GMPPB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is thought to encode a GDP-mannose pyrophosphorylase. The encoded protein catalyzes the conversion of mannose-1-phosphate and GTP to GDP-mannose, a reaction involved in the production of N-linked oligosaccharides. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.98805320
2Golgi transport vesicle coating (GO:0048200)7.98805320
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.01314005
4protein retention in ER lumen (GO:0006621)6.50136239
5cellular response to ATP (GO:0071318)6.12863549
6signal peptide processing (GO:0006465)6.07379590
7COPII vesicle coating (GO:0048208)4.94309396
8protein maturation by protein folding (GO:0022417)4.81382468
9exocrine pancreas development (GO:0031017)4.73273131
10intestinal cholesterol absorption (GO:0030299)4.64516322
11negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.44187601
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.35336382
13positive regulation of nuclease activity (GO:0032075)4.22906095
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22045636
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.20821195
16protein targeting to ER (GO:0045047)4.14371766
17cotranslational protein targeting to membrane (GO:0006613)4.09716907
18positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.01693006
19UV protection (GO:0009650)4.00908746
20regulation of nuclease activity (GO:0032069)3.97881793
21endoplasmic reticulum unfolded protein response (GO:0030968)3.94430524
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.93493381
23protein localization to endoplasmic reticulum (GO:0070972)3.88692380
24mannose metabolic process (GO:0006013)3.88238254
25UDP-N-acetylglucosamine metabolic process (GO:0006047)3.85663759
26rRNA methylation (GO:0031167)3.85464031
27cellular response to unfolded protein (GO:0034620)3.84631439
28ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.81856445
29regulation of cytokine production involved in inflammatory response (GO:1900015)3.79739919
30DNA deamination (GO:0045006)3.77858915
31regulation of vitamin D biosynthetic process (GO:0060556)3.71788373
32proline biosynthetic process (GO:0006561)3.71252342
33cellular response to topologically incorrect protein (GO:0035967)3.70367077
34ER-nucleus signaling pathway (GO:0006984)3.58333992
35intestinal absorption (GO:0050892)3.58157483
36rRNA modification (GO:0000154)3.55310195
37regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.48103729
38* protein N-linked glycosylation via asparagine (GO:0018279)3.44028795
39endocrine pancreas development (GO:0031018)3.39251743
40* peptidyl-asparagine modification (GO:0018196)3.38895332
41sequestering of metal ion (GO:0051238)3.34835542
42response to endoplasmic reticulum stress (GO:0034976)3.33512597
43ribosomal small subunit assembly (GO:0000028)3.32031546
44NIK/NF-kappaB signaling (GO:0038061)3.21263130
45ER overload response (GO:0006983)3.20749390
46purine ribonucleotide transport (GO:0015868)3.17086795
47pteridine-containing compound biosynthetic process (GO:0042559)3.17041990
48DNA replication checkpoint (GO:0000076)3.16699650
49folic acid-containing compound biosynthetic process (GO:0009396)3.13979350
50* protein N-linked glycosylation (GO:0006487)3.12194757
51CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.11786270
52regulation of apoptotic process involved in morphogenesis (GO:1902337)3.11706944
53vesicle coating (GO:0006901)3.10157661
54DNA strand renaturation (GO:0000733)3.09943333
55negative regulation of cell aging (GO:0090344)3.08897552
56response to ATP (GO:0033198)3.06889137
57programmed necrotic cell death (GO:0097300)3.04519758
58response to unfolded protein (GO:0006986)3.03186793
59viral transcription (GO:0019083)3.02652775
60regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01215066
61translational termination (GO:0006415)2.96860274
62protein autoprocessing (GO:0016540)2.94306596
63response to topologically incorrect protein (GO:0035966)2.93755694
64peptide hormone processing (GO:0016486)2.93094274
65mitochondrial calcium ion transport (GO:0006851)2.87200974
66* GDP-mannose metabolic process (GO:0019673)2.86327570
67glutathione biosynthetic process (GO:0006750)2.82926827
68leukocyte apoptotic process (GO:0071887)2.82760253
69cellular response to virus (GO:0098586)2.81546200
70translation (GO:0006412)2.81465228
71peptidyl-glutamic acid carboxylation (GO:0017187)2.80517945
72protein carboxylation (GO:0018214)2.80517945
73protein targeting to membrane (GO:0006612)2.78011675
74maturation of 5.8S rRNA (GO:0000460)2.76888672
75proline metabolic process (GO:0006560)2.76545055
76nucleoside transmembrane transport (GO:1901642)2.75847000
77translational elongation (GO:0006414)2.75648424
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75278782
79ER to Golgi vesicle-mediated transport (GO:0006888)2.74719258
80negative regulation of viral release from host cell (GO:1902187)2.74518332
814-hydroxyproline metabolic process (GO:0019471)2.72899458
82* nucleotide-sugar biosynthetic process (GO:0009226)2.72149970
83antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70217953
84nucleotide transmembrane transport (GO:1901679)2.70182723
85antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.67635761
86adenine nucleotide transport (GO:0051503)2.67438959
87cell redox homeostasis (GO:0045454)2.65805178
88regulation of translational termination (GO:0006449)2.64975050
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64951514
90regulation of defense response to virus by host (GO:0050691)2.63519384
91digestion (GO:0007586)2.63487436
92positive regulation of protein kinase C signaling (GO:0090037)2.62824449
93necroptotic process (GO:0070266)2.61757342
94positive regulation of keratinocyte differentiation (GO:0045618)2.61042399
