GLI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.06777950
2regulation of posttranscriptional gene silencing (GO:0060147)4.68848272
3regulation of gene silencing by miRNA (GO:0060964)4.68848272
4regulation of gene silencing by RNA (GO:0060966)4.68848272
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.55766514
6pre-miRNA processing (GO:0031054)4.50525397
7establishment of apical/basal cell polarity (GO:0035089)4.43615852
8regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.26874478
9anterior/posterior axis specification, embryo (GO:0008595)4.01345790
10polarized epithelial cell differentiation (GO:0030859)3.98197940
11notochord development (GO:0030903)3.91997828
12heterochromatin organization (GO:0070828)3.81995832
13establishment of monopolar cell polarity (GO:0061162)3.77296186
14establishment or maintenance of monopolar cell polarity (GO:0061339)3.77296186
15convergent extension (GO:0060026)3.76064645
16nuclear pore organization (GO:0006999)3.57225165
17bone trabecula formation (GO:0060346)3.52152607
18nuclear pore complex assembly (GO:0051292)3.50302834
19DNA unwinding involved in DNA replication (GO:0006268)3.48921677
20chromatin remodeling at centromere (GO:0031055)3.48146263
21regulation of hippo signaling (GO:0035330)3.47166554
22protein localization to kinetochore (GO:0034501)3.45068705
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44409032
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.44409032
25mitotic sister chromatid segregation (GO:0000070)3.39356131
26positive regulation of SMAD protein import into nucleus (GO:0060391)3.37013516
27regulation of sister chromatid cohesion (GO:0007063)3.36507628
28negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31864149
29regulation of cell fate specification (GO:0042659)3.30147792
30negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.28345991
31regulation of translational fidelity (GO:0006450)3.27502618
32generation of neurons (GO:0048699)3.27412341
33DNA replication-dependent nucleosome organization (GO:0034723)3.26964411
34DNA replication-dependent nucleosome assembly (GO:0006335)3.26964411
35embryonic camera-type eye development (GO:0031076)3.26748217
36sister chromatid segregation (GO:0000819)3.23188692
37CENP-A containing nucleosome assembly (GO:0034080)3.21656079
38histone H4-K12 acetylation (GO:0043983)3.21438578
39establishment of integrated proviral latency (GO:0075713)3.14894881
40Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.14419409
41hippo signaling (GO:0035329)3.14096340
42regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.12198949
43outer ear morphogenesis (GO:0042473)3.11227205
44non-canonical Wnt signaling pathway (GO:0035567)3.05631887
45regulation of establishment of planar polarity (GO:0090175)3.02978479
46presynaptic membrane assembly (GO:0097105)3.02550286
47histone arginine methylation (GO:0034969)3.01608909
48negative regulation of mRNA processing (GO:0050686)3.00816804
49hindlimb morphogenesis (GO:0035137)2.99789900
50proline biosynthetic process (GO:0006561)2.99320186
51intracellular estrogen receptor signaling pathway (GO:0030520)2.99032403
52mitotic nuclear envelope disassembly (GO:0007077)2.98095688
53replication fork processing (GO:0031297)2.97147742
54lung-associated mesenchyme development (GO:0060484)2.96837030
55regulation of double-strand break repair (GO:2000779)2.96164582
56regulation of SMAD protein import into nucleus (GO:0060390)2.96023156
57craniofacial suture morphogenesis (GO:0097094)2.94387352
58neural tube closure (GO:0001843)2.93867934
59* lateral sprouting from an epithelium (GO:0060601)2.92299643
60DNA duplex unwinding (GO:0032508)2.91697519
61tube closure (GO:0060606)2.91630222
62embryonic process involved in female pregnancy (GO:0060136)2.91590390
63DNA geometric change (GO:0032392)2.91079001
64embryonic hindlimb morphogenesis (GO:0035116)2.90547789
65regulation of RNA export from nucleus (GO:0046831)2.89504321
66L-serine metabolic process (GO:0006563)2.87455955
67trophectodermal cell differentiation (GO:0001829)2.86817904
68regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.83286561
69establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.83137818
70chondrocyte proliferation (GO:0035988)2.82611636
71chromatin assembly (GO:0031497)2.81029567
72transcription from mitochondrial promoter (GO:0006390)2.80910284
73peptidyl-arginine omega-N-methylation (GO:0035247)2.80812557
74mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.79844878
75neuron projection extension involved in neuron projection guidance (GO:1902284)2.78745369
76axon extension involved in axon guidance (GO:0048846)2.78745369
77DNA replication-independent nucleosome organization (GO:0034724)2.78513495
78DNA replication-independent nucleosome assembly (GO:0006336)2.78513495
79mitotic metaphase plate congression (GO:0007080)2.78212412
80formation of translation preinitiation complex (GO:0001731)2.77877074
81nuclear envelope disassembly (GO:0051081)2.76631229
82membrane disassembly (GO:0030397)2.76631229
83spliceosomal tri-snRNP complex assembly (GO:0000244)2.75833233
84G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.75670263
85apoptotic process involved in morphogenesis (GO:0060561)2.73974648
86kinetochore organization (GO:0051383)2.73058281
