GM2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.37846111
2amino sugar catabolic process (GO:0046348)5.17547936
3positive regulation by symbiont of host defense response (GO:0052509)4.96976618
4modulation by symbiont of host defense response (GO:0052031)4.96976618
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.96976618
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.96976618
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.96976618
8modulation by symbiont of host immune response (GO:0052553)4.96976618
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94016083
10cellular response to exogenous dsRNA (GO:0071360)4.93927635
11cellular response to thyroid hormone stimulus (GO:0097067)4.75552250
12immunoglobulin mediated immune response (GO:0016064)4.67253829
13negative regulation of interleukin-12 production (GO:0032695)4.62822310
14positive regulation of interferon-alpha production (GO:0032727)4.61275327
15* glycosphingolipid catabolic process (GO:0046479)4.54210227
16response to peptidoglycan (GO:0032494)4.50881490
17regulation of cholesterol storage (GO:0010885)4.40515861
18respiratory burst (GO:0045730)4.39752705
19regulation of interferon-alpha production (GO:0032647)4.37186841
20positive regulation of monocyte chemotaxis (GO:0090026)4.35152236
21cellular response to interferon-alpha (GO:0035457)4.33091643
22production of molecular mediator involved in inflammatory response (GO:0002532)4.10687561
23regulation of mononuclear cell migration (GO:0071675)4.06820870
24* glycolipid catabolic process (GO:0019377)4.02411590
25cellular response to interferon-beta (GO:0035458)3.99238560
26regulation of T cell chemotaxis (GO:0010819)3.97858847
27positive regulation of T cell chemotaxis (GO:0010820)3.97858847
28interferon-gamma secretion (GO:0072643)3.96367819
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.87852905
30macrophage activation involved in immune response (GO:0002281)3.86344711
31T-helper 1 type immune response (GO:0042088)3.85325404
32antigen processing and presentation of endogenous antigen (GO:0019883)3.84050249
33regulation of interferon-beta biosynthetic process (GO:0045357)3.82822399
34response to thyroid hormone (GO:0097066)3.79340999
35regulation of B cell receptor signaling pathway (GO:0050855)3.77977416
36regulation of vitamin D biosynthetic process (GO:0060556)3.77641635
37hydrogen peroxide biosynthetic process (GO:0050665)3.76752970
38microglial cell activation (GO:0001774)3.74826423
39granulocyte activation (GO:0036230)3.67493298
40neutrophil activation (GO:0042119)3.66925410
41* oligosaccharide catabolic process (GO:0009313)3.66162000
42regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.59669731
43reactive oxygen species biosynthetic process (GO:1903409)3.59451936
44positive regulation of chemokine biosynthetic process (GO:0045080)3.58817472
45positive regulation of antigen processing and presentation (GO:0002579)3.55094679
46regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54108350
47positive regulation of gamma-delta T cell activation (GO:0046645)3.52430804
48pinocytosis (GO:0006907)3.52113069
49* ceramide catabolic process (GO:0046514)3.51221597
50superoxide anion generation (GO:0042554)3.48568640
51N-acetylneuraminate metabolic process (GO:0006054)3.47484554
52positive regulation of leukocyte degranulation (GO:0043302)3.46732548
53negative regulation of nitric oxide biosynthetic process (GO:0045019)3.45011771
54positive regulation of T cell migration (GO:2000406)3.44254407
55B cell mediated immunity (GO:0019724)3.42650011
56lipopolysaccharide-mediated signaling pathway (GO:0031663)3.40681828
57regulation of monocyte chemotaxis (GO:0090025)3.39502917
58positive regulation of cellular amide metabolic process (GO:0034250)3.38376932
59cytokine secretion (GO:0050663)3.36239657
60regulation of RIG-I signaling pathway (GO:0039535)3.34245814
61response to interferon-alpha (GO:0035455)3.34182526
62intracellular pH reduction (GO:0051452)3.30406941
63detection of other organism (GO:0098543)3.30394171
64positive regulation of interferon-beta production (GO:0032728)3.26707504
65response to interferon-beta (GO:0035456)3.24005852
66positive regulation of lymphocyte migration (GO:2000403)3.23852336
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.22429466
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.22336967
69response to host immune response (GO:0052572)3.22336967
70myeloid cell activation involved in immune response (GO:0002275)3.21871516
71barbed-end actin filament capping (GO:0051016)3.21193262
72interferon-gamma-mediated signaling pathway (GO:0060333)3.20893852
73defense response to protozoan (GO:0042832)3.20390694
74positive regulation of mast cell activation (GO:0033005)3.19907428
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.19814172
76regulation of podosome assembly (GO:0071801)3.19263376
77regulation of chemokine biosynthetic process (GO:0045073)3.18606268
78osteoclast differentiation (GO:0030316)3.18579846
79protein localization to endosome (GO:0036010)3.16690250
80regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16615768
