GK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lysine metabolic process (GO:0006553)6.63635468
2lysine catabolic process (GO:0006554)6.63635468
3L-phenylalanine catabolic process (GO:0006559)6.38787087
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.38787087
5aromatic amino acid family catabolic process (GO:0009074)6.19867308
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.19827548
7L-phenylalanine metabolic process (GO:0006558)6.19827548
8cysteine metabolic process (GO:0006534)6.01214437
9tryptophan catabolic process (GO:0006569)5.93933815
10indole-containing compound catabolic process (GO:0042436)5.93933815
11indolalkylamine catabolic process (GO:0046218)5.93933815
12glyoxylate metabolic process (GO:0046487)5.91055190
13urate metabolic process (GO:0046415)5.87634350
14drug transmembrane transport (GO:0006855)5.70238012
15tryptophan metabolic process (GO:0006568)5.60800091
16kynurenine metabolic process (GO:0070189)5.58076519
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.37714373
18homocysteine metabolic process (GO:0050667)5.17702026
19amino-acid betaine metabolic process (GO:0006577)5.09665447
20alpha-linolenic acid metabolic process (GO:0036109)4.95644860
21drug transport (GO:0015893)4.95503534
22drug catabolic process (GO:0042737)4.94801931
23triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.83288919
24serine family amino acid catabolic process (GO:0009071)4.83250152
25bile acid biosynthetic process (GO:0006699)4.83065307
26sulfur amino acid catabolic process (GO:0000098)4.82924693
27detection of molecule of bacterial origin (GO:0032490)4.75797403
28cellular ketone body metabolic process (GO:0046950)4.60952725
29aspartate family amino acid catabolic process (GO:0009068)4.58969504
30short-chain fatty acid metabolic process (GO:0046459)4.57422740
31positive regulation by symbiont of host defense response (GO:0052509)4.57034505
32modulation by symbiont of host defense response (GO:0052031)4.57034505
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.57034505
34modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.57034505
35positive regulation by organism of defense response of other organism involved in symbiotic interact4.57034505
36modulation by symbiont of host immune response (GO:0052553)4.57034505
37aromatic amino acid family metabolic process (GO:0009072)4.51498301
38urea cycle (GO:0000050)4.51034344
39urea metabolic process (GO:0019627)4.51034344
40alpha-amino acid catabolic process (GO:1901606)4.36398689
41negative regulation of interleukin-12 production (GO:0032695)4.35912695
42glutamate metabolic process (GO:0006536)4.35393053
43response to peptidoglycan (GO:0032494)4.35069516
44carnitine metabolic process (GO:0009437)4.34809485
45acetyl-CoA metabolic process (GO:0006084)4.30665385
462-oxoglutarate metabolic process (GO:0006103)4.29829588
47fatty acid beta-oxidation (GO:0006635)4.28511813
48cellular modified amino acid catabolic process (GO:0042219)4.24639703
49serine family amino acid metabolic process (GO:0009069)4.20355845
50exogenous drug catabolic process (GO:0042738)4.19096448
51indolalkylamine metabolic process (GO:0006586)4.17764613
52nitrogen cycle metabolic process (GO:0071941)4.17610940
53cellular amino acid catabolic process (GO:0009063)4.17065265
54fatty acid oxidation (GO:0019395)4.12235384
55positive regulation of gamma-delta T cell activation (GO:0046645)4.11234557
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.10708303
57macrophage activation involved in immune response (GO:0002281)4.09347471
58bile acid metabolic process (GO:0008206)4.08763923
59cellular biogenic amine catabolic process (GO:0042402)4.08587860
60amine catabolic process (GO:0009310)4.08587860
61lipid oxidation (GO:0034440)4.07786174
62valine metabolic process (GO:0006573)4.04780702
63regulation of triglyceride catabolic process (GO:0010896)4.02159447
64neutrophil activation involved in immune response (GO:0002283)3.99050450
65ketone body metabolic process (GO:1902224)3.98446780
66benzene-containing compound metabolic process (GO:0042537)3.98420318
67organic cation transport (GO:0015695)3.93741002
68negative regulation of cell killing (GO:0031342)3.92964633
69negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92964633
70high-density lipoprotein particle remodeling (GO:0034375)3.90033179
71fatty acid catabolic process (GO:0009062)3.89491123
72tyrosine metabolic process (GO:0006570)3.86842136
