GLYCTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the glycerate kinase type-2 family. The encoded enzyme catalyzes the phosphorylation of (R)-glycerate and may be involved in serine degradation and fructose metabolism. Decreased activity of the encoded enzyme may be associated with the disease D-glyceric aciduria. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.96982991
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59807844
3L-phenylalanine catabolic process (GO:0006559)7.59807844
4L-phenylalanine metabolic process (GO:0006558)7.27805042
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27805042
6aromatic amino acid family catabolic process (GO:0009074)6.91550015
7omega-hydroxylase P450 pathway (GO:0097267)6.80915186
8indole-containing compound catabolic process (GO:0042436)6.33698335
9indolalkylamine catabolic process (GO:0046218)6.33698335
10tryptophan catabolic process (GO:0006569)6.33698335
11kynurenine metabolic process (GO:0070189)6.16250817
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.10144460
13glyoxylate metabolic process (GO:0046487)5.98835050
14tryptophan metabolic process (GO:0006568)5.95769066
15bile acid biosynthetic process (GO:0006699)5.90984342
16alpha-linolenic acid metabolic process (GO:0036109)5.60139788
17urea metabolic process (GO:0019627)5.57801975
18urea cycle (GO:0000050)5.57801975
19cysteine metabolic process (GO:0006534)5.57520413
20drug metabolic process (GO:0017144)5.49158215
21negative regulation of fibrinolysis (GO:0051918)5.39080960
22sulfur amino acid catabolic process (GO:0000098)5.31598882
23high-density lipoprotein particle remodeling (GO:0034375)5.29688187
24serine family amino acid catabolic process (GO:0009071)5.28381101
25peptidyl-glutamic acid carboxylation (GO:0017187)5.20522332
26protein carboxylation (GO:0018214)5.20522332
27regulation of fibrinolysis (GO:0051917)5.19454374
28complement activation, alternative pathway (GO:0006957)5.17859820
29regulation of protein activation cascade (GO:2000257)5.17746702
30nitrogen cycle metabolic process (GO:0071941)5.13800218
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.10604549
32lysine metabolic process (GO:0006553)5.04648678
33lysine catabolic process (GO:0006554)5.04648678
34bile acid metabolic process (GO:0008206)5.02751134
35aromatic amino acid family metabolic process (GO:0009072)5.02293195
36homocysteine metabolic process (GO:0050667)4.92194152
37regulation of complement activation (GO:0030449)4.83146651
38ethanol metabolic process (GO:0006067)4.82147424
39amino-acid betaine metabolic process (GO:0006577)4.76417376
40tyrosine metabolic process (GO:0006570)4.73948078
41alpha-amino acid catabolic process (GO:1901606)4.73053327
42regulation of triglyceride catabolic process (GO:0010896)4.67568580
43reverse cholesterol transport (GO:0043691)4.66123417
44regulation of cholesterol esterification (GO:0010872)4.62879243
45regulation of plasminogen activation (GO:0010755)4.60048024
46cellular ketone body metabolic process (GO:0046950)4.56769002
47protein-lipid complex remodeling (GO:0034368)4.55991051
48macromolecular complex remodeling (GO:0034367)4.55991051
49plasma lipoprotein particle remodeling (GO:0034369)4.55991051
50acylglycerol homeostasis (GO:0055090)4.50168200
51triglyceride homeostasis (GO:0070328)4.50168200
52negative regulation of sterol transport (GO:0032372)4.49002873
53negative regulation of cholesterol transport (GO:0032375)4.49002873
54indolalkylamine metabolic process (GO:0006586)4.47728275
55glycine metabolic process (GO:0006544)4.46377074
56acute-phase response (GO:0006953)4.39462691
57glutamate metabolic process (GO:0006536)4.38126447
58cellular biogenic amine catabolic process (GO:0042402)4.37786018
59amine catabolic process (GO:0009310)4.37786018
60serine family amino acid metabolic process (GO:0009069)4.37783613
61coenzyme catabolic process (GO:0009109)4.37288294
62cellular amino acid catabolic process (GO:0009063)4.37225052
63phospholipid efflux (GO:0033700)4.36785130
64bile acid and bile salt transport (GO:0015721)4.29289353
65cellular modified amino acid catabolic process (GO:0042219)4.24773308
66negative regulation of hemostasis (GO:1900047)4.23905994
67negative regulation of blood coagulation (GO:0030195)4.23905994
68imidazole-containing compound metabolic process (GO:0052803)4.23766886
69fat-soluble vitamin biosynthetic process (GO:0042362)4.23106052
70plasma lipoprotein particle clearance (GO:0034381)4.20861276
71oxidative demethylation (GO:0070989)4.19901466
72drug catabolic process (GO:0042737)4.18761729
73benzene-containing compound metabolic process (GO:0042537)4.18622281
74cellular glucuronidation (GO:0052695)4.17996509
75serine family amino acid biosynthetic process (GO:0009070)4.16385830
76plasma lipoprotein particle organization (GO:0071827)4.13341264
77ethanol oxidation (GO:0006069)4.10282704
78phenylpropanoid metabolic process (GO:0009698)4.09960608
79dicarboxylic acid biosynthetic process (GO:0043650)4.09306684
