GLI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lateral sprouting from an epithelium (GO:0060601)5.82151871
2paraxial mesoderm development (GO:0048339)5.04164220
3planar cell polarity pathway involved in neural tube closure (GO:0090179)4.92746653
4regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.66098416
5outer ear morphogenesis (GO:0042473)4.35802050
6presynaptic membrane assembly (GO:0097105)4.10684714
7bone trabecula formation (GO:0060346)4.01624342
8notochord development (GO:0030903)3.88980560
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.84005340
10nuclear pore complex assembly (GO:0051292)3.74488054
11regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.73909710
12mitotic sister chromatid cohesion (GO:0007064)3.63032516
13G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.58991804
14epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.58381739
15Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.56480091
16hippo signaling (GO:0035329)3.56478603
17nuclear pore organization (GO:0006999)3.54394849
18postsynaptic membrane organization (GO:0001941)3.54094731
19olfactory bulb development (GO:0021772)3.50202099
20axon extension involved in axon guidance (GO:0048846)3.48189332
21neuron projection extension involved in neuron projection guidance (GO:1902284)3.48189332
22regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.47710462
23regulation of establishment of planar polarity (GO:0090175)3.46184058
24presynaptic membrane organization (GO:0097090)3.45672664
25chondrocyte proliferation (GO:0035988)3.43789676
26appendage development (GO:0048736)3.43502181
27limb development (GO:0060173)3.43502181
28cochlea morphogenesis (GO:0090103)3.38676444
29neuron fate determination (GO:0048664)3.36166905
30neuronal stem cell maintenance (GO:0097150)3.33570969
31regulation of non-canonical Wnt signaling pathway (GO:2000050)3.31290327
32prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.29891753
33mesenchymal-epithelial cell signaling (GO:0060638)3.27118688
34negative regulation of axon extension involved in axon guidance (GO:0048843)3.26660287
35mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23185534
36body morphogenesis (GO:0010171)3.21270417
37nonmotile primary cilium assembly (GO:0035058)3.20351466
38* cerebral cortex radially oriented cell migration (GO:0021799)3.19188447
39non-canonical Wnt signaling pathway (GO:0035567)3.15248414
40metanephric mesenchyme development (GO:0072075)3.10002360
41dorsal/ventral axis specification (GO:0009950)3.09814474
42convergent extension (GO:0060026)3.09495253
43embryonic body morphogenesis (GO:0010172)3.06541837
44hindlimb morphogenesis (GO:0035137)3.06382908
45apical protein localization (GO:0045176)3.05088409
46embryonic cranial skeleton morphogenesis (GO:0048701)3.03779704
47kinetochore organization (GO:0051383)3.03303494
48axonal fasciculation (GO:0007413)3.03185528
49negative regulation of DNA repair (GO:0045738)2.99923833
50sequestering of extracellular ligand from receptor (GO:0035581)2.99559390
51retinal ganglion cell axon guidance (GO:0031290)2.99066956
52intraciliary transport (GO:0042073)2.97937429
53mitotic metaphase plate congression (GO:0007080)2.97565748
54negative regulation of chondrocyte differentiation (GO:0032331)2.96131045
55middle ear morphogenesis (GO:0042474)2.95798542
56* positive regulation of neuroblast proliferation (GO:0002052)2.95668720
57mesenchymal cell proliferation (GO:0010463)2.95353582
58* cell proliferation in forebrain (GO:0021846)2.95123118
59somite development (GO:0061053)2.93468425
60kidney mesenchyme development (GO:0072074)2.93154590
61otic vesicle formation (GO:0030916)2.93114794
62* craniofacial suture morphogenesis (GO:0097094)2.91003555
63pre-miRNA processing (GO:0031054)2.90860972
64glucocorticoid receptor signaling pathway (GO:0042921)2.90700100
65negative regulation of astrocyte differentiation (GO:0048712)2.89778716
66regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.89195148
67kinetochore assembly (GO:0051382)2.88757711
68* proximal/distal pattern formation (GO:0009954)2.87859989
69heterochromatin organization (GO:0070828)2.87562044
70branching involved in prostate gland morphogenesis (GO:0060442)2.87084852
71embryonic hindlimb morphogenesis (GO:0035116)2.86878327
72embryonic forelimb morphogenesis (GO:0035115)2.84520405
73calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.84147526
74cell proliferation involved in metanephros development (GO:0072203)2.83200665
75lens fiber cell development (GO:0070307)2.77228194
76negative regulation of catenin import into nucleus (GO:0035414)2.76743876
77establishment of planar polarity (GO:0001736)2.76662820
78establishment of tissue polarity (GO:0007164)2.76662820
79regulation of heart morphogenesis (GO:2000826)2.76626809
80embryonic skeletal joint morphogenesis (GO:0060272)2.76077508
81head development (GO:0060322)2.75969637
82spinal cord development (GO:0021510)2.75282810
83forelimb morphogenesis (GO:0035136)2.75056810
84neuron recognition (GO:0008038)2.73518982
85mesenchyme morphogenesis (GO:0072132)2.73030473
86pore complex assembly (GO:0046931)2.71843685
87embryonic limb morphogenesis (GO:0030326)2.70624070
88embryonic appendage morphogenesis (GO:0035113)2.70624070
89neural crest cell development (GO:0014032)2.70578635
90mesenchyme development (GO:0060485)2.69932080
91pyrimidine nucleobase catabolic process (GO:0006208)2.69397838