73detection of external biotic stimulus (GO:0098581)3.85079394
74carboxylic acid catabolic process (GO:0046395)3.84487774
75organic acid catabolic process (GO:0016054)3.84487774
76response to mercury ion (GO:0046689)3.83201531
77detection of other organism (GO:0098543)3.82979231
78monocarboxylic acid catabolic process (GO:0072329)3.81720928
79serine family amino acid biosynthetic process (GO:0009070)3.80827378
80branched-chain amino acid metabolic process (GO:0009081)3.80021509
81negative regulation of sterol transport (GO:0032372)3.79630653
82negative regulation of cholesterol transport (GO:0032375)3.79630653
83phosphate ion transport (GO:0006817)3.79317250
84cellular extravasation (GO:0045123)3.78859386
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78034365
86dicarboxylic acid biosynthetic process (GO:0043650)3.77956425
87quaternary ammonium group transport (GO:0015697)3.77452060
88regulation of cholesterol esterification (GO:0010872)3.75350223
89cellular glucuronidation (GO:0052695)3.75184769
90aldehyde catabolic process (GO:0046185)3.71810307
91ethanol oxidation (GO:0006069)3.71482944
92phosphate ion transmembrane transport (GO:0035435)3.71443775
93complement activation, alternative pathway (GO:0006957)3.71343450
94branched-chain amino acid catabolic process (GO:0009083)3.67491167
95protein carboxylation (GO:0018214)3.67254258
96peptidyl-glutamic acid carboxylation (GO:0017187)3.67254258
97aminoglycoside antibiotic metabolic process (GO:0030647)3.67232605
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.65251856
99acylglycerol homeostasis (GO:0055090)3.60336493
100triglyceride homeostasis (GO:0070328)3.60336493
101plasma lipoprotein particle remodeling (GO:0034369)3.59482334
102protein-lipid complex remodeling (GO:0034368)3.59482334
103macromolecular complex remodeling (GO:0034367)3.59482334
104lipopolysaccharide-mediated signaling pathway (GO:0031663)3.59426267
105regulation of interferon-beta biosynthetic process (GO:0045357)3.58984128
106coenzyme catabolic process (GO:0009109)3.58409693
107flavonoid metabolic process (GO:0009812)3.58332068
108reverse cholesterol transport (GO:0043691)3.57314703
109glucuronate metabolic process (GO:0019585)3.56705516
110uronic acid metabolic process (GO:0006063)3.56705516
111tricarboxylic acid metabolic process (GO:0072350)3.56420263
112fructose metabolic process (GO:0006000)3.56367257
113immunoglobulin mediated immune response (GO:0016064)3.53121956
114regulation of protein activation cascade (GO:2000257)3.52652295
115negative regulation of fibrinolysis (GO:0051918)3.50824400
116amino-acid betaine transport (GO:0015838)3.49048792
117carnitine transport (GO:0015879)3.49048792
118response to phenylpropanoid (GO:0080184)3.45386924
119positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.43981197
120phospholipid efflux (GO:0033700)3.43222807
121glycine metabolic process (GO:0006544)3.43093477
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42820976
123drug metabolic process (GO:0017144)3.41717004
124detection of biotic stimulus (GO:0009595)3.41624917
125phospholipid homeostasis (GO:0055091)3.41584216
126biotin metabolic process (GO:0006768)3.40403034
127antigen processing and presentation of endogenous antigen (GO:0019883)3.40370207
128detection of bacterium (GO:0016045)3.36993936
129production of molecular mediator involved in inflammatory response (GO:0002532)3.34683032
130microglial cell activation (GO:0001774)3.28861281
131plasma lipoprotein particle assembly (GO:0034377)3.27284286
132macrophage activation (GO:0042116)3.21074455
133low-density lipoprotein particle remodeling (GO:0034374)3.19224885
134very-low-density lipoprotein particle assembly (GO:0034379)3.17890849
135T-helper 1 type immune response (GO:0042088)3.14883026
136germinal center formation (GO:0002467)3.10357008
137angiotensin maturation (GO:0002003)3.06391311
138response to host immune response (GO:0052572)3.04501664
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04501664
140regulation of interferon-alpha production (GO:0032647)3.03794314
141regulation of T-helper 2 cell differentiation (GO:0045628)3.03450166
142type I interferon signaling pathway (GO:0060337)3.03080987
143cellular response to type I interferon (GO:0071357)3.03080987
144interferon-gamma-mediated signaling pathway (GO:0060333)3.02599113
145positive regulation of cellular amide metabolic process (GO:0034250)3.02456774
146neutrophil activation (GO:0042119)2.99338495