87regulation of non-canonical Wnt signaling pathway (GO:2000050)2.73001458
88inner ear receptor cell development (GO:0060119)2.72827714
89establishment of tissue polarity (GO:0007164)2.72729619
90establishment of planar polarity (GO:0001736)2.72729619
91somatic stem cell division (GO:0048103)2.72606669
92negative regulation of DNA repair (GO:0045738)2.72255561
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.70772137
94negative regulation of androgen receptor signaling pathway (GO:0060766)2.70459114
95histone H4-K8 acetylation (GO:0043982)2.70053116
96histone H4-K5 acetylation (GO:0043981)2.70053116
97regulation of stem cell maintenance (GO:2000036)2.69880629
98dorsal/ventral axis specification (GO:0009950)2.68854135
99histone exchange (GO:0043486)2.68470095
100cranial suture morphogenesis (GO:0060363)2.68310248
101regulation of gene silencing (GO:0060968)2.66532593
102* anatomical structure regression (GO:0060033)2.65448990
103nodal signaling pathway (GO:0038092)2.65420917
104mitotic chromosome condensation (GO:0007076)2.63620094
105dosage compensation (GO:0007549)2.63521515
106protein heterotrimerization (GO:0070208)2.62916470
107positive regulation of chromosome segregation (GO:0051984)2.62193232
108positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.62176555
109positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.62176555
110positive regulation of mitotic sister chromatid separation (GO:1901970)2.62176555
111negative regulation of histone methylation (GO:0031061)2.61443589
112protein localization to chromosome, centromeric region (GO:0071459)2.61141142
113DNA strand elongation involved in DNA replication (GO:0006271)2.59888904
114negative regulation of RNA splicing (GO:0033119)2.59809414
115regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.58940992
116mitotic sister chromatid cohesion (GO:0007064)2.58089385
117embryonic placenta development (GO:0001892)2.57958015
118bone morphogenesis (GO:0060349)2.57788652
119determination of adult lifespan (GO:0008340)2.57297188
120kinetochore assembly (GO:0051382)2.56601854
121regulation of telomere maintenance via telomerase (GO:0032210)2.55053027
122protein complex localization (GO:0031503)2.54835035
123collagen fibril organization (GO:0030199)2.54573850
124body morphogenesis (GO:0010171)2.53908205
125mesenchymal cell proliferation (GO:0010463)2.53398763
126DNA replication initiation (GO:0006270)2.52638331
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.52516584
128negative regulation of mRNA metabolic process (GO:1903312)2.52486937
129ventricular cardiac muscle cell development (GO:0055015)2.51069178
130ATP-dependent chromatin remodeling (GO:0043044)2.50360462
131metaphase plate congression (GO:0051310)2.49691747
132presynaptic membrane organization (GO:0097090)2.49614095
133DNA strand elongation (GO:0022616)2.48285438
134negative regulation of cell fate specification (GO:0009996)2.47394861
135DNA replication checkpoint (GO:0000076)2.46710451
136* cochlea morphogenesis (GO:0090103)2.45571694
137mesenchymal to epithelial transition (GO:0060231)2.44988124
138postsynaptic membrane organization (GO:0001941)2.44194019
139endothelial cell morphogenesis (GO:0001886)2.41554833
140prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.40119156
141negative regulation of embryonic development (GO:0045992)2.39965269
142mesenchymal-epithelial cell signaling (GO:0060638)2.38799507
143kidney mesenchyme development (GO:0072074)2.37231870
144cell migration involved in sprouting angiogenesis (GO:0002042)2.34909262
145branching involved in salivary gland morphogenesis (GO:0060445)2.34681228
146negative regulation of chromosome segregation (GO:0051985)2.33473565
147negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.33353693
148negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.33353693
149negative regulation of mitotic sister chromatid segregation (GO:0033048)2.33353693
150negative regulation of mitotic sister chromatid separation (GO:2000816)2.33353693
151negative regulation of sister chromatid segregation (GO:0033046)2.33353693
152regulation of cell fate commitment (GO:0010453)2.31814961
153neuronal stem cell maintenance (GO:0097150)2.29384750
154establishment of viral latency (GO:0019043)2.29137951
155regulation of mitotic spindle organization (GO:0060236)2.27733639
156DNA damage response, detection of DNA damage (GO:0042769)2.26017220
157establishment or maintenance of apical/basal cell polarity (GO:0035088)2.25622546
158establishment or maintenance of bipolar cell polarity (GO:0061245)2.25622546
159cell proliferation in forebrain (GO:0021846)2.25000057
160regulation of gastrulation (GO:0010470)2.24770962
161olfactory bulb development (GO:0021772)2.24754785
162chromatin assembly or disassembly (GO:0006333)2.24701190
163cellular protein complex localization (GO:0034629)2.24460640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70503420
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.41025739
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.41025739
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.41025739
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.83541694
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.34983495
7* SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.26545996
8* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.17960437
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.06332998
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.02992641
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.76729367
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.73941592
13* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.69498642
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.69304576
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.63836075
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62595886
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.54783308
18* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.49499209
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.45576867
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42511976
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.39541538
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22485185
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14336761
24POU5F1_16518401_ChIP-PET_MESCs_Mouse2.09526236
25SOX2_18555785_ChIP-Seq_MESCs_Mouse2.08456264
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06152804
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05364250
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.02156500
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02047257
30POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00621689
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99503664
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.86635995
33* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86270041
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.83205736
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.82523108
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.81177389
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.79715929
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78454675
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73149449
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72731373
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.72605437
42* NANOG_21062744_ChIP-ChIP_HESCs_Human1.72274728
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69969872
44EZH2_22144423_ChIP-Seq_EOC_Human1.67450620
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66271385
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62905732
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62146747
48TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.60419757
49NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.58576243
50KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.57408872
51MYC_22102868_ChIP-Seq_BL_Human1.53985963
52EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53751271
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46273505
54AR_21909140_ChIP-Seq_LNCAP_Human1.45022302
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43691423
56POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.41348318
57* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.40891734
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40866438
59* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40144373
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.39519953
61* ISL1_27105846_Chip-Seq_CPCs_Mouse1.38593527
62* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.37550879
63NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35886562
64HIF1A_21447827_ChIP-Seq_MCF-7_Human1.35830025
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35641691
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.35395463
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.34348889
68* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.34291230
69TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.32328351
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30912713
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28486819
72NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.28466710
73RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27555933
74FUS_26573619_Chip-Seq_HEK293_Human1.27388057
75* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27303534
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26815286
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25011227
78* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24220466
79* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23534740
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22990321
81GATA1_26923725_Chip-Seq_HPCs_Mouse1.22000088
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20792236
83SOX9_26525672_Chip-Seq_HEART_Mouse1.20356608
84* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.20335834
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20153008
86EWS_26573619_Chip-Seq_HEK293_Human1.19883683
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19241575
88HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18167535
89NANOG_16518401_ChIP-PET_MESCs_Mouse1.17209749
90WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16895226
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16364160
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15060607
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.14973879
94* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14781942
