GLT8D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glycosyltransferase family. The specific function of this protein has not been determined. Alternative splicing results in multiple transcript variants of this gene NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.94917137
2fusion of sperm to egg plasma membrane (GO:0007342)6.86593934
3axonemal dynein complex assembly (GO:0070286)6.21614578
4epithelial cilium movement (GO:0003351)6.11709458
5acrosome reaction (GO:0007340)5.94251269
6sperm motility (GO:0030317)5.89909890
7multicellular organism reproduction (GO:0032504)5.68283711
8acrosome assembly (GO:0001675)5.63933995
9cilium movement (GO:0003341)5.61732819
10piRNA metabolic process (GO:0034587)5.59464588
11plasma membrane fusion (GO:0045026)5.25937946
12sperm-egg recognition (GO:0035036)5.07849688
13motile cilium assembly (GO:0044458)4.97291699
14cell wall macromolecule catabolic process (GO:0016998)4.89463555
15cell wall macromolecule metabolic process (GO:0044036)4.89463555
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.83823543
17male meiosis (GO:0007140)4.59334258
18DNA methylation involved in gamete generation (GO:0043046)4.50212300
19spermatid development (GO:0007286)4.49218965
20reproduction (GO:0000003)4.44467708
21intraciliary transport (GO:0042073)4.34605892
22binding of sperm to zona pellucida (GO:0007339)4.33891716
23cell-cell recognition (GO:0009988)4.33539789
24COPII vesicle coating (GO:0048208)4.30672223
25regulation of cilium movement (GO:0003352)4.19800648
26single fertilization (GO:0007338)3.97045615
27synaptonemal complex organization (GO:0070193)3.93332179
28axoneme assembly (GO:0035082)3.87310094
29sperm capacitation (GO:0048240)3.78019345
30protein localization to cilium (GO:0061512)3.68926973
31chondrocyte proliferation (GO:0035988)3.67694226
32G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.66996442
33synaptonemal complex assembly (GO:0007130)3.57928167
34calcium ion-dependent exocytosis (GO:0017156)3.53168008
35left/right pattern formation (GO:0060972)3.35287847
36protein carboxylation (GO:0018214)3.35257307
37peptidyl-glutamic acid carboxylation (GO:0017187)3.35257307
38extracellular fibril organization (GO:0043206)3.34524736
39fertilization (GO:0009566)3.32882395
40peptidyl-proline hydroxylation (GO:0019511)3.31778027
41sequestering of extracellular ligand from receptor (GO:0035581)3.25133080
42regulation of plasminogen activation (GO:0010755)3.24366724
43COPI coating of Golgi vesicle (GO:0048205)3.23546066
44Golgi transport vesicle coating (GO:0048200)3.23546066
45cilium morphogenesis (GO:0060271)3.23532008
46nucleoside diphosphate catabolic process (GO:0009134)3.23320985
47cilium organization (GO:0044782)3.22674068
48ventricular system development (GO:0021591)3.21114860
49cilium assembly (GO:0042384)3.19146121
50skin morphogenesis (GO:0043589)3.19057341
51male meiosis I (GO:0007141)3.19026443
52mesenchymal-epithelial cell signaling (GO:0060638)3.09743212
53type B pancreatic cell proliferation (GO:0044342)3.08763632
54negative regulation of fibrinolysis (GO:0051918)3.07901596
55limb development (GO:0060173)3.04586004
56appendage development (GO:0048736)3.04586004
57negative regulation of inclusion body assembly (GO:0090084)3.02270424
58spermatogenesis (GO:0007283)3.01783287
59male gamete generation (GO:0048232)2.99568309
60signal peptide processing (GO:0006465)2.97123672
61regulation of fibrinolysis (GO:0051917)2.96790066
62cell adhesion mediated by integrin (GO:0033627)2.95776552
63protein hydroxylation (GO:0018126)2.93862412
64cell recognition (GO:0008037)2.91960296
65positive regulation of smoothened signaling pathway (GO:0045880)2.91365629
66retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91219851
67cellular component assembly involved in morphogenesis (GO:0010927)2.89630783
68limb bud formation (GO:0060174)2.89159249
69photoreceptor cell differentiation (GO:0046530)2.88698955
70eye photoreceptor cell differentiation (GO:0001754)2.88698955
71spermatid nucleus differentiation (GO:0007289)2.88116572
72regulation of protein activation cascade (GO:2000257)2.87650625
73regulation of microtubule-based movement (GO:0060632)2.86503639
74type B pancreatic cell development (GO:0003323)2.86500971
75positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86330339
76vesicle coating (GO:0006901)2.86025896
77regulation of complement activation (GO:0030449)2.85694824
78positive regulation of collagen biosynthetic process (GO:0032967)2.84860264
79negative regulation of chondrocyte differentiation (GO:0032331)2.84752894
80lactate metabolic process (GO:0006089)2.84116593
81regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.82032316
82bone trabecula formation (GO:0060346)2.81384368
83somite development (GO:0061053)2.80987162
84gamete generation (GO:0007276)2.79658587
85positive regulation of mitochondrial fission (GO:0090141)2.79421895
86spinal cord motor neuron differentiation (GO:0021522)2.78524494
87protein heterotrimerization (GO:0070208)2.77133485
88retinal rod cell development (GO:0046548)2.77011755
89negative regulation of complement activation (GO:0045916)2.76636284
90negative regulation of protein activation cascade (GO:2000258)2.75836139
91smoothened signaling pathway (GO:0007224)2.75206114
92peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.73641649
93cellular process involved in reproduction in multicellular organism (GO:0022412)2.72603232
94tonic smooth muscle contraction (GO:0014820)2.68341904
95calcium ion import (GO:0070509)2.67986248
96artery smooth muscle contraction (GO:0014824)2.67242841
97nonmotile primary cilium assembly (GO:0035058)2.65050417
98germ cell development (GO:0007281)2.64975535
99positive regulation of collagen metabolic process (GO:0010714)2.64821778
100fibril organization (GO:0097435)2.63664287
101chondrocyte development (GO:0002063)2.61280709
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60738620
103microtubule severing (GO:0051013)2.59600015
104regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.58100588
105glomerular basement membrane development (GO:0032836)2.57526424
