_Human0.99185450
156* SRF_21415370_ChIP-Seq_HL-1_Mouse0.98669737
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98588770
158NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98588770
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.98310507
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98240390
161MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97648582
162MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97577691
163ATF3_27146783_Chip-Seq_COLON_Human0.97257543
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97251963
165P53_22387025_ChIP-Seq_ESCs_Mouse0.97211902
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97088633
167* CHD1_26751641_Chip-Seq_LNCaP_Human0.97035243
168MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96868106
169STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96824558
170PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96801950
171TP63_19390658_ChIP-ChIP_HaCaT_Human0.96624707
172SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96062832
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95869166
174HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95526053
175KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95412707
176DCP1A_22483619_ChIP-Seq_HELA_Human0.95337166
177CMYC_18555785_Chip-Seq_ESCs_Mouse0.94455665
178* TCF4_22108803_ChIP-Seq_LS180_Human0.94386205
179TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93984361
180FOXO3_23340844_ChIP-Seq_DLD1_Human0.93875144
181HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93353370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.62322202
2MP0000569_abnormal_digit_pigmentation3.33079534
3MP0010352_gastrointestinal_tract_polyps3.09232260
4MP0002102_abnormal_ear_morphology3.08620655
5MP0009697_abnormal_copulation2.81133993
6MP0003705_abnormal_hypodermis_morpholog2.68028841
7MP0010234_abnormal_vibrissa_follicle2.66255774
8MP0008877_abnormal_DNA_methylation2.53183088
9MP0006054_spinal_hemorrhage2.47756580
10MP0000427_abnormal_hair_cycle2.25055903
11MP0003195_calcinosis2.24452744
12MP0003221_abnormal_cardiomyocyte_apopto2.16952334
13MP0008932_abnormal_embryonic_tissue2.07485642
14MP0008438_abnormal_cutaneous_collagen2.05634737
15MP0003718_maternal_effect1.98386125
16MP0000647_abnormal_sebaceous_gland1.97128471
17MP0003786_premature_aging1.92873492
18MP0006072_abnormal_retinal_apoptosis1.90768466
19MP0005253_abnormal_eye_physiology1.86487444
20MP0003693_abnormal_embryo_hatching1.81502415
21MP0003890_abnormal_embryonic-extraembry1.81302855
22MP0005275_abnormal_skin_tensile1.80063027
23MP0003436_decreased_susceptibility_to1.79149560
24MP0005076_abnormal_cell_differentiation1.73733875
25MP0003950_abnormal_plasma_membrane1.71779621
26MP0005084_abnormal_gallbladder_morpholo1.70491718
27MP0003300_gastrointestinal_ulcer1.69812921
28MP0002166_altered_tumor_susceptibility1.65294701
29MP0001835_abnormal_antigen_presentation1.65129878
30MP0003937_abnormal_limbs/digits/tail_de1.63505630
31MP0010307_abnormal_tumor_latency1.63362053
32MP0003566_abnormal_cell_adhesion1.60810656
33MP0001529_abnormal_vocalization1.60541442
34MP0004947_skin_inflammation1.58091665
35MP0008789_abnormal_olfactory_epithelium1.55694258
36MP0004957_abnormal_blastocyst_morpholog1.48376686
37MP0002751_abnormal_autonomic_nervous1.47488202
38MP0001293_anophthalmia1.47073488
39MP0005023_abnormal_wound_healing1.47043134
40MP0000685_abnormal_immune_system1.45400008
41MP0005187_abnormal_penis_morphology1.44941108
42MP0002006_tumorigenesis1.44031045
43MP0004808_abnormal_hematopoietic_stem1.41472325
44MP0002060_abnormal_skin_morphology1.40081818
45MP0008007_abnormal_cellular_replicative1.40051820
46MP0000383_abnormal_hair_follicle1.39086208
47MP0009053_abnormal_anal_canal1.33753963
48MP0003077_abnormal_cell_cycle1.32702014
49MP0009785_altered_susceptibility_to1.31836490
50MP0002877_abnormal_melanocyte_morpholog1.31582597
51MP0002938_white_spotting1.31346618
52MP0002396_abnormal_hematopoietic_system1.29648202