81positive regulation of mast cell degranulation (GO:0043306)3.15651983
82positive regulation of mast cell activation involved in immune response (GO:0033008)3.15651983
83fat-soluble vitamin biosynthetic process (GO:0042362)3.15107769
84cellular extravasation (GO:0045123)3.14814357
85leukocyte mediated cytotoxicity (GO:0001909)3.14576434
86regulation of antigen processing and presentation (GO:0002577)3.14379788
87regulation of mast cell degranulation (GO:0043304)3.12922418
88glucosamine-containing compound catabolic process (GO:1901072)3.10748933
89lymphocyte mediated immunity (GO:0002449)3.10372548
90* membrane lipid catabolic process (GO:0046466)3.09065581
91monocyte chemotaxis (GO:0002548)3.08685111
92positive regulation of cholesterol efflux (GO:0010875)3.08366111
93macrophage activation (GO:0042116)3.08058913
94regulation of lymphocyte chemotaxis (GO:1901623)3.06992185
95positive regulation of interleukin-12 production (GO:0032735)3.04809606
96regulation of mast cell activation (GO:0033003)3.04716116
97regulation of superoxide anion generation (GO:0032928)3.04665137
98natural killer cell mediated cytotoxicity (GO:0042267)3.04646981
99natural killer cell mediated immunity (GO:0002228)3.04646981
100type I interferon signaling pathway (GO:0060337)3.03798702
101cellular response to type I interferon (GO:0071357)3.03798702
102detection of external biotic stimulus (GO:0098581)3.03559015
103regulation of B cell differentiation (GO:0045577)3.03412200
104apoptotic cell clearance (GO:0043277)3.01292638
105response to protozoan (GO:0001562)3.01186395
106detection of bacterium (GO:0016045)3.01084305
107regulation of T cell migration (GO:2000404)3.00658486
108NIK/NF-kappaB signaling (GO:0038061)2.99442406
109regulation of leukocyte degranulation (GO:0043300)2.99156559
110dendritic cell differentiation (GO:0097028)2.97961855
111regulation of vitamin metabolic process (GO:0030656)2.96879970
112response to type I interferon (GO:0034340)2.96814580
113positive regulation of bone resorption (GO:0045780)2.96694853
114positive regulation of bone remodeling (GO:0046852)2.96694853
115regulation of lymphocyte migration (GO:2000401)2.94788442
116* sphingolipid catabolic process (GO:0030149)2.93731835
117T cell migration (GO:0072678)2.92031900
118mannose metabolic process (GO:0006013)2.91915940
119peptide catabolic process (GO:0043171)2.91098860
120response to muramyl dipeptide (GO:0032495)2.91040262
121keratan sulfate catabolic process (GO:0042340)2.90487613
122regulation of macrophage chemotaxis (GO:0010758)2.89438684
123adhesion of symbiont to host cell (GO:0044650)2.89222625
124virion attachment to host cell (GO:0019062)2.89222625
125eosinophil chemotaxis (GO:0048245)2.89170548
126actin nucleation (GO:0045010)2.88217299
127epithelial cell differentiation involved in prostate gland development (GO:0060742)2.88146318
128phagosome maturation (GO:0090382)2.87847581
129germinal center formation (GO:0002467)2.86393795
130mast cell activation (GO:0045576)2.85508613
131regulation of monocyte differentiation (GO:0045655)2.84596142
132regulation of mast cell activation involved in immune response (GO:0033006)2.84218313
133positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.83408665
134lipoxygenase pathway (GO:0019372)2.83358032
135negative regulation of interleukin-17 production (GO:0032700)2.82311076
136positive regulation of type 2 immune response (GO:0002830)2.81302311
137negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80425310
138regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.80104237
139positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.80058519
140positive regulation of tissue remodeling (GO:0034105)2.79740182
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78651663
142regulation of cytokine secretion involved in immune response (GO:0002739)2.77436952
143cellular response to zinc ion (GO:0071294)2.76824055
144response to host (GO:0075136)2.76391575
145response to host defenses (GO:0052200)2.76391575
146response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76391575
147antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75730489
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75730489
149myeloid dendritic cell activation (GO:0001773)2.75279820
150regulation of membrane protein ectodomain proteolysis (GO:0051043)2.74877246
151detection of molecule of bacterial origin (GO:0032490)2.74417855
152negative regulation of mast cell activation (GO:0033004)2.74272648
153positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.74247195
154myeloid dendritic cell differentiation (GO:0043011)2.72567783
155myeloid leukocyte activation (GO:0002274)2.71896056
156regulation of activation of Janus kinase activity (GO:0010533)2.70700861
157adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.70379082
158negative regulation of growth of symbiont in host (GO:0044130)2.69371301
159negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.69371301
160regulation of growth of symbiont in host (GO:0044126)2.69371301
161positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.66707024
