GK5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)4.91707287
2behavioral response to nicotine (GO:0035095)4.37316342
3histone H2B ubiquitination (GO:0033523)4.17073860
4protein K6-linked ubiquitination (GO:0085020)4.13110877
5neural tube formation (GO:0001841)4.10720898
6cilium or flagellum-dependent cell motility (GO:0001539)4.09095800
7fucose catabolic process (GO:0019317)4.06063400
8L-fucose metabolic process (GO:0042354)4.06063400
9L-fucose catabolic process (GO:0042355)4.06063400
10tryptophan catabolic process (GO:0006569)4.03169699
11indole-containing compound catabolic process (GO:0042436)4.03169699
12indolalkylamine catabolic process (GO:0046218)4.03169699
13cell fate commitment involved in formation of primary germ layer (GO:0060795)3.88792109
14regulation of mRNA 3-end processing (GO:0031440)3.80951712
15positive regulation of mRNA 3-end processing (GO:0031442)3.80136969
16protein K11-linked deubiquitination (GO:0035871)3.76533136
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73070800
18interkinetic nuclear migration (GO:0022027)3.70239634
19indolalkylamine metabolic process (GO:0006586)3.70191938
20establishment of protein localization to Golgi (GO:0072600)3.65831645
21kynurenine metabolic process (GO:0070189)3.62980006
22microtubule depolymerization (GO:0007019)3.54822086
23response to pheromone (GO:0019236)3.49001216
24keratinocyte development (GO:0003334)3.48098896
25regulation of timing of cell differentiation (GO:0048505)3.43213617
26negative regulation of mast cell activation (GO:0033004)3.42563003
27regulation of nuclear cell cycle DNA replication (GO:0033262)3.42414523
28mitotic metaphase plate congression (GO:0007080)3.39173785
29notochord development (GO:0030903)3.35064173
30tryptophan metabolic process (GO:0006568)3.32987448
31reflex (GO:0060004)3.31413174
32rRNA modification (GO:0000154)3.29473862
33detection of light stimulus involved in visual perception (GO:0050908)3.28443318
34detection of light stimulus involved in sensory perception (GO:0050962)3.28443318
35cellular ketone body metabolic process (GO:0046950)3.22381228
36regulation of development, heterochronic (GO:0040034)3.19914902
37positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.17026310
38female gonad development (GO:0008585)3.15702807
39negative regulation of keratinocyte proliferation (GO:0010839)3.11833176
40sulfation (GO:0051923)3.10428468
41ribosome assembly (GO:0042255)3.09595448
42regulation of telomere maintenance via telomerase (GO:0032210)3.08358432
43protein K48-linked deubiquitination (GO:0071108)3.04385545
44monoubiquitinated protein deubiquitination (GO:0035520)3.03754020
45desmosome organization (GO:0002934)3.02088410
46piRNA metabolic process (GO:0034587)2.99784222
47DNA methylation involved in gamete generation (GO:0043046)2.91750145
48rRNA catabolic process (GO:0016075)2.90459722
49cornea development in camera-type eye (GO:0061303)2.89561940
50response to X-ray (GO:0010165)2.89006921
51lung-associated mesenchyme development (GO:0060484)2.88852702
52long-chain fatty acid biosynthetic process (GO:0042759)2.88702456
53axoneme assembly (GO:0035082)2.88581330
54ketone body metabolic process (GO:1902224)2.88262821
55cAMP catabolic process (GO:0006198)2.88186752
56cellular response to ethanol (GO:0071361)2.87994759
57regulation of germinal center formation (GO:0002634)2.87816009
58regulation of pigment cell differentiation (GO:0050932)2.87808925
59paraxial mesoderm development (GO:0048339)2.86874666
60gamma-aminobutyric acid transport (GO:0015812)2.85286148
61metaphase plate congression (GO:0051310)2.84951080
62snRNA transcription (GO:0009301)2.84152984
63rRNA methylation (GO:0031167)2.82601247
64termination of RNA polymerase I transcription (GO:0006363)2.82125872
65cilium morphogenesis (GO:0060271)2.81606910
66transcription from RNA polymerase I promoter (GO:0006360)2.80103836
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79673903
68protein targeting to Golgi (GO:0000042)2.79354686
69histone H3-K4 trimethylation (GO:0080182)2.78109843
70transcription initiation from RNA polymerase I promoter (GO:0006361)2.77594310
71positive regulation of developmental pigmentation (GO:0048087)2.77129703
72inner cell mass cell proliferation (GO:0001833)2.76593758
73nephron epithelium morphogenesis (GO:0072088)2.76539935
74nephron tubule morphogenesis (GO:0072078)2.76539935
75iron ion import (GO:0097286)2.75529057
76photoreceptor cell maintenance (GO:0045494)2.75416189
77phosphatidylinositol acyl-chain remodeling (GO:0036149)2.74594535
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.73749100
79activated T cell proliferation (GO:0050798)2.73027051
80establishment of skin barrier (GO:0061436)2.72873984
81positive regulation of fatty acid oxidation (GO:0046321)2.72214923
82cilium movement (GO:0003341)2.71048960
83sphingosine metabolic process (GO:0006670)2.70804923
84NAD biosynthetic process (GO:0009435)2.69270076
85drug catabolic process (GO:0042737)2.68672015
86indole-containing compound metabolic process (GO:0042430)2.68430916
87blastocyst development (GO:0001824)2.67941529
88cardiovascular system development (GO:0072358)2.67158260
89epithelial cilium movement (GO:0003351)2.66844858
90embryonic epithelial tube formation (GO:0001838)2.66140153
91nucleotide-sugar biosynthetic process (GO:0009226)2.65600720
92negative regulation of execution phase of apoptosis (GO:1900118)2.65304355
93regulation of keratinocyte proliferation (GO:0010837)2.64982841
94thyroid hormone metabolic process (GO:0042403)2.63322947
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62561057
96protein K63-linked deubiquitination (GO:0070536)2.59066729
97kidney morphogenesis (GO:0060993)2.59005525
98cyclic nucleotide catabolic process (GO:0009214)2.58188484
99retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57408577
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.57258898
101regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.55730025
102oxidative demethylation (GO:0070989)2.55593243
103cilium organization (GO:0044782)2.54532468
104macroautophagy (GO:0016236)2.54407554
105regulation of water loss via skin (GO:0033561)2.54120011
106face development (GO:0060324)2.53442338
107lateral sprouting from an epithelium (GO:0060601)2.53272694
108histone H4-K12 acetylation (GO:0043983)2.52894771
109regulation of establishment of cell polarity (GO:2000114)2.52640384
110cellular biogenic amine catabolic process (GO:0042402)2.51844014
111amine catabolic process (GO:0009310)2.51844014
112diol metabolic process (GO:0034311)2.51588693
