GLYCAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pattern specification involved in kidney development (GO:0061004)8.48908493
2fatty-acyl-CoA biosynthetic process (GO:0046949)8.07800035
3long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)7.93562206
4acyl-CoA biosynthetic process (GO:0071616)7.84337659
5thioester biosynthetic process (GO:0035384)7.84337659
6alpha-linolenic acid metabolic process (GO:0036109)7.78779068
7pyrimidine-containing compound transmembrane transport (GO:0072531)7.58529877
8regulation of vascular endothelial growth factor signaling pathway (GO:1900746)7.38146021
9lactation (GO:0007595)7.00204021
10regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)6.89205726
11linoleic acid metabolic process (GO:0043651)6.67549110
12regulation of sequestering of triglyceride (GO:0010889)6.64193834
13mammary gland epithelial cell differentiation (GO:0060644)6.27919911
14positive regulation of p38MAPK cascade (GO:1900745)6.13516109
15fatty acid transmembrane transport (GO:1902001)6.13417928
16carnitine shuttle (GO:0006853)6.09644736
17long-chain fatty-acyl-CoA metabolic process (GO:0035336)6.06440694
18ectoderm development (GO:0007398)5.97392954
19fatty-acyl-CoA metabolic process (GO:0035337)5.78650590
20secretion by tissue (GO:0032941)5.72149341
21biotin metabolic process (GO:0006768)5.71432809
22nucleoside transmembrane transport (GO:1901642)5.53875140
23tooth mineralization (GO:0034505)5.06266103
24acetyl-CoA metabolic process (GO:0006084)5.04380872
25nucleobase catabolic process (GO:0046113)4.93194933
26N-acetylneuraminate metabolic process (GO:0006054)4.90209070
27body fluid secretion (GO:0007589)4.78805283
28triglyceride biosynthetic process (GO:0019432)4.69885923
29embryonic process involved in female pregnancy (GO:0060136)4.60818984
30O-glycan processing (GO:0016266)4.55074697
31carnitine transmembrane transport (GO:1902603)4.51815439
32neutral lipid biosynthetic process (GO:0046460)4.51667913
33acylglycerol biosynthetic process (GO:0046463)4.51667913
34coenzyme A biosynthetic process (GO:0015937)4.43538006
35segment specification (GO:0007379)4.43390033
36folic acid transport (GO:0015884)4.41593615
37regulation of p38MAPK cascade (GO:1900744)4.34133875
38regulation of apoptotic process involved in morphogenesis (GO:1902337)4.31386449
39response to phenylpropanoid (GO:0080184)4.30776676
40Golgi transport vesicle coating (GO:0048200)4.22079761
41COPI coating of Golgi vesicle (GO:0048205)4.22079761
42regulation of penile erection (GO:0060405)4.18630772
43nucleoside transport (GO:0015858)4.16424676
44carnitine transport (GO:0015879)4.13433860
45amino-acid betaine transport (GO:0015838)4.13433860
46long-chain fatty acid transport (GO:0015909)4.11464733
47positive regulation of macrophage cytokine production (GO:0060907)3.94632418
48lipid storage (GO:0019915)3.93790088
49regulation of triglyceride biosynthetic process (GO:0010866)3.89096464
50copper ion transport (GO:0006825)3.86917658
51low-density lipoprotein particle clearance (GO:0034383)3.82922966
52phagocytosis, recognition (GO:0006910)3.82057223
53regulation of triglyceride metabolic process (GO:0090207)3.80499627
54fatty acid transport (GO:0015908)3.70485864
55positive regulation of triglyceride metabolic process (GO:0090208)3.66593462
56growth hormone receptor signaling pathway (GO:0060396)3.64911196
57heme transport (GO:0015886)3.62674204
58intracellular lipid transport (GO:0032365)3.62085058
59oligosaccharide metabolic process (GO:0009311)3.61766464
60pentose-phosphate shunt (GO:0006098)3.58945394
61thioester metabolic process (GO:0035383)3.58298188
62acyl-CoA metabolic process (GO:0006637)3.58298188
63zinc ion transport (GO:0006829)3.55100993
64positive regulation of lipid storage (GO:0010884)3.54404366
65valine metabolic process (GO:0006573)3.51254475
66positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.49798224
67negative regulation of execution phase of apoptosis (GO:1900118)3.47697596
68negative regulation of fatty acid transport (GO:2000192)3.45904229
69coenzyme A metabolic process (GO:0015936)3.39207286