95ribosomal small subunit biogenesis (GO:0042274)2.60578295
96N-acetylneuraminate metabolic process (GO:0006054)2.59649588
97positive regulation of defense response to virus by host (GO:0002230)2.59051798
98erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56963724
99L-phenylalanine metabolic process (GO:0006558)2.56963724
100response to testosterone (GO:0033574)2.56718693
101zinc ion transport (GO:0006829)2.55700129
102meiotic chromosome segregation (GO:0045132)2.55237915
103galactose catabolic process (GO:0019388)2.53689768
104cellular zinc ion homeostasis (GO:0006882)2.53126274
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52969394
106intestinal epithelial cell development (GO:0060576)2.52439197
107regulation of viral release from host cell (GO:1902186)2.51805462
108necrotic cell death (GO:0070265)2.50498987
109viral life cycle (GO:0019058)2.49627109
110translational initiation (GO:0006413)2.49626789
111pseudouridine synthesis (GO:0001522)2.48982536
112purine nucleotide salvage (GO:0032261)2.48624476
113nonribosomal peptide biosynthetic process (GO:0019184)2.47739283
114positive regulation of T cell mediated cytotoxicity (GO:0001916)2.47366788
115regulation of chemokine biosynthetic process (GO:0045073)2.47261656
116mitotic cell cycle arrest (GO:0071850)2.46883855
117sphingomyelin metabolic process (GO:0006684)2.46842420
118transcytosis (GO:0045056)2.46499967
119mannosylation (GO:0097502)2.43204424
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41978724
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41978724
122nuclear envelope reassembly (GO:0031468)2.41335545
123mitotic nuclear envelope reassembly (GO:0007084)2.41335545
124valine metabolic process (GO:0006573)2.40857819
125purine nucleotide transport (GO:0015865)2.37818239
126myeloid dendritic cell differentiation (GO:0043011)2.36793641
127positive regulation of Cdc42 GTPase activity (GO:0043089)2.36503095
128lymphocyte apoptotic process (GO:0070227)2.36155604
129L-methionine salvage (GO:0071267)2.35909731
130L-methionine biosynthetic process (GO:0071265)2.35909731
131amino acid salvage (GO:0043102)2.35909731
132regulation of mitochondrial translation (GO:0070129)2.34941535
133adenosine receptor signaling pathway (GO:0001973)2.34165409
134nucleobase-containing small molecule interconversion (GO:0015949)2.33589800
135negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.33526087
136diol metabolic process (GO:0034311)2.31937307
137positive regulation of chemokine biosynthetic process (GO:0045080)2.31549231
138regulation of vitamin metabolic process (GO:0030656)2.31404799
139* nucleotide-sugar metabolic process (GO:0009225)2.30921114
140pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.30766280
141UMP biosynthetic process (GO:0006222)2.30766280
142pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.30766280
143UMP metabolic process (GO:0046049)2.30766280
144pyrimidine-containing compound transmembrane transport (GO:0072531)2.30071353
145positive regulation of triglyceride biosynthetic process (GO:0010867)2.30002890
146T cell apoptotic process (GO:0070231)2.29757677
147glandular epithelial cell differentiation (GO:0002067)2.29164451
148* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.28687404
149heme biosynthetic process (GO:0006783)2.28146072
150erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.27871660
151L-phenylalanine catabolic process (GO:0006559)2.27871660
152cellular protein complex disassembly (GO:0043624)2.27019841
153tRNA modification (GO:0006400)2.26544606
154protein-cofactor linkage (GO:0018065)2.25942337
155folic acid metabolic process (GO:0046655)2.25664563
156negative regulation of cell size (GO:0045792)2.25586161
157negative regulation of B cell apoptotic process (GO:0002903)2.24983475
158regulation of type B pancreatic cell apoptotic process (GO:2000674)2.24791075
159L-alpha-amino acid transmembrane transport (GO:1902475)2.24465934
160peptidyl-proline hydroxylation (GO:0019511)2.24226768
161maturation of SSU-rRNA (GO:0030490)2.22021405
162activation of NF-kappaB-inducing kinase activity (GO:0007250)2.18738564
163sphingosine metabolic process (GO:0006670)2.18567638
164regulation of T cell mediated cytotoxicity (GO:0001914)2.18019472
165negative regulation of response to biotic stimulus (GO:0002832)2.17441105
166response to type I interferon (GO:0034340)2.16479981
167regulation of podosome assembly (GO:0071801)2.15551250
168regulation of B cell apoptotic process (GO:0002902)2.15444841
169T cell lineage commitment (GO:0002360)2.13913459
170G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.10711784
171defense response to protozoan (GO:0042832)2.10562678
172type I interferon signaling pathway (GO:0060337)2.09534627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14402487
2GABP_17652178_ChIP-ChIP_JURKAT_Human2.99721118
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90784707
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90078058
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89501810
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85702613
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.83404612
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83214088
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.63989773
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.57198048
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46189040
12LXR_22292898_ChIP-Seq_THP-1_Human2.44010287
13* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40106105
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.36971761
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18287191
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17368536
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.14681623
