GLOD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a glyoxalase domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.29221216
2drug catabolic process (GO:0042737)6.64742393
3regulation of bile acid biosynthetic process (GO:0070857)6.29139505
4drug transmembrane transport (GO:0006855)5.79398325
5intestinal cholesterol absorption (GO:0030299)5.74120219
6exogenous drug catabolic process (GO:0042738)5.65773747
7intestinal epithelial cell development (GO:0060576)5.52974098
8drug transport (GO:0015893)5.45959692
9angiotensin maturation (GO:0002003)5.44956966
10flavonoid metabolic process (GO:0009812)5.12664041
11protein neddylation (GO:0045116)4.93871884
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.87282954
13L-phenylalanine metabolic process (GO:0006558)4.87282954
14thrombin receptor signaling pathway (GO:0070493)4.83850302
15modified amino acid transport (GO:0072337)4.77298288
16fusion of sperm to egg plasma membrane (GO:0007342)4.69887192
17urate metabolic process (GO:0046415)4.65407567
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.58811878
19L-phenylalanine catabolic process (GO:0006559)4.58811878
20UDP-N-acetylglucosamine metabolic process (GO:0006047)4.45135068
213-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.42662559
22purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.42662559
23bile acid and bile salt transport (GO:0015721)4.40563254
24calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.39677796
25phosphate ion transport (GO:0006817)4.39532929
26bundle of His cell to Purkinje myocyte communication (GO:0086069)4.37322038
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36673829
28sulfation (GO:0051923)4.26023390
29digestive system process (GO:0022600)4.25733673
30xenobiotic catabolic process (GO:0042178)4.25095016
31vitamin A metabolic process (GO:0006776)4.22638989
32phosphate ion transmembrane transport (GO:0035435)4.15022440
33transepithelial transport (GO:0070633)4.12162569
34aminoglycoside antibiotic metabolic process (GO:0030647)4.11522612
35cellular ketone body metabolic process (GO:0046950)4.05442962
36sulfate transmembrane transport (GO:1902358)4.02963042
37high-density lipoprotein particle remodeling (GO:0034375)3.99797152
38regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.98058502
39homocysteine metabolic process (GO:0050667)3.97375720
40sulfur compound transport (GO:0072348)3.92018131
41proline metabolic process (GO:0006560)3.88192594
42actin filament depolymerization (GO:0030042)3.85216194
43blood coagulation, intrinsic pathway (GO:0007597)3.81915980
44reverse cholesterol transport (GO:0043691)3.77249344
45cysteine metabolic process (GO:0006534)3.75163006
46negative regulation of keratinocyte proliferation (GO:0010839)3.73741132
47peptide catabolic process (GO:0043171)3.73327369
48negative regulation of sterol transport (GO:0032372)3.72223082
49negative regulation of cholesterol transport (GO:0032375)3.72223082
50glutathione derivative biosynthetic process (GO:1901687)3.71618050
51glutathione derivative metabolic process (GO:1901685)3.71618050
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.65976509
53digestion (GO:0007586)3.62723980
54regulation of integrin activation (GO:0033623)3.60955850
55drug metabolic process (GO:0017144)3.60882677
56regulation of protein glycosylation (GO:0060049)3.55274649
57GDP-mannose metabolic process (GO:0019673)3.54475426
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.54021340
59phosphatidylinositol acyl-chain remodeling (GO:0036149)3.51299057
60ketone body metabolic process (GO:1902224)3.51089230
61renal absorption (GO:0070293)3.49930901
62diacylglycerol metabolic process (GO:0046339)3.49065941
63maintenance of gastrointestinal epithelium (GO:0030277)3.47070582
64inositol phosphate catabolic process (GO:0071545)3.46491887
65sulfate transport (GO:0008272)3.43775660
66phenylpropanoid metabolic process (GO:0009698)3.42742802
67phospholipid homeostasis (GO:0055091)3.42571764
68vitamin transport (GO:0051180)3.41120926
69regulation of acrosome reaction (GO:0060046)3.39638615
70excretion (GO:0007588)3.39270175
71bicarbonate transport (GO:0015701)3.39050965
72dopamine transport (GO:0015872)3.38526038
73glyoxylate metabolic process (GO:0046487)3.38169619
74NADH metabolic process (GO:0006734)3.36776636
75virion attachment to host cell (GO:0019062)3.35085418
76adhesion of symbiont to host cell (GO:0044650)3.35085418
77plasma membrane fusion (GO:0045026)3.34714964
78positive regulation of triglyceride lipase activity (GO:0061365)3.34423817
79positive regulation of lipoprotein lipase activity (GO:0051006)3.34423817
80fructose metabolic process (GO:0006000)3.33603910
81lysine metabolic process (GO:0006553)3.31783867
82lysine catabolic process (GO:0006554)3.31783867
83quaternary ammonium group transport (GO:0015697)3.29818738
84negative regulation of appetite (GO:0032099)3.28297965
85negative regulation of response to food (GO:0032096)3.28297965
86proline biosynthetic process (GO:0006561)3.28055876
87polyol transport (GO:0015791)3.27638977
88aromatic amino acid family catabolic process (GO:0009074)3.26840150
89regulation of platelet activation (GO:0010543)3.26812487
90oxidative demethylation (GO:0070989)3.22091886
91nucleotide-sugar biosynthetic process (GO:0009226)3.20097813
92organelle membrane fusion (GO:0090174)3.19862413
93organic cation transport (GO:0015695)3.18430874
94phosphorylated carbohydrate dephosphorylation (GO:0046838)3.17110865
95inositol phosphate dephosphorylation (GO:0046855)3.17110865
96nonribosomal peptide biosynthetic process (GO:0019184)3.16965492
97energy coupled proton transport, down electrochemical gradient (GO:0015985)3.16946329
98ATP synthesis coupled proton transport (GO:0015986)3.16946329
99low-density lipoprotein particle remodeling (GO:0034374)3.16884504
100phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.13213497
101sterol homeostasis (GO:0055092)3.12282986
102negative regulation of execution phase of apoptosis (GO:1900118)3.08655618
103oligosaccharide catabolic process (GO:0009313)3.08141663