106presynaptic membrane assembly (GO:0097105)2.57352929
107neuron projection extension involved in neuron projection guidance (GO:1902284)2.56128651
108axon extension involved in axon guidance (GO:0048846)2.56128651
109negative regulation of glycogen biosynthetic process (GO:0045719)2.55060077
1104-hydroxyproline metabolic process (GO:0019471)2.52178584
111endodermal cell differentiation (GO:0035987)2.52063462
112blood vessel maturation (GO:0001955)2.49613348
113meiotic nuclear division (GO:0007126)2.49354138
114regulation of type B pancreatic cell apoptotic process (GO:2000674)2.48897546
115chondroitin sulfate catabolic process (GO:0030207)2.48839900
116neuron cell-cell adhesion (GO:0007158)2.48362505
117axon ensheathment in central nervous system (GO:0032291)2.47349711
118central nervous system myelination (GO:0022010)2.47349711
119GTP biosynthetic process (GO:0006183)2.46432209
120protein N-linked glycosylation via asparagine (GO:0018279)2.43255469
121negative regulation of humoral immune response (GO:0002921)2.43188020
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.42738431
123mannosylation (GO:0097502)2.41405219
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.41322539
125seminiferous tubule development (GO:0072520)2.41033868
126chromosome organization involved in meiosis (GO:0070192)2.40616054
127peptidyl-asparagine modification (GO:0018196)2.40527934
128protein N-linked glycosylation (GO:0006487)2.37727472
129vascular smooth muscle contraction (GO:0014829)2.36690526
130aldehyde catabolic process (GO:0046185)2.35739272
131response to pheromone (GO:0019236)2.35403909
132keratan sulfate catabolic process (GO:0042340)2.35162638
133membrane budding (GO:0006900)2.33218124
134regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32823083
135nucleoside diphosphate phosphorylation (GO:0006165)2.32799526
136meiosis I (GO:0007127)2.32755133
137apoptotic cell clearance (GO:0043277)2.32466930
138basement membrane organization (GO:0071711)2.31976888
139import into cell (GO:0098657)2.31662321
140muscle cell migration (GO:0014812)2.31430162
141extracellular negative regulation of signal transduction (GO:1900116)2.31428302
142extracellular regulation of signal transduction (GO:1900115)2.31428302
143ER to Golgi vesicle-mediated transport (GO:0006888)2.30634193
144positive regulation of meiosis (GO:0045836)2.30251608
145ER overload response (GO:0006983)2.30173417
146meiotic cell cycle (GO:0051321)2.30160302
147postsynaptic membrane organization (GO:0001941)2.30038274
148centriole assembly (GO:0098534)2.28739566
149regulation of cholesterol metabolic process (GO:0090181)2.28558367
150regulation of cytokine production involved in inflammatory response (GO:1900015)2.27887752
151ganglion development (GO:0061548)2.27838673
152peptide hormone processing (GO:0016486)2.27820916
153pyrimidine dimer repair (GO:0006290)2.27388943
154collagen metabolic process (GO:0032963)2.27132155
155genitalia morphogenesis (GO:0035112)2.25918574
156protein maturation by protein folding (GO:0022417)2.25864190
157glandular epithelial cell development (GO:0002068)2.25860372
158fibrinolysis (GO:0042730)2.25127666
159collagen fibril organization (GO:0030199)2.24616936
160activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.24414347
161protein retention in ER lumen (GO:0006621)2.22965472
162bone development (GO:0060348)2.22805600
163regulation of metalloenzyme activity (GO:0048552)2.22560759
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.22366004
165L-phenylalanine metabolic process (GO:0006558)2.22366004
166regulation of cholesterol biosynthetic process (GO:0045540)2.22351005
167establishment of tissue polarity (GO:0007164)2.21897172
168establishment of planar polarity (GO:0001736)2.21897172
169microtubule-based movement (GO:0007018)2.21356413
170lung vasculature development (GO:0060426)2.21166121
171single strand break repair (GO:0000012)2.20658571
172regulation of chondrocyte differentiation (GO:0032330)2.20544309
173regulation of extracellular matrix disassembly (GO:0010715)2.20468932
174mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.19456560
175positive regulation of osteoblast proliferation (GO:0033690)2.19164468
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.18594147
177L-phenylalanine catabolic process (GO:0006559)2.18594147
178nucleotide transmembrane transport (GO:1901679)2.16408587
179ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.16402151

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29488259
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.69097498
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.33661339
4GBX2_23144817_ChIP-Seq_PC3_Human3.30813498
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.20361064
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94247691
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.79395571
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.43287845
9PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.38343033
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.33756809
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29443995
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.24841149
13ZNF274_21170338_ChIP-Seq_K562_Hela2.16834878
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15078182
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.13722767
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08851750
17CLOCK_20551151_ChIP-Seq_293T_Human2.03962329
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99021910
19TP53_18474530_ChIP-ChIP_U2OS_Human1.95348226
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.95004716
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88081145
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82710954
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.81542295
24FUS_26573619_Chip-Seq_HEK293_Human1.80307850
25TAF15_26573619_Chip-Seq_HEK293_Human1.79415839
26BRD4_25478319_ChIP-Seq_HGPS_Human1.78167917
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70515028
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.69358473
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.67728619