113negative regulation of systemic arterial blood pressure (GO:0003085)2.50108745
114regulation of translation in response to stress (GO:0043555)2.49637466
115cellular response to gamma radiation (GO:0071480)2.49560927
116parturition (GO:0007567)2.49256785
117behavioral response to ethanol (GO:0048149)2.48835828
118cilium assembly (GO:0042384)2.48701100
119regulation of establishment or maintenance of cell polarity (GO:0032878)2.48603920
120regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48431864
121regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.48084402
122benzene-containing compound metabolic process (GO:0042537)2.47801514
123protein localization to Golgi apparatus (GO:0034067)2.47788183
124columnar/cuboidal epithelial cell development (GO:0002066)2.47383215
125positive regulation of CREB transcription factor activity (GO:0032793)2.47315858
126positive regulation of fatty acid beta-oxidation (GO:0032000)2.47158661
127nuclear pore organization (GO:0006999)2.46682532
128histone monoubiquitination (GO:0010390)2.46513002
129regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.46399995
130retinal cone cell development (GO:0046549)2.45901912
131neuronal action potential (GO:0019228)2.45748880
132histone H3-K9 methylation (GO:0051567)2.44415348
133vitamin transmembrane transport (GO:0035461)2.44271126
134microtubule polymerization or depolymerization (GO:0031109)2.44054754
135regulation of meiosis I (GO:0060631)2.43219175
136negative regulation of sodium ion transport (GO:0010766)2.43024170
137lipid translocation (GO:0034204)2.42656933
138phospholipid translocation (GO:0045332)2.42656933
139branching involved in labyrinthine layer morphogenesis (GO:0060670)2.42595912
140regulation of memory T cell differentiation (GO:0043380)2.42583725
141regulation of action potential (GO:0098900)2.42348870
142nucleobase biosynthetic process (GO:0046112)2.41478691
143tRNA methylation (GO:0030488)2.41411558
144purine nucleobase biosynthetic process (GO:0009113)2.40987968
145epithelial tube formation (GO:0072175)2.40890803
146cellular response to ATP (GO:0071318)2.40755082
147startle response (GO:0001964)2.40459001
148polyol transport (GO:0015791)2.39491540
149preassembly of GPI anchor in ER membrane (GO:0016254)2.39082612
150flavonoid metabolic process (GO:0009812)2.38921030
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.38283914
152regulation of spindle checkpoint (GO:0090231)2.38061804
153regulation of hippo signaling (GO:0035330)2.37837008
154phosphatidylserine acyl-chain remodeling (GO:0036150)2.37574076
155signal peptide processing (GO:0006465)2.37336797
156primary amino compound metabolic process (GO:1901160)2.37180647
157exogenous drug catabolic process (GO:0042738)2.36273270
158serotonin metabolic process (GO:0042428)2.34805633
159DNA replication checkpoint (GO:0000076)2.34661322
160fucosylation (GO:0036065)2.34505308
161sphingoid metabolic process (GO:0046519)2.34266536
162reciprocal DNA recombination (GO:0035825)2.33982541
163reciprocal meiotic recombination (GO:0007131)2.33982541
164otic vesicle formation (GO:0030916)2.33243407
165negative regulation of myoblast differentiation (GO:0045662)2.33006631
1663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.32193491
167DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.31880611
168mammary gland development (GO:0030879)2.30620352
169inner ear receptor stereocilium organization (GO:0060122)2.30533438
170ribosome biogenesis (GO:0042254)2.30116424
171DNA damage response, signal transduction resulting in transcription (GO:0042772)2.29799511
172regulation of spindle organization (GO:0090224)2.29774736
173nuclear pore complex assembly (GO:0051292)2.28492273
174positive regulation of mRNA processing (GO:0050685)2.28252357
175negative regulation of androgen receptor signaling pathway (GO:0060766)2.28172552
176outflow tract septum morphogenesis (GO:0003148)2.27638137
177regulation of somitogenesis (GO:0014807)2.27527190
178superoxide anion generation (GO:0042554)2.27132232
179replicative senescence (GO:0090399)2.25929717
180negative regulation of translation, ncRNA-mediated (GO:0040033)2.25501343
181regulation of translation, ncRNA-mediated (GO:0045974)2.25501343
182negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.25501343
183central nervous system myelination (GO:0022010)2.25158753
184axon ensheathment in central nervous system (GO:0032291)2.25158753
185limb bud formation (GO:0060174)2.23236770
186spindle assembly involved in mitosis (GO:0090307)2.23092534
187pore complex assembly (GO:0046931)2.22563893
188cellular response to ionizing radiation (GO:0071479)2.22427120
189regulation of mesoderm development (GO:2000380)2.22267730
190positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.21372199
191regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.21372199
192auditory receptor cell stereocilium organization (GO:0060088)2.20980896
193response to gamma radiation (GO:0010332)2.20667989
194sulfate transport (GO:0008272)2.20660721
195regulation of histone H3-K27 methylation (GO:0061085)2.20318504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.89117714
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.94347514
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.89913346
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.89913346
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.89913346
6ZNF274_21170338_ChIP-Seq_K562_Hela3.21828609
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14892738
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.96785702
9GBX2_23144817_ChIP-Seq_PC3_Human2.88231976
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.87198443
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69152844
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.61879001
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.57975504
14IGF1R_20145208_ChIP-Seq_DFB_Human2.42078640
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35611592
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30602670
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.26629714
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26485868
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13009430
20TAF15_26573619_Chip-Seq_HEK293_Human2.11041032
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08796995
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06917714
23PIAS1_25552417_ChIP-Seq_VCAP_Human2.06277470
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05800075
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.04196210
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03737395