162decidualization (GO:0046697)2.66667097
163adhesion of symbiont to host (GO:0044406)2.66562711
164regulation of myeloid leukocyte mediated immunity (GO:0002886)2.66477734
165macrophage differentiation (GO:0030225)2.65910222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse7.24990994
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.50550767
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.47866085
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.20492578
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.04836300
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42311701
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.25118500
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23860847
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05279483
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.01260367
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.95543975
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88823689
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.77958966
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61953352
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.58708121
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43750073
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40867021
18* SPI1_23547873_ChIP-Seq_NB4_Human2.29352376
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28603005
20* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18679344
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04442503
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02543013
23* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90653430
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88038826
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86619150
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85412672
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78783736
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.78130881
29MYB_26560356_Chip-Seq_TH2_Human1.70992366
30CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70089325
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.65579705
32* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61498490
33LXR_22292898_ChIP-Seq_THP-1_Human1.57204545
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56044799
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.51898505
36E2F7_22180533_ChIP-Seq_HELA_Human1.51746397
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49877028
38* PU_27001747_Chip-Seq_BMDM_Mouse1.49156750
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48365363
40PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.46971579
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44482610
42RUNX_20019798_ChIP-Seq_JUKART_Human1.44377835
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42348554
44* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.42203955
45CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42065172
46MYB_26560356_Chip-Seq_TH1_Human1.41825630
47SCL_19346495_ChIP-Seq_HPC-7_Human1.39025916
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.38958479
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36136765
50MAF_26560356_Chip-Seq_TH1_Human1.35758450
51EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33874278
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33446243
53VDR_24763502_ChIP-Seq_THP-1_Human1.31958787
54SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31895753
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31778296
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31095584
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30712770
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29168234
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.27961586
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.25554819
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24435897
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22817410
63GATA3_26560356_Chip-Seq_TH2_Human1.22388330
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22134584
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21723325
66TP63_17297297_ChIP-ChIP_HaCaT_Human1.20003548
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.19874360
68SPI1_23127762_ChIP-Seq_K562_Human1.18559732
69* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17510281
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17202847
71GATA1_19941826_ChIP-Seq_K562_Human1.15535820
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14335625
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14115459
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14035404
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11123725
76MYC_22102868_ChIP-Seq_BL_Human1.08397168
77TCF7_22412390_ChIP-Seq_EML_Mouse1.07966017
78CLOCK_20551151_ChIP-Seq_293T_Human1.06956997
79* GATA3_27048872_Chip-Seq_THYMUS_Human1.05492926
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05215630
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05076279
82* VDR_24787735_ChIP-Seq_THP-1_Human1.04491190
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04456671
