GMDS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)6.52038913
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.30671712
3Golgi transport vesicle coating (GO:0048200)6.24529504
4COPI coating of Golgi vesicle (GO:0048205)6.24529504
5intestinal absorption (GO:0050892)6.23522209
6protein retention in ER lumen (GO:0006621)6.11775091
7regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.78030144
8maintenance of gastrointestinal epithelium (GO:0030277)5.57328112
9very-low-density lipoprotein particle assembly (GO:0034379)5.13938571
10NADH metabolic process (GO:0006734)5.05232039
11intestinal epithelial cell development (GO:0060576)4.99369353
12intestinal cholesterol absorption (GO:0030299)4.84117723
13plasma lipoprotein particle assembly (GO:0034377)4.76491393
14signal peptide processing (GO:0006465)4.54448346
15regulation of cholesterol homeostasis (GO:2000188)4.52399965
16purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.45605961
173-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.45605961
18protein-lipid complex assembly (GO:0065005)4.38114444
19low-density lipoprotein particle remodeling (GO:0034374)4.33810565
20regulation of bile acid biosynthetic process (GO:0070857)4.33284617
21digestion (GO:0007586)4.07821963
22epithelial structure maintenance (GO:0010669)4.04752036
23digestive system process (GO:0022600)4.03365659
24protein autoprocessing (GO:0016540)4.02416534
25complement activation, classical pathway (GO:0006958)3.99662705
26urea cycle (GO:0000050)3.99010952
27hepatocyte apoptotic process (GO:0097284)3.98574869
28fucose metabolic process (GO:0006004)3.98369880
29galactose catabolic process (GO:0019388)3.95253768
30exocrine pancreas development (GO:0031017)3.91322785
31regulation of cholesterol esterification (GO:0010872)3.85326818
32fucose catabolic process (GO:0019317)3.83468527
33L-fucose metabolic process (GO:0042354)3.83468527
34L-fucose catabolic process (GO:0042355)3.83468527
35O-glycan processing (GO:0016266)3.82599579
36proline metabolic process (GO:0006560)3.76230996
37diacylglycerol metabolic process (GO:0046339)3.73392159
38ribosomal small subunit assembly (GO:0000028)3.72939694
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70288911
40urea metabolic process (GO:0019627)3.69849522
41antimicrobial humoral response (GO:0019730)3.68457935
42antibacterial humoral response (GO:0019731)3.67172884
43bundle of His cell to Purkinje myocyte communication (GO:0086069)3.62792343
44* nucleotide-sugar metabolic process (GO:0009225)3.60506430
45protein targeting to ER (GO:0045047)3.60124359
46nucleoside diphosphate biosynthetic process (GO:0009133)3.57962312
47cellular response to vitamin D (GO:0071305)3.56399243
48cotranslational protein targeting to membrane (GO:0006613)3.56219714
49proline biosynthetic process (GO:0006561)3.55118743
50fat-soluble vitamin biosynthetic process (GO:0042362)3.54457016
51regulation of respiratory burst (GO:0060263)3.53465816
52angiotensin maturation (GO:0002003)3.52757587
53pinocytosis (GO:0006907)3.50309799
54plasma lipoprotein particle organization (GO:0071827)3.47411548
55regulation of systemic arterial blood pressure by hormone (GO:0001990)3.47108917
56regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.47108917
57endocrine process (GO:0050886)3.47108917
58protein-lipid complex remodeling (GO:0034368)3.45681233
59macromolecular complex remodeling (GO:0034367)3.45681233
60plasma lipoprotein particle remodeling (GO:0034369)3.45681233
61glutamine family amino acid biosynthetic process (GO:0009084)3.44631139
62glandular epithelial cell differentiation (GO:0002067)3.43839423
63* nucleotide-sugar biosynthetic process (GO:0009226)3.42069865
64establishment of protein localization to endoplasmic reticulum (GO:0072599)3.39771017
65nitrogen cycle metabolic process (GO:0071941)3.39372611
66protein localization to endoplasmic reticulum (GO:0070972)3.36809393
67protein-lipid complex subunit organization (GO:0071825)3.34301687
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31059717
69regulation of complement activation (GO:0030449)3.30621666
70ethanol oxidation (GO:0006069)3.28496689
71retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.26794195
72positive regulation of pseudopodium assembly (GO:0031274)3.26720207
73regulation of protein activation cascade (GO:2000257)3.26623156
74regulation of guanylate cyclase activity (GO:0031282)3.25486587
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.24476782
76antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.24476782
77protein N-linked glycosylation via asparagine (GO:0018279)3.23752047
78fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.23539308
79peptidyl-asparagine modification (GO:0018196)3.21324849
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21041156
81endocrine pancreas development (GO:0031018)3.19796495
82regulation of apoptotic cell clearance (GO:2000425)3.16217657
83complement activation (GO:0006956)3.13720551
84positive regulation of nuclease activity (GO:0032075)3.12672309
85positive regulation of respiratory burst (GO:0060267)3.12580699
86hexose catabolic process (GO:0019320)3.10854947
87activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.10345601
88positive regulation of lipoprotein lipase activity (GO:0051006)3.10186346
89positive regulation of triglyceride lipase activity (GO:0061365)3.10186346
90lipoprotein transport (GO:0042953)3.08744661
91viral transcription (GO:0019083)3.08474574
92vitamin transmembrane transport (GO:0035461)3.07004561
93lipoprotein metabolic process (GO:0042157)3.05781497
94glucose 6-phosphate metabolic process (GO:0051156)3.05313485
95fructose metabolic process (GO:0006000)3.04723826
96desmosome organization (GO:0002934)3.04091123
97peptide catabolic process (GO:0043171)3.01877927
98protein maturation by protein folding (GO:0022417)3.01306807
