GLRB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39886554
2neuronal action potential propagation (GO:0019227)5.19318701
3synaptic vesicle exocytosis (GO:0016079)5.03645524
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.97579611
5locomotory exploration behavior (GO:0035641)4.93929696
6neuron cell-cell adhesion (GO:0007158)4.93204035
7vocalization behavior (GO:0071625)4.89308307
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85057404
9synaptic vesicle maturation (GO:0016188)4.84059733
10glutamate secretion (GO:0014047)4.72254834
11regulation of synaptic vesicle exocytosis (GO:2000300)4.69356986
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58689475
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.57673866
14sodium ion export (GO:0071436)4.57355807
15regulation of glutamate receptor signaling pathway (GO:1900449)4.41610188
16protein localization to synapse (GO:0035418)4.35682299
17glutamate receptor signaling pathway (GO:0007215)4.23657378
18regulation of synaptic vesicle transport (GO:1902803)4.12547814
19synaptic transmission, glutamatergic (GO:0035249)4.08354020
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07444575
21presynaptic membrane assembly (GO:0097105)4.06551949
22neurotransmitter secretion (GO:0007269)4.04897542
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.00646198
24* neuron-neuron synaptic transmission (GO:0007270)3.99353175
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.93575621
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.93266194
27presynaptic membrane organization (GO:0097090)3.92802140
28exploration behavior (GO:0035640)3.90754169
29gamma-aminobutyric acid transport (GO:0015812)3.90386771
30L-amino acid import (GO:0043092)3.85488092
31regulation of neuronal synaptic plasticity (GO:0048168)3.83985070
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82933363
33neurotransmitter-gated ion channel clustering (GO:0072578)3.82913546
34detection of calcium ion (GO:0005513)3.80250932
35transmission of nerve impulse (GO:0019226)3.77039646
36cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.75639036
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.66925382
38potassium ion homeostasis (GO:0055075)3.63096663
39neuron recognition (GO:0008038)3.63028016
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61262150
41neurotransmitter transport (GO:0006836)3.56105499
42dendritic spine morphogenesis (GO:0060997)3.53545236
43long-term memory (GO:0007616)3.53491774
44negative regulation of dendrite morphogenesis (GO:0050774)3.53341225
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.53087448
46cellular potassium ion homeostasis (GO:0030007)3.49691969
47postsynaptic membrane organization (GO:0001941)3.48917333
48long-term synaptic potentiation (GO:0060291)3.45787189
49regulation of postsynaptic membrane potential (GO:0060078)3.44692431
50central nervous system myelination (GO:0022010)3.43951401
51axon ensheathment in central nervous system (GO:0032291)3.43951401
52positive regulation of membrane potential (GO:0045838)3.42182246
53potassium ion import (GO:0010107)3.36105277
54glycine transport (GO:0015816)3.35945458
55neuromuscular process controlling posture (GO:0050884)3.35116167
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34320128
57regulation of synaptic transmission, glutamatergic (GO:0051966)3.34031767
58cerebellar Purkinje cell differentiation (GO:0021702)3.32986802
59layer formation in cerebral cortex (GO:0021819)3.30418573
60regulation of neurotransmitter secretion (GO:0046928)3.29606337
61cerebellar granule cell differentiation (GO:0021707)3.26648267
62cellular sodium ion homeostasis (GO:0006883)3.26600913
63positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.25347347
64axonal fasciculation (GO:0007413)3.24759498
65regulation of synaptic plasticity (GO:0048167)3.23296295
66cell communication by electrical coupling (GO:0010644)3.22629785
67regulation of synapse structural plasticity (GO:0051823)3.22509591
68positive regulation of dendritic spine development (GO:0060999)3.22449807
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19475567
70regulation of neurotransmitter levels (GO:0001505)3.18941095
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.18617281
72negative regulation of neurotransmitter transport (GO:0051589)3.17280688