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66222808
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.65476944
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63960117
33CJUN_26792858_Chip-Seq_BT549_Human1.62004640
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61472049
35NANOG_18555785_Chip-Seq_ESCs_Mouse1.59475440
36TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59262531
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.59136898
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57966468
39SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57410840
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57144256
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57023599
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56296986
43* GABP_17652178_ChIP-ChIP_JURKAT_Human1.55924533
44ELK1_19687146_ChIP-ChIP_HELA_Human1.55499777
45P300_19829295_ChIP-Seq_ESCs_Human1.54463887
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54170917
47NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54170917
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.53674740
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52394703
50SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52217784
51RNF2_27304074_Chip-Seq_NSC_Mouse1.52120915
52SMAD4_21799915_ChIP-Seq_A2780_Human1.50478717
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50440931
54SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.47921105
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47229634
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46706270
57P53_22387025_ChIP-Seq_ESCs_Mouse1.46435123
58ER_23166858_ChIP-Seq_MCF-7_Human1.46232221
59JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46074354
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45783461
61VDR_22108803_ChIP-Seq_LS180_Human1.44949175
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44899741
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44860591
64SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44582507
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44511923
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43939570
67IGF1R_20145208_ChIP-Seq_DFB_Human1.43616256
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43336813
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42039790
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.41894112
71MTF2_20144788_ChIP-Seq_MESCs_Mouse1.41766722
72ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41720826
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.40830279
74HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.38069855
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.38017099
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37519382
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36992270
78RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36475147
79* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34735765
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34330669
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.34033286
82SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33827483
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.33342486
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33229539
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33147474
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.32987328
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.32963997
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32146290
89CMYC_18555785_Chip-Seq_ESCs_Mouse1.30234678
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29965905
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.29825737
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29684766
93E2F1_18555785_Chip-Seq_ESCs_Mouse1.28603907
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26812249
95REST_21632747_ChIP-Seq_MESCs_Mouse1.25501428
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24939974
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24880449
98WT1_19549856_ChIP-ChIP_CCG9911_Human1.24821349
99P300_18555785_Chip-Seq_ESCs_Mouse1.24675123
100* GABP_19822575_ChIP-Seq_HepG2_Human1.24129990
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24055028
102EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24055028
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24052141
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23524077
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23257999
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23206071
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.23000851
108KDM2B_26808549_Chip-Seq_REH_Human1.22972169
109KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21675163
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21498701
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21368404
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.19104765
113DCP1A_22483619_ChIP-Seq_HELA_Human1.18617840
114* TCF4_23295773_ChIP-Seq_U87_Human1.17576416
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17456055
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.16298713
117STAT3_23295773_ChIP-Seq_U87_Human1.16259423
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14982099
119KLF4_18555785_Chip-Seq_ESCs_Mouse1.14926959
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14456497
121SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13575955
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12880972
123CBP_20019798_ChIP-Seq_JUKART_Human1.11606816
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11606816
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.11385868
126MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11235174
127EP300_21415370_ChIP-Seq_HL-1_Mouse1.10819828
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.10778742
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.10607199
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10300770
131RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10114949
132RUNX2_22187159_ChIP-Seq_PCA_Human1.09699004