80regulation of humoral immune response (GO:0002920)4.06480217
81protein-lipid complex assembly (GO:0065005)4.06132624
82cholesterol efflux (GO:0033344)4.01717154
83alkaloid metabolic process (GO:0009820)4.01073489
84aldehyde catabolic process (GO:0046185)3.96548272
85arginine metabolic process (GO:0006525)3.96288924
86ketone body metabolic process (GO:1902224)3.95194542
87positive regulation of fatty acid biosynthetic process (GO:0045723)3.93652001
88urate metabolic process (GO:0046415)3.92657196
89protein-lipid complex subunit organization (GO:0071825)3.91789837
90drug transmembrane transport (GO:0006855)3.90505222
91fibrinolysis (GO:0042730)3.87742718
92negative regulation of coagulation (GO:0050819)3.87723377
93short-chain fatty acid metabolic process (GO:0046459)3.86726407
94plasma lipoprotein particle assembly (GO:0034377)3.85304659
95acetyl-CoA metabolic process (GO:0006084)3.83725662
96organic acid catabolic process (GO:0016054)3.82885422
97carboxylic acid catabolic process (GO:0046395)3.82885422
98low-density lipoprotein particle remodeling (GO:0034374)3.80486302
99regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.79817522
100regulation of cholesterol homeostasis (GO:2000188)3.75625040
101glucuronate metabolic process (GO:0019585)3.73744893
102uronic acid metabolic process (GO:0006063)3.73744893
103intestinal cholesterol absorption (GO:0030299)3.72843855
104aspartate family amino acid catabolic process (GO:0009068)3.72097127
105negative regulation of wound healing (GO:0061045)3.71195377
106regulation of bile acid biosynthetic process (GO:0070857)3.71155791
107phospholipid homeostasis (GO:0055091)3.70766993
108cofactor catabolic process (GO:0051187)3.70216857
109positive regulation of triglyceride lipase activity (GO:0061365)3.69440272
110positive regulation of lipoprotein lipase activity (GO:0051006)3.69440272
111blood coagulation, intrinsic pathway (GO:0007597)3.68284317
112exogenous drug catabolic process (GO:0042738)3.68249901
113diacylglycerol metabolic process (GO:0046339)3.67639786
114cholesterol homeostasis (GO:0042632)3.66754556
115complement activation, classical pathway (GO:0006958)3.64415212
116hormone catabolic process (GO:0042447)3.63786956
1172-oxoglutarate metabolic process (GO:0006103)3.63428838
118positive regulation of hemostasis (GO:1900048)3.63406222
119positive regulation of blood coagulation (GO:0030194)3.63406222
120positive regulation of lipid catabolic process (GO:0050996)3.62049364
121sterol homeostasis (GO:0055092)3.61912826
122flavonoid metabolic process (GO:0009812)3.61625316
123lipoprotein metabolic process (GO:0042157)3.60363382
124very-low-density lipoprotein particle assembly (GO:0034379)3.59738156
125complement activation (GO:0006956)3.59337067
126cytolysis (GO:0019835)3.58935484
127protein activation cascade (GO:0072376)3.57249863
128opsonization (GO:0008228)3.52509197
129disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.50161199
130killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.50161199
131negative regulation of lipase activity (GO:0060192)3.48659097
132proline metabolic process (GO:0006560)3.46721598
133intestinal absorption (GO:0050892)3.46153705
134negative regulation of protein activation cascade (GO:2000258)3.45923741
135positive regulation of coagulation (GO:0050820)3.38191349
136S-adenosylmethionine metabolic process (GO:0046500)3.38009989
137fructose metabolic process (GO:0006000)3.31216365
138regulation of apoptotic cell clearance (GO:2000425)3.29041736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.42230347
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.24208963
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.91657087
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.49683957
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.26150966
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00905016
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84866344
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02799758
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.00113749
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.12260310
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10739416
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06419318
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.05751547
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9445425
15FOXA2_19822575_ChIP-Seq_HepG2_Human1.63071859
16CLOCK_20551151_ChIP-Seq_293T_Human1.56216815
17VDR_21846776_ChIP-Seq_THP-1_Human1.52445259
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51660794
19* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45180378
20HTT_18923047_ChIP-ChIP_STHdh_Human1.43173886
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39617260
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38165076
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37929108
24GATA1_22025678_ChIP-Seq_K562_Human1.36278210
25BCOR_27268052_Chip-Seq_Bcells_Human1.33875477
