GLRA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.87272884
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.71253364
3vocalization behavior (GO:0071625)5.44710308
4dopamine transport (GO:0015872)5.13639722
5synaptic vesicle exocytosis (GO:0016079)5.10864789
6regulation of synaptic vesicle exocytosis (GO:2000300)4.73005920
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.70873729
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.61792621
9glutamate secretion (GO:0014047)4.57251711
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.56589409
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.52237660
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.49793626
13dopamine biosynthetic process (GO:0042416)4.48246904
14regulation of glutamate receptor signaling pathway (GO:1900449)4.35643197
15presynaptic membrane assembly (GO:0097105)4.27220796
16neurotransmitter secretion (GO:0007269)4.26698799
17glutamate receptor signaling pathway (GO:0007215)4.23521308
18regulation of synaptic vesicle transport (GO:1902803)4.20405873
19regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.17822491
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.15997604
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.13858595
22neuron-neuron synaptic transmission (GO:0007270)4.13338477
23protein localization to synapse (GO:0035418)4.12725490
24response to histamine (GO:0034776)4.12208120
25behavioral response to nicotine (GO:0035095)4.12020947
26locomotory exploration behavior (GO:0035641)4.05505377
27neurotransmitter transport (GO:0006836)4.00537971
28synaptic transmission, glutamatergic (GO:0035249)4.00271520
29synaptic vesicle maturation (GO:0016188)3.98714561
30catecholamine transport (GO:0051937)3.98158645
31mating behavior (GO:0007617)3.97779739
32presynaptic membrane organization (GO:0097090)3.92382450
33gamma-aminobutyric acid transport (GO:0015812)3.75740780
34regulation of neurotransmitter levels (GO:0001505)3.72474881
35neuromuscular process controlling posture (GO:0050884)3.71977329
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70793098
37prepulse inhibition (GO:0060134)3.70776571
38regulation of vesicle fusion (GO:0031338)3.70740842
39synaptic vesicle endocytosis (GO:0048488)3.69093355
40response to pheromone (GO:0019236)3.67966095
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.67152843
42neuron recognition (GO:0008038)3.66194783
43transmission of nerve impulse (GO:0019226)3.64143740
44righting reflex (GO:0060013)3.61131060
45postsynaptic membrane organization (GO:0001941)3.61118770
46neurotransmitter-gated ion channel clustering (GO:0072578)3.56977803
47neurotransmitter uptake (GO:0001504)3.55691423
48startle response (GO:0001964)3.55385016
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.54676872
50behavioral response to cocaine (GO:0048148)3.51892886
51regulation of dopamine metabolic process (GO:0042053)3.49458904
52regulation of catecholamine metabolic process (GO:0042069)3.49458904
53neuronal action potential propagation (GO:0019227)3.48831617
54G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.47395180
55exploration behavior (GO:0035640)3.46657447
56negative regulation of cytosolic calcium ion concentration (GO:0051481)3.43839802
57regulation of neuronal synaptic plasticity (GO:0048168)3.43749191
58L-fucose catabolic process (GO:0042355)3.42967224
59fucose catabolic process (GO:0019317)3.42967224
60L-fucose metabolic process (GO:0042354)3.42967224
61positive regulation of synapse assembly (GO:0051965)3.42392672
62synaptic vesicle docking involved in exocytosis (GO:0016081)3.42295861
63regulation of postsynaptic membrane potential (GO:0060078)3.42059423
64negative regulation of neurotransmitter transport (GO:0051589)3.41860266
65protein K11-linked deubiquitination (GO:0035871)3.39089709
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38317874
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.37085079
68regulation of glutamate secretion (GO:0014048)3.34758878
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33797636
70membrane hyperpolarization (GO:0060081)3.32894100
71regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32163328
72positive regulation of neurotransmitter transport (GO:0051590)3.32099265
73serotonin metabolic process (GO:0042428)3.30217662
74opioid receptor signaling pathway (GO:0038003)3.29985122
75cellular potassium ion homeostasis (GO:0030007)3.29824013
76proline transport (GO:0015824)3.26523030
77primary amino compound metabolic process (GO:1901160)3.21269358
78long-term memory (GO:0007616)3.20067481
79regulation of neurotransmitter secretion (GO:0046928)3.20064054
80response to auditory stimulus (GO:0010996)3.19990288
81regulation of synaptic transmission, GABAergic (GO:0032228)3.19762346
82auditory receptor cell stereocilium organization (GO:0060088)3.18566455
83long-term synaptic potentiation (GO:0060291)3.18147280
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.14588197
85membrane depolarization during action potential (GO:0086010)3.14387907
86protein localization to cilium (GO:0061512)3.14137033
87cerebellar granule cell differentiation (GO:0021707)3.12335229
