GLT6D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The GT6 glycosyltransferases gene family, which includes the ABO blood group (ABO; MIM 110300) and GLT6D1, shows a complex evolution pattern, with multiple events of gain and loss in different mammal species. In humans, the ABO gene is considered the sole functional member, although the O allele is null and is fixed in certain populations (summary by Casals et al. (2009) [PubMed 19218399]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.94825807
2epithelial cilium movement (GO:0003351)9.91915141
3plasma membrane fusion (GO:0045026)9.71453510
4axonemal dynein complex assembly (GO:0070286)9.51467213
5motile cilium assembly (GO:0044458)9.33367312
6reproduction (GO:0000003)9.14308058
7regulation of cilium movement (GO:0003352)8.58564021
8cilium movement (GO:0003341)7.93532656
9cilium or flagellum-dependent cell motility (GO:0001539)7.90233151
10negative regulation of inclusion body assembly (GO:0090084)7.79933256
11single fertilization (GO:0007338)7.28293389
12sperm capacitation (GO:0048240)7.12991581
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.09068670
14organic cation transport (GO:0015695)7.01298785
15spermatogenesis (GO:0007283)6.96585553
16male gamete generation (GO:0048232)6.93946016
17synaptonemal complex organization (GO:0070193)6.81830666
18microtubule depolymerization (GO:0007019)6.81639996
19synaptonemal complex assembly (GO:0007130)6.71360138
20male meiosis (GO:0007140)6.46559169
21gamete generation (GO:0007276)6.38003333
22regulation of inclusion body assembly (GO:0090083)6.36302382
23piRNA metabolic process (GO:0034587)6.34386894
24fertilization (GO:0009566)6.22258511
25calcium ion-dependent exocytosis (GO:0017156)5.87022223
26chromosome condensation (GO:0030261)5.79049990
27glycerol ether metabolic process (GO:0006662)5.64357091
28spermatid nucleus differentiation (GO:0007289)5.62086435
29DNA packaging (GO:0006323)5.47688423
30germ cell development (GO:0007281)5.45868869
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.35153883
32ether metabolic process (GO:0018904)5.21695966
33cell recognition (GO:0008037)5.05464819
34multicellular organismal reproductive process (GO:0048609)5.02688873
35ventricular system development (GO:0021591)5.02495257
36regulation of microtubule-based movement (GO:0060632)5.02125210
37sexual reproduction (GO:0019953)4.86455748
38microtubule severing (GO:0051013)4.79997951
39male meiosis I (GO:0007141)4.67820902
40single strand break repair (GO:0000012)4.66099518
41chromosome organization involved in meiosis (GO:0070192)4.54365140
42left/right pattern formation (GO:0060972)4.50632023
43seminiferous tubule development (GO:0072520)4.46595489
44DNA methylation involved in gamete generation (GO:0043046)4.18792279
45chaperone-mediated protein complex assembly (GO:0051131)4.06639797
46multicellular organismal development (GO:0007275)4.04687057
47meiotic nuclear division (GO:0007126)3.94044351
48meiosis I (GO:0007127)3.70247434
49microtubule polymerization or depolymerization (GO:0031109)3.65769400
50sequestering of actin monomers (GO:0042989)3.65363596
51protein K11-linked deubiquitination (GO:0035871)3.53009802
52protein refolding (GO:0042026)3.46270190
53genitalia morphogenesis (GO:0035112)3.41813441
54protein polyglutamylation (GO:0018095)3.40914441
55regulation of spindle checkpoint (GO:0090231)3.33434826
56protein localization to cilium (GO:0061512)3.22239062
57nucleoside diphosphate phosphorylation (GO:0006165)3.21983664
58GTP biosynthetic process (GO:0006183)3.21500739
59glycolytic process (GO:0006096)3.20950581
60RNA destabilization (GO:0050779)3.18602963
61carnitine transport (GO:0015879)3.10793096
62amino-acid betaine transport (GO:0015838)3.10793096
63nucleus organization (GO:0006997)3.10358934
64meiotic cell cycle (GO:0051321)3.09057386
65chromatin silencing (GO:0006342)3.03496966
66polyamine biosynthetic process (GO:0006596)3.01791627
67polyol catabolic process (GO:0046174)3.00423370
68positive regulation of macrophage activation (GO:0043032)2.99831779
69mitotic sister chromatid cohesion (GO:0007064)2.98761193
70interferon-gamma secretion (GO:0072643)2.92974763