99lipopolysaccharide biosynthetic process (GO:0009103)3.01301110
100pentose-phosphate shunt (GO:0006098)3.01172070
101transcytosis (GO:0045056)3.00796505
102sulfation (GO:0051923)2.98601699
103regulation of RIG-I signaling pathway (GO:0039535)2.98382286
104regulation of systemic arterial blood pressure (GO:0003073)2.97600763
105translational termination (GO:0006415)2.97566794
106phospholipid scrambling (GO:0017121)2.95352326
107regulation of cholesterol metabolic process (GO:0090181)2.94601826
108protein activation cascade (GO:0072376)2.94419488
109response to UV-C (GO:0010225)2.93527668
110regulation of nuclease activity (GO:0032069)2.91629801
111negative regulation of fibrinolysis (GO:0051918)2.90485102
112regulation of vitamin metabolic process (GO:0030656)2.90351742
113protein N-linked glycosylation (GO:0006487)2.89629485
114cellular glucuronidation (GO:0052695)2.89562462
115renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.88226478
116fucosylation (GO:0036065)2.87888486
117regulation of actin nucleation (GO:0051125)2.87326555
118ethanol metabolic process (GO:0006067)2.87115094
119COPII vesicle coating (GO:0048208)2.86284899
120telomere maintenance via semi-conservative replication (GO:0032201)2.85618703
121peptidyl-glutamic acid carboxylation (GO:0017187)2.84927491
122protein carboxylation (GO:0018214)2.84927491
123uronic acid metabolic process (GO:0006063)2.84247996
124glucuronate metabolic process (GO:0019585)2.84247996
125glomerular filtration (GO:0003094)2.84135699
126sexual reproduction (GO:0019953)2.83676462
127mitochondrial calcium ion transport (GO:0006851)2.82425073
128N-glycan processing (GO:0006491)2.82352493
129oligosaccharide biosynthetic process (GO:0009312)2.81418907
130actin filament depolymerization (GO:0030042)2.80452141
131positive regulation of cellular amine metabolic process (GO:0033240)2.80047603
132regulation of pseudopodium assembly (GO:0031272)2.79637221
133regulation of cellular extravasation (GO:0002691)2.78195415
134glutathione biosynthetic process (GO:0006750)2.77841011
135cellular response to vitamin (GO:0071295)2.77750689
136positive regulation of fatty acid biosynthetic process (GO:0045723)2.76698429
137embryonic process involved in female pregnancy (GO:0060136)2.76347823
138glycosphingolipid catabolic process (GO:0046479)2.75983418
139translational elongation (GO:0006414)2.73792301
140peptide hormone processing (GO:0016486)2.73267618
141cholesterol efflux (GO:0033344)2.72971416
142regulation of proton transport (GO:0010155)2.72912431
143glycolipid catabolic process (GO:0019377)2.72675529
144* GDP-mannose metabolic process (GO:0019673)2.71918200
145lung secretory cell differentiation (GO:0061140)2.71709341
146endoplasmic reticulum unfolded protein response (GO:0030968)2.71456282
147protein O-linked glycosylation (GO:0006493)2.70926928
148viral life cycle (GO:0019058)2.70656492
149sequestering of metal ion (GO:0051238)2.69690494
150renal filtration (GO:0097205)2.66774736
151epoxygenase P450 pathway (GO:0019373)2.66610402
152branching involved in mammary gland duct morphogenesis (GO:0060444)2.64167181
153regulation of superoxide anion generation (GO:0032928)2.63665322
154antigen processing and presentation of endogenous antigen (GO:0019883)2.62287534
155columnar/cuboidal epithelial cell development (GO:0002066)2.62095531
156cellular response to unfolded protein (GO:0034620)2.61739418
157regulation of extracellular matrix disassembly (GO:0010715)2.61069589
158purine nucleotide salvage (GO:0032261)2.59867479
159definitive hemopoiesis (GO:0060216)2.59823096
160purine ribonucleotide transport (GO:0015868)2.59486456
161NADPH regeneration (GO:0006740)2.59096452
162erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.58241213
163L-phenylalanine metabolic process (GO:0006558)2.58241213
164cellular response to topologically incorrect protein (GO:0035967)2.58160453
165flavonoid metabolic process (GO:0009812)2.57882451
166response to pheromone (GO:0019236)2.57694540
167galactose metabolic process (GO:0006012)2.56869362
168monosaccharide catabolic process (GO:0046365)2.56505473
169sulfate transmembrane transport (GO:1902358)2.56287305
170regulation of Golgi to plasma membrane protein transport (GO:0042996)2.56264400
171positive regulation of Cdc42 GTPase activity (GO:0043089)2.55860022
172ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.55481464
173DNA strand elongation involved in DNA replication (GO:0006271)2.55109781
174telomere maintenance via recombination (GO:0000722)2.54367694
175tight junction assembly (GO:0070830)2.53586437
176sulfur compound transport (GO:0072348)2.52444340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.99725847
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.14842661
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.96483157
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.30598144
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.13315589
6AR_21909140_ChIP-Seq_LNCAP_Human2.99564145
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.96838753
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.95847835
9ZNF263_19887448_ChIP-Seq_K562_Human2.78630134
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.56402903
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.52906694
12GATA4_25053715_ChIP-Seq_YYC3_Human2.44209390
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40955961
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.39293974
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.34682565
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26849846
17GATA6_25053715_ChIP-Seq_YYC3_Human2.20409399
18CLOCK_20551151_ChIP-Seq_293T_Human2.09253584
19LXR_22292898_ChIP-Seq_THP-1_Human2.08687333
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08149221
21SOX2_20726797_ChIP-Seq_SW620_Human2.06765295