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.05627257
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02771766
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.01151286
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.95699949
22RACK7_27058665_Chip-Seq_MCF-7_Human1.94090116
23DCP1A_22483619_ChIP-Seq_HELA_Human1.93755437
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85168346
25P68_20966046_ChIP-Seq_HELA_Human1.84622933
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84327225
27VDR_23849224_ChIP-Seq_CD4+_Human1.82492694
28MAF_26560356_Chip-Seq_TH1_Human1.80837658
29MAF_26560356_Chip-Seq_TH2_Human1.79184139
30* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78879798
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77069288
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.77055622
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.75623129
34MYC_19030024_ChIP-ChIP_MESCs_Mouse1.73868374
35VDR_24763502_ChIP-Seq_THP-1_Human1.71511490
36* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71464889
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70812900
38* TET1_21451524_ChIP-Seq_MESCs_Mouse1.69166871
39GABP_19822575_ChIP-Seq_HepG2_Human1.68438746
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66580310
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.66136482
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61472163
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59856128
44HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.59697548
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58623519
46XRN2_22483619_ChIP-Seq_HELA_Human1.57645589
47* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57333108
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56185999
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.55640498
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54815674
51BCOR_27268052_Chip-Seq_Bcells_Human1.54687084
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52577483
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49803762
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49786459
55EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49164087
56BCL6_27268052_Chip-Seq_Bcells_Human1.48930432
57GATA1_22025678_ChIP-Seq_K562_Human1.48531128
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48162880
59FOXP3_21729870_ChIP-Seq_TREG_Human1.46390792
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46012428
61RARB_24833708_ChIP-Seq_LIVER_Mouse1.44926681
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.43094621
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.40639537
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39740257
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37834045
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.37306904
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36287156
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35858134
69PHF8_20622854_ChIP-Seq_HELA_Human1.35741674
70E2F1_20622854_ChIP-Seq_HELA_Human1.34884149
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34722782
72UTX_26944678_Chip-Seq_JUKART_Human1.34398813
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33503978
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33291284
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.31664831
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.31417065
77KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30934400
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.30548774
79* TFEB_21752829_ChIP-Seq_HELA_Human1.30516836
80CIITA_25753668_ChIP-Seq_RAJI_Human1.29983111
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.28858813
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27080152
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27062033
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.26115187
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25642874
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24903250
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24691244
88SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23924640
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.22735324
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22540225
91YY1_21170310_ChIP-Seq_MESCs_Mouse1.22215104
92KDM2B_26808549_Chip-Seq_DND41_Human1.22090588
93* SPI1_23547873_ChIP-Seq_NB4_Human1.21485767
94SMC4_20622854_ChIP-Seq_HELA_Human1.20870071
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19718452
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.18931428
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18535803
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18351638
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18094055
100CLOCK_20551151_ChIP-Seq_293T_Human1.18054072
101TCF7_22412390_ChIP-Seq_EML_Mouse1.17487542
102TP53_22127205_ChIP-Seq_IMR90_Human1.17428005
103RARA_24833708_ChIP-Seq_LIVER_Mouse1.17348081
104RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17259129
105SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16725991
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16129149
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16030023
108SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15434403
109CTCF_21964334_Chip-Seq_Bcells_Human1.15021548
110* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13576956
111ZNF263_19887448_ChIP-Seq_K562_Human1.13556039
112PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13263251
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13228667
114MYC_22102868_ChIP-Seq_BL_Human1.13065559
115E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11830212
116ELK1_19687146_ChIP-ChIP_HELA_Human1.11736930