53MP0002736_abnormal_nociception_after1.27996465
54MP0000465_gastrointestinal_hemorrhage1.24776809
55MP0008057_abnormal_DNA_replication1.24025437
56MP0001545_abnormal_hematopoietic_system1.22775613
57MP0005397_hematopoietic_system_phenotyp1.22775613
58MP0003453_abnormal_keratinocyte_physiol1.22569019
59MP0003567_abnormal_fetal_cardiomyocyte1.19382866
60MP0002233_abnormal_nose_morphology1.19366739
61MP0000372_irregular_coat_pigmentation1.19166204
62MP0009278_abnormal_bone_marrow1.17995756
63MP0005171_absent_coat_pigmentation1.17839602
64MP0003121_genomic_imprinting1.17510822
65MP0010094_abnormal_chromosome_stability1.16415871
66MP0002095_abnormal_skin_pigmentation1.15611579
67MP0002796_impaired_skin_barrier1.15274274
68MP0009333_abnormal_splenocyte_physiolog1.14893574
69MP0000858_altered_metastatic_potential1.14396780
70MP0003303_peritoneal_inflammation1.14165044
71MP0000490_abnormal_crypts_of1.12384798
72MP0002452_abnormal_antigen_presenting1.11794129
73MP0010155_abnormal_intestine_physiology1.11372650
74MP0003763_abnormal_thymus_physiology1.10298439
75MP0005025_abnormal_response_to1.09500470
76MP0005000_abnormal_immune_tolerance1.09193158
77MP0001800_abnormal_humoral_immune1.08667388
78MP0005391_vision/eye_phenotype1.08438699
79MP0001243_abnormal_dermal_layer1.08216742
80MP0002419_abnormal_innate_immunity1.07159502
81MP0003755_abnormal_palate_morphology1.07085033
82MP0005499_abnormal_olfactory_system1.07008801
83MP0005394_taste/olfaction_phenotype1.07008801
84MP0001216_abnormal_epidermal_layer1.06616737
85MP0005174_abnormal_tail_pigmentation1.06567439
86MP0000358_abnormal_cell_content/1.05108039
87MP0001533_abnormal_skeleton_physiology1.04731330
88MP0002084_abnormal_developmental_patter1.04463301
89MP0001853_heart_inflammation1.04019869
90MP0001119_abnormal_female_reproductive1.02849610
91MP0010678_abnormal_skin_adnexa1.02259636
92MP0003279_aneurysm1.01709012
93MP0001730_embryonic_growth_arrest1.00995832
94MP0003941_abnormal_skin_development1.00854120
95MP0001286_abnormal_eye_development1.00271528
96MP0005395_other_phenotype0.99998737
97MP0005360_urolithiasis0.99946667
98MP0001697_abnormal_embryo_size0.99920736
99MP0001986_abnormal_taste_sensitivity0.99428787
100MP0002148_abnormal_hypersensitivity_rea0.98838971
101* MP0001819_abnormal_immune_cell0.98626412
102MP0002398_abnormal_bone_marrow0.98456557
103MP0002139_abnormal_hepatobiliary_system0.98450569
104MP0002405_respiratory_system_inflammati0.98321170
105MP0005464_abnormal_platelet_physiology0.98281415
106* MP0002420_abnormal_adaptive_immunity0.98263759
107MP0005501_abnormal_skin_physiology0.98079427
108MP0003724_increased_susceptibility_to0.97999406
109MP0004264_abnormal_extraembryonic_tissu0.97967695
110MP0003448_altered_tumor_morphology0.97648662
111MP0000350_abnormal_cell_proliferation0.97240842
112MP0004197_abnormal_fetal_growth/weight/0.96866739
113MP0002723_abnormal_immune_serum0.95912452
114MP0005671_abnormal_response_to0.95658715
115MP0009840_abnormal_foam_cell0.95407972
116MP0000537_abnormal_urethra_morphology0.95214930
117MP0002138_abnormal_hepatobiliary_system0.95170537
118MP0003136_yellow_coat_color0.94913776
119MP0001324_abnormal_eye_pigmentation0.93753557
120MP0002933_joint_inflammation0.92852859
121MP0000015_abnormal_ear_pigmentation0.92395055
122MP0002086_abnormal_extraembryonic_tissu0.90841344
123MP0006035_abnormal_mitochondrial_morpho0.90667468
124MP0002090_abnormal_vision0.90654481
125MP0005380_embryogenesis_phenotype0.90485956
126MP0001672_abnormal_embryogenesis/_devel0.90485956
127MP0003111_abnormal_nucleus_morphology0.90386944
128MP0001845_abnormal_inflammatory_respons0.89819184
129MP0001764_abnormal_homeostasis0.89783528
130MP0000377_abnormal_hair_follicle0.89647031
131MP0005387_immune_system_phenotype0.88745694
132MP0001790_abnormal_immune_system0.88745694
133MP0005551_abnormal_eye_electrophysiolog0.88514473
134MP0002722_abnormal_immune_system0.87957153
135MP0004272_abnormal_basement_membrane0.87674586
136MP0003880_abnormal_central_pattern0.87472732