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.68185883
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.68185883
94regulation of translation, ncRNA-mediated (GO:0045974)2.68185883
95negative chemotaxis (GO:0050919)2.68044828
96mesenchymal cell development (GO:0014031)2.67743303
97metaphase plate congression (GO:0051310)2.67728299
98mitotic chromosome condensation (GO:0007076)2.67660776
99ephrin receptor signaling pathway (GO:0048013)2.66980778
100positive regulation of epithelial to mesenchymal transition (GO:0010718)2.66257943
101regulation of stem cell maintenance (GO:2000036)2.66085647
102regulation of timing of cell differentiation (GO:0048505)2.65692959
103eyelid development in camera-type eye (GO:0061029)2.65566725
104cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64871833
105regulation of sister chromatid cohesion (GO:0007063)2.64771748
106regulation of development, heterochronic (GO:0040034)2.64272868
107* limb morphogenesis (GO:0035108)2.64054756
108* appendage morphogenesis (GO:0035107)2.64054756
109negative regulation of axon guidance (GO:1902668)2.63921830
110* embryonic digit morphogenesis (GO:0042733)2.62978313
111* tongue development (GO:0043586)2.62168176
112regulation of hippo signaling (GO:0035330)2.60384514
113regulation of keratinocyte proliferation (GO:0010837)2.60333921
114negative regulation of keratinocyte proliferation (GO:0010839)2.59724794
115protein localization to kinetochore (GO:0034501)2.58893350
116dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58752826
117collagen fibril organization (GO:0030199)2.58205927
118anterior/posterior axis specification, embryo (GO:0008595)2.56870471
119cerebral cortex development (GO:0021987)2.56698662
120* regulation of smoothened signaling pathway (GO:0008589)2.56546295
121regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.56421343
122pituitary gland development (GO:0021983)2.55288357
123somatic stem cell division (GO:0048103)2.55133097
124digestive tract morphogenesis (GO:0048546)2.55072732
125lung-associated mesenchyme development (GO:0060484)2.54897310
126positive regulation of mesenchymal cell proliferation (GO:0002053)2.54308861
127gastrulation with mouth forming second (GO:0001702)2.52645250
128dermatan sulfate biosynthetic process (GO:0030208)2.52336695
129positive regulation of smoothened signaling pathway (GO:0045880)2.51904625
130asymmetric protein localization (GO:0008105)2.51740905
131negative regulation of embryonic development (GO:0045992)2.50683433
132regulation of mesenchymal cell proliferation (GO:0010464)2.49639774
133anatomical structure regression (GO:0060033)2.49235097
134organ induction (GO:0001759)2.48524450
135facial nerve structural organization (GO:0021612)2.48313597
136limb bud formation (GO:0060174)2.46727132
137cell migration involved in heart development (GO:0060973)2.46626498
138negative regulation of cartilage development (GO:0061037)2.46054774
139renal system development (GO:0072001)2.45840603
140axon extension (GO:0048675)2.45584568
141ganglion development (GO:0061548)2.45218181
142* regulation of neuroblast proliferation (GO:1902692)2.44552595
143cell-cell signaling involved in cell fate commitment (GO:0045168)2.44311275
144developmental induction (GO:0031128)2.44148201
145* smoothened signaling pathway (GO:0007224)2.42968019
146generation of neurons (GO:0048699)2.39598583
147neural tube closure (GO:0001843)2.39236754
148tube closure (GO:0060606)2.38373534
149regulation of axon guidance (GO:1902667)2.37699408
150branching involved in salivary gland morphogenesis (GO:0060445)2.37651794
151* dorsal/ventral pattern formation (GO:0009953)2.37040673
152inner ear morphogenesis (GO:0042472)2.36547471
153post-anal tail morphogenesis (GO:0036342)2.34959414
154somatic stem cell maintenance (GO:0035019)2.34124215
155midbrain development (GO:0030901)2.31889081
156* positive regulation of neural precursor cell proliferation (GO:2000179)2.29070363
157establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.27782939
158lens morphogenesis in camera-type eye (GO:0002089)2.27471250
159regulation of cell fate specification (GO:0042659)2.27266799
160positive regulation of male gonad development (GO:2000020)2.26260242
161central nervous system projection neuron axonogenesis (GO:0021952)2.25261507
162regulation of axon extension involved in axon guidance (GO:0048841)2.23083805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.64614845
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.63626494
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.56679189
4EZH2_22144423_ChIP-Seq_EOC_Human4.37645575
5RBPJ_22232070_ChIP-Seq_NCS_Mouse4.34150455
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.94565408
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.51577329
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83142524
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.71879576
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.48535774
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40173633
12* POU5F1_16153702_ChIP-ChIP_HESCs_Human2.21267200
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20997893
14AR_21909140_ChIP-Seq_LNCAP_Human2.19599483
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18936781
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.13048227
17GBX2_23144817_ChIP-Seq_PC3_Human2.01734323
18* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97309832
19WT1_19549856_ChIP-ChIP_CCG9911_Human1.87327590