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11422738
118HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11089792
119KDM5A_27292631_Chip-Seq_BREAST_Human1.11062417
120* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11052920
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.10610120
122RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10496556
123SA1_27219007_Chip-Seq_Bcells_Human1.10015842
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09801956
125E2F7_22180533_ChIP-Seq_HELA_Human1.09417117
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09346903
127BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09177567
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08420899
129SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08109171
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08025065
131CREB1_26743006_Chip-Seq_LNCaP_Human1.07009867
132RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06009101
133MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.04650792
134STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04557530
135NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03113626
136TTF2_22483619_ChIP-Seq_HELA_Human1.03111021
137ATF3_27146783_Chip-Seq_COLON_Human1.02926203
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01468759
139BP1_19119308_ChIP-ChIP_Hs578T_Human1.00808443
140* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.00798084
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99652950
142ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99338525
143VDR_21846776_ChIP-Seq_THP-1_Human0.97733239
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95799057
145MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95212301
146GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93889594
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93816097
148THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93812940
149TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91585960
150CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91487103
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89474978
152FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.87411882

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption3.36500111
2MP0005220_abnormal_exocrine_pancreas3.04526266
3MP0005451_abnormal_body_composition2.83617568
4MP0002877_abnormal_melanocyte_morpholog2.79296104
5MP0005083_abnormal_biliary_tract2.69968990
6MP0010234_abnormal_vibrissa_follicle2.63428953
7MP0005365_abnormal_bile_salt2.59821822
8MP0002139_abnormal_hepatobiliary_system2.58257278
9MP0002693_abnormal_pancreas_physiology2.50939144
10MP0005360_urolithiasis2.49194566
11MP0003195_calcinosis2.35735244
12MP0003693_abnormal_embryo_hatching2.33576255
13MP0006054_spinal_hemorrhage2.33130526
14MP0005076_abnormal_cell_differentiation2.30758770
15MP0003806_abnormal_nucleotide_metabolis2.24730817
16MP0008438_abnormal_cutaneous_collagen2.13942114
17MP0005085_abnormal_gallbladder_physiolo2.11459219
18MP0001944_abnormal_pancreas_morphology2.05964910
19MP0003453_abnormal_keratinocyte_physiol1.92251093
20MP0003436_decreased_susceptibility_to1.90616303
21MP0009840_abnormal_foam_cell1.90493240
22MP0003111_abnormal_nucleus_morphology1.90221754
23MP0010386_abnormal_urinary_bladder1.86875276
24MP0003724_increased_susceptibility_to1.84581021
25MP0003705_abnormal_hypodermis_morpholog1.82751718
26MP0005171_absent_coat_pigmentation1.81022831
27MP0005174_abnormal_tail_pigmentation1.80674996
28MP0000003_abnormal_adipose_tissue1.62494576
29MP0000013_abnormal_adipose_tissue1.59544065
30MP0009643_abnormal_urine_homeostasis1.55042715
31MP0005058_abnormal_lysosome_morphology1.54713750
32MP0002148_abnormal_hypersensitivity_rea1.53274390
33MP0009333_abnormal_splenocyte_physiolog1.49531349
34MP0002138_abnormal_hepatobiliary_system1.49113387
35MP0003186_abnormal_redox_activity1.48908156
36MP0004264_abnormal_extraembryonic_tissu1.48239476
37MP0003868_abnormal_feces_composition1.47514380
38MP0003300_gastrointestinal_ulcer1.41363057
39MP0005084_abnormal_gallbladder_morpholo1.40575042
40MP0009785_altered_susceptibility_to1.40269822
41MP0003183_abnormal_peptide_metabolism1.39454793
42MP0005310_abnormal_salivary_gland1.38903863
43MP0000015_abnormal_ear_pigmentation1.37303557
44MP0001533_abnormal_skeleton_physiology1.35064623
45MP0000490_abnormal_crypts_of1.34306677
46MP0002254_reproductive_system_inflammat1.33555518
47MP0005501_abnormal_skin_physiology1.32320057
48MP0000858_altered_metastatic_potential1.31352769
49MP0003252_abnormal_bile_duct1.30622128
50MP0001845_abnormal_inflammatory_respons1.29714159
51MP0004043_abnormal_pH_regulation1.29408221
52MP0003283_abnormal_digestive_organ1.27657157
53MP0005636_abnormal_mineral_homeostasis1.27191902
54MP0008469_abnormal_protein_level1.26707499
55MP0000613_abnormal_salivary_gland1.25509998
56MP0003866_abnormal_defecation1.24766711
57MP0010155_abnormal_intestine_physiology1.23939906
58MP0001542_abnormal_bone_strength1.23701318
59MP0000685_abnormal_immune_system1.22917889
60MP0003566_abnormal_cell_adhesion1.21288015
61MP0003656_abnormal_erythrocyte_physiolo1.19297048
62MP0005408_hypopigmentation1.19137440
63MP0005000_abnormal_immune_tolerance1.18620483
64MP0000678_abnormal_parathyroid_gland1.17741377
65MP0005025_abnormal_response_to1.15914020
66MP0001216_abnormal_epidermal_layer1.15386068
67MP0001661_extended_life_span1.15258136
68MP0010352_gastrointestinal_tract_polyps1.14649676
69MP0003448_altered_tumor_morphology1.13623599
70MP0005023_abnormal_wound_healing1.11458516
71MP0005257_abnormal_intraocular_pressure1.10604301
72MP0002078_abnormal_glucose_homeostasis1.10224453
73MP0001756_abnormal_urination1.09294241
74MP0005671_abnormal_response_to1.09067421
75MP0005319_abnormal_enzyme/_coenzyme1.08752112