147response to type I interferon (GO:0034340)2.98910531
148protein-lipid complex assembly (GO:0065005)2.97901244
149positive regulation of interferon-alpha production (GO:0032727)2.97407070
150regulation of gamma-delta T cell activation (GO:0046643)2.97224332
151positive regulation of type 2 immune response (GO:0002830)2.96626764
152leukocyte migration involved in inflammatory response (GO:0002523)2.94763728
153regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.94257221
154positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93994172
155B cell mediated immunity (GO:0019724)2.93587003
156granulocyte activation (GO:0036230)2.93456636
157defense response to protozoan (GO:0042832)2.91120256
158regulation of interleukin-8 biosynthetic process (GO:0045414)2.90429540
159regulation of tolerance induction (GO:0002643)2.89579751
160regulation of vitamin metabolic process (GO:0030656)2.85785838
161respiratory burst (GO:0045730)2.85564121
162negative regulation of cytokine production involved in immune response (GO:0002719)2.84556295
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82001937
164regulation of T-helper 1 cell differentiation (GO:0045625)2.81743535
165glycosphingolipid catabolic process (GO:0046479)2.79470012
166regulation of cytokine secretion involved in immune response (GO:0002739)2.79360380
167regulation of vitamin D biosynthetic process (GO:0060556)2.77580415
168negative regulation of lymphocyte mediated immunity (GO:0002707)2.77474606
169response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.77355949
170response to host (GO:0075136)2.77355949
171response to host defenses (GO:0052200)2.77355949
172regulation of T cell tolerance induction (GO:0002664)2.77164465
173response to interleukin-15 (GO:0070672)2.74280001
174myeloid dendritic cell differentiation (GO:0043011)2.70418261
175neutrophil mediated immunity (GO:0002446)2.69876907
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.69609278
177regulation of mast cell degranulation (GO:0043304)2.69237294
178myeloid cell activation involved in immune response (GO:0002275)2.68140311
179negative regulation of protein activation cascade (GO:2000258)2.66869670
180response to protozoan (GO:0001562)2.66373758
181positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65984630
182regulation of B cell receptor signaling pathway (GO:0050855)2.65426091
183positive regulation of tolerance induction (GO:0002645)2.64848066
184positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.64354285
185positive regulation of acute inflammatory response (GO:0002675)2.62832660
186regulation of podosome assembly (GO:0071801)2.61654998
187positive regulation of NF-kappaB import into nucleus (GO:0042346)2.61277859
188negative regulation of myeloid cell apoptotic process (GO:0033033)2.59665511
189regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58727689
190leukocyte aggregation (GO:0070486)2.57573251
191negative regulation of complement activation (GO:0045916)2.57146465
192cholesterol efflux (GO:0033344)2.56982962
193regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.56328200
194glycolipid catabolic process (GO:0019377)2.55400131
195peptide catabolic process (GO:0043171)2.54272345
196negative regulation of humoral immune response (GO:0002921)2.54260627
197oligosaccharide catabolic process (GO:0009313)2.53339547
198regulation of toll-like receptor signaling pathway (GO:0034121)2.52588279
199dendritic cell chemotaxis (GO:0002407)2.52108164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.32541591
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.24647200
3LXR_22158963_ChIP-Seq_LIVER_Mouse5.77309870
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.59319661
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.43792548
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.33345562
7BP1_19119308_ChIP-ChIP_Hs578T_Human4.03738752
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90148664
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.75172824
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.48710551
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.24481478
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96497511
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.95055105
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92318805
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.82741453
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73824150