104retinol metabolic process (GO:0042572)3.08110419
105glutathione biosynthetic process (GO:0006750)3.07958998
106cholesterol homeostasis (GO:0042632)3.07883643
107glucose 6-phosphate metabolic process (GO:0051156)3.07086141
108positive regulation of pseudopodium assembly (GO:0031274)3.06886933
109regulation of triglyceride catabolic process (GO:0010896)3.06781338
110regulation of memory T cell differentiation (GO:0043380)3.05813199
111polyol catabolic process (GO:0046174)3.05787277
112ribosomal large subunit biogenesis (GO:0042273)3.05497420
113negative regulation of heart rate (GO:0010459)3.04279971
114viral transcription (GO:0019083)3.04213051
115lipoprotein metabolic process (GO:0042157)3.03605099
116positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.03292611
117short-chain fatty acid metabolic process (GO:0046459)3.02169191
118autophagic vacuole fusion (GO:0000046)2.98549886
119regulation of chemokine secretion (GO:0090196)2.97449357
120regulation of oxidative phosphorylation (GO:0002082)2.97344794
121respiratory electron transport chain (GO:0022904)2.96481187
122regulation of respiratory burst (GO:0060263)2.96019982
123triglyceride homeostasis (GO:0070328)2.95459412
124acylglycerol homeostasis (GO:0055090)2.95459412
125piRNA metabolic process (GO:0034587)2.93113273
126mucosal immune response (GO:0002385)2.92739780
127amino-acid betaine transport (GO:0015838)2.92514039
128carnitine transport (GO:0015879)2.92514039
129cellular response to vitamin D (GO:0071305)2.92465794
130galactose catabolic process (GO:0019388)2.92341579
131vitamin D metabolic process (GO:0042359)2.91723605
132sulfur amino acid catabolic process (GO:0000098)2.91045203
133hormone catabolic process (GO:0042447)2.90421862
134positive regulation of cAMP-mediated signaling (GO:0043950)2.89826329
135translational termination (GO:0006415)2.89244356
136O-glycan processing (GO:0016266)2.89023695
137desmosome organization (GO:0002934)2.88917522
138electron transport chain (GO:0022900)2.88272553
139tyrosine metabolic process (GO:0006570)2.86718864
140phospholipid scrambling (GO:0017121)2.84858036
141response to phenylpropanoid (GO:0080184)2.83886213
142regulation of integrin-mediated signaling pathway (GO:2001044)2.82680365
143regulation of Golgi to plasma membrane protein transport (GO:0042996)2.82408750
144positive regulation of digestive system process (GO:0060456)2.81979507
145regulation of response to food (GO:0032095)2.77441772
146regulation of lipoprotein metabolic process (GO:0050746)2.77053699
147carnitine metabolic process (GO:0009437)2.74843109
148regulation of cilium movement (GO:0003352)2.73694711
149response to hydroperoxide (GO:0033194)2.71555928
150respiratory chain complex IV assembly (GO:0008535)2.64722390
151endosome to melanosome transport (GO:0035646)2.64452682
152endosome to pigment granule transport (GO:0043485)2.64452682
153signal peptide processing (GO:0006465)2.63458867
154centriole replication (GO:0007099)2.62897537
155regulation of acyl-CoA biosynthetic process (GO:0050812)2.62405090
156amino-acid betaine metabolic process (GO:0006577)2.62165856
157protein-lipid complex remodeling (GO:0034368)2.60627690
158macromolecular complex remodeling (GO:0034367)2.60627690
159plasma lipoprotein particle remodeling (GO:0034369)2.60627690
160positive regulation of cellular amine metabolic process (GO:0033240)2.60582462
161S-adenosylmethionine metabolic process (GO:0046500)2.60033563
162nitric oxide mediated signal transduction (GO:0007263)2.58260248
163single strand break repair (GO:0000012)2.57955077
164insulin secretion (GO:0030073)2.57510678
165peptide hormone processing (GO:0016486)2.56674846
166peroxisome fission (GO:0016559)2.54054284
167positive regulation of hemostasis (GO:1900048)2.52709391
168positive regulation of blood coagulation (GO:0030194)2.52709391
169cellular biogenic amine catabolic process (GO:0042402)2.52597111
170amine catabolic process (GO:0009310)2.52597111
171water-soluble vitamin biosynthetic process (GO:0042364)2.50970133
172cellular glucuronidation (GO:0052695)2.50949949
173lactate metabolic process (GO:0006089)2.50931516
174regulation of clathrin-mediated endocytosis (GO:2000369)2.46668942
175bile acid biosynthetic process (GO:0006699)2.46237398
176regulation of appetite (GO:0032098)2.44042514
177platelet dense granule organization (GO:0060155)2.43910147
178replication fork processing (GO:0031297)2.41633617
179glycerophospholipid catabolic process (GO:0046475)2.41241915
180uronic acid metabolic process (GO:0006063)2.40363297
181glucuronate metabolic process (GO:0019585)2.40363297
182aromatic amino acid family metabolic process (GO:0009072)2.38132467
183positive regulation of coagulation (GO:0050820)2.37880669
184monoamine transport (GO:0015844)2.36242414
185epoxygenase P450 pathway (GO:0019373)2.35357034
186platelet degranulation (GO:0002576)2.35336192
187negative regulation of norepinephrine secretion (GO:0010700)2.34974954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.40235675
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.81177202
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.46929698
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.85558605
5HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.84424809
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.55788249
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.37641888
8VDR_22108803_ChIP-Seq_LS180_Human3.29838202
9GATA4_25053715_ChIP-Seq_YYC3_Human3.26517295
10AR_21909140_ChIP-Seq_LNCAP_Human3.09456117
11POU3F2_20337985_ChIP-ChIP_501MEL_Human3.00892442
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.97663850
13GATA6_25053715_ChIP-Seq_YYC3_Human2.90524106
14SRY_22984422_ChIP-ChIP_TESTIS_Rat2.83915737
15NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.80283722
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.77180679
17HTT_18923047_ChIP-ChIP_STHdh_Human2.63311031
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.40684751
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.39190871