76MP0005332_abnormal_amino_acid1.08750415
77MP0003763_abnormal_thymus_physiology1.08324803
78MP0002419_abnormal_innate_immunity1.07455379
79MP0005584_abnormal_enzyme/coenzyme_acti1.06346555
80MP0003091_abnormal_cell_migration1.05911549
81MP0002019_abnormal_tumor_incidence1.05153626
82MP0000609_abnormal_liver_physiology1.04944836
83MP0001764_abnormal_homeostasis1.04655725
84MP0003303_peritoneal_inflammation1.04366825
85MP0001835_abnormal_antigen_presentation1.04313461
86MP0002166_altered_tumor_susceptibility1.04128134
87MP0009379_abnormal_foot_pigmentation1.04127258
88MP0004858_abnormal_nervous_system1.03413807
89MP0003172_abnormal_lysosome_physiology1.03048237
90MP0000470_abnormal_stomach_morphology1.02472501
91MP0010094_abnormal_chromosome_stability1.02369414
92MP0003795_abnormal_bone_structure1.02215040
93MP0002876_abnormal_thyroid_physiology1.01136205
94MP0004947_skin_inflammation1.01076524
95MP0009278_abnormal_bone_marrow1.00963760
96MP0002060_abnormal_skin_morphology1.00911463
97MP0005275_abnormal_skin_tensile1.00454528
98MP0003077_abnormal_cell_cycle0.99611534
99MP0001986_abnormal_taste_sensitivity0.98352719
100MP0001881_abnormal_mammary_gland0.97880769
101MP0001958_emphysema0.97685850
102MP0002006_tumorigenesis0.97147359
103MP0003718_maternal_effect0.96851223
104MP0010329_abnormal_lipoprotein_level0.96815250
105MP0003786_premature_aging0.96480460
106MP0002796_impaired_skin_barrier0.96138923
107MP0000538_abnormal_urinary_bladder0.95669529
108MP0009931_abnormal_skin_appearance0.94691579
109MP0005409_darkened_coat_color0.94651267
110MP0001243_abnormal_dermal_layer0.94521672
111MP0008875_abnormal_xenobiotic_pharmacok0.94323937
112MP0005390_skeleton_phenotype0.93190799
113MP0001873_stomach_inflammation0.93057530
114MP0002405_respiratory_system_inflammati0.92653555
115MP0005503_abnormal_tendon_morphology0.92562109
116MP0002933_joint_inflammation0.92474728
117MP0000358_abnormal_cell_content/0.92330413
118MP0004782_abnormal_surfactant_physiolog0.91154291
119MP0002723_abnormal_immune_serum0.90638600
120MP0002452_abnormal_antigen_presenting0.89467255
121MP0001790_abnormal_immune_system0.89041778
122MP0005387_immune_system_phenotype0.89041778
123MP0003045_fibrosis0.88959795
124MP0004957_abnormal_blastocyst_morpholog0.88298924
125MP0010307_abnormal_tumor_latency0.88076468
126MP0004019_abnormal_vitamin_homeostasis0.88070737
127MP0002429_abnormal_blood_cell0.87931163
128MP0002136_abnormal_kidney_physiology0.86970040
129MP0002398_abnormal_bone_marrow0.86796068
130MP0002896_abnormal_bone_mineralization0.86358715
131MP0002722_abnormal_immune_system0.84121892
132MP0002118_abnormal_lipid_homeostasis0.83998859
133MP0003279_aneurysm0.82984365
134MP0001765_abnormal_ion_homeostasis0.82980660
135MP0000716_abnormal_immune_system0.82486951
136MP0005464_abnormal_platelet_physiology0.80467530
137MP0008004_abnormal_stomach_pH0.80256017
138MP0001800_abnormal_humoral_immune0.80173919
139MP0001819_abnormal_immune_cell0.79676649
140MP0002420_abnormal_adaptive_immunity0.78728125
141MP0000598_abnormal_liver_morphology0.77564414
142MP0005379_endocrine/exocrine_gland_phen0.77440875

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.01222586
2Abnormality of the intrinsic pathway (HP:0010989)4.19704013
3Thin bony cortex (HP:0002753)4.19471173
4Poikiloderma (HP:0001029)3.92772200
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.86742464
6Conjugated hyperbilirubinemia (HP:0002908)3.82924731
7Vacuolated lymphocytes (HP:0001922)3.62325201
8Abnormality of the common coagulation pathway (HP:0010990)3.51505057
9Hypoglycemic coma (HP:0001325)3.51110893
10Ulnar bowing (HP:0003031)3.28886583
11Trismus (HP:0000211)3.22366164
12Squamous cell carcinoma (HP:0002860)3.21451469
13Hemorrhage of the eye (HP:0011885)3.16309722
14Hyperinsulinemic hypoglycemia (HP:0000825)3.11538812
15Hypoglycemic seizures (HP:0002173)3.10594495
16Symptomatic seizures (HP:0011145)2.90388954
17Late onset (HP:0003584)2.84818685
18Delayed epiphyseal ossification (HP:0002663)2.79296525
19Type I transferrin isoform profile (HP:0003642)2.75864177
20Vaginal fistula (HP:0004320)2.74864254
21Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71631830
22Abnormal protein N-linked glycosylation (HP:0012347)2.71631830
23Abnormal protein glycosylation (HP:0012346)2.71631830
24Abnormal glycosylation (HP:0012345)2.71631830
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63480781
26Beaking of vertebral bodies (HP:0004568)2.63052575
27Decreased subcutaneous fat (HP:0001002)2.60658511
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56965830
29Ketoacidosis (HP:0001993)2.56727873
30Gastrointestinal infarctions (HP:0005244)2.54572067
31Intestinal fistula (HP:0100819)2.53998186
32Malnutrition (HP:0004395)2.53661448
33Hyperglycemia (HP:0003074)2.53520043
34Carpal bone hypoplasia (HP:0001498)2.51905778
35Vertebral compression fractures (HP:0002953)2.51799681
36Premature rupture of membranes (HP:0001788)2.51265784
37Progressive muscle weakness (HP:0003323)2.50260588
38Rectovaginal fistula (HP:0000143)2.46666899
39Rectal fistula (HP:0100590)2.46666899
40Hypoalbuminemia (HP:0003073)2.45666556
41Abnormal albumin level (HP:0012116)2.45666556
42Glucose intolerance (HP:0000833)2.45462026
43Abnormality of DNA repair (HP:0003254)2.44430903
44Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43047524
45Abnormality of polysaccharide metabolism (HP:0011012)2.43047524
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43047524
47Hand muscle atrophy (HP:0009130)2.42430898
48Thoracolumbar scoliosis (HP:0002944)2.42429165
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.41971576
50Mesangial abnormality (HP:0001966)2.41631845
51Dysostosis multiplex (HP:0000943)2.41515888
52Abnormality of the pancreatic islet cells (HP:0006476)2.40682179