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03131256
28SUZ12_27294783_Chip-Seq_NPCs_Mouse2.02630258
29ER_23166858_ChIP-Seq_MCF-7_Human2.01588363
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.98616807
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97360888
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.96701206
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.85799187
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.84445821
35STAT3_23295773_ChIP-Seq_U87_Human1.83884734
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80831640
37AR_21572438_ChIP-Seq_LNCaP_Human1.80203703
38P300_19829295_ChIP-Seq_ESCs_Human1.80028254
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78036166
40* EWS_26573619_Chip-Seq_HEK293_Human1.76907173
41FUS_26573619_Chip-Seq_HEK293_Human1.76134121
42AR_21909140_ChIP-Seq_LNCAP_Human1.74041394
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.71500743
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70482247
45TP53_16413492_ChIP-PET_HCT116_Human1.70326499
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69826373
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69012844
48NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66329802
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.66178048
50* TCF4_23295773_ChIP-Seq_U87_Human1.64471700
51SMAD4_21799915_ChIP-Seq_A2780_Human1.63618751
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62230248
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61995675
54* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.60671740
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60422655
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59760207
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.59527954
58BCAT_22108803_ChIP-Seq_LS180_Human1.59292383
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56892323
60AR_25329375_ChIP-Seq_VCAP_Human1.56763187
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55951471
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54795326
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54650599
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51434562
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51434562
66TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.50270542
67* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49959895
68EZH2_22144423_ChIP-Seq_EOC_Human1.49834407
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.48427624
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48054142
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46974085
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43554407
73AHR_22903824_ChIP-Seq_MCF-7_Human1.42501914
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.40721618
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40218793
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39892276
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.38882112
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38018176
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37964969
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37193702
81CBP_20019798_ChIP-Seq_JUKART_Human1.37193702
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.37074905
83MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36902695
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36422357
85NANOG_18692474_ChIP-Seq_MESCs_Mouse1.35550025
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33828562
87TCF4_22108803_ChIP-Seq_LS180_Human1.33558651
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.31927311
89* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.31314475
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30930881
91RUNX2_22187159_ChIP-Seq_PCA_Human1.30220613
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29488275
93IRF1_19129219_ChIP-ChIP_H3396_Human1.29352434
94MYC_18555785_ChIP-Seq_MESCs_Mouse1.29152650
95TRIM28_21343339_ChIP-Seq_HEK293_Human1.28869173
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.28369339
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28283013
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25901250
99* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25704206
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25595717
101DROSHA_22980978_ChIP-Seq_HELA_Human1.24869734
102EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24021408
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.23587987
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23582580
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.21912931
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21172181
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20839237
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19118204
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19028326
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18121014
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17766083
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.17616138
113FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15990743
114KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15611672
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.15418946
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15198871
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.13997321
118VDR_22108803_ChIP-Seq_LS180_Human1.13879033
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.13754000
120IRF8_22096565_ChIP-ChIP_GC-B_Human1.13627482
121CDX2_22108803_ChIP-Seq_LS180_Human1.13352503
122REST_21632747_ChIP-Seq_MESCs_Mouse1.12893010
123SMAD_19615063_ChIP-ChIP_OVARY_Human1.12673463
124ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12473258
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12396790
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11886792
127STAT3_18555785_Chip-Seq_ESCs_Mouse1.11854337
128EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10778184
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10124489
130EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09388723
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09109886
132RXR_22108803_ChIP-Seq_LS180_Human1.09016678
133ZFX_18555785_Chip-Seq_ESCs_Mouse1.08997644
134RNF2_27304074_Chip-Seq_NSC_Mouse1.08955430
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08536719
136STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08401875
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07314119
138CBX2_27304074_Chip-Seq_ESCs_Mouse1.07252462
139FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07017494