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50607017
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32160926
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21558413
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.17998095
21RUNX_20019798_ChIP-Seq_JUKART_Human2.14167782
22SPI1_23547873_ChIP-Seq_NB4_Human2.02495721
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0963589
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.99249469
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97274225
26SPI1_23127762_ChIP-Seq_K562_Human1.96029538
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89656466
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87584336
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.74058705
30CLOCK_20551151_ChIP-Seq_293T_Human1.73161576
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72609304
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72075306
33MYB_26560356_Chip-Seq_TH2_Human1.67192274
34VDR_24763502_ChIP-Seq_THP-1_Human1.63260958
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62974095
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57030391
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56108534
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.54431452
39SCL_19346495_ChIP-Seq_HPC-7_Human1.52595564
40PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51603248
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51229492
42CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51203795
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.48379228
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.48194800
45PU_27001747_Chip-Seq_BMDM_Mouse1.48028535
46PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.47155461
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45675997
48ESR1_21235772_ChIP-Seq_MCF-7_Human1.45244653
49STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43973728
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.43909933
51ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42002984
52* MYB_26560356_Chip-Seq_TH1_Human1.41535797
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40851057
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.40448336
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35818566
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31791523
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29002419
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.28921577
59CDX2_20551321_ChIP-Seq_CACO-2_Human1.27574900
60GATA4_25053715_ChIP-Seq_YYC3_Human1.26926177
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26177747
62MAF_26560356_Chip-Seq_TH1_Human1.26129681
63GATA3_27048872_Chip-Seq_THYMUS_Human1.25971946
64CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25525472
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23968787
66SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21507083
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.20895719
68RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.20843299
69* GATA3_26560356_Chip-Seq_TH2_Human1.19773565
70GATA1_22025678_ChIP-Seq_K562_Human1.16864578
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16072988
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14330002
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13623834
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12620752
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11150455
76PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08421407
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06907381
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06647817
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04326495
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04186832
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.00720962
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00716271
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99552193
84NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97357096
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96803439
86NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96803439
87HTT_18923047_ChIP-ChIP_STHdh_Human0.96217239
88AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95493712
89PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94647856
90UTX_26944678_Chip-Seq_JUKART_Human0.94542651
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93990931
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93529050