53Abnormality of endocrine pancreas physiology (HP:0012093)2.40682179
54Abnormal trabecular bone morphology (HP:0100671)2.39703320
55Pustule (HP:0200039)2.38663976
56Abnormal hemoglobin (HP:0011902)2.38407314
57Methylmalonic aciduria (HP:0012120)2.37277639
58Nasal polyposis (HP:0100582)2.33743292
59Stridor (HP:0010307)2.33073491
60Fat malabsorption (HP:0002630)2.30885369
61Abdominal distention (HP:0003270)2.29672971
62Abnormality of the nasal mucosa (HP:0000433)2.28364788
63Absent thumb (HP:0009777)2.27909510
64Abnormality of subcutaneous fat tissue (HP:0001001)2.26277473
65Type I diabetes mellitus (HP:0100651)2.26139620
66Entropion (HP:0000621)2.22881648
67Reduced antithrombin III activity (HP:0001976)2.21821858
68Cheilitis (HP:0100825)2.20514552
69Microretrognathia (HP:0000308)2.18074444
70Exocrine pancreatic insufficiency (HP:0001738)2.17301361
71Ragged-red muscle fibers (HP:0003200)2.15963653
72Flattened epiphyses (HP:0003071)2.15697875
73Opisthotonus (HP:0002179)2.15477578
74Thrombocytosis (HP:0001894)2.14416842
75Abnormality of T cell physiology (HP:0011840)2.14144363
76Menorrhagia (HP:0000132)2.14099652
77Facial diplegia (HP:0001349)2.12918741
78Bowed forearm bones (HP:0003956)2.12810378
79Bowing of the arm (HP:0006488)2.12810378
80Prolonged partial thromboplastin time (HP:0003645)2.12081050
81Generalized aminoaciduria (HP:0002909)2.12027887
82Rib fusion (HP:0000902)2.11148952
83Joint stiffness (HP:0001387)2.10530498
84Biconcave vertebral bodies (HP:0004586)2.08723081
85Hepatic necrosis (HP:0002605)2.08147632
86Microvesicular hepatic steatosis (HP:0001414)2.07193413
87Abnormality of homocysteine metabolism (HP:0010919)2.07104907
88Homocystinuria (HP:0002156)2.07104907
89Pancreatitis (HP:0001733)2.07066642
90Abnormal pancreas size (HP:0012094)2.07003340
91Aplasia of the musculature (HP:0100854)2.06526516
92Macrocytic anemia (HP:0001972)2.06367529
93Abnormality of the distal phalanges of the toes (HP:0010182)2.05811929
94Urinary glycosaminoglycan excretion (HP:0003541)2.04187273
95Mucopolysacchariduria (HP:0008155)2.04187273
96Abnormality of pyrimidine metabolism (HP:0004353)2.03651160
97Xanthomatosis (HP:0000991)2.02481846
98Insulin resistance (HP:0000855)2.01110507
99Rough bone trabeculation (HP:0100670)1.99596330
100Abnormality of alkaline phosphatase activity (HP:0004379)1.98866786
101Intrahepatic cholestasis (HP:0001406)1.95874416
102Elevated alkaline phosphatase (HP:0003155)1.95798645
103Abnormal glucose tolerance (HP:0001952)1.95434100
104Premature graying of hair (HP:0002216)1.94583188
105Abnormal enzyme/coenzyme activity (HP:0012379)1.93615187
106Abnormality of small intestinal villus morphology (HP:0011472)1.92875175
107Villous atrophy (HP:0011473)1.92875175
108Abnormality of the anterior horn cell (HP:0006802)1.92210628
109Degeneration of anterior horn cells (HP:0002398)1.92210628
110Metaphyseal irregularity (HP:0003025)1.92184366
111Methylmalonic acidemia (HP:0002912)1.92047519
112Hyperacusis (HP:0010780)1.91617894
113Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.91284451
114Hypobetalipoproteinemia (HP:0003563)1.91125534
115Irregular vertebral endplates (HP:0003301)1.89271305
116Attenuation of retinal blood vessels (HP:0007843)1.88847435
117Protrusio acetabuli (HP:0003179)1.88495011
118Megaloblastic anemia (HP:0001889)1.86907602
119Genu recurvatum (HP:0002816)1.86750468
120Flat occiput (HP:0005469)1.86148395
121Ketosis (HP:0001946)1.84768315
122Insulin-resistant diabetes mellitus (HP:0000831)1.84517568
123Abnormality of purine metabolism (HP:0004352)1.84030132
124Abnormality of glycolipid metabolism (HP:0010969)1.83978116
125Abnormality of liposaccharide metabolism (HP:0010968)1.83978116
126Abnormality of glycosphingolipid metabolism (HP:0004343)1.83978116
127Abnormality of transition element cation homeostasis (HP:0011030)1.83816567
128Basal cell carcinoma (HP:0002671)1.83561750
129Anorexia (HP:0002039)1.82906940
130Increased serum ferritin (HP:0003281)1.81928276
131Abnormal tarsal ossification (HP:0008369)1.81671820
132Enlarged epiphyses (HP:0010580)1.81090126
133Hypertensive crisis (HP:0100735)1.80019634
134Elevated erythrocyte sedimentation rate (HP:0003565)1.79247260
135Large for gestational age (HP:0001520)1.78582999
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77742860
137Cervical subluxation (HP:0003308)1.76768588
138Multiple enchondromatosis (HP:0005701)1.75191809
139IgA deficiency (HP:0002720)1.73984307
140Emphysema (HP:0002097)1.73825927
141Gout (HP:0001997)1.73779772
142Periodontitis (HP:0000704)1.72035829
143Eczematoid dermatitis (HP:0000976)1.71929934
144Recurrent cutaneous fungal infections (HP:0011370)1.70998087
145Chronic mucocutaneous candidiasis (HP:0002728)1.70998087
146Colitis (HP:0002583)1.70549362
147Abnormality of cells of the erythroid lineage (HP:0012130)1.70160189
148Abnormality of the costochondral junction (HP:0000919)1.70075797
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70052401
150Abnormal pupillary function (HP:0007686)1.70035313
151Nonimmune hydrops fetalis (HP:0001790)1.69839766
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.69418700
153Joint hemorrhage (HP:0005261)1.68545062
154Popliteal pterygium (HP:0009756)1.68023535
155Anteriorly placed anus (HP:0001545)1.67689531
156Flat capital femoral epiphysis (HP:0003370)1.66967731
157Abnormality of nucleobase metabolism (HP:0010932)1.66809360
158Widely patent fontanelles and sutures (HP:0004492)1.66106469
159Decreased activity of mitochondrial respiratory chain (HP:0008972)1.65901405
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.65901405
161Short thumb (HP:0009778)1.65538855
162Steatorrhea (HP:0002570)1.65405990
163Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65379454
164Progressive neurologic deterioration (HP:0002344)1.65330229