88positive regulation of membrane potential (GO:0045838)3.10602289
89ATP hydrolysis coupled proton transport (GO:0015991)3.10057922
90energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10057922
91layer formation in cerebral cortex (GO:0021819)3.09369703
92regulation of neurotransmitter transport (GO:0051588)3.08518255
93synaptic transmission, dopaminergic (GO:0001963)3.08092618
94reflex (GO:0060004)3.07969289
95synaptic vesicle transport (GO:0048489)3.06834032
96establishment of synaptic vesicle localization (GO:0097480)3.06834032
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06638321
98behavioral response to ethanol (GO:0048149)3.06416870
99positive regulation of neurotransmitter secretion (GO:0001956)3.05317623
100cellular ketone body metabolic process (GO:0046950)3.04472378
101regulation of synapse structural plasticity (GO:0051823)3.04444066
102synapse assembly (GO:0007416)3.04256993
103detection of light stimulus involved in sensory perception (GO:0050962)3.04104143
104detection of light stimulus involved in visual perception (GO:0050908)3.04104143
105auditory behavior (GO:0031223)3.01401472
106adaptation of signaling pathway (GO:0023058)3.00657158
107neuronal action potential (GO:0019228)3.00609623
108C4-dicarboxylate transport (GO:0015740)3.00198993
109synaptic transmission (GO:0007268)2.98730858
110dendritic spine morphogenesis (GO:0060997)2.96481942
111positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95721490
112membrane depolarization (GO:0051899)2.94365600
113regulation of protein kinase A signaling (GO:0010738)2.93871459
114intraspecies interaction between organisms (GO:0051703)2.93595720
115social behavior (GO:0035176)2.93595720
116axonal fasciculation (GO:0007413)2.91407888
117transferrin transport (GO:0033572)2.90366958
118regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.90064445
119regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.90064445
120striatum development (GO:0021756)2.87864082
121ketone body metabolic process (GO:1902224)2.87793094
122positive regulation of synaptic transmission (GO:0050806)2.86946152
123indole-containing compound catabolic process (GO:0042436)2.85874967
124indolalkylamine catabolic process (GO:0046218)2.85874967
125tryptophan catabolic process (GO:0006569)2.85874967
126indolalkylamine metabolic process (GO:0006586)2.84006247
127platelet dense granule organization (GO:0060155)2.83452725
128kynurenine metabolic process (GO:0070189)2.82172273
129indole-containing compound metabolic process (GO:0042430)2.76901579
130response to amphetamine (GO:0001975)2.72558205
131detection of mechanical stimulus involved in sensory perception (GO:0050974)2.70335873
132retinal cone cell development (GO:0046549)2.66544518
133urinary tract smooth muscle contraction (GO:0014848)2.66519898
134neural tube formation (GO:0001841)2.65700914
135piRNA metabolic process (GO:0034587)2.64648790
136regulation of memory T cell differentiation (GO:0043380)2.63880895
137tachykinin receptor signaling pathway (GO:0007217)2.63662425
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62724729
139cellular potassium ion transport (GO:0071804)2.61281645
140potassium ion transmembrane transport (GO:0071805)2.61281645
141positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.60644717
142inner ear receptor stereocilium organization (GO:0060122)2.59149969
143calcium ion-dependent exocytosis (GO:0017156)2.59054984
144serotonin receptor signaling pathway (GO:0007210)2.57861883
145parturition (GO:0007567)2.56971049
146signal peptide processing (GO:0006465)2.55025689
147regulation of neurotransmitter uptake (GO:0051580)2.55013050
148DNA deamination (GO:0045006)2.54791811
149glycosphingolipid biosynthetic process (GO:0006688)2.54772245
150regulation of action potential (GO:0098900)2.54242331
151response to gravity (GO:0009629)2.54028660
152regulation of calcium ion-dependent exocytosis (GO:0017158)2.53715792
153synaptic transmission, cholinergic (GO:0007271)2.52336247
154potassium ion transport (GO:0006813)2.50048863
155NAD biosynthetic process (GO:0009435)2.50029487
156photoreceptor cell maintenance (GO:0045494)2.49140441
157nucleobase catabolic process (GO:0046113)2.47418850
158sleep (GO:0030431)2.46912147
159regulation of hexokinase activity (GO:1903299)2.46073742
160regulation of glucokinase activity (GO:0033131)2.46073742
161nonmotile primary cilium assembly (GO:0035058)2.45104327
162cAMP catabolic process (GO:0006198)2.45090313
163action potential (GO:0001508)2.40029226
164photoreceptor cell development (GO:0042461)2.38767545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.55783004
2GBX2_23144817_ChIP-Seq_PC3_Human4.20354588
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03747100
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95400497
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.89643020
6* TAF15_26573619_Chip-Seq_HEK293_Human2.78001750
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62588236
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59799841
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50015795
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45128204
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45128204