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06571297
141E2F1_18555785_Chip-Seq_ESCs_Mouse1.06498192
142SOX2_19829295_ChIP-Seq_ESCs_Human1.06311059
143NANOG_19829295_ChIP-Seq_ESCs_Human1.06311059
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.06218247
145FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06218247
146NANOG_18692474_ChIP-Seq_MEFs_Mouse1.05897290
147* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.05864873
148ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04759760
149ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04497287
150KLF4_18555785_Chip-Seq_ESCs_Mouse1.04267483
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03977252
152P300_18555785_Chip-Seq_ESCs_Mouse1.03964143
153* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03890853
154TP53_22573176_ChIP-Seq_HFKS_Human1.03778645
155MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03643603
156SOX2_21211035_ChIP-Seq_LN229_Gbm1.03425949
157ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03156081
158GATA3_21878914_ChIP-Seq_MCF-7_Human1.02497834
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02264314
160HOXB7_26014856_ChIP-Seq_BT474_Human1.02176028
161CRX_20693478_ChIP-Seq_RETINA_Mouse1.00637819
162CMYC_18555785_Chip-Seq_ESCs_Mouse0.98794980
163KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98120859
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97369995
165NANOG_16153702_ChIP-ChIP_HESCs_Human0.96223425
166OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96010438
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95557206
168* YY1_21170310_ChIP-Seq_MESCs_Mouse0.95063436
169SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94911133
170NMYC_18555785_Chip-Seq_ESCs_Mouse0.94652577
171SMAD1_18555785_Chip-Seq_ESCs_Mouse0.94109094
172RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92030208
173P53_22387025_ChIP-Seq_ESCs_Mouse0.91263694
174SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90781757
175ESR2_21235772_ChIP-Seq_MCF-7_Human0.89340618
176CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88846283
177SOX2_16153702_ChIP-ChIP_HESCs_Human0.88814115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.46495085
2MP0003136_yellow_coat_color4.30365455
3MP0004043_abnormal_pH_regulation3.37624568
4MP0003941_abnormal_skin_development3.37134117
5MP0003195_calcinosis2.93914442
6MP0005171_absent_coat_pigmentation2.87055322
7MP0000383_abnormal_hair_follicle2.63377315
8MP0003693_abnormal_embryo_hatching2.55117796
9MP0001501_abnormal_sleep_pattern2.44613253
10MP0005551_abnormal_eye_electrophysiolog2.44141257
11MP0003111_abnormal_nucleus_morphology2.38977690
12MP0008789_abnormal_olfactory_epithelium2.37792201
13MP0008057_abnormal_DNA_replication2.36024261
14MP0000462_abnormal_digestive_system2.32848511
15MP0002876_abnormal_thyroid_physiology2.28048374
16MP0003646_muscle_fatigue2.27567573
17MP0005377_hearing/vestibular/ear_phenot2.23512534
18MP0003878_abnormal_ear_physiology2.23512534
19MP0008961_abnormal_basal_metabolism2.10581617
20MP0000613_abnormal_salivary_gland2.09445993
21MP0003718_maternal_effect2.00599089
22MP0005394_taste/olfaction_phenotype1.98308733
23MP0005499_abnormal_olfactory_system1.98308733
24MP0010094_abnormal_chromosome_stability1.98126314
25MP0001346_abnormal_lacrimal_gland1.97696110
26MP0005174_abnormal_tail_pigmentation1.94490404
27MP0008875_abnormal_xenobiotic_pharmacok1.94026051
28MP0000762_abnormal_tongue_morphology1.88216861
29MP0000566_synostosis1.83123656
30MP0009046_muscle_twitch1.82578770
31MP0002928_abnormal_bile_duct1.81349266
32MP0001968_abnormal_touch/_nociception1.80819891
33MP0003787_abnormal_imprinting1.80256028
34MP0002277_abnormal_respiratory_mucosa1.80249506
35MP0010678_abnormal_skin_adnexa1.79550113
36MP0001188_hyperpigmentation1.79137882
37MP0008058_abnormal_DNA_repair1.78919320
38MP0004957_abnormal_blastocyst_morpholog1.75724612
39MP0008260_abnormal_autophagy1.74685382
40MP0008932_abnormal_embryonic_tissue1.73713197
41MP0003252_abnormal_bile_duct1.71276601
42MP0003937_abnormal_limbs/digits/tail_de1.67713557
43MP0003786_premature_aging1.67614764
44MP0008877_abnormal_DNA_methylation1.67217792
45MP0004142_abnormal_muscle_tone1.65979173
46MP0010030_abnormal_orbit_morphology1.64682247
47MP0002653_abnormal_ependyma_morphology1.63583867
48MP0001986_abnormal_taste_sensitivity1.63136348
49MP0004381_abnormal_hair_follicle1.61662086
50MP0002233_abnormal_nose_morphology1.59517905
51MP0005646_abnormal_pituitary_gland1.55276854
52MP0009745_abnormal_behavioral_response1.55236925
53MP0002138_abnormal_hepatobiliary_system1.54565843
54MP0006292_abnormal_olfactory_placode1.54258955
55MP0005379_endocrine/exocrine_gland_phen1.53822371
56MP0004130_abnormal_muscle_cell1.53527355
57MP0002009_preneoplasia1.49805011
58MP0002837_dystrophic_cardiac_calcinosis1.49321304
59MP0003183_abnormal_peptide_metabolism1.49319153
60MP0005451_abnormal_body_composition1.48554189
61MP0003045_fibrosis1.47840198
62MP0005645_abnormal_hypothalamus_physiol1.47644456
63MP0002098_abnormal_vibrissa_morphology1.47160751
64MP0001873_stomach_inflammation1.46675286
65MP0000631_abnormal_neuroendocrine_gland1.46552206
66MP0004924_abnormal_behavior1.45977037
67MP0005386_behavior/neurological_phenoty1.45977037
68MP0005389_reproductive_system_phenotype1.45429088
69MP0008872_abnormal_physiological_respon1.44619209
70MP0003077_abnormal_cell_cycle1.43744394
71MP0001485_abnormal_pinna_reflex1.43614558
72MP0002638_abnormal_pupillary_reflex1.43378207
73MP0005503_abnormal_tendon_morphology1.42275043
74MP0001919_abnormal_reproductive_system1.42240449
75MP0002102_abnormal_ear_morphology1.41189985
76MP0005310_abnormal_salivary_gland1.38891657
77MP0005085_abnormal_gallbladder_physiolo1.38547666
78MP0009250_abnormal_appendicular_skeleto1.38372243
79MP0003755_abnormal_palate_morphology1.38131099
80MP0005409_darkened_coat_color1.35285864
81MP0003938_abnormal_ear_development1.34671966
82MP0002938_white_spotting1.32548478
83MP0003890_abnormal_embryonic-extraembry1.32291874
84MP0002249_abnormal_larynx_morphology1.31860188
85MP0004133_heterotaxia1.28538824
86MP0001293_anophthalmia1.27373012
87MP0004147_increased_porphyrin_level1.27026500
88MP0000432_abnormal_head_morphology1.26976136
89MP0010386_abnormal_urinary_bladder1.26829618
90MP0005253_abnormal_eye_physiology1.26508901
91MP0005257_abnormal_intraocular_pressure1.20598557
92MP0005508_abnormal_skeleton_morphology1.20282701
93MP0000230_abnormal_systemic_arterial1.19534900
94MP0000647_abnormal_sebaceous_gland1.13908008
95MP0002736_abnormal_nociception_after1.13577358
96MP0008438_abnormal_cutaneous_collagen1.12378744