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83103939
21* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.83012942
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79491054
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.76814910
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75229151
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.75213964
26* ISL1_27105846_Chip-Seq_CPCs_Mouse1.73770665
27* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73461269
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.70024766
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.69078163
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63974725
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.62878130
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61965993
33* E2F1_21310950_ChIP-Seq_MCF-7_Human1.61183956
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58346487
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56298085
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55858092
37SOX2_18555785_ChIP-Seq_MESCs_Mouse1.55444976
38* PIAS1_25552417_ChIP-Seq_VCAP_Human1.54320051
39TAF15_26573619_Chip-Seq_HEK293_Human1.53320314
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.51435773
41ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.51037801
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.50622157
43FUS_26573619_Chip-Seq_HEK293_Human1.48685356
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.48551715
45* P300_19829295_ChIP-Seq_ESCs_Human1.45611774
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.44174075
47TCF4_18268006_ChIP-ChIP_LS174T_Human1.40852366
48EWS_26573619_Chip-Seq_HEK293_Human1.40326620
49KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.39934952
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39127363
51IGF1R_20145208_ChIP-Seq_DFB_Human1.38117569
52* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.37949284
53BRD4_25478319_ChIP-Seq_HGPS_Human1.36149992
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35942268
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.34140971
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34123305
57* SOX2_16153702_ChIP-ChIP_HESCs_Human1.33542180
58ZNF274_21170338_ChIP-Seq_K562_Hela1.32402830
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32170553
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32170553
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29507829
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26877574
63STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26251594
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25082212
65SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24911680
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24909048
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24443189
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23635096
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23376121
70* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23100777
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.22536302
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21926817
73* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.21078078
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20975290
75* SMAD3_21741376_ChIP-Seq_EPCs_Human1.20353265
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.18996449
77* NANOG_16153702_ChIP-ChIP_HESCs_Human1.18181886
78PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17651631
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17235516
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14565549
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13715547
82* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13355855
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.13249619
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12886936
85ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12319156
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11625340
87* RNF2_27304074_Chip-Seq_ESCs_Mouse1.11282537
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11055096
89RNF2_27304074_Chip-Seq_NSC_Mouse1.09868592
90* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08127914
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07829450
92POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.07608571
93* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07498115
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07449736
95ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07371656
96IRF1_19129219_ChIP-ChIP_H3396_Human1.06704196
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06641382
98SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06233404
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.06054472
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05612151
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.05399357
102* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05343310
103BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05200742
104JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05076266
105* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04439965
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.03861345
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03795610
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03465751
109ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03453204
