GLIPR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.54528165
2neutrophil activation involved in immune response (GO:0002283)4.94182452
3negative regulation of cell killing (GO:0031342)4.61497940
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.61497940
5response to peptidoglycan (GO:0032494)4.40501997
6regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.15621682
7positive regulation by symbiont of host defense response (GO:0052509)4.07174183
8modulation by symbiont of host defense response (GO:0052031)4.07174183
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07174183
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07174183
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.07174183
12modulation by symbiont of host immune response (GO:0052553)4.07174183
13immunoglobulin mediated immune response (GO:0016064)4.00078783
14detection of other organism (GO:0098543)3.95061494
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92462384
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92462384
17respiratory burst (GO:0045730)3.90086467
18detection of molecule of bacterial origin (GO:0032490)3.89916948
19neutrophil activation (GO:0042119)3.77539496
20antigen processing and presentation of endogenous antigen (GO:0019883)3.71454463
21positive regulation of gamma-delta T cell activation (GO:0046645)3.69054958
22detection of bacterium (GO:0016045)3.62141635
23granulocyte activation (GO:0036230)3.61827177
24response to interferon-beta (GO:0035456)3.60900289
25detection of external biotic stimulus (GO:0098581)3.60449334
26regulation of B cell receptor signaling pathway (GO:0050855)3.56672641
27ribosomal small subunit assembly (GO:0000028)3.52287948
28mast cell activation (GO:0045576)3.41411209
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.40204065
30neutrophil mediated immunity (GO:0002446)3.39749991
31defense response to protozoan (GO:0042832)3.36290290
32cellular response to interferon-beta (GO:0035458)3.35393603
33positive regulation of antigen processing and presentation (GO:0002579)3.34540948
34regulation of gamma-delta T cell activation (GO:0046643)3.31421693
35microglial cell activation (GO:0001774)3.29762500
36response to protozoan (GO:0001562)3.22472096
37myeloid cell activation involved in immune response (GO:0002275)3.21915892
38negative regulation of phagocytosis (GO:0050765)3.21882284
39regulation of macrophage cytokine production (GO:0010935)3.21793652
40positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.21251754
41positive regulation of interferon-alpha production (GO:0032727)3.21175601
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20762693
43cellular response to type I interferon (GO:0071357)3.19914091
44type I interferon signaling pathway (GO:0060337)3.19914091
45regulation of interferon-beta biosynthetic process (GO:0045357)3.19584616
46detection of biotic stimulus (GO:0009595)3.19330072
47myeloid dendritic cell activation (GO:0001773)3.19034309
48superoxide anion generation (GO:0042554)3.18239538
49regulation of antigen processing and presentation (GO:0002577)3.18236949
50response to muramyl dipeptide (GO:0032495)3.17337563
51response to type I interferon (GO:0034340)3.16844877
52regulation of mast cell activation (GO:0033003)3.15979832
53positive thymic T cell selection (GO:0045059)3.14519502
54B cell mediated immunity (GO:0019724)3.14404309
55negative thymic T cell selection (GO:0045060)3.10516466
56positive regulation of macrophage cytokine production (GO:0060907)3.09704367
57regulation of interferon-alpha production (GO:0032647)3.08999857
58negative T cell selection (GO:0043383)3.07675265
59regulation of T cell tolerance induction (GO:0002664)3.06842643
60negative regulation of T cell mediated immunity (GO:0002710)3.06319481
61positive regulation of B cell differentiation (GO:0045579)3.04648399
62leukocyte aggregation (GO:0070486)3.01782195
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00452726
64regulation of tolerance induction (GO:0002643)3.00437801
65regulation of mast cell degranulation (GO:0043304)2.99816810
66positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.97480870
67response to interleukin-15 (GO:0070672)2.96595774
68macrophage activation (GO:0042116)2.95644931
69response to interferon-alpha (GO:0035455)2.95418397
70production of molecular mediator involved in inflammatory response (GO:0002532)2.95183744
71leukocyte degranulation (GO:0043299)2.95101003
72membrane raft organization (GO:0031579)2.93648720
73positive regulation of mast cell activation involved in immune response (GO:0033008)2.93596740
74positive regulation of mast cell degranulation (GO:0043306)2.93596740
75macrophage activation involved in immune response (GO:0002281)2.92777138
76NIK/NF-kappaB signaling (GO:0038061)2.92128084
77regulation of gamma-delta T cell differentiation (GO:0045586)2.91240641
78antigen processing and presentation via MHC class Ib (GO:0002475)2.90447090
79negative regulation of viral genome replication (GO:0045071)2.90253023