97MP0003315_abnormal_perineum_morphology1.11878074
98MP0002272_abnormal_nervous_system1.11732118
99MP0004145_abnormal_muscle_electrophysio1.10312313
100MP0001984_abnormal_olfaction1.08337138
101MP0000579_abnormal_nail_morphology1.06430128
102MP0002210_abnormal_sex_determination1.06218869
103MP0001486_abnormal_startle_reflex1.05793636
104MP0005275_abnormal_skin_tensile1.05323985
105MP0002111_abnormal_tail_morphology1.04575675
106MP0004885_abnormal_endolymph1.03409339
107MP0002735_abnormal_chemical_nociception1.03236261
108MP0002909_abnormal_adrenal_gland1.03156724
109MP0005187_abnormal_penis_morphology1.02523317
110MP0001542_abnormal_bone_strength1.02371729
111MP0002168_other_aberrant_phenotype1.01505956
112MP0000015_abnormal_ear_pigmentation1.01411839
113MP0005623_abnormal_meninges_morphology1.00945400
114MP0001765_abnormal_ion_homeostasis1.00322046
115MP0002060_abnormal_skin_morphology1.00216922
116MP0004742_abnormal_vestibular_system0.98607203
117MP0002572_abnormal_emotion/affect_behav0.98331708
118MP0002116_abnormal_craniofacial_bone0.97439622
119MP0002064_seizures0.97429150
120MP0000538_abnormal_urinary_bladder0.97230961
121MP0000350_abnormal_cell_proliferation0.97123180
122MP0008775_abnormal_heart_ventricle0.97107461
123MP0002132_abnormal_respiratory_system0.96952984
124MP0002557_abnormal_social/conspecific_i0.96916183
125MP0001286_abnormal_eye_development0.96347837
126MP0005367_renal/urinary_system_phenotyp0.96278599
127MP0000516_abnormal_urinary_system0.96278599
128MP0000427_abnormal_hair_cycle0.95231035
129MP0000049_abnormal_middle_ear0.94227784
130MP0004484_altered_response_of0.93589649
131MP0000467_abnormal_esophagus_morphology0.93306743
132MP0003936_abnormal_reproductive_system0.92567338
133MP0002095_abnormal_skin_pigmentation0.92566685
134MP0008995_early_reproductive_senescence0.91754509
135MP0002733_abnormal_thermal_nociception0.91726798
136MP0002160_abnormal_reproductive_system0.91710938
137MP0005167_abnormal_blood-brain_barrier0.91645072
138MP0002067_abnormal_sensory_capabilities0.91206926
139MP0002085_abnormal_embryonic_tissue0.90978376
140MP0001970_abnormal_pain_threshold0.90577702
141MP0001502_abnormal_circadian_rhythm0.90293430
142MP0001145_abnormal_male_reproductive0.89445223
143MP0000026_abnormal_inner_ear0.88346697
144MP0003943_abnormal_hepatobiliary_system0.87915765
145MP0004215_abnormal_myocardial_fiber0.87900761
146MP0010329_abnormal_lipoprotein_level0.87896506
147MP0001672_abnormal_embryogenesis/_devel0.86578673
148MP0005380_embryogenesis_phenotype0.86578673
149MP0000377_abnormal_hair_follicle0.84626094
150MP0001664_abnormal_digestion0.84244337
151MP0002693_abnormal_pancreas_physiology0.83827305
152MP0003935_abnormal_craniofacial_develop0.83763708
153MP0001756_abnormal_urination0.83504422
154MP0003453_abnormal_keratinocyte_physiol0.83332129
155MP0001216_abnormal_epidermal_layer0.82714056
156MP0003950_abnormal_plasma_membrane0.82688039
157MP0001324_abnormal_eye_pigmentation0.82659533
158MP0000428_abnormal_craniofacial_morphol0.82343811
159MP0006276_abnormal_autonomic_nervous0.82211219
160MP0002796_impaired_skin_barrier0.81487271
161MP0003011_delayed_dark_adaptation0.81410849
162MP0008007_abnormal_cellular_replicative0.81204878
163MP0003137_abnormal_impulse_conducting0.79847785
164MP0000371_diluted_coat_color0.79315275
165MP0001963_abnormal_hearing_physiology0.78972735
166MP0002114_abnormal_axial_skeleton0.78278576
167MP0006054_spinal_hemorrhage0.77278631
168MP0005448_abnormal_energy_balance0.76870623
169MP0000653_abnormal_sex_gland0.76748267
170MP0000470_abnormal_stomach_morphology0.76668022
171MP0000372_irregular_coat_pigmentation0.76355681
172MP0002229_neurodegeneration0.76221372
173MP0002163_abnormal_gland_morphology0.76164363
174MP0002177_abnormal_outer_ear0.75973718
175MP0005501_abnormal_skin_physiology0.75868139
176MP0002084_abnormal_developmental_patter0.75835216
177MP0000627_abnormal_mammary_gland0.74418072
178MP0006072_abnormal_retinal_apoptosis0.71653360

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.13010686
2Pancreatic cysts (HP:0001737)5.02429330
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.78604313
4Upper limb muscle weakness (HP:0003484)4.44069577
5Chromsome breakage (HP:0040012)4.31698444
6Pancreatic fibrosis (HP:0100732)4.26327631
7True hermaphroditism (HP:0010459)4.09809587
8Protruding tongue (HP:0010808)3.91489295
9Genetic anticipation (HP:0003743)3.87738096
10Congenital stationary night blindness (HP:0007642)3.83394538
11Abnormality of the renal cortex (HP:0011035)3.82121923
12Molar tooth sign on MRI (HP:0002419)3.74877277
13Abnormality of midbrain morphology (HP:0002418)3.74877277
14Gaze-evoked nystagmus (HP:0000640)3.55022914
15Nephronophthisis (HP:0000090)3.49971359
16Decreased circulating renin level (HP:0003351)3.48572496
17Abnormality of the renal medulla (HP:0100957)3.34085045
18Progressive cerebellar ataxia (HP:0002073)3.23881330
19Tubular atrophy (HP:0000092)3.22054763
20Cystic liver disease (HP:0006706)3.21689024
21Fair hair (HP:0002286)3.20371088
22Adrenal hypoplasia (HP:0000835)3.16265426
23Clumsiness (HP:0002312)3.12804499
24Parakeratosis (HP:0001036)2.98151054
25Chronic hepatic failure (HP:0100626)2.96479529
26Prostate neoplasm (HP:0100787)2.94885092
27Broad-based gait (HP:0002136)2.87091367
28Medial flaring of the eyebrow (HP:0010747)2.86520654
29Abnormal drinking behavior (HP:0030082)2.85667891
30Polydipsia (HP:0001959)2.85667891
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.71017949
32Absent/shortened dynein arms (HP:0200106)2.71017949
33Cerebral hypomyelination (HP:0006808)2.68669529
34Generalized hypopigmentation of hair (HP:0011358)2.68466108
35Attenuation of retinal blood vessels (HP:0007843)2.67394850
36Furrowed tongue (HP:0000221)2.66048917
37White forelock (HP:0002211)2.58910639
38Stomach cancer (HP:0012126)2.58648173
39Absent speech (HP:0001344)2.58507668
40Absent radius (HP:0003974)2.58362504
41Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58302960
42Impulsivity (HP:0100710)2.56105233
43Widely spaced teeth (HP:0000687)2.55917529
44Abnormality of the labia minora (HP:0012880)2.53432991
45Abnormal biliary tract physiology (HP:0012439)2.50939982
46Bile duct proliferation (HP:0001408)2.50939982
47Congenital hepatic fibrosis (HP:0002612)2.48033132
48Nephroblastoma (Wilms tumor) (HP:0002667)2.47906065
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47357859
50Abnormality of alanine metabolism (HP:0010916)2.47357859
51Hyperalaninemia (HP:0003348)2.47357859
52Renal cortical cysts (HP:0000803)2.45438040
53Large for gestational age (HP:0001520)2.44459222