71carnitine transmembrane transport (GO:1902603)2.92229751
72monoubiquitinated protein deubiquitination (GO:0035520)2.91504735
73RNA localization (GO:0006403)2.90874796
74alditol metabolic process (GO:0019400)2.86353817
75UTP biosynthetic process (GO:0006228)2.84178064
76cilium organization (GO:0044782)2.74855501
77regulation of cilium assembly (GO:1902017)2.73464655
78intraciliary transport (GO:0042073)2.73218218
79synapsis (GO:0007129)2.71675079
80microtubule-based movement (GO:0007018)2.67944085
81cellular component assembly involved in morphogenesis (GO:0010927)2.67418512
82cilium assembly (GO:0042384)2.65892889
83mitochondrion degradation (GO:0000422)2.63546244
84meiotic cell cycle process (GO:1903046)2.63207341
85UTP metabolic process (GO:0046051)2.58200815
86peptidyl-glutamic acid modification (GO:0018200)2.46723560
87cilium morphogenesis (GO:0060271)2.46637575
88calcium ion import (GO:0070509)2.44114678
89positive regulation of glycolytic process (GO:0045821)2.42967996
90axoneme assembly (GO:0035082)2.41029283
91sperm motility (GO:0030317)14.7579596
92cell wall macromolecule catabolic process (GO:0016998)13.1274635
93cell wall macromolecule metabolic process (GO:0044036)13.1274635
94fusion of sperm to egg plasma membrane (GO:0007342)12.7566075
95acrosome reaction (GO:0007340)12.6704109
96acrosome assembly (GO:0001675)11.8163766
97sperm-egg recognition (GO:0035036)11.4196807
98binding of sperm to zona pellucida (GO:0007339)10.5079082
99multicellular organism reproduction (GO:0032504)10.3655157
100cell-cell recognition (GO:0009988)10.2064753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.23602648
2EZH2_22144423_ChIP-Seq_EOC_Human4.50751000
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66657554
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.29599368
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94394772
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.92455407
7VDR_22108803_ChIP-Seq_LS180_Human2.58534561
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53811595
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48246667
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.16618502
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07495191
12ZNF274_21170338_ChIP-Seq_K562_Hela2.04758293
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04451074
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.04374384
15CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.01232428
16KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.86495187
17MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.74452543
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73976429
19STAT1_17558387_ChIP-Seq_HELA_Human1.70458261
20SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63677289
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.62090436
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.60756563
23FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59785627
24REST_21632747_ChIP-Seq_MESCs_Mouse1.54681651
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.49612673
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.47842473
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.47475737
28GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.47135845
29KDM2B_26808549_Chip-Seq_REH_Human1.46855225
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.45332775
31TAF15_26573619_Chip-Seq_HEK293_Human1.44834725
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44566015
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.43432056
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42067887
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40641688
36CBP_20019798_ChIP-Seq_JUKART_Human1.40641688
37FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33852645
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.32945596
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32546874
40TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29445330
41P53_21459846_ChIP-Seq_SAOS-2_Human1.28589549
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27057708
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27057708
44SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26917431
45TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26818619
46LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.24905960
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24216634
48GATA3_21867929_ChIP-Seq_TH1_Mouse1.22200611
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21468548
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20818311
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.20404955
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19469097
53GF1_26923725_Chip-Seq_HPCs_Mouse1.19267390
54CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18072150
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17590604
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.14974505
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12774968
58SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10638667
59MYC_27129775_Chip-Seq_CORNEA_Mouse1.10469001
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10078324
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08776626
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.08434500
63RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08348544
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08266543
65SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08251695
66ERG_20517297_ChIP-Seq_VCAP_Human1.07842690
67CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07676070
68SPI1_26923725_Chip-Seq_HPCs_Mouse1.06991542
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06566664
70JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05822451
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05301176
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03748202
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03739487
74RNF2_27304074_Chip-Seq_NSC_Mouse1.03113623
75RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01612851
76GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01026834
77OCT4_18555785_Chip-Seq_ESCs_Mouse1.00374095
78ESET_19884257_ChIP-Seq_ESCs_Mouse1.00351812
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.99397001
80CMYC_18555785_Chip-Seq_ESCs_Mouse0.99183792
81P53_22387025_ChIP-Seq_ESCs_Mouse0.99082090
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97180432
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.97092241
84SOX9_26525672_Chip-Seq_HEART_Mouse0.96930323
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96238882
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96151856
87SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95206022
88FUS_26573619_Chip-Seq_HEK293_Human0.93718668
89SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.93285238
90P300_18555785_Chip-Seq_ESCs_Mouse0.93109217
91NFYB_21822215_ChIP-Seq_K562_Human0.92550639
92OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92492320
93KLF4_18555785_Chip-Seq_ESCs_Mouse0.92350228
94* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92027391
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91913036
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91248476
97RUNX1_26923725_Chip-Seq_HPCs_Mouse0.90978487
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.89134386
99ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89026802
100STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88903022

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04295846
2MP0001929_abnormal_gametogenesis5.45911293
3MP0008877_abnormal_DNA_methylation3.79850137
4MP0002161_abnormal_fertility/fecundity3.30016899
5MP0002210_abnormal_sex_determination3.19436471
6MP0005670_abnormal_white_adipose2.86494776
7MP0001145_abnormal_male_reproductive2.70869747
8MP0000653_abnormal_sex_gland2.32783028
9MP0005410_abnormal_fertilization16.7272485
10MP0002653_abnormal_ependyma_morphology1.62576318
11MP0003646_muscle_fatigue1.53320086
12MP0002160_abnormal_reproductive_system1.46174905
13MP0004233_abnormal_muscle_weight1.31575617
14MP0005623_abnormal_meninges_morphology1.14171152
15MP0002282_abnormal_trachea_morphology1.12189788
16MP0001765_abnormal_ion_homeostasis1.12077949
17MP0009046_muscle_twitch1.04993652