137MP0001915_intracranial_hemorrhage0.86528696
138MP0001984_abnormal_olfaction0.86403441
139MP0001177_atelectasis0.86034952
140MP0000716_abnormal_immune_system0.85174989
141MP0002019_abnormal_tumor_incidence0.84549782
142MP0010368_abnormal_lymphatic_system0.84061079
143MP0002098_abnormal_vibrissa_morphology0.84052821
144MP0003191_abnormal_cellular_cholesterol0.83369862
145MP0001929_abnormal_gametogenesis0.83238336
146MP0002234_abnormal_pharynx_morphology0.82747306
147MP0005365_abnormal_bile_salt0.82542835
148MP0005075_abnormal_melanosome_morpholog0.82518980
149MP0009384_cardiac_valve_regurgitation0.82200784
150MP0005248_abnormal_Harderian_gland0.81806237
151MP0002429_abnormal_blood_cell0.81375465
152MP0000689_abnormal_spleen_morphology0.81217413
153MP0002177_abnormal_outer_ear0.80456872
154MP0001188_hyperpigmentation0.80116277
155MP0005220_abnormal_exocrine_pancreas0.79281129
156MP0002088_abnormal_embryonic_growth/wei0.79224255
157MP0005367_renal/urinary_system_phenotyp0.78434430
158MP0000516_abnormal_urinary_system0.78434430
159MP0003252_abnormal_bile_duct0.78206040
160MP0003806_abnormal_nucleotide_metabolis0.78186629
161MP0001191_abnormal_skin_condition0.77947160
162MP0003186_abnormal_redox_activity0.77295437
163MP0003011_delayed_dark_adaptation0.76931697
164MP0002697_abnormal_eye_size0.76890160
165MP0002009_preneoplasia0.76514037
166MP0003123_paternal_imprinting0.76409727
167MP0003984_embryonic_growth_retardation0.76235197
168MP0002638_abnormal_pupillary_reflex0.75745802
169MP0002085_abnormal_embryonic_tissue0.74910040
170MP0003787_abnormal_imprinting0.73529478
171MP0000653_abnormal_sex_gland0.70950731
172MP0002282_abnormal_trachea_morphology0.70023428
173MP0003935_abnormal_craniofacial_develop0.69765923
174MP0002928_abnormal_bile_duct0.66765061
175MP0003943_abnormal_hepatobiliary_system0.63608242
176MP0003119_abnormal_digestive_system0.63473164
177MP0002111_abnormal_tail_morphology0.63116011
178MP0005195_abnormal_posterior_eye0.62268706
179MP0002210_abnormal_sex_determination0.61631193
180MP0009703_decreased_birth_body0.60327928

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of chromosome stability (HP:0003220)3.26854901
2Pancreatic cysts (HP:0001737)3.14319549
3Eczematoid dermatitis (HP:0000976)3.04924059
4Aplasia/Hypoplasia of the tibia (HP:0005772)3.03804032
5Meckel diverticulum (HP:0002245)2.97548600
6Abnormality of the ileum (HP:0001549)2.96426509
7Aplasia/Hypoplasia of the uvula (HP:0010293)2.94240119
8Hematochezia (HP:0002573)2.93899814
9Medial flaring of the eyebrow (HP:0010747)2.93849436
10Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73919958
11Congenital primary aphakia (HP:0007707)2.69120123
12Abnormality of midbrain morphology (HP:0002418)2.67501398
13Molar tooth sign on MRI (HP:0002419)2.67501398
14Pancreatic fibrosis (HP:0100732)2.67248947
15True hermaphroditism (HP:0010459)2.65148608
16Protrusio acetabuli (HP:0003179)2.61966445
17Chromsome breakage (HP:0040012)2.60631250
18Short tibia (HP:0005736)2.55713146
19Volvulus (HP:0002580)2.53695111
20Peritonitis (HP:0002586)2.53662159
21Thrombocytosis (HP:0001894)2.53355431
22Nephrogenic diabetes insipidus (HP:0009806)2.52720765
23Gait imbalance (HP:0002141)2.50709368
24Bifid tongue (HP:0010297)2.48761855
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.48702518
26Progressive inability to walk (HP:0002505)2.48097659
27Spontaneous hematomas (HP:0007420)2.44442201
28Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.44058086
29Short 4th metacarpal (HP:0010044)2.44058086
30Duodenal stenosis (HP:0100867)2.42536199
31Small intestinal stenosis (HP:0012848)2.42536199
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.42300970
33Abnormality of alanine metabolism (HP:0010916)2.42300970
34Hyperalaninemia (HP:0003348)2.42300970
35Subacute progressive viral hepatitis (HP:0006572)2.41775360
36Asymmetry of the thorax (HP:0001555)2.41228759
37Intestinal atresia (HP:0011100)2.39839240
38Abnormality of the preputium (HP:0100587)2.39167453