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.43977669
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.43341481
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40841663
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37865946
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.34842525
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.31873065
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30523082
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29426701
20* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15224184
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14829210
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11026773
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08117144
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06838486
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06660537
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02987158
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.01462885
28DROSHA_22980978_ChIP-Seq_HELA_Human2.00731440
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.90046263
30* P300_19829295_ChIP-Seq_ESCs_Human1.88810081
31SMAD4_21799915_ChIP-Seq_A2780_Human1.88646026
32AR_21572438_ChIP-Seq_LNCaP_Human1.87977127
33* REST_18959480_ChIP-ChIP_MESCs_Mouse1.87050790
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85367967
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68218995
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66995353
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.66427306
38* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64538728
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.61137765
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.61131026
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.56509554
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55533107
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.53009267
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.50897959
45FUS_26573619_Chip-Seq_HEK293_Human1.49096844
46ZNF274_21170338_ChIP-Seq_K562_Hela1.46136490
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42661055
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42612885
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41049996
50RNF2_27304074_Chip-Seq_NSC_Mouse1.40724582
51IGF1R_20145208_ChIP-Seq_DFB_Human1.40285927
52AR_25329375_ChIP-Seq_VCAP_Human1.40119885
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39958233
54PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39460774
55ER_23166858_ChIP-Seq_MCF-7_Human1.39142728
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38926719
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37994713
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37302962
59TP53_22573176_ChIP-Seq_HFKS_Human1.35014679
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34009155
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33646688
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33646688
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.32692165
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30146130
65STAT3_23295773_ChIP-Seq_U87_Human1.29756897
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27548474
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.27073178
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26627900
69SOX2_19829295_ChIP-Seq_ESCs_Human1.26362302
70NANOG_19829295_ChIP-Seq_ESCs_Human1.26362302
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26264795
72* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26014376
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24260585
74NANOG_18555785_Chip-Seq_ESCs_Mouse1.23549573
75* TCF4_22108803_ChIP-Seq_LS180_Human1.23330534
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22445893
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22373508
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21964654
79VDR_22108803_ChIP-Seq_LS180_Human1.21027863
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20801651
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.20768054
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18633292
83* TCF4_23295773_ChIP-Seq_U87_Human1.18003572
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.17018369
85RUNX2_22187159_ChIP-Seq_PCA_Human1.16066833
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.15062420
87JUN_21703547_ChIP-Seq_K562_Human1.13450290
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12269259
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09818353
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09007144
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.07297390
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06810646
93ERG_21242973_ChIP-ChIP_JURKAT_Human1.06601913
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05749541
95AR_19668381_ChIP-Seq_PC3_Human1.05645892
96BCAT_22108803_ChIP-Seq_LS180_Human1.05579820
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05272912
98E2F1_18555785_Chip-Seq_ESCs_Mouse1.04913293
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.04613133
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04535961
101* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04520539
102TP53_18474530_ChIP-ChIP_U2OS_Human1.04431586
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03713263
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03642315
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03354544
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03290506
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.03290506
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.02527619
109ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01874042
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01455224
111TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00565379
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00466237
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00392108
114P53_22387025_ChIP-Seq_ESCs_Mouse1.00264387
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.00200333
116EWS_26573619_Chip-Seq_HEK293_Human1.00125920
117CMYC_18555785_Chip-Seq_ESCs_Mouse0.99931609
118TP53_16413492_ChIP-PET_HCT116_Human0.98870990
119CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98720491
120AHR_22903824_ChIP-Seq_MCF-7_Human0.97550547
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97157215
122KDM2B_26808549_Chip-Seq_REH_Human0.96276815
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95682024
124YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95651717
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94830789
126CBP_20019798_ChIP-Seq_JUKART_Human0.93130368
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93130368
128SOX2_18555785_Chip-Seq_ESCs_Mouse0.93067010

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.77580834
2MP0004859_abnormal_synaptic_plasticity4.60576209
3* MP0003635_abnormal_synaptic_transmissio3.65155048
4MP0009046_muscle_twitch3.60595810
5* MP0009745_abnormal_behavioral_response3.33068623
6MP0005423_abnormal_somatic_nervous3.18131711
7* MP0002064_seizures3.16136013
8MP0002063_abnormal_learning/memory/cond2.86181534
9MP0006276_abnormal_autonomic_nervous2.85951174
10MP0001501_abnormal_sleep_pattern2.85889339
11MP0001486_abnormal_startle_reflex2.80150237
12MP0002572_abnormal_emotion/affect_behav2.77864318
13MP0001529_abnormal_vocalization2.76062950
14* MP0001968_abnormal_touch/_nociception2.68277070
15MP0004270_analgesia2.63597950
16MP0002272_abnormal_nervous_system2.63456517
17MP0001440_abnormal_grooming_behavior2.56305472
18MP0008877_abnormal_DNA_methylation2.55414774
19MP0001905_abnormal_dopamine_level2.39329265
20MP0002734_abnormal_mechanical_nocicepti2.37757724
21MP0000569_abnormal_digit_pigmentation2.36815515
22MP0003122_maternal_imprinting2.29500709
23MP0003195_calcinosis2.22470953
24* MP0002067_abnormal_sensory_capabilities2.15003305
25MP0005386_behavior/neurological_phenoty2.09424543
26MP0004924_abnormal_behavior2.09424543
27MP0002735_abnormal_chemical_nociception2.07872684
28MP0004142_abnormal_muscle_tone2.06861718
29* MP0002736_abnormal_nociception_after2.05042173
30MP0005645_abnormal_hypothalamus_physiol2.01998465
31MP0000372_irregular_coat_pigmentation1.94395138
32MP0001970_abnormal_pain_threshold1.92744988
33MP0005646_abnormal_pituitary_gland1.90178322
34MP0002733_abnormal_thermal_nociception1.89827800
35MP0002557_abnormal_social/conspecific_i1.87405096
36MP0001984_abnormal_olfaction1.77362759
37MP0005551_abnormal_eye_electrophysiolog1.73798649
38MP0002822_catalepsy1.71448856
39MP0004147_increased_porphyrin_level1.69543762
40MP0002184_abnormal_innervation1.63357688
41MP0003787_abnormal_imprinting1.59189367
42MP0004043_abnormal_pH_regulation1.58789928
43MP0008875_abnormal_xenobiotic_pharmacok1.52232429
44MP0008569_lethality_at_weaning1.51963256
45MP0001502_abnormal_circadian_rhythm1.51390637
46MP0004742_abnormal_vestibular_system1.51289442
47MP0001188_hyperpigmentation1.51282972
48MP0000778_abnormal_nervous_system1.49996009
49MP0000427_abnormal_hair_cycle1.39190932
50MP0003011_delayed_dark_adaptation1.39096579
51MP0002066_abnormal_motor_capabilities/c1.34953191
52MP0000383_abnormal_hair_follicle1.31069254
53MP0002882_abnormal_neuron_morphology1.27201753
54MP0008872_abnormal_physiological_respon1.25312491
55MP0002909_abnormal_adrenal_gland1.24763017
56MP0003879_abnormal_hair_cell1.20627588
57MP0003878_abnormal_ear_physiology1.19500707
58MP0005377_hearing/vestibular/ear_phenot1.19500707
59MP0000955_abnormal_spinal_cord1.18969291
60MP0004858_abnormal_nervous_system1.18360006
61MP0004811_abnormal_neuron_physiology1.15159911
62MP0002876_abnormal_thyroid_physiology1.14681843
63MP0002229_neurodegeneration1.12046507
64MP0009780_abnormal_chondrocyte_physiolo1.11987570
65MP0003329_amyloid_beta_deposits1.09120858
66MP0003690_abnormal_glial_cell1.08907127
67MP0006072_abnormal_retinal_apoptosis1.08781484
68MP0003633_abnormal_nervous_system1.07953893
69MP0004885_abnormal_endolymph1.06579779
70MP0010386_abnormal_urinary_bladder1.06548991
71MP0001919_abnormal_reproductive_system1.06169313
72MP0001664_abnormal_digestion1.03335436
73MP0003646_muscle_fatigue1.02834753
74MP0001963_abnormal_hearing_physiology1.01237447
75MP0005410_abnormal_fertilization1.01215829
76MP0000631_abnormal_neuroendocrine_gland0.98989644