80response to host immune response (GO:0052572)2.90192766
81response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90192766
82myeloid dendritic cell differentiation (GO:0043011)2.90162307
83regulation of leukocyte degranulation (GO:0043300)2.89594275
84negative regulation of myeloid cell apoptotic process (GO:0033033)2.87978619
85positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87619810
86cellular response to zinc ion (GO:0071294)2.86008054
87pinocytosis (GO:0006907)2.85930985
88interferon-gamma-mediated signaling pathway (GO:0060333)2.85640639
89regulation of B cell differentiation (GO:0045577)2.84122612
90regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83820493
91leukocyte mediated cytotoxicity (GO:0001909)2.83468123
92T cell migration (GO:0072678)2.81729812
93B cell receptor signaling pathway (GO:0050853)2.81267872
94positive regulation of monocyte chemotaxis (GO:0090026)2.80273926
95cellular response to interleukin-15 (GO:0071350)2.79583862
96reactive oxygen species biosynthetic process (GO:1903409)2.79338023
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78377041
98myeloid leukocyte mediated immunity (GO:0002444)2.78355172
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77930118
100positive regulation of mast cell activation (GO:0033005)2.77709791
101negative regulation of lymphocyte mediated immunity (GO:0002707)2.77320770
102cellular extravasation (GO:0045123)2.76872172
103regulation of mast cell activation involved in immune response (GO:0033006)2.76212985
104negative regulation of interleukin-12 production (GO:0032695)2.76032351
105positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.75649041
106regulation of monocyte chemotaxis (GO:0090025)2.75399190
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73305025
108myeloid leukocyte activation (GO:0002274)2.72700475
109negative regulation of leukocyte mediated immunity (GO:0002704)2.72320385
110natural killer cell mediated cytotoxicity (GO:0042267)2.71908133
111natural killer cell mediated immunity (GO:0002228)2.71908133
112negative regulation of growth of symbiont in host (GO:0044130)2.70840023
113negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.70840023
114modulation of growth of symbiont involved in interaction with host (GO:0044144)2.70840023
115regulation of growth of symbiont in host (GO:0044126)2.70840023
116DNA deamination (GO:0045006)2.69535260
117actin nucleation (GO:0045010)2.67930168
118response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.66313568
119response to host (GO:0075136)2.66313568
120response to host defenses (GO:0052200)2.66313568
121positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.66027588
122negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64851131
123regulation of T-helper 2 cell differentiation (GO:0045628)2.64441256
124positive regulation of tolerance induction (GO:0002645)2.64299985
125positive regulation of interleukin-1 beta secretion (GO:0050718)2.63872719
126regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63755436
127positive regulation of macrophage differentiation (GO:0045651)2.63394203
128endosome to melanosome transport (GO:0035646)2.61124582
129endosome to pigment granule transport (GO:0043485)2.61124582
130dendritic cell differentiation (GO:0097028)2.60784123
131negative regulation of mast cell activation (GO:0033004)2.60098482
132positive regulation of interferon-beta production (GO:0032728)2.59968063
133regulation of hypersensitivity (GO:0002883)2.58819218
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58000294
135positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57560513
136regulation of interleukin-12 biosynthetic process (GO:0045075)2.56357880
137positive regulation of T cell migration (GO:2000406)2.54590223
138dendritic cell chemotaxis (GO:0002407)2.54154651
139negative regulation of nitric oxide biosynthetic process (GO:0045019)2.52910161
140platelet dense granule organization (GO:0060155)2.52392332
141mature B cell differentiation involved in immune response (GO:0002313)2.50215710
142positive regulation of isotype switching (GO:0045830)2.49915243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.17058555
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.06681497
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.87376901
4E2F7_22180533_ChIP-Seq_HELA_Human4.72605091
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.00935131
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.63534269
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.54487281
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.17628677
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09702901
10* IRF8_27001747_Chip-Seq_BMDM_Mouse3.07594957
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01961559
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92459344
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89185167
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81312351