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.31559831
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30299738
22SOX2_20726797_ChIP-Seq_SW620_Human2.29910078
23GATA1_22025678_ChIP-Seq_K562_Human2.20932815
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14033411
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05734077
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04635729
27CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03734149
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.03018379
29EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01771932
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99813674
31KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.98462282
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.97669842
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.94282119
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.93786511
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.88125499
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.86173345
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84398680
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.81482111
39ER_23166858_ChIP-Seq_MCF-7_Human1.77260544
40GBX2_23144817_ChIP-Seq_PC3_Human1.75868815
41IGF1R_20145208_ChIP-Seq_DFB_Human1.75805853
42GATA1_19941826_ChIP-Seq_K562_Human1.75363299
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74742649
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71518348
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71108377
46GATA2_19941826_ChIP-Seq_K562_Human1.70261734
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68841002
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66209113
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.65144890
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63586528
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63052699
52TRIM28_21343339_ChIP-Seq_HEK293_Human1.61670415
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61061974
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59122190
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.53121163
56BCAT_22108803_ChIP-Seq_LS180_Human1.51286599
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50589924
58P53_22387025_ChIP-Seq_ESCs_Mouse1.49699414
59AR_25329375_ChIP-Seq_VCAP_Human1.48552252
60FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47525391
61FOXA1_25329375_ChIP-Seq_VCAP_Human1.47525391
62AR_20517297_ChIP-Seq_VCAP_Human1.46913301
63OCT4_18692474_ChIP-Seq_MEFs_Mouse1.46705226
64STAT3_18555785_Chip-Seq_ESCs_Mouse1.44735295
65* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.44006215
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.43975595
67RACK7_27058665_Chip-Seq_MCF-7_Human1.43580039
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42940330
69* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.42481553
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40363241
71CDX2_22108803_ChIP-Seq_LS180_Human1.39704818
72NANOG_19829295_ChIP-Seq_ESCs_Human1.39468304
73SOX2_19829295_ChIP-Seq_ESCs_Human1.39468304
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39317776
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38866334
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38459136
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38435710
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38061863
79STAT3_23295773_ChIP-Seq_U87_Human1.37334593
80SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36899992
81HNF4A_19822575_ChIP-Seq_HepG2_Human1.36740109
82ESR1_21235772_ChIP-Seq_MCF-7_Human1.36732621
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35532386
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34924482
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34330109
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.33932469
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.32997974
88KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32608128
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30872885
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30603087
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30528573
92FOXA1_25552417_ChIP-Seq_VCAP_Human1.30431938
93TCF4_23295773_ChIP-Seq_U87_Human1.30369344
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.29825200
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29317703
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28817164
97KLF5_25053715_ChIP-Seq_YYC3_Human1.28682338
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.28544165
99ESR2_21235772_ChIP-Seq_MCF-7_Human1.28478713
100PHF8_20622853_ChIP-Seq_HELA_Human1.28162871
101GATA3_21878914_ChIP-Seq_MCF-7_Human1.28045430
102RBPJ_21746931_ChIP-Seq_IB4_Human1.27235310
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25730678
104TP53_22573176_ChIP-Seq_HFKS_Human1.25360309
105NMYC_18555785_Chip-Seq_ESCs_Mouse1.25134572
106SMAD4_21799915_ChIP-Seq_A2780_Human1.23806252
107HNFA_21074721_ChIP-Seq_CACO-2_Human1.23298109
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23256852
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.22853042
110KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22826838
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.22435240
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.21838466
113TCF3_18692474_ChIP-Seq_MESCs_Mouse1.21642559
114IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.21147477
115ATF3_27146783_Chip-Seq_COLON_Human1.20761238
116ZNF274_21170338_ChIP-Seq_K562_Hela1.18823698
117PU1_27457419_Chip-Seq_LIVER_Mouse1.18065581
118CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18035198
119* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.17532429
120NFYB_21822215_ChIP-Seq_K562_Human1.17324421
121NFYA_21822215_ChIP-Seq_K562_Human1.17211123
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17163098
123GATA3_24758297_ChIP-Seq_MCF-7_Human1.16157624
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.15888962