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03315708
111* EZH2_27294783_Chip-Seq_ESCs_Mouse1.01715135
112* TP53_18474530_ChIP-ChIP_U2OS_Human1.01406417
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01279669
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01218885
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00570469
116TP53_16413492_ChIP-PET_HCT116_Human1.00398669
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99389020
118* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98851035
119AR_21572438_ChIP-Seq_LNCaP_Human0.97658407
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97643153
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97410241
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96846361
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95100056
124KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95100056
125KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95100056
126* AR_25329375_ChIP-Seq_VCAP_Human0.94849379
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94686236
128TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.94415386
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92929216
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92262927
131POU5F1_16518401_ChIP-PET_MESCs_Mouse0.92092911
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.91563329
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90329080
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90329080
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89526551
136HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89387747
137* SOX9_26525672_Chip-Seq_HEART_Mouse0.88363966
138CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88013775
139* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86950944
140ESR1_20079471_ChIP-ChIP_T-47D_Human0.85868014
141NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85633131
142* RING1B_27294783_Chip-Seq_ESCs_Mouse0.83498196
143UBF1/2_26484160_Chip-Seq_HMECs_Human0.81277146
144MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81002147
145* CJUN_26792858_Chip-Seq_BT549_Human0.80634135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010030_abnormal_orbit_morphology3.40186104
2* MP0006292_abnormal_olfactory_placode3.22417596
3MP0005503_abnormal_tendon_morphology2.95669207
4MP0000537_abnormal_urethra_morphology2.73404067
5MP0000049_abnormal_middle_ear2.70527559
6* MP0009053_abnormal_anal_canal2.61647417
7* MP0009250_abnormal_appendicular_skeleto2.56723794
8* MP0003385_abnormal_body_wall2.56206916
9* MP0003937_abnormal_limbs/digits/tail_de2.50893203
10MP0003123_paternal_imprinting2.44965075
11MP0003705_abnormal_hypodermis_morpholog2.30148052
12MP0003942_abnormal_urinary_system2.27808486
13MP0008438_abnormal_cutaneous_collagen2.27254257
14* MP0003755_abnormal_palate_morphology2.25621792
15MP0003122_maternal_imprinting2.09336123
16* MP0000428_abnormal_craniofacial_morphol2.08818286
17MP0003121_genomic_imprinting2.06540438
18* MP0002249_abnormal_larynx_morphology1.95927179
19MP0003935_abnormal_craniofacial_develop1.95664378
20MP0003136_yellow_coat_color1.88286645
21MP0009384_cardiac_valve_regurgitation1.83925826
22MP0002282_abnormal_trachea_morphology1.83468129
23MP0003941_abnormal_skin_development1.82441856
24* MP0002932_abnormal_joint_morphology1.79453661
25* MP0002116_abnormal_craniofacial_bone1.77405076
26MP0003878_abnormal_ear_physiology1.77066791
27MP0005377_hearing/vestibular/ear_phenot1.77066791
28MP0002234_abnormal_pharynx_morphology1.76839728
29* MP0005394_taste/olfaction_phenotype1.76181855
30* MP0005499_abnormal_olfactory_system1.76181855
31* MP0002233_abnormal_nose_morphology1.71329168
32* MP0002938_white_spotting1.68924493
33* MP0000432_abnormal_head_morphology1.66778859
34MP0004272_abnormal_basement_membrane1.64803065
35MP0000534_abnormal_ureter_morphology1.63206076
36MP0000516_abnormal_urinary_system1.60591607
37MP0005367_renal/urinary_system_phenotyp1.60591607
38* MP0005508_abnormal_skeleton_morphology1.58066322
39MP0001299_abnormal_eye_distance/1.55034850
40MP0003115_abnormal_respiratory_system1.53621533
41MP0005257_abnormal_intraocular_pressure1.53161339
42MP0008007_abnormal_cellular_replicative1.53157961
43* MP0001293_anophthalmia1.52149270
44MP0005187_abnormal_penis_morphology1.51161706
45* MP0002109_abnormal_limb_morphology1.50096162
46MP0001346_abnormal_lacrimal_gland1.49527515
47MP0004133_heterotaxia1.47571657
48MP0005275_abnormal_skin_tensile1.45505628
49MP0000762_abnormal_tongue_morphology1.45473995
50* MP0002085_abnormal_embryonic_tissue1.39861661
51MP0003279_aneurysm1.38166321
52* MP0003938_abnormal_ear_development1.37820846
53MP0000733_abnormal_muscle_development1.37447159
54* MP0000631_abnormal_neuroendocrine_gland1.34781928
55MP0003119_abnormal_digestive_system1.34629198
56MP0005076_abnormal_cell_differentiation1.34370978
57MP0002111_abnormal_tail_morphology1.33825482
58MP0010094_abnormal_chromosome_stability1.33409385
59* MP0000026_abnormal_inner_ear1.32134237
60MP0003111_abnormal_nucleus_morphology1.31632400
61* MP0002084_abnormal_developmental_patter1.31493110
62MP0004134_abnormal_chest_morphology1.30903593
63* MP0002177_abnormal_outer_ear1.30393114
64MP0009379_abnormal_foot_pigmentation1.28621999
65* MP0005391_vision/eye_phenotype1.27595410
66MP0005623_abnormal_meninges_morphology1.26771376
67* MP0002114_abnormal_axial_skeleton1.26440613
68MP0003890_abnormal_embryonic-extraembry1.25163683
69MP0000678_abnormal_parathyroid_gland1.23846188