15SCL_19346495_ChIP-Seq_HPC-7_Human2.75523225
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.71588438
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71279878
18* SPI1_23547873_ChIP-Seq_NB4_Human2.60372588
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.57395706
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.53044991
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.52900331
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48624848
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.45241227
24* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34698948
25* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.05734712
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05116121
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.02359017
28MYB_26560356_Chip-Seq_TH2_Human1.99769460
29* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95591774
30* RUNX1_22412390_ChIP-Seq_EML_Mouse1.93048407
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92629287
32SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92430934
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89894162
34VDR_24763502_ChIP-Seq_THP-1_Human1.83831160
35VDR_21846776_ChIP-Seq_THP-1_Human1.83399303
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.80271447
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77124941
38* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75219430
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.74221007
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69044145
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.68886476
42MYB_26560356_Chip-Seq_TH1_Human1.68405788
43E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67600877
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67284839
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.64737215
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.63370755
47* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62744758
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.62642674
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60501775
50* MAF_26560356_Chip-Seq_TH1_Human1.56999142
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56317867
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.54186266
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48787733
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48003089
55* PU_27001747_Chip-Seq_BMDM_Mouse1.47768200
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.47703613
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46113118
58* VDR_23849224_ChIP-Seq_CD4+_Human1.44396080
59RUNX_20019798_ChIP-Seq_JUKART_Human1.42329995
60* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39042715
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.37050183
62GATA1_22025678_ChIP-Seq_K562_Human1.36712121
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36512018
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.35855469
65BRD4_25478319_ChIP-Seq_HGPS_Human1.35176530
66* ELK1_19687146_ChIP-ChIP_HELA_Human1.34498031
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32466227
68* SPI1_23127762_ChIP-Seq_K562_Human1.32083252
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32050401
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32042703
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.29440419
72MYC_18555785_ChIP-Seq_MESCs_Mouse1.28205202
73UTX_26944678_Chip-Seq_JUKART_Human1.27615326
74MYC_22102868_ChIP-Seq_BL_Human1.27443801
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27036993
76FOXM1_23109430_ChIP-Seq_U2OS_Human1.26485218
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23720307
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23673309
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23139011
80JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22480941
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20632481
82CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.20051781
83KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19091069
84FOXP3_21729870_ChIP-Seq_TREG_Human1.18176665
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17833375
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16777553
87RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16767241
88SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16148948
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.15715737
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15061160
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15061160
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15044439
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.13627668
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10405499
95GATA3_26560356_Chip-Seq_TH2_Human1.10312678
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09922507
97* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08111914
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08066308
99CJUN_26792858_Chip-Seq_BT549_Human1.07780714