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.01465855
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95264302
24* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93415092
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.90335972
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87860081
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.85487411
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81656181
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81283907
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71947410
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.71687691
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.71394596
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71380254
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69870507
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.65967404
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.65287192
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.64557464
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.63457952
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59139702
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59080290
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56658170
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56171970
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49243382
44DCP1A_22483619_ChIP-Seq_HELA_Human1.47697628
45* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.46099858
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45054309
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44977215
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.44516796
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.44423489
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44121998
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43582938
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42647282
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42561700
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41498751
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41418120
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41123650
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38223137
58ATF3_27146783_Chip-Seq_COLON_Human1.35998667
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.34537295
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34188015
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33932643
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33774605
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.31075401
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30210012
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29907031
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.29751892
67SPI1_23547873_ChIP-Seq_NB4_Human1.29619038
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.29437927
69FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29261544
70CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28499332
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28053823
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.27935193
73E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27060266
74* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26958889
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26878935
76ELK1_22589737_ChIP-Seq_MCF10A_Human1.25404190
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25248355
78XRN2_22483619_ChIP-Seq_HELA_Human1.24898931
79GABP_19822575_ChIP-Seq_HepG2_Human1.24624331
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23127169
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22883355
82MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21709537
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20555633
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20490633
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19057342
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18836029
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.18817587
88TCF7_22412390_ChIP-Seq_EML_Mouse1.18721093
89* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18346912
90TTF2_22483619_ChIP-Seq_HELA_Human1.18154672
91* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17423223
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17294522
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16022754
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14749094
95POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14411895
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14348691
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.14056438
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12705372
99VDR_21846776_ChIP-Seq_THP-1_Human1.12529348
100STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11994779
101ELK1_19687146_ChIP-ChIP_HELA_Human1.11952887
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11424936
103BCOR_27268052_Chip-Seq_Bcells_Human1.11369102
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.10785916
105BP1_19119308_ChIP-ChIP_Hs578T_Human1.10469690
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10181578
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10181578
108P68_20966046_ChIP-Seq_HELA_Human1.09644200
109TRIM28_21343339_ChIP-Seq_HEK293_Human1.09405282
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08753699
111BCL6_27268052_Chip-Seq_Bcells_Human1.08519179
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08474659
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.07962052
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07561438
115CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07555020
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07251056
117GATA1_22025678_ChIP-Seq_K562_Human1.06319788
118EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04598841
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.04466063
120MYC_22102868_ChIP-Seq_BL_Human1.04180418
121NCOR1_26117541_ChIP-Seq_K562_Human1.04006421
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03461991
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02908385
124PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02735748
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02599132
126* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02544344
127ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02080166
128VDR_23849224_ChIP-Seq_CD4+_Human1.01398185
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.01324127
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00678792
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00055680
132SRF_21415370_ChIP-Seq_HL-1_Mouse0.99931929
133RARA_24833708_ChIP-Seq_LIVER_Mouse0.99742276
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.99492219
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99343008
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.99299137
137TFEB_21752829_ChIP-Seq_HELA_Human0.99243463
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98800922
139ETS1_21867929_ChIP-Seq_TH2_Mouse0.98078306
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97925933
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97894400
142OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97664348
143CREB1_26743006_Chip-Seq_LNCaP_Human0.96841777
144CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96820343
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96529101
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96370854
147RACK7_27058665_Chip-Seq_MCF-7_Human0.96227455
148PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96184700
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95678888
150KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95227187
151TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95124523
152VDR_24763502_ChIP-Seq_THP-1_Human0.94832267
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94194701
154STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93693902
155GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93570297
156SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92521454
157FOXP3_21729870_ChIP-Seq_TREG_Human0.91340362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.79178758
2MP0001873_stomach_inflammation4.40790620
3MP0008004_abnormal_stomach_pH3.78899821
4MP0004264_abnormal_extraembryonic_tissu3.51148695
5MP0003283_abnormal_digestive_organ3.51019500
6MP0010234_abnormal_vibrissa_follicle3.42886911
7MP0001666_abnormal_nutrient_absorption3.42880819
8MP0003866_abnormal_defecation3.35331842
9MP0000490_abnormal_crypts_of3.30730066
10MP0006054_spinal_hemorrhage3.20185327
11MP0003693_abnormal_embryo_hatching3.10448926
12MP0005085_abnormal_gallbladder_physiolo2.96634058
13MP0000462_abnormal_digestive_system2.93632893
14MP0003300_gastrointestinal_ulcer2.88826515
15MP0005451_abnormal_body_composition2.65502414
16MP0010352_gastrointestinal_tract_polyps2.55263378
17MP0001663_abnormal_digestive_system2.52080641
18MP0001664_abnormal_digestion2.47018687
19MP0009840_abnormal_foam_cell2.45530138
20MP0010155_abnormal_intestine_physiology2.45032398
21MP0003878_abnormal_ear_physiology2.44491042
22MP0005377_hearing/vestibular/ear_phenot2.44491042
23MP0005381_digestive/alimentary_phenotyp2.35317511
24MP0000477_abnormal_intestine_morphology2.12610374
25MP0005220_abnormal_exocrine_pancreas1.93453754
26MP0002166_altered_tumor_susceptibility1.82390362
27MP0004957_abnormal_blastocyst_morpholog1.78049541
28MP0000470_abnormal_stomach_morphology1.75472342
29MP0010329_abnormal_lipoprotein_level1.74083890
30MP0004858_abnormal_nervous_system1.74050247
31MP0004043_abnormal_pH_regulation1.65944835
32MP0000613_abnormal_salivary_gland1.60838483
33MP0005409_darkened_coat_color1.59784189
34MP0003183_abnormal_peptide_metabolism1.49751385
35MP0002006_tumorigenesis1.47974438
36MP0000537_abnormal_urethra_morphology1.45842895
37MP0010386_abnormal_urinary_bladder1.45043581
38MP0003705_abnormal_hypodermis_morpholog1.40866130
39MP0003436_decreased_susceptibility_to1.39292309
40MP0000678_abnormal_parathyroid_gland1.36246808
41MP0002796_impaired_skin_barrier1.35730710
42MP0003806_abnormal_nucleotide_metabolis1.35102295
43MP0009384_cardiac_valve_regurgitation1.34427456
44MP0001765_abnormal_ion_homeostasis1.32367088
45MP0000609_abnormal_liver_physiology1.31607603
46MP0002693_abnormal_pancreas_physiology1.30324001
47MP0003191_abnormal_cellular_cholesterol1.29007158
48MP0002877_abnormal_melanocyte_morpholog1.28678427
49MP0005167_abnormal_blood-brain_barrier1.28464259
50MP0005332_abnormal_amino_acid1.28020650
51MP0003868_abnormal_feces_composition1.27208834
52MP0005084_abnormal_gallbladder_morpholo1.25618680
53MP0001881_abnormal_mammary_gland1.25161221
54MP0002396_abnormal_hematopoietic_system1.24481656
55MP0005310_abnormal_salivary_gland1.23879744
56MP0009379_abnormal_foot_pigmentation1.23734471
57MP0000566_synostosis1.23487365
58MP0008260_abnormal_autophagy1.22258439
59MP0005636_abnormal_mineral_homeostasis1.18456322
60MP0009643_abnormal_urine_homeostasis1.18358403
61MP0008875_abnormal_xenobiotic_pharmacok1.18008886
62MP0000465_gastrointestinal_hemorrhage1.14575803
63MP0001944_abnormal_pancreas_morphology1.13860829
64MP0005076_abnormal_cell_differentiation1.13387681
65MP0003315_abnormal_perineum_morphology1.12295619
66MP0002822_catalepsy1.10836446
67MP0000013_abnormal_adipose_tissue1.09891706
68MP0000538_abnormal_urinary_bladder1.09347018
69MP0002009_preneoplasia1.09080338
70MP0005360_urolithiasis1.08198965
71MP0002132_abnormal_respiratory_system1.06750347
72MP0005501_abnormal_skin_physiology1.04257560
73MP0005257_abnormal_intraocular_pressure1.03756189
74MP0005670_abnormal_white_adipose1.03627898