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.33328734
27* BCL6_27268052_Chip-Seq_Bcells_Human1.30890088
28CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27434053
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22801156
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21848205
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21444862
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20498001
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19830052
34SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18506223
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.16810214
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13210955
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.10972063
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.10955462
39VDR_24763502_ChIP-Seq_THP-1_Human1.10848095
40P68_20966046_ChIP-Seq_HELA_Human1.09938573
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09584095
42SMC4_20622854_ChIP-Seq_HELA_Human1.07374174
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06430648
44RACK7_27058665_Chip-Seq_MCF-7_Human1.05834042
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05369135
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04901559
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04895673
48SA1_27219007_Chip-Seq_Bcells_Human1.04632696
49* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02342853
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01313850
51E2F1_20622854_ChIP-Seq_HELA_Human0.98895220
52TCF7_22412390_ChIP-Seq_EML_Mouse0.98300936
53GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98088123
54ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97641953
55IRF8_27001747_Chip-Seq_BMDM_Mouse0.97510592
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97444649
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97018861
58SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96309925
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96015964
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95489426
61PHF8_20622854_ChIP-Seq_HELA_Human0.95268062
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91906897
63RUNX1_22412390_ChIP-Seq_EML_Mouse0.91547799
64MAF_26560356_Chip-Seq_TH1_Human0.91500171
65UTX_26944678_Chip-Seq_JUKART_Human0.90905107
66GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90122629
67MYC_22102868_ChIP-Seq_BL_Human0.89927331
68* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.89864664
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88594605
70SA1_27219007_Chip-Seq_ERYTHROID_Human0.88442638
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87860695
72KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86750432
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86381255
74RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86271231
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85515021
76IRF8_22096565_ChIP-ChIP_GC-B_Human0.85083351
77PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84701591
78GATA4_25053715_ChIP-Seq_YYC3_Human0.84244982
79RAC3_21632823_ChIP-Seq_H3396_Human0.83965720
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.83542934
81P300_27268052_Chip-Seq_Bcells_Human0.83213323
82CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82509921
83CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82508289
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82414367
85STAT4_19710469_ChIP-ChIP_TH1__Mouse0.82386223
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82113930
87AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81614699
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.81315370
89SPI1_20517297_ChIP-Seq_HL60_Human0.80802653
90CTCF_27219007_Chip-Seq_Bcells_Human0.80164361
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79560958
92PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78110457
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77508361
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77113121
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76587210
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.75258848
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71687668
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71079029
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.69720692
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69638775
101* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68163054
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66752012
103ZNF263_19887448_ChIP-Seq_K562_Human0.66495722
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65494580
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64601930
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64585893
107RARB_24833708_ChIP-Seq_LIVER_Mouse0.64118548
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63814318
109LXR_22292898_ChIP-Seq_THP-1_Human0.60836627
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59813575