70regulation of macrophage cytokine production (GO:0010935)3.37056229
71regulation of vasculogenesis (GO:2001212)3.32925973
72regulation of triglyceride catabolic process (GO:0010896)3.30131017
73triglyceride metabolic process (GO:0006641)3.28398872
74purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.28086076
75ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.28086076
76nucleoside bisphosphate biosynthetic process (GO:0033866)3.28086076
77triglyceride catabolic process (GO:0019433)3.26597549
78regulation of endothelial cell differentiation (GO:0045601)3.26594393
79transcytosis (GO:0045056)3.25415747
80urate metabolic process (GO:0046415)3.24306511
81angiogenesis involved in wound healing (GO:0060055)3.23102902
82NADPH regeneration (GO:0006740)3.19446369
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.10381124
84iron coordination entity transport (GO:1901678)3.09802627
85acylglycerol metabolic process (GO:0006639)3.09684410
86cellular response to growth hormone stimulus (GO:0071378)3.06917076
87neutral lipid metabolic process (GO:0006638)3.05688856
88sialylation (GO:0097503)3.04100998
89neutral lipid catabolic process (GO:0046461)3.01104497
90acylglycerol catabolic process (GO:0046464)3.01104497
91positive regulation of tissue remodeling (GO:0034105)2.99695131
92galactose metabolic process (GO:0006012)2.97108182
93positive regulation of histone deacetylation (GO:0031065)2.95001694
94positive regulation of lipoprotein lipase activity (GO:0051006)2.92995194
95positive regulation of triglyceride lipase activity (GO:0061365)2.92995194
96localization within membrane (GO:0051668)2.92203394
97cellular carbohydrate biosynthetic process (GO:0034637)2.91655449
98quaternary ammonium group transport (GO:0015697)2.91463979
99positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.91050776
100oligosaccharide biosynthetic process (GO:0009312)11.9195594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse7.35853555
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.21561780
3ESR1_21235772_ChIP-Seq_MCF-7_Human4.90724942
4ESR2_21235772_ChIP-Seq_MCF-7_Human3.95693905
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.80074837
6CLOCK_20551151_ChIP-Seq_293T_Human3.44702752
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.30672783
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.28958081
9ZNF263_19887448_ChIP-Seq_K562_Human2.82141526
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.64008307
11AR_21572438_ChIP-Seq_LNCaP_Human2.56072385
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.55773026
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.54725154
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52889610
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.52241001
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36333622
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.28845566
18ESR1_15608294_ChIP-ChIP_MCF-7_Human2.09167835
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07997035
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.99323015
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96558302
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92961246
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89305711
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.82012513
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78098172
26RXR_22108803_ChIP-Seq_LS180_Human1.77232622
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.76989440
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69824645
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.65613217
30SOX2_20726797_ChIP-Seq_SW620_Human1.58455152
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.53974644
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52182141
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.44298104
34ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.43760465
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40873718
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.36790862
37GATA4_25053715_ChIP-Seq_YYC3_Human1.33978286
38RACK7_27058665_Chip-Seq_MCF-7_Human1.29876297
39KLF5_25053715_ChIP-Seq_YYC3_Human1.28735018