75MP0009333_abnormal_splenocyte_physiolog1.02902210
76MP0005319_abnormal_enzyme/_coenzyme0.99456271
77MP0002118_abnormal_lipid_homeostasis0.99400901
78MP0001764_abnormal_homeostasis0.99242119
79MP0005083_abnormal_biliary_tract0.98881301
80MP0005666_abnormal_adipose_tissue0.95442826
81MP0003329_amyloid_beta_deposits0.94810838
82MP0001849_ear_inflammation0.93666927
83MP0005584_abnormal_enzyme/coenzyme_acti0.92775969
84MP0003303_peritoneal_inflammation0.91458261
85MP0008469_abnormal_protein_level0.90495907
86MP0003718_maternal_effect0.90310810
87MP0001845_abnormal_inflammatory_respons0.88108936
88MP0002060_abnormal_skin_morphology0.88038252
89MP0004185_abnormal_adipocyte_glucose0.86499218
90MP0004947_skin_inflammation0.86161210
91MP0004484_altered_response_of0.84900778
92MP0005165_increased_susceptibility_to0.83716006
93MP0004272_abnormal_basement_membrane0.83511757
94MP0003566_abnormal_cell_adhesion0.81537430
95MP0001730_embryonic_growth_arrest0.80609572
96MP0003453_abnormal_keratinocyte_physiol0.80430390
97MP0004808_abnormal_hematopoietic_stem0.78871986
98MP0009278_abnormal_bone_marrow0.78732902
99MP0003075_altered_response_to0.77943578
100MP0003763_abnormal_thymus_physiology0.77724175
101MP0000604_amyloidosis0.75055753
102MP0000598_abnormal_liver_morphology0.74382921
103MP0000681_abnormal_thyroid_gland0.73759616
104MP0000858_altered_metastatic_potential0.73097212
105MP0001216_abnormal_epidermal_layer0.70936830
106MP0003724_increased_susceptibility_to0.70569074
107MP0010307_abnormal_tumor_latency0.70125200
108MP0009642_abnormal_blood_homeostasis0.69982144
109MP0000627_abnormal_mammary_gland0.69957855
110MP0003795_abnormal_bone_structure0.69726200
111MP0004147_increased_porphyrin_level0.69525379
112MP0003943_abnormal_hepatobiliary_system0.69298213
113MP0004019_abnormal_vitamin_homeostasis0.69095434
114MP0001533_abnormal_skeleton_physiology0.68854416
115MP0009785_altered_susceptibility_to0.67200696
116MP0001756_abnormal_urination0.65978639
117MP0002896_abnormal_bone_mineralization0.65926248
118MP0002909_abnormal_adrenal_gland0.65568886
119MP0004782_abnormal_surfactant_physiolog0.64260757
120MP0002019_abnormal_tumor_incidence0.63698053
121MP0008438_abnormal_cutaneous_collagen0.61119438
122MP0001835_abnormal_antigen_presentation0.59712876
123MP0002098_abnormal_vibrissa_morphology0.59696092
124MP0005025_abnormal_response_to0.59658633
125MP0002452_abnormal_antigen_presenting0.58478073
126MP0005365_abnormal_bile_salt0.58376210
127MP0001819_abnormal_immune_cell0.58194707
128MP0002420_abnormal_adaptive_immunity0.57331328
129MP0002136_abnormal_kidney_physiology0.56622105
130MP0005023_abnormal_wound_healing0.55968094
131MP0002148_abnormal_hypersensitivity_rea0.55807707
132MP0003123_paternal_imprinting0.55325640
133MP0005058_abnormal_lysosome_morphology0.55129832
134MP0003252_abnormal_bile_duct0.54503991
135MP0005408_hypopigmentation0.53571205
136MP0003077_abnormal_cell_cycle0.50958628
137MP0005464_abnormal_platelet_physiology0.50248163
138MP0000003_abnormal_adipose_tissue0.49342322
139MP0003111_abnormal_nucleus_morphology0.49071238
140MP0005166_decreased_susceptibility_to0.49059802
141MP0000350_abnormal_cell_proliferation0.49022976
142MP0002089_abnormal_postnatal_growth/wei0.48906904
143MP0002163_abnormal_gland_morphology0.48701885

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.95965772
2Abnormality of glutamine family amino acid metabolism (HP:0010902)4.64306385
3Systemic lupus erythematosus (HP:0002725)4.60245433
4Microretrognathia (HP:0000308)4.42049735
5Hemorrhage of the eye (HP:0011885)4.17554181
6Ileus (HP:0002595)4.14006566
7Complement deficiency (HP:0004431)3.90000395
8Right ventricular cardiomyopathy (HP:0011663)3.89663004
9Petechiae (HP:0000967)3.82892612
10Abnormality of complement system (HP:0005339)3.73888013
11Hypobetalipoproteinemia (HP:0003563)3.70128752
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.67573535
13Malnutrition (HP:0004395)3.64482057
14Flat acetabular roof (HP:0003180)3.46598834
15Symptomatic seizures (HP:0011145)3.39283899
16Glomerulonephritis (HP:0000099)3.36471778
17Abdominal distention (HP:0003270)3.33526364
18Cupped ribs (HP:0000887)3.25429729
19Villous atrophy (HP:0011473)3.23905873
20Abnormality of small intestinal villus morphology (HP:0011472)3.23905873
21Thrombocytosis (HP:0001894)3.16512486
22Fat malabsorption (HP:0002630)3.10975777
23Hydroxyprolinuria (HP:0003080)3.04505904
24Abnormality of proline metabolism (HP:0010907)3.04505904
25Abnormal pancreas size (HP:0012094)3.04356873
26Xanthomatosis (HP:0000991)2.99199338
27Hyperactive renin-angiotensin system (HP:0000841)2.98799470
28Prolonged partial thromboplastin time (HP:0003645)2.94273434
29Micronodular cirrhosis (HP:0001413)2.92110943
30Type I transferrin isoform profile (HP:0003642)2.89309962
31Aplastic anemia (HP:0001915)2.82885015
32Abnormal protein N-linked glycosylation (HP:0012347)2.80096321
33Abnormal protein glycosylation (HP:0012346)2.80096321
34Abnormal glycosylation (HP:0012345)2.80096321
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.80096321
36Acanthocytosis (HP:0001927)2.79768288
37Widely patent fontanelles and sutures (HP:0004492)2.73014405
38Vacuolated lymphocytes (HP:0001922)2.71070292
39Abnormality of cells of the erythroid lineage (HP:0012130)2.70685786
40Flattened epiphyses (HP:0003071)2.69250334
41Abnormal tarsal ossification (HP:0008369)2.67680134
42Abnormal number of erythroid precursors (HP:0012131)2.65511934
43Wide cranial sutures (HP:0010537)2.64397737
44Palpitations (HP:0001962)2.63380623
45Thoracolumbar scoliosis (HP:0002944)2.62757396
46Purpura (HP:0000979)2.59021973
47Flat capital femoral epiphysis (HP:0003370)2.58643900
48Spinal cord compression (HP:0002176)2.56239253
49Conjugated hyperbilirubinemia (HP:0002908)2.55971845
50Abnormal foot bone ossification (HP:0010675)2.55752946