95XRN2_22483619_ChIP-Seq_HELA_Human1.14738862
96* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13739662
97* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13284626
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.13150485
99KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13008868
100EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08703616
101RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08703616
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08461869
103TP53_20018659_ChIP-ChIP_R1E_Mouse1.08171752
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.08054025
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07013159
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.06986215
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06505187
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.06298836
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04290747
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03486817
111RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03407599
112* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02999771
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02066395
114GBX2_23144817_ChIP-Seq_PC3_Human1.01990235
115ELK1_19687146_ChIP-ChIP_HELA_Human1.01757435
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.01742894
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00414140
118* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00396600
119MYC_18940864_ChIP-ChIP_HL60_Human1.00266901
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.99178647
121* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91730931
122ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91318676
123ELK3_25401928_ChIP-Seq_HUVEC_Human0.90171971
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89815643
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88843402
126P300_19829295_ChIP-Seq_ESCs_Human0.88666251
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88634128
128EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88442759
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87620160
130P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86847103
131TTF2_22483619_ChIP-Seq_HELA_Human0.85884486
132* KAP1_27257070_Chip-Seq_ESCs_Mouse0.85826979
133KDM2B_26808549_Chip-Seq_DND41_Human0.85552748
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84927445
135* RING1B_27294783_Chip-Seq_NPCs_Mouse0.84429606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.20900501
2MP0008057_abnormal_DNA_replication2.98336847
3MP0003705_abnormal_hypodermis_morpholog2.71572243
4MP0002653_abnormal_ependyma_morphology2.52350969
5MP0009053_abnormal_anal_canal2.51200467
6MP0002249_abnormal_larynx_morphology2.32761971
7MP0001293_anophthalmia2.27068123
8MP0001299_abnormal_eye_distance/2.09586459
9MP0004957_abnormal_blastocyst_morpholog2.08582431
10MP0003123_paternal_imprinting2.08302108
11MP0003890_abnormal_embryonic-extraembry2.01059334
12MP0005076_abnormal_cell_differentiation1.99644727
13MP0010094_abnormal_chromosome_stability1.98600376
14MP0003111_abnormal_nucleus_morphology1.93437818
15MP0010352_gastrointestinal_tract_polyps1.91711381
16MP0003385_abnormal_body_wall1.89779664
17MP0003283_abnormal_digestive_organ1.88639523
18MP0003119_abnormal_digestive_system1.87336563
19MP0000537_abnormal_urethra_morphology1.87171003
20MP0004133_heterotaxia1.86898680
21MP0003136_yellow_coat_color1.83463012
22MP0000428_abnormal_craniofacial_morphol1.83311569
23* MP0002085_abnormal_embryonic_tissue1.79718432
24MP0003937_abnormal_limbs/digits/tail_de1.75199475
25* MP0002084_abnormal_developmental_patter1.75117278
26MP0004197_abnormal_fetal_growth/weight/1.74306280
27* MP0003755_abnormal_palate_morphology1.74041963
28MP0003122_maternal_imprinting1.73760981
29* MP0000049_abnormal_middle_ear1.71280315
30MP0003941_abnormal_skin_development1.69879901
31MP0002254_reproductive_system_inflammat1.67322541
32MP0006292_abnormal_olfactory_placode1.67153321
33MP0008438_abnormal_cutaneous_collagen1.66170638
34MP0003121_genomic_imprinting1.65763301
35MP0003077_abnormal_cell_cycle1.64613969
36MP0003942_abnormal_urinary_system1.62322878
37MP0009250_abnormal_appendicular_skeleto1.62085799
38MP0002938_white_spotting1.60688589
39MP0005503_abnormal_tendon_morphology1.60591258
40MP0000762_abnormal_tongue_morphology1.60459637
41* MP0002932_abnormal_joint_morphology1.60328243
42MP0005380_embryogenesis_phenotype1.59486147
43MP0001672_abnormal_embryogenesis/_devel1.59486147
44* MP0003935_abnormal_craniofacial_develop1.59316175
45MP0002282_abnormal_trachea_morphology1.58786524
46* MP0000432_abnormal_head_morphology1.53721351
47MP0000350_abnormal_cell_proliferation1.49087552
48MP0000566_synostosis1.47638967
49MP0009384_cardiac_valve_regurgitation1.45829052
50MP0000778_abnormal_nervous_system1.45318747
51* MP0002116_abnormal_craniofacial_bone1.43137676
52MP0002086_abnormal_extraembryonic_tissu1.42471433
53MP0002111_abnormal_tail_morphology1.41776848
54MP0001849_ear_inflammation1.40198673
55MP0002088_abnormal_embryonic_growth/wei1.38962839
56MP0003984_embryonic_growth_retardation1.38928148
57MP0001730_embryonic_growth_arrest1.38467148
58MP0005248_abnormal_Harderian_gland1.37722895
59MP0005623_abnormal_meninges_morphology1.37393593
60MP0004233_abnormal_muscle_weight1.37037059