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.15670962
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.15010478
127ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14770725
128P300_19829295_ChIP-Seq_ESCs_Human1.14371825
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14318124
130E2F7_22180533_ChIP-Seq_HELA_Human1.14298435
131P300_18555785_Chip-Seq_ESCs_Mouse1.13885775
132ERG_20517297_ChIP-Seq_VCAP_Human1.13697303
133OCT4_18555785_Chip-Seq_ESCs_Mouse1.13559766
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13136053
135HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12502228
136NANOG_20526341_ChIP-Seq_ESCs_Human1.12458738
137SRF_21415370_ChIP-Seq_HL-1_Mouse1.12311825
138ZFX_18555785_Chip-Seq_ESCs_Mouse1.11900917
139SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11710085
140PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11568010
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11094435
142TBL1_22424771_ChIP-Seq_293T_Human1.09872456
143POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08682493
144CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08580679
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08490190
146ETV1_20927104_ChIP-Seq_GIST48_Human1.08354564
147RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08088590
148ESRRB_18555785_Chip-Seq_ESCs_Mouse1.07784502
149SALL4_22934838_ChIP-ChIP_CD34+_Human1.07632902
150STAT1_20625510_ChIP-Seq_HELA_Human1.07152088
151PIAS1_25552417_ChIP-Seq_VCAP_Human1.06623528
152RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05752609
153ELF5_23300383_ChIP-Seq_T47D_Human1.05479966
154FOXM1_23109430_ChIP-Seq_U2OS_Human1.04714523
155POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02443613
156* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01576510
157KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01326387
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00785047
159SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99835177
160PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.99037576
161PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96844657
162* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.96706172
163SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96588344
164PHF8_20622854_ChIP-Seq_HELA_Human0.95350200
165KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95151501
166TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93779333
167GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93201083
168FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93048212
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92607151
170NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90941786
171P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89611504
172LXR_22292898_ChIP-Seq_THP-1_Human0.88813671
173* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88225348
174CTCF_27219007_Chip-Seq_Bcells_Human0.87432419
175FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.85171625
176ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84650832
177NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84237336
178E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83094291
179KAP1_27257070_Chip-Seq_ESCs_Mouse0.82678694
180TET1_21451524_ChIP-Seq_MESCs_Mouse0.82148096
181BCL6_27268052_Chip-Seq_Bcells_Human0.81583626
182FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80794129
183NCOR_22424771_ChIP-Seq_293T_Human0.80464606
184MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80224579
185STAT1_17558387_ChIP-Seq_HELA_Human0.79993424
186RARA_24833708_ChIP-Seq_LIVER_Mouse0.79587631
187ZNF263_19887448_ChIP-Seq_K562_Human0.79449507
188JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78831638

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.25083346
2MP0005464_abnormal_platelet_physiology4.98702619
3MP0002139_abnormal_hepatobiliary_system4.82181104
4MP0001666_abnormal_nutrient_absorption4.14414156
5MP0003283_abnormal_digestive_organ4.05546060
6MP0004019_abnormal_vitamin_homeostasis3.65463059
7MP0005085_abnormal_gallbladder_physiolo3.62258393
8MP0003011_delayed_dark_adaptation3.60961212
9MP0004043_abnormal_pH_regulation3.38036486
10MP0000462_abnormal_digestive_system3.32817175
11MP0008875_abnormal_xenobiotic_pharmacok3.08986560
12MP0004264_abnormal_extraembryonic_tissu3.02057406
13MP0003252_abnormal_bile_duct2.97692212
14MP0009780_abnormal_chondrocyte_physiolo2.84020023
15MP0005377_hearing/vestibular/ear_phenot2.77610067
16MP0003878_abnormal_ear_physiology2.77610067
17MP0005646_abnormal_pituitary_gland2.71895998
18MP0005645_abnormal_hypothalamus_physiol2.56663790
19MP0005365_abnormal_bile_salt2.52940520
20MP0010234_abnormal_vibrissa_follicle2.50181600
21MP0005332_abnormal_amino_acid2.36191325
22MP0008877_abnormal_DNA_methylation2.35041915
23MP0009643_abnormal_urine_homeostasis2.29527278
24MP0009379_abnormal_foot_pigmentation2.28780679
25MP0001664_abnormal_digestion2.11344851
26MP0003866_abnormal_defecation2.03779553
27MP0000490_abnormal_crypts_of2.03594352
28MP0004215_abnormal_myocardial_fiber2.01933303
29MP0003868_abnormal_feces_composition1.94883923
30MP0005381_digestive/alimentary_phenotyp1.93808220
31MP0001873_stomach_inflammation1.92862458
32MP0001663_abnormal_digestive_system1.91512501
33MP0003300_gastrointestinal_ulcer1.87366571
34MP0002138_abnormal_hepatobiliary_system1.82267178
35MP0002837_dystrophic_cardiac_calcinosis1.80758550
36MP0010155_abnormal_intestine_physiology1.79824257
37MP0000538_abnormal_urinary_bladder1.79283831
38MP0000537_abnormal_urethra_morphology1.73115672
39MP0001765_abnormal_ion_homeostasis1.71269455
40MP0000477_abnormal_intestine_morphology1.66771234
41MP0005410_abnormal_fertilization1.65050526
42MP0005379_endocrine/exocrine_gland_phen1.64264774
43MP0005451_abnormal_body_composition1.63485089
44MP0002078_abnormal_glucose_homeostasis1.60358113
45MP0003806_abnormal_nucleotide_metabolis1.56040598
46MP0002822_catalepsy1.53987040
47MP0005636_abnormal_mineral_homeostasis1.53595354
48MP0003724_increased_susceptibility_to1.53144800