18MP0002234_abnormal_pharynx_morphology0.99259189
19MP0001984_abnormal_olfaction0.89799360
20MP0005647_abnormal_sex_gland0.85743593
21MP0003329_amyloid_beta_deposits0.81218868
22MP0002736_abnormal_nociception_after0.71651716
23MP0005389_reproductive_system_phenotype0.71591224
24MP0000569_abnormal_digit_pigmentation0.70172080
25MP0003115_abnormal_respiratory_system0.65569733
26MP0003879_abnormal_hair_cell0.62777924
27MP0004270_analgesia0.61105475
28MP0004742_abnormal_vestibular_system0.60737880
29MP0008058_abnormal_DNA_repair0.60584155
30MP0003950_abnormal_plasma_membrane0.60303463
31MP0005636_abnormal_mineral_homeostasis0.59203852
32MP0001661_extended_life_span0.57291517
33MP0005666_abnormal_adipose_tissue0.56546392
34MP0003011_delayed_dark_adaptation0.56074546
35MP0008995_early_reproductive_senescence0.55751972
36MP0005551_abnormal_eye_electrophysiolog0.54195059
37MP0003787_abnormal_imprinting0.52785465
38MP0005253_abnormal_eye_physiology0.51874856
39MP0003878_abnormal_ear_physiology0.51634694
40MP0005377_hearing/vestibular/ear_phenot0.51634694
41MP0002102_abnormal_ear_morphology0.51243932
42MP0001968_abnormal_touch/_nociception0.49877881
43MP0001324_abnormal_eye_pigmentation0.46646643
44MP0002272_abnormal_nervous_system0.46409048
45MP0004036_abnormal_muscle_relaxation0.42016410
46MP0001764_abnormal_homeostasis0.39588409
47MP0003699_abnormal_female_reproductive0.39342024
48MP0005423_abnormal_somatic_nervous0.39259250
49MP0000604_amyloidosis0.38991716
50MP0000920_abnormal_myelination0.38274482
51MP0004811_abnormal_neuron_physiology0.37830734
52MP0001293_anophthalmia0.35185140
53MP0006036_abnormal_mitochondrial_physio0.34846923
54MP0003635_abnormal_synaptic_transmissio0.34715122
55MP0004133_heterotaxia0.34280159
56MP0002572_abnormal_emotion/affect_behav0.33823607
57MP0002229_neurodegeneration0.33704509
58MP0002928_abnormal_bile_duct0.33646090
59MP0002269_muscular_atrophy0.32989610
60MP0000534_abnormal_ureter_morphology0.31659741
61MP0002139_abnormal_hepatobiliary_system0.31524903
62MP0005391_vision/eye_phenotype0.30959025
63MP0002152_abnormal_brain_morphology0.30579876
64MP0003633_abnormal_nervous_system0.30202916
65MP0008569_lethality_at_weaning0.29270225
66MP0002169_no_abnormal_phenotype0.28869706
67MP0002873_normal_phenotype0.28807977
68MP0003631_nervous_system_phenotype0.28643252
69MP0002063_abnormal_learning/memory/cond0.28108999
70MP0009745_abnormal_behavioral_response0.27717665
71MP0006072_abnormal_retinal_apoptosis0.27602377
72MP0000358_abnormal_cell_content/0.27554947
73MP0002971_abnormal_brown_adipose0.27248446
74MP0009115_abnormal_fat_cell0.26675641
75MP0009278_abnormal_bone_marrow0.26613834
76MP0001486_abnormal_startle_reflex0.26571633
77MP0000751_myopathy0.26505283
78MP0008057_abnormal_DNA_replication0.25875051
79MP0003861_abnormal_nervous_system0.25785250
80MP0001440_abnormal_grooming_behavior0.24157231
81MP0001545_abnormal_hematopoietic_system0.23953285
82MP0005397_hematopoietic_system_phenotyp0.23953285
83MP0001529_abnormal_vocalization0.23613799
84MP0002295_abnormal_pulmonary_circulatio0.23558466
85MP0004145_abnormal_muscle_electrophysio0.23141282
86MP0005451_abnormal_body_composition0.21623066
87MP0003942_abnormal_urinary_system0.21223008
88MP0003632_abnormal_nervous_system0.20982921
89MP0001986_abnormal_taste_sensitivity0.20978696
90MP0001727_abnormal_embryo_implantation0.20958579
91MP0001963_abnormal_hearing_physiology0.20792100
92MP0004859_abnormal_synaptic_plasticity0.20717481
93MP0006035_abnormal_mitochondrial_morpho0.20585102
94MP0002067_abnormal_sensory_capabilities0.20513099
95MP0002882_abnormal_neuron_morphology0.20395177
96MP0000015_abnormal_ear_pigmentation0.19900054
97MP0002752_abnormal_somatic_nervous0.19842247
98MP0002064_seizures0.19368423
99MP0005174_abnormal_tail_pigmentation0.19221602
100MP0005535_abnormal_body_temperature0.18889638

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.35691035
2Abnormal respiratory motile cilium morphology (HP:0005938)9.35691035
3Abnormal respiratory motile cilium physiology (HP:0012261)9.33194850
4Abnormal ciliary motility (HP:0012262)7.43808213
5Rhinitis (HP:0012384)7.17666789
6Chronic bronchitis (HP:0004469)7.15927150