111CEBPB_22108803_ChIP-Seq_LS180_Human0.59506755
112EGR1_19032775_ChIP-ChIP_M12_Human0.58067488
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56480831
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56480831
115* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54687715
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.54532682
117MYC_19915707_ChIP-ChIP_AK7_Human0.54106543
118AR_20517297_ChIP-Seq_VCAP_Human0.53479077
119FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53026777
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50676396
121ESET_19884257_ChIP-Seq_ESCs_Mouse0.50351378
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50232588
123* FOXA1_25552417_ChIP-Seq_VCAP_Human0.49691527
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.49662563
125STAT1_17558387_ChIP-Seq_HELA_Human0.49307184
126CBP_21632823_ChIP-Seq_H3396_Human0.47961882
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.46957221
128P53_21459846_ChIP-Seq_SAOS-2_Human0.46837180
129PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46786186
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.46568459
131FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.46257466
132PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44615275
133FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42778954
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42619647
135GATA2_19941826_ChIP-Seq_K562_Human0.42589420
136GATA1_19941826_ChIP-Seq_K562_Human0.42497822
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42317635
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42050266
139* TAF2_19829295_ChIP-Seq_ESCs_Human0.41349325
140* GATA6_25053715_ChIP-Seq_YYC3_Human0.41343311
141PPAR_26484153_Chip-Seq_NCI-H1993_Human0.39893206
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.38628127
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38371335
144CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.37923178
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.37528314
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37200692
147TAF15_26573619_Chip-Seq_HEK293_Human0.36356495
148LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36011575
149ERG_21242973_ChIP-ChIP_JURKAT_Human0.35920860
150EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35754309
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.35743406
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.35683682
153ESR1_20079471_ChIP-ChIP_T-47D_Human0.35462215
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.35242539
155BCAT_22108803_ChIP-Seq_LS180_Human0.35239400
156P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.34856607
157SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.34670914

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.30340588
2MP0005360_urolithiasis7.73696604
3MP0005085_abnormal_gallbladder_physiolo6.31496454
4MP0005365_abnormal_bile_salt6.08463993
5MP0008875_abnormal_xenobiotic_pharmacok5.05296121
6MP0003806_abnormal_nucleotide_metabolis4.14922939
7MP0003252_abnormal_bile_duct3.94024183
8MP0010329_abnormal_lipoprotein_level3.49196310
9MP0009840_abnormal_foam_cell3.13020194
10MP0005083_abnormal_biliary_tract3.01322664
11MP0005332_abnormal_amino_acid2.98332472
12MP0003195_calcinosis2.94188719
13MP0001666_abnormal_nutrient_absorption2.56552711
14MP0004019_abnormal_vitamin_homeostasis2.39093016
15MP0003191_abnormal_cellular_cholesterol2.28763657
16MP0002138_abnormal_hepatobiliary_system2.19675066
17MP0000609_abnormal_liver_physiology2.13731937
18MP0002118_abnormal_lipid_homeostasis2.07406546
19MP0005319_abnormal_enzyme/_coenzyme1.84150626
20MP0003868_abnormal_feces_composition1.83213749
21MP0001764_abnormal_homeostasis1.66739234
22MP0005584_abnormal_enzyme/coenzyme_acti1.60844565
23MP0005451_abnormal_body_composition1.46867047
24MP0009643_abnormal_urine_homeostasis1.45107718
25MP0009697_abnormal_copulation1.43173328
26MP0010155_abnormal_intestine_physiology1.38881131
27MP0003183_abnormal_peptide_metabolism1.34383734
28MP0003186_abnormal_redox_activity1.31906970
29MP0003011_delayed_dark_adaptation1.31778956
30MP0002132_abnormal_respiratory_system1.31425551
31MP0009785_altered_susceptibility_to1.29033109
32MP0003656_abnormal_erythrocyte_physiolo1.20953958
33MP0000598_abnormal_liver_morphology1.17621173
34MP0005647_abnormal_sex_gland1.11439156
35MP0005636_abnormal_mineral_homeostasis1.11278970
36MP0003705_abnormal_hypodermis_morpholog1.09585353
37MP0003303_peritoneal_inflammation1.07387318
38MP0009764_decreased_sensitivity_to1.05706213
39MP0000604_amyloidosis1.04022352
40MP0005025_abnormal_response_to1.00950366
41MP0002254_reproductive_system_inflammat0.98616568
42MP0009763_increased_sensitivity_to0.97338177
43MP0003172_abnormal_lysosome_physiology0.90839419
44MP0002419_abnormal_innate_immunity0.90781628
45MP0008469_abnormal_protein_level0.89441052
46MP0009642_abnormal_blood_homeostasis0.88678219
47MP0005084_abnormal_gallbladder_morpholo0.88525512