77MP0005535_abnormal_body_temperature0.98491256
78MP0003631_nervous_system_phenotype0.95973296
79MP0000751_myopathy0.95407705
80MP0005171_absent_coat_pigmentation0.94865163
81MP0005075_abnormal_melanosome_morpholog0.94148260
82MP0005174_abnormal_tail_pigmentation0.93372012
83MP0002837_dystrophic_cardiac_calcinosis0.92524740
84MP0004145_abnormal_muscle_electrophysio0.91086459
85MP0003121_genomic_imprinting0.90852259
86MP0002090_abnormal_vision0.90781373
87* MP0005253_abnormal_eye_physiology0.89862004
88MP0002069_abnormal_eating/drinking_beha0.88349473
89MP0002752_abnormal_somatic_nervous0.87242136
90MP0001177_atelectasis0.87150678
91MP0003634_abnormal_glial_cell0.87084128
92MP0005389_reproductive_system_phenotype0.86703463
93MP0004133_heterotaxia0.86271291
94MP0002152_abnormal_brain_morphology0.84897485
95MP0005409_darkened_coat_color0.84633728
96MP0000920_abnormal_myelination0.82971141
97MP0005394_taste/olfaction_phenotype0.82542638
98MP0005499_abnormal_olfactory_system0.82542638
99MP0002102_abnormal_ear_morphology0.82407919
100MP0002693_abnormal_pancreas_physiology0.82270189
101MP0002638_abnormal_pupillary_reflex0.82171552
102MP0005187_abnormal_penis_morphology0.81667881
103MP0008874_decreased_physiological_sensi0.81279722
104MP0005379_endocrine/exocrine_gland_phen0.80770175
105MP0003123_paternal_imprinting0.79549571
106MP0008995_early_reproductive_senescence0.79322419
107MP0002928_abnormal_bile_duct0.78207740
108MP0005167_abnormal_blood-brain_barrier0.74820592
109MP0001765_abnormal_ion_homeostasis0.73296848
110MP0003283_abnormal_digestive_organ0.72210874
111MP0002938_white_spotting0.71110734
112MP0003632_abnormal_nervous_system0.70694986
113MP0002160_abnormal_reproductive_system0.69880446
114MP0000230_abnormal_systemic_arterial0.69861413
115MP0002234_abnormal_pharynx_morphology0.67857316
116MP0001986_abnormal_taste_sensitivity0.67326814
117MP0000026_abnormal_inner_ear0.66424469
118MP0000013_abnormal_adipose_tissue0.66277188
119MP0004085_abnormal_heartbeat0.65283968
120MP0000639_abnormal_adrenal_gland0.64793994
121MP0001943_abnormal_respiration0.57918562
122MP0002163_abnormal_gland_morphology0.57081020
123MP0005195_abnormal_posterior_eye0.53894886
124MP0004215_abnormal_myocardial_fiber0.52364332
125MP0000538_abnormal_urinary_bladder0.52067153
126MP0005623_abnormal_meninges_morphology0.49247443
127MP0003136_yellow_coat_color0.47582424
128MP0002751_abnormal_autonomic_nervous0.47510415
129MP0001485_abnormal_pinna_reflex0.47184469
130MP0008004_abnormal_stomach_pH0.46776185

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.53467566
2Limb dystonia (HP:0002451)6.12134409
3Focal seizures (HP:0007359)5.24808756
4Visual hallucinations (HP:0002367)5.09655898
5Atonic seizures (HP:0010819)4.67678316
6Epileptic encephalopathy (HP:0200134)4.66119633
7Febrile seizures (HP:0002373)4.62635307
8Myokymia (HP:0002411)4.62179414
9Absence seizures (HP:0002121)4.39832245
10Generalized tonic-clonic seizures (HP:0002069)4.02633189
11Dialeptic seizures (HP:0011146)3.95356479
12Pancreatic cysts (HP:0001737)3.94381567
13Progressive cerebellar ataxia (HP:0002073)3.83969835
14Pancreatic fibrosis (HP:0100732)3.77062744
15Pheochromocytoma (HP:0002666)3.71955404
16Neuroendocrine neoplasm (HP:0100634)3.43777258
17True hermaphroditism (HP:0010459)3.37322743
18Broad-based gait (HP:0002136)3.26608475
19Abnormality of midbrain morphology (HP:0002418)3.19650264
20Molar tooth sign on MRI (HP:0002419)3.19650264
21Polyphagia (HP:0002591)3.16803278
22Decreased circulating renin level (HP:0003351)3.15117345
23Abnormal eating behavior (HP:0100738)3.11631065
24Type II lissencephaly (HP:0007260)3.09207497
25Failure to thrive in infancy (HP:0001531)3.08797763
26Progressive inability to walk (HP:0002505)3.07596496
27Hyperventilation (HP:0002883)3.02240751
28Nephronophthisis (HP:0000090)2.97673053
29Abnormality of the renal cortex (HP:0011035)2.96900333
30Hypokalemic alkalosis (HP:0001949)2.87491771
31Supranuclear gaze palsy (HP:0000605)2.86776729
32Abnormal hair whorl (HP:0010721)2.85807571
33Anxiety (HP:0000739)2.85612998
34Gait imbalance (HP:0002141)2.78656885
35Attenuation of retinal blood vessels (HP:0007843)2.75151884
36Truncal ataxia (HP:0002078)2.69720460
37Abnormal rod and cone electroretinograms (HP:0008323)2.66899884
38Excessive salivation (HP:0003781)2.66673270
39Drooling (HP:0002307)2.66673270
40Acute necrotizing encephalopathy (HP:0006965)2.65881897
41Dysdiadochokinesis (HP:0002075)2.65751148
42Abnormality of the renal medulla (HP:0100957)2.62381239
43Blue irides (HP:0000635)2.61488306
44Genetic anticipation (HP:0003743)2.60085501
45Abolished electroretinogram (ERG) (HP:0000550)2.59392614
46Vaginal atresia (HP:0000148)2.58502921
47Hypothermia (HP:0002045)2.57985282
48Hypoventilation (HP:0002791)2.57818599
49Polydipsia (HP:0001959)2.56839626
50Abnormal drinking behavior (HP:0030082)2.56839626
51Abnormality of binocular vision (HP:0011514)2.55989525
52Diplopia (HP:0000651)2.55989525
53Genital tract atresia (HP:0001827)2.55666350
54Fetal akinesia sequence (HP:0001989)2.55054685
55Cerebral inclusion bodies (HP:0100314)2.54737426
56Gaze-evoked nystagmus (HP:0000640)2.53203076
57Cystic liver disease (HP:0006706)2.51316045