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26364119
41RUNX1_27514584_Chip-Seq_MCF-7_Human1.26357830
42SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.25312686
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.24751963
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18734171
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17242442
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.14726139
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.14726139
48GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11589454
49GATA3_24758297_ChIP-Seq_MCF-7_Human1.11098170
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10473584
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09414196
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08396470
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08300016
54CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04783016
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03617017
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02847722
57P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98197464
58MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97792693
59GATA1_19941826_ChIP-Seq_K562_Human0.96761821
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95218942
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94814899
62ATF3_27146783_Chip-Seq_COLON_Human0.91997598
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91456750
64LXR_22292898_ChIP-Seq_THP-1_Human0.91070351
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89549258
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.89227529
67FOXA1_25552417_ChIP-Seq_VCAP_Human0.88500518
68TP63_23658742_ChIP-Seq_EP156T_Human0.88239203
69HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88029292
70PIAS1_25552417_ChIP-Seq_VCAP_Human0.87356557
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86583683
72TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85870871
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85796575
74CHD1_26751641_Chip-Seq_LNCaP_Human0.85730827
75ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84787856
76ELK3_25401928_ChIP-Seq_HUVEC_Human0.83888495
77CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83404455
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82628001
79EGR1_19374776_ChIP-ChIP_THP-1_Human0.82428509
80ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82000717
81CREB1_26743006_Chip-Seq_LNCaP_Human0.80522954
82GATA2_19941826_ChIP-Seq_K562_Human0.80319574
83PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80314367
84TP53_18474530_ChIP-ChIP_U2OS_Human0.79991573
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79913125
86NANOG_21062744_ChIP-ChIP_HESCs_Human0.79741791
87CJUN_26792858_Chip-Seq_BT549_Human0.79200332
88NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78909593
89CBP_21632823_ChIP-Seq_H3396_Human0.77970350
90ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77887499
91KDM2B_26808549_Chip-Seq_K562_Human0.77855005
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77782222
93GATA2_21666600_ChIP-Seq_HMVEC_Human0.77334178
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77084844
95AR_25329375_ChIP-Seq_VCAP_Human0.76215625
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76086764
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76086539
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75523772
99TCF4_22108803_ChIP-Seq_LS180_Human0.75056426
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.73749004

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.60777443
2MP0003136_yellow_coat_color3.59145571
3MP0000627_abnormal_mammary_gland3.55601985
4MP0005083_abnormal_biliary_tract3.37311194
5MP0003303_peritoneal_inflammation3.19830683
6MP0003300_gastrointestinal_ulcer3.01347197
7MP0004130_abnormal_muscle_cell2.90041645
8MP0002254_reproductive_system_inflammat2.84595256
9MP0001873_stomach_inflammation2.65387150
10MP0004147_increased_porphyrin_level2.54759866
11MP0003705_abnormal_hypodermis_morpholog2.49869983
12MP0004019_abnormal_vitamin_homeostasis2.41931766