48MP0005670_abnormal_white_adipose0.88332551
49MP0006036_abnormal_mitochondrial_physio0.88055784
50MP0010368_abnormal_lymphatic_system0.84741464
51MP0003879_abnormal_hair_cell0.83835743
52MP0002876_abnormal_thyroid_physiology0.83270097
53MP0008260_abnormal_autophagy0.81646181
54MP0009333_abnormal_splenocyte_physiolog0.81321172
55MP0005408_hypopigmentation0.80863129
56MP0002078_abnormal_glucose_homeostasis0.77861737
57MP0001756_abnormal_urination0.77359272
58MP0005376_homeostasis/metabolism_phenot0.76313883
59MP0009765_abnormal_xenobiotic_induced0.76294346
60MP0005220_abnormal_exocrine_pancreas0.75695337
61MP0003866_abnormal_defecation0.73030592
62MP0005387_immune_system_phenotype0.71998085
63MP0001790_abnormal_immune_system0.71998085
64MP0001800_abnormal_humoral_immune0.71459936
65MP0002971_abnormal_brown_adipose0.71197274
66MP0005535_abnormal_body_temperature0.71181192
67MP0001661_extended_life_span0.70659759
68MP0001835_abnormal_antigen_presentation0.70101278
69MP0005000_abnormal_immune_tolerance0.70026735
70MP0000685_abnormal_immune_system0.70007812
71MP0005334_abnormal_fat_pad0.66926337
72MP0001533_abnormal_skeleton_physiology0.66326718
73MP0004130_abnormal_muscle_cell0.66217422
74MP0000858_altered_metastatic_potential0.65854468
75MP0003300_gastrointestinal_ulcer0.64244313
76MP0002136_abnormal_kidney_physiology0.63960650
77MP0003329_amyloid_beta_deposits0.62585785
78MP0003690_abnormal_glial_cell0.62192913
79MP0006035_abnormal_mitochondrial_morpho0.61754208
80MP0005266_abnormal_metabolism0.60948007
81MP0001663_abnormal_digestive_system0.59545454
82MP0002928_abnormal_bile_duct0.58791705
83MP0009053_abnormal_anal_canal0.58706545
84MP0001915_intracranial_hemorrhage0.57787454
85MP0002723_abnormal_immune_serum0.57441741
86MP0005671_abnormal_response_to0.55207372
87MP0004043_abnormal_pH_regulation0.53950737
88MP0000639_abnormal_adrenal_gland0.52287667
89MP0005448_abnormal_energy_balance0.51340693
90MP0005395_other_phenotype0.51095664
91MP0005464_abnormal_platelet_physiology0.49794733
92MP0005409_darkened_coat_color0.49349167
93MP0003638_abnormal_response/metabolism_0.49174248
94MP0000477_abnormal_intestine_morphology0.47509567
95MP0001545_abnormal_hematopoietic_system0.46047974
96MP0005397_hematopoietic_system_phenotyp0.46047974
97MP0002089_abnormal_postnatal_growth/wei0.45980554
98MP0004947_skin_inflammation0.44904923
99MP0002452_abnormal_antigen_presenting0.44620093
100MP0002249_abnormal_larynx_morphology0.44576817
101MP0000465_gastrointestinal_hemorrhage0.44571015
102MP0005666_abnormal_adipose_tissue0.44547343
103MP0002822_catalepsy0.44333489
104MP0003718_maternal_effect0.44321999
105MP0005164_abnormal_response_to0.43164614
106MP0008874_decreased_physiological_sensi0.43099775
107MP0003724_increased_susceptibility_to0.42388634
108MP0003953_abnormal_hormone_level0.41845296
109MP0008873_increased_physiological_sensi0.41571992
110MP0001765_abnormal_ion_homeostasis0.39975281
111MP0003436_decreased_susceptibility_to0.39867992
112MP0004782_abnormal_surfactant_physiolog0.39479862
113MP0003075_altered_response_to0.37896547
114MP0005166_decreased_susceptibility_to0.37289780
115MP0002168_other_aberrant_phenotype0.37105018
116MP0009672_abnormal_birth_weight0.36687272
117MP0000230_abnormal_systemic_arterial0.35824556
118MP0008872_abnormal_physiological_respon0.35655672
119MP0002837_dystrophic_cardiac_calcinosis0.34169219
120MP0005058_abnormal_lysosome_morphology0.33988741
121MP0004381_abnormal_hair_follicle0.33624723
122MP0005248_abnormal_Harderian_gland0.33206296
123MP0002796_impaired_skin_barrier0.33076926
124MP0009115_abnormal_fat_cell0.32758576
125MP0006082_CNS_inflammation0.30882831
126MP0009384_cardiac_valve_regurgitation0.30587629
127MP0002970_abnormal_white_adipose0.30509541
128MP0001853_heart_inflammation0.30203310
129MP0000579_abnormal_nail_morphology0.29900867
130MP0001845_abnormal_inflammatory_respons0.29661956
131MP0002135_abnormal_kidney_morphology0.28471139
132MP0000249_abnormal_blood_vessel0.27803877
133MP0004264_abnormal_extraembryonic_tissu0.26810493
134MP0001243_abnormal_dermal_layer0.26004785
135MP0004883_abnormal_blood_vessel0.24783229

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.29233240
2Intrahepatic cholestasis (HP:0001406)7.15422201
3Deep venous thrombosis (HP:0002625)7.11798752
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51276107
5Prolonged partial thromboplastin time (HP:0003645)6.26436906
6Xanthomatosis (HP:0000991)6.21209640
7Hypobetalipoproteinemia (HP:0003563)6.15722371
8Hyperlipoproteinemia (HP:0010980)5.33141450
9Complement deficiency (HP:0004431)5.20435807
10Hyperammonemia (HP:0001987)4.69948439
11Joint hemorrhage (HP:0005261)4.65957437
12Hypolipoproteinemia (HP:0010981)4.60273837
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.48331068
14Ketosis (HP:0001946)4.46476337
15Epidermoid cyst (HP:0200040)4.38639094
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.32190482
17Hyperglycinuria (HP:0003108)4.30983971