61* MP0001697_abnormal_embryo_size1.36973874
62MP0008932_abnormal_embryonic_tissue1.36908081
63MP0000534_abnormal_ureter_morphology1.32747486
64MP0002092_abnormal_eye_morphology1.30880461
65MP0009379_abnormal_foot_pigmentation1.29790277
66MP0009672_abnormal_birth_weight1.29473098
67MP0003567_abnormal_fetal_cardiomyocyte1.28502324
68* MP0005508_abnormal_skeleton_morphology1.26163149
69MP0004272_abnormal_basement_membrane1.25970128
70MP0000516_abnormal_urinary_system1.24556706
71MP0005367_renal/urinary_system_phenotyp1.24556706
72MP0002233_abnormal_nose_morphology1.24538964
73* MP0002114_abnormal_axial_skeleton1.23366536
74MP0003115_abnormal_respiratory_system1.22517219
75MP0000733_abnormal_muscle_development1.22491013
76MP0002697_abnormal_eye_size1.20603218
77MP0004264_abnormal_extraembryonic_tissu1.19810419
78MP0005275_abnormal_skin_tensile1.18453867
79MP0003693_abnormal_embryo_hatching1.16059212
80MP0000579_abnormal_nail_morphology1.14691933
81MP0001958_emphysema1.13289865
82MP0009703_decreased_birth_body1.11354966
83MP0001346_abnormal_lacrimal_gland1.10992301
84MP0003938_abnormal_ear_development1.10871972
85MP0005257_abnormal_intraocular_pressure1.10810247
86MP0009278_abnormal_bone_marrow1.08859182
87MP0008007_abnormal_cellular_replicative1.08686137
88* MP0003861_abnormal_nervous_system1.08574416
89MP0008058_abnormal_DNA_repair1.05732187
90* MP0002080_prenatal_lethality1.05041589
91* MP0002109_abnormal_limb_morphology1.03219992
92* MP0001286_abnormal_eye_development1.03154251
93MP0000631_abnormal_neuroendocrine_gland1.02157412
94MP0005187_abnormal_penis_morphology1.00493321
95MP0001529_abnormal_vocalization0.99857228
96MP0002925_abnormal_cardiovascular_devel0.99791900
97MP0000462_abnormal_digestive_system0.99023872
98MP0001340_abnormal_eyelid_morphology0.98589611
99MP0000678_abnormal_parathyroid_gland0.97151248
100MP0002108_abnormal_muscle_morphology0.95678567
101MP0008789_abnormal_olfactory_epithelium0.94143699
102MP0005394_taste/olfaction_phenotype0.93692058
103MP0005499_abnormal_olfactory_system0.93692058
104MP0010307_abnormal_tumor_latency0.93125705
105MP0009697_abnormal_copulation0.92163677
106MP0003566_abnormal_cell_adhesion0.91921865
107MP0002751_abnormal_autonomic_nervous0.90484063
108MP0010368_abnormal_lymphatic_system0.89613530
109* MP0002081_perinatal_lethality0.89126355
110MP0003878_abnormal_ear_physiology0.85996073
111MP0005377_hearing/vestibular/ear_phenot0.85996073
112MP0005391_vision/eye_phenotype0.85834863
113MP0002177_abnormal_outer_ear0.85565702
114MP0001177_atelectasis0.83392662
115MP0003315_abnormal_perineum_morphology0.83172905
116MP0005023_abnormal_wound_healing0.83099908
117MP0004134_abnormal_chest_morphology0.82978493
118MP0003279_aneurysm0.82386504
119MP0005197_abnormal_uvea_morphology0.82050270
120* MP0000163_abnormal_cartilage_morphology0.81045366
121MP0005171_absent_coat_pigmentation0.80863736
122MP0004858_abnormal_nervous_system0.80595472
123MP0006072_abnormal_retinal_apoptosis0.79387233
124MP0001188_hyperpigmentation0.76123434

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.92133990
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.92133990
3Abnormality of the 4th metacarpal (HP:0010012)3.86534493
4Rib fusion (HP:0000902)3.73837896
5Septo-optic dysplasia (HP:0100842)3.68668539
6Abnormality of the labia minora (HP:0012880)3.11818999
7Shallow orbits (HP:0000586)3.06017237
8Neoplasm of the oral cavity (HP:0100649)3.05639211
9Ependymoma (HP:0002888)2.98746879
10Medulloblastoma (HP:0002885)2.88261030
11Supernumerary ribs (HP:0005815)2.84244780
12Coronal craniosynostosis (HP:0004440)2.81274207
13Renal duplication (HP:0000075)2.81203279
14Neonatal short-limb short stature (HP:0008921)2.74754327
15Astrocytoma (HP:0009592)2.71327048
16Abnormality of the astrocytes (HP:0100707)2.71327048
17Rectovaginal fistula (HP:0000143)2.67049193
18Rectal fistula (HP:0100590)2.67049193
19Partial duplication of thumb phalanx (HP:0009944)2.65360723
20Neoplasm of striated muscle (HP:0009728)2.64113238
21Supernumerary bones of the axial skeleton (HP:0009144)2.61972559
22Broad thumb (HP:0011304)2.61287793
23Short humerus (HP:0005792)2.59417750
24Intestinal fistula (HP:0100819)2.57514563
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.57426974
26Trigonocephaly (HP:0000243)2.57396774
27Abnormality of the parietal bone (HP:0002696)2.55125992
28Short phalanx of the thumb (HP:0009660)2.54035943
29Protrusio acetabuli (HP:0003179)2.53028739
30Abnormality of dentin (HP:0010299)2.51753806
31Aplasia/hypoplasia of the humerus (HP:0006507)2.50436737
32Broad toe (HP:0001837)2.48824827
33Soft skin (HP:0000977)2.46710011
34Ectopic kidney (HP:0000086)2.45901820
35Glioma (HP:0009733)2.45227815
36Facial hemangioma (HP:0000329)2.43371458
37Bilateral microphthalmos (HP:0007633)2.41251376
38Turricephaly (HP:0000262)2.38789086
39Hemivertebrae (HP:0002937)2.38544102
40Bowel diverticulosis (HP:0005222)2.33772690
41Duplication of thumb phalanx (HP:0009942)2.33549623
42Short 5th finger (HP:0009237)2.31519836
43Ankle contracture (HP:0006466)2.30828789
44Hepatoblastoma (HP:0002884)2.30814805
45Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.29767010
46Shawl scrotum (HP:0000049)2.27435279
47Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.26752011