73proline transport (GO:0015824)3.16021068
74synaptic vesicle endocytosis (GO:0048488)3.15426070
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15133033
76positive regulation of neurotransmitter secretion (GO:0001956)3.13081016
77acidic amino acid transport (GO:0015800)3.12434079
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.10686119
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10578383
80* adult walking behavior (GO:0007628)3.10170019
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09933898
82regulation of vesicle fusion (GO:0031338)3.09162492
83regulation of neurotransmitter transport (GO:0051588)3.08422921
84membrane hyperpolarization (GO:0060081)3.08312936
85amino acid import (GO:0043090)3.07732481
86neuronal ion channel clustering (GO:0045161)3.07111587
87membrane depolarization (GO:0051899)3.05076838
88C4-dicarboxylate transport (GO:0015740)3.04233892
89regulation of dendritic spine morphogenesis (GO:0061001)3.02494687
90establishment of synaptic vesicle localization (GO:0097480)3.01683442
91synaptic vesicle transport (GO:0048489)3.01683442
92auditory behavior (GO:0031223)3.00369922
93synapse assembly (GO:0007416)3.00041591
94regulation of voltage-gated calcium channel activity (GO:1901385)2.98245990
95response to auditory stimulus (GO:0010996)2.98245481
96regulation of cell communication by electrical coupling (GO:0010649)2.93432379
97cerebellar Purkinje cell layer development (GO:0021680)2.92882460
98* synaptic transmission (GO:0007268)2.91565873
99learning (GO:0007612)2.91525536
100membrane depolarization during action potential (GO:0086010)2.90890816
101regulation of synaptic transmission, GABAergic (GO:0032228)2.89264222
102neuromuscular process controlling balance (GO:0050885)2.88381372
103response to histamine (GO:0034776)2.87666168
104neurotransmitter uptake (GO:0001504)2.86707866
105positive regulation of synapse assembly (GO:0051965)2.86553993
106dendrite morphogenesis (GO:0048813)2.86307365
107mechanosensory behavior (GO:0007638)2.86165085
108behavioral response to cocaine (GO:0048148)2.84666699
109regulation of synaptic transmission (GO:0050804)2.84481019
110neuromuscular synaptic transmission (GO:0007274)2.84148904
111negative regulation of dendrite development (GO:2000171)2.83578756
112chemosensory behavior (GO:0007635)2.82811656
113serotonin metabolic process (GO:0042428)2.82260722
114positive regulation of synaptic transmission (GO:0050806)2.82256654
115activation of protein kinase A activity (GO:0034199)2.80237613
116regulation of glutamate secretion (GO:0014048)2.79636517
117positive regulation of synapse maturation (GO:0090129)2.79400453
118behavioral defense response (GO:0002209)2.78081064
119positive regulation of neurotransmitter transport (GO:0051590)2.77480074
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77103468
121regulation of dendritic spine development (GO:0060998)2.76556126
122vesicle transport along microtubule (GO:0047496)2.76327435
123mating behavior (GO:0007617)2.75968137
124regulation of respiratory system process (GO:0044065)2.74807121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.23244817
2GBX2_23144817_ChIP-Seq_PC3_Human3.99824341
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07084803
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98722251
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94527933
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56924576
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56924576
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55600596
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47855839
10* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45348998
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.42976120
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.42573534
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40136604
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38702708
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37158924
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.33473844
17DROSHA_22980978_ChIP-Seq_HELA_Human2.23683701
18TAF15_26573619_Chip-Seq_HEK293_Human2.17871770
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.13659210
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11889565
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.06562777