58Abnormal mitochondria in muscle tissue (HP:0008316)2.50741424
59Progressive macrocephaly (HP:0004481)2.50682666
60Increased corneal curvature (HP:0100692)2.50281084
61Keratoconus (HP:0000563)2.50281084
62Congenital primary aphakia (HP:0007707)2.50253576
63Renal cortical cysts (HP:0000803)2.47243256
64Amblyopia (HP:0000646)2.41497818
65Poor suck (HP:0002033)2.39806574
66Medial flaring of the eyebrow (HP:0010747)2.39344384
67Chronic hepatic failure (HP:0100626)2.38817180
68Abnormal pupillary function (HP:0007686)2.38235410
69Nephrogenic diabetes insipidus (HP:0009806)2.37366181
70Bradykinesia (HP:0002067)2.37079292
71Abnormality of macular pigmentation (HP:0008002)2.37073673
72Inability to walk (HP:0002540)2.35203663
73Esotropia (HP:0000565)2.35041668
74Hemiparesis (HP:0001269)2.34414534
75Depression (HP:0000716)2.33303032
76Dysmetria (HP:0001310)2.33143794
77Congenital stationary night blindness (HP:0007642)2.32974885
78Neurofibrillary tangles (HP:0002185)2.29289451
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.22992659
80Absent/shortened dynein arms (HP:0200106)2.22992659
81Retinal dysplasia (HP:0007973)2.22500469
82Delayed gross motor development (HP:0002194)2.21947823
83Mutism (HP:0002300)2.20283845
84Postural instability (HP:0002172)2.19988235
85Clumsiness (HP:0002312)2.17695312
86Impaired vibration sensation in the lower limbs (HP:0002166)2.17022163
87Decreased central vision (HP:0007663)2.14575109
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13814562
89Psychosis (HP:0000709)2.13588820
90Mitochondrial inheritance (HP:0001427)2.13554958
91Action tremor (HP:0002345)2.11886504
92Ankle clonus (HP:0011448)2.11169574
93Sclerocornea (HP:0000647)2.10369336
94Abnormality of renin-angiotensin system (HP:0000847)2.10170888
95Abnormality of alanine metabolism (HP:0010916)2.09729358
96Hyperalaninemia (HP:0003348)2.09729358
97Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09729358
98Polyuria (HP:0000103)2.07741745
99Metabolic alkalosis (HP:0200114)2.07268159
100Congenital sensorineural hearing impairment (HP:0008527)2.06936177
101Agitation (HP:0000713)2.06806102
102Status epilepticus (HP:0002133)2.06739730
103Abnormal ciliary motility (HP:0012262)2.05425568
104Pendular nystagmus (HP:0012043)2.05039919
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.04064557
106Specific learning disability (HP:0001328)2.03023113
107Abnormality of the labia minora (HP:0012880)2.00952183
108Epileptiform EEG discharges (HP:0011182)2.00897458
109Optic disc pallor (HP:0000543)1.99762252
110Narrow nasal bridge (HP:0000446)1.99352172
111Hyperaldosteronism (HP:0000859)1.98771328
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.98204083
113Scanning speech (HP:0002168)1.97712690
114Abnormality of salivation (HP:0100755)1.96846683
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.95903496
116Poor eye contact (HP:0000817)1.94756680
117Rigidity (HP:0002063)1.94300170
118Large for gestational age (HP:0001520)1.93762812
119Morphological abnormality of the pyramidal tract (HP:0002062)1.93372481
120Lissencephaly (HP:0001339)1.93222590
121Diminished movement (HP:0002374)1.91271510
122Bony spicule pigmentary retinopathy (HP:0007737)1.91017249
123Hemiplegia (HP:0002301)1.90829073
124Hypokinesia (HP:0002375)1.90429647
125Urinary bladder sphincter dysfunction (HP:0002839)1.90037699
126Spastic gait (HP:0002064)1.89771229
127Abnormality of the corticospinal tract (HP:0002492)1.88564304
128Generalized myoclonic seizures (HP:0002123)1.88250832
129Stomach cancer (HP:0012126)1.87750139
130EEG with generalized epileptiform discharges (HP:0011198)1.87500165
131Protruding tongue (HP:0010808)1.86879253
132Cerebral hemorrhage (HP:0001342)1.86657825
133Postural tremor (HP:0002174)1.83818207
134Cerebellar dysplasia (HP:0007033)1.82863189
135Absent speech (HP:0001344)1.82244266
136Congenital hepatic fibrosis (HP:0002612)1.81861783
137Central scotoma (HP:0000603)1.81327098
138Aplasia/hypoplasia of the uterus (HP:0008684)1.80804023
139Abnormal social behavior (HP:0012433)1.79840805
140Impaired social interactions (HP:0000735)1.79840805
141Torticollis (HP:0000473)1.79236610
142Facial shape deformation (HP:0011334)1.79125668
143Potter facies (HP:0002009)1.79125668
144Ketoacidosis (HP:0001993)1.78448096
145Intestinal atresia (HP:0011100)1.78084219
146Hypsarrhythmia (HP:0002521)1.76983171
147Hypomagnesemia (HP:0002917)1.76605141
148Bile duct proliferation (HP:0001408)1.76343049
149Abnormal biliary tract physiology (HP:0012439)1.76343049
150Alkalosis (HP:0001948)1.76033851
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.74676932
152Hypoplasia of the fovea (HP:0007750)1.74676932
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73541543
154Furrowed tongue (HP:0000221)1.72697195
155Impaired smooth pursuit (HP:0007772)1.72366217
156Optic nerve hypoplasia (HP:0000609)1.68754432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.73945690
2NTRK34.19551560
3MAP3K123.84782955
4CASK3.83442458
5MAP3K43.14567138
6MAP2K73.02101404
7MAP3K92.85154793
8EPHA42.64735772
9MAP4K22.53171861
10TAOK32.44212358
11MARK12.40175825
12TNIK2.34055535
13MAP2K42.25831936
14NTRK22.16586681
15MINK12.15363336
16PNCK2.10972950