54Meckel diverticulum (HP:0002245)2.42350550
55Duplicated collecting system (HP:0000081)2.41474124
56Submucous cleft hard palate (HP:0000176)2.41334922
57Abnormality of the preputium (HP:0100587)2.40528022
58Absent forearm bone (HP:0003953)2.39748953
59Aplasia involving forearm bones (HP:0009822)2.39748953
60Gait imbalance (HP:0002141)2.38969324
61Ureteral duplication (HP:0000073)2.37601709
62Type II lissencephaly (HP:0007260)2.37513828
63Patchy hypopigmentation of hair (HP:0011365)2.35771052
64Progressive inability to walk (HP:0002505)2.35000219
65Septo-optic dysplasia (HP:0100842)2.34140334
66Aplasia cutis congenita (HP:0001057)2.33534987
67Congenital primary aphakia (HP:0007707)2.33519237
68Abnormality of cochlea (HP:0000375)2.33311061
69Stillbirth (HP:0003826)2.32841227
70Abnormality of the proximal phalanges of the hand (HP:0009834)2.32760135
71Embryonal renal neoplasm (HP:0011794)2.32706157
72Morphological abnormality of the inner ear (HP:0011390)2.32162615
73Abnormality of the renal collecting system (HP:0004742)2.30249393
74Abnormality of the ileum (HP:0001549)2.28200287
75Inability to walk (HP:0002540)2.27099177
76Premature rupture of membranes (HP:0001788)2.26839115
77Rectal fistula (HP:0100590)2.25949035
78Rectovaginal fistula (HP:0000143)2.25949035
79Increased corneal curvature (HP:0100692)2.20081746
80Keratoconus (HP:0000563)2.20081746
81Febrile seizures (HP:0002373)2.19942783
82Nephrogenic diabetes insipidus (HP:0009806)2.19574903
83Breast hypoplasia (HP:0003187)2.18306515
84Aplasia/Hypoplasia of the tongue (HP:0010295)2.18286394
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.17428437
86Chorioretinal atrophy (HP:0000533)2.14768784
87Poor coordination (HP:0002370)2.14526103
88Abolished electroretinogram (ERG) (HP:0000550)2.13459585
89Osteomalacia (HP:0002749)2.10978659
90Polyuria (HP:0000103)2.09491243
91Birth length less than 3rd percentile (HP:0003561)2.09452393
92Lip pit (HP:0100267)2.09408225
93Sclerocornea (HP:0000647)2.09340100
94Postaxial foot polydactyly (HP:0001830)2.08408056
95Congenital sensorineural hearing impairment (HP:0008527)2.06876257
96Anencephaly (HP:0002323)2.06286460
97Irregular epiphyses (HP:0010582)2.06216125
98Abnormal respiratory motile cilium morphology (HP:0005938)2.05255141
99Abnormal respiratory epithelium morphology (HP:0012253)2.05255141
100Drooling (HP:0002307)2.04455005
101Aplasia/hypoplasia of the humerus (HP:0006507)2.04029025
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.03785849
103Abnormality of renin-angiotensin system (HP:0000847)2.03212495
104Male pseudohermaphroditism (HP:0000037)2.02774006
105Hypoplastic labia majora (HP:0000059)2.02748840
106Genital tract atresia (HP:0001827)2.00549303
107Cerebellar dysplasia (HP:0007033)1.98440829
108Vaginal atresia (HP:0000148)1.98111846
109Anal stenosis (HP:0002025)1.96957061
110Lissencephaly (HP:0001339)1.96843260
111Short clavicles (HP:0000894)1.96762182
112Small epiphyses (HP:0010585)1.95363005
113Intestinal fistula (HP:0100819)1.95237065
114Carpal bone hypoplasia (HP:0001498)1.94836676
115Abnormality of chromosome stability (HP:0003220)1.94791584
116Preauricular pit (HP:0004467)1.94751679
117Periauricular skin pits (HP:0100277)1.94751679
118Decreased central vision (HP:0007663)1.91549249
119Abnormal rod and cone electroretinograms (HP:0008323)1.91235437
120Duplication of thumb phalanx (HP:0009942)1.90799390
121Abnormality of the carotid arteries (HP:0005344)1.90525201
122Short thumb (HP:0009778)1.89094545
123Macroglossia (HP:0000158)1.89072962
124Hypoplastic ischia (HP:0003175)1.88842041
125Abnormal ciliary motility (HP:0012262)1.88453351
126Abnormality of the labia majora (HP:0012881)1.87868955
127Short humerus (HP:0005792)1.87753881
128Excessive salivation (HP:0003781)1.87381578
129Flat capital femoral epiphysis (HP:0003370)1.86821825
130Abnormality of the pons (HP:0007361)1.84683790
131Amelogenesis imperfecta (HP:0000705)1.83488082
132Bony spicule pigmentary retinopathy (HP:0007737)1.80212789
133Vaginal fistula (HP:0004320)1.78296143
134Nasolacrimal duct obstruction (HP:0000579)1.77598519
135Duodenal stenosis (HP:0100867)1.76662517
136Small intestinal stenosis (HP:0012848)1.76662517
137Aplasia/Hypoplasia of the patella (HP:0006498)1.76236519
138Metabolic alkalosis (HP:0200114)1.76028408
139Ectopic kidney (HP:0000086)1.75852708
140Patellar aplasia (HP:0006443)1.74633876
141Hyperkalemia (HP:0002153)1.74008635
142Aplasia/Hypoplasia of the spleen (HP:0010451)1.73875982
143Tachypnea (HP:0002789)1.72332675
144Aplasia/hypoplasia of the uterus (HP:0008684)1.72259289
145Epiphyseal dysplasia (HP:0002656)1.72136611
146Rough bone trabeculation (HP:0100670)1.71112656
147Abnormal number of incisors (HP:0011064)1.70138518
148Short foot (HP:0001773)1.69451141
149Thyroiditis (HP:0100646)1.69164264
150Supernumerary spleens (HP:0009799)1.68806346
151Hypoplasia of the pons (HP:0012110)1.68635965
152Sensory axonal neuropathy (HP:0003390)1.68082818
153Hemiparesis (HP:0001269)1.67686519
154Increased neuronal autofluorescent lipopigment (HP:0002074)1.66868464
155Enlarged kidneys (HP:0000105)1.66501723
156Hypoplastic iliac wings (HP:0002866)1.66204738
157Aplasia/Hypoplasia of the clavicles (HP:0006710)1.66195366
158Abnormal auditory evoked potentials (HP:0006958)1.65583743
159Segmental peripheral demyelination/remyelination (HP:0003481)1.65177838
160Abnormal urine output (HP:0012590)1.64378791
161Septate vagina (HP:0001153)1.64135647
162Bulbous nose (HP:0000414)1.64045305
163Aplasia/Hypoplasia of the ulna (HP:0006495)1.63773241
164Abnormality of the nasal septum (HP:0000419)1.63424557
165Supernumerary bones of the axial skeleton (HP:0009144)1.62938993
166Aplasia/Hypoplasia of the earlobes (HP:0009906)1.62275076
167Follicular hyperkeratosis (HP:0007502)1.61636262
168Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.61156100
169Aplasia/Hypoplasia of the fovea (HP:0008060)1.60991063
170Hypoplasia of the fovea (HP:0007750)1.60991063
171Absent septum pellucidum (HP:0001331)1.60707497
172Rib fusion (HP:0000902)1.60565384
173Abnormality of the septum pellucidum (HP:0007375)1.60102761
174Cupped ear (HP:0000378)1.58165975
175Absent eyebrow (HP:0002223)1.58127193
176Microvesicular hepatic steatosis (HP:0001414)1.57530381
177Genu varum (HP:0002970)1.57454674
178Concave nail (HP:0001598)1.57439882
179Abnormality of the ischium (HP:0003174)1.56507490
180Abnormality of the distal phalanges of the toes (HP:0010182)1.56213621
181Aplasia of the musculature (HP:0100854)1.55648822
182Conical tooth (HP:0000698)1.54805974
183Abnormal trabecular bone morphology (HP:0100671)1.54226834