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.04775825
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96953596
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96371832
25AR_21572438_ChIP-Seq_LNCaP_Human1.95341314
26* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91378966
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91024369
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84988404
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81929369
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77551561
31SMAD4_21799915_ChIP-Seq_A2780_Human1.75558509
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69093256
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69014292
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67613051
35P300_19829295_ChIP-Seq_ESCs_Human1.62827680
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62413462
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60699473
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59572021
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51769920
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.51377161
41* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48908015
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.47367270
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47173944
44* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44843985
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.44427989
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42722139
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39709576
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37941494
49STAT3_23295773_ChIP-Seq_U87_Human1.34550651
50IGF1R_20145208_ChIP-Seq_DFB_Human1.34275336
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33568073
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32557958
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29194301
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.28199157
55AR_25329375_ChIP-Seq_VCAP_Human1.27277681
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.26297124
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25577685
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24156017
59VDR_22108803_ChIP-Seq_LS180_Human1.23502112
60RNF2_27304074_Chip-Seq_NSC_Mouse1.23131477
61RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21406581
62FUS_26573619_Chip-Seq_HEK293_Human1.21205069
63* TCF4_23295773_ChIP-Seq_U87_Human1.19546591
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19530338
65ER_23166858_ChIP-Seq_MCF-7_Human1.17939059
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.16838330
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16606466
68ZNF274_21170338_ChIP-Seq_K562_Hela1.16488463
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16345177
70NANOG_18555785_Chip-Seq_ESCs_Mouse1.15687457
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15276641
72SOX9_26525672_Chip-Seq_HEART_Mouse1.15151327
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.13692088
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11985842
75ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11714009
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11123099
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.09169020
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09001323
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08684761
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08602174
81AR_19668381_ChIP-Seq_PC3_Human1.07832103
82* RUNX2_22187159_ChIP-Seq_PCA_Human1.07390083
83MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06920278
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05952515
85PRDM14_20953172_ChIP-Seq_ESCs_Human1.03946505
86TRIM28_21343339_ChIP-Seq_HEK293_Human1.03796685
87AHR_22903824_ChIP-Seq_MCF-7_Human1.03314998
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01840492
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01785604
90* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01411212
91EP300_21415370_ChIP-Seq_HL-1_Mouse1.00944600
92LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00617259
93* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00304740
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99991855
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99158540
96WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98912728
97CMYC_18555785_Chip-Seq_ESCs_Mouse0.98892112
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98747853
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98449232
100TP53_16413492_ChIP-PET_HCT116_Human0.97903129
101TP53_18474530_ChIP-ChIP_U2OS_Human0.97507740
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96916116
103POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96841186
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96841186
105* P53_22387025_ChIP-Seq_ESCs_Mouse0.96350542
106KDM2B_26808549_Chip-Seq_REH_Human0.95016881
107RING1B_27294783_Chip-Seq_NPCs_Mouse0.94911759
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94789058
109TET1_21490601_ChIP-Seq_MESCs_Mouse0.94573640
110JUN_21703547_ChIP-Seq_K562_Human0.94419870
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93212339
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92561614
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87527068

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.46206525
2MP0003880_abnormal_central_pattern5.17765644
3MP0003635_abnormal_synaptic_transmissio3.91699391
4MP0004270_analgesia3.51633452
5MP0009745_abnormal_behavioral_response3.42459270
6* MP0009046_muscle_twitch3.27810675
7MP0002064_seizures3.26421547
8MP0002063_abnormal_learning/memory/cond3.06646182
9MP0001968_abnormal_touch/_nociception2.99277170
10MP0002272_abnormal_nervous_system2.88786769
11MP0002572_abnormal_emotion/affect_behav2.75981535
12* MP0001486_abnormal_startle_reflex2.72220329
13MP0005423_abnormal_somatic_nervous2.63976503
14MP0002734_abnormal_mechanical_nocicepti2.61021368
15MP0002736_abnormal_nociception_after2.43915014
16MP0001501_abnormal_sleep_pattern2.28631405
17MP0001440_abnormal_grooming_behavior2.27236060
18MP0002822_catalepsy2.23824535
19MP0002735_abnormal_chemical_nociception2.23216644
20* MP0002067_abnormal_sensory_capabilities2.11561709
21MP0001970_abnormal_pain_threshold1.95812335
22MP0002733_abnormal_thermal_nociception1.93956352
23MP0008569_lethality_at_weaning1.92736847
24MP0001529_abnormal_vocalization1.90149821
25MP0000778_abnormal_nervous_system1.81140587
26MP0003329_amyloid_beta_deposits1.80214017
27MP0004924_abnormal_behavior1.79698053
28MP0005386_behavior/neurological_phenoty1.79698053
29MP0005171_absent_coat_pigmentation1.78265710
30MP0002184_abnormal_innervation1.76389922
31MP0005646_abnormal_pituitary_gland1.73125500
32MP0006276_abnormal_autonomic_nervous1.67404035
33* MP0002557_abnormal_social/conspecific_i1.65588053
34MP0004885_abnormal_endolymph1.64978641
35MP0001905_abnormal_dopamine_level1.62142962
36MP0009780_abnormal_chondrocyte_physiolo1.60972328
37MP0000920_abnormal_myelination1.58349848
38* MP0004142_abnormal_muscle_tone1.57394053
39MP0001188_hyperpigmentation1.56799364
40* MP0000955_abnormal_spinal_cord1.51697225
41MP0005645_abnormal_hypothalamus_physiol1.48739095
42MP0004742_abnormal_vestibular_system1.47404990
43MP0001984_abnormal_olfaction1.46107342
44* MP0002066_abnormal_motor_capabilities/c1.44792386
45MP0004811_abnormal_neuron_physiology1.44109657
46* MP0002882_abnormal_neuron_morphology1.42610057
47MP0003879_abnormal_hair_cell1.38034220
48MP0003787_abnormal_imprinting1.37639009
49MP0003633_abnormal_nervous_system1.35350696
50MP0001502_abnormal_circadian_rhythm1.27302895
51MP0003690_abnormal_glial_cell1.25595396
52MP0004858_abnormal_nervous_system1.25416198
53MP0003631_nervous_system_phenotype1.22156119
54MP0002909_abnormal_adrenal_gland1.20627939
55MP0005551_abnormal_eye_electrophysiolog1.20495160
56MP0002229_neurodegeneration1.18672919
57MP0005409_darkened_coat_color1.12838336
58MP0003136_yellow_coat_color1.11030457
59MP0001963_abnormal_hearing_physiology1.08277445
60MP0003122_maternal_imprinting1.08274035
61MP0003634_abnormal_glial_cell1.07030791
62MP0004145_abnormal_muscle_electrophysio1.06264259
63MP0001485_abnormal_pinna_reflex1.05085931
64MP0003632_abnormal_nervous_system1.02169744
65* MP0002152_abnormal_brain_morphology1.00383608
66MP0004147_increased_porphyrin_level0.97461235
67MP0010386_abnormal_urinary_bladder0.92628800
68MP0001177_atelectasis0.91236118
69MP0008872_abnormal_physiological_respon0.90818001
70MP0000569_abnormal_digit_pigmentation0.90261509
71MP0008877_abnormal_DNA_methylation0.89500992
72MP0003123_paternal_imprinting0.89420889