100GATA3_27048872_Chip-Seq_THYMUS_Human1.04868822
101MAF_26560356_Chip-Seq_TH2_Human1.04534231
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03753197
103TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03237845
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02249391
105PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01764959
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00840219
107TFEB_21752829_ChIP-Seq_HELA_Human1.00334119
108BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99808505
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99389686
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99151708
111ETS1_20019798_ChIP-Seq_JURKAT_Human0.97348964
112* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95050866
113GATA1_19941827_ChIP-Seq_MEL_Mouse0.93366501
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92628788
115* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92368551
116E2F1_21310950_ChIP-Seq_MCF-7_Human0.91664520
117TCF7_22412390_ChIP-Seq_EML_Mouse0.91101322
118DCP1A_22483619_ChIP-Seq_HELA_Human0.90924238
119STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89629357
120MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88482830
121NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88144112
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88144112
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87997546
124GATA1_19941826_ChIP-Seq_K562_Human0.87841769
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85256639
126VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85054769
127CIITA_25753668_ChIP-Seq_RAJI_Human0.83913402
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82511520
129KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.80385217
130FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80251351
131KDM2B_26808549_Chip-Seq_DND41_Human0.78910785
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78852175
133VDR_24787735_ChIP-Seq_THP-1_Human0.78092413
134GATA2_21666600_ChIP-Seq_HMVEC_Human0.75400404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.75203852
2MP0009785_altered_susceptibility_to3.51797398
3MP0003436_decreased_susceptibility_to3.46545159
4MP0002148_abnormal_hypersensitivity_rea3.29919273
5MP0005671_abnormal_response_to2.98798695
6MP0002419_abnormal_innate_immunity2.96504428
7MP0005000_abnormal_immune_tolerance2.92259627
8MP0005025_abnormal_response_to2.88953026
9MP0008438_abnormal_cutaneous_collagen2.84850967
10MP0000685_abnormal_immune_system2.75366224
11MP0002452_abnormal_antigen_presenting2.64061848
12MP0001790_abnormal_immune_system2.59159518
13MP0005387_immune_system_phenotype2.59159518
14MP0001800_abnormal_humoral_immune2.58738099
15MP0002723_abnormal_immune_serum2.50661628
16MP0002420_abnormal_adaptive_immunity2.43619665
17MP0001819_abnormal_immune_cell2.43524704
18MP0005464_abnormal_platelet_physiology2.42682176
19MP0002396_abnormal_hematopoietic_system2.42409079
20MP0003724_increased_susceptibility_to2.22161700
21MP0005174_abnormal_tail_pigmentation2.21426209
22MP0003303_peritoneal_inflammation2.20858783
23MP0006082_CNS_inflammation2.14940306
24MP0002398_abnormal_bone_marrow2.06797772
25MP0003279_aneurysm2.05356557
26MP0002166_altered_tumor_susceptibility2.04043300
27MP0002405_respiratory_system_inflammati2.02923800
28MP0001853_heart_inflammation2.01793602
29MP0001958_emphysema1.98359699
30MP0003763_abnormal_thymus_physiology1.97764398
31MP0002006_tumorigenesis1.97650855
32MP0000716_abnormal_immune_system1.95700237
33MP0009333_abnormal_splenocyte_physiolog1.92815499
34MP0006054_spinal_hemorrhage1.91886778
35MP0004808_abnormal_hematopoietic_stem1.91255983
36MP0001545_abnormal_hematopoietic_system1.88408123
37MP0005397_hematopoietic_system_phenotyp1.88408123
38MP0010155_abnormal_intestine_physiology1.83793230
39MP0001845_abnormal_inflammatory_respons1.77831843
40MP0000689_abnormal_spleen_morphology1.74008402
41MP0005058_abnormal_lysosome_morphology1.73705153
42MP0003172_abnormal_lysosome_physiology1.67929321
43MP0000490_abnormal_crypts_of1.67836038
44MP0002429_abnormal_blood_cell1.65939560
45MP0002722_abnormal_immune_system1.64740519
46MP0001533_abnormal_skeleton_physiology1.64191725
47MP0000015_abnormal_ear_pigmentation1.62812000
48MP0000858_altered_metastatic_potential1.61610578
49MP0000465_gastrointestinal_hemorrhage1.56751594
50MP0009278_abnormal_bone_marrow1.55245435
51MP0004510_myositis1.52262220
52MP0003693_abnormal_embryo_hatching1.50920392
53MP0009764_decreased_sensitivity_to1.49020754
54MP0005310_abnormal_salivary_gland1.48115892
55MP0001542_abnormal_bone_strength1.46725524
56MP0003091_abnormal_cell_migration1.43638696
57MP0003448_altered_tumor_morphology1.43458091
58MP0005164_abnormal_response_to1.43451938
59MP0005275_abnormal_skin_tensile1.43326182
60MP0008469_abnormal_protein_level1.43325795
61MP0004947_skin_inflammation1.42742633
62MP0003705_abnormal_hypodermis_morpholog1.42124545
63MP0000343_altered_response_to1.40357446