70MP0001286_abnormal_eye_development1.22721264
71MP0003315_abnormal_perineum_morphology1.21945634
72MP0004197_abnormal_fetal_growth/weight/1.20641874
73MP0003077_abnormal_cell_cycle1.20055707
74MP0006072_abnormal_retinal_apoptosis1.19906439
75* MP0000163_abnormal_cartilage_morphology1.19486131
76* MP0002115_abnormal_skeleton_extremities1.19109871
77MP0003880_abnormal_central_pattern1.14675446
78MP0001984_abnormal_olfaction1.14496554
79MP0008932_abnormal_embryonic_tissue1.14360877
80MP0009703_decreased_birth_body1.13862538
81* MP0000566_synostosis1.13275467
82MP0010368_abnormal_lymphatic_system1.12323192
83MP0004885_abnormal_endolymph1.12047523
84* MP0003861_abnormal_nervous_system1.11950012
85MP0001529_abnormal_vocalization1.11647408
86MP0009672_abnormal_birth_weight1.11289819
87MP0000383_abnormal_hair_follicle1.10534879
88* MP0001340_abnormal_eyelid_morphology1.08066182
89MP0003567_abnormal_fetal_cardiomyocyte1.07956574
90MP0004957_abnormal_blastocyst_morpholog1.07293648
91* MP0001672_abnormal_embryogenesis/_devel1.07084758
92* MP0005380_embryogenesis_phenotype1.07084758
93* MP0002092_abnormal_eye_morphology1.06416241
94* MP0005248_abnormal_Harderian_gland1.05701340
95* MP0000579_abnormal_nail_morphology1.05121454
96MP0005171_absent_coat_pigmentation1.04877532
97MP0002653_abnormal_ependyma_morphology1.04677513
98* MP0002113_abnormal_skeleton_development1.03744875
99MP0010352_gastrointestinal_tract_polyps1.03016791
100MP0002108_abnormal_muscle_morphology1.02670344
101MP0001849_ear_inflammation1.01697066
102MP0002152_abnormal_brain_morphology1.01629641
103MP0001177_atelectasis0.99682310
104* MP0002697_abnormal_eye_size0.99260901
105MP0000647_abnormal_sebaceous_gland0.98749436
106* MP0001697_abnormal_embryo_size0.98650551
107* MP0008789_abnormal_olfactory_epithelium0.98415831
108MP0000350_abnormal_cell_proliferation0.98307545
109* MP0002088_abnormal_embryonic_growth/wei0.94523056
110* MP0003984_embryonic_growth_retardation0.94452201
111MP0000767_abnormal_smooth_muscle0.93340782
112* MP0002925_abnormal_cardiovascular_devel0.92464209
113MP0001485_abnormal_pinna_reflex0.92026851
114MP0000955_abnormal_spinal_cord0.89313468
115* MP0005195_abnormal_posterior_eye0.89103263
116MP0002751_abnormal_autonomic_nervous0.88400214
117MP0001730_embryonic_growth_arrest0.88350585
118* MP0002752_abnormal_somatic_nervous0.88256838
119MP0008057_abnormal_DNA_replication0.88015369
120* MP0002081_perinatal_lethality0.87658236
121MP0001915_intracranial_hemorrhage0.87396910
122MP0000778_abnormal_nervous_system0.86817767
123MP0002102_abnormal_ear_morphology0.85435701
124MP0000427_abnormal_hair_cycle0.85194729
125MP0002086_abnormal_extraembryonic_tissu0.84631207
126* MP0005197_abnormal_uvea_morphology0.83513372
127MP0004858_abnormal_nervous_system0.82952494
128MP0005253_abnormal_eye_physiology0.81397746
129MP0003283_abnormal_digestive_organ0.78994046
130* MP0002184_abnormal_innervation0.77175170
131MP0000613_abnormal_salivary_gland0.76700334

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.30360865
2* Short 4th metacarpal (HP:0010044)4.03711896
3* Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.03711896
4Vitreoretinal degeneration (HP:0000655)3.37651351
5Abnormality of the labia minora (HP:0012880)3.24632852
6Hepatoblastoma (HP:0002884)3.20784634
7High anterior hairline (HP:0009890)3.12901741
8* Abnormality of the 4th metacarpal (HP:0010012)3.11594244
9Septo-optic dysplasia (HP:0100842)3.10691803
10Short 1st metacarpal (HP:0010034)2.99907516
11Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.99907516
12Abnormality of the parietal bone (HP:0002696)2.96303239
13Midline defect of the nose (HP:0004122)2.94816717
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.91600313
15Protrusio acetabuli (HP:0003179)2.89515959
16Short middle phalanx of the 5th finger (HP:0004220)2.70926210
17Hypoplastic labia majora (HP:0000059)2.69863265
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.67568338
19Partial duplication of thumb phalanx (HP:0009944)2.64507808
20Short phalanx of the thumb (HP:0009660)2.62121604
21Coronal craniosynostosis (HP:0004440)2.58822948
22Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.55730453
23Abnormality of the 1st metacarpal (HP:0010009)2.54517762
24Syringomyelia (HP:0003396)2.50942834
25Spinal cord lesions (HP:0100561)2.50942834
26Alacrima (HP:0000522)2.49343123
27* Broad toe (HP:0001837)2.45927658
28Abnormality of the nasal septum (HP:0000419)2.45421348
29Abnormality of the labia majora (HP:0012881)2.44414414
30Abnormality of the ischium (HP:0003174)2.40212575
31Hypoplastic ischia (HP:0003175)2.38341137
32* Broad thumb (HP:0011304)2.37231582
33Fibular hypoplasia (HP:0003038)2.36047358
34Mesomelia (HP:0003027)2.32878463
35Selective tooth agenesis (HP:0001592)2.32559959
36Abnormality of the antihelix (HP:0009738)2.32529876
37Renal duplication (HP:0000075)2.31377800
38Cutaneous finger syndactyly (HP:0010554)2.29642397
39Anophthalmia (HP:0000528)2.28440292
40Short 5th finger (HP:0009237)2.26437820
41Esophageal atresia (HP:0002032)2.25562137
42Increased density of long bones (HP:0006392)2.25368469
43Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.25026247
44Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.24419428
45* Abnormality of the phalanges of the hallux (HP:0010057)2.23297159
46Colon cancer (HP:0003003)2.22595091
47Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19344583
48Long clavicles (HP:0000890)2.17680902