48Abnormality of the diencephalon (HP:0010662)2.25562348
49Preaxial foot polydactyly (HP:0001841)2.24477477
50Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.24150972
51Midline defect of the nose (HP:0004122)2.21352260
52Vaginal fistula (HP:0004320)2.21291359
53Abnormality of the phalanges of the hallux (HP:0010057)2.20620947
54Vertebral fusion (HP:0002948)2.16792714
55Atresia of the external auditory canal (HP:0000413)2.13481481
56Neoplasm of the heart (HP:0100544)2.12755776
57Broad phalanges of the hand (HP:0009768)2.11785601
58Absent radius (HP:0003974)2.09063739
59Morphological abnormality of the middle ear (HP:0008609)2.09034000
60Wide anterior fontanel (HP:0000260)2.08614045
61Choanal stenosis (HP:0000452)2.08432922
62Broad hallux (HP:0010055)2.08284028
63Supernumerary spleens (HP:0009799)2.07953903
64Ulnar bowing (HP:0003031)2.07877541
65Absent forearm bone (HP:0003953)2.06833681
66Aplasia involving forearm bones (HP:0009822)2.06833681
67Concave nail (HP:0001598)2.06452720
68Absent septum pellucidum (HP:0001331)2.06451790
69Rhabdomyosarcoma (HP:0002859)2.04785520
70Esophageal atresia (HP:0002032)2.04712560
71Aortic dissection (HP:0002647)2.01287512
72Skin tags (HP:0010609)2.00090851
73Large earlobe (HP:0009748)1.99948233
74Maternal diabetes (HP:0009800)1.98941659
75Abnormality of abdominal situs (HP:0011620)1.98941326
76Abdominal situs inversus (HP:0003363)1.98941326
77Vitreoretinal degeneration (HP:0000655)1.98540002
78Broad finger (HP:0001500)1.98388991
79Colon cancer (HP:0003003)1.98115352
80Partial duplication of the phalanx of hand (HP:0009999)1.96828961
81Increased nuchal translucency (HP:0010880)1.95274695
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.94704920
83Overriding aorta (HP:0002623)1.94437468
84Cutaneous finger syndactyly (HP:0010554)1.94118617
85Anteriorly placed anus (HP:0001545)1.92763136
86Broad long bones (HP:0005622)1.92761115
87Intestinal atresia (HP:0011100)1.91775501
88Broad phalanx (HP:0006009)1.91003714
89Cutaneous syndactyly (HP:0012725)1.90848379
90Abnormality of the pubic bones (HP:0003172)1.90333622
91Abnormality of the middle phalanges of the toes (HP:0010183)1.90131096
92High anterior hairline (HP:0009890)1.89929384
93Calcaneovalgus deformity (HP:0001848)1.89424165
94Patellar aplasia (HP:0006443)1.89306029
95Cortical dysplasia (HP:0002539)1.88856664
96Short hallux (HP:0010109)1.87114719
97Pseudobulbar signs (HP:0002200)1.86934326
98Mitral valve prolapse (HP:0001634)1.86635756
99Abnormality of the septum pellucidum (HP:0007375)1.85642955
100Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.85514769
101Short 1st metacarpal (HP:0010034)1.85514769
102Hypoplastic ischia (HP:0003175)1.85150508
103Missing ribs (HP:0000921)1.84795451
104Hypoplastic labia majora (HP:0000059)1.84428645
105Bronchomalacia (HP:0002780)1.83899385
106Arnold-Chiari malformation (HP:0002308)1.82666566
107Short middle phalanx of the 5th finger (HP:0004220)1.81998896
108Deviation of the hallux (HP:0010051)1.81304742
109Abnormal lung lobation (HP:0002101)1.81277480
110Mesomelia (HP:0003027)1.81004967
111Aplasia/Hypoplasia of the patella (HP:0006498)1.80779831
112Meckel diverticulum (HP:0002245)1.77860823
113Bifid tongue (HP:0010297)1.75899290
114Abnormality of the aortic arch (HP:0012303)1.75823939
115Gastrointestinal atresia (HP:0002589)1.75572565
116Preauricular skin tag (HP:0000384)1.73857565
117Annular pancreas (HP:0001734)1.73794255
118Deformed tarsal bones (HP:0008119)1.73003408
119Increased number of teeth (HP:0011069)1.72898118
120Aplasia/Hypoplasia of the hallux (HP:0008362)1.72333490
121Abnormality of the calcaneus (HP:0008364)1.72268378
122Reticulocytopenia (HP:0001896)1.71932442
123Nephroblastoma (Wilms tumor) (HP:0002667)1.70436385
124Elfin facies (HP:0004428)1.69991355
125Broad metatarsal (HP:0001783)1.69799445
126Bladder diverticulum (HP:0000015)1.69786909
127* Abnormal number of incisors (HP:0011064)1.69702118
128Abnormality of the ileum (HP:0001549)1.69548096
129Volvulus (HP:0002580)1.69382260
130Oligodactyly (HP:0012165)1.69315965
131Synostosis of carpal bones (HP:0005048)1.68714525
132Ectopic anus (HP:0004397)1.68504509
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68348326
134Down-sloping shoulders (HP:0200021)1.67604450
135Renal hypoplasia (HP:0000089)1.66713681
136Biconcave vertebral bodies (HP:0004586)1.65924794
137Genu recurvatum (HP:0002816)1.65729149
138Facial cleft (HP:0002006)1.65267755
139Embryonal renal neoplasm (HP:0011794)1.65010697
140Cerebral aneurysm (HP:0004944)1.64799715
141Premature rupture of membranes (HP:0001788)1.64571961
142Abnormality of the nasal septum (HP:0000419)1.64527753
143Skull defect (HP:0001362)1.64503905
144Vertebral arch anomaly (HP:0008438)1.64089370
145Sparse lateral eyebrow (HP:0005338)1.64048400
146Omphalocele (HP:0001539)1.63959204
147Camptodactyly of toe (HP:0001836)1.63833810
148Aplasia/Hypoplasia of the breasts (HP:0010311)1.63460446
149Renovascular hypertension (HP:0100817)1.63123632
150Atrophic scars (HP:0001075)1.59660188
151Aqueductal stenosis (HP:0002410)1.59580740
152Fragile skin (HP:0001030)1.58615113
153* Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57622038
154Aplasia involving bones of the extremities (HP:0009825)1.57557700
155Aplasia involving bones of the upper limbs (HP:0009823)1.57557700