64MP0001873_stomach_inflammation1.39728447
65MP0003566_abnormal_cell_adhesion1.38317675
66MP0005075_abnormal_melanosome_morpholog1.37428852
67MP0004883_abnormal_blood_vessel1.35474510
68MP0005023_abnormal_wound_healing1.27232349
69MP0008058_abnormal_DNA_repair1.26794401
70MP0000703_abnormal_thymus_morphology1.21976985
71MP0003300_gastrointestinal_ulcer1.19779516
72MP0008007_abnormal_cellular_replicative1.18800318
73MP0003866_abnormal_defecation1.18194631
74MP0002095_abnormal_skin_pigmentation1.15900861
75MP0008057_abnormal_DNA_replication1.14763874
76MP0002277_abnormal_respiratory_mucosa1.12571380
77MP0000569_abnormal_digit_pigmentation1.11089011
78MP0010094_abnormal_chromosome_stability1.10793580
79MP0002877_abnormal_melanocyte_morpholog1.08690094
80MP0010307_abnormal_tumor_latency1.08142710
81MP0000604_amyloidosis1.07002749
82MP0003950_abnormal_plasma_membrane1.06980318
83MP0002933_joint_inflammation1.06966713
84MP0003111_abnormal_nucleus_morphology1.04406425
85MP0000767_abnormal_smooth_muscle1.02442670
86MP0002998_abnormal_bone_remodeling1.01454999
87MP0003045_fibrosis0.99734601
88MP0003077_abnormal_cell_cycle0.98275176
89MP0003183_abnormal_peptide_metabolism0.97651909
90* MP0002019_abnormal_tumor_incidence0.95961610
91MP0003186_abnormal_redox_activity0.95280902
92MP0001986_abnormal_taste_sensitivity0.93234780
93MP0000371_diluted_coat_color0.92600567
94MP0005165_increased_susceptibility_to0.92004221
95MP0004782_abnormal_surfactant_physiolog0.91223444
96MP0009763_increased_sensitivity_to0.87232305
97MP0008004_abnormal_stomach_pH0.86915208
98MP0005390_skeleton_phenotype0.84372795
99MP0003806_abnormal_nucleotide_metabolis0.83366663
100MP0002060_abnormal_skin_morphology0.80973962
101MP0002132_abnormal_respiratory_system0.80111439
102MP0003828_pulmonary_edema0.77754764
103MP0003191_abnormal_cellular_cholesterol0.75084578
104MP0002009_preneoplasia0.72342742
105MP0003690_abnormal_glial_cell0.71859511
106MP0005623_abnormal_meninges_morphology0.71655937
107MP0001243_abnormal_dermal_layer0.71394828
108MP0003075_altered_response_to0.71103836
109* MP0000313_abnormal_cell_death0.69106252
110MP0005388_respiratory_system_phenotype0.68984531
111MP0002133_abnormal_respiratory_system0.68984531
112MP0008260_abnormal_autophagy0.68330714
113MP0001851_eye_inflammation0.68324639
114MP0005595_abnormal_vascular_smooth0.66811296
115MP0005451_abnormal_body_composition0.66677636
116MP0003656_abnormal_erythrocyte_physiolo0.66450418
117MP0002332_abnormal_exercise_endurance0.66102930
118MP0010386_abnormal_urinary_bladder0.65102230
119MP0005166_decreased_susceptibility_to0.65010165
120MP0003795_abnormal_bone_structure0.63661257
121MP0000372_irregular_coat_pigmentation0.63114733
122MP0001663_abnormal_digestive_system0.62918938
123MP0003786_premature_aging0.62742699
124MP0000249_abnormal_blood_vessel0.59155484
125MP0009840_abnormal_foam_cell0.58219077
126MP0002075_abnormal_coat/hair_pigmentati0.56345892
127MP0003943_abnormal_hepatobiliary_system0.56144322
128MP0001186_pigmentation_phenotype0.54583020
129MP0000681_abnormal_thyroid_gland0.54031599
130MP0009765_abnormal_xenobiotic_induced0.52722173
131MP0006292_abnormal_olfactory_placode0.52667245

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.07137660
2Eczematoid dermatitis (HP:0000976)5.34569859
3Recurrent bacterial skin infections (HP:0005406)5.29744778
4Myositis (HP:0100614)4.72914878
5Elevated erythrocyte sedimentation rate (HP:0003565)4.53108983
6Abnormality of macrophages (HP:0004311)4.17098454
7Recurrent gram-negative bacterial infections (HP:0005420)3.97613196
8Mediastinal lymphadenopathy (HP:0100721)3.89016496
9Obstructive lung disease (HP:0006536)3.86384907
10Chronic obstructive pulmonary disease (HP:0006510)3.86384907
11Retrobulbar optic neuritis (HP:0100654)3.78884448
12Optic neuritis (HP:0100653)3.78884448
13Orchitis (HP:0100796)3.74884523
14Thrombocytosis (HP:0001894)3.74016034
15Vacuolated lymphocytes (HP:0001922)3.72837753
16Spondylolisthesis (HP:0003302)3.70633411
17Recurrent fungal infections (HP:0002841)3.67907194
18T lymphocytopenia (HP:0005403)3.58669938
19Recurrent skin infections (HP:0001581)3.49845238
20Peritonitis (HP:0002586)3.35946444
21Petechiae (HP:0000967)3.28885002
22IgM deficiency (HP:0002850)3.27506911
23Chronic otitis media (HP:0000389)3.26028657
24Meningitis (HP:0001287)3.23987927
25Gingivitis (HP:0000230)3.20591443
26Recurrent viral infections (HP:0004429)3.20131959
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.12957839
28Chronic mucocutaneous candidiasis (HP:0002728)3.07876549
29Recurrent cutaneous fungal infections (HP:0011370)3.07876549
30Vasculitis (HP:0002633)3.01099006
31Abnormality of the prostate (HP:0008775)3.00644074
32Gastrointestinal infarctions (HP:0005244)2.94385054
33Stomatitis (HP:0010280)2.93823846
34Aortic dissection (HP:0002647)2.91786629
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.91744105
36Autoimmune thrombocytopenia (HP:0001973)2.85404823
37Protrusio acetabuli (HP:0003179)2.83359129