73* MP0002752_abnormal_somatic_nervous0.88374987
74MP0002069_abnormal_eating/drinking_beha0.84160165
75MP0000013_abnormal_adipose_tissue0.84107207
76MP0000631_abnormal_neuroendocrine_gland0.82557913
77MP0008874_decreased_physiological_sensi0.80669414
78MP0004043_abnormal_pH_regulation0.79099468
79MP0002837_dystrophic_cardiac_calcinosis0.77682921
80MP0000751_myopathy0.77097468
81MP0002090_abnormal_vision0.76021993
82MP0002876_abnormal_thyroid_physiology0.74724906
83MP0000372_irregular_coat_pigmentation0.74210056
84MP0005535_abnormal_body_temperature0.73490515
85MP0000604_amyloidosis0.73378568
86MP0002638_abnormal_pupillary_reflex0.72518315
87MP0003121_genomic_imprinting0.71270409
88MP0004085_abnormal_heartbeat0.70161789
89MP0000026_abnormal_inner_ear0.70136328
90MP0001664_abnormal_digestion0.68714806
91MP0004484_altered_response_of0.68565924
92MP0001299_abnormal_eye_distance/0.66917098
93MP0002102_abnormal_ear_morphology0.62570369
94MP0004215_abnormal_myocardial_fiber0.62541889
95MP0003283_abnormal_digestive_organ0.62357765
96MP0006072_abnormal_retinal_apoptosis0.62186064
97MP0005499_abnormal_olfactory_system0.60735642
98MP0005394_taste/olfaction_phenotype0.60735642
99MP0005253_abnormal_eye_physiology0.60494339
100MP0003137_abnormal_impulse_conducting0.58627552
101MP0001943_abnormal_respiration0.57500807
102MP0005379_endocrine/exocrine_gland_phen0.56277755
103* MP0010769_abnormal_survival0.55500826
104* MP0002082_postnatal_lethality0.55482305
105* MP0010770_preweaning_lethality0.55482305
106MP0001346_abnormal_lacrimal_gland0.55258807
107MP0002234_abnormal_pharynx_morphology0.53094256
108MP0002295_abnormal_pulmonary_circulatio0.52982786
109MP0001986_abnormal_taste_sensitivity0.52566227
110* MP0010768_mortality/aging0.52547376
111MP0003183_abnormal_peptide_metabolism0.51685387
112* MP0003956_abnormal_body_size0.50569486
113MP0000015_abnormal_ear_pigmentation0.50475819
114MP0003861_abnormal_nervous_system0.50320301

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.18090401
2Myokymia (HP:0002411)5.88875843
3Focal seizures (HP:0007359)5.54816043
4Atonic seizures (HP:0010819)5.14652296
5Febrile seizures (HP:0002373)4.95533330
6Epileptic encephalopathy (HP:0200134)4.87018426
7Visual hallucinations (HP:0002367)4.61754805
8Progressive cerebellar ataxia (HP:0002073)4.20314032
9Absence seizures (HP:0002121)4.13661474
10Dialeptic seizures (HP:0011146)3.97363684
11Generalized tonic-clonic seizures (HP:0002069)3.94842555
12Supranuclear gaze palsy (HP:0000605)3.67805575
13Action tremor (HP:0002345)3.64618063
14Broad-based gait (HP:0002136)3.58872880
15Hyperventilation (HP:0002883)3.51867404
16Gaze-evoked nystagmus (HP:0000640)3.49062985
17Dysmetria (HP:0001310)3.28238459
18Ankle clonus (HP:0011448)3.26132077
19Neurofibrillary tangles (HP:0002185)3.24106802
20Dysdiadochokinesis (HP:0002075)3.21243943
21Scanning speech (HP:0002168)3.01818053
22Truncal ataxia (HP:0002078)2.94643289
23Abnormality of the corticospinal tract (HP:0002492)2.93475068
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.88699437
25Degeneration of the lateral corticospinal tracts (HP:0002314)2.88699437
26Impaired vibration sensation in the lower limbs (HP:0002166)2.85081165
27Anxiety (HP:0000739)2.82287804
28Poor eye contact (HP:0000817)2.81528982
29Blue irides (HP:0000635)2.81437101
30Cerebral inclusion bodies (HP:0100314)2.80108325
31Spastic gait (HP:0002064)2.75643406
32Depression (HP:0000716)2.75520060
33Progressive inability to walk (HP:0002505)2.73663502
34Urinary bladder sphincter dysfunction (HP:0002839)2.73598786
35Abnormal eating behavior (HP:0100738)2.73595146
36Hemiparesis (HP:0001269)2.70657737
37Intention tremor (HP:0002080)2.67086503
38Pheochromocytoma (HP:0002666)2.64430517
39Absent speech (HP:0001344)2.59031428
40Drooling (HP:0002307)2.58677897
41Excessive salivation (HP:0003781)2.58677897
42Postural instability (HP:0002172)2.58306916
43Diplopia (HP:0000651)2.57386134
44Abnormality of binocular vision (HP:0011514)2.57386134
45Amblyopia (HP:0000646)2.56306354
46Delusions (HP:0000746)2.56160458
47Abnormality of the lower motor neuron (HP:0002366)2.53154508
48Termporal pattern (HP:0011008)2.50993060
49Insidious onset (HP:0003587)2.50993060
50Impaired social interactions (HP:0000735)2.46219563
51Abnormal social behavior (HP:0012433)2.46219563
52Urinary urgency (HP:0000012)2.43192825