13MP0003011_delayed_dark_adaptation2.38993474
14MP0005360_urolithiasis2.22698996
15MP0003718_maternal_effect2.15890766
16MP0001881_abnormal_mammary_gland12.7596376
17MP0005085_abnormal_gallbladder_physiolo1.94459577
18MP0002796_impaired_skin_barrier1.90788367
19MP0004264_abnormal_extraembryonic_tissu1.81185736
20MP0005666_abnormal_adipose_tissue1.55559639
21MP0001666_abnormal_nutrient_absorption1.45411459
22MP0005395_other_phenotype1.43368870
23MP0002118_abnormal_lipid_homeostasis1.41350498
24MP0005670_abnormal_white_adipose1.38061229
25MP0008438_abnormal_cutaneous_collagen1.35685967
26MP0002139_abnormal_hepatobiliary_system1.34336954
27MP0010329_abnormal_lipoprotein_level1.33811961
28MP0002098_abnormal_vibrissa_morphology1.30950561
29MP0001664_abnormal_digestion1.30107685
30MP0004185_abnormal_adipocyte_glucose1.23725361
31MP0004272_abnormal_basement_membrane1.23084421
32MP0005375_adipose_tissue_phenotype1.15276570
33MP0002009_preneoplasia1.11556727
34MP0000377_abnormal_hair_follicle1.04204945
35MP0005501_abnormal_skin_physiology0.97635345
36MP0005584_abnormal_enzyme/coenzyme_acti0.97115632
37MP0001663_abnormal_digestive_system0.93466966
38MP0010352_gastrointestinal_tract_polyps0.92008086
39MP0010678_abnormal_skin_adnexa0.91692426
40MP0003566_abnormal_cell_adhesion0.90012604
41MP0002971_abnormal_brown_adipose0.89146239
42MP0002168_other_aberrant_phenotype0.89053470
43MP0005275_abnormal_skin_tensile0.88906761
44MP0005332_abnormal_amino_acid0.88071820
45MP0003936_abnormal_reproductive_system0.87449348
46MP0001849_ear_inflammation0.87241412
47MP0009384_cardiac_valve_regurgitation0.87125508
48MP0000639_abnormal_adrenal_gland0.82337881
49MP0000490_abnormal_crypts_of0.82021570
50MP0000609_abnormal_liver_physiology0.81657153
51MP0005334_abnormal_fat_pad0.80692518
52MP0001958_emphysema0.80100026
53MP0002970_abnormal_white_adipose0.77746039
54MP0005076_abnormal_cell_differentiation0.76086180
55MP0008770_decreased_survivor_rate0.75847671
56MP0005636_abnormal_mineral_homeostasis0.73775141
57MP0005381_digestive/alimentary_phenotyp0.73670029
58MP0000013_abnormal_adipose_tissue0.73205023
59MP0003075_altered_response_to0.70496386
60MP0002396_abnormal_hematopoietic_system0.70275822
61MP0002896_abnormal_bone_mineralization0.69515534
62MP0003045_fibrosis0.69509877
63MP0003448_altered_tumor_morphology0.69151007
64MP0003690_abnormal_glial_cell0.67237492
65MP0004947_skin_inflammation0.64182597
66MP0009643_abnormal_urine_homeostasis0.63445996
67MP0003959_abnormal_lean_body0.63015760
68MP0002078_abnormal_glucose_homeostasis0.61786795
69MP0009278_abnormal_bone_marrow0.60915341
70MP0003656_abnormal_erythrocyte_physiolo0.59839732
71MP0005171_absent_coat_pigmentation0.59635481
72MP0003950_abnormal_plasma_membrane0.59284158
73MP0005023_abnormal_wound_healing0.58838331
74MP0000003_abnormal_adipose_tissue0.58043003
75MP0005452_abnormal_adipose_tissue0.57482228
76MP0001216_abnormal_epidermal_layer0.55484829
77MP0002332_abnormal_exercise_endurance0.54355740
78MP0001177_atelectasis0.52767868
79MP0001765_abnormal_ion_homeostasis0.51184187
80MP0002282_abnormal_trachea_morphology0.50512002
81MP0002166_altered_tumor_susceptibility0.50314986
82MP0005319_abnormal_enzyme/_coenzyme0.49793674
83MP0002060_abnormal_skin_morphology0.49608034
84MP0005164_abnormal_response_to0.48276871
85MP0003453_abnormal_keratinocyte_physiol0.47311416
86MP0005165_increased_susceptibility_to0.45122669
87MP0006054_spinal_hemorrhage0.44643440
88MP0003948_abnormal_gas_homeostasis0.43985896
89MP0009931_abnormal_skin_appearance0.43812017
90MP0001533_abnormal_skeleton_physiology0.41126324
91MP0005408_hypopigmentation0.40484078
92MP0010771_integument_phenotype0.39067571
93MP0001756_abnormal_urination0.38831585
94MP0000427_abnormal_hair_cycle0.38737658
95MP0001851_eye_inflammation0.38264159
96MP0000750_abnormal_muscle_regeneration0.37320610
97MP0002133_abnormal_respiratory_system0.37173501
98MP0005388_respiratory_system_phenotype0.37173501
99MP0001879_abnormal_lymphatic_vessel0.36032817
100MP0005448_abnormal_energy_balance0.34968312

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of purine metabolism (HP:0004352)6.28150153