156Aplasia of the phalanges of the hand (HP:0009802)1.57557700
157Thin ribs (HP:0000883)1.56093118
158Triphalangeal thumb (HP:0001199)1.55032113
159* Optic nerve hypoplasia (HP:0000609)1.53303866
160Aortic aneurysm (HP:0004942)1.52229025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.30462045
2DDR23.83021843
3ICK3.53799683
4TNIK3.44871276
5LATS12.91551997
6LATS22.81498139
7CDC72.69039074
8PDGFRA2.38684952
9CDK72.30926432
10MAP3K102.25788274
11VRK22.24953188
12TYRO32.22745689
13TTK2.02076963
14BMX1.84258803
15AKT31.81481568
16PLK41.68882273
17BRD41.68018713
18NEK21.65864727
19EPHA21.59159858
20TAF11.59011586
21MTOR1.56234417
22CHEK21.54643118
23WEE11.51742029
24RPS6KB21.49649413
25PBK1.46962393
26NEK11.46656948
27NTRK11.45882176
28EPHB21.43739928
29SIK11.41982240
30PLK11.40998789
31FGFR11.33391994
32WNK31.30591523
33CDK61.25942954
34MKNK11.23936044
35BRSK21.22528801
36TRIB31.19335819
37MATK1.18122355
38STK38L1.18107747
39CDK191.17155432
40CASK1.17076126
41ATR1.16871410
42PAK41.16121934
43BCR1.15483183
44CHEK11.14979034
45MAP3K61.14276229
46VRK11.11284387
47* DYRK21.10807653
48ERBB41.09431700
49CDK41.08812503
50MKNK21.07770297
51STK31.07620535
52ZAK1.06579474
53RIPK11.04457405
54ALK1.03760455
55MYLK1.03667506
56MET1.03048525
57BUB11.00307176
58EEF2K0.98414995
59CDK20.97940204
60CSNK1G10.97103419
61DYRK30.96159514
62NUAK10.92748887
63MAPK150.89950970
64PRKD20.86289030
65STK100.86123479
66LIMK10.85693218
67ATM0.85691749
68CDK90.85463451
69NLK0.85290250
70CAMK1D0.83946908
71NME10.82544709
72PLK20.81934498
73FGR0.80922536
74EPHA40.79163993
75PAK20.79142153
76MAP3K40.78999464
77AURKB0.78915648
78TTN0.76822020
79PRKCI0.76518295
80UHMK10.76266081
81PTK20.76010242
82CDC42BPA0.75188695
83CDK80.74470205
84DYRK1B0.74368032
85CDK10.74170820
86AKT20.73771607
87MAP3K80.73466542
88CSNK1A1L0.73334500
89CSNK1G30.70130215
90MARK10.68499330
91YES10.68129250
92BRSK10.67780035
93ERN10.67475148
94TSSK60.67461690
95MAP2K70.67151581
96PLK30.65670918
97FGFR20.65454194
98SMG10.65267791
99AURKA0.64461632
100CSNK1G20.64326723
101PDGFRB0.62667074
102CSNK1E0.59867622
103PIM10.59039252
104* MAPK10.58460096
105MAPK140.58428943
106FLT30.58154655
107PKN20.55667512
108PRKD30.54781409
109TAOK20.54205185
110ERBB20.53794240
111CAMK1G0.53723706
112SRPK10.53494650
113PNCK0.52989397
114TRIM280.52533657
115PASK0.51744781
116GRK10.50970318
117GSK3B0.50847383
118GSK3A0.49455594
119MAP3K110.49309566
120TGFBR10.48895291
121AKT10.48315579
122EIF2AK20.47974166
123MAPK100.47209276
124ROCK10.47189045
125CDK11A0.46888100
126STK40.46508243
127TESK20.46480995
128CSNK1D0.45684868
129CAMK40.45594057
130PRKCG0.45360712
131PRKDC0.44791406
132RPS6KC10.44087295
133RPS6KL10.44087295
134DYRK1A0.43746837
135RPS6KA10.43385723
136CDK150.42353670
137ROCK20.41798072
138CDK30.41627785
139CDK180.40878154
140PAK10.40764864
141CSK0.40645708
142PRKCE0.40149763
143MAPK70.39864368
144DMPK0.38589923
145MELK0.37624576
146STK380.37300309
147DAPK10.36043759

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.67944359
2* Basal cell carcinoma_Homo sapiens_hsa052173.52504144
3DNA replication_Homo sapiens_hsa030303.23133412
4* Hedgehog signaling pathway_Homo sapiens_hsa043402.94598999
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73659860
6RNA transport_Homo sapiens_hsa030132.69355023
7Spliceosome_Homo sapiens_hsa030402.66454013
8Base excision repair_Homo sapiens_hsa034102.61905614
9* Hippo signaling pathway_Homo sapiens_hsa043902.51517604
10Cell cycle_Homo sapiens_hsa041102.49463868
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.35239461
12mRNA surveillance pathway_Homo sapiens_hsa030152.30663927
13Notch signaling pathway_Homo sapiens_hsa043302.05436668
14Adherens junction_Homo sapiens_hsa045202.01143587
15One carbon pool by folate_Homo sapiens_hsa006701.95376461
16TGF-beta signaling pathway_Homo sapiens_hsa043501.92436845
17Wnt signaling pathway_Homo sapiens_hsa043101.84312912
18MicroRNAs in cancer_Homo sapiens_hsa052061.81982966
19Fanconi anemia pathway_Homo sapiens_hsa034601.80961517
20Nucleotide excision repair_Homo sapiens_hsa034201.79241133
21Homologous recombination_Homo sapiens_hsa034401.74011584
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.63612239
23p53 signaling pathway_Homo sapiens_hsa041151.62256057
24Fatty acid biosynthesis_Homo sapiens_hsa000611.59549755
25mTOR signaling pathway_Homo sapiens_hsa041501.50271070
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48720698
27Lysine degradation_Homo sapiens_hsa003101.47545126
28Proteoglycans in cancer_Homo sapiens_hsa052051.37772233
29Bladder cancer_Homo sapiens_hsa052191.35151341
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32632065
31RNA degradation_Homo sapiens_hsa030181.26901319
32Colorectal cancer_Homo sapiens_hsa052101.24916241
33ECM-receptor interaction_Homo sapiens_hsa045121.23269595
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18264755
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17033713
36* Pathways in cancer_Homo sapiens_hsa052001.17014328
37Small cell lung cancer_Homo sapiens_hsa052221.16282176
38Oocyte meiosis_Homo sapiens_hsa041141.10034660
39Thyroid cancer_Homo sapiens_hsa052161.09872890
40Tight junction_Homo sapiens_hsa045301.09343068
41Steroid biosynthesis_Homo sapiens_hsa001001.08948664
42HTLV-I infection_Homo sapiens_hsa051661.06433259