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09692298
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08312899
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.08028515
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07928294
137CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07866361
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07502621
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07181442
140SOX17_20123909_ChIP-Seq_XEN_Mouse1.06173094
141EOMES_21245162_ChIP-Seq_HESCs_Human1.05633296
142ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05522584
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05399044
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04219091
145ZFX_18555785_Chip-Seq_ESCs_Mouse1.04098704
146PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02983312
147RXR_22158963_ChIP-Seq_LIVER_Mouse1.01020207
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00660503
149ZNF263_19887448_ChIP-Seq_K562_Human0.99185224
150TP53_16413492_ChIP-PET_HCT116_Human0.98898802
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98436233
152TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96604691
153SOX2_20726797_ChIP-Seq_SW620_Human0.96402805
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94038354
155CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93938505
156EWS_26573619_Chip-Seq_HEK293_Human0.92661756
157SA1_22415368_ChIP-Seq_MEFs_Mouse0.92116908
158SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92094385
159SMAD_19615063_ChIP-ChIP_OVARY_Human0.90808620
160TP53_22127205_ChIP-Seq_IMR90_Human0.89470896
161HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87267145
162AR_21909140_ChIP-Seq_LNCAP_Human0.85987379
163RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85339639
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.84090863
165FOXA2_19822575_ChIP-Seq_HepG2_Human0.83873850
166NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82484494
167NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.80872616
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80621417
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79002142
170TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78487438
171CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78030045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.49133962
2MP0005503_abnormal_tendon_morphology3.17161884
3MP0008438_abnormal_cutaneous_collagen2.82778960
4MP0008877_abnormal_DNA_methylation2.34990002
5MP0010386_abnormal_urinary_bladder2.30231912
6MP0003698_abnormal_male_reproductive2.29470279
7MP0006054_spinal_hemorrhage2.29432143
8MP0009780_abnormal_chondrocyte_physiolo2.25674054
9MP0010368_abnormal_lymphatic_system2.22715820
10MP0001958_emphysema2.20650138
11MP0010030_abnormal_orbit_morphology2.17149711
12MP0006292_abnormal_olfactory_placode2.13540670
13MP0005646_abnormal_pituitary_gland2.10884590
14MP0003122_maternal_imprinting2.05037688
15MP0001929_abnormal_gametogenesis2.03424895
16MP0000013_abnormal_adipose_tissue1.91938422
17MP0004134_abnormal_chest_morphology1.90286160
18MP0006072_abnormal_retinal_apoptosis1.87472450
19MP0005645_abnormal_hypothalamus_physiol1.87295347
20MP0003283_abnormal_digestive_organ1.86351701
21MP0004272_abnormal_basement_membrane1.79286857
22MP0001542_abnormal_bone_strength1.76457710
23MP0005623_abnormal_meninges_morphology1.72173936
24MP0003880_abnormal_central_pattern1.70270727
25MP0008789_abnormal_olfactory_epithelium1.68801132
26MP0005379_endocrine/exocrine_gland_phen1.68532644
27MP0004270_analgesia1.60876297
28MP0002233_abnormal_nose_morphology1.57356497
29MP0002282_abnormal_trachea_morphology1.55616069
30MP0002638_abnormal_pupillary_reflex1.54238722
31MP0002653_abnormal_ependyma_morphology1.51951314
32MP0001986_abnormal_taste_sensitivity1.47373796
33MP0005171_absent_coat_pigmentation1.47084837
34MP0002210_abnormal_sex_determination1.46653698
35MP0009250_abnormal_appendicular_skeleto1.44864570
36MP0001661_extended_life_span1.43797941
37MP0003195_calcinosis1.41192803
38MP0000631_abnormal_neuroendocrine_gland1.40846726
39MP0002234_abnormal_pharynx_morphology1.40141845
40MP0005360_urolithiasis1.37747708
41MP0003705_abnormal_hypodermis_morpholog1.37182454
42MP0000678_abnormal_parathyroid_gland1.37160264
43MP0004145_abnormal_muscle_electrophysio1.34220983
44MP0002909_abnormal_adrenal_gland1.34046542
45MP0005423_abnormal_somatic_nervous1.29411412
46MP0002896_abnormal_bone_mineralization1.29386804
47MP0003566_abnormal_cell_adhesion1.27927503
48MP0005085_abnormal_gallbladder_physiolo1.25728299
49MP0008875_abnormal_xenobiotic_pharmacok1.25135509
50MP0001299_abnormal_eye_distance/1.24200125
51MP0000049_abnormal_middle_ear1.23257648
52MP0002938_white_spotting1.21477940
53MP0005365_abnormal_bile_salt1.19484044
54MP0002108_abnormal_muscle_morphology1.18347017
55MP0005499_abnormal_olfactory_system1.17414157
56MP0005394_taste/olfaction_phenotype1.17414157
57MP0006276_abnormal_autonomic_nervous1.17131206
58MP0003755_abnormal_palate_morphology1.17039047
59MP0004043_abnormal_pH_regulation1.16675965
60MP0000163_abnormal_cartilage_morphology1.15983779
61MP0002734_abnormal_mechanical_nocicepti1.15861805
62MP0000462_abnormal_digestive_system1.13965134
63MP0001145_abnormal_male_reproductive1.12436546
64MP0005508_abnormal_skeleton_morphology1.11141452
65MP0005408_hypopigmentation1.10793431
66MP0002060_abnormal_skin_morphology1.09502891
67MP0002139_abnormal_hepatobiliary_system1.09109449
68MP0009384_cardiac_valve_regurgitation1.08986551
69MP0002161_abnormal_fertility/fecundity1.08698519
70MP0000778_abnormal_nervous_system1.07559077
71MP0005253_abnormal_eye_physiology1.06469280
72MP0005275_abnormal_skin_tensile1.05370496
73MP0000534_abnormal_ureter_morphology1.05326463
74MP0003183_abnormal_peptide_metabolism1.04992278
75MP0004133_heterotaxia1.04337552
76MP0000762_abnormal_tongue_morphology1.04092975
77MP0000566_synostosis1.04038562
78MP0005409_darkened_coat_color1.04034762
79MP0005551_abnormal_eye_electrophysiolog1.03501113
80MP0001915_intracranial_hemorrhage1.03003865
81MP0001944_abnormal_pancreas_morphology1.02997086
82MP0001188_hyperpigmentation1.02994079