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03585647
85PPARA_22158963_ChIP-Seq_LIVER_Mouse1.03393262
86KDM2B_26808549_Chip-Seq_DND41_Human1.00996544
87EGR1_19032775_ChIP-ChIP_M12_Human0.97716017
88P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95329370
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95226616
90RXR_22158963_ChIP-Seq_LIVER_Mouse0.95122556
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90536261
92VDR_21846776_ChIP-Seq_THP-1_Human0.90527144
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.88823263
94KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88677333
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88382845
96RACK7_27058665_Chip-Seq_MCF-7_Human0.88281963
97GATA1_22025678_ChIP-Seq_K562_Human0.87289209
98CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87283782
99STAT1_20625510_ChIP-Seq_HELA_Human0.87256620
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86844765
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85451760
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85307967
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.83829119
104KDM2B_26808549_Chip-Seq_K562_Human0.83550717
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83508209
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83508209
107TFEB_21752829_ChIP-Seq_HELA_Human0.83059526
108TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82979260
109SOX2_20726797_ChIP-Seq_SW620_Human0.82432846
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81239658
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.80886992
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80633392
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79581090
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.78530128
115VDR_23849224_ChIP-Seq_CD4+_Human0.77726823
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76284425
117STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75904700
118* SRF_21415370_ChIP-Seq_HL-1_Mouse0.74777804
119GABP_17652178_ChIP-ChIP_JURKAT_Human0.74125216
120UTX_26944678_Chip-Seq_JUKART_Human0.73248998
121LXR_22158963_ChIP-Seq_LIVER_Mouse0.72519467
122E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.72137300
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.70909089
124MAF_26560356_Chip-Seq_TH2_Human0.70351258
125ELK1_19687146_ChIP-ChIP_HELA_Human0.69469979
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.69186165
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67512622
128FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.66715477
129EST1_17652178_ChIP-ChIP_JURKAT_Human0.66619591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.77481130
2MP0002148_abnormal_hypersensitivity_rea3.73614307
3MP0003436_decreased_susceptibility_to3.51276116
4MP0009785_altered_susceptibility_to3.37880675
5MP0005671_abnormal_response_to3.04215299
6MP0002419_abnormal_innate_immunity3.01798140
7MP0005000_abnormal_immune_tolerance2.92185083
8MP0005025_abnormal_response_to2.89837696
9MP0006082_CNS_inflammation2.85163681
10MP0001853_heart_inflammation2.65156366
11MP0002452_abnormal_antigen_presenting2.58303948
12MP0000685_abnormal_immune_system2.53693983
13MP0009840_abnormal_foam_cell2.51572340
14MP0001790_abnormal_immune_system2.49970436
15MP0005387_immune_system_phenotype2.49970436
16MP0005058_abnormal_lysosome_morphology2.40325844
17MP0003195_calcinosis2.34083676
18MP0001800_abnormal_humoral_immune2.30832950
19MP0002723_abnormal_immune_serum2.29436342
20MP0003724_increased_susceptibility_to2.28739613
21MP0003300_gastrointestinal_ulcer2.24921829
22MP0001819_abnormal_immune_cell2.23358806
23MP0002420_abnormal_adaptive_immunity2.15187641
24MP0003303_peritoneal_inflammation2.06114499
25MP0004510_myositis2.02674320
26MP0005464_abnormal_platelet_physiology1.88634648
27MP0003329_amyloid_beta_deposits1.86296742
28MP0001845_abnormal_inflammatory_respons1.75508106
29MP0003453_abnormal_keratinocyte_physiol1.73638676
30MP0009764_decreased_sensitivity_to1.71124906
31MP0002405_respiratory_system_inflammati1.70644503
32MP0009333_abnormal_splenocyte_physiolog1.68388831
33MP0002006_tumorigenesis1.67698958
34MP0000343_altered_response_to1.62436289
35MP0001533_abnormal_skeleton_physiology1.61241477
36MP0008469_abnormal_protein_level1.60446300
37MP0002877_abnormal_melanocyte_morpholog1.59226693
38MP0004782_abnormal_surfactant_physiolog1.57871036
39MP0003186_abnormal_redox_activity1.56931425
40MP0003172_abnormal_lysosome_physiology1.56631284
41MP0000716_abnormal_immune_system1.53282572
42MP0010155_abnormal_intestine_physiology1.51014204
43MP0003806_abnormal_nucleotide_metabolis1.49660503
44MP0005310_abnormal_salivary_gland1.48881011
45MP0003448_altered_tumor_morphology1.46410314
46MP0005075_abnormal_melanosome_morpholog1.42948536
47MP0002398_abnormal_bone_marrow1.42806215
48MP0002166_altered_tumor_susceptibility1.41176909
49MP0005257_abnormal_intraocular_pressure1.39969805
50MP0003075_altered_response_to1.35312572
51MP0008260_abnormal_autophagy1.32012515
52MP0005397_hematopoietic_system_phenotyp1.29541413
53MP0001545_abnormal_hematopoietic_system1.29541413