18Abnormality of the common coagulation pathway (HP:0010990)4.29464449
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.24714998
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.20479358
21Abnormality of methionine metabolism (HP:0010901)4.12065416
22Fat malabsorption (HP:0002630)4.04420118
23Hypoalphalipoproteinemia (HP:0003233)4.02223867
24Hypoglycemic coma (HP:0001325)3.87126239
25Abnormality of pyrimidine metabolism (HP:0004353)3.80304747
26Abnormality of complement system (HP:0005339)3.77486493
27* Abnormality of glycine metabolism (HP:0010895)3.75574216
28* Abnormality of serine family amino acid metabolism (HP:0010894)3.75574216
29* Hyperglycinemia (HP:0002154)3.71186074
30Conjugated hyperbilirubinemia (HP:0002908)3.67817331
31Abnormality of the intrinsic pathway (HP:0010989)3.61151865
32Abnormality of fatty-acid metabolism (HP:0004359)3.54000078
33Nephritis (HP:0000123)3.50698484
34Hypercholesterolemia (HP:0003124)3.50511644
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.36913535
36Abnormality of nucleobase metabolism (HP:0010932)3.30910606
37Ketoacidosis (HP:0001993)3.29806789
38Hyperbilirubinemia (HP:0002904)3.29736345
39Delayed CNS myelination (HP:0002188)3.23106327
40Gout (HP:0001997)3.10664433
41Purpura (HP:0000979)3.10305949
42Abnormality of purine metabolism (HP:0004352)3.06213535
43Hepatocellular carcinoma (HP:0001402)3.02521379
44Steatorrhea (HP:0002570)3.00643781
45Spontaneous abortion (HP:0005268)2.93019751
46Myocardial infarction (HP:0001658)2.86997513
47Hypochromic microcytic anemia (HP:0004840)2.82973115
48* Abnormality of serum amino acid levels (HP:0003112)2.80837985
49* Metabolic acidosis (HP:0001942)2.75103819
50Vascular calcification (HP:0004934)2.73150054
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72974128
52Dicarboxylic aciduria (HP:0003215)2.72974128
53Lethargy (HP:0001254)2.69488754
54Skin nodule (HP:0200036)2.67988630
55Systemic lupus erythematosus (HP:0002725)2.66404749
56Spastic diplegia (HP:0001264)2.52628563
57Acanthocytosis (HP:0001927)2.50565775
58Hypoglycemic seizures (HP:0002173)2.46708914
59Irritability (HP:0000737)2.42709973
60Malnutrition (HP:0004395)2.42692386
61Cerebral edema (HP:0002181)2.42469588
62Cardiovascular calcification (HP:0011915)2.41258426
63Neonatal onset (HP:0003623)2.40638024
64Generalized aminoaciduria (HP:0002909)2.39942282
65Pulmonary embolism (HP:0002204)2.39467026
66Mitral stenosis (HP:0001718)2.39034895
67Abnormal gallbladder morphology (HP:0012437)2.38319385
68Abnormal gallbladder physiology (HP:0012438)2.36314173
69Cholecystitis (HP:0001082)2.36314173
70Cholelithiasis (HP:0001081)2.34350768
71Glomerulonephritis (HP:0000099)2.31813562
72Recurrent gram-negative bacterial infections (HP:0005420)2.26664480
73Enlarged kidneys (HP:0000105)2.26450665
74Late onset (HP:0003584)2.25286214
75Alkalosis (HP:0001948)2.23069692
76Sensorimotor neuropathy (HP:0007141)2.23024053
77Vomiting (HP:0002013)2.22182923
78Abnormality of the Achilles tendon (HP:0005109)2.21217499
79Proximal tubulopathy (HP:0000114)2.18992153
80Pancreatitis (HP:0001733)2.18591671
81Esophageal varix (HP:0002040)2.16635198
82Elevated alkaline phosphatase (HP:0003155)2.16406753
83Increased purine levels (HP:0004368)2.15050104
84Hyperuricemia (HP:0002149)2.15050104
85Brushfield spots (HP:0001088)2.14894588
86Epistaxis (HP:0000421)2.14546735
87Amyloidosis (HP:0011034)2.13798152
88Increased serum ferritin (HP:0003281)2.13584629
89Abnormality of alkaline phosphatase activity (HP:0004379)2.13016963
90Rickets (HP:0002748)2.10847887
91Gingival bleeding (HP:0000225)2.10582457
92Widely patent fontanelles and sutures (HP:0004492)2.09514801
93Abnormality of proline metabolism (HP:0010907)2.09078751
94Hydroxyprolinuria (HP:0003080)2.09078751
95Eczematoid dermatitis (HP:0000976)2.07412921
96Menorrhagia (HP:0000132)2.07339912
97Thrombophlebitis (HP:0004418)2.07134195
98Hypophosphatemia (HP:0002148)2.02700689
99Joint swelling (HP:0001386)2.01853201
100Hyperinsulinemic hypoglycemia (HP:0000825)1.99947886
101Abnormality of the gallbladder (HP:0005264)1.97186128
102Hemorrhage of the eye (HP:0011885)1.97103936
103Abnormal enzyme/coenzyme activity (HP:0012379)1.96596180
104Hypertriglyceridemia (HP:0002155)1.95195640
105Abnormality of vitamin metabolism (HP:0100508)1.95173164
106Poikilocytosis (HP:0004447)1.94760380
107Glycosuria (HP:0003076)1.93173117
108Abnormality of urine glucose concentration (HP:0011016)1.93173117
109Hypophosphatemic rickets (HP:0004912)1.92353823
110Gangrene (HP:0100758)1.91023733
111Orchitis (HP:0100796)1.90886923
112Abnormal cartilage morphology (HP:0002763)1.90502489
113Abnormality of transition element cation homeostasis (HP:0011030)1.85849826
114Renal cortical cysts (HP:0000803)1.85724676
115Osteomalacia (HP:0002749)1.84974449
116Abnormality of iron homeostasis (HP:0011031)1.84213720
117Elevated hepatic transaminases (HP:0002910)1.83741554
118Hyperphosphaturia (HP:0003109)1.82966376
119Myositis (HP:0100614)1.82678544