39Lissencephaly (HP:0001339)2.36434521
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.34060644
41Osteolytic defects of the hand bones (HP:0009699)2.34060644
42Sloping forehead (HP:0000340)2.33301296
43Genital tract atresia (HP:0001827)2.32758775
44Abnormal lung lobation (HP:0002101)2.31980751
45Methylmalonic acidemia (HP:0002912)2.27695937
46Birth length less than 3rd percentile (HP:0003561)2.25278069
47Abnormality of the duodenum (HP:0002246)2.20471301
48Medulloblastoma (HP:0002885)2.19822028
49Clubbing of toes (HP:0100760)2.18408448
50Vaginal atresia (HP:0000148)2.18070006
51Papillary thyroid carcinoma (HP:0002895)2.15933846
52Embryonal renal neoplasm (HP:0011794)2.15332114
53Glioma (HP:0009733)2.15293033
54Thyroid carcinoma (HP:0002890)2.11550901
55Cerebellar dysplasia (HP:0007033)2.11185031
56Cutaneous melanoma (HP:0012056)2.10913845
57Small hand (HP:0200055)2.10302421
58Increased mean platelet volume (HP:0011877)2.09398341
59Abnormal platelet volume (HP:0011876)2.05716837
60Recurrent gram-negative bacterial infections (HP:0005420)2.05600327
61Cervical subluxation (HP:0003308)2.04596538
62Nephroblastoma (Wilms tumor) (HP:0002667)2.04588313
63Retinal dysplasia (HP:0007973)2.04303659
64Erythroderma (HP:0001019)2.02989934
65Periodontitis (HP:0000704)2.02618006
66Recurrent viral infections (HP:0004429)2.01541121
67Broad foot (HP:0001769)2.00267770
68Abnormal protein glycosylation (HP:0012346)2.00051436
69Abnormal glycosylation (HP:0012345)2.00051436
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00051436
71Abnormal protein N-linked glycosylation (HP:0012347)2.00051436
72Aortic dissection (HP:0002647)1.99672619
73Chorioretinal atrophy (HP:0000533)1.99607681
74Abnormality of methionine metabolism (HP:0010901)1.99603665
75Aortic aneurysm (HP:0004942)1.99270687
76Rhabdomyosarcoma (HP:0002859)1.99263360
77Syringomyelia (HP:0003396)1.98978563
78Spinal cord lesions (HP:0100561)1.98978563
79Dandy-Walker malformation (HP:0001305)1.98884214
80Astigmatism (HP:0000483)1.98449930
81Esophageal varix (HP:0002040)1.98237441
82Rectal prolapse (HP:0002035)1.95840735
83Abnormality of the calcaneus (HP:0008364)1.94918612
84Abnormal auditory evoked potentials (HP:0006958)1.94877836
85Elevated erythrocyte sedimentation rate (HP:0003565)1.94317172
86Increased density of long bones (HP:0006392)1.93518115
87Arterial thrombosis (HP:0004420)1.93439701
88Recurrent bacterial skin infections (HP:0005406)1.93331622
89Thyroiditis (HP:0100646)1.93049602
90Amyotrophic lateral sclerosis (HP:0007354)1.92507377
91Preaxial hand polydactyly (HP:0001177)1.90101591
92Abnormality of the 4th metacarpal (HP:0010012)1.89845505
93Abnormality of the peritoneum (HP:0002585)1.89429137
94Abnormality of serum amino acid levels (HP:0003112)1.87955523
95Spastic diplegia (HP:0001264)1.87342207
96Median cleft lip (HP:0000161)1.87226372
97Renal cortical cysts (HP:0000803)1.86914383
98Colon cancer (HP:0003003)1.86253142
99Micronodular cirrhosis (HP:0001413)1.85835892
100Interstitial pulmonary disease (HP:0006530)1.85499470
101Premature rupture of membranes (HP:0001788)1.85400053
102Autoimmune thrombocytopenia (HP:0001973)1.84995153
103Astrocytoma (HP:0009592)1.84450243
104Abnormality of the astrocytes (HP:0100707)1.84450243
105Pendular nystagmus (HP:0012043)1.84244521
106Exostoses (HP:0100777)1.84003361
107Poikiloderma (HP:0001029)1.83906785
108T lymphocytopenia (HP:0005403)1.83090278
109Abnormality of T cell number (HP:0011839)1.82907066
110Ependymoma (HP:0002888)1.82427419
111Myocardial infarction (HP:0001658)1.82380367
112Hypoplastic pelvis (HP:0008839)1.82236931
113Inability to walk (HP:0002540)1.82214787
114Recurrent abscess formation (HP:0002722)1.81983821
115Cortical dysplasia (HP:0002539)1.81164757
116Deviation of the thumb (HP:0009603)1.81041239
117Ankle contracture (HP:0006466)1.80706971
118Abnormality of the labia minora (HP:0012880)1.79165138
119Deep venous thrombosis (HP:0002625)1.79150905
120Soft skin (HP:0000977)1.78500487