49MP0005084_abnormal_gallbladder_morpholo1.52497152
50MP0002277_abnormal_respiratory_mucosa1.51888485
51MP0002909_abnormal_adrenal_gland1.49579814
52MP0009697_abnormal_copulation1.48455358
53MP0010329_abnormal_lipoprotein_level1.48072701
54MP0008775_abnormal_heart_ventricle1.47905953
55MP0008004_abnormal_stomach_pH1.45133856
56MP0009840_abnormal_foam_cell1.44091364
57MP0002638_abnormal_pupillary_reflex1.43093267
58MP0001756_abnormal_urination1.42962906
59MP0002136_abnormal_kidney_physiology1.42852567
60MP0004134_abnormal_chest_morphology1.40162948
61MP0001905_abnormal_dopamine_level1.37821805
62MP0002693_abnormal_pancreas_physiology1.36762252
63MP0003315_abnormal_perineum_morphology1.36631623
64MP0008995_early_reproductive_senescence1.35646010
65MP0002796_impaired_skin_barrier1.30868980
66MP0005058_abnormal_lysosome_morphology1.30339471
67MP0005666_abnormal_adipose_tissue1.21547878
68MP0010386_abnormal_urinary_bladder1.18420990
69MP0005551_abnormal_eye_electrophysiolog1.17388890
70MP0003693_abnormal_embryo_hatching1.17284973
71MP0000678_abnormal_parathyroid_gland1.17153250
72MP0005535_abnormal_body_temperature1.16312741
73MP0006072_abnormal_retinal_apoptosis1.15941161
74MP0001944_abnormal_pancreas_morphology1.13386418
75MP0001764_abnormal_homeostasis1.10687094
76MP0009384_cardiac_valve_regurgitation1.04994222
77MP0006035_abnormal_mitochondrial_morpho1.04923459
78MP0000013_abnormal_adipose_tissue1.02647395
79MP0003718_maternal_effect1.01905366
80MP0008872_abnormal_physiological_respon1.01704447
81MP0010352_gastrointestinal_tract_polyps1.01143887
82MP0003191_abnormal_cellular_cholesterol1.00849592
83MP0002733_abnormal_thermal_nociception0.99901751
84MP0003195_calcinosis0.99717452
85MP0001881_abnormal_mammary_gland0.96367572
86MP0001929_abnormal_gametogenesis0.95676414
87MP0002089_abnormal_postnatal_growth/wei0.95290391
88MP0004957_abnormal_blastocyst_morpholog0.94870695
89MP0001485_abnormal_pinna_reflex0.92628244
90MP0003705_abnormal_hypodermis_morpholog0.91706891
91MP0003656_abnormal_erythrocyte_physiolo0.90783117
92MP0005174_abnormal_tail_pigmentation0.90516796
93MP0005389_reproductive_system_phenotype0.89674239
94MP0002118_abnormal_lipid_homeostasis0.89296846
95MP0005167_abnormal_blood-brain_barrier0.89078166
96MP0003786_premature_aging0.87348579
97MP0001849_ear_inflammation0.87202805
98MP0005448_abnormal_energy_balance0.85974703
99MP0003698_abnormal_male_reproductive0.84716704
100MP0005397_hematopoietic_system_phenotyp0.84667134
101MP0001545_abnormal_hematopoietic_system0.84667134
102MP0005319_abnormal_enzyme/_coenzyme0.83837319
103MP0005501_abnormal_skin_physiology0.83261664
104MP0000653_abnormal_sex_gland0.82049513
105MP0001970_abnormal_pain_threshold0.80960992
106MP0000470_abnormal_stomach_morphology0.80476728
107MP0003183_abnormal_peptide_metabolism0.80217026
108MP0001919_abnormal_reproductive_system0.79317408
109MP0003941_abnormal_skin_development0.79224316
110MP0000358_abnormal_cell_content/0.79097033
111MP0000639_abnormal_adrenal_gland0.78655426
112MP0003122_maternal_imprinting0.77789770
113MP0002098_abnormal_vibrissa_morphology0.77591413
114MP0006036_abnormal_mitochondrial_physio0.76020115
115MP0003186_abnormal_redox_activity0.74446041
116MP0004085_abnormal_heartbeat0.73309190
117MP0001145_abnormal_male_reproductive0.73085911
118MP0002876_abnormal_thyroid_physiology0.72880379
119MP0008057_abnormal_DNA_replication0.71789756
120MP0002160_abnormal_reproductive_system0.71672078
121MP0005584_abnormal_enzyme/coenzyme_acti0.70795510
122MP0000427_abnormal_hair_cycle0.70646508
123MP0005083_abnormal_biliary_tract0.69927278
124MP0002210_abnormal_sex_determination0.68698529
125MP0003119_abnormal_digestive_system0.67881519
126MP0005165_increased_susceptibility_to0.66228899
127MP0003879_abnormal_hair_cell0.66161948
128MP0000613_abnormal_salivary_gland0.66062563
129MP0004130_abnormal_muscle_cell0.65925616
130MP0003172_abnormal_lysosome_physiology0.65823136
131MP0000609_abnormal_liver_physiology0.65677405
132MP0004147_increased_porphyrin_level0.65665456
133MP0000467_abnormal_esophagus_morphology0.63658159
134MP0003045_fibrosis0.63588834
135MP0009046_muscle_twitch0.61529196
136MP0005220_abnormal_exocrine_pancreas0.60618637
137MP0009642_abnormal_blood_homeostasis0.55118480
138MP0000230_abnormal_systemic_arterial0.53945234
139MP0002928_abnormal_bile_duct0.53746794
140MP0003638_abnormal_response/metabolism_0.53590208
141MP0004484_altered_response_of0.52376906
142MP0005266_abnormal_metabolism0.47865231
143MP0004885_abnormal_endolymph0.47136298
144MP0005376_homeostasis/metabolism_phenot0.47026112
145MP0008961_abnormal_basal_metabolism0.46535305
146MP0010678_abnormal_skin_adnexa0.45681802
147MP0005367_renal/urinary_system_phenotyp0.45595029
148MP0000516_abnormal_urinary_system0.45595029
149MP0004185_abnormal_adipocyte_glucose0.45136927
150MP0002132_abnormal_respiratory_system0.43626470
151MP0001216_abnormal_epidermal_layer0.40681735
152MP0005375_adipose_tissue_phenotype0.39925196
153MP0009333_abnormal_splenocyte_physiolog0.39894404
154MP0001730_embryonic_growth_arrest0.39310027
155MP0003953_abnormal_hormone_level0.39232042

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.81864747
2Ileus (HP:0002595)5.52335147
3Abnormality of glutamine family amino acid metabolism (HP:0010902)5.49253961
4Petechiae (HP:0000967)4.91068012
5Hyperglycinuria (HP:0003108)4.86135221
6Metabolic alkalosis (HP:0200114)4.73513903
7Menorrhagia (HP:0000132)4.64917291
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.62544900
9Abnormality of chloride homeostasis (HP:0011422)4.57128404
10Hyperactive renin-angiotensin system (HP:0000841)4.50364268
11Widely patent fontanelles and sutures (HP:0004492)4.35110948
12Glycosuria (HP:0003076)4.30623717
13Abnormality of urine glucose concentration (HP:0011016)4.30623717
14Abnormal hemoglobin (HP:0011902)4.25727282
15Increased mean platelet volume (HP:0011877)4.21486054
16Proximal tubulopathy (HP:0000114)4.11284635
17Gout (HP:0001997)4.05963666
18Hyperlipoproteinemia (HP:0010980)4.00055368
19Increased circulating renin level (HP:0000848)3.91846844