51Abnormal biliary tract morphology (HP:0012440)2.53102441
52Abnormality of the 1st metacarpal (HP:0010009)2.50701209
53Intrahepatic cholestasis (HP:0001406)2.49422320
54Mucopolysacchariduria (HP:0008155)2.48913566
55Urinary glycosaminoglycan excretion (HP:0003541)2.48913566
56Hypoglycemic seizures (HP:0002173)2.48088098
57Reduced antithrombin III activity (HP:0001976)2.47462018
58Hyperammonemia (HP:0001987)2.47065118
59Hyperinsulinemic hypoglycemia (HP:0000825)2.46814711
60Nonimmune hydrops fetalis (HP:0001790)2.45549582
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.44093214
62Nephritis (HP:0000123)2.42507732
63Cervical subluxation (HP:0003308)2.42288809
64Hypoglycemic coma (HP:0001325)2.40985177
65Abnormality of carpal bone ossification (HP:0006257)2.40670651
66Abnormality of chloride homeostasis (HP:0011422)2.40667327
67Joint hemorrhage (HP:0005261)2.35013684
68Late onset (HP:0003584)2.34590153
69Thin bony cortex (HP:0002753)2.34433598
70Gout (HP:0001997)2.31803559
71Gastrointestinal dysmotility (HP:0002579)2.31189413
72Beaking of vertebral bodies (HP:0004568)2.29994413
73Abnormality of T cell physiology (HP:0011840)2.29170152
74Hypercholesterolemia (HP:0003124)2.29118979
75Abnormality of the common coagulation pathway (HP:0010990)2.28464371
76Hypotension (HP:0002615)2.27823300
77Exocrine pancreatic insufficiency (HP:0001738)2.27126435
78Vertebral compression fractures (HP:0002953)2.27102676
79Irregular epiphyses (HP:0010582)2.26815831
80Autoimmune thrombocytopenia (HP:0001973)2.26408752
81Biliary tract neoplasm (HP:0100574)2.26031915
82Hyperparathyroidism (HP:0000843)2.24839133
83Rectal prolapse (HP:0002035)2.21889306
84Growth hormone excess (HP:0000845)2.21226443
85Abnormality of polysaccharide metabolism (HP:0011012)2.21140513
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21140513
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21140513
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.19654502
89Pustule (HP:0200039)2.19268921
90Abnormality of the distal phalanx of the thumb (HP:0009617)2.18728715
91Abnormality of the 2nd finger (HP:0004100)2.18281355
92Vascular calcification (HP:0004934)2.16677582
93Tetany (HP:0001281)2.16375240
94Hypolipoproteinemia (HP:0010981)2.15804889
95Pili torti (HP:0003777)2.14776928
96Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13204660
97Amyloidosis (HP:0011034)2.11766970
98Menorrhagia (HP:0000132)2.09713410
99Abnormal hemoglobin (HP:0011902)2.08341008
100Glomerulosclerosis (HP:0000096)2.08206341
101Alkalosis (HP:0001948)2.06517302
102Severe short stature (HP:0003510)2.05327442
103Pigmentary retinal degeneration (HP:0001146)2.05188364
104Seborrheic dermatitis (HP:0001051)2.03281806
105Eczematoid dermatitis (HP:0000976)2.03224002
106Hypoplasia of the uterus (HP:0000013)2.02486620
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01303502
108Fragile skin (HP:0001030)2.00042575
109Dysostosis multiplex (HP:0000943)1.99894469
110Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.97486469
111Vertebral hypoplasia (HP:0008417)1.97486469
112Coxa vara (HP:0002812)1.97242370
113Reticulocytopenia (HP:0001896)1.96505239
114Chronic diarrhea (HP:0002028)1.96332042
115Generalized aminoaciduria (HP:0002909)1.94414775
116Autoimmune hemolytic anemia (HP:0001890)1.94380947
117Decreased circulating renin level (HP:0003351)1.93825365
118Focal segmental glomerulosclerosis (HP:0000097)1.93653016
119Nausea (HP:0002018)1.92604727
120Symphalangism affecting the phalanges of the hand (HP:0009773)1.92205874
121Abnormality of the lumbar spine (HP:0100712)1.91441308
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91188610
123Abnormality of the acetabulum (HP:0003170)1.88755151
124Abnormality of the gastric mucosa (HP:0004295)1.88659218
125Abnormal ossification of hand bones (HP:0005921)1.88028646
12611 pairs of ribs (HP:0000878)1.88014904
127Abnormality of purine metabolism (HP:0004352)1.87165539
128Cardiovascular calcification (HP:0011915)1.86741471
129Hypoplasia of the pons (HP:0012110)1.86486922
130Abnormal hair laboratory examination (HP:0003328)1.86347649
131Protrusio acetabuli (HP:0003179)1.85913266
132Uterine neoplasm (HP:0010784)1.85638281
133Increased serum pyruvate (HP:0003542)1.85561318
134Abnormality of nucleobase metabolism (HP:0010932)1.85516546
135Abnormal enzyme/coenzyme activity (HP:0012379)1.84501998
136Abnormality of renin-angiotensin system (HP:0000847)1.84171091
137Abnormality of the Achilles tendon (HP:0005109)1.84070501
138IgM deficiency (HP:0002850)1.83735177
139Neoplasm of the rectum (HP:0100743)1.83031206
140Genu varum (HP:0002970)1.82183846
141Insulin resistance (HP:0000855)1.81998454
142Abnormality of pyrimidine metabolism (HP:0004353)1.81918743
143Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81720099
144Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81720099
145Abnormality of glycolysis (HP:0004366)1.81398234
146Abnormal hand bone ossification (HP:0010660)1.80738211
147Atrophic scars (HP:0001075)1.80315277
148Increased purine levels (HP:0004368)1.80192583
149Hyperuricemia (HP:0002149)1.80192583
150Ragged-red muscle fibers (HP:0003200)1.79967124
151Small epiphyses (HP:0010585)1.79889373
152Segmental peripheral demyelination/remyelination (HP:0003481)1.79416637
153Hyperphosphatemia (HP:0002905)1.79220983
154Gingival bleeding (HP:0000225)1.78760769
155Abnormality of alkaline phosphatase activity (HP:0004379)1.78071196
156Subcapsular cataract (HP:0000523)1.77302478
157Gastrointestinal inflammation (HP:0004386)1.77278183
158Aortic aneurysm (HP:0004942)1.76583614
159Abnormality of the intrinsic pathway (HP:0010989)1.76203780
160Hepatic necrosis (HP:0002605)1.74802728
161Ureteral stenosis (HP:0000071)1.73458950
162Proximal tubulopathy (HP:0000114)1.72359341
163Abnormality of dicarboxylic acid metabolism (HP:0010995)1.71833044