121Poor coordination (HP:0002370)1.78112217
122Curly hair (HP:0002212)1.77603760
123Cerebral aneurysm (HP:0004944)1.77075371
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76955711
125Abnormality of the common coagulation pathway (HP:0010990)1.76809769
126Postaxial hand polydactyly (HP:0001162)1.76527980
127Absent speech (HP:0001344)1.76207008
128Nephronophthisis (HP:0000090)1.75950586
129Methylmalonic aciduria (HP:0012120)1.75479704
130Abnormality of the carotid arteries (HP:0005344)1.75456199
131Abnormal foot bone ossification (HP:0010675)1.74868830
132Thoracolumbar scoliosis (HP:0002944)1.74469638
133Type II lissencephaly (HP:0007260)1.74360312
134Ectropion (HP:0000656)1.73610027
135Abnormality of the musculature of the pelvis (HP:0001469)1.73143113
136Abnormality of the hip-girdle musculature (HP:0001445)1.73143113
137Postaxial foot polydactyly (HP:0001830)1.72105654
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.71611458
139Dilatation of the ascending aorta (HP:0005111)1.71562112
140Type I transferrin isoform profile (HP:0003642)1.71522056
141Absent radius (HP:0003974)1.71150755
142Abnormality of the renal cortex (HP:0011035)1.71033705
143Gastrointestinal infarctions (HP:0005244)1.70820377
144Myositis (HP:0100614)1.70420549
145Entropion (HP:0000621)1.70304603
146Hypothermia (HP:0002045)1.69855431
147Microglossia (HP:0000171)1.68399231
148Neoplasm of the adrenal cortex (HP:0100641)1.68340777
149Myelodysplasia (HP:0002863)1.67971310
150Arterial tortuosity (HP:0005116)1.67943552
151Ectopic kidney (HP:0000086)1.67780849
152Nonimmune hydrops fetalis (HP:0001790)1.67365333
153Recurrent fungal infections (HP:0002841)1.66353255
154Supernumerary spleens (HP:0009799)1.66305617
155Shallow orbits (HP:0000586)1.66262986
156Disproportionate short-trunk short stature (HP:0003521)1.65305637
157Vertebral compression fractures (HP:0002953)1.65250783
158Selective tooth agenesis (HP:0001592)1.65180903
159Degeneration of anterior horn cells (HP:0002398)1.63671609
160Abnormality of the anterior horn cell (HP:0006802)1.63671609
161Hypobetalipoproteinemia (HP:0003563)1.62228648
162Cellulitis (HP:0100658)1.61994771
16311 pairs of ribs (HP:0000878)1.61647210
164Chronic otitis media (HP:0000389)1.60814101
165Thin bony cortex (HP:0002753)1.59963753
166Mitral valve prolapse (HP:0001634)1.59708846
167Proximal placement of thumb (HP:0009623)1.59658509
168Acute myeloid leukemia (HP:0004808)1.59616477
169Vascular tortuosity (HP:0004948)1.57747398
170Abnormality of monocarboxylic acid metabolism (HP:0010996)1.57537790
171Increased IgE level (HP:0003212)1.57335315
172Gangrene (HP:0100758)1.54751624
173Osteomyelitis (HP:0002754)1.54122169
174Amaurosis fugax (HP:0100576)1.53283391
175Ulnar bowing (HP:0003031)1.53120088
176Gingival bleeding (HP:0000225)1.52932321
177Bicuspid aortic valve (HP:0001647)1.52062483
178Viral hepatitis (HP:0006562)1.51691845
179Enlarged penis (HP:0000040)1.51560526
180Thrombophlebitis (HP:0004418)1.50789257
181Hepatocellular carcinoma (HP:0001402)1.49986856
182Orchitis (HP:0100796)1.49745631
183Back pain (HP:0003418)1.49473377
184Wormian bones (HP:0002645)1.49174202
185Abnormality of T cells (HP:0002843)1.48401341
186High pitched voice (HP:0001620)1.48102885
187Biliary tract neoplasm (HP:0100574)1.48047971
188Persistence of primary teeth (HP:0006335)1.47878773
189Metaphyseal cupping (HP:0003021)1.46601604
190Skin ulcer (HP:0200042)1.45128552
191Petechiae (HP:0000967)1.44944115
192Ureteral obstruction (HP:0006000)1.44653215
193Radial bowing (HP:0002986)1.44331247
194Gastrointestinal carcinoma (HP:0002672)1.43389574
195Malignant gastrointestinal tract tumors (HP:0006749)1.43389574
196Hallux valgus (HP:0001822)1.41696927
197Aneurysm (HP:0002617)1.41243741

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.22894793
2BCR3.57388015
3SRPK12.80635005
4FRK2.43304378
5BMPR1B2.28534686
6STK102.27695154
7PKN22.24728145
8WNK32.24391440
9TRIB32.22895548
10MAP4K22.18653268
11EEF2K1.99119851
12MKNK21.97414946