2Amelogenesis imperfecta (HP:0000705)5.62937541
3Gout (HP:0001997)5.38942185
4Axonal loss (HP:0003447)5.28740594
5Congenital ichthyosiform erythroderma (HP:0007431)4.90385987
6Thin bony cortex (HP:0002753)4.69964874
7Overgrowth (HP:0001548)4.22866443
8Abnormality of calcium-phosphate metabolism (HP:0100530)3.88743644
9Abnormality of nucleobase metabolism (HP:0010932)3.81908767
10Nephritis (HP:0000123)3.74047243
11Stridor (HP:0010307)3.69301719
12Pili torti (HP:0003777)3.64650699
13Metaphyseal dysplasia (HP:0100255)3.59320157
14Tubulointerstitial nephritis (HP:0001970)3.40750856
15Protuberant abdomen (HP:0001538)3.37407701
16Enlarged epiphyses (HP:0010580)3.27100149
17Abnormality of renal excretion (HP:0011036)3.25363184
18Right ventricular cardiomyopathy (HP:0011663)3.22783234
19Aortic aneurysm (HP:0004942)3.20445861
20Neurodegeneration (HP:0002180)3.19509294
21Subcapsular cataract (HP:0000523)3.11678357
22Abnormality of renal resorption (HP:0011038)3.06605162
23Curly hair (HP:0002212)3.05819960
24Ectropion (HP:0000656)3.01484341
25Tubulointerstitial fibrosis (HP:0005576)2.96789192
26Cerebral aneurysm (HP:0004944)2.93206225
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.90892883
28Bone cyst (HP:0012062)2.83141389
29Ketoacidosis (HP:0001993)2.76932266
30Glomerulosclerosis (HP:0000096)2.76076575
31Turricephaly (HP:0000262)2.73404756
32Hyperglycinemia (HP:0002154)2.71925131
33Hyperglycinuria (HP:0003108)2.65531310
34Aortic dissection (HP:0002647)2.64033528
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.63536359
36Epiphyseal dysplasia (HP:0002656)2.52604271
37Buphthalmos (HP:0000557)2.52201528
38Abnormal auditory evoked potentials (HP:0006958)2.51375039
39Asymmetry of the thorax (HP:0001555)2.51183666
40Increased purine levels (HP:0004368)2.47820635
41Hyperuricemia (HP:0002149)2.47820635
42Deep venous thrombosis (HP:0002625)2.44596697
43Renal salt wasting (HP:0000127)2.42753287
44Abnormality of transition element cation homeostasis (HP:0011030)2.41638886
45Enlarged penis (HP:0000040)2.39226787
46Abdominal distention (HP:0003270)2.34594999
47Atrophic scars (HP:0001075)2.31632242
48Cortical dysplasia (HP:0002539)2.24682240
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.24262182
50Osteolytic defects of the hand bones (HP:0009699)2.24262182
51Autoamputation (HP:0001218)2.24067302
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22951373
53Poor eye contact (HP:0000817)2.22350864
54Hypoplasia of the iris (HP:0007676)2.20375254
55Nephrolithiasis (HP:0000787)2.19647897
56Aneurysm (HP:0002617)2.17573270
57Premature skin wrinkling (HP:0100678)2.17478538
58Tubular atrophy (HP:0000092)2.17080848
59Widely patent fontanelles and sutures (HP:0004492)2.16728679
60Wide cranial sutures (HP:0010537)2.15013522
61Long toe (HP:0010511)2.13527084
62Abnormal hair laboratory examination (HP:0003328)2.13273696
63Conjunctival hamartoma (HP:0100780)2.12920676
64Ketosis (HP:0001946)2.11859613
65Abnormality of glycine metabolism (HP:0010895)2.08629609
66Abnormality of serine family amino acid metabolism (HP:0010894)2.08629609
67Abnormality of vision evoked potentials (HP:0000649)2.07630723
68Abnormality of dental color (HP:0011073)2.07566496
69Vacuolated lymphocytes (HP:0001922)2.06442831
70Postnatal microcephaly (HP:0005484)2.06013178
71Hypoplasia of dental enamel (HP:0006297)2.05996097
72Premature loss of primary teeth (HP:0006323)2.05777628
73Biliary tract neoplasm (HP:0100574)2.01403762
74Abnormality of the dental pulp (HP:0006479)2.00121956
75Arterial tortuosity (HP:0005116)1.99573938
76Increased serum ferritin (HP:0003281)1.94605863
77Back pain (HP:0003418)1.93276266
78Impaired social interactions (HP:0000735)1.89941777
79Abnormal social behavior (HP:0012433)1.89941777
80Abnormality of the intrinsic pathway (HP:0010989)1.89366147
81Epidermoid cyst (HP:0200040)1.88907301
82Polar cataract (HP:0010696)1.88218168
83Ankle contracture (HP:0006466)1.87654565
84Abnormality of the costochondral junction (HP:0000919)1.86385350
85Cortical visual impairment (HP:0100704)1.84731878
86Macroorchidism (HP:0000053)1.81128418