83MP0002272_abnormal_nervous_system1.02820824
84MP0001243_abnormal_dermal_layer1.01612448
85MP0002009_preneoplasia1.00418640
86MP0002876_abnormal_thyroid_physiology1.00311331
87MP0002933_joint_inflammation1.00216487
88MP0001270_distended_abdomen0.99694934
89MP0001502_abnormal_circadian_rhythm0.99635152
90MP0000653_abnormal_sex_gland0.99547807
91MP0001879_abnormal_lymphatic_vessel0.98589416
92MP0004885_abnormal_endolymph0.97613139
93MP0003868_abnormal_feces_composition0.96238274
94MP0002116_abnormal_craniofacial_bone0.95626989
95MP0001486_abnormal_startle_reflex0.94966098
96MP0000569_abnormal_digit_pigmentation0.94274510
97MP0003937_abnormal_limbs/digits/tail_de0.93297908
98MP0003787_abnormal_imprinting0.92919491
99MP0003121_genomic_imprinting0.92832143
100MP0001984_abnormal_olfaction0.92535702
101MP0003942_abnormal_urinary_system0.92086111
102MP0001485_abnormal_pinna_reflex0.91291557
103MP0002572_abnormal_emotion/affect_behav0.90983172
104MP0002693_abnormal_pancreas_physiology0.90668853
105MP0001963_abnormal_hearing_physiology0.90415409
106MP0000428_abnormal_craniofacial_morphol0.90345463
107MP0002115_abnormal_skeleton_extremities0.90246724
108MP0000920_abnormal_myelination0.89852209
109MP0005023_abnormal_wound_healing0.89415758
110MP0005670_abnormal_white_adipose0.89297866
111MP0005220_abnormal_exocrine_pancreas0.88522900
112MP0001905_abnormal_dopamine_level0.86752299
113MP0003635_abnormal_synaptic_transmissio0.86617430
114MP0003634_abnormal_glial_cell0.86430229
115MP0003115_abnormal_respiratory_system0.86222385
116MP0000639_abnormal_adrenal_gland0.85180640
117MP0002177_abnormal_outer_ear0.85127511
118MP0002837_dystrophic_cardiac_calcinosis0.85032041
119MP0003279_aneurysm0.84793819
120MP0000026_abnormal_inner_ear0.84744933
121MP0000767_abnormal_smooth_muscle0.84238720
122MP0000955_abnormal_spinal_cord0.84200750
123MP0003950_abnormal_plasma_membrane0.84169924
124MP0005197_abnormal_uvea_morphology0.83144987
125MP0005257_abnormal_intraocular_pressure0.81937505
126MP0002067_abnormal_sensory_capabilities0.80935165
127MP0003935_abnormal_craniofacial_develop0.80429486
128MP0002163_abnormal_gland_morphology0.80427225
129MP0000681_abnormal_thyroid_gland0.80373244
130MP0002102_abnormal_ear_morphology0.79127662
131MP0009046_muscle_twitch0.78949962
132MP0002160_abnormal_reproductive_system0.77875243
133MP0000358_abnormal_cell_content/0.77753699
134MP0003385_abnormal_body_wall0.77417233
135MP0002295_abnormal_pulmonary_circulatio0.76965601
136MP0004742_abnormal_vestibular_system0.76936579
137MP0005391_vision/eye_phenotype0.76780665
138MP0001529_abnormal_vocalization0.76593930
139MP0000751_myopathy0.74945699
140MP0010329_abnormal_lipoprotein_level0.74386972
141MP0000432_abnormal_head_morphology0.73097564
142MP0001666_abnormal_nutrient_absorption0.72374489
143MP0002109_abnormal_limb_morphology0.71979344
144MP0002932_abnormal_joint_morphology0.71661279
145MP0004858_abnormal_nervous_system0.70984865
146MP0005083_abnormal_biliary_tract0.67798767
147MP0003941_abnormal_skin_development0.66391363
148MP0002168_other_aberrant_phenotype0.66291314
149MP0000003_abnormal_adipose_tissue0.66169379
150MP0002090_abnormal_vision0.62298712
151MP0001286_abnormal_eye_development0.62133608
152MP0002113_abnormal_skeleton_development0.61126249
153MP0002114_abnormal_axial_skeleton0.60998528
154MP0005248_abnormal_Harderian_gland0.60268099
155MP0002092_abnormal_eye_morphology0.60254296

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.88135518
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.63388782
3Absent/shortened dynein arms (HP:0200106)6.63388782
4Abnormal respiratory motile cilium physiology (HP:0012261)5.61013448
5Protrusio acetabuli (HP:0003179)5.59893657
6Abnormal respiratory motile cilium morphology (HP:0005938)5.19990068
7Abnormal respiratory epithelium morphology (HP:0012253)5.19990068
8Abnormal ciliary motility (HP:0012262)4.99095552
9Rhinitis (HP:0012384)4.70727204
10Aortic dissection (HP:0002647)3.88253535
11Soft skin (HP:0000977)3.65898480
12Nephronophthisis (HP:0000090)3.55710912
13Chronic bronchitis (HP:0004469)3.54366294
14Abnormality of dentin (HP:0010299)3.53578917
15Vascular tortuosity (HP:0004948)3.49694834
16Infertility (HP:0000789)3.31554109
17Epiphyseal dysplasia (HP:0002656)3.23274471
18Atrophic scars (HP:0001075)3.22175950
19Arterial tortuosity (HP:0005116)3.19682865
20Abnormality of calcium-phosphate metabolism (HP:0100530)3.17431286
21Molar tooth sign on MRI (HP:0002419)3.12514432
22Abnormality of midbrain morphology (HP:0002418)3.12514432
23Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.10738184
24Medial flaring of the eyebrow (HP:0010747)3.06572581
25Retinal dysplasia (HP:0007973)3.03743278
26Bladder diverticulum (HP:0000015)2.99688112
27Flat capital femoral epiphysis (HP:0003370)2.98375056
28Type II lissencephaly (HP:0007260)2.92287359
29Occipital encephalocele (HP:0002085)2.91898730
30Vertebral compression fractures (HP:0002953)2.82633129
31Irregular epiphyses (HP:0010582)2.74022753
32Abnormality of the renal medulla (HP:0100957)2.72120931
33Fibular hypoplasia (HP:0003038)2.68767620
34Ankle contracture (HP:0006466)2.66682616
35Wormian bones (HP:0002645)2.66233752
36Mitral stenosis (HP:0001718)2.63722715
37Coronal craniosynostosis (HP:0004440)2.62937183
38True hermaphroditism (HP:0010459)2.60578857
39Pancreatic fibrosis (HP:0100732)2.56459954
40Tubulointerstitial nephritis (HP:0001970)2.52553017
41Hypoplastic ischia (HP:0003175)2.47965890
42Aortic aneurysm (HP:0004942)2.46220388
43Aplasia/Hypoplasia of the lens (HP:0008063)2.44701265
44Cervical subluxation (HP:0003308)2.42067844
45Abnormality of the acetabulum (HP:0003170)2.40214806
46Short femoral neck (HP:0100864)2.33315405
47Hypothermia (HP:0002045)2.30147385
48Absent epiphyses (HP:0010577)2.24729120
49Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.24729120
50Abnormal delivery (HP:0001787)2.24296353
51Bell-shaped thorax (HP:0001591)2.22879868
52Vitreoretinal degeneration (HP:0000655)2.19750149
53Abnormality of the ischium (HP:0003174)2.19564601
54Aortic regurgitation (HP:0001659)2.15393414