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92702083
94PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92038886
95TCF7_22412390_ChIP-Seq_EML_Mouse0.91107503
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89447637
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87561041
98VDR_21846776_ChIP-Seq_THP-1_Human0.86507905
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.85702840
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85192179
101EGR1_19032775_ChIP-ChIP_M12_Human0.84996673
102FOXO3_23340844_ChIP-Seq_DLD1_Human0.84874513
103RXRA_24833708_ChIP-Seq_LIVER_Mouse0.84258083
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83017324
105* SOX2_20726797_ChIP-Seq_SW620_Human0.79629552
106PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79585541
107CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79332300
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78050143
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.77954445
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72926948
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71063655
112BCAT_22108803_ChIP-Seq_LS180_Human0.70629434
113IRF8_27001747_Chip-Seq_BMDM_Mouse0.69956519
114CDX2_22108803_ChIP-Seq_LS180_Human0.69845129
115GATA6_25053715_ChIP-Seq_YYC3_Human0.69825823
116GATA2_19941826_ChIP-Seq_K562_Human0.69758329
117GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68412371
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67092183
119RXR_22108803_ChIP-Seq_LS180_Human0.66469390
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66423304
121BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.66009991
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.65575690
123STAT1_17558387_ChIP-Seq_HELA_Human0.64597070
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63280816
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.63110033
126CEBPB_22108803_ChIP-Seq_LS180_Human0.62437651
127VDR_22108803_ChIP-Seq_LS180_Human0.62082008
128AR_20517297_ChIP-Seq_VCAP_Human0.61988538
129FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.61839238
130RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61050432
131AR_21909140_ChIP-Seq_LNCAP_Human0.60675585
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60636115
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.59438661
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.59413994
135IRF8_21731497_ChIP-ChIP_J774_Mouse0.59191080
136MYC_19915707_ChIP-ChIP_AK7_Human0.58516163
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.57968953
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57912948
139TP63_23658742_ChIP-Seq_EP156T_Human0.57718304
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.56308222
141FOXA1_25552417_ChIP-Seq_VCAP_Human0.55994207
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.55692002
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.55686879
144CBP_21632823_ChIP-Seq_H3396_Human0.55583550
145TAF2_19829295_ChIP-Seq_ESCs_Human0.55424181
146VDR_24787735_ChIP-Seq_THP-1_Human0.54384196
147SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.53761540
148ESET_19884257_ChIP-Seq_ESCs_Mouse0.53262854
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.50082739
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48954664
151GATA1_19941826_ChIP-Seq_K562_Human0.48921133
152GATA3_24758297_ChIP-Seq_MCF-7_Human0.48720163
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.48181724
154TBX20_22080862_ChIP-Seq_HEART_Mouse0.48134457
155TBX20_22328084_ChIP-Seq_HEART_Mouse0.48134457
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.47996389
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47844133
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.47416670

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.40999599
2MP0002139_abnormal_hepatobiliary_system7.19223127
3MP0005085_abnormal_gallbladder_physiolo5.18129657
4MP0005365_abnormal_bile_salt4.95108441
5MP0008875_abnormal_xenobiotic_pharmacok4.54202936
6MP0003303_peritoneal_inflammation4.23039437
7MP0005332_abnormal_amino_acid3.82429220
8MP0003195_calcinosis3.59998059
9MP0003252_abnormal_bile_duct3.50604874
10MP0004019_abnormal_vitamin_homeostasis3.33593204
11MP0003806_abnormal_nucleotide_metabolis3.26404768
12MP0001835_abnormal_antigen_presentation3.15484592
13MP0010329_abnormal_lipoprotein_level2.99208109
14MP0009785_altered_susceptibility_to2.95024472
15MP0004043_abnormal_pH_regulation2.61414362