13LRRK21.92727237
14ERN11.89236879
15LATS11.87618172
16NEK11.82224618
17TGFBR11.81985508
18PTK61.79969495
19RPS6KA41.79660638
20PASK1.77867524
21ACVR1B1.70795068
22JAK31.69967865
23NEK21.66914156
24MAP3K101.59273702
25MAP3K41.59157072
26ZAK1.56470336
27RPS6KB21.54490228
28BRD41.52555766
29FGFR41.50149350
30CDC71.49921491
31CSNK1A1L1.49753954
32FLT31.49557214
33MAP3K141.48922493
34CSNK1G11.47053538
35TYK21.45336793
36PLK21.44977982
37CSNK1G31.44600806
38SIK31.44564582
39STK38L1.40912734
40NEK91.40600990
41TBK11.40353318
42CSNK1G21.40091052
43TESK11.39695993
44MAP4K11.39245251
45PLK41.39000182
46CDK61.36140909
47EPHA31.34348121
48STK31.33350389
49MST41.32305421
50TTK1.32304158
51FGFR31.31813019
52BRSK21.29348641
53WEE11.29092230
54MAP2K71.26860861
55TNIK1.26457951
56SCYL21.24451005
57ZAP701.22060888
58MAP3K81.18867419
59PAK41.18478749
60PBK1.14465064
61TRPM71.12220862
62BTK1.11969025
63STK41.11727871
64PIM21.10613057
65CCNB11.09396414
66FGFR21.05998445
67PIM11.05853693
68INSRR1.04887169
69MST1R1.04691196
70ADRBK21.03779842
71BLK1.03588440
72CHUK1.03132999
73ITK1.02257873
74PDGFRA1.01576670
75EIF2AK11.00867279
76ERBB41.00138624
77KDR0.98918360
78EPHA20.98818286
79NME20.98265111
80TAF10.97862728
81TTN0.95757398
82CASK0.95331876
83ERBB30.94760014
84MAP3K30.94299361
85PDK20.93002754
86TEC0.91873053
87GRK10.91165332
88NUAK10.90840579
89FER0.89352009
90TGFBR20.89188386
91RIPK10.87575306
92PNCK0.86944909
93CDK120.86352745
94SIK10.86307397
95AURKB0.85621640
96IRAK40.84802723
97MAP3K120.84015884
98CDK40.83643381
99EPHB10.83456500
100TESK20.83093824
101FGFR10.82218765
102MAP2K30.81284982
103MAPKAPK30.80764540
104KSR10.80463890
105MAPK130.80413480
106EIF2AK20.80341602
107IKBKB0.79527019
108MET0.78133682
109CSK0.76107803
110IKBKE0.74464837
111CDK70.73845946
112AKT30.71979028
113PAK30.71901628
114OXSR10.71702757
115KIT0.71173995
116STK160.70907878
117BUB10.70359067
118MKNK10.70105376
119PRKCE0.69273382
120ATR0.69266962
121DYRK1B0.67722415
122PTK20.67123398
123YES10.65794340
124EIF2AK30.65595492
125DYRK30.64401844
126PDGFRB0.63603917
127CSF1R0.62134820
128PLK30.62021859
129JAK10.61991267
130MELK0.61083348
131TAOK30.60963124
132TXK0.59466244
133BMPR20.59337140
134NLK0.58523206
135MAPKAPK20.58018064
136PAK20.57873705
137VRK10.56865695
138CAMKK20.56695803
139ATM0.56376138
140JAK20.55138548
141GRK60.54695829
142MTOR0.53582464
143BMX0.52598835
144PLK10.51898502
145LCK0.51348613
146TSSK60.50403288
147ADRBK10.49716330
148DYRK20.49422886
149TIE10.40699823
150CHEK20.39455383
151STK390.38716874
152MINK10.34976502
153IRAK10.33151171
154EGFR0.33128800
155BCKDK0.31184560
156CSNK1D0.27493104
157MUSK0.27222878
158LIMK10.26016087
159CHEK10.25862167
160RPS6KA50.25302954
161NEK60.25229986
162CSNK2A10.24158702
163MAP3K50.23462399
164CLK10.22422467
165RAF10.20612739
166IGF1R0.19536382

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.96202362
2Homologous recombination_Homo sapiens_hsa034402.86615964
3Basal transcription factors_Homo sapiens_hsa030222.64879828
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.64780275
5Steroid biosynthesis_Homo sapiens_hsa001002.24392688
6Propanoate metabolism_Homo sapiens_hsa006402.23103961
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.13568860
8RNA polymerase_Homo sapiens_hsa030202.06652295
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.96215319
10DNA replication_Homo sapiens_hsa030301.89387991
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81993333
12Legionellosis_Homo sapiens_hsa051341.79512916
13Leishmaniasis_Homo sapiens_hsa051401.71428015
14One carbon pool by folate_Homo sapiens_hsa006701.68571640
15Antigen processing and presentation_Homo sapiens_hsa046121.65182052
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64572483
17Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.61341674
18Selenocompound metabolism_Homo sapiens_hsa004501.53807458
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53803338
20Cell cycle_Homo sapiens_hsa041101.53689905