54MP0003191_abnormal_cellular_cholesterol1.29391016
55MP0002254_reproductive_system_inflammat1.28504107
56MP0000689_abnormal_spleen_morphology1.28468472
57MP0002429_abnormal_blood_cell1.24520089
58MP0000858_altered_metastatic_potential1.23140296
59MP0000920_abnormal_myelination1.23000385
60MP0004019_abnormal_vitamin_homeostasis1.22855955
61MP0004947_skin_inflammation1.22366867
62MP0002722_abnormal_immune_system1.18783012
63MP0002998_abnormal_bone_remodeling1.17489765
64MP0005365_abnormal_bile_salt1.16668736
65MP0002876_abnormal_thyroid_physiology1.14563900
66MP0010234_abnormal_vibrissa_follicle1.14501294
67MP0003690_abnormal_glial_cell1.13111921
68MP0004381_abnormal_hair_follicle1.12532203
69MP0008004_abnormal_stomach_pH1.12194490
70MP0003656_abnormal_erythrocyte_physiolo1.11450344
71MP0006054_spinal_hemorrhage1.06148638
72MP0003866_abnormal_defecation1.05277447
73MP0005166_decreased_susceptibility_to1.03329705
74MP0002090_abnormal_vision1.00319652
75MP0009278_abnormal_bone_marrow1.00060853
76MP0003091_abnormal_cell_migration0.98422460
77MP0002138_abnormal_hepatobiliary_system0.95912009
78MP0009763_increased_sensitivity_to0.94983629
79MP0002136_abnormal_kidney_physiology0.91014361
80MP0005165_increased_susceptibility_to0.86843353
81MP0002139_abnormal_hepatobiliary_system0.86827057
82MP0001881_abnormal_mammary_gland0.86705516
83MP0000490_abnormal_crypts_of0.85985300
84MP0000604_amyloidosis0.85891898
85MP0005647_abnormal_sex_gland0.84136923
86MP0003693_abnormal_embryo_hatching0.83536650
87MP0003634_abnormal_glial_cell0.82812169
88MP0005164_abnormal_response_to0.82315658
89MP0004883_abnormal_blood_vessel0.80685503
90MP0003763_abnormal_thymus_physiology0.80605467
91MP0000627_abnormal_mammary_gland0.78214987
92MP0000371_diluted_coat_color0.77820843
93MP0002796_impaired_skin_barrier0.77781661
94MP0002396_abnormal_hematopoietic_system0.77379498
95MP0003795_abnormal_bone_structure0.76970162
96MP0009643_abnormal_urine_homeostasis0.76076799
97MP0001216_abnormal_epidermal_layer0.75848904
98MP0000249_abnormal_blood_vessel0.75704484
99MP0010307_abnormal_tumor_latency0.75346854
100MP0001764_abnormal_homeostasis0.74370722
101MP0005332_abnormal_amino_acid0.73242536
102MP0001851_eye_inflammation0.73119667
103MP0005023_abnormal_wound_healing0.71456640
104MP0002168_other_aberrant_phenotype0.70724407
105MP0001756_abnormal_urination0.70019182
106MP0001849_ear_inflammation0.69923449
107MP0005319_abnormal_enzyme/_coenzyme0.69679174
108MP0005584_abnormal_enzyme/coenzyme_acti0.69087340
109MP0000383_abnormal_hair_follicle0.68953180
110MP0003183_abnormal_peptide_metabolism0.68827861
111MP0005390_skeleton_phenotype0.68302731
112MP0008057_abnormal_DNA_replication0.66380524
113MP0003828_pulmonary_edema0.66045068
114MP0001542_abnormal_bone_strength0.65880013
115MP0003566_abnormal_cell_adhesion0.65860795
116MP0000015_abnormal_ear_pigmentation0.65685989
117MP0005167_abnormal_blood-brain_barrier0.65372502
118MP0010352_gastrointestinal_tract_polyps0.65190122
119MP0003632_abnormal_nervous_system0.64383415
120MP0005395_other_phenotype0.64299097
121MP0002332_abnormal_exercise_endurance0.63009339
122MP0001958_emphysema0.62039683
123MP0008874_decreased_physiological_sensi0.61549244
124MP0000569_abnormal_digit_pigmentation0.61284426
125MP0003279_aneurysm0.60674216
126MP0000609_abnormal_liver_physiology0.60148177
127MP0000598_abnormal_liver_morphology0.59498370
128MP0005174_abnormal_tail_pigmentation0.58762686
129MP0004808_abnormal_hematopoietic_stem0.58753044
130MP0003705_abnormal_hypodermis_morpholog0.58691715
131MP0001727_abnormal_embryo_implantation0.58541065
132MP0002009_preneoplasia0.55895643
133MP0005451_abnormal_body_composition0.54847446

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.29124369
2Recurrent bacterial skin infections (HP:0005406)5.93708929
3Eczematoid dermatitis (HP:0000976)5.50405244
4Recurrent gram-negative bacterial infections (HP:0005420)5.03102031
5Increased neuronal autofluorescent lipopigment (HP:0002074)4.91850688
6Increased cerebral lipofuscin (HP:0011813)4.84631990
7Abnormality of macrophages (HP:0004311)4.82767655
8Elevated erythrocyte sedimentation rate (HP:0003565)4.54601028
9Chronic obstructive pulmonary disease (HP:0006510)4.39642965
10Obstructive lung disease (HP:0006536)4.39642965
11Vacuolated lymphocytes (HP:0001922)4.37017322
12Neurofibrillary tangles (HP:0002185)4.22664603
13Systemic lupus erythematosus (HP:0002725)4.19146169
14Myositis (HP:0100614)3.92812777
15Mediastinal lymphadenopathy (HP:0100721)3.92076240
16Abnormality of polysaccharide metabolism (HP:0011012)3.82740109
17Abnormality of glycosaminoglycan metabolism (HP:0004371)3.82740109
18Abnormality of mucopolysaccharide metabolism (HP:0011020)3.82740109
19Mutism (HP:0002300)3.78297175
20Mucopolysacchariduria (HP:0008155)3.71195344
21Urinary glycosaminoglycan excretion (HP:0003541)3.71195344
22Optic neuritis (HP:0100653)3.71144039
23Retrobulbar optic neuritis (HP:0100654)3.71144039
24Orchitis (HP:0100796)3.60532331
25Recurrent skin infections (HP:0001581)3.52627245
26Basal ganglia calcification (HP:0002135)3.34972468
27Vasculitis (HP:0002633)3.32802366