17TXK2.10179607
18PLK22.00011082
19ACVR1B1.97632133
20GRK51.96459459
21MAPK131.90799821
22MAPKAPK51.77922354
23INSRR1.69800108
24ZAK1.66148254
25GRK11.62015115
26ADRBK21.60753274
27CDK191.56697806
28SIK21.55102783
29NUAK11.54100915
30ARAF1.49388090
31PIK3CA1.48254249
32CAMK2A1.41671339
33DAPK21.38755834
34FES1.37601016
35GRK71.34616671
36CDK51.32013731
37TLK11.31081347
38NTRK11.30230831
39AKT31.28257346
40PRKCG1.27835196
41OXSR11.26245060
42PAK61.23841361
43MAP3K131.18662399
44CAMKK21.17391446
45FGR1.17151514
46RIPK41.15993258
47TNK21.14697896
48CAMK2B1.13116966
49CSNK1G21.09064589
50UHMK11.06896923
51SGK2231.03102448
52SGK4941.03102448
53DAPK11.02949196
54CAMKK11.02637252
55PRPF4B0.97371395
56CAMK2D0.95716018
57SIK30.93969541
58KSR20.93449117
59SGK20.91690823
60KSR10.90532097
61PRKCH0.88950313
62CAMK1G0.85899255
63TRIM280.84153705
64CAMK2G0.83938304
65ADRBK10.83503694
66CDK180.82750004
67CSNK1G30.81691579
68PHKG10.81546747
69PHKG20.81546747
70PRKD30.80750727
71ERBB30.80146817
72CDK150.79777582
73CDK140.79019720
74DYRK20.75707423
75MAP2K20.74673421
76DYRK1A0.73447877
77MKNK20.72837015
78PAK30.72689990
79PRKCE0.72488720
80CAMK10.72271706
81BMPR20.70024131
82SGK10.69381824
83NME10.69139646
84CDK11A0.66203199
85STK390.63853263
86STK110.62123137
87STK380.61440733
88BRAF0.60666390
89PINK10.60354418
90PKN10.60346945
91PTK2B0.59789140
92LATS20.58734591
93WNK30.58501323
94FER0.58165984
95BCR0.57650268
96BMPR1B0.57042262
97FGFR20.56443571
98BCKDK0.55851442
99RET0.55715811
100CDK30.53891977
101GRK60.53881091
102STK38L0.53489926
103CSNK1A1L0.50907920
104CSNK1G10.50200300
105NEK60.49216214
106SGK30.48213299
107MAP2K10.47357132
108WNK10.46631426
109LMTK20.46546741
110PRKCZ0.46512727
111MAP3K20.45124093
112CHUK0.44788950
113CSNK1A10.44741624
114PRKACA0.44645009
115PRKG10.43023235
116RPS6KA30.41396239
117PRKCA0.41310473
118WNK40.40326673
119PRKCQ0.40141580
120CSNK1D0.39906511
121FYN0.39638850
122LIMK10.39130172
123CAMK1D0.38878268
124ROCK20.38811576
125PDK20.38685864
126CDK80.38147256
127SCYL20.37413590
128EIF2AK20.37374385
129CCNB10.36870545
130MUSK0.36353263
131PRKCB0.36259096
132PLK40.35163735
133IKBKB0.35111755
134EIF2AK30.34827638
135CAMK40.34426018
136MAP2K60.34384963
137IGF1R0.34099363
138MST40.33731179

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.78891465
2Synaptic vesicle cycle_Homo sapiens_hsa047213.85248722
3GABAergic synapse_Homo sapiens_hsa047272.97636467
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88713969
5Collecting duct acid secretion_Homo sapiens_hsa049662.76753937
6Morphine addiction_Homo sapiens_hsa050322.64871587
7Amphetamine addiction_Homo sapiens_hsa050312.55720829
8Cocaine addiction_Homo sapiens_hsa050302.44770782
9Olfactory transduction_Homo sapiens_hsa047402.43457175
10Glutamatergic synapse_Homo sapiens_hsa047242.41276483
11Circadian entrainment_Homo sapiens_hsa047132.40800174
12Oxidative phosphorylation_Homo sapiens_hsa001902.39545733
13Dopaminergic synapse_Homo sapiens_hsa047282.12785080
14Serotonergic synapse_Homo sapiens_hsa047262.12442725
15Long-term potentiation_Homo sapiens_hsa047202.04035105
16Taste transduction_Homo sapiens_hsa047421.99414547
17Parkinsons disease_Homo sapiens_hsa050121.90508030
18Phototransduction_Homo sapiens_hsa047441.89965813
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85804525
20Salivary secretion_Homo sapiens_hsa049701.85056667
21* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.84113941
22Linoleic acid metabolism_Homo sapiens_hsa005911.83208382
23Insulin secretion_Homo sapiens_hsa049111.75895825
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75273728
25Cholinergic synapse_Homo sapiens_hsa047251.70001574
26Vibrio cholerae infection_Homo sapiens_hsa051101.69613500
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.68401606
28Renin secretion_Homo sapiens_hsa049241.64118586
29Long-term depression_Homo sapiens_hsa047301.60111085
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56446810
31Alzheimers disease_Homo sapiens_hsa050101.55573099
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54858538
33Calcium signaling pathway_Homo sapiens_hsa040201.54485225
34Gastric acid secretion_Homo sapiens_hsa049711.53471209
35Cardiac muscle contraction_Homo sapiens_hsa042601.45554112
36Protein export_Homo sapiens_hsa030601.35027360
37Tryptophan metabolism_Homo sapiens_hsa003801.33513076
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32002535
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31403606
40Oxytocin signaling pathway_Homo sapiens_hsa049211.28138010
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24476848
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23856100
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.21289735
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19652945
45Caffeine metabolism_Homo sapiens_hsa002321.19334692
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17359320
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14638184
48ABC transporters_Homo sapiens_hsa020101.12469451
49Huntingtons disease_Homo sapiens_hsa050161.11880599
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11053470
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09572440