7Infertility (HP:0000789)7.09898815
8Nasal polyposis (HP:0100582)6.16278610
9Abnormality of the nasal mucosa (HP:0000433)5.04773531
10Male infertility (HP:0003251)4.99454565
11Bronchitis (HP:0012387)4.39802393
12Bronchiectasis (HP:0002110)4.24417764
13Nephronophthisis (HP:0000090)3.97160016
14Abnormal spermatogenesis (HP:0008669)3.70186316
15Recurrent sinusitis (HP:0011108)3.22907219
16Recurrent otitis media (HP:0000403)3.15011324
17Tubulointerstitial nephritis (HP:0001970)3.00768091
18Abnormality of the renal medulla (HP:0100957)2.96586884
19Cholecystitis (HP:0001082)2.60377689
20Abnormal gallbladder physiology (HP:0012438)2.60377689
21Impulsivity (HP:0100710)2.58735365
22Recurrent bronchitis (HP:0002837)2.55719222
23Tubular atrophy (HP:0000092)2.44655292
24Tubulointerstitial abnormality (HP:0001969)2.44147617
25Choroideremia (HP:0001139)2.41131370
26Abnormality of midbrain morphology (HP:0002418)2.36639683
27Molar tooth sign on MRI (HP:0002419)2.36639683
28Gonadotropin excess (HP:0000837)2.24404696
29Azoospermia (HP:0000027)2.23884779
30Dyschromatopsia (HP:0007641)2.21452394
31Medial flaring of the eyebrow (HP:0010747)2.15576848
32Spastic tetraparesis (HP:0001285)2.14202240
33Decreased central vision (HP:0007663)2.10512195
34Neurofibrillary tangles (HP:0002185)2.06316494
35Congenital malformation of the right heart (HP:0011723)2.00410183
36Double outlet right ventricle (HP:0001719)2.00410183
37Dynein arm defect of respiratory motile cilia (HP:0012255)13.8089702
38Absent/shortened dynein arms (HP:0200106)13.8089702
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7288608
40Tubulointerstitial fibrosis (HP:0005576)1.86978625
41Sensory axonal neuropathy (HP:0003390)1.82213504
42Hemorrhage of the eye (HP:0011885)1.80583937
43Stage 5 chronic kidney disease (HP:0003774)1.77142323
44Abnormal drinking behavior (HP:0030082)1.69928604
45Polydipsia (HP:0001959)1.69928604
46Postaxial foot polydactyly (HP:0001830)1.65652601
47Abnormality of renal excretion (HP:0011036)1.64524150
48Cerebral inclusion bodies (HP:0100314)1.63782614
49Decreased electroretinogram (ERG) amplitude (HP:0000654)1.62703199
50Bundle branch block (HP:0011710)1.61462034
51Congenital hepatic fibrosis (HP:0002612)1.60244429
52Bile duct proliferation (HP:0001408)1.57329723
53Abnormal biliary tract physiology (HP:0012439)1.57329723
54Peripheral hypomyelination (HP:0007182)1.54149694
55Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53597116
56Heterotopia (HP:0002282)1.50836641
57Abnormality of the dental root (HP:0006486)1.44540302
58Taurodontia (HP:0000679)1.44540302
59Abnormality of permanent molar morphology (HP:0011071)1.44540302
60Abnormality of dentin (HP:0010299)1.44342773
61Exercise-induced myalgia (HP:0003738)1.43256199
62Hemiparesis (HP:0001269)1.41568617
63Asymmetric septal hypertrophy (HP:0001670)1.40861152
64Abnormal urine output (HP:0012590)1.40608096
65Oculomotor apraxia (HP:0000657)1.38690489
66Abnormality of the renal cortex (HP:0011035)1.38446555
67Aplasia/Hypoplasia of the lens (HP:0008063)1.37979539
68Short ribs (HP:0000773)1.36108208
69Bell-shaped thorax (HP:0001591)1.35462312
70Abnormality of the dental pulp (HP:0006479)1.34698049
71Fibular hypoplasia (HP:0003038)1.32785309
72Abnormality of molar (HP:0011077)1.32217937
73Abnormality of molar morphology (HP:0011070)1.32217937
74Hypercholesterolemia (HP:0003124)1.31965372
75Myoglobinuria (HP:0002913)1.31816510
76Facial cleft (HP:0002006)1.31201820
77Postaxial hand polydactyly (HP:0001162)1.30140138
78Renal dysplasia (HP:0000110)1.26292657
79Easy fatigability (HP:0003388)1.25997140
80Constricted visual fields (HP:0001133)1.23720152
81Deformed sella turcica (HP:0002681)1.23575696
82Abnormality of saccadic eye movements (HP:0000570)1.22639791
83Rhabdomyolysis (HP:0003201)1.22474498
84Abnormality of the neuromuscular junction (HP:0003398)1.20842134
85Fatigable weakness (HP:0003473)1.20842134
86Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20366875
87Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.19890297
88Absent epiphyses (HP:0010577)1.19890297
89Retrobulbar optic neuritis (HP:0100654)1.19579087
90Optic neuritis (HP:0100653)1.19579087