28Gingivitis (HP:0000230)3.19981544
29Autoimmune thrombocytopenia (HP:0001973)3.18644356
30Cerebral inclusion bodies (HP:0100314)3.08739421
31Recurrent fungal infections (HP:0002841)3.05412036
32Nuclear cataract (HP:0100018)3.04776681
33Loss of speech (HP:0002371)3.01276882
34Pustule (HP:0200039)2.99282966
35Meningitis (HP:0001287)2.98360160
36Petechiae (HP:0000967)2.98204956
37Upper motor neuron abnormality (HP:0002127)2.95402358
38Prolonged neonatal jaundice (HP:0006579)2.89577598
39Neuronal loss in central nervous system (HP:0002529)2.87831017
40Gastrointestinal infarctions (HP:0005244)2.84852509
41Nephritis (HP:0000123)2.84054162
42Increased IgM level (HP:0003496)2.81483128
43Periodontitis (HP:0000704)2.80196578
44Pulmonary infiltrates (HP:0002113)2.76597252
45Abnormality of complement system (HP:0005339)2.73960854
46Metaphyseal irregularity (HP:0003025)2.65333706
47Hepatosplenomegaly (HP:0001433)2.63995955
48Axonal loss (HP:0003447)2.63680155
49Recurrent viral infections (HP:0004429)2.62257274
50Interstitial pulmonary disease (HP:0006530)2.62065297
51Glomerulonephritis (HP:0000099)2.61335958
52Abnormality of the vasculature of the conjunctiva (HP:0008054)2.60172651
53Hemoptysis (HP:0002105)2.59271429
54Anorexia (HP:0002039)2.59221281
55Inappropriate behavior (HP:0000719)2.57173786
56Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.56844777
57Keratoconjunctivitis sicca (HP:0001097)2.55691263
58Chronic otitis media (HP:0000389)2.55098424
59Arterial thrombosis (HP:0004420)2.53986956
60IgM deficiency (HP:0002850)2.52174733
61Cerebral palsy (HP:0100021)2.52115322
62Nausea (HP:0002018)2.50747833
63Joint hemorrhage (HP:0005261)2.49857667
64Progressive neurologic deterioration (HP:0002344)2.48909616
65Urticaria (HP:0001025)2.47588154
66Global brain atrophy (HP:0002283)2.46109841
67Progressive visual loss (HP:0000529)2.45457848
68Cellulitis (HP:0100658)2.44629911
69Abnormality of the periventricular white matter (HP:0002518)2.44050687
70Personality changes (HP:0000751)2.42698919
71Stomatitis (HP:0010280)2.39972066
72Abnormality of the pleura (HP:0002103)2.38923073
73Recurrent pneumonia (HP:0006532)2.36026485
74Leukocytosis (HP:0001974)2.35697859
75Gingival bleeding (HP:0000225)2.34829995
76Myocardial infarction (HP:0001658)2.34006812
77Asymmetric septal hypertrophy (HP:0001670)2.32332010
78Hypergammaglobulinemia (HP:0010702)2.29532097
79Keratoconjunctivitis (HP:0001096)2.29362578
80Increased serum ferritin (HP:0003281)2.29079783
81Agnosia (HP:0010524)2.28902001
82Glomerulopathy (HP:0100820)2.28732912
83Eosinophilia (HP:0001880)2.26804101
84Granulocytopenia (HP:0001913)2.23197727
85Azoospermia (HP:0000027)2.21120209
86Recurrent cutaneous fungal infections (HP:0011370)2.19838208
87Chronic mucocutaneous candidiasis (HP:0002728)2.19838208
88Dysostosis multiplex (HP:0000943)2.18774988
89Thick nail (HP:0001805)2.16426988
90Abnormality of eosinophils (HP:0001879)2.15917135
91Cardiomegaly (HP:0001640)2.15625032
92Abnormality of the pericardium (HP:0001697)2.15540276
93* Diminished motivation (HP:0000745)2.14143523
94Osteolytic defects of the hand bones (HP:0009699)2.13285456
95Osteolytic defects of the phalanges of the hand (HP:0009771)2.13285456
96* Apathy (HP:0000741)2.13277995
97Protuberant abdomen (HP:0001538)2.12787175
98Peripheral demyelination (HP:0011096)2.12423901
99Thoracic kyphosis (HP:0002942)2.10821575
100Abnormality of the prostate (HP:0008775)2.09938012
101Xanthomatosis (HP:0000991)2.08886705
102* Dementia (HP:0000726)2.08780482
103Encephalitis (HP:0002383)2.08479929
104Amyloidosis (HP:0011034)2.08106359
105Recurrent lower respiratory tract infections (HP:0002783)2.07364690
106Cheilitis (HP:0100825)2.05826690
107Purpura (HP:0000979)2.05815830
108Supranuclear gaze palsy (HP:0000605)2.05148081
109* Poor head control (HP:0002421)2.04379875
110Pulmonary fibrosis (HP:0002206)2.02469519
111Complement deficiency (HP:0004431)2.01010692
112Skin rash (HP:0000988)1.99852117
113Retinal atrophy (HP:0001105)1.99422311
114Increased CSF protein (HP:0002922)1.99228063
115Thrombocytosis (HP:0001894)1.99213562
116Hematochezia (HP:0002573)1.99097554
117Bone pain (HP:0002653)1.98522176
118Multiple enchondromatosis (HP:0005701)1.97440986
119Osteomyelitis (HP:0002754)1.96731250
120* Abnormality of glycolipid metabolism (HP:0010969)1.96712351
121* Abnormality of liposaccharide metabolism (HP:0010968)1.96712351
122* Abnormality of glycosphingolipid metabolism (HP:0004343)1.96712351
123Acrocyanosis (HP:0001063)1.96054100
124Prostate neoplasm (HP:0100787)1.95080023
125Disinhibition (HP:0000734)1.93331060
126Skin ulcer (HP:0200042)1.92342099
127IgA deficiency (HP:0002720)1.90562773
128Pathologic fracture (HP:0002756)1.88835854
129Septate vagina (HP:0001153)1.87698368
130Premature loss of primary teeth (HP:0006323)1.87602450
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84928595
132Restrictive lung disease (HP:0002091)1.84424943
133Polyneuropathy (HP:0001271)1.83748513
134Vertebral compression fractures (HP:0002953)1.83596796
135Skin nodule (HP:0200036)1.82980358
136IgG deficiency (HP:0004315)1.82336768