165Abnormality of sulfur amino acid metabolism (HP:0004339)1.65016010
166Dicarboxylic aciduria (HP:0003215)1.64409392
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.64409392
168Abnormal epiphyseal ossification (HP:0010656)1.64388070
169Flat acetabular roof (HP:0003180)1.64126735
170Hypergonadotropic hypogonadism (HP:0000815)1.62275033
171Stomatitis (HP:0010280)1.60810887
172Thoracic kyphosis (HP:0002942)1.60797435
173Patellar aplasia (HP:0006443)1.60065570
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59561867
175Decreased circulating renin level (HP:0003351)1.59559256
176Aplasia/Hypoplasia of the patella (HP:0006498)1.56434734
177Hypoproteinemia (HP:0003075)1.55236191

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.59872875
2MAPKAPK34.55766793
3EEF2K4.07757207
4NME23.37060952
5SMG13.05227122
6BCKDK2.91952628
7TRIB32.60905235
8EIF2AK32.44370541
9ZAK2.43755330
10IRAK32.31179773
11TLK12.23302982
12PIM22.15907164
13STK161.97645432
14RPS6KB21.96737898
15PASK1.92337224
16INSRR1.75028991
17TBK11.72277607
18TESK21.71422724
19EIF2AK11.69167188
20MST41.67836223
21EPHA21.67457234
22TAOK31.66675111
23MAP3K111.65651434
24TESK11.64935359
25IRAK41.54546310
26MAP2K31.52808797
27MAP2K21.47497113
28TRPM71.44797817
29ICK1.44441100
30FLT31.39238516
31FRK1.38157010
32PRPF4B1.36241984
33BUB11.33774729
34MAPKAPK51.30928845
35JAK31.29626669
36NME11.28574085
37TSSK61.27561954
38MAP3K31.25609323
39CDK121.23283792
40MAP4K11.20821807
41VRK21.17981896
42MAPK151.14979636
43ZAP701.14633318
44IRAK11.13900640
45TYK21.11356568
46KDR1.08928310
47CDK41.08908505
48NLK1.06250206
49ARAF1.02675742
50BRAF1.00875234
51PRKD20.97903206
52SCYL20.96801725
53TAOK20.94954866
54HIPK20.93447927
55PRKCI0.92838492
56ILK0.92530250
57AURKA0.89111438
58MAP2K60.84408206
59TAOK10.84359008
60AKT30.82831119
61MAP3K140.82121393
62RPS6KA40.82104494
63NEK90.81010710
64MST1R0.80534047
65CAMK1D0.79768882
66STK100.79426775
67CDC42BPA0.79337948
68PIK3CG0.79301045
69VRK10.78221848
70FGFR40.78164428
71PBK0.77215857
72MYLK0.74541841
73RPS6KL10.74447670
74RPS6KC10.74447670
75IRAK20.73265152
76MAPK110.72019993
77PDPK10.69743758
78LMTK20.69471019
79IKBKE0.69079326
80RPS6KA60.68531965
81BLK0.68352867
82MAP3K60.67580857
83PTK60.66175772
84CHEK20.64715061
85EPHA30.64319842
86MUSK0.63504606
87IKBKB0.63030703
88MELK0.62011376
89RPS6KA20.61749525
90EPHB10.61676584
91PDK20.60900750
92MAP3K100.58783747
93SIK20.57367414
94SIK30.56758194
95BRSK20.56651086
96MET0.56383892
97CLK10.54013928
98ATR0.52810450
99MTOR0.52331464
100CSK0.51778472
101TEC0.50991407
102PDGFRA0.50732024
103WNK40.50023242
104PRKG20.48024141
105PKN20.47701135
106PTK20.47699679
107MAP3K10.47597361
108ABL20.47392135
109LIMK10.47309123
110AKT20.46942652
111SIK10.46805224
112RPS6KA50.46698815
113MAPKAPK20.45337659
114STK40.44642075
115LRRK20.44620314
116TTN0.43743912
117GRK50.43493648
118CDK70.42741612
119CDK60.42109484
120MAP3K80.40650360
121GRK60.40458629
122PIM10.40335313
123CDK80.40007270
124DYRK30.39436983
125MAP3K130.39208739
126WEE10.39160443
127MAP3K20.37890658
128DAPK30.37536150
129TTK0.36682455
130PAK10.35133241
131PAK20.33827901
132ITK0.31940919
133CHUK0.31554245
134TXK0.30367849
135BTK0.30253781
136PRKD30.30177835
137LCK0.29600128
138SRPK10.29566607
139PAK40.29488455
140LYN0.29132564
141JAK10.28639371
142AURKB0.28614431
143SYK0.27427971

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.52884225
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.58503571
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.76133621
4Folate biosynthesis_Homo sapiens_hsa007903.22787815
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.10488296
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.55016795
7Ribosome_Homo sapiens_hsa030102.51232111
8Sulfur metabolism_Homo sapiens_hsa009202.47526791
9Sulfur relay system_Homo sapiens_hsa041222.42403289
10Proteasome_Homo sapiens_hsa030502.41281653
11Fat digestion and absorption_Homo sapiens_hsa049752.30730019
12* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.08032753
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.00049534
14Selenocompound metabolism_Homo sapiens_hsa004501.84982319
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79109191
16N-Glycan biosynthesis_Homo sapiens_hsa005101.77692733
17Other glycan degradation_Homo sapiens_hsa005111.70662555
18Primary immunodeficiency_Homo sapiens_hsa053401.69917449
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57891136
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57412124
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55250595
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.53643492
23Galactose metabolism_Homo sapiens_hsa000521.47191636
24RNA polymerase_Homo sapiens_hsa030201.41996702
25Pyrimidine metabolism_Homo sapiens_hsa002401.37751207
26Protein digestion and absorption_Homo sapiens_hsa049741.34689367
27Fanconi anemia pathway_Homo sapiens_hsa034601.33118225
28Homologous recombination_Homo sapiens_hsa034401.31868262
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29857163
30Vibrio cholerae infection_Homo sapiens_hsa051101.29776368
31Legionellosis_Homo sapiens_hsa051341.26674965
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24790018
33Renin-angiotensin system_Homo sapiens_hsa046141.24484099
34Pancreatic secretion_Homo sapiens_hsa049721.23937905
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23001531
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.20265904
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19620584
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.19152441
39Antigen processing and presentation_Homo sapiens_hsa046121.18160730
40Type I diabetes mellitus_Homo sapiens_hsa049401.12524611
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11372555