20Generalized aminoaciduria (HP:0002909)3.84640984
21Abnormality of serine family amino acid metabolism (HP:0010894)3.84305728
22Abnormality of glycine metabolism (HP:0010895)3.84305728
23Abnormal platelet volume (HP:0011876)3.77781543
24Delayed epiphyseal ossification (HP:0002663)3.73701329
25Purpura (HP:0000979)3.62157889
26Abnormality of magnesium homeostasis (HP:0004921)3.57376282
27Malnutrition (HP:0004395)3.54145079
28Abnormality of proline metabolism (HP:0010907)3.52023232
29Hydroxyprolinuria (HP:0003080)3.52023232
30Thin bony cortex (HP:0002753)3.48509599
31Abnormality of the vitamin B12 metabolism (HP:0004341)3.47493408
32Abnormality of purine metabolism (HP:0004352)3.46838513
33Right ventricular cardiomyopathy (HP:0011663)3.44878323
34Abnormal urine output (HP:0012590)3.43595991
35Hypokalemic alkalosis (HP:0001949)3.38263721
36Hyperphosphaturia (HP:0003109)3.37629564
37Hypomagnesemia (HP:0002917)3.35016040
38Hyperuricemia (HP:0002149)3.33187373
39Increased purine levels (HP:0004368)3.33187373
40Reticulocytopenia (HP:0001896)3.32600164
41Mesangial abnormality (HP:0001966)3.26711846
42Abnormality of renal excretion (HP:0011036)3.24564240
43Abnormality of vitamin B metabolism (HP:0004340)3.21697773
44Dyschromatopsia (HP:0007641)3.14268132
45Gingival bleeding (HP:0000225)3.13974651
46Polyuria (HP:0000103)3.12898031
47Spontaneous abortion (HP:0005268)3.11435171
48Epistaxis (HP:0000421)3.10935707
49Abnormal urine phosphate concentration (HP:0012599)3.09844718
50Confusion (HP:0001289)3.08737965
513-Methylglutaconic aciduria (HP:0003535)3.08526009
52Abnormality of aspartate family amino acid metabolism (HP:0010899)3.00623433
53Alkalosis (HP:0001948)2.99226633
54Hyperthyroidism (HP:0000836)2.98849001
55Wide cranial sutures (HP:0010537)2.98501858
56Abdominal distention (HP:0003270)2.95864324
57Neuroendocrine neoplasm (HP:0100634)2.95109731
58Poikilocytosis (HP:0004447)2.92866130
59Abnormality of nucleobase metabolism (HP:0010932)2.92055521
60Abnormality of renin-angiotensin system (HP:0000847)2.91701523
61Acute necrotizing encephalopathy (HP:0006965)2.83912243
62Pheochromocytoma (HP:0002666)2.82772805
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82758183
64Abnormality of alanine metabolism (HP:0010916)2.82758183
65Hyperalaninemia (HP:0003348)2.82758183
66Hypobetalipoproteinemia (HP:0003563)2.80159010
67Abnormal pancreas size (HP:0012094)2.79886683
68Macrocytic anemia (HP:0001972)2.79719658
69Dehydration (HP:0001944)2.79680135
70Hyperammonemia (HP:0001987)2.78983164
71Lethargy (HP:0001254)2.71031885
72Hypoglycemic seizures (HP:0002173)2.68917609
73Progressive macrocephaly (HP:0004481)2.67117168
74Nephrolithiasis (HP:0000787)2.65357223
75Renal cortical cysts (HP:0000803)2.64343190
76Enlarged epiphyses (HP:0010580)2.63797330
77Symptomatic seizures (HP:0011145)2.62647903
78Hyperaldosteronism (HP:0000859)2.62566207
79Hypercalciuria (HP:0002150)2.60131457
80Abnormality of vitamin metabolism (HP:0100508)2.58010614
81Hyperglycinemia (HP:0002154)2.54010866
82Large for gestational age (HP:0001520)2.53101096
83Ventricular fibrillation (HP:0001663)2.52442038
84Abnormality of the costochondral junction (HP:0000919)2.52175491
85Dicarboxylic aciduria (HP:0003215)2.51657821
86Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51657821
87Hypophosphatemia (HP:0002148)2.51536203
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.51342510
89Hypothermia (HP:0002045)2.51278698
90Hyperglycemia (HP:0003074)2.49377161
91Pancreatic islet-cell hyperplasia (HP:0004510)2.48398171
92Nausea (HP:0002018)2.46332091
93Abnormal mitochondria in muscle tissue (HP:0008316)2.45646858
94Hyperinsulinemic hypoglycemia (HP:0000825)2.43218294
95Acute encephalopathy (HP:0006846)2.42312772
96Megaloblastic anemia (HP:0001889)2.42112073
97Rickets (HP:0002748)2.41627408
98Metabolic acidosis (HP:0001942)2.41511196
99Hyperparathyroidism (HP:0000843)2.39398250
100Conjugated hyperbilirubinemia (HP:0002908)2.38462931
101Polydipsia (HP:0001959)2.37744229
102Abnormal drinking behavior (HP:0030082)2.37744229
103Congenital sensorineural hearing impairment (HP:0008527)2.37529584
104Renal salt wasting (HP:0000127)2.33102330
105Abnormality of sulfur amino acid metabolism (HP:0004339)2.31347304
106Abnormal tarsal ossification (HP:0008369)2.30986277
107Abnormality of the renal cortex (HP:0011035)2.30940319
108Ketoacidosis (HP:0001993)2.30293907
109Tinnitus (HP:0000360)2.30275270
110Impaired platelet aggregation (HP:0003540)2.27349876
111Abnormal platelet function (HP:0011869)2.27349876
112Abnormality of the heme biosynthetic pathway (HP:0010472)2.27248415
113Abnormality of fatty-acid metabolism (HP:0004359)2.25151913
114Fat malabsorption (HP:0002630)2.23322923
115Attenuation of retinal blood vessels (HP:0007843)2.23112612
116Xanthomatosis (HP:0000991)2.21891972
117Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18434007
118Decreased central vision (HP:0007663)2.17673976
119Woolly hair (HP:0002224)2.16867599
120Renal Fanconi syndrome (HP:0001994)2.16010885
121Paralysis (HP:0003470)2.15346875
122Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.14937171
123Intrahepatic cholestasis (HP:0001406)2.14402339
124Tetany (HP:0001281)2.13092059
125Vomiting (HP:0002013)2.12275639
126Lipid accumulation in hepatocytes (HP:0006561)2.09671631
127Acanthocytosis (HP:0001927)2.06607538
128Hepatic necrosis (HP:0002605)2.05819908
129Meningioma (HP:0002858)2.05413838
130Intestinal atresia (HP:0011100)2.05156210
131Vacuolated lymphocytes (HP:0001922)2.05109685
132Hypoalbuminemia (HP:0003073)2.03727718
133Abnormal albumin level (HP:0012116)2.03727718
134Hypoglycemic coma (HP:0001325)2.03418950
135Rectal prolapse (HP:0002035)2.01971652
136Limb hypertonia (HP:0002509)2.00623812
137Azoospermia (HP:0000027)2.00565645
138Tongue fasciculations (HP:0001308)2.00103817
139Hypokalemia (HP:0002900)1.99154208
140Bilateral sensorineural hearing impairment (HP:0008619)1.98600740
141Cardiovascular calcification (HP:0011915)1.98188648
142Ketosis (HP:0001946)1.97417397