137T lymphocytopenia (HP:0005403)1.81900492
138Exertional dyspnea (HP:0002875)1.77189249
139Esophageal varix (HP:0002040)1.77093040
140Malnutrition (HP:0004395)1.76551973
141Abnormality of iron homeostasis (HP:0011031)1.74339952
142Neoplasm of head and neck (HP:0012288)1.72561499
143Esophageal neoplasm (HP:0100751)1.72561499
144Increased IgE level (HP:0003212)1.72422864
145Gangrene (HP:0100758)1.71084485
146Abnormality of the lumbar spine (HP:0100712)1.70425143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.31671984
2MAP3K144.27196841
3IRAK33.95825592
4BLK3.95218866
5IRAK43.44419611
6RIPK43.21622490
7MAP4K13.10403897
8TBK12.71815834
9TYK22.68582361
10PBK2.62583634
11PIM22.56345195
12PRPF4B2.39874288
13DDR22.38078067
14TXK2.35920590
15IKBKB2.34241516
16NEK92.05873884
17JAK31.98963987
18MAP3K31.91637870
19KIT1.83525912
20IKBKE1.78285162
21ARAF1.77969838
22MAP3K121.76560379
23CSF1R1.76376324
24RIPK11.72798733
25PIM11.64132661
26MST41.61221063
27MOS1.60366600
28BMPR21.52162099
29JAK11.50957906
30CDC42BPA1.48655229
31WEE11.47676797
32ZAP701.43770416
33SYK1.43634342
34TAOK11.40054534
35CSK1.32090998
36CHUK1.29837916
37BTK1.28280886
38CAMK1D1.28054970
39ABL21.25505889
40LYN1.21573907
41TEC1.21154884
42ZAK1.20061335
43MAP3K131.19156708
44MATK1.16065646
45EIF2AK11.15669264
46BUB11.13505310
47PLK41.12344382
48MAP3K11.10108646
49CAMKK21.09156703
50TESK21.08010104
51NME21.01887602
52STK40.99947981
53STK240.96464954
54HCK0.95184559
55STK160.86119656
56JAK20.84364212
57PRKCD0.82926051
58CDK60.82294750
59MARK30.81695236
60TAOK30.80102153
61LCK0.77287073
62CLK10.76552569
63FES0.75849396
64RPS6KA20.75713490
65FLT30.74793014
66EIF2AK20.72337896
67TESK10.72159588
68ERBB30.71437391
69BMX0.71414994
70TRPM70.71138768
71YES10.70879385
72IRAK20.70446557
73PDGFRA0.69395536
74LRRK20.65664422
75MAP2K60.65374006
76MAP3K50.64350556
77MYLK0.63194118
78MAP2K30.62450312
79FGFR30.61880644
80FGFR40.61373445
81TTN0.61109455
82EPHB10.60069732
83STK100.59874249
84LIMK10.59862994
85IRAK10.59609651
86KDR0.57095844
87ERN10.56479300
88TRIB30.56339796
89SIK30.56258511
90CAMK1G0.56114118
91ITK0.55596665
92KSR20.54423137
93PIK3CG0.52212595
94ABL10.52064078
95GRK10.50250113
96TGFBR10.49955923
97PAK40.46952356
98LATS20.46848617
99TGFBR20.45368557
100ICK0.45029518
101MAP3K80.44821430
102MAPK40.43434613
103MAPK70.43085238
104MAP3K90.43008036
105EIF2AK30.42497651
106GRK70.40542002
107PRKCQ0.40496192
108MAPKAPK20.40197829
109STK30.40063069
110NUAK10.39273549
111MAPK120.38474413
112RPS6KA40.38206548
113RPS6KA60.37317538
114ADRBK20.35089712
115TYRO30.35067144
116PDGFRB0.34913372
117PDK20.34446548
118SGK30.34355088
119PDK10.33729029
120MAP3K60.33462655
121FYN0.33183676
122MST1R0.32354884
123MAP3K110.31910317
124FGR0.31382532
125PRKG20.31028970
126GRK60.30846349
127INSR0.30459220
128MAP3K20.29534013
129TAOK20.29470019
130RPS6KL10.26283866
131RPS6KC10.26283866
132RPS6KB20.25750138
133ACVR1B0.23342633
134NEK60.23041398
135PDPK10.22549966
136AKT30.22077925
137BRAF0.18604239
138RAF10.18412627

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.09846040
2Leishmaniasis_Homo sapiens_hsa051402.90971785
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.79429545
4Graft-versus-host disease_Homo sapiens_hsa053322.70173464
5Allograft rejection_Homo sapiens_hsa053302.62655791
6Legionellosis_Homo sapiens_hsa051342.51088299
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.48759416
8Proteasome_Homo sapiens_hsa030502.36153508
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.34067647
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32060080
11* Lysosome_Homo sapiens_hsa041422.30970501
12Asthma_Homo sapiens_hsa053102.29856850
13NF-kappa B signaling pathway_Homo sapiens_hsa040642.20894714
14Other glycan degradation_Homo sapiens_hsa005112.02276844
15Pertussis_Homo sapiens_hsa051331.95908568
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.94423920
17Tuberculosis_Homo sapiens_hsa051521.84740639
18Measles_Homo sapiens_hsa051621.84559768
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82690410
20Osteoclast differentiation_Homo sapiens_hsa043801.81250290
21Rheumatoid arthritis_Homo sapiens_hsa053231.74733985
22Salmonella infection_Homo sapiens_hsa051321.70403369
23Antigen processing and presentation_Homo sapiens_hsa046121.66913267
24Influenza A_Homo sapiens_hsa051641.62395327
25Malaria_Homo sapiens_hsa051441.61007333
26Herpes simplex infection_Homo sapiens_hsa051681.54380697
27Phagosome_Homo sapiens_hsa041451.48643930
28Autoimmune thyroid disease_Homo sapiens_hsa053201.42077616
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41724352
30Shigellosis_Homo sapiens_hsa051311.40798671
31Primary immunodeficiency_Homo sapiens_hsa053401.38627208
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38515416
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.34573593
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28366452
35Type I diabetes mellitus_Homo sapiens_hsa049401.23634897
36Toxoplasmosis_Homo sapiens_hsa051451.23466801
37Vitamin digestion and absorption_Homo sapiens_hsa049771.23346394
38Hematopoietic cell lineage_Homo sapiens_hsa046401.20589121
39Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17124689
40Complement and coagulation cascades_Homo sapiens_hsa046101.11147571
41B cell receptor signaling pathway_Homo sapiens_hsa046621.10838225
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10100920
43TNF signaling pathway_Homo sapiens_hsa046681.08872021
44Vibrio cholerae infection_Homo sapiens_hsa051101.08376546
45Apoptosis_Homo sapiens_hsa042101.08361280
46Jak-STAT signaling pathway_Homo sapiens_hsa046301.08337820
47Chemokine signaling pathway_Homo sapiens_hsa040621.07003704
48African trypanosomiasis_Homo sapiens_hsa051431.04216222
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96347886
50Viral myocarditis_Homo sapiens_hsa054160.94894644
51Pentose phosphate pathway_Homo sapiens_hsa000300.94547057
52Fatty acid elongation_Homo sapiens_hsa000620.93223297
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91669224
54Regulation of autophagy_Homo sapiens_hsa041400.89505040
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.88456876
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84065491
57Arachidonic acid metabolism_Homo sapiens_hsa005900.83034138
58Peroxisome_Homo sapiens_hsa041460.81413708
59Bladder cancer_Homo sapiens_hsa052190.78898883
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78395016
61Epstein-Barr virus infection_Homo sapiens_hsa051690.78335678
62Hepatitis C_Homo sapiens_hsa051600.76297546
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71480816
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68113085
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66782226
66Sulfur metabolism_Homo sapiens_hsa009200.66526213
67Hepatitis B_Homo sapiens_hsa051610.66177066
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63374896
69Fatty acid metabolism_Homo sapiens_hsa012120.61821579
70Renin-angiotensin system_Homo sapiens_hsa046140.61733958
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.61039200
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60487459
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58544195
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57612382
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.56964339
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54860523
77Steroid biosynthesis_Homo sapiens_hsa001000.54158182
78VEGF signaling pathway_Homo sapiens_hsa043700.52202330
79Caffeine metabolism_Homo sapiens_hsa002320.51430352
80Sphingolipid metabolism_Homo sapiens_hsa006000.51371934
81Histidine metabolism_Homo sapiens_hsa003400.51055192
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.49431585
83Glutathione metabolism_Homo sapiens_hsa004800.48622798
84beta-Alanine metabolism_Homo sapiens_hsa004100.46984473
85DNA replication_Homo sapiens_hsa030300.46807867
86Galactose metabolism_Homo sapiens_hsa000520.46096903
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.45739667
88Prolactin signaling pathway_Homo sapiens_hsa049170.44389400
89HIF-1 signaling pathway_Homo sapiens_hsa040660.44137196
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43772021
91Homologous recombination_Homo sapiens_hsa034400.43587642
92Mineral absorption_Homo sapiens_hsa049780.43513438
93PPAR signaling pathway_Homo sapiens_hsa033200.42367001
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41402489
95T cell receptor signaling pathway_Homo sapiens_hsa046600.38900663
96Acute myeloid leukemia_Homo sapiens_hsa052210.38703667
97Fructose and mannose metabolism_Homo sapiens_hsa000510.38564798
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37905347
99Systemic lupus erythematosus_Homo sapiens_hsa053220.37142757
100Synaptic vesicle cycle_Homo sapiens_hsa047210.36606441
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35938307
102Collecting duct acid secretion_Homo sapiens_hsa049660.35373609
103Amoebiasis_Homo sapiens_hsa051460.35366302
104Endocytosis_Homo sapiens_hsa041440.35272351
105Retinol metabolism_Homo sapiens_hsa008300.35119217
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32387977
107Base excision repair_Homo sapiens_hsa034100.32143541
108Folate biosynthesis_Homo sapiens_hsa007900.31564742
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.31128747
110Renal cell carcinoma_Homo sapiens_hsa052110.30563304
111Pyrimidine metabolism_Homo sapiens_hsa002400.29447815
112Notch signaling pathway_Homo sapiens_hsa043300.29349574
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.28344648
114GnRH signaling pathway_Homo sapiens_hsa049120.28319049
115RNA polymerase_Homo sapiens_hsa030200.27967319
116Protein export_Homo sapiens_hsa030600.27948598
117Prion diseases_Homo sapiens_hsa050200.27779292
118Platelet activation_Homo sapiens_hsa046110.27778407
119Pancreatic cancer_Homo sapiens_hsa052120.26597061
120Type II diabetes mellitus_Homo sapiens_hsa049300.25316232
121HTLV-I infection_Homo sapiens_hsa051660.23767734
122Ether lipid metabolism_Homo sapiens_hsa005650.23331356
123Chronic myeloid leukemia_Homo sapiens_hsa052200.22849331
124Viral carcinogenesis_Homo sapiens_hsa052030.18487356
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.17885509

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