53Peripheral hypomyelination (HP:0007182)2.41843960
54Fetal akinesia sequence (HP:0001989)2.41623559
55Cerebral hypomyelination (HP:0006808)2.41280899
56Limb dystonia (HP:0002451)2.37935691
57Epileptiform EEG discharges (HP:0011182)2.35534635
58Tetraplegia (HP:0002445)2.28638032
59Neuroendocrine neoplasm (HP:0100634)2.28430650
60Mutism (HP:0002300)2.28057805
61Inability to walk (HP:0002540)2.27188712
62Generalized myoclonic seizures (HP:0002123)2.27145088
63Craniofacial dystonia (HP:0012179)2.26449757
64Lower limb muscle weakness (HP:0007340)2.22307421
65EEG with generalized epileptiform discharges (HP:0011198)2.20930310
66Sleep apnea (HP:0010535)2.17775693
67Morphological abnormality of the pyramidal tract (HP:0002062)2.14906986
68Impaired smooth pursuit (HP:0007772)2.14180988
69Retinal dysplasia (HP:0007973)2.13477214
70Status epilepticus (HP:0002133)2.12627565
71Bradykinesia (HP:0002067)2.12282917
72Gait imbalance (HP:0002141)2.10575943
73Clonus (HP:0002169)2.10171873
74Megalencephaly (HP:0001355)2.09549470
75Akinesia (HP:0002304)2.09253146
76Hemiplegia (HP:0002301)2.08674006
77Genetic anticipation (HP:0003743)2.06190629
78Hypsarrhythmia (HP:0002521)2.05585143
79Diminished movement (HP:0002374)2.04561500
80Aplasia involving bones of the extremities (HP:0009825)2.03558295
81Aplasia involving bones of the upper limbs (HP:0009823)2.03558295
82Aplasia of the phalanges of the hand (HP:0009802)2.03558295
83Torticollis (HP:0000473)2.02436122
84Polyphagia (HP:0002591)2.01576934
85Sensory axonal neuropathy (HP:0003390)2.01340464
86Spastic tetraplegia (HP:0002510)2.01209647
87Apathy (HP:0000741)1.99345054
88Impaired vibratory sensation (HP:0002495)1.96344981
89Stereotypic behavior (HP:0000733)1.94764554
90Amyotrophic lateral sclerosis (HP:0007354)1.94285953
91Specific learning disability (HP:0001328)1.93535634
92Rigidity (HP:0002063)1.93054741
93Abnormality of salivation (HP:0100755)1.91684447
94Dysmetric saccades (HP:0000641)1.91421119
95Absent/shortened dynein arms (HP:0200106)1.90989063
96Dynein arm defect of respiratory motile cilia (HP:0012255)1.90989063
97Gait ataxia (HP:0002066)1.89915988
98Thickened helices (HP:0000391)1.89113905
99Papilledema (HP:0001085)1.87029153
100Agitation (HP:0000713)1.86084015
101Clumsiness (HP:0002312)1.85832149
102Bundle branch block (HP:0011710)1.85096714
103Focal dystonia (HP:0004373)1.84305945
104Poor suck (HP:0002033)1.84154733
105Abnormality of ocular smooth pursuit (HP:0000617)1.84046091
106Psychosis (HP:0000709)1.83410537
107Abnormality of saccadic eye movements (HP:0000570)1.82925666
108Postural tremor (HP:0002174)1.82672961
109Incomplete penetrance (HP:0003829)1.81066084
110Medial flaring of the eyebrow (HP:0010747)1.80182847
111Protruding tongue (HP:0010808)1.79853077
112Muscular hypotonia of the trunk (HP:0008936)1.79112323
113Congenital primary aphakia (HP:0007707)1.78998559
114Neuronal loss in central nervous system (HP:0002529)1.78921910
115Ventricular fibrillation (HP:0001663)1.78554291
116Prolonged QT interval (HP:0001657)1.77915514
117Onion bulb formation (HP:0003383)1.75961401
118Obstructive sleep apnea (HP:0002870)1.75321855
119Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75081842
120Genital tract atresia (HP:0001827)1.74838210
121Diminished motivation (HP:0000745)1.72363292
122Choreoathetosis (HP:0001266)1.69814891
123Increased circulating renin level (HP:0000848)1.69064496
124Abnormal EKG (HP:0003115)1.68933723
125Spastic tetraparesis (HP:0001285)1.66704580
126Horizontal nystagmus (HP:0000666)1.66501696
127Rapidly progressive (HP:0003678)1.62823250
128CNS hypomyelination (HP:0003429)1.61401086
129Heterochromia iridis (HP:0001100)1.61061238
130Annular pancreas (HP:0001734)1.60185233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.26848373
2EPHA43.89098921
3CASK3.45123539
4MAP3K42.95069302
5MAP3K92.93482721
6MAP2K72.81994943
7MARK12.44969517
8MINK12.23199748
9TNIK2.08807093
10MAP3K122.07888467
11DAPK22.04235768
12PAK61.99881481
13OXSR11.96391360
14CDK191.95488607
15RIPK41.84645322
16NTRK21.84260473
17NTRK11.80795044
18MAP2K41.76369388
19PRPF4B1.66789621
20PLK21.63100258
21STK391.62738259
22LIMK11.62010877
23KSR21.52096010
24CDK51.44053340
25PNCK1.41287587
26MAPK131.40872574
27GRK51.37274805
28UHMK11.35328041
29PRKD31.33851893
30FES1.31876861
31CAMKK11.29614144
32SGK2231.24681473