38Dysostosis multiplex (HP:0000943)2.81361274
39Increased cerebral lipofuscin (HP:0011813)2.80582696
40Abnormality of T cell physiology (HP:0011840)2.80276078
41Prostate neoplasm (HP:0100787)2.78961536
42Premature rupture of membranes (HP:0001788)2.76006844
43Basal ganglia calcification (HP:0002135)2.72451275
44Prolonged bleeding time (HP:0003010)2.72397942
45Periodontitis (HP:0000704)2.68870113
46Pustule (HP:0200039)2.61598875
47Chromsome breakage (HP:0040012)2.59758372
48Granulocytopenia (HP:0001913)2.58789236
49Pulmonary infiltrates (HP:0002113)2.57136301
50Cellulitis (HP:0100658)2.56846378
51Amyloidosis (HP:0011034)2.56011761
52Reduced antithrombin III activity (HP:0001976)2.55833716
53Reticulocytopenia (HP:0001896)2.54264981
54Encephalitis (HP:0002383)2.54017731
55Eosinophilia (HP:0001880)2.53786486
56Leukocytosis (HP:0001974)2.53349403
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52238678
58Increased IgM level (HP:0003496)2.50344726
59Recurrent pneumonia (HP:0006532)2.48212021
60Panhypogammaglobulinemia (HP:0003139)2.48118855
61Abnormality of T cells (HP:0002843)2.45178899
62Keratoconjunctivitis sicca (HP:0001097)2.44989980
63Aortic aneurysm (HP:0004942)2.44440019
64Epistaxis (HP:0000421)2.39520864
65Autoimmune hemolytic anemia (HP:0001890)2.38984731
66Dilatation of the ascending aorta (HP:0005111)2.37607325
67Type I transferrin isoform profile (HP:0003642)2.37192944
68Arterial thrombosis (HP:0004420)2.36057834
69Recurrent bronchitis (HP:0002837)2.35394009
70Hemoptysis (HP:0002105)2.34221853
71Gingival bleeding (HP:0000225)2.31444309
72Spontaneous hematomas (HP:0007420)2.30811939
73Agnosia (HP:0010524)2.28250100
74Recurrent lower respiratory tract infections (HP:0002783)2.28195264
75IgG deficiency (HP:0004315)2.28136511
76Inflammation of the large intestine (HP:0002037)2.25287397
77Abnormality of the pericardium (HP:0001697)2.25238673
78Abnormality of eosinophils (HP:0001879)2.24356214
79Hypergammaglobulinemia (HP:0010702)2.23516072
80Albinism (HP:0001022)2.23125974
81Keratoconjunctivitis (HP:0001096)2.22078264
82Spinal cord lesions (HP:0100561)2.21340878
83Syringomyelia (HP:0003396)2.21340878
84Urticaria (HP:0001025)2.19151132
85Cheilitis (HP:0100825)2.18680796
86Vascular tortuosity (HP:0004948)2.17382580
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.16868556
88Abnormality of polysaccharide metabolism (HP:0011012)2.16868556
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.16868556
90Mucopolysacchariduria (HP:0008155)2.16252968
91Urinary glycosaminoglycan excretion (HP:0003541)2.16252968
92Osteomyelitis (HP:0002754)2.16172869
93Clubbing of toes (HP:0100760)2.15687380
94Aplastic anemia (HP:0001915)2.15656389
95Atrophic scars (HP:0001075)2.13370764
96Gastrointestinal inflammation (HP:0004386)2.12612334
97Hematochezia (HP:0002573)2.10947917
98Abnormal platelet function (HP:0011869)2.10749949
99Impaired platelet aggregation (HP:0003540)2.10749949
100Abnormality of the peritoneum (HP:0002585)2.10696868
101Abnormality of glycosphingolipid metabolism (HP:0004343)2.10255692
102Abnormality of glycolipid metabolism (HP:0010969)2.10255692
103Abnormality of liposaccharide metabolism (HP:0010968)2.10255692
104Interstitial pulmonary disease (HP:0006530)2.09713624
105Chest pain (HP:0100749)2.07468456
106Episodic fever (HP:0001954)2.06842497
107Arterial tortuosity (HP:0005116)2.06383763
108Pulmonary embolism (HP:0002204)2.05954374
109Abnormality of cells of the lymphoid lineage (HP:0012140)2.05379190
110Vertebral compression fractures (HP:0002953)2.04168546
111Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.03707323
112Lymphoma (HP:0002665)2.03377383
113Lymphopenia (HP:0001888)2.03145295
114Increased IgE level (HP:0003212)2.03000430
115Thyroiditis (HP:0100646)2.00213909
116Gangrene (HP:0100758)1.99526528
117Chronic diarrhea (HP:0002028)1.98955776
118Abnormality of T cell number (HP:0011839)1.96691511
119Hepatosplenomegaly (HP:0001433)1.96648838
120Acute myeloid leukemia (HP:0004808)1.96295861
121B lymphocytopenia (HP:0010976)1.95402400
122Abnormality of B cell number (HP:0010975)1.95402400
123Myelodysplasia (HP:0002863)1.95119916
124Skin ulcer (HP:0200042)1.94458313
125Glomerulopathy (HP:0100820)1.92831985
126Loss of speech (HP:0002371)1.91985662
127Pulmonary fibrosis (HP:0002206)1.91145431
128Acrocyanosis (HP:0001063)1.90396868
129Agammaglobulinemia (HP:0004432)1.89999564
130Nasal polyposis (HP:0100582)1.89848831
131Abnormality of the pleura (HP:0002103)1.89520599
132Myocardial infarction (HP:0001658)1.89387246
133Neutropenia (HP:0001875)1.88079109
134Abnormal glycosylation (HP:0012345)1.87158615
135Abnormal protein N-linked glycosylation (HP:0012347)1.87158615
136Anorexia (HP:0002039)1.87134751
137Osteolytic defects of the hand bones (HP:0009699)1.86111993
138Osteolytic defects of the phalanges of the hand (HP:0009771)1.86111993
139Cervical subluxation (HP:0003308)1.83662998
140Joint stiffness (HP:0001387)1.83533527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK43.93706161