87Symptomatic seizures (HP:0011145)1.80381240
88Vascular tortuosity (HP:0004948)1.79783806
89Protrusio acetabuli (HP:0003179)1.79548978
90Striae distensae (HP:0001065)1.79163422
91Fatigue (HP:0012378)1.78630437
92Xanthomatosis (HP:0000991)1.77324370
93Gingival overgrowth (HP:0000212)1.76617471
94Milia (HP:0001056)1.76210934
95Onycholysis (HP:0001806)1.74593991
96Abnormality of the anterior chamber (HP:0000593)1.74200414
97Esophageal varix (HP:0002040)1.72413907
98Abnormality of glycolysis (HP:0004366)1.72077005
99Increased serum pyruvate (HP:0003542)1.72077005
100Irritability (HP:0000737)1.71110601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK15.64009067
2CAMK1D5.52338387
3PKN25.43387601
4TRIB34.42369372
5CAMK1G4.39413532
6EEF2K3.46657519
7PDK42.78974459
8PDK32.78974459
9ERN12.61836366
10NME22.37855320
11PTK62.30207747
12PIK3CA1.97547492
13BCKDK1.97082373
14RIPK11.83669631
15PDK21.82696800
16PDGFRB1.76697011
17LATS11.65710697
18TGFBR21.54039645
19MAPKAPK31.52029841
20EPHB11.49287618
21ZAP701.49097057
22DAPK21.48204631
23PRKAA21.45528370
24RET1.42011805
25LRRK21.33111836
26MAP3K71.30831569
27STK391.14487366
28STK381.08289449
29DDR21.07710136
30BMX0.98472132
31EPHA30.93611302
32RPS6KB20.91997230
33WNK40.90334233
34TRPM70.83867841
35FRK0.78998652
36FER0.78046044
37STK38L0.71476891
38MAPKAPK50.71459353
39PTK20.68135769
40MATK0.67921374
41PRKAA10.67748849
42TBK10.65771841
43MAPK120.65347708
44GSK3A0.65161398
45JAK20.63240304
46CAMK10.61959753
47MYLK0.60513091
48JAK30.58730228
49MET0.57981494
50MAP3K20.56965823
51PDGFRA0.56290587
52JAK10.54136856
53FLT30.53590899
54TYRO30.53262865
55IGF1R0.52131375
56RPS6KA20.49366393
57CSNK1A10.47805345
58FGFR40.47722057
59CSF1R0.47495297
60CAMKK10.46248819
61FGR0.43514783
62PDPK10.42717776
63LMTK20.41964934
64PAK20.41129525
65MTOR0.40701543
66PDK10.39862905
67STK30.38181163
68MAPK110.37271996
69PRKD10.37073839
70RPS6KB10.32128083
71ILK0.31714048
72PTK2B0.30948920
73GRK60.30921836
74NEK90.30483942
75DAPK30.29260425
76LATS20.29046982
77SRC0.28527457
78TTN0.28062182
79IRAK30.27530298
80KSR20.27244209
81CSK0.26964064
82PRKCZ0.26705845
83PIM10.25371460
84SCYL20.24714093
85MST1R0.23960305
86EGFR0.23604108
87FGFR30.21019518
88SGK4940.20839731
89SGK2230.20839731
90WNK10.19584225
91CDK60.19568033
92BTK0.18452679
93DAPK10.14638581
94TIE10.14607318
95MAP3K10.13963811
96KIT0.13899512
97INSR0.12932709
98PIK3CG0.12082844
99CHUK0.11573618
100PRKACG0.09597163

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000619.31791925
2Caffeine metabolism_Homo sapiens_hsa002328.53406824
3Galactose metabolism_Homo sapiens_hsa000523.32181386
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.18141331
5Fatty acid metabolism_Homo sapiens_hsa012122.61055439
6Propanoate metabolism_Homo sapiens_hsa006402.35176301
7Pyruvate metabolism_Homo sapiens_hsa006202.15897137
8Prolactin signaling pathway_Homo sapiens_hsa049172.03610939
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71549337
10PPAR signaling pathway_Homo sapiens_hsa033201.69478207
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64653003
12Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.60924465
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21202844
14Fatty acid elongation_Homo sapiens_hsa000621.15676961
15Steroid biosynthesis_Homo sapiens_hsa001001.15264104
16N-Glycan biosynthesis_Homo sapiens_hsa005101.14629011
17Fatty acid degradation_Homo sapiens_hsa000711.05562796
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01299544
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00071275
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96185319
21Carbon metabolism_Homo sapiens_hsa012000.90555017
22Adipocytokine signaling pathway_Homo sapiens_hsa049200.88326712
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82311159
24Protein export_Homo sapiens_hsa030600.82141951
25AMPK signaling pathway_Homo sapiens_hsa041520.79670841
26Insulin resistance_Homo sapiens_hsa049310.75445897
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74804451
28Fat digestion and absorption_Homo sapiens_hsa049750.74548070
29Drug metabolism - other enzymes_Homo sapiens_hsa009830.69427451