164Dicarboxylic aciduria (HP:0003215)1.71833044
165Congenital sensorineural hearing impairment (HP:0008527)1.71638781
166Mildly elevated creatine phosphokinase (HP:0008180)1.69414160
167Short middle phalanx of finger (HP:0005819)1.69395606
168Neonatal short-limb short stature (HP:0008921)1.69249264
169Cerebral palsy (HP:0100021)1.69163925
170Metabolic alkalosis (HP:0200114)1.68895375
171Steatorrhea (HP:0002570)1.67957656
172Hypophosphatemia (HP:0002148)1.64530518
173Polygenic inheritance (HP:0010982)1.63810162
174Hyponatremia (HP:0002902)1.63315205
175Colitis (HP:0002583)1.63115378
176Rhabdomyolysis (HP:0003201)1.61413889
177Hyperglycinuria (HP:0003108)1.60862515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.49716880
2FGFR43.60793988
3MST1R3.50146342
4FRK3.48968443
5MST43.20636078
6RIPK13.15130069
7LMTK23.13960410
8MAP2K22.88621632
9NME22.84581981
10TEC2.37358647
11SMG12.36221655
12PASK2.36141320
13TAOK32.23656826
14CDK122.22893500
15PIK3CA2.20378095
16ERN12.18197576
17ICK2.15044079
18PRKG22.07338369
19EEF2K1.91208279
20SCYL21.68571746
21TESK11.67913455
22FGFR31.67343427
23NME11.67163049
24PKN21.51437664
25IRAK31.44566114
26CAMK1D1.41122978
27PIM21.37499866
28TESK21.33539662
29PTK61.30658150
30FLT31.29306317
31RPS6KB21.29260315
32NUAK11.29131374
33PIK3CG1.27673297
34EIF2AK31.22079150
35PRPF4B1.21977093
36BMX1.21530316
37GRK11.20213249
38MAP3K81.14219574
39SIK11.12789911
40PRKCI1.10900826
41MAPKAPK31.09294013
42PAK41.04818324
43MAP3K21.04229928
44STK391.02527815
45MET1.01487478
46STK100.99966375
47EPHA20.99046425
48ERBB40.98672198
49MYLK0.97162021
50BCKDK0.96401241
51AURKB0.94124060
52TTK0.93576215
53PDPK10.92903199
54EPHB10.92050987
55LRRK20.91411400
56VRK10.89673643
57NEK20.88414591
58INSRR0.87161534
59TRIB30.86311609
60MAP2K10.84730831
61KDR0.84211483
62VRK20.83483710
63BRAF0.83109121
64EIF2AK10.82835317
65TAOK20.82409887
66LATS10.81733987
67MAP4K10.80729292
68TBK10.78673893
69DAPK10.78232472
70CDC42BPA0.72718488
71CDK60.71547687
72MAP2K60.71263306
73MAP3K140.69931804
74STK240.68800465
75MAP3K110.68289593
76ZAP700.68168902
77TRPM70.65762831
78BRSK20.65447733
79PBK0.64818944
80CDC70.64106332
81MAP3K120.60783780
82STK160.59970779
83DDR20.59851805
84ABL20.58457264
85TGFBR10.58259026
86RPS6KA40.58208247
87RET0.58167801
88PDK20.57939990
89WEE10.57790927
90MAP3K10.56887947
91PTK20.56857532
92MATK0.56850502
93IRAK40.55958825
94TGFBR20.55734407
95PDK10.55651296
96JAK30.55425492
97CDK90.55252509
98GRK60.53839820
99CSF1R0.52962552
100CDK40.50371633
101RIPK40.49470860
102ACVR1B0.49040088
103MAP2K30.47870351
104CAMKK20.47645215
105MAPKAPK20.47513043
106BTK0.44700116
107HIPK20.44470626
108CDK80.43959418
109NEK10.43799135
110MAP3K30.41216561
111MAP3K100.39086142
112PRKAA20.39060897
113CDK70.37554549
114ARAF0.37236856
115PAK20.36831162
116MTOR0.36147145
117DYRK1B0.35976361
118MAPK150.34580814
119SRC0.32910145
120KSR20.32194543
121PLK10.32146914
122TAOK10.31458836
123CCNB10.31082625
124EPHB20.30524554
125NEK90.28787285
126PAK10.26984291
127SRPK10.25597836
128MAPK110.25114837
129ERBB20.24732954
130TYK20.24732878
131LIMK10.24631324
132ALK0.24361944
133CAMKK10.24355238
134WNK40.24131023
135PDGFRA0.23639628
136EPHA30.23288559
137RPS6KB10.23029461
138CSNK2A20.22762988
139FER0.21706633

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.85531445
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.95849029
3Protein export_Homo sapiens_hsa030603.01936838
4Arginine biosynthesis_Homo sapiens_hsa002202.73395338
5Fat digestion and absorption_Homo sapiens_hsa049752.67659302
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.62018631
7* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.58158567
8DNA replication_Homo sapiens_hsa030302.47379901
9Mineral absorption_Homo sapiens_hsa049782.44058878
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42323932
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.39256471
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37908620
13N-Glycan biosynthesis_Homo sapiens_hsa005102.33020470
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.23034350
15Galactose metabolism_Homo sapiens_hsa000522.18502512
16Renin-angiotensin system_Homo sapiens_hsa046142.08498443
17Ribosome_Homo sapiens_hsa030102.02861732
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93680501
19Pancreatic secretion_Homo sapiens_hsa049721.90951033
20Other glycan degradation_Homo sapiens_hsa005111.88336970
21Complement and coagulation cascades_Homo sapiens_hsa046101.87408335
22Folate biosynthesis_Homo sapiens_hsa007901.87285751
23Protein digestion and absorption_Homo sapiens_hsa049741.85425044
24Mismatch repair_Homo sapiens_hsa034301.84320900
25Sulfur relay system_Homo sapiens_hsa041221.70214091
26Fatty acid degradation_Homo sapiens_hsa000711.68002038
27PPAR signaling pathway_Homo sapiens_hsa033201.52261134
28Arginine and proline metabolism_Homo sapiens_hsa003301.50042888
29Biosynthesis of amino acids_Homo sapiens_hsa012301.50014480
30Staphylococcus aureus infection_Homo sapiens_hsa051501.49406844
31Phenylalanine metabolism_Homo sapiens_hsa003601.41919618
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.41591506
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38672130
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32720530
35Fatty acid biosynthesis_Homo sapiens_hsa000611.31634942
36Base excision repair_Homo sapiens_hsa034101.31546804
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26033037
38Chemical carcinogenesis_Homo sapiens_hsa052041.25362796
39Glutathione metabolism_Homo sapiens_hsa004801.21604010
40Pentose phosphate pathway_Homo sapiens_hsa000301.19537586
41Retinol metabolism_Homo sapiens_hsa008301.15289405
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14518776
43Homologous recombination_Homo sapiens_hsa034401.14274917
44Fatty acid metabolism_Homo sapiens_hsa012121.14252290