49Cutaneous syndactyly (HP:0012725)2.16719592
50True hermaphroditism (HP:0010459)2.15932891
51* Broad hallux (HP:0010055)2.15393081
52Nephronophthisis (HP:0000090)2.14236006
53Abnormality of the phalanges of the 5th finger (HP:0004213)2.14060677
54Decreased lacrimation (HP:0000633)2.13295274
55Abnormality of the middle phalanges of the toes (HP:0010183)2.13085643
56* Abnormality of the distal phalanx of the thumb (HP:0009617)2.12962255
57Abnormality of the pubic bones (HP:0003172)2.12853985
58Optic nerve hypoplasia (HP:0000609)2.12468344
59Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.11676831
60Tracheomalacia (HP:0002779)2.11622428
61Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09965550
62Premature rupture of membranes (HP:0001788)2.09716491
63* Trigonocephaly (HP:0000243)2.09699589
64Broad ribs (HP:0000885)2.08893696
65Morphological abnormality of the middle ear (HP:0008609)2.08592391
66Gastrointestinal atresia (HP:0002589)2.08051392
67Neonatal short-limb short stature (HP:0008921)2.06791833
68* Broad long bones (HP:0005622)2.06469219
69Abnormal number of incisors (HP:0011064)2.06277945
70Wide cranial sutures (HP:0010537)2.06271935
71Abnormality of the 2nd finger (HP:0004100)2.06121141
72Broad metatarsal (HP:0001783)2.05930423
73Hypoplastic pelvis (HP:0008839)2.05245259
74Aplasia involving bones of the upper limbs (HP:0009823)2.02664109
75Aplasia of the phalanges of the hand (HP:0009802)2.02664109
76Aplasia involving bones of the extremities (HP:0009825)2.02664109
77Abnormality of cochlea (HP:0000375)2.00669064
78Pancreatic fibrosis (HP:0100732)1.99939687
79* Broad phalanges of the hand (HP:0009768)1.99560094
80Synostosis of carpal bones (HP:0005048)1.98901737
81* Preaxial foot polydactyly (HP:0001841)1.98763645
82Absent septum pellucidum (HP:0001331)1.96135671
83Deviation of the hallux (HP:0010051)1.95885298
84* Broad phalanx (HP:0006009)1.94999308
85Abnormality of the proximal phalanges of the hand (HP:0009834)1.94818197
86Oligodactyly (hands) (HP:0001180)1.94520331
87Abnormality of the nasolacrimal system (HP:0000614)1.94171953
88Asymmetry of the thorax (HP:0001555)1.93432972
89* Broad finger (HP:0001500)1.93127106
90Wide anterior fontanel (HP:0000260)1.91749050
91* Facial hemangioma (HP:0000329)1.91714839
92Choanal stenosis (HP:0000452)1.91705876
93Long eyelashes (HP:0000527)1.89180146
94Morphological abnormality of the inner ear (HP:0011390)1.88866157
95Supernumerary ribs (HP:0005815)1.88545356
96Intestinal atresia (HP:0011100)1.88110546
97Ankle contracture (HP:0006466)1.86623525
98Duplication of thumb phalanx (HP:0009942)1.86116017
99Hydroureter (HP:0000072)1.85937461
100Turricephaly (HP:0000262)1.85789331
101Abnormality of the lacrimal duct (HP:0011481)1.84008246
102Abnormality of the incisor (HP:0000676)1.83916585
103Short hallux (HP:0010109)1.83548091
104Aqueductal stenosis (HP:0002410)1.82925941
105* Postaxial hand polydactyly (HP:0001162)1.82227282
106Hypoplasia of the maxilla (HP:0000327)1.82087309
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81479772
108Short middle phalanx of finger (HP:0005819)1.79966001
109Carpal synostosis (HP:0009702)1.79742034
110Bifid tongue (HP:0010297)1.79043949
111Genital tract atresia (HP:0001827)1.78849617
112Soft skin (HP:0000977)1.77652337
113Abnormality of the middle phalanges of the hand (HP:0009833)1.77624952
114Increased number of teeth (HP:0011069)1.76561941
115Thin ribs (HP:0000883)1.76531413
116Narrow palate (HP:0000189)1.76168284
117Aplasia/Hypoplasia of the patella (HP:0006498)1.75883162
118Molar tooth sign on MRI (HP:0002419)1.75313860
119Abnormality of midbrain morphology (HP:0002418)1.75313860
120Labial hypoplasia (HP:0000066)1.74651761
121Bronchomalacia (HP:0002780)1.74482232
122Aplasia/Hypoplasia of the fibula (HP:0006492)1.73333101
123* Renal hypoplasia (HP:0000089)1.73270605
124Vaginal atresia (HP:0000148)1.73045878
125Hallux valgus (HP:0001822)1.72694024
126Increased nuchal translucency (HP:0010880)1.72413821
127Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.72230606
128Vertebral hypoplasia (HP:0008417)1.72230606
129Supernumerary bones of the axial skeleton (HP:0009144)1.71528530
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.71222374
131Absent epiphyses (HP:0010577)1.71222374
132Patellar aplasia (HP:0006443)1.71195107
133Down-sloping shoulders (HP:0200021)1.70559069
134Aplasia/Hypoplasia of the breasts (HP:0010311)1.70444452
135Hypoplasia of the ulna (HP:0003022)1.70435458
136Vertebral clefting (HP:0008428)1.70086563
137* Postaxial foot polydactyly (HP:0001830)1.70064212
138Dislocated radial head (HP:0003083)1.69665897
139Abnormality of the renal medulla (HP:0100957)1.69185925
140Broad foot (HP:0001769)1.68972503
141Hypoplastic female external genitalia (HP:0012815)1.68852992
142Bell-shaped thorax (HP:0001591)1.68449611
143* Atresia of the external auditory canal (HP:0000413)1.68324510
144Abnormality of the septum pellucidum (HP:0007375)1.67935504
145Tented upper lip vermilion (HP:0010804)1.67644078
146Nasolacrimal duct obstruction (HP:0000579)1.67243406
147Partial duplication of the phalanx of hand (HP:0009999)1.66112719
148Ureteral obstruction (HP:0006000)1.66095326
149Wormian bones (HP:0002645)1.65992831
150Occipital encephalocele (HP:0002085)1.65956581
151* Preaxial hand polydactyly (HP:0001177)1.65864133
152Shawl scrotum (HP:0000049)1.65717806
153Ureteral stenosis (HP:0000071)1.65482030
154Abnormality of abdominal situs (HP:0011620)1.65158672