21p53 signaling pathway_Homo sapiens_hsa041151.47111888
22Small cell lung cancer_Homo sapiens_hsa052221.46686794
23Fatty acid elongation_Homo sapiens_hsa000621.45746456
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.45529862
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37567955
26Staphylococcus aureus infection_Homo sapiens_hsa051501.33809958
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32962269
28Measles_Homo sapiens_hsa051621.32930830
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31878384
30Mismatch repair_Homo sapiens_hsa034301.31202315
31Herpes simplex infection_Homo sapiens_hsa051681.29755178
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28879600
33Chronic myeloid leukemia_Homo sapiens_hsa052201.25900684
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23734877
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20351526
36Base excision repair_Homo sapiens_hsa034101.18929101
37Viral myocarditis_Homo sapiens_hsa054161.18889905
38Viral carcinogenesis_Homo sapiens_hsa052031.18536086
39* Toxoplasmosis_Homo sapiens_hsa051451.16296867
40Butanoate metabolism_Homo sapiens_hsa006501.13332392
41RNA transport_Homo sapiens_hsa030131.12521716
42Shigellosis_Homo sapiens_hsa051311.12492090
43Nitrogen metabolism_Homo sapiens_hsa009101.11710694
44Spliceosome_Homo sapiens_hsa030401.11117354
45MicroRNAs in cancer_Homo sapiens_hsa052061.10620829
46Apoptosis_Homo sapiens_hsa042101.10098965
47Adherens junction_Homo sapiens_hsa045201.07605309
48* Leukocyte transendothelial migration_Homo sapiens_hsa046701.07492601
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06219485
50Oocyte meiosis_Homo sapiens_hsa041141.05114345
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.04473526
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03971659
53Pancreatic cancer_Homo sapiens_hsa052121.00917932
54Hepatitis B_Homo sapiens_hsa051611.00635859
55Malaria_Homo sapiens_hsa051440.99981625
56TNF signaling pathway_Homo sapiens_hsa046680.99444673
57Systemic lupus erythematosus_Homo sapiens_hsa053220.99229058
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98958456
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98641612
60Complement and coagulation cascades_Homo sapiens_hsa046100.98572887
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96603928
62Influenza A_Homo sapiens_hsa051640.96286518
63Osteoclast differentiation_Homo sapiens_hsa043800.96220464
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94378923
65Phototransduction_Homo sapiens_hsa047440.93087226
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.92074008
67Caffeine metabolism_Homo sapiens_hsa002320.91225319
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.90730838
69HTLV-I infection_Homo sapiens_hsa051660.90558306
70Proteoglycans in cancer_Homo sapiens_hsa052050.88976160
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88612574
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.88177204
73Purine metabolism_Homo sapiens_hsa002300.86665762
74Thyroid cancer_Homo sapiens_hsa052160.86253512
75Hematopoietic cell lineage_Homo sapiens_hsa046400.85728539
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84911203
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83747110
78Graft-versus-host disease_Homo sapiens_hsa053320.83606033
79* Pertussis_Homo sapiens_hsa051330.83391858
80TGF-beta signaling pathway_Homo sapiens_hsa043500.83154643
81mRNA surveillance pathway_Homo sapiens_hsa030150.83153092
82Primary immunodeficiency_Homo sapiens_hsa053400.82691602
83Epstein-Barr virus infection_Homo sapiens_hsa051690.82061762
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.81578202
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.81531745
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80968645
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80398986
88Nucleotide excision repair_Homo sapiens_hsa034200.80070801
89Circadian rhythm_Homo sapiens_hsa047100.80054750
90Non-homologous end-joining_Homo sapiens_hsa034500.78695435