33SGK4941.24681473
34MAP3K131.18924628
35PRKCG1.17936193
36TESK11.16237210
37KSR11.15506411
38CAMK2A1.15383168
39CAMKK21.15325896
40ARAF1.15033517
41CAMK2B1.14313929
42BMPR21.07295903
43MAP4K21.07050179
44TYRO31.06582801
45DAPK11.06200446
46WNK11.04289083
47FRK1.00913922
48PKN10.95547834
49BCR0.92771524
50STK380.91657399
51MAP3K20.91267108
52PHKG20.90052232
53PHKG10.90052232
54NEK60.85411747
55SIK20.85019230
56CDK180.82097668
57PRKCE0.81795743
58STK110.81777325
59CAMK2D0.81717963
60SGK20.81198247
61CDK150.79857970
62PRKCH0.79766794
63CDK140.78487940
64PINK10.77704652
65CSNK1G20.75645427
66MAPKAPK50.75415495
67CAMK10.74975301
68TNK20.73877559
69FGR0.73564625
70CAMK2G0.73471646
71PAK30.73190563
72MUSK0.73021232
73CSNK1A1L0.72567841
74SGK10.72434902
75WNK40.70173348
76CDK11A0.67852238
77CAMK40.67527278
78PTK2B0.65630370
79FGFR20.65479688
80GRK70.65131879
81AKT30.64552725
82DYRK1A0.63049006
83CSNK1G10.62948743
84BRSK10.62200369
85ROCK20.61843928
86RET0.61780275
87LMTK20.58908045
88ERBB30.58214541
89ROCK10.55865639
90MARK20.54964042
91SGK30.54076701
92BRAF0.53951242
93PDPK10.52560027
94MAP3K10.50398641
95NME10.49249573
96PDK10.48845112
97CCNB10.47345286
98FYN0.46863465
99ADRBK20.46515909
100IRAK20.45778391
101RAF10.43840917
102WNK30.43199633
103RPS6KA30.40952191
104DAPK30.40150990
105MAPK100.39720478
106CSNK1D0.39392427
107PRKACA0.38811450
108PRKCZ0.38593732
109MOS0.38348986
110PRKCA0.37771374
111CDC42BPA0.37555380
112MAPK120.36819526
113FER0.36601073
114CSNK1G30.36575309
115PRKG10.36517020
116PTK20.35082938
117CSNK1A10.35057171
118LATS20.34775760
119SIK30.34055693
120DYRK20.31121647
121MYLK0.29102457
122PRKCB0.28107784

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.01118976
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35469398
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82647362
4GABAergic synapse_Homo sapiens_hsa047272.80005446
5Glutamatergic synapse_Homo sapiens_hsa047242.66353944
6Morphine addiction_Homo sapiens_hsa050322.63103875
7Circadian entrainment_Homo sapiens_hsa047132.57703273
8Olfactory transduction_Homo sapiens_hsa047402.47002446
9Long-term potentiation_Homo sapiens_hsa047202.43254274
10Amphetamine addiction_Homo sapiens_hsa050312.32443204
11Salivary secretion_Homo sapiens_hsa049702.17498190
12Dopaminergic synapse_Homo sapiens_hsa047282.07474178
13Collecting duct acid secretion_Homo sapiens_hsa049662.06164853
14Taste transduction_Homo sapiens_hsa047422.04618508
15Insulin secretion_Homo sapiens_hsa049111.93623076
16Serotonergic synapse_Homo sapiens_hsa047261.91255304
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87303666
18Long-term depression_Homo sapiens_hsa047301.85190867
19Cholinergic synapse_Homo sapiens_hsa047251.83897009
20Gastric acid secretion_Homo sapiens_hsa049711.82952337
21Renin secretion_Homo sapiens_hsa049241.64571516
22Cocaine addiction_Homo sapiens_hsa050301.61776945
23Calcium signaling pathway_Homo sapiens_hsa040201.57828249
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57294603
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48401417
26Oxytocin signaling pathway_Homo sapiens_hsa049211.47792386
27Vitamin B6 metabolism_Homo sapiens_hsa007501.39223418
28* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36619322
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36114871
30Vibrio cholerae infection_Homo sapiens_hsa051101.29428806
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28425780
32GnRH signaling pathway_Homo sapiens_hsa049121.24221228
33Axon guidance_Homo sapiens_hsa043601.23952937
34cAMP signaling pathway_Homo sapiens_hsa040241.21883623
35Gap junction_Homo sapiens_hsa045401.21471332
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20536667
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19839061
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10889734
39Cardiac muscle contraction_Homo sapiens_hsa042601.09502392
40Phototransduction_Homo sapiens_hsa047441.08920120
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08607787
42Type II diabetes mellitus_Homo sapiens_hsa049301.01432499
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98180455
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.97256087
45Oxidative phosphorylation_Homo sapiens_hsa001900.96716681
46Estrogen signaling pathway_Homo sapiens_hsa049150.95976422