55Bronchiectasis (HP:0002110)2.15208042
56Delayed epiphyseal ossification (HP:0002663)2.14730843
57Broad metatarsal (HP:0001783)2.13285176
58Cardiovascular calcification (HP:0011915)2.12862546
59Short nail (HP:0001799)2.11323696
60Deep venous thrombosis (HP:0002625)2.10745786
61Abnormality of femoral epiphyses (HP:0006499)2.10671707
62Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.10671707
63Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.09893998
64Congenital primary aphakia (HP:0007707)2.08384775
65Abnormal spermatogenesis (HP:0008669)2.08025578
66Blue sclerae (HP:0000592)2.08014836
67Gait imbalance (HP:0002141)2.07626490
68Hyperextensible skin (HP:0000974)2.07089388
69Fragile skin (HP:0001030)2.06291396
70Small epiphyses (HP:0010585)2.06139697
71Breech presentation (HP:0001623)2.06010737
72Abnormality of molar (HP:0011077)2.05592650
73Abnormality of molar morphology (HP:0011070)2.05592650
74Osteomalacia (HP:0002749)2.04364412
75Abnormality of the epiphysis of the femoral head (HP:0010574)2.03055681
76Abnormality of the femoral head (HP:0003368)2.00133018
77Abnormality of the vertebral endplates (HP:0005106)1.99807832
78Hand muscle atrophy (HP:0009130)1.99492683
79Metaphyseal irregularity (HP:0003025)1.98928127
80Absent frontal sinuses (HP:0002688)1.98915536
81Neonatal short-limb short stature (HP:0008921)1.98858607
82Nonprogressive disorder (HP:0003680)1.97048119
83Ulnar bowing (HP:0003031)1.97023140
84Abnormality of skull ossification (HP:0002703)1.94409612
85Peritonitis (HP:0002586)1.93997554
86Symptomatic seizures (HP:0011145)1.93474946
87Chronic hepatic failure (HP:0100626)1.93315380
88Biconcave vertebral bodies (HP:0004586)1.93204954
89Abnormality of permanent molar morphology (HP:0011071)1.92930303
90Abnormality of the dental root (HP:0006486)1.92930303
91Taurodontia (HP:0000679)1.92930303
92Nephrogenic diabetes insipidus (HP:0009806)1.92641662
93Irregular vertebral endplates (HP:0003301)1.91569700
94Joint stiffness (HP:0001387)1.91405654
95Abnormality of the dental pulp (HP:0006479)1.91034758
96Patchy hypopigmentation of hair (HP:0011365)1.89772760
97Postaxial foot polydactyly (HP:0001830)1.89690778
98Flattened epiphyses (HP:0003071)1.89224930
99Azoospermia (HP:0000027)1.88860691
100Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.87378476
101Polydipsia (HP:0001959)1.86652944
102Abnormal drinking behavior (HP:0030082)1.86652944
103Delayed gross motor development (HP:0002194)1.84136958
104Congenital hepatic fibrosis (HP:0002612)1.83998258
105Back pain (HP:0003418)1.83977237
106Bowel diverticulosis (HP:0005222)1.82062626
107Shallow orbits (HP:0000586)1.81893818
108Wide anterior fontanel (HP:0000260)1.80834568
109Rhizomelia (HP:0008905)1.80781638
110Complement deficiency (HP:0004431)1.79580019
111Aplasia/Hypoplasia of the tongue (HP:0010295)1.79279997
112Inguinal hernia (HP:0000023)1.78885286
113Decreased skull ossification (HP:0004331)1.78808623
114Short thorax (HP:0010306)1.78662683
115Metaphyseal dysplasia (HP:0100255)1.78427599
116Genu varum (HP:0002970)1.78127954
117Postaxial hand polydactyly (HP:0001162)1.77999332
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77987422
119Abnormality of incisor morphology (HP:0011063)1.77868634
120Renal dysplasia (HP:0000110)1.77553313
121Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76763642
122Vertebral hypoplasia (HP:0008417)1.76763642
123Dilatation of the ascending aorta (HP:0005111)1.76485638
124Mild short stature (HP:0003502)1.75902428
125Hemiparesis (HP:0001269)1.75825733
126Mucopolysacchariduria (HP:0008155)1.74825376
127Urinary glycosaminoglycan excretion (HP:0003541)1.74825376
128Genu recurvatum (HP:0002816)1.73916255
129Aplasia/Hypoplasia of the fibula (HP:0006492)1.73663209
130Micromelia (HP:0002983)1.71675151
131Coxa vara (HP:0002812)1.71266163
132Recurrent corneal erosions (HP:0000495)1.71222030
133Osteoarthritis (HP:0002758)1.71184589
134Stage 5 chronic kidney disease (HP:0003774)1.70999263
135Morphological abnormality of the middle ear (HP:0008609)1.70819491
136Pancreatic cysts (HP:0001737)1.70603700
137Abnormality of the intrinsic pathway (HP:0010989)1.69539594
138Joint laxity (HP:0001388)1.68964170
139Genital tract atresia (HP:0001827)1.68563226
140Tubulointerstitial abnormality (HP:0001969)1.68492352
141Insulin-resistant diabetes mellitus (HP:0000831)1.68468309
142Atelectasis (HP:0100750)1.67517731
143Wrist flexion contracture (HP:0001239)1.67475847
144Cystic liver disease (HP:0006706)1.66889101
145Cerebellar dysplasia (HP:0007033)1.66785833
146Vaginal atresia (HP:0000148)1.66456111
147Cupped ribs (HP:0000887)1.64908089
148Median cleft lip (HP:0000161)1.64043612
149Spondylolisthesis (HP:0003302)1.63155951
150Spinal rigidity (HP:0003306)1.62844906
151Premature rupture of membranes (HP:0001788)1.62616846
152Follicular hyperkeratosis (HP:0007502)1.62090400
153Hypobetalipoproteinemia (HP:0003563)1.61693522
154Beaking of vertebral bodies (HP:0004568)1.61339236
155Large for gestational age (HP:0001520)1.60194831
156Infantile muscular hypotonia (HP:0008947)1.59341544
157White forelock (HP:0002211)1.59175344
158Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57387018
159Long toe (HP:0010511)1.57227851
160Nephropathy (HP:0000112)1.56769055
161Elbow flexion contracture (HP:0002987)1.53940800
162Abnormality of polysaccharide metabolism (HP:0011012)1.51509978
163Abnormality of glycosaminoglycan metabolism (HP:0004371)1.51509978
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.51509978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.36348751
2TNIK3.55764684
3NEK93.45184789
4PRKD33.34835045
5WNK42.86348756
6LIMK12.82605906
7PDK42.77270654
8PDK32.77270654
9MAPK152.61728734
10STK392.49811256
11BMPR1B2.27457823
12PASK2.14245810
13MET2.03627288
14CASK2.02758371
15SCYL22.01053803
16NTRK31.99405104
17STK38L1.95609582
18NEK61.94526488
19IRAK11.91386376
20EIF2AK31.85201061
21EIF2AK11.83067595
22MAPK131.73748817
23INSRR1.72134802
24PTK21.69179335
25MAP3K61.66272589
26IRAK21.66035731
27PIM21.63904191
28PNCK1.63592743
29ERBB41.57096703
30PAK41.55294575
31MAP2K71.51897077
32LATS11.51239311
33CSNK1G31.50494341
34TESK11.47394838