42Tryptophan metabolism_Homo sapiens_hsa003801.07605102
43TNF signaling pathway_Homo sapiens_hsa046681.07134507
44One carbon pool by folate_Homo sapiens_hsa006701.06425345
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00774690
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00258756
47Hepatitis C_Homo sapiens_hsa051600.98949883
48Bladder cancer_Homo sapiens_hsa052190.98548666
49Histidine metabolism_Homo sapiens_hsa003400.96092985
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94960727
51Caffeine metabolism_Homo sapiens_hsa002320.94062840
52Oxidative phosphorylation_Homo sapiens_hsa001900.89630382
53Pentose phosphate pathway_Homo sapiens_hsa000300.89629029
54Lysosome_Homo sapiens_hsa041420.89384153
55Herpes simplex infection_Homo sapiens_hsa051680.88495580
56Vitamin digestion and absorption_Homo sapiens_hsa049770.86080640
57Autoimmune thyroid disease_Homo sapiens_hsa053200.82887646
58Glutathione metabolism_Homo sapiens_hsa004800.80103103
59Arachidonic acid metabolism_Homo sapiens_hsa005900.77447132
60Arginine and proline metabolism_Homo sapiens_hsa003300.77125483
61* Fructose and mannose metabolism_Homo sapiens_hsa000510.76941196
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76933637
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75925734
64Base excision repair_Homo sapiens_hsa034100.75675888
65Linoleic acid metabolism_Homo sapiens_hsa005910.75673962
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74109179
67Phenylalanine metabolism_Homo sapiens_hsa003600.73851558
68Pyruvate metabolism_Homo sapiens_hsa006200.73669494
69Regulation of autophagy_Homo sapiens_hsa041400.70923344
70Peroxisome_Homo sapiens_hsa041460.69403266
71Insulin resistance_Homo sapiens_hsa049310.68228905
72Rheumatoid arthritis_Homo sapiens_hsa053230.68210104
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.66135876
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65263227
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65223754
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.64143243
77Viral carcinogenesis_Homo sapiens_hsa052030.62948241
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.62857421
79Parkinsons disease_Homo sapiens_hsa050120.61920502
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61731427
81Starch and sucrose metabolism_Homo sapiens_hsa005000.61661391
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.61365214
83Asthma_Homo sapiens_hsa053100.60851476
84Graft-versus-host disease_Homo sapiens_hsa053320.60197306
85Vitamin B6 metabolism_Homo sapiens_hsa007500.60100767
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59939401
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59492125
88* Metabolic pathways_Homo sapiens_hsa011000.59009799
89Staphylococcus aureus infection_Homo sapiens_hsa051500.58319881
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58306816
91DNA replication_Homo sapiens_hsa030300.57722052
92Toxoplasmosis_Homo sapiens_hsa051450.57182544
93Influenza A_Homo sapiens_hsa051640.56756196
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55635329
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55067325
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.53751958
97Hepatitis B_Homo sapiens_hsa051610.53229919
98Arginine biosynthesis_Homo sapiens_hsa002200.52517363
99Fatty acid degradation_Homo sapiens_hsa000710.52359227
100Mismatch repair_Homo sapiens_hsa034300.51905200
101Biosynthesis of amino acids_Homo sapiens_hsa012300.51778135
102HTLV-I infection_Homo sapiens_hsa051660.50793662
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.50150394
104Purine metabolism_Homo sapiens_hsa002300.48761155
105Malaria_Homo sapiens_hsa051440.47256788
106Measles_Homo sapiens_hsa051620.47087062
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46499906
108Hematopoietic cell lineage_Homo sapiens_hsa046400.46223076
109Prion diseases_Homo sapiens_hsa050200.45002015
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44809306
111Spliceosome_Homo sapiens_hsa030400.44576133
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44453850
113Lysine degradation_Homo sapiens_hsa003100.44353906
114Complement and coagulation cascades_Homo sapiens_hsa046100.43812922
115Allograft rejection_Homo sapiens_hsa053300.43809635
116Leishmaniasis_Homo sapiens_hsa051400.42226840
117Small cell lung cancer_Homo sapiens_hsa052220.41671078
118p53 signaling pathway_Homo sapiens_hsa041150.41130262
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40827550
120beta-Alanine metabolism_Homo sapiens_hsa004100.40630233
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39558970
122Epstein-Barr virus infection_Homo sapiens_hsa051690.39090446
123Nucleotide excision repair_Homo sapiens_hsa034200.39075477
124Glycerolipid metabolism_Homo sapiens_hsa005610.38857197
125Systemic lupus erythematosus_Homo sapiens_hsa053220.38503053
126Alzheimers disease_Homo sapiens_hsa050100.38237475
127Apoptosis_Homo sapiens_hsa042100.37055360
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36946331
129Carbon metabolism_Homo sapiens_hsa012000.36857707
130Steroid biosynthesis_Homo sapiens_hsa001000.36710234
131Sphingolipid metabolism_Homo sapiens_hsa006000.36172959
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36043667
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35971136
134Osteoclast differentiation_Homo sapiens_hsa043800.35857095
135Acute myeloid leukemia_Homo sapiens_hsa052210.35404404
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34675684
137Tuberculosis_Homo sapiens_hsa051520.34277495
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32946803
139Pertussis_Homo sapiens_hsa051330.32804542
140Prostate cancer_Homo sapiens_hsa052150.32454145

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