143Abnormality of the common coagulation pathway (HP:0010990)1.96893010
144Testicular neoplasm (HP:0010788)1.96831941
145Septate vagina (HP:0001153)1.96447695
146Mitochondrial inheritance (HP:0001427)1.95637968
147Pili torti (HP:0003777)1.95466435
148Episodic fever (HP:0001954)1.95370694
149Vascular calcification (HP:0004934)1.95068611
150Cerebral edema (HP:0002181)1.94445984
151Increased CSF lactate (HP:0002490)1.94408747
152Abnormal biliary tract morphology (HP:0012440)1.94304128
153Abnormality of endocrine pancreas physiology (HP:0012093)1.93701314
154Abnormality of the pancreatic islet cells (HP:0006476)1.93701314
155Biliary tract neoplasm (HP:0100574)1.92338578
156Increased muscle lipid content (HP:0009058)1.91530774
157Abnormality of renal resorption (HP:0011038)1.91128939
158Abnormality of carpal bone ossification (HP:0006257)1.90552600
159Postural tremor (HP:0002174)1.90547780
160Abnormal pupillary function (HP:0007686)1.89067964
161Increased serum pyruvate (HP:0003542)1.87928814
162Abnormality of the 1st metacarpal (HP:0010009)1.87869519
163Chronic diarrhea (HP:0002028)1.87346992
164Cupped ribs (HP:0000887)1.86857319
165Abnormality of glycolysis (HP:0004366)1.85041472
166Neoplasm of the small intestine (HP:0100833)1.82586376
167Medial flaring of the eyebrow (HP:0010747)1.82434021
168Insulin-resistant diabetes mellitus (HP:0000831)1.76810577
169Hamartoma of the eye (HP:0010568)1.72636733
170Abnormal rod and cone electroretinograms (HP:0008323)1.72461534
171Abnormal spermatogenesis (HP:0008669)1.72383566
172Joint swelling (HP:0001386)1.71866643

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME16.28461014
2LMTK24.87242313
3MST1R4.36741833
4FRK4.34532677
5WNK43.95712196
6MST43.64375163
7OXSR13.29823418
8STK393.07328178
9WNK33.04085828
10ADRBK22.62922853
11ACVR1B2.57394689
12MAP4K22.46586968
13NME22.45766102
14PBK2.30249003
15MAPKAPK32.19490832
16STK242.19036589
17BMPR22.09906024
18PASK2.09285890
19MAP2K22.01783712
20ILK1.98642168
21PTK2B1.97511212
22PRKG21.95939161
23RIPK41.87869131
24NEK11.84577133
25MAP3K111.81552326
26PLK41.74472767
27GRK61.64862243
28EPHA21.63309309
29NEK21.61921828
30STK38L1.56005308
31TRIM281.52177777
32PTK61.50042690
33RPS6KB21.48759561
34EPHB21.41632464
35MET1.40643063
36PDK31.39310820
37PDK41.39310820
38NUAK11.35236652
39BTK1.33844437
40FER1.30407149
41BRSK21.29867211
42TTK1.24058182
43PDK21.23832968
44DAPK21.23412912
45PHKG11.19550858
46PHKG21.19550858
47TAOK31.17916251
48EIF2AK11.10430552
49MAP2K61.07127735
50MAPK131.06582138
51EIF2AK31.04986557
52LATS11.04984911
53MAP3K121.03595350
54BMPR1B1.03506170
55ZAK1.01248458
56MAP3K71.00973757
57PIK3CG0.99361677
58ITK0.96950248
59PAK30.96047590
60BCKDK0.93594656
61PLK20.92938897
62AKT30.92825925
63AURKB0.89596831
64CAMKK20.87863872
65DAPK10.87500835
66GRK50.86875012
67NTRK30.86599109
68PLK30.86406546
69STK40.85642541
70PIK3CA0.85145962
71TEC0.83278250
72INSRR0.80476386
73DYRK30.80365763
74ZAP700.78675690
75MAP3K20.78475965
76MAP3K80.78283925
77CASK0.77666218
78ADRBK10.75405107
79ERBB30.72513796
80PRKCE0.71004782
81DAPK30.68591967
82TNIK0.66389475
83PRKCI0.66086844
84PAK40.65634498
85MAP3K40.63409215
86CSF1R0.62937383
87PRKAA20.61918645
88PRKCG0.60957491
89TLK10.60856680
90TNK20.60797684
91STK160.60104454
92ERBB20.57322168
93YES10.57212350
94CDK120.56831928
95FGFR30.55294757
96FGFR20.54917367
97CSNK1G30.54302717
98IKBKB0.54085982
99HCK0.53626883
100PLK10.51561770
101CDK70.51557147
102VRK10.50807409
103STK100.50155542
104MAP2K10.49893906
105RIPK10.49736190
106WNK10.48593515
107SYK0.46797687
108CAMK2G0.45078993
109PRKAA10.44539079
110BRAF0.44518948
111GRK10.43830138
112CAMK1G0.41506161
113BLK0.40915624
114CSNK1G20.39938162
115MAPK110.39612307
116KSR20.39547226
117CLK10.39071566
118MKNK20.38387504
119LRRK20.37586150
120PRKD30.36632481
121DDR20.36555566
122CSNK1G10.36373069
123MAPKAPK50.35828420
124CAMK2D0.35328127
125PINK10.34764083
126MYLK0.33810003
127CAMK2B0.33723423
128MAP3K100.33441033
129PRKG10.32874230
130PTK20.31044395
131RPS6KA50.30608319
132ERN10.30403776
133PRKACA0.30375106
134PRKCB0.29748836
135TESK10.29131930
136PRKD10.29130664
137STK380.28529520
138IRAK30.28508305
139ERBB40.28454537
140CSNK1A10.27485632
141BMX0.27340718
142PRKCA0.25565622
143PAK10.25340471
144MAP3K10.24758482
145STK30.24667072
146GSK3A0.23894681
147STK110.23832818
148DYRK1B0.23687165
149MATK0.23440501
150CSK0.21995803
151CAMKK10.21808402
152PDPK10.20771610
153TAOK10.19814745
154BUB10.17964712
155PIM20.17464192
156AURKA0.17334846
157CHEK20.16971544
158CDK60.14236282
159PRKACG0.12462387
160CSNK1E0.12243175
161AKT20.10930690
162ARAF0.09929604
163MAP3K130.09925909
164CSNK2A20.09420605

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.18900827
2Sulfur metabolism_Homo sapiens_hsa009203.09911381
3Mineral absorption_Homo sapiens_hsa049782.86312816
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.82062887
5Vitamin digestion and absorption_Homo sapiens_hsa049772.79190751
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.51533179
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37257788
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.34152933
9Folate biosynthesis_Homo sapiens_hsa007902.28954321
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.25857640
11Renin-angiotensin system_Homo sapiens_hsa046142.25847956
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.12195368
13Fructose and mannose metabolism_Homo sapiens_hsa000512.10031032
14Glutathione metabolism_Homo sapiens_hsa004802.06279346
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04079351
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92236701
17Bile secretion_Homo sapiens_hsa049761.90242791
18Butanoate metabolism_Homo sapiens_hsa006501.85521258
19Galactose metabolism_Homo sapiens_hsa000521.84565676
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82988174
21Linoleic acid metabolism_Homo sapiens_hsa005911.81930925
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.76550451
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74308034