16MP0002419_abnormal_innate_immunity2.58482411
17MP0009840_abnormal_foam_cell2.53559572
18MP0002148_abnormal_hypersensitivity_rea2.51145396
19MP0001666_abnormal_nutrient_absorption2.47312394
20MP0002138_abnormal_hepatobiliary_system2.44292291
21MP0005025_abnormal_response_to2.43206143
22MP0005387_immune_system_phenotype2.39739310
23MP0001790_abnormal_immune_system2.39739310
24MP0005000_abnormal_immune_tolerance2.35589238
25MP0009643_abnormal_urine_homeostasis2.28248744
26MP0003191_abnormal_cellular_cholesterol2.23059386
27MP0000685_abnormal_immune_system2.18571247
28MP0003172_abnormal_lysosome_physiology2.15285963
29MP0001800_abnormal_humoral_immune2.13196304
30MP0005083_abnormal_biliary_tract2.09115646
31MP0010155_abnormal_intestine_physiology2.07876593
32MP0005671_abnormal_response_to2.05728806
33MP0002723_abnormal_immune_serum2.01654245
34MP0002452_abnormal_antigen_presenting1.98382937
35MP0002118_abnormal_lipid_homeostasis1.93614819
36MP0001533_abnormal_skeleton_physiology1.90604203
37MP0005319_abnormal_enzyme/_coenzyme1.83598503
38MP0008260_abnormal_autophagy1.83436428
39MP0000609_abnormal_liver_physiology1.80713890
40MP0005584_abnormal_enzyme/coenzyme_acti1.78612795
41MP0003183_abnormal_peptide_metabolism1.74229723
42MP0005636_abnormal_mineral_homeostasis1.74043954
43MP0002420_abnormal_adaptive_immunity1.71314452
44MP0001819_abnormal_immune_cell1.71049481
45MP0005451_abnormal_body_composition1.66662549
46MP0003186_abnormal_redox_activity1.65843894
47MP0004947_skin_inflammation1.63751560
48MP0001764_abnormal_homeostasis1.62530170
49MP0002405_respiratory_system_inflammati1.61040306
50MP0008004_abnormal_stomach_pH1.59810249
51MP0006054_spinal_hemorrhage1.58584933
52MP0001756_abnormal_urination1.56477870
53MP0002132_abnormal_respiratory_system1.49875454
54MP0001765_abnormal_ion_homeostasis1.48797838
55MP0005164_abnormal_response_to1.46103039
56MP0002136_abnormal_kidney_physiology1.44378722
57MP0000858_altered_metastatic_potential1.41046024
58MP0004883_abnormal_blood_vessel1.39127313
59MP0005310_abnormal_salivary_gland1.37573711
60MP0004510_myositis1.34848640
61MP0002998_abnormal_bone_remodeling1.32236824
62MP0000343_altered_response_to1.29642951
63MP0009333_abnormal_splenocyte_physiolog1.28298772
64MP0003866_abnormal_defecation1.27604232
65MP0005670_abnormal_white_adipose1.25205683
66MP0000716_abnormal_immune_system1.24655032
67MP0009764_decreased_sensitivity_to1.22692740
68MP0003868_abnormal_feces_composition1.20039931
69MP0002876_abnormal_thyroid_physiology1.19436631
70MP0000465_gastrointestinal_hemorrhage1.18399629
71MP0005397_hematopoietic_system_phenotyp1.17396536
72MP0001545_abnormal_hematopoietic_system1.17396536
73MP0006036_abnormal_mitochondrial_physio1.17284320
74MP0005535_abnormal_body_temperature1.14011780
75MP0009278_abnormal_bone_marrow1.13036326
76MP0002398_abnormal_bone_marrow1.10354841
77MP0005058_abnormal_lysosome_morphology1.09997970
78MP0005084_abnormal_gallbladder_morpholo1.07386577
79MP0003448_altered_tumor_morphology1.04987791
80MP0000604_amyloidosis1.04713198
81MP0002277_abnormal_respiratory_mucosa1.04557923
82MP0003828_pulmonary_edema1.00487235
83MP0000689_abnormal_spleen_morphology0.99370804
84MP0002429_abnormal_blood_cell0.97510095
85MP0009697_abnormal_copulation0.97115566
86MP0005377_hearing/vestibular/ear_phenot0.96104993
87MP0003878_abnormal_ear_physiology0.96104993
88MP0000598_abnormal_liver_morphology0.95664571
89MP0008469_abnormal_protein_level0.95345752
90MP0002722_abnormal_immune_system0.93958997
91MP0009642_abnormal_blood_homeostasis0.91608048
92MP0002971_abnormal_brown_adipose0.90616471
93MP0003656_abnormal_erythrocyte_physiolo0.89127239
94MP0005666_abnormal_adipose_tissue0.86360391
95MP0002254_reproductive_system_inflammat0.85383824
96MP0002166_altered_tumor_susceptibility0.85174996
97MP0003453_abnormal_keratinocyte_physiol0.84756284
98MP0000249_abnormal_blood_vessel0.84616305
99MP0004130_abnormal_muscle_cell0.84320743
100MP0001663_abnormal_digestive_system0.82440612
101MP0003011_delayed_dark_adaptation0.80648061
102MP0009763_increased_sensitivity_to0.80390407
103MP0010352_gastrointestinal_tract_polyps0.80153003
104MP0000538_abnormal_urinary_bladder0.79935062
105MP0003724_increased_susceptibility_to0.79619770
106MP0003763_abnormal_thymus_physiology0.78474519
107MP0003690_abnormal_glial_cell0.77801848
108MP0005647_abnormal_sex_gland0.77764476
109MP0002078_abnormal_glucose_homeostasis0.77256962