120Cerebral palsy (HP:0100021)1.82017131
121Abnormal platelet function (HP:0011869)1.73725027
122Impaired platelet aggregation (HP:0003540)1.73725027
123Abnormal platelet volume (HP:0011876)1.73288534
124Gingivitis (HP:0000230)1.72005458
125Nephrolithiasis (HP:0000787)1.70204226
126Abnormal urine phosphate concentration (HP:0012599)1.69476506
127Increased mean platelet volume (HP:0011877)1.68913793
128Abnormal tarsal ossification (HP:0008369)1.68578700
129Retrobulbar optic neuritis (HP:0100654)1.66580270
130Optic neuritis (HP:0100653)1.66580270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.21577774
2FGFR44.63878778
3SIK14.43393511
4ERN14.38297776
5TAOK32.90221702
6ERBB42.86336235
7INSRR2.84500889
8PRPF4B2.35819932
9MAP2K42.18391254
10RIPK42.15677019
11PKN22.13020873
12MST1R2.07095247
13MAPK111.96991038
14TRIB31.86283699
15FLT31.79082302
16BLK1.65983990
17PIK3CG1.62795593
18TYK21.61624051
19ACVR1B1.60082412
20LATS11.56883444
21TESK21.55141836
22PTK61.48496847
23DAPK21.39329088
24ABL21.37757567
25ZAP701.36992954
26FRK1.30862474
27MAP3K71.30732598
28GRK61.30295950
29FGFR21.29732940
30NEK91.26941751
31PINK11.25774751
32STK38L1.23317752
33JAK21.21140484
34KDR1.20046192
35IRAK41.16970216
36MAP3K101.15635580
37PRKG21.12661167
38PRKAA21.12153034
39TAOK11.10578427
40WNK31.08521212
41CDC42BPA1.06890255
42MAP2K31.00950117
43WNK40.99439734
44TBK10.98880705
45ERBB20.97495468
46MAP3K140.97236560
47MATK0.96828824
48JAK10.95836461
49JAK30.95399977
50SMG10.94692453
51MAPK40.94092730
52KSR20.93735354
53EPHB10.91169873
54TNK20.91155159
55PRKCZ0.90492412
56EPHA20.86522295
57FGR0.85548447
58DYRK1B0.84664979
59MAP3K30.80722229
60SGK30.80117341
61CDK60.78446473
62FES0.76766238
63MET0.76403873
64DDR20.76166044
65LCK0.75628673
66MAPK120.75097370
67BTK0.75001608
68MAP3K110.74759334
69GSK3A0.74486188
70TIE10.74099435
71PDK30.73653314
72PDK40.73653314
73MAPK150.73528438
74SYK0.73355136
75PRKACG0.72839297
76PRKAA10.71514174
77TXK0.71435318
78EPHA30.69161102
79LYN0.68477556
80CSK0.68215445
81OXSR10.67480126
82RIPK10.67057108
83PIK3CA0.66340423
84IRAK30.64759611
85FGFR30.64255314
86MAP2K60.63910606
87SGK20.63632263
88SGK2230.61999068
89SGK4940.61999068
90HCK0.61609327
91MAP2K20.60771878
92PTK20.59310459
93CAMK2G0.58699520
94TGFBR20.57468271
95NLK0.57249324
96PDGFRA0.57020923
97MAP3K20.56898878
98CSF1R0.55901995
99PDPK10.55425843
100CAMK1D0.55180386
101SIK30.55134748
102LMTK20.54961127
103MAPK70.52573820
104PRKCQ0.51312264
105TESK10.50650350
106CAMKK20.49002944
107PRKD20.48753232
108IKBKE0.48697140
109PIM20.47485531
110CSNK1G10.45254745
111ICK0.45093186
112SIK20.45059016
113CDK40.44904826
114IKBKB0.43643342
115ITK0.42947465
116FER0.42656870
117TAOK20.42444250
118NME20.42351312
119EPHA40.41151622
120SRC0.40538817
121IGF1R0.40112483
122MAP3K50.39609422
123FYN0.38923935
124MTOR0.38910483
125BMX0.38385479
126PDK10.37938034
127IRAK10.37681086
128MAP3K130.37648076
129PAK40.35905850
130GRK10.35072321
131PRKCG0.32364680
132RET0.32348736
133EGFR0.31901420
134MAP2K10.31813401
135PKN10.31342505
136IRAK20.29573707
137CAMK40.27851221
138STK30.27589524
139MAP3K60.26896292
140PDK20.24165409
141MAP3K10.23765594
142PRKCA0.23620382
143MAP4K10.23525530
144STK380.22998380
145PAK30.20804074

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.40929164
2Nitrogen metabolism_Homo sapiens_hsa009103.52172016
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37770067
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.36908949
5Arginine biosynthesis_Homo sapiens_hsa002203.01223548
6Tryptophan metabolism_Homo sapiens_hsa003802.72740727
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68978849
8Complement and coagulation cascades_Homo sapiens_hsa046102.64427446
9* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57328518
10Fatty acid degradation_Homo sapiens_hsa000712.55545782
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48893602
12* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45842806
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30349215
14Butanoate metabolism_Homo sapiens_hsa006502.29893213
15Peroxisome_Homo sapiens_hsa041462.15628030
16Propanoate metabolism_Homo sapiens_hsa006402.05738871
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05356060
18PPAR signaling pathway_Homo sapiens_hsa033201.88490564
19Histidine metabolism_Homo sapiens_hsa003401.88162312
20Fatty acid metabolism_Homo sapiens_hsa012121.85835403
21Chemical carcinogenesis_Homo sapiens_hsa052041.85588556
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.85061035
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82499954
24beta-Alanine metabolism_Homo sapiens_hsa004101.76991301
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76577412
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72311337
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.71641392
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66207461
29Staphylococcus aureus infection_Homo sapiens_hsa051501.65819798