43Protein export_Homo sapiens_hsa030601.04686310
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.03756425
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.03312454
46Biosynthesis of amino acids_Homo sapiens_hsa012301.03033407
47Focal adhesion_Homo sapiens_hsa045101.02947058
48Vitamin B6 metabolism_Homo sapiens_hsa007500.99484500
49Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98723170
50Melanoma_Homo sapiens_hsa052180.96473106
51Prostate cancer_Homo sapiens_hsa052150.92945322
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91256194
53Huntingtons disease_Homo sapiens_hsa050160.90999470
54Non-homologous end-joining_Homo sapiens_hsa034500.90367758
55Melanogenesis_Homo sapiens_hsa049160.90339108
56RNA polymerase_Homo sapiens_hsa030200.88955357
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87829340
58Basal transcription factors_Homo sapiens_hsa030220.87199269
59Proteasome_Homo sapiens_hsa030500.86114646
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.85360627
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84504793
62Viral carcinogenesis_Homo sapiens_hsa052030.84244587
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82863146
64Protein digestion and absorption_Homo sapiens_hsa049740.82677637
65Chronic myeloid leukemia_Homo sapiens_hsa052200.81994619
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81635679
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81522074
68Endometrial cancer_Homo sapiens_hsa052130.79833926
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78643603
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78352197
71Purine metabolism_Homo sapiens_hsa002300.78159786
72Viral myocarditis_Homo sapiens_hsa054160.72713507
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72604049
74Dorso-ventral axis formation_Homo sapiens_hsa043200.70988063
75Cardiac muscle contraction_Homo sapiens_hsa042600.70055948
76Axon guidance_Homo sapiens_hsa043600.68434434
77Ribosome_Homo sapiens_hsa030100.64952609
78Fructose and mannose metabolism_Homo sapiens_hsa000510.64136792
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63141763
80Rap1 signaling pathway_Homo sapiens_hsa040150.61536452
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59616743
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57274258
83Nitrogen metabolism_Homo sapiens_hsa009100.57151163
84AMPK signaling pathway_Homo sapiens_hsa041520.56532992
85Parkinsons disease_Homo sapiens_hsa050120.54796066
86Cocaine addiction_Homo sapiens_hsa050300.52669878
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51846695
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50279955
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49780767
90Nicotine addiction_Homo sapiens_hsa050330.48665102
91Pyruvate metabolism_Homo sapiens_hsa006200.48427874
92Sulfur relay system_Homo sapiens_hsa041220.48105064
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48066881
94Pyrimidine metabolism_Homo sapiens_hsa002400.48000303
95Epstein-Barr virus infection_Homo sapiens_hsa051690.46774436
96Herpes simplex infection_Homo sapiens_hsa051680.46346564
97Glutathione metabolism_Homo sapiens_hsa004800.46037009
98ErbB signaling pathway_Homo sapiens_hsa040120.45818267
99Folate biosynthesis_Homo sapiens_hsa007900.44985978
100Gap junction_Homo sapiens_hsa045400.42944244
101Phototransduction_Homo sapiens_hsa047440.42583268
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40534646
103Glioma_Homo sapiens_hsa052140.40460555
104Systemic lupus erythematosus_Homo sapiens_hsa053220.39488529
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39076116
106Non-small cell lung cancer_Homo sapiens_hsa052230.38984904
107HIF-1 signaling pathway_Homo sapiens_hsa040660.38957998
108Acute myeloid leukemia_Homo sapiens_hsa052210.38813347
109Alcoholism_Homo sapiens_hsa050340.38118956
110Thyroid hormone synthesis_Homo sapiens_hsa049180.35231935
111Propanoate metabolism_Homo sapiens_hsa006400.35141568
112Selenocompound metabolism_Homo sapiens_hsa004500.35022655
113Pancreatic cancer_Homo sapiens_hsa052120.34330231
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34095975
115Choline metabolism in cancer_Homo sapiens_hsa052310.33949469
116Arginine and proline metabolism_Homo sapiens_hsa003300.32632714
117Dilated cardiomyopathy_Homo sapiens_hsa054140.32076155
118Renal cell carcinoma_Homo sapiens_hsa052110.31994111
119Insulin signaling pathway_Homo sapiens_hsa049100.31798352
120VEGF signaling pathway_Homo sapiens_hsa043700.31189646
121Oxidative phosphorylation_Homo sapiens_hsa001900.30617551
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30466633
123Estrogen signaling pathway_Homo sapiens_hsa049150.29453357
124MAPK signaling pathway_Homo sapiens_hsa040100.29411362
125Taste transduction_Homo sapiens_hsa047420.28770356
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28638612
127Galactose metabolism_Homo sapiens_hsa000520.28412450
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.27253599
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26718933
130Amoebiasis_Homo sapiens_hsa051460.25809563
131Alzheimers disease_Homo sapiens_hsa050100.25343577
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24861242
133cAMP signaling pathway_Homo sapiens_hsa040240.23556742

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