91Attenuation of retinal blood vessels (HP:0007843)1.18778665
92Short femoral neck (HP:0100864)1.18203353
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.17009871
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.17009871
95Retinal dysplasia (HP:0007973)1.15574709
96Abnormal ventriculo-arterial connection (HP:0011563)1.14742447
97Transposition of the great arteries (HP:0001669)1.14742447
98Abnormal connection of the cardiac segments (HP:0011545)1.14742447
99Nephropathy (HP:0000112)1.14393050
100Progressive cerebellar ataxia (HP:0002073)1.13863650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.79546735
2PDK47.79546735
3TESK16.52501129
4PRKD35.24342196
5PDK25.00140288
6ICK4.80517905
7STK392.61306571
8WNK42.24169717
9PTK2B2.12557134
10STK381.95848267
11PNCK1.89628540
12DYRK1B1.61953114
13NEK21.32453912
14PDK11.26543889
15WNK11.02129876
16IRAK10.92114111
17PDPK10.88294572
18RIPK40.85728096
19MAPK150.84143709
20TYRO30.76322500
21CCNB10.71652735
22DYRK30.71626207
23PINK10.68673883
24IRAK20.63585453
25MUSK0.62936524
26STK30.60624399
27MAP2K60.56671865
28PASK0.55664121
29NTRK20.55304339
30TESK20.55263573
31STK38L0.54319961
32TTK0.51068058
33LMTK20.49620321
34CHEK20.48818771
35EEF2K0.42566912
36PRKCG0.41911128
37PAK10.39995234
38MARK20.39100909
39MAPKAPK50.38473802
40CAMK1G0.35688769
41CHEK10.35435439
42BRSK10.33460238
43PAK20.33186839
44NEK60.30580157
45CDK150.29161943
46CLK10.28532589
47CDK180.25753173
48PRKCZ0.25618548
49CDK11A0.25406926
50CDK140.23489248
51PRKCQ0.21366641
52PAK40.21337085
53ATM0.21279640
54WEE10.20679423
55MAP3K100.20241296
56OXSR10.19790976
57MTOR0.17970524
58CASK0.17529794
59PKN10.16902612
60EPHB10.16626230
61CAMK2A0.16537068
62PRKAA10.16369989
63MAP3K40.15270066
64TNIK0.15120552
65YES10.13783745
66PRKG10.13533018
67CAMKK10.12867483
68ATR0.10101659
69CSNK1D0.10018104
70GSK3B0.09323188
71RPS6KB10.08370686
72MARK10.08134074
73BRAF0.07729916
74PRKG20.07392169
75STK110.06875102
76BRSK20.06854325
77CDC70.06423354
78PRKCB0.05966554
79MKNK20.05691704
80CSNK2A10.05664212
81PRKACG0.05580149
82EPHB20.04852072
83PRKCA0.04517640
84RPS6KA10.04359444
85PRKCD0.04280276
86CDK50.04150925
87CSNK2A20.04052758
88CSF1R0.03666525
89PRKACB0.03620666
90PRKACA0.02370429
91CDK10.01945147
92UHMK10.01933408
93RPS6KA30.01886434
94PLK10.01771297
95PAK60.01202165
96MAPK80.01167968
97CSK0.00959743
98CDK60.00950723
99PLK40.00334389
100GRK70.00071043

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.87082733
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.50818883
3Vitamin B6 metabolism_Homo sapiens_hsa007503.25937080
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17407364
5Pyruvate metabolism_Homo sapiens_hsa006203.13995265
6Linoleic acid metabolism_Homo sapiens_hsa005913.11648401
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.83647096
8Glucagon signaling pathway_Homo sapiens_hsa049222.39454070
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.38509444
10Propanoate metabolism_Homo sapiens_hsa006402.30628010
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.13548463
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.12277469
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98204145
14Glycerolipid metabolism_Homo sapiens_hsa005611.95122753
15Basal transcription factors_Homo sapiens_hsa030221.93576672
16PPAR signaling pathway_Homo sapiens_hsa033201.82117515
17Ether lipid metabolism_Homo sapiens_hsa005651.78791650
18Cardiac muscle contraction_Homo sapiens_hsa042601.70462641
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.67356748
20Amphetamine addiction_Homo sapiens_hsa050311.60645527
21Selenocompound metabolism_Homo sapiens_hsa004501.57844934
22Fatty acid metabolism_Homo sapiens_hsa012121.56931358
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53026784
24Fat digestion and absorption_Homo sapiens_hsa049751.52095661
25Fructose and mannose metabolism_Homo sapiens_hsa000511.45853559
26Mineral absorption_Homo sapiens_hsa049781.44651431
27Fatty acid degradation_Homo sapiens_hsa000711.42230831
28Oocyte meiosis_Homo sapiens_hsa041141.40502894
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36099007