24Starch and sucrose metabolism_Homo sapiens_hsa005001.73083162
25Tryptophan metabolism_Homo sapiens_hsa003801.71714206
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66877096
27Protein digestion and absorption_Homo sapiens_hsa049741.66211867
28Oxidative phosphorylation_Homo sapiens_hsa001901.62289081
29Fatty acid degradation_Homo sapiens_hsa000711.61346873
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61019284
31Ribosome_Homo sapiens_hsa030101.59786676
32Histidine metabolism_Homo sapiens_hsa003401.59218251
33Protein export_Homo sapiens_hsa030601.58378548
34Arginine and proline metabolism_Homo sapiens_hsa003301.55133830
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.53239140
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53055568
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49187437
38Nitrogen metabolism_Homo sapiens_hsa009101.48563832
39Propanoate metabolism_Homo sapiens_hsa006401.44712272
40Pentose phosphate pathway_Homo sapiens_hsa000301.44370716
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43586412
42Arachidonic acid metabolism_Homo sapiens_hsa005901.40244981
43Platelet activation_Homo sapiens_hsa046111.38819035
44PPAR signaling pathway_Homo sapiens_hsa033201.36225153
45Parkinsons disease_Homo sapiens_hsa050121.33700572
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32029957
47Pyruvate metabolism_Homo sapiens_hsa006201.31887211
48Carbon metabolism_Homo sapiens_hsa012001.29688409
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27555819
50beta-Alanine metabolism_Homo sapiens_hsa004101.24183451
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22637906
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21509967
53Arginine biosynthesis_Homo sapiens_hsa002201.19460753
54Glycerolipid metabolism_Homo sapiens_hsa005611.14085238
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06714678
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05721887
57Peroxisome_Homo sapiens_hsa041461.05091601
58Selenocompound metabolism_Homo sapiens_hsa004501.03800426
59Chemical carcinogenesis_Homo sapiens_hsa052041.03114017
60Huntingtons disease_Homo sapiens_hsa050161.02185697
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98301555
62Insulin secretion_Homo sapiens_hsa049110.94476878
63Fatty acid biosynthesis_Homo sapiens_hsa000610.94267932
64Complement and coagulation cascades_Homo sapiens_hsa046100.93423043
65Other glycan degradation_Homo sapiens_hsa005110.93071452
66Tyrosine metabolism_Homo sapiens_hsa003500.93049232
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91528110
68Alzheimers disease_Homo sapiens_hsa050100.89900654
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.89086002
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84003992
71Caffeine metabolism_Homo sapiens_hsa002320.82746793
72Ether lipid metabolism_Homo sapiens_hsa005650.81269702
73Serotonergic synapse_Homo sapiens_hsa047260.79404778
74Biosynthesis of amino acids_Homo sapiens_hsa012300.78653900
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78489155
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75106887
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74652246
78Retinol metabolism_Homo sapiens_hsa008300.74405502
79ABC transporters_Homo sapiens_hsa020100.73450090
80Sulfur relay system_Homo sapiens_hsa041220.71740300
81Metabolic pathways_Homo sapiens_hsa011000.71460904
82Fatty acid metabolism_Homo sapiens_hsa012120.69908975
83Pancreatic secretion_Homo sapiens_hsa049720.65971987
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63124937
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.62976159
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.62059468
87Thyroid hormone synthesis_Homo sapiens_hsa049180.55812731
88Sphingolipid metabolism_Homo sapiens_hsa006000.55696479
89Phototransduction_Homo sapiens_hsa047440.55664036
90Tight junction_Homo sapiens_hsa045300.54577088
91Cardiac muscle contraction_Homo sapiens_hsa042600.54354923
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.52569600
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52077008
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.49861434
95Lysine degradation_Homo sapiens_hsa003100.49577131
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.46584255
97Inositol phosphate metabolism_Homo sapiens_hsa005620.44655686
98Olfactory transduction_Homo sapiens_hsa047400.43351024
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42287508
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40947822
101Phenylalanine metabolism_Homo sapiens_hsa003600.36437214
102Vibrio cholerae infection_Homo sapiens_hsa051100.34965487
103Steroid biosynthesis_Homo sapiens_hsa001000.33618585
104Regulation of autophagy_Homo sapiens_hsa041400.32311429
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31757546
106Gastric acid secretion_Homo sapiens_hsa049710.31279288
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31121220
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29719778
109Type II diabetes mellitus_Homo sapiens_hsa049300.29345366
110Circadian entrainment_Homo sapiens_hsa047130.26949991
111Fanconi anemia pathway_Homo sapiens_hsa034600.26070943
112Vitamin B6 metabolism_Homo sapiens_hsa007500.25669381
113Taste transduction_Homo sapiens_hsa047420.24820987
114Pyrimidine metabolism_Homo sapiens_hsa002400.23037276
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.21164049
116Ovarian steroidogenesis_Homo sapiens_hsa049130.21150796
117Fatty acid elongation_Homo sapiens_hsa000620.19935092
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.18376712
119Purine metabolism_Homo sapiens_hsa002300.17150186
120One carbon pool by folate_Homo sapiens_hsa006700.16495100
121Bladder cancer_Homo sapiens_hsa052190.14939582
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.13081323
123Leukocyte transendothelial migration_Homo sapiens_hsa046700.12979254
124Hepatitis C_Homo sapiens_hsa051600.12040415
125Collecting duct acid secretion_Homo sapiens_hsa049660.09681022

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