184Abnormality of the lacrimal duct (HP:0011481)1.53354555
185Abnormality of the nasolacrimal system (HP:0000614)1.53148560
186Triphalangeal thumb (HP:0001199)1.52337813
187Renal agenesis (HP:0000104)1.51728506
188Sparse eyelashes (HP:0000653)1.51620351
189Breast aplasia (HP:0100783)1.51420785
190Alopecia of scalp (HP:0002293)1.51013635
191Abnormality of the axillary hair (HP:0100134)1.50979809
192Abnormality of secondary sexual hair (HP:0009888)1.50979809
193Esophageal atresia (HP:0002032)1.50556732

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.51169971
2GRK13.31381240
3STK38L3.04504605
4EPHA22.84465313
5ADRBK22.71294183
6LATS12.62831722
7STK162.29271668
8ZAK2.28283549
9MKNK22.19535802
10STK392.17508296
11TAOK32.13546241
12BUB12.11127276
13TTK2.10720443
14CASK2.05489395
15SRPK12.03928497
16WEE11.95583675
17PBK1.93338137
18PLK41.86371350
19STK31.74421477
20MAPK131.74239937
21CAMKK21.70942080
22CDK121.60372375
23EIF2AK21.58224156
24CAMK1D1.55265082
25TXK1.51378846
26OXSR11.44829244
27CHEK21.44072079
28MAPK151.42574285
29STK241.41316811
30PLK31.37960416
31MKNK11.36220967
32CDK31.34913970
33NEK61.34377595
34MST1R1.33358573
35NUAK11.32341339
36MET1.30527897
37CDK71.26538195
38MAP3K41.25950278
39PLK11.24903929
40MST41.24824464
41TSSK61.24595827
42DDR21.23715364
43CAMK1G1.23295248
44PRKCI1.21280976
45PNCK1.21217157
46ADRBK11.18897319
47PAK31.18520139
48MAP4K21.16623644
49TNIK1.12062674
50PDK21.11430527
51PINK11.10525634
52EPHA31.10007165
53ACVR1B1.07807060
54IRAK31.06744584
55YES11.04798530
56VRK11.04439343
57NEK21.04307209
58DAPK21.03033554
59LMTK21.02787403
60PRKAA21.02362669
61WNK31.00316308
62PASK0.99683885
63NTRK30.98389890
64MAPKAPK30.96342136
65LATS20.96112226
66TRPM70.94971949
67MAP2K60.93208652
68SGK20.92016568
69MELK0.91521115
70PKN10.89878088
71STK40.89263449
72MAP3K70.88038108
73CHEK10.87498777
74PTK2B0.86760313
75CSNK1A1L0.86701013
76CDC70.86225190
77MAP3K30.84376835
78MAP2K20.81813794
79AURKB0.81449978
80TEC0.80342426
81RPS6KB20.79545921
82TGFBR10.79234987
83STK100.77497338
84DYRK30.77054818
85BRD40.76515139
86WNK10.75463457
87STK110.75408088
88ALK0.74288633
89TNK20.73493106
90BLK0.73487898
91CHUK0.71418936
92FGFR20.70889765
93PRKCE0.70513796
94FER0.70261177
95CSNK1G10.67366220
96ATM0.66409633
97NME20.66022354
98ERBB20.65578554
99WNK40.65337828
100CDK80.62871547
101AURKA0.59688103
102PIK3CG0.58990480
103DYRK20.58376809
104NME10.57871129
105ATR0.57855543
106IRAK10.57288026
107SIK20.57022842
108BCR0.56339664
109SGK4940.56101613
110SGK2230.56101613
111PRKAA10.55658519
112STK380.55605058
113MTOR0.55367580
114MAPKAPK50.55166807
115IRAK20.54611058
116CAMK10.54447305
117IKBKB0.53817364
118CSNK1D0.53775280
119PRKD20.53609425
120NLK0.53465710
121PRKCH0.52299851
122KIT0.51359871
123ITK0.50353592
124PRKCG0.49308563
125GSK3A0.49169759
126HIPK20.48559738
127PDK30.48460109
128PDK40.48460109
129BMPR1B0.47029941
130PAK10.46408142
131CAMK40.45647663
132JAK10.45548897
133CDK10.44120302
134SGK10.44119214
135CSNK1E0.44005701
136CSNK1G30.43656038
137PIK3CA0.43307624
138CDK20.42507029
139MARK10.41854991
140EIF2AK30.41844522
141PRKCQ0.40358226
142PDGFRB0.40181287
143TLK10.39928588
144FLT30.39713871
145EEF2K0.39134596
146FRK0.38998980
147INSRR0.38535235
148MAPK10.38517392
149CSNK1A10.38500829
150BRSK20.36941992
151MAPK70.36851554
152ERBB30.36083504
153RPS6KA60.35821961
154PRKCZ0.35350407
155PIM10.34983557
156SYK0.34551487
157MAP2K70.34250944
158CAMKK10.33029952
159BTK0.32560180
160PHKG10.31886497
161PHKG20.31886497
162MAP2K40.31524515
163MAPK110.31104924
164PRKACA0.28159918
165ABL10.27875576
166RPS6KA50.27813024

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27371028
2Fanconi anemia pathway_Homo sapiens_hsa034603.06557364
3Vitamin B6 metabolism_Homo sapiens_hsa007502.95467408
4RNA polymerase_Homo sapiens_hsa030202.90438497
5Basal transcription factors_Homo sapiens_hsa030222.61564527
6Nitrogen metabolism_Homo sapiens_hsa009102.60515681
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37259118
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.33851511
9Homologous recombination_Homo sapiens_hsa034402.20579679
10Non-homologous end-joining_Homo sapiens_hsa034502.14379370
11Butanoate metabolism_Homo sapiens_hsa006502.14156689
12Caffeine metabolism_Homo sapiens_hsa002322.14119003
13Sphingolipid metabolism_Homo sapiens_hsa006002.08974823
14ABC transporters_Homo sapiens_hsa020102.03397257
15Selenocompound metabolism_Homo sapiens_hsa004501.98080359
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93268917
17Cell cycle_Homo sapiens_hsa041101.87483947
18RNA transport_Homo sapiens_hsa030131.87145120
19Tryptophan metabolism_Homo sapiens_hsa003801.74554273
20Vitamin digestion and absorption_Homo sapiens_hsa049771.74484307
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.70450175
22Arachidonic acid metabolism_Homo sapiens_hsa005901.65563291
23p53 signaling pathway_Homo sapiens_hsa041151.64243870
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.61073459
25Nicotine addiction_Homo sapiens_hsa050331.59306607
26Pyrimidine metabolism_Homo sapiens_hsa002401.56935827
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.55656872
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51987055
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50952842
30Taste transduction_Homo sapiens_hsa047421.49515631
31Histidine metabolism_Homo sapiens_hsa003401.46179617
32Nucleotide excision repair_Homo sapiens_hsa034201.45561639
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44672686
34Mineral absorption_Homo sapiens_hsa049781.38716047
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37898527
36Mismatch repair_Homo sapiens_hsa034301.37766996
37Steroid biosynthesis_Homo sapiens_hsa001001.35811480
38Purine metabolism_Homo sapiens_hsa002301.35209745
39Olfactory transduction_Homo sapiens_hsa047401.32179675
40Folate biosynthesis_Homo sapiens_hsa007901.30561528
41Phototransduction_Homo sapiens_hsa047441.30465284
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27500675
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26814605
44Circadian rhythm_Homo sapiens_hsa047101.25385640
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24219096
46Glycerolipid metabolism_Homo sapiens_hsa005611.23521036
47Chemical carcinogenesis_Homo sapiens_hsa052041.21344955
48Protein digestion and absorption_Homo sapiens_hsa049741.19232229
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18437241
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18222389
51Morphine addiction_Homo sapiens_hsa050321.17767720
52One carbon pool by folate_Homo sapiens_hsa006701.13771507