30Peroxisome_Homo sapiens_hsa041460.68797490
31Sulfur relay system_Homo sapiens_hsa041220.67440511
32Pentose phosphate pathway_Homo sapiens_hsa000300.65745734
33Glycerolipid metabolism_Homo sapiens_hsa005610.63805803
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49468813
35Arginine biosynthesis_Homo sapiens_hsa002200.48906708
36Folate biosynthesis_Homo sapiens_hsa007900.46404116
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45392380
38Insulin signaling pathway_Homo sapiens_hsa049100.44796467
39Butanoate metabolism_Homo sapiens_hsa006500.44130921
40Amoebiasis_Homo sapiens_hsa051460.43949078
41Biosynthesis of amino acids_Homo sapiens_hsa012300.43805417
42Glucagon signaling pathway_Homo sapiens_hsa049220.41765639
43Central carbon metabolism in cancer_Homo sapiens_hsa052300.38991751
44mTOR signaling pathway_Homo sapiens_hsa041500.38977202
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37497054
46Pancreatic cancer_Homo sapiens_hsa052120.37486105
47Gastric acid secretion_Homo sapiens_hsa049710.36403876
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36009174
49ECM-receptor interaction_Homo sapiens_hsa045120.34989010
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34374072
51Acute myeloid leukemia_Homo sapiens_hsa052210.33991797
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33341019
53Toxoplasmosis_Homo sapiens_hsa051450.33190996
54Chronic myeloid leukemia_Homo sapiens_hsa052200.32039028
55Vibrio cholerae infection_Homo sapiens_hsa051100.31236148
56Nitrogen metabolism_Homo sapiens_hsa009100.31146321
57Mineral absorption_Homo sapiens_hsa049780.30406639
58Hepatitis C_Homo sapiens_hsa051600.28975176
59Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28118107
60Vitamin digestion and absorption_Homo sapiens_hsa049770.27135105
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26507144
62Tight junction_Homo sapiens_hsa045300.26398932
63Endocytosis_Homo sapiens_hsa041440.25587286
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24736897
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.24336147
66Focal adhesion_Homo sapiens_hsa045100.23971886
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23889332
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.23752202
69Bile secretion_Homo sapiens_hsa049760.23241206
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.22523551
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22347815
72VEGF signaling pathway_Homo sapiens_hsa043700.21356000
73Lysosome_Homo sapiens_hsa041420.20816295
74Small cell lung cancer_Homo sapiens_hsa052220.20641457
75Collecting duct acid secretion_Homo sapiens_hsa049660.19982643
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19784049
77Rheumatoid arthritis_Homo sapiens_hsa053230.19714395
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.19380950
79Renal cell carcinoma_Homo sapiens_hsa052110.17647474
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17194636
81Bladder cancer_Homo sapiens_hsa052190.16471431
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15901052
83HIF-1 signaling pathway_Homo sapiens_hsa040660.15848008
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.14338744
85Colorectal cancer_Homo sapiens_hsa052100.12813544
86Phagosome_Homo sapiens_hsa041450.12102645
87Proteoglycans in cancer_Homo sapiens_hsa052050.10635323
88Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10250183
89Renin secretion_Homo sapiens_hsa049240.08739647
90Endometrial cancer_Homo sapiens_hsa052130.08693188
91ABC transporters_Homo sapiens_hsa020100.07781201
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.07731982
93Tuberculosis_Homo sapiens_hsa051520.07576407
94Hepatitis B_Homo sapiens_hsa051610.07499304
95Type II diabetes mellitus_Homo sapiens_hsa049300.07481110
96Metabolic pathways_Homo sapiens_hsa011000.06741691
97beta-Alanine metabolism_Homo sapiens_hsa004100.06013507
98Synaptic vesicle cycle_Homo sapiens_hsa047210.05765820
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.05732217
100Tryptophan metabolism_Homo sapiens_hsa003800.05477968

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