52Gap junction_Homo sapiens_hsa045401.07375900
53GnRH signaling pathway_Homo sapiens_hsa049121.05955820
54Rheumatoid arthritis_Homo sapiens_hsa053231.03387999
55Selenocompound metabolism_Homo sapiens_hsa004501.03085598
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99768507
57cAMP signaling pathway_Homo sapiens_hsa040240.97425970
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89603777
59Basal transcription factors_Homo sapiens_hsa030220.87762013
60Propanoate metabolism_Homo sapiens_hsa006400.85691686
61Type I diabetes mellitus_Homo sapiens_hsa049400.80340531
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78218465
63Axon guidance_Homo sapiens_hsa043600.77460918
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.76826977
65Type II diabetes mellitus_Homo sapiens_hsa049300.76825136
66beta-Alanine metabolism_Homo sapiens_hsa004100.76728987
67Estrogen signaling pathway_Homo sapiens_hsa049150.75286876
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73861476
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72842216
70Regulation of autophagy_Homo sapiens_hsa041400.72526215
71Arachidonic acid metabolism_Homo sapiens_hsa005900.72356617
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71402421
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.70045444
74Melanogenesis_Homo sapiens_hsa049160.69745446
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67901873
76Peroxisome_Homo sapiens_hsa041460.67450271
77Nitrogen metabolism_Homo sapiens_hsa009100.66310895
78ErbB signaling pathway_Homo sapiens_hsa040120.62641527
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62304002
80RNA polymerase_Homo sapiens_hsa030200.62070924
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61111135
82Histidine metabolism_Homo sapiens_hsa003400.60793913
83Alcoholism_Homo sapiens_hsa050340.59247245
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58838962
85Pancreatic secretion_Homo sapiens_hsa049720.58298049
86Thyroid hormone synthesis_Homo sapiens_hsa049180.56706499
87Dilated cardiomyopathy_Homo sapiens_hsa054140.55436148
88Homologous recombination_Homo sapiens_hsa034400.55141589
89Phagosome_Homo sapiens_hsa041450.54437881
90Chemical carcinogenesis_Homo sapiens_hsa052040.53260311
91Mineral absorption_Homo sapiens_hsa049780.52454420
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.51617694
93MAPK signaling pathway_Homo sapiens_hsa040100.50683511
94Fatty acid biosynthesis_Homo sapiens_hsa000610.49730018
95Phenylalanine metabolism_Homo sapiens_hsa003600.49410745
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49142097
97Glycerolipid metabolism_Homo sapiens_hsa005610.48817293
98African trypanosomiasis_Homo sapiens_hsa051430.48361348
99Dorso-ventral axis formation_Homo sapiens_hsa043200.47799960
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46388201
101Glioma_Homo sapiens_hsa052140.44466862
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44282122
103Retinol metabolism_Homo sapiens_hsa008300.43313908
104Ovarian steroidogenesis_Homo sapiens_hsa049130.42664830
105Ras signaling pathway_Homo sapiens_hsa040140.38055826
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37731264
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.37648761
108Fatty acid metabolism_Homo sapiens_hsa012120.37627491
109Prion diseases_Homo sapiens_hsa050200.35722180
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.35258365
111Tyrosine metabolism_Homo sapiens_hsa003500.34599442
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33683718
113Purine metabolism_Homo sapiens_hsa002300.33054138
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32999173
115Metabolic pathways_Homo sapiens_hsa011000.32962226
116Inositol phosphate metabolism_Homo sapiens_hsa005620.32571245
117Oocyte meiosis_Homo sapiens_hsa041140.31969993
118Circadian rhythm_Homo sapiens_hsa047100.31546028
119Fanconi anemia pathway_Homo sapiens_hsa034600.30219146
120Glucagon signaling pathway_Homo sapiens_hsa049220.29839090
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27649896
122Primary immunodeficiency_Homo sapiens_hsa053400.27254511
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26795822
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26343328
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25688749
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25688042
127Choline metabolism in cancer_Homo sapiens_hsa052310.25662735
128Sulfur metabolism_Homo sapiens_hsa009200.25217773
129Ether lipid metabolism_Homo sapiens_hsa005650.24616202
130Bile secretion_Homo sapiens_hsa049760.24319786
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.21896660
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20539325
133Rap1 signaling pathway_Homo sapiens_hsa040150.17926159
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17437639
135Butanoate metabolism_Homo sapiens_hsa006500.16363251
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.16025787
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14776646
138Chemokine signaling pathway_Homo sapiens_hsa040620.12399845
139Wnt signaling pathway_Homo sapiens_hsa043100.12105153

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