2IRAK33.62504313
3MAP4K13.11134420
4TXK3.09120288
5KIT2.90683412
6MAP3K142.86188162
7TEC2.67773293
8BLK2.48331260
9TBK12.39594307
10PIM22.25260084
11ZAK2.25242394
12IKBKE2.25147772
13RIPK42.20403711
14NME22.15474616
15IKBKB2.11425903
16JAK32.10555048
17STK162.08275191
18BTK2.04569996
19TYK22.04297438
20GRK71.79539914
21ZAP701.74474121
22TAOK31.73945256
23MAP3K31.67250162
24SYK1.60742255
25PRPF4B1.58424184
26MOS1.51452825
27CSF1R1.44917323
28PIM11.38395640
29MYLK1.37529291
30EIF2AK31.35873050
31RPS6KA41.30249200
32MAP2K31.28496992
33PLK41.27979080
34LYN1.25466491
35ACVR1B1.23975893
36FES1.22155770
37CHUK1.21884216
38EIF2AK21.21679926
39NEK91.19378607
40FLT31.17377332
41HCK1.16027747
42TTN1.14452389
43FGR1.13516122
44JAK11.11750644
45MAP3K121.10830395
46LCK1.09335364
47CLK11.07316542
48EPHB11.07227880
49DDR20.99704332
50TRPM70.99568058
51ITK0.97714673
52STK40.96947313
53MATK0.94795963
54YES10.94609427
55PRKD20.92458251
56PBK0.92203026
57TESK10.89286100
58ADRBK20.87399125
59ATR0.85246828
60MAP3K10.83925982
61WEE10.82081768
62CSK0.81731656
63TGFBR20.81327103
64MAPK70.80166087
65SIK30.79943549
66MAP3K110.78619419
67IRAK10.77590031
68STK100.76243436
69LIMK10.75880331
70NLK0.75736599
71VRK10.75308586
72TNK20.74627809
73SCYL20.69606447
74PIK3CG0.67563842
75CDK60.66847511
76MARK30.66434711
77CDC42BPA0.66304546
78PAK20.65741576
79BUB10.64717119
80TGFBR10.64669510
81TNIK0.64548980
82IRAK20.64178659
83MKNK10.64045294
84KDR0.61982645
85EIF2AK10.60771741
86BMPR20.59402294
87PTK2B0.58380045
88PRKCD0.56321015
89PDGFRB0.55626905
90PRKCQ0.54500495
91FYN0.53275444
92PDK10.53028906
93ABL10.52432270
94TESK20.52273115
95MUSK0.52160745
96ERN10.51889632
97MAP3K130.51205181
98KSR20.50991049
99PDGFRA0.50750435
100RPS6KB20.50716652
101LRRK20.49537024
102BMPR1B0.47765578
103MAP3K50.47761522
104ARAF0.47611364
105CDK40.46571649
106ABL20.44996723
107BRSK20.44750266
108JAK20.44609356
109NEK20.44130709
110RPS6KA60.43770548
111MAPKAPK20.43626303
112MST40.43183135
113SRPK10.41279078
114PRKG20.41278791
115INSR0.40510518
116RAF10.40367830
117CAMKK20.39969811
118CDK80.39013850
119MAP3K20.38993359
120RIPK10.38936401
121CDK70.38900945
122TAOK10.38394155
123NUAK10.38392912
124RPS6KC10.38356492
125RPS6KL10.38356492
126RPS6KA50.38059147
127TAOK20.37441546
128MKNK20.36331620
129MAP3K60.35895485
130SIK20.35798534
131IGF1R0.35743688
132DYRK30.35535178
133MAPK120.35443472
134PDPK10.35272007
135MAP2K60.35249530
136MAPK40.35114204
137PAK40.34900719
138GRK60.34695846
139ERBB30.34689662
140FGFR30.33612268
141CCNB10.33465648
142STK380.33174938
143EGFR0.32719448
144RPS6KA20.32625236

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.76109291
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70988744
3Allograft rejection_Homo sapiens_hsa053302.38429734
4DNA replication_Homo sapiens_hsa030302.36633934
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.34438171
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.13311280
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.12518603
8Graft-versus-host disease_Homo sapiens_hsa053322.11144040
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.10429220
10Measles_Homo sapiens_hsa051622.04861337
11Primary immunodeficiency_Homo sapiens_hsa053402.00112573
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97793839
13Asthma_Homo sapiens_hsa053101.96968523
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85980779
15Osteoclast differentiation_Homo sapiens_hsa043801.85109545
16Other glycan degradation_Homo sapiens_hsa005111.84363294
17Ribosome_Homo sapiens_hsa030101.82085189
18Antigen processing and presentation_Homo sapiens_hsa046121.76847872
19Legionellosis_Homo sapiens_hsa051341.76770620
20Mismatch repair_Homo sapiens_hsa034301.74607047
21Homologous recombination_Homo sapiens_hsa034401.72894774
22Hematopoietic cell lineage_Homo sapiens_hsa046401.66937082
23Pertussis_Homo sapiens_hsa051331.66258089
24Herpes simplex infection_Homo sapiens_hsa051681.65786594
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.65694491
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63936492
27Base excision repair_Homo sapiens_hsa034101.58007184
28Malaria_Homo sapiens_hsa051441.54922464
29Tuberculosis_Homo sapiens_hsa051521.51276513
30Staphylococcus aureus infection_Homo sapiens_hsa051501.46443298
31Influenza A_Homo sapiens_hsa051641.44360786
32B cell receptor signaling pathway_Homo sapiens_hsa046621.42888655
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.35774302
34Lysosome_Homo sapiens_hsa041421.35021222
35Autoimmune thyroid disease_Homo sapiens_hsa053201.33192088
36Apoptosis_Homo sapiens_hsa042101.33160402
37TNF signaling pathway_Homo sapiens_hsa046681.31444337
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29185018
39Shigellosis_Homo sapiens_hsa051311.27226116
40Proteasome_Homo sapiens_hsa030501.26247040
41Fanconi anemia pathway_Homo sapiens_hsa034601.22396194
42Rheumatoid arthritis_Homo sapiens_hsa053231.21929045
43Toxoplasmosis_Homo sapiens_hsa051451.19915783