155Abdominal situs inversus (HP:0003363)1.65158672
156Anencephaly (HP:0002323)1.64572429
157Abnormality of the radial head (HP:0003995)1.64076976
158Cystic liver disease (HP:0006706)1.63601621
159Congenital primary aphakia (HP:0007707)1.61855337
160Short ribs (HP:0000773)1.60991336
161Gait imbalance (HP:0002141)1.60971889
162Abnormality of dentin (HP:0010299)1.60719060
163Supernumerary spleens (HP:0009799)1.58855807

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS16.16028812
2CDC73.43450137
3LATS23.37649077
4STK38L3.31610439
5EPHB23.16063093
6MKNK12.91376985
7CDK122.82588561
8DDR22.78612652
9MKNK22.58096455
10STK32.42552873
11NUAK12.22942568
12PNCK2.19196594
13WNK32.05087054
14PLK41.99556210
15TNIK1.81915258
16PDGFRA1.71200896
17SRPK11.66229542
18MAP4K21.62701968
19ERBB31.61617001
20FGFR21.60575165
21BRD41.59779243
22NTRK11.54245242
23SIK11.51000576
24FGFR11.47457138
25NEK21.46140650
26TTK1.42336346
27NTRK21.41502732
28MARK11.39201397
29PLK31.32234696
30EPHA31.31851775
31CHEK21.27361084
32TYRO31.26137091
33CDK81.23669345
34CDK71.23515962
35RPS6KA41.16452358
36TAF11.15499653
37MAPK151.15011913
38PRKD31.14298835
39VRK21.07574722
40MAP3K41.06831022
41BRSK21.04353638
42PLK11.01805355
43CDK61.00156512
44TTN0.98835518
45ATR0.98078649
46MTOR0.95995467
47MAP3K100.94168751
48BMX0.94010858
49BUB10.93735948
50SGK4940.93411927
51SGK2230.93411927
52BCR0.93192423
53PRKD20.92643962
54WEE10.91263922
55NEK90.91102945
56DMPK0.87601862
57AURKB0.86234541
58CHEK10.85286478
59NLK0.84699747
60CDK90.84134213
61CAMK1D0.83804109
62ATM0.82410935
63STK240.82192442
64MELK0.81165392
65CAMK1G0.81040687
66TRIB30.79653229
67PLK20.79214476
68AKT30.78228184
69TGFBR10.77044950
70PAK20.75084465
71CLK10.74672150
72ERBB20.74321840
73BMPR1B0.74025844
74SGK20.73482438
75CDK20.73312155
76CDK40.73137567
77CDK10.72551564
78PAK60.72502758
79CSNK1A1L0.66782194
80TRIM280.66567960
81EIF2AK20.65484526
82DYRK20.63474985
83CSNK1G10.61665125
84PDGFRB0.61142292
85EPHA40.61080305
86STK380.61039374
87MAP2K70.60489690
88PAK30.60057358
89CASK0.59857938
90STK390.59794419
91MET0.59195465
92PTK20.58840507
93ACVR1B0.58791921
94VRK10.58567405
95ROCK10.57723991
96WNK40.56648161
97ERBB40.56568234
98MAPK130.55554673
99CDK30.51269398
100KSR10.50836068
101CSNK1G20.50603326
102MAPK140.50559341
103INSRR0.49441458
104UHMK10.49299980
105DYRK30.49239943
106PAK40.49210207
107DYRK1A0.47536543
108ROCK20.46925363
109BRSK10.46103165
110TLK10.45925938
111CSNK1G30.45390981
112PTK60.45332016
113PRKCE0.44820377
114GSK3B0.44736032
115ZAK0.44588333
116AKT10.43827209
117SGK30.43218513
118CDK190.43208672
119TSSK60.42797142
120MAP3K80.42021878
121AKT20.40109674
122FRK0.39141030
123MAPK100.38926934
124MAPK10.38920571
125PASK0.37270738
126CDK11A0.36880704
127CDK180.36676371
128CDK150.36390337
129PRKCG0.35968254
130PKN10.34797034
131STK40.33289818
132FER0.32911751
133CAMK40.32557731
134PRKDC0.32260671
135AURKA0.32065232
136CSNK1E0.31564159
137CHUK0.30562748
138PIK3CA0.30050129

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.62241710
2Cell cycle_Homo sapiens_hsa041102.99180339
3Hippo signaling pathway_Homo sapiens_hsa043902.74057875
4* Hedgehog signaling pathway_Homo sapiens_hsa043402.62428019
5TGF-beta signaling pathway_Homo sapiens_hsa043502.51873419
6Adherens junction_Homo sapiens_hsa045202.44243008
7Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.33554454
8MicroRNAs in cancer_Homo sapiens_hsa052062.16819542
9Spliceosome_Homo sapiens_hsa030402.11354616
10Wnt signaling pathway_Homo sapiens_hsa043102.11080542
11RNA transport_Homo sapiens_hsa030132.01641292
12DNA replication_Homo sapiens_hsa030301.95732962
13Steroid biosynthesis_Homo sapiens_hsa001001.85855029
14mRNA surveillance pathway_Homo sapiens_hsa030151.77942603
15ECM-receptor interaction_Homo sapiens_hsa045121.74625124
16Homologous recombination_Homo sapiens_hsa034401.70666472
17Proteoglycans in cancer_Homo sapiens_hsa052051.69484338
18Prostate cancer_Homo sapiens_hsa052151.67842076
19p53 signaling pathway_Homo sapiens_hsa041151.67482797
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67352044
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66132717
22Protein export_Homo sapiens_hsa030601.65447580
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65086674
24Mismatch repair_Homo sapiens_hsa034301.60852927
25Axon guidance_Homo sapiens_hsa043601.60474191
26Fanconi anemia pathway_Homo sapiens_hsa034601.59559843
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.57177646
28Basal transcription factors_Homo sapiens_hsa030221.57058185
29RNA degradation_Homo sapiens_hsa030181.54572345
30Colorectal cancer_Homo sapiens_hsa052101.53241591
31Melanogenesis_Homo sapiens_hsa049161.52483827
32Notch signaling pathway_Homo sapiens_hsa043301.47834880
33One carbon pool by folate_Homo sapiens_hsa006701.44987107
34Small cell lung cancer_Homo sapiens_hsa052221.44775931
35Base excision repair_Homo sapiens_hsa034101.42244744
36Thyroid cancer_Homo sapiens_hsa052161.41124495
37Melanoma_Homo sapiens_hsa052181.40842384
38Focal adhesion_Homo sapiens_hsa045101.38371435
39HTLV-I infection_Homo sapiens_hsa051661.36004948
40* Pathways in cancer_Homo sapiens_hsa052001.34560557
41Endometrial cancer_Homo sapiens_hsa052131.32026549
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22788524
43Nucleotide excision repair_Homo sapiens_hsa034201.21407391
44Lysine degradation_Homo sapiens_hsa003101.21243199
45Chronic myeloid leukemia_Homo sapiens_hsa052201.20576904