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64712438
31Retinol metabolism_Homo sapiens_hsa008301.63243509
32Selenocompound metabolism_Homo sapiens_hsa004501.62056581
33Caffeine metabolism_Homo sapiens_hsa002321.59689034
34Phenylalanine metabolism_Homo sapiens_hsa003601.54119992
35Bile secretion_Homo sapiens_hsa049761.52312713
36Pyruvate metabolism_Homo sapiens_hsa006201.47772847
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40547902
38Tyrosine metabolism_Homo sapiens_hsa003501.38882481
39Sulfur metabolism_Homo sapiens_hsa009201.36049010
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32197875
41Fatty acid elongation_Homo sapiens_hsa000621.30792370
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27865858
43Biosynthesis of amino acids_Homo sapiens_hsa012301.23491554
44Folate biosynthesis_Homo sapiens_hsa007901.21742622
45Carbon metabolism_Homo sapiens_hsa012001.19948231
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.19855060
47ABC transporters_Homo sapiens_hsa020101.17921984
48Steroid biosynthesis_Homo sapiens_hsa001001.13415146
49Fat digestion and absorption_Homo sapiens_hsa049751.11711977
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09473738
51Other glycan degradation_Homo sapiens_hsa005111.04737710
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.03250291
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01907723
54Arginine and proline metabolism_Homo sapiens_hsa003301.00755539
55Vitamin digestion and absorption_Homo sapiens_hsa049770.97576180
56Sulfur relay system_Homo sapiens_hsa041220.96032472
57Vitamin B6 metabolism_Homo sapiens_hsa007500.95045571
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93786646
59Lysine degradation_Homo sapiens_hsa003100.88642447
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86898668
61One carbon pool by folate_Homo sapiens_hsa006700.76528743
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76261070
63Glutathione metabolism_Homo sapiens_hsa004800.70998089
64Pertussis_Homo sapiens_hsa051330.68240467
65Pentose phosphate pathway_Homo sapiens_hsa000300.61832568
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61623460
67* Glycerolipid metabolism_Homo sapiens_hsa005610.59531183
68Fatty acid biosynthesis_Homo sapiens_hsa000610.50800745
69* Metabolic pathways_Homo sapiens_hsa011000.46805789
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36605598
71Prion diseases_Homo sapiens_hsa050200.30796019
72Fructose and mannose metabolism_Homo sapiens_hsa000510.29753382
73Galactose metabolism_Homo sapiens_hsa000520.25463839
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25010619
75Insulin resistance_Homo sapiens_hsa049310.24141754
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.22735782
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18647001
78Linoleic acid metabolism_Homo sapiens_hsa005910.16369376
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.14900171
80Leishmaniasis_Homo sapiens_hsa051400.14455900
81Glucagon signaling pathway_Homo sapiens_hsa049220.11031964
82Graft-versus-host disease_Homo sapiens_hsa053320.10936839
83Allograft rejection_Homo sapiens_hsa053300.08223869
84Sphingolipid metabolism_Homo sapiens_hsa006000.07659272
85Autoimmune thyroid disease_Homo sapiens_hsa053200.05558625
86Amoebiasis_Homo sapiens_hsa051460.03527039
87AMPK signaling pathway_Homo sapiens_hsa041520.03096034
88Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2374261
89Mineral absorption_Homo sapiens_hsa04978-0.2358697
90Bladder cancer_Homo sapiens_hsa05219-0.2356414
91Protein digestion and absorption_Homo sapiens_hsa04974-0.2336950
92Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1982987
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1833284
94African trypanosomiasis_Homo sapiens_hsa05143-0.1794454
95Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1680888
96Hepatitis C_Homo sapiens_hsa05160-0.1632555
97Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1595049
98Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1540431
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1528168
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1503484
101Regulation of autophagy_Homo sapiens_hsa04140-0.1457708
102Renin-angiotensin system_Homo sapiens_hsa04614-0.1426127
103Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1117291
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1058260
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1050385
106Insulin signaling pathway_Homo sapiens_hsa04910-0.1035123
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0920463
108Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.0607985
109Tuberculosis_Homo sapiens_hsa05152-0.0531916
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0506931
111Lysosome_Homo sapiens_hsa04142-0.0409883
112NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0254460
113Osteoclast differentiation_Homo sapiens_hsa04380-0.0150266

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