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.10546751
46Asthma_Homo sapiens_hsa053101.10375571
47* Fructose and mannose metabolism_Homo sapiens_hsa000511.09106586
48Antigen processing and presentation_Homo sapiens_hsa046121.05114312
49Pyrimidine metabolism_Homo sapiens_hsa002401.03404485
50Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00979394
51Vibrio cholerae infection_Homo sapiens_hsa051100.98870551
52Legionellosis_Homo sapiens_hsa051340.98375351
53Thyroid cancer_Homo sapiens_hsa052160.96887663
54Tyrosine metabolism_Homo sapiens_hsa003500.95951867
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.93803128
56Vitamin digestion and absorption_Homo sapiens_hsa049770.92641326
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91280111
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91110534
59Cell cycle_Homo sapiens_hsa041100.90202168
60Starch and sucrose metabolism_Homo sapiens_hsa005000.88979008
61Thyroid hormone synthesis_Homo sapiens_hsa049180.86752188
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86718320
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82921770
64Sphingolipid metabolism_Homo sapiens_hsa006000.81957193
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.81263488
66Oxidative phosphorylation_Homo sapiens_hsa001900.81197663
67Bladder cancer_Homo sapiens_hsa052190.79940284
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76394242
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76386206
70Parkinsons disease_Homo sapiens_hsa050120.74759032
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73225931
72Linoleic acid metabolism_Homo sapiens_hsa005910.72079174
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.70780740
74Bile secretion_Homo sapiens_hsa049760.70037508
75Peroxisome_Homo sapiens_hsa041460.68846992
76Selenocompound metabolism_Homo sapiens_hsa004500.65943355
77Fatty acid elongation_Homo sapiens_hsa000620.65392483
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.65294049
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64280410
80Nucleotide excision repair_Homo sapiens_hsa034200.64259898
81Caffeine metabolism_Homo sapiens_hsa002320.64135793
82Arachidonic acid metabolism_Homo sapiens_hsa005900.63858297
83Purine metabolism_Homo sapiens_hsa002300.61230918
84Allograft rejection_Homo sapiens_hsa053300.59998925
85Alzheimers disease_Homo sapiens_hsa050100.58902300
86Pyruvate metabolism_Homo sapiens_hsa006200.58717703
87Autoimmune thyroid disease_Homo sapiens_hsa053200.53370326
88Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52740048
89Histidine metabolism_Homo sapiens_hsa003400.51902549
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51472298
91Graft-versus-host disease_Homo sapiens_hsa053320.51346357
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50544013
93Tight junction_Homo sapiens_hsa045300.49749413
94Apoptosis_Homo sapiens_hsa042100.48178799
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48030072
96HIF-1 signaling pathway_Homo sapiens_hsa040660.47792543
97Influenza A_Homo sapiens_hsa051640.46972864
98p53 signaling pathway_Homo sapiens_hsa041150.45145649
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.45085724
100RNA degradation_Homo sapiens_hsa030180.42852638
101Leishmaniasis_Homo sapiens_hsa051400.42805309
102Nitrogen metabolism_Homo sapiens_hsa009100.42473632
103Huntingtons disease_Homo sapiens_hsa050160.42011611
104Pertussis_Homo sapiens_hsa051330.41470986
105Adherens junction_Homo sapiens_hsa045200.40845213
106Prion diseases_Homo sapiens_hsa050200.40813749
107Hepatitis C_Homo sapiens_hsa051600.40800228
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40736878
109Tryptophan metabolism_Homo sapiens_hsa003800.40196341
110Insulin resistance_Homo sapiens_hsa049310.39188561
111Proteasome_Homo sapiens_hsa030500.38647819
112One carbon pool by folate_Homo sapiens_hsa006700.38553606
113Salmonella infection_Homo sapiens_hsa051320.36958016
114Hematopoietic cell lineage_Homo sapiens_hsa046400.36906746
115Toxoplasmosis_Homo sapiens_hsa051450.36494000
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36142249
117Small cell lung cancer_Homo sapiens_hsa052220.35577869
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34871233
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.34173377
120Gastric acid secretion_Homo sapiens_hsa049710.33257400
121Shigellosis_Homo sapiens_hsa051310.32639818
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.32085998
123* Metabolic pathways_Homo sapiens_hsa011000.31138007
124Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30984425
125Hepatitis B_Homo sapiens_hsa051610.30966170
126Herpes simplex infection_Homo sapiens_hsa051680.30009966
127Glycerolipid metabolism_Homo sapiens_hsa005610.29901262
128ECM-receptor interaction_Homo sapiens_hsa045120.29560681
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28660606
130Viral carcinogenesis_Homo sapiens_hsa052030.28425369
131Platelet activation_Homo sapiens_hsa046110.27712057
132Insulin secretion_Homo sapiens_hsa049110.27539677
133Viral myocarditis_Homo sapiens_hsa054160.27370843
134Type I diabetes mellitus_Homo sapiens_hsa049400.26817955
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.26523202
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26096253
137Acute myeloid leukemia_Homo sapiens_hsa052210.23844019
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.23295569
139Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23265026
140Prolactin signaling pathway_Homo sapiens_hsa049170.22675832
141Carbon metabolism_Homo sapiens_hsa012000.22245548
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.21825014
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21300643
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21139677

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