44Salmonella infection_Homo sapiens_hsa051321.17653055
45Phagosome_Homo sapiens_hsa041451.08658914
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06481927
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.06274474
48Amoebiasis_Homo sapiens_hsa051461.06174739
49Pyrimidine metabolism_Homo sapiens_hsa002401.05464796
50p53 signaling pathway_Homo sapiens_hsa041151.05314690
51Hepatitis B_Homo sapiens_hsa051611.02517505
52Type I diabetes mellitus_Homo sapiens_hsa049401.00176247
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98235120
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97794014
55Nucleotide excision repair_Homo sapiens_hsa034200.97342807
56Chemokine signaling pathway_Homo sapiens_hsa040620.94463818
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93964344
58Non-homologous end-joining_Homo sapiens_hsa034500.93752712
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92908374
60Epstein-Barr virus infection_Homo sapiens_hsa051690.91869385
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90443183
62RNA polymerase_Homo sapiens_hsa030200.89920940
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88495408
64T cell receptor signaling pathway_Homo sapiens_hsa046600.87531974
65Acute myeloid leukemia_Homo sapiens_hsa052210.84812167
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84183043
67Viral myocarditis_Homo sapiens_hsa054160.82006048
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.78474317
69African trypanosomiasis_Homo sapiens_hsa051430.78018595
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76476367
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76392536
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75338280
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74604462
74Focal adhesion_Homo sapiens_hsa045100.72570925
75Spliceosome_Homo sapiens_hsa030400.72354365
76Cell cycle_Homo sapiens_hsa041100.71857690
77Protein export_Homo sapiens_hsa030600.71228032
78Non-small cell lung cancer_Homo sapiens_hsa052230.69179509
79Hepatitis C_Homo sapiens_hsa051600.68844647
80N-Glycan biosynthesis_Homo sapiens_hsa005100.62630035
81Endocytosis_Homo sapiens_hsa041440.62491921
82Viral carcinogenesis_Homo sapiens_hsa052030.62013892
83Platelet activation_Homo sapiens_hsa046110.61458853
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.59449309
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.58878331
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57258100
87Proteoglycans in cancer_Homo sapiens_hsa052050.56558535
88HTLV-I infection_Homo sapiens_hsa051660.56472815
89Bladder cancer_Homo sapiens_hsa052190.55674015
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55155806
91Sphingolipid metabolism_Homo sapiens_hsa006000.54439829
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53991541
93Systemic lupus erythematosus_Homo sapiens_hsa053220.53726069
94Chronic myeloid leukemia_Homo sapiens_hsa052200.53269572
95VEGF signaling pathway_Homo sapiens_hsa043700.53096410
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51886840
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51495961
98One carbon pool by folate_Homo sapiens_hsa006700.51321025
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50647800
100Basal transcription factors_Homo sapiens_hsa030220.49815039
101RNA degradation_Homo sapiens_hsa030180.49778278
102Dorso-ventral axis formation_Homo sapiens_hsa043200.47829387
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47118400
104ECM-receptor interaction_Homo sapiens_hsa045120.46215119
105Renal cell carcinoma_Homo sapiens_hsa052110.45339434
106Pentose phosphate pathway_Homo sapiens_hsa000300.43389545
107Small cell lung cancer_Homo sapiens_hsa052220.43232086
108Pancreatic cancer_Homo sapiens_hsa052120.42777745
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42711199
110Purine metabolism_Homo sapiens_hsa002300.42209364
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.40223062
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35562569
113MAPK signaling pathway_Homo sapiens_hsa040100.35487409
114Renin-angiotensin system_Homo sapiens_hsa046140.35314038
115Arachidonic acid metabolism_Homo sapiens_hsa005900.34400790
116FoxO signaling pathway_Homo sapiens_hsa040680.32285815
117Prolactin signaling pathway_Homo sapiens_hsa049170.31994327
118HIF-1 signaling pathway_Homo sapiens_hsa040660.30566767
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29855303
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.29757553
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29544386
122Rap1 signaling pathway_Homo sapiens_hsa040150.28363323
123GnRH signaling pathway_Homo sapiens_hsa049120.28334452
124Pathways in cancer_Homo sapiens_hsa052000.26414671
125mTOR signaling pathway_Homo sapiens_hsa041500.25019147
126Complement and coagulation cascades_Homo sapiens_hsa046100.24746849
127Ras signaling pathway_Homo sapiens_hsa040140.23151286
128Prostate cancer_Homo sapiens_hsa052150.21592403

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