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19615860
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19253747
48Oocyte meiosis_Homo sapiens_hsa041141.19022755
49Bladder cancer_Homo sapiens_hsa052191.13298420
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12919553
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10256226
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09902801
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05373971
54Propanoate metabolism_Homo sapiens_hsa006401.04561911
55Tight junction_Homo sapiens_hsa045301.03809201
56Non-homologous end-joining_Homo sapiens_hsa034501.01358167
57Viral myocarditis_Homo sapiens_hsa054160.99858937
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98381788
59RNA polymerase_Homo sapiens_hsa030200.97985003
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97515579
61Cocaine addiction_Homo sapiens_hsa050300.95039000
62Rap1 signaling pathway_Homo sapiens_hsa040150.88636399
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88269028
64Pancreatic cancer_Homo sapiens_hsa052120.87351161
65Protein digestion and absorption_Homo sapiens_hsa049740.86937789
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86752277
67Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86516093
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83736557
69Dorso-ventral axis formation_Homo sapiens_hsa043200.82568356
70Phototransduction_Homo sapiens_hsa047440.79778029
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79034787
72Renal cell carcinoma_Homo sapiens_hsa052110.78984908
73Viral carcinogenesis_Homo sapiens_hsa052030.78648352
74FoxO signaling pathway_Homo sapiens_hsa040680.78641846
75Glioma_Homo sapiens_hsa052140.78510258
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74782381
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73788648
78Herpes simplex infection_Homo sapiens_hsa051680.72217494
79Ribosome_Homo sapiens_hsa030100.71572307
80Dilated cardiomyopathy_Homo sapiens_hsa054140.70708127
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70518404
82Thyroid hormone synthesis_Homo sapiens_hsa049180.68767901
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66432822
84Hepatitis B_Homo sapiens_hsa051610.63598775
85Folate biosynthesis_Homo sapiens_hsa007900.62308655
86Non-small cell lung cancer_Homo sapiens_hsa052230.61036879
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60728040
88ErbB signaling pathway_Homo sapiens_hsa040120.60095240
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59439638
90mTOR signaling pathway_Homo sapiens_hsa041500.58275648
91Gap junction_Homo sapiens_hsa045400.57289399
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56895928
93Epstein-Barr virus infection_Homo sapiens_hsa051690.56590059
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.55955641
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55644689
96Amoebiasis_Homo sapiens_hsa051460.54243224
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.53908131
98Ovarian steroidogenesis_Homo sapiens_hsa049130.53663708
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.53379465
100Pyrimidine metabolism_Homo sapiens_hsa002400.53129174
101Nicotine addiction_Homo sapiens_hsa050330.52930156
102Ras signaling pathway_Homo sapiens_hsa040140.51806993
103Systemic lupus erythematosus_Homo sapiens_hsa053220.47777932
104Vitamin B6 metabolism_Homo sapiens_hsa007500.47326329
105Circadian entrainment_Homo sapiens_hsa047130.46976984
106MAPK signaling pathway_Homo sapiens_hsa040100.46880399
107Alcoholism_Homo sapiens_hsa050340.44538302
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43446302
109Choline metabolism in cancer_Homo sapiens_hsa052310.43360653
110Huntingtons disease_Homo sapiens_hsa050160.42076055
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42048110
112Circadian rhythm_Homo sapiens_hsa047100.41093663
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40901919
114* cAMP signaling pathway_Homo sapiens_hsa040240.40791625
115Nitrogen metabolism_Homo sapiens_hsa009100.40759019
116Insulin secretion_Homo sapiens_hsa049110.40741489
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40399765
118Butanoate metabolism_Homo sapiens_hsa006500.39578324
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39518403
120Dopaminergic synapse_Homo sapiens_hsa047280.39392760
121Estrogen signaling pathway_Homo sapiens_hsa049150.39193515
122Glutamatergic synapse_Homo sapiens_hsa047240.38598137
123Malaria_Homo sapiens_hsa051440.38388122
124Amphetamine addiction_Homo sapiens_hsa050310.36424648
125Fatty acid elongation_Homo sapiens_hsa000620.35901756
126Cholinergic synapse_Homo sapiens_hsa047250.35721735
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34578370
128AMPK signaling pathway_Homo sapiens_hsa041520.32855061
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32630531
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.32295801
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.31915955
132Cardiac muscle contraction_Homo sapiens_hsa042600.31644318
133HIF-1 signaling pathway_Homo sapiens_hsa040660.30735471
134Ether lipid metabolism_Homo sapiens_hsa005650.30369062
135Biosynthesis of amino acids_Homo sapiens_hsa012300.30152287
136GnRH signaling pathway_Homo sapiens_hsa049120.28625274
137Shigellosis_Homo sapiens_hsa051310.28267438
138Purine metabolism_Homo sapiens_hsa002300.27222000

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