35PDK21.41135875
36CSNK1G11.40671091
37MAPKAPK51.39524232
38MUSK1.37169391
39CSNK1G21.35448205
40FLT31.34224149
41IRAK41.31898451
42PTK2B1.30851877
43CDK191.29558682
44MAPKAPK31.28521775
45UHMK11.27252663
46BMPR21.26555490
47TGFBR21.24437789
48ERN11.21224623
49MAP3K121.20810696
50CSNK1A1L1.20537241
51SRPK11.19757560
52HIPK21.16933721
53STK381.15644298
54PIK3CG1.15563028
55DDR21.12798128
56ERBB31.10531038
57DYRK31.10307930
58FRK1.06784026
59WNK31.06165102
60WNK11.06142381
61CAMKK21.05598762
62PINK11.02591222
63TRIM280.99969527
64NUAK10.99709003
65VRK10.99358671
66MKNK20.99094019
67MST40.97778934
68MAP2K40.97641974
69PRKD20.95659338
70DYRK1A0.93632498
71CDK30.92961961
72CAMK1G0.92776038
73AKT30.91260053
74LMTK20.91230435
75MYLK0.90718588
76PRKCE0.90680681
77ICK0.90434340
78TAOK30.86698226
79YES10.85343441
80NTRK10.84077525
81EPHB20.83656977
82PAK30.83535849
83PAK60.81815758
84CDC42BPA0.79504884
85EPHA20.79497858
86SGK2230.79432809
87SGK4940.79432809
88EPHB10.78399502
89MKNK10.78370778
90TIE10.77428962
91CDK80.76049792
92NEK10.75390386
93EPHA40.74661862
94MAP3K40.74425865
95CDK60.74384181
96PRKG10.73978449
97FGFR20.73572761
98IRAK30.72070221
99BCKDK0.71320142
100PLK20.69628944
101BCR0.69178090
102BRAF0.68861610
103FER0.68453673
104SIK20.67122802
105PLK10.66543582
106DYRK1B0.65729538
107OXSR10.65381063
108ABL20.65299538
109ZAK0.64124745
110BRSK20.63541342
111PRKCG0.62928719
112MARK10.62454840
113EPHA30.61630680
114NEK20.61120420
115CAMK2D0.61103009
116PRPF4B0.60914637
117WEE10.59908011
118MARK20.59566955
119TTK0.59341880
120PDGFRB0.58968006
121CAMK2A0.58828118
122FGFR10.58667789
123STK30.57563756
124ADRBK10.57283092
125CDK140.56992623
126SGK20.55348167
127MINK10.52636908
128NTRK20.52546531
129FES0.50395664
130MAP4K20.50231802
131NLK0.50116227
132TEC0.50093939
133CDK11A0.49424780
134DYRK20.48724379
135TGFBR10.47575199
136CAMK2B0.46561086
137PLK40.46119004
138RET0.45818485
139MOS0.45493122
140CDK150.45192294
141CDK180.44510820
142AURKA0.43321761
143TRPM70.43092577
144PRKACA0.42578668
145PDGFRA0.42205471
146PKN10.41517862
147PIK3CA0.41306196
148RAF10.39779375
149MAP3K50.38154648
150MST1R0.37651451
151SRC0.37627164
152ROCK10.37610767
153RPS6KB10.37261427
154CDK50.36469575
155ROCK20.35501098
156PRKAA10.34694173
157CSF1R0.33253915
158SGK10.33160037
159TSSK60.33016736
160ADRBK20.32860249
161CAMK10.31450192
162CLK10.28283609
163GRK70.27988825
164PAK20.26108593

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.38436506
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.89002623
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88841480
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.22882247
5Complement and coagulation cascades_Homo sapiens_hsa046102.21092466
6Sphingolipid metabolism_Homo sapiens_hsa006002.21068157
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.08755937
8N-Glycan biosynthesis_Homo sapiens_hsa005102.03286010
9Insulin secretion_Homo sapiens_hsa049111.97626369
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94388671
11Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.91885147
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81927194
13Amphetamine addiction_Homo sapiens_hsa050311.76113483
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.70240711
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68269021
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67730670
17ECM-receptor interaction_Homo sapiens_hsa045121.65621744
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.65259448
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65140269
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62811883
21Butanoate metabolism_Homo sapiens_hsa006501.59844979
22Nicotine addiction_Homo sapiens_hsa050331.57883292
23Cocaine addiction_Homo sapiens_hsa050301.57868160
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55755019
25Circadian entrainment_Homo sapiens_hsa047131.53324471
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.52443472
27Propanoate metabolism_Homo sapiens_hsa006401.47999482
28Taste transduction_Homo sapiens_hsa047421.47680860
29Basal transcription factors_Homo sapiens_hsa030221.47413051
30Tyrosine metabolism_Homo sapiens_hsa003501.45591423
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.45432023
32Vitamin B6 metabolism_Homo sapiens_hsa007501.45107819
33Vibrio cholerae infection_Homo sapiens_hsa051101.42359483
34Chemical carcinogenesis_Homo sapiens_hsa052041.41035333
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39270451
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36078860
37Protein digestion and absorption_Homo sapiens_hsa049741.35932161
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34616665
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34352992
40Serotonergic synapse_Homo sapiens_hsa047261.33920735
41Glutathione metabolism_Homo sapiens_hsa004801.33265278
42Morphine addiction_Homo sapiens_hsa050321.33102269
43Other glycan degradation_Homo sapiens_hsa005111.31614294
44GABAergic synapse_Homo sapiens_hsa047271.31580605
45Ether lipid metabolism_Homo sapiens_hsa005651.27712743
46Pyruvate metabolism_Homo sapiens_hsa006201.26362765
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24619310
48Peroxisome_Homo sapiens_hsa041461.24403607
49Glutamatergic synapse_Homo sapiens_hsa047241.23902778
50Fatty acid metabolism_Homo sapiens_hsa012121.23202162
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21407805
52Renin secretion_Homo sapiens_hsa049241.21215174
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20888832
54Fatty acid degradation_Homo sapiens_hsa000711.19012902
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18932924
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18798895
57Hedgehog signaling pathway_Homo sapiens_hsa043401.17708369
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16346036
59Retinol metabolism_Homo sapiens_hsa008301.14886497
60Fatty acid elongation_Homo sapiens_hsa000621.14139539
61Linoleic acid metabolism_Homo sapiens_hsa005911.13790778
62Dopaminergic synapse_Homo sapiens_hsa047281.13125137
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10305659