110MP0002006_tumorigenesis0.75255581
111MP0005376_homeostasis/metabolism_phenot0.73496038
112MP0001851_eye_inflammation0.73044930
113MP0005408_hypopigmentation0.72771072
114MP0003646_muscle_fatigue0.71716941
115MP0003705_abnormal_hypodermis_morpholog0.71326894
116MP0000230_abnormal_systemic_arterial0.71149111
117MP0005409_darkened_coat_color0.70843806
118MP0000920_abnormal_myelination0.69074199
119MP0002168_other_aberrant_phenotype0.68059957
120MP0004147_increased_porphyrin_level0.67886886
121MP0001661_extended_life_span0.67174813
122MP0005395_other_phenotype0.67120405
123MP0003075_altered_response_to0.66037806
124MP0003300_gastrointestinal_ulcer0.65130749
125MP0005167_abnormal_blood-brain_barrier0.64550658
126MP0003329_amyloid_beta_deposits0.64113087
127MP0003638_abnormal_response/metabolism_0.64005704
128MP0005334_abnormal_fat_pad0.63787354
129MP0002933_joint_inflammation0.63002506
130MP0000569_abnormal_digit_pigmentation0.62637521
131MP0004264_abnormal_extraembryonic_tissu0.61443115
132MP0009765_abnormal_xenobiotic_induced0.60980621
133MP0005166_decreased_susceptibility_to0.59565812
134MP0005266_abnormal_metabolism0.59336021
135MP0006035_abnormal_mitochondrial_morpho0.58092797
136MP0001881_abnormal_mammary_gland0.57838953
137MP0002928_abnormal_bile_duct0.57136852
138MP0008961_abnormal_basal_metabolism0.56720152
139MP0001958_emphysema0.56329124
140MP0010234_abnormal_vibrissa_follicle0.55738056
141MP0002135_abnormal_kidney_morphology0.52691469
142MP0002796_impaired_skin_barrier0.49122683
143MP0003718_maternal_effect0.47761440
144MP0003953_abnormal_hormone_level0.47522818
145MP0009115_abnormal_fat_cell0.47400334
146MP0006082_CNS_inflammation0.47158682
147MP0005220_abnormal_exocrine_pancreas0.45003954
148MP0004782_abnormal_surfactant_physiolog0.44072100
149MP0003436_decreased_susceptibility_to0.44066337
150MP0005448_abnormal_energy_balance0.44002769
151MP0001845_abnormal_inflammatory_respons0.43963146
152MP0005464_abnormal_platelet_physiology0.41470787
153MP0008872_abnormal_physiological_respon0.39766660
154MP0008874_decreased_physiological_sensi0.39298657
155MP0002837_dystrophic_cardiac_calcinosis0.37317256
156MP0004885_abnormal_endolymph0.34989330
157MP0001853_heart_inflammation0.33499545
158MP0005165_increased_susceptibility_to0.33041809
159MP0008873_increased_physiological_sensi0.32561999

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.53924216
2Abnormality of glutamine family amino acid metabolism (HP:0010902)5.47357304
3Eczematoid dermatitis (HP:0000976)5.32139175
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.29428803
5Orchitis (HP:0100796)5.12455229
6Optic neuritis (HP:0100653)5.03158591
7Retrobulbar optic neuritis (HP:0100654)5.03158591
8Intrahepatic cholestasis (HP:0001406)4.95657190
9Recurrent bacterial skin infections (HP:0005406)4.93654820
10Gout (HP:0001997)4.91768892
11Abnormality of glycine metabolism (HP:0010895)4.88596016
12Abnormality of serine family amino acid metabolism (HP:0010894)4.88596016
13Xanthomatosis (HP:0000991)4.81415296
14Myositis (HP:0100614)4.73898310
15Recurrent gram-negative bacterial infections (HP:0005420)4.73182774
16Abnormality of macrophages (HP:0004311)4.65996416
17Recurrent abscess formation (HP:0002722)4.59267699
18Abnormality of monocarboxylic acid metabolism (HP:0010996)4.47690998
19Deep venous thrombosis (HP:0002625)4.45329267
20Hyperammonemia (HP:0001987)4.44000782
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.29576705
22Hyperglycinemia (HP:0002154)4.20345844
23* Ketosis (HP:0001946)4.17542128
24Abnormality of purine metabolism (HP:0004352)4.14179059
25Proximal tubulopathy (HP:0000114)4.10159966
26Abnormality of fatty-acid metabolism (HP:0004359)4.08208287
27Hypobetalipoproteinemia (HP:0003563)4.05336578
28Abnormality of sulfur amino acid metabolism (HP:0004339)3.88071677
29Hypokalemic alkalosis (HP:0001949)3.85420194
30Increased circulating renin level (HP:0000848)3.81350294
31Gastrointestinal infarctions (HP:0005244)3.78424985
32Metabolic alkalosis (HP:0200114)3.78247849
33Gingival bleeding (HP:0000225)3.75040436
34Prolonged partial thromboplastin time (HP:0003645)3.74839336
35Hyperuricemia (HP:0002149)3.70172348
36Increased purine levels (HP:0004368)3.70172348
37Abnormality of nucleobase metabolism (HP:0010932)3.69403033
38Hyperactive renin-angiotensin system (HP:0000841)3.67732650
39Keratoconjunctivitis sicca (HP:0001097)3.59143256
40Stomatitis (HP:0010280)3.58923581
41Hyperlipoproteinemia (HP:0010980)3.58414021