30Dorso-ventral axis formation_Homo sapiens_hsa043201.31329275
31Collecting duct acid secretion_Homo sapiens_hsa049661.28963006
32Pentose phosphate pathway_Homo sapiens_hsa000301.28571029
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.26796115
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18573847
35Huntingtons disease_Homo sapiens_hsa050161.15490142
36Carbon metabolism_Homo sapiens_hsa012001.13478917
37Renin secretion_Homo sapiens_hsa049241.12604867
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07391140
39Insulin secretion_Homo sapiens_hsa049111.02105382
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.01320201
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96741285
42Hedgehog signaling pathway_Homo sapiens_hsa043400.96737013
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95318718
44Glutathione metabolism_Homo sapiens_hsa004800.95023899
45Arachidonic acid metabolism_Homo sapiens_hsa005900.93777075
46Purine metabolism_Homo sapiens_hsa002300.93578697
47Antigen processing and presentation_Homo sapiens_hsa046120.87277021
48Long-term potentiation_Homo sapiens_hsa047200.86527691
49Sulfur metabolism_Homo sapiens_hsa009200.86256587
50Bile secretion_Homo sapiens_hsa049760.82036651
51Chemical carcinogenesis_Homo sapiens_hsa052040.80247956
52Salivary secretion_Homo sapiens_hsa049700.80017464
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.79283331
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77879611
55Thyroid hormone synthesis_Homo sapiens_hsa049180.77420229
56Fanconi anemia pathway_Homo sapiens_hsa034600.74733412
57Synaptic vesicle cycle_Homo sapiens_hsa047210.74583667
58Estrogen signaling pathway_Homo sapiens_hsa049150.71158423
59Calcium signaling pathway_Homo sapiens_hsa040200.70069020
60Pancreatic secretion_Homo sapiens_hsa049720.65774394
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.63091891
62Biosynthesis of amino acids_Homo sapiens_hsa012300.61058005
63mRNA surveillance pathway_Homo sapiens_hsa030150.60437191
64Gastric acid secretion_Homo sapiens_hsa049710.58119772
65Taste transduction_Homo sapiens_hsa047420.57801499
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57150072
67Sulfur relay system_Homo sapiens_hsa041220.55547493
68Protein digestion and absorption_Homo sapiens_hsa049740.52084864
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52047810
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51645133
71Circadian entrainment_Homo sapiens_hsa047130.50755733
72RNA transport_Homo sapiens_hsa030130.49587887
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46549623
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44582384
75Metabolic pathways_Homo sapiens_hsa011000.44420743
76Endocytosis_Homo sapiens_hsa041440.43013473
77Systemic lupus erythematosus_Homo sapiens_hsa053220.42649104
78Legionellosis_Homo sapiens_hsa051340.42561076
79ABC transporters_Homo sapiens_hsa020100.40430598
80cAMP signaling pathway_Homo sapiens_hsa040240.40365393
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39025351
82Cocaine addiction_Homo sapiens_hsa050300.38322657
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.37055172
84Renin-angiotensin system_Homo sapiens_hsa046140.35282312
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34832459
86Inositol phosphate metabolism_Homo sapiens_hsa005620.33231669
87Glutamatergic synapse_Homo sapiens_hsa047240.31682385
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29045192
89Oxidative phosphorylation_Homo sapiens_hsa001900.28223341
90AMPK signaling pathway_Homo sapiens_hsa041520.23829838
91VEGF signaling pathway_Homo sapiens_hsa043700.23763906
92Alzheimers disease_Homo sapiens_hsa050100.23522008
93Alcoholism_Homo sapiens_hsa050340.21023217
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20827121
95Nicotine addiction_Homo sapiens_hsa050330.18864269
96Pyrimidine metabolism_Homo sapiens_hsa002400.18516909
97Salmonella infection_Homo sapiens_hsa051320.14933606
98Dopaminergic synapse_Homo sapiens_hsa047280.14637471
99Vibrio cholerae infection_Homo sapiens_hsa051100.11921672
100Sphingolipid metabolism_Homo sapiens_hsa006000.11248762

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