64Thyroid hormone synthesis_Homo sapiens_hsa049181.06817555
65Long-term potentiation_Homo sapiens_hsa047201.04684862
66TGF-beta signaling pathway_Homo sapiens_hsa043501.04372417
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03448176
68Folate biosynthesis_Homo sapiens_hsa007901.01730090
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.01684417
70Sulfur relay system_Homo sapiens_hsa041221.01319742
71Arginine and proline metabolism_Homo sapiens_hsa003300.95786668
72Biosynthesis of amino acids_Homo sapiens_hsa012300.95473993
73Ovarian steroidogenesis_Homo sapiens_hsa049130.95188054
74Hippo signaling pathway_Homo sapiens_hsa043900.94749012
75Phenylalanine metabolism_Homo sapiens_hsa003600.94281088
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94199844
77cAMP signaling pathway_Homo sapiens_hsa040240.93793138
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92319476
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.91420173
80Calcium signaling pathway_Homo sapiens_hsa040200.90580536
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90374183
82Huntingtons disease_Homo sapiens_hsa050160.90235259
83Fanconi anemia pathway_Homo sapiens_hsa034600.89317846
84Dorso-ventral axis formation_Homo sapiens_hsa043200.89190135
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87044619
86Axon guidance_Homo sapiens_hsa043600.86002670
87p53 signaling pathway_Homo sapiens_hsa041150.86000046
88Phototransduction_Homo sapiens_hsa047440.85687019
89Carbon metabolism_Homo sapiens_hsa012000.84586779
90Glucagon signaling pathway_Homo sapiens_hsa049220.84465732
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83587266
92Lysosome_Homo sapiens_hsa041420.83189645
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82981681
94Caffeine metabolism_Homo sapiens_hsa002320.82742155
95Pancreatic secretion_Homo sapiens_hsa049720.82139684
96Wnt signaling pathway_Homo sapiens_hsa043100.81885647
97Arachidonic acid metabolism_Homo sapiens_hsa005900.81696908
98Long-term depression_Homo sapiens_hsa047300.81232398
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79531898
100Non-homologous end-joining_Homo sapiens_hsa034500.78705693
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78561145
102Purine metabolism_Homo sapiens_hsa002300.76221195
103Salivary secretion_Homo sapiens_hsa049700.75206592
104Fructose and mannose metabolism_Homo sapiens_hsa000510.74550581
105Circadian rhythm_Homo sapiens_hsa047100.72316891
106beta-Alanine metabolism_Homo sapiens_hsa004100.72055444
107Cholinergic synapse_Homo sapiens_hsa047250.71133423
108Olfactory transduction_Homo sapiens_hsa047400.71005866
109Metabolic pathways_Homo sapiens_hsa011000.70958892
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69782660
111Oxidative phosphorylation_Homo sapiens_hsa001900.69537827
112Alzheimers disease_Homo sapiens_hsa050100.68099961
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67507291
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67456985
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67446751
116Cardiac muscle contraction_Homo sapiens_hsa042600.67181459
117Histidine metabolism_Homo sapiens_hsa003400.66178333
118Phagosome_Homo sapiens_hsa041450.65447400
119Focal adhesion_Homo sapiens_hsa045100.64679059
120Alcoholism_Homo sapiens_hsa050340.63448636
121Gastric acid secretion_Homo sapiens_hsa049710.61676784
122Fatty acid biosynthesis_Homo sapiens_hsa000610.61617735
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.60109541
124Oocyte meiosis_Homo sapiens_hsa041140.59815540
125Mineral absorption_Homo sapiens_hsa049780.59585472
126Renin-angiotensin system_Homo sapiens_hsa046140.58938564
127Nucleotide excision repair_Homo sapiens_hsa034200.58680323
128Estrogen signaling pathway_Homo sapiens_hsa049150.58540793
129Basal cell carcinoma_Homo sapiens_hsa052170.58230950
130Ras signaling pathway_Homo sapiens_hsa040140.58018215
131Sulfur metabolism_Homo sapiens_hsa009200.57712364
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57285260
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56811161
134Starch and sucrose metabolism_Homo sapiens_hsa005000.56541450
135Melanogenesis_Homo sapiens_hsa049160.53430104
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52876513
137PPAR signaling pathway_Homo sapiens_hsa033200.52853413
138Synaptic vesicle cycle_Homo sapiens_hsa047210.51956385
139Prion diseases_Homo sapiens_hsa050200.51727603
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51600134
141Regulation of autophagy_Homo sapiens_hsa041400.51539615
142Type II diabetes mellitus_Homo sapiens_hsa049300.49265884
143Dilated cardiomyopathy_Homo sapiens_hsa054140.48443475
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47488512
145Steroid biosynthesis_Homo sapiens_hsa001000.47030445
146Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46977101
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46448438
148Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46390933
149Collecting duct acid secretion_Homo sapiens_hsa049660.46358043
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.46171391
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44899117
152Inositol phosphate metabolism_Homo sapiens_hsa005620.44837314
153Parkinsons disease_Homo sapiens_hsa050120.44640715
154ABC transporters_Homo sapiens_hsa020100.44035051
155Type I diabetes mellitus_Homo sapiens_hsa049400.43917330
156Selenocompound metabolism_Homo sapiens_hsa004500.43813450
157Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43752269
158Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43381680
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.42301664
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.40864890
161Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40578865
162Proteoglycans in cancer_Homo sapiens_hsa052050.40004003
163Arginine biosynthesis_Homo sapiens_hsa002200.38450155
164Central carbon metabolism in cancer_Homo sapiens_hsa052300.38003810
165Small cell lung cancer_Homo sapiens_hsa052220.37769980
166Galactose metabolism_Homo sapiens_hsa000520.37728926

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