53Linoleic acid metabolism_Homo sapiens_hsa005911.13490929
54Hedgehog signaling pathway_Homo sapiens_hsa043401.13109869
55Circadian entrainment_Homo sapiens_hsa047131.12946503
56mRNA surveillance pathway_Homo sapiens_hsa030151.12373784
57Spliceosome_Homo sapiens_hsa030401.12061125
58Glutamatergic synapse_Homo sapiens_hsa047241.11855031
59ECM-receptor interaction_Homo sapiens_hsa045121.10794139
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.10715928
61RNA degradation_Homo sapiens_hsa030181.07158688
62Salivary secretion_Homo sapiens_hsa049701.07076611
63MicroRNAs in cancer_Homo sapiens_hsa052061.05704280
64TGF-beta signaling pathway_Homo sapiens_hsa043501.05514039
65Serotonergic synapse_Homo sapiens_hsa047261.04284841
66Hippo signaling pathway_Homo sapiens_hsa043901.03504165
67Sulfur metabolism_Homo sapiens_hsa009201.01350346
68Basal cell carcinoma_Homo sapiens_hsa052171.00774439
69Melanoma_Homo sapiens_hsa052181.00017475
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.99690637
71Lysine degradation_Homo sapiens_hsa003100.99175776
72Insulin secretion_Homo sapiens_hsa049110.98403922
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.98383210
74Ether lipid metabolism_Homo sapiens_hsa005650.96597371
75Base excision repair_Homo sapiens_hsa034100.95608325
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95361910
77Calcium signaling pathway_Homo sapiens_hsa040200.94919501
78Propanoate metabolism_Homo sapiens_hsa006400.93239738
79Glutathione metabolism_Homo sapiens_hsa004800.92788301
80Tight junction_Homo sapiens_hsa045300.92303491
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91936715
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91261551
83Peroxisome_Homo sapiens_hsa041460.87984684
84DNA replication_Homo sapiens_hsa030300.87036187
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87017488
86Renin-angiotensin system_Homo sapiens_hsa046140.86452533
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83876478
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83852511
89Long-term depression_Homo sapiens_hsa047300.82533547
90Regulation of autophagy_Homo sapiens_hsa041400.81463904
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81112111
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.80626233
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80600414
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79823620
95Prostate cancer_Homo sapiens_hsa052150.79380478
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77847531
97Fat digestion and absorption_Homo sapiens_hsa049750.77107409
98Fatty acid elongation_Homo sapiens_hsa000620.74231286
99Dorso-ventral axis formation_Homo sapiens_hsa043200.73899382
100Proteasome_Homo sapiens_hsa030500.73640377
101beta-Alanine metabolism_Homo sapiens_hsa004100.70125233
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70008399
103Wnt signaling pathway_Homo sapiens_hsa043100.66934353
104cAMP signaling pathway_Homo sapiens_hsa040240.65888879
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65780474
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.65282792
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65093511
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64775083
109Ovarian steroidogenesis_Homo sapiens_hsa049130.63341801
110Pathways in cancer_Homo sapiens_hsa052000.63101234
111Retinol metabolism_Homo sapiens_hsa008300.62992208
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61859245
113Pancreatic secretion_Homo sapiens_hsa049720.60598910
114Small cell lung cancer_Homo sapiens_hsa052220.60515103
115Cholinergic synapse_Homo sapiens_hsa047250.60211831
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59749102
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59161361
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58874178
119Arginine and proline metabolism_Homo sapiens_hsa003300.58617970
120GABAergic synapse_Homo sapiens_hsa047270.58561577
121Inositol phosphate metabolism_Homo sapiens_hsa005620.58525296
122Other glycan degradation_Homo sapiens_hsa005110.58358894
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58301079
124Oxytocin signaling pathway_Homo sapiens_hsa049210.57400585
125Adherens junction_Homo sapiens_hsa045200.56526825
126Pentose phosphate pathway_Homo sapiens_hsa000300.52940587
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52352693
128Dopaminergic synapse_Homo sapiens_hsa047280.51358024
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.51109467
130Type II diabetes mellitus_Homo sapiens_hsa049300.50686170
131Fatty acid biosynthesis_Homo sapiens_hsa000610.50488390
132Renin secretion_Homo sapiens_hsa049240.50169009
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.49651690
134Axon guidance_Homo sapiens_hsa043600.47882756
135Gastric acid secretion_Homo sapiens_hsa049710.45956042
136Autoimmune thyroid disease_Homo sapiens_hsa053200.45064876
137Epstein-Barr virus infection_Homo sapiens_hsa051690.44229445
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43761632
139Ribosome_Homo sapiens_hsa030100.43437448
140Hematopoietic cell lineage_Homo sapiens_hsa046400.42916112
141Sulfur relay system_Homo sapiens_hsa041220.41127089
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40374306
143FoxO signaling pathway_Homo sapiens_hsa040680.39577723
144Type I diabetes mellitus_Homo sapiens_hsa049400.38988450
145Insulin resistance_Homo sapiens_hsa049310.38524371
146Choline metabolism in cancer_Homo sapiens_hsa052310.38446380
147Fatty acid degradation_Homo sapiens_hsa000710.38397034
148Bile secretion_Homo sapiens_hsa049760.35577675
149Amphetamine addiction_Homo sapiens_hsa050310.35503719
150ErbB signaling pathway_Homo sapiens_hsa040120.35381180
151Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34718663
152T cell receptor signaling pathway_Homo sapiens_hsa046600.33949449
153Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33579423
154Primary immunodeficiency_Homo sapiens_hsa053400.33321724
155Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33147102
156Ras signaling pathway_Homo sapiens_hsa040140.32436449
157Asthma_Homo sapiens_hsa053100.31854626
158NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31107901
159Metabolic pathways_Homo sapiens_hsa011000.29301890
160HTLV-I infection_Homo sapiens_hsa051660.25636807
161Graft-versus-host disease_Homo sapiens_hsa053320.24548437
162Herpes simplex infection_Homo sapiens_hsa051680.24445540
163Rheumatoid arthritis_Homo sapiens_hsa053230.24243232
164Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23232902

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