47Melanogenesis_Homo sapiens_hsa049160.95963857
48ErbB signaling pathway_Homo sapiens_hsa040120.95309889
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93850233
50Pancreatic secretion_Homo sapiens_hsa049720.92306724
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92107314
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91558317
53Alzheimers disease_Homo sapiens_hsa050100.85681979
54Dorso-ventral axis formation_Homo sapiens_hsa043200.84278256
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81735907
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.81093042
57Glioma_Homo sapiens_hsa052140.80176647
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73821599
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73413105
60Butanoate metabolism_Homo sapiens_hsa006500.72776509
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70703695
62Thyroid hormone synthesis_Homo sapiens_hsa049180.68780682
63Folate biosynthesis_Homo sapiens_hsa007900.67687045
64Choline metabolism in cancer_Homo sapiens_hsa052310.66322806
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64972428
66Ras signaling pathway_Homo sapiens_hsa040140.64091140
67MAPK signaling pathway_Homo sapiens_hsa040100.64004242
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60622814
69Ether lipid metabolism_Homo sapiens_hsa005650.60406553
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.60284146
71Inositol phosphate metabolism_Homo sapiens_hsa005620.60239176
72Parkinsons disease_Homo sapiens_hsa050120.57909053
73Dilated cardiomyopathy_Homo sapiens_hsa054140.57576536
74Rheumatoid arthritis_Homo sapiens_hsa053230.57503044
75Oocyte meiosis_Homo sapiens_hsa041140.56928154
76Regulation of autophagy_Homo sapiens_hsa041400.55836369
77Nitrogen metabolism_Homo sapiens_hsa009100.54152678
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54044732
79Type I diabetes mellitus_Homo sapiens_hsa049400.53911320
80Arginine biosynthesis_Homo sapiens_hsa002200.51400242
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48035815
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47507647
83Alcoholism_Homo sapiens_hsa050340.47408935
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46573095
85Ovarian steroidogenesis_Homo sapiens_hsa049130.45554649
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44937883
87Rap1 signaling pathway_Homo sapiens_hsa040150.44419814
88beta-Alanine metabolism_Homo sapiens_hsa004100.44072535
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43105895
90Fatty acid elongation_Homo sapiens_hsa000620.42930582
91Renal cell carcinoma_Homo sapiens_hsa052110.42502493
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39139411
93Endocytosis_Homo sapiens_hsa041440.38655401
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.37657220
95Arginine and proline metabolism_Homo sapiens_hsa003300.36839252
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35891286
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34575018
98Prion diseases_Homo sapiens_hsa050200.34076817
99Sphingolipid metabolism_Homo sapiens_hsa006000.33611256
100Wnt signaling pathway_Homo sapiens_hsa043100.33611084
101African trypanosomiasis_Homo sapiens_hsa051430.33280437
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.33064389
103Protein export_Homo sapiens_hsa030600.32907228
104Hippo signaling pathway_Homo sapiens_hsa043900.32197566
105Huntingtons disease_Homo sapiens_hsa050160.32133416
106Glucagon signaling pathway_Homo sapiens_hsa049220.31973216
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31866905
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.31824858
109Phagosome_Homo sapiens_hsa041450.30968444
110Chemokine signaling pathway_Homo sapiens_hsa040620.30867250
111VEGF signaling pathway_Homo sapiens_hsa043700.30839697
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29396620
113Tight junction_Homo sapiens_hsa045300.29095382
114Circadian rhythm_Homo sapiens_hsa047100.28842305
115Bile secretion_Homo sapiens_hsa049760.28454156
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28202479
117Mineral absorption_Homo sapiens_hsa049780.27344659
118Fatty acid biosynthesis_Homo sapiens_hsa000610.25225829
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24774686

Most similar genes based on co-expression Upload to Enrichr

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