91Allograft rejection_Homo sapiens_hsa053300.78510974
92Renin-angiotensin system_Homo sapiens_hsa046140.77921230
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77522376
94ECM-receptor interaction_Homo sapiens_hsa045120.76776174
95Regulation of autophagy_Homo sapiens_hsa041400.76569503
96Focal adhesion_Homo sapiens_hsa045100.75402210
97Ribosome_Homo sapiens_hsa030100.74066884
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72506259
99B cell receptor signaling pathway_Homo sapiens_hsa046620.70964891
100Acute myeloid leukemia_Homo sapiens_hsa052210.70717252
101Folate biosynthesis_Homo sapiens_hsa007900.69103302
102Hepatitis C_Homo sapiens_hsa051600.68787301
103Prostate cancer_Homo sapiens_hsa052150.68622777
104Pentose phosphate pathway_Homo sapiens_hsa000300.68172853
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68155579
106Ether lipid metabolism_Homo sapiens_hsa005650.65316768
107Amoebiasis_Homo sapiens_hsa051460.65100111
108T cell receptor signaling pathway_Homo sapiens_hsa046600.64960386
109Bladder cancer_Homo sapiens_hsa052190.64609031
110Tuberculosis_Homo sapiens_hsa051520.64107229
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63913903
112Peroxisome_Homo sapiens_hsa041460.63181089
113Protein export_Homo sapiens_hsa030600.62927984
114Proteasome_Homo sapiens_hsa030500.61346858
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61080146
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60946770
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60742111
118Colorectal cancer_Homo sapiens_hsa052100.60606582
119Salmonella infection_Homo sapiens_hsa051320.60352022
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58093306
121Hippo signaling pathway_Homo sapiens_hsa043900.58068678
122N-Glycan biosynthesis_Homo sapiens_hsa005100.57978316
123Sulfur metabolism_Homo sapiens_hsa009200.57908002
124Fat digestion and absorption_Homo sapiens_hsa049750.57381087
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56077698
126* Platelet activation_Homo sapiens_hsa046110.54185436
127* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54117237
128Tryptophan metabolism_Homo sapiens_hsa003800.53635045
129Pyruvate metabolism_Homo sapiens_hsa006200.53494798
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.53136961
131Insulin resistance_Homo sapiens_hsa049310.53073650
132RNA degradation_Homo sapiens_hsa030180.52190231
133Hedgehog signaling pathway_Homo sapiens_hsa043400.50110839
134Glutathione metabolism_Homo sapiens_hsa004800.49601259
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49509725
136Pyrimidine metabolism_Homo sapiens_hsa002400.48977093
137Sphingolipid metabolism_Homo sapiens_hsa006000.45784332
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45522407
139Metabolic pathways_Homo sapiens_hsa011000.45129025
140* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41681186
141Collecting duct acid secretion_Homo sapiens_hsa049660.40733059
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38912373
143Linoleic acid metabolism_Homo sapiens_hsa005910.34139175
144Biosynthesis of amino acids_Homo sapiens_hsa012300.31736657
145Fatty acid metabolism_Homo sapiens_hsa012120.31341647
146Oxidative phosphorylation_Homo sapiens_hsa001900.30536265
147Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29910778
148Huntingtons disease_Homo sapiens_hsa050160.29777081
149beta-Alanine metabolism_Homo sapiens_hsa004100.28658019
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27894186
151Lysine degradation_Homo sapiens_hsa003100.27395273
152Steroid hormone biosynthesis_Homo sapiens_hsa001400.25544031
153Vitamin B6 metabolism_Homo sapiens_hsa007500.25359958
154Parkinsons disease_Homo sapiens_hsa050120.23583810
155Phagosome_Homo sapiens_hsa041450.22189353
156SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21301721
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21103407
158Taste transduction_Homo sapiens_hsa047420.20548228

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