42Alkalosis (HP:0001948)3.54616006
43* Ketoacidosis (HP:0001993)3.54039004
44Hypoglycemic coma (HP:0001325)3.49522342
45Generalized aminoaciduria (HP:0002909)3.36873371
46Hypomagnesemia (HP:0002917)3.36299084
47Mediastinal lymphadenopathy (HP:0100721)3.34688151
48Abnormal urine output (HP:0012590)3.30029497
49Glomerulonephritis (HP:0000099)3.27351059
50Complement deficiency (HP:0004431)3.27020621
51Keratoconjunctivitis (HP:0001096)3.25995197
52Joint hemorrhage (HP:0005261)3.25774825
53Abnormality of proline metabolism (HP:0010907)3.22785473
54Hydroxyprolinuria (HP:0003080)3.22785473
55Purpura (HP:0000979)3.20710677
56Hypolipoproteinemia (HP:0010981)3.20503531
57Delayed CNS myelination (HP:0002188)3.20455563
58Abnormality of chloride homeostasis (HP:0011422)3.19388028
59Polyuria (HP:0000103)3.16454473
60Epidermoid cyst (HP:0200040)3.14015644
61Abnormality of renal excretion (HP:0011036)3.12295849
62Abnormality of dicarboxylic acid metabolism (HP:0010995)3.11384827
63Dicarboxylic aciduria (HP:0003215)3.11384827
64Vasculitis (HP:0002633)3.10609160
65Recurrent skin infections (HP:0001581)3.10555430
66Vascular calcification (HP:0004934)3.10449650
67Glycosuria (HP:0003076)3.06896698
68Abnormality of urine glucose concentration (HP:0011016)3.06896698
69Fat malabsorption (HP:0002630)3.06396226
70Abnormality of glycolipid metabolism (HP:0010969)3.04708645
71Abnormality of liposaccharide metabolism (HP:0010968)3.04708645
72Abnormality of glycosphingolipid metabolism (HP:0004343)3.04708645
73Elevated erythrocyte sedimentation rate (HP:0003565)3.04559387
74Amyloidosis (HP:0011034)3.00803836
75* Metabolic acidosis (HP:0001942)3.00564695
76Gangrene (HP:0100758)3.00286638
77Gingivitis (HP:0000230)2.99521025
78Obstructive lung disease (HP:0006536)2.97068255
79Chronic obstructive pulmonary disease (HP:0006510)2.97068255
80Arterial thrombosis (HP:0004420)2.94443671
81Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93416993
82Hypoalphalipoproteinemia (HP:0003233)2.90313156
83Abnormality of serum amino acid levels (HP:0003112)2.90085774
84Abnormality of methionine metabolism (HP:0010901)2.88330811
85Prolonged bleeding time (HP:0003010)2.88014026
86Recurrent fungal infections (HP:0002841)2.85987681
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84871047
88Pulmonary infiltrates (HP:0002113)2.82353072
89Peritonitis (HP:0002586)2.82209691
90Acanthocytosis (HP:0001927)2.81913442
91Abnormality of magnesium homeostasis (HP:0004921)2.80919826
92Abnormality of pyrimidine metabolism (HP:0004353)2.79850982
93Abnormality of the common coagulation pathway (HP:0010990)2.78527144
94Epistaxis (HP:0000421)2.76791601
95Episodic fever (HP:0001954)2.75692326
96Conjugated hyperbilirubinemia (HP:0002908)2.74025212
97Cardiovascular calcification (HP:0011915)2.72578335
98* Lethargy (HP:0001254)2.71435557
99Encephalitis (HP:0002383)2.69888759
100Pulmonary embolism (HP:0002204)2.69716659
101Vacuolated lymphocytes (HP:0001922)2.66996231
102Autoimmune thrombocytopenia (HP:0001973)2.64117709
103Hemoptysis (HP:0002105)2.64038811
104Malnutrition (HP:0004395)2.63689280
105Meningitis (HP:0001287)2.58717173
106Renal tubular acidosis (HP:0001947)2.58277132
107Urticaria (HP:0001025)2.56707094
108Tetany (HP:0001281)2.56593765
109* Vomiting (HP:0002013)2.55186129
110Spontaneous hematomas (HP:0007420)2.52627362
111Anorexia (HP:0002039)2.52077674
112Hypercholesterolemia (HP:0003124)2.49966415
113Hepatocellular carcinoma (HP:0001402)2.49388226
114Abnormality of T cell number (HP:0011839)2.45972232
115Disinhibition (HP:0000734)2.45827468
116Loss of speech (HP:0002371)2.45458865
117Menorrhagia (HP:0000132)2.44894047
118Joint swelling (HP:0001386)2.44864405
119Hyperbilirubinemia (HP:0002904)2.44623421
120Enlarged kidneys (HP:0000105)2.41976887
121Dysostosis multiplex (HP:0000943)2.40203304
122Nausea (HP:0002018)2.39625753
123Rickets (HP:0002748)2.39394501
124Thrombophlebitis (HP:0004418)2.39289757
125Polydipsia (HP:0001959)2.39228090
126Abnormal drinking behavior (HP:0030082)2.39228090
127Hyperaldosteronism (HP:0000859)2.37778684
128Irritability (HP:0000737)2.36608544
129Increased IgM level (HP:0003496)2.36429502
130Abnormality of the peritoneum (HP:0002585)2.36213054
131T lymphocytopenia (HP:0005403)2.35564460
132Confusion (HP:0001289)2.34584028
133Petechiae (HP:0000967)2.33888647
134Hyperphosphaturia (HP:0003109)2.33128625
135Cerebral edema (HP:0002181)2.31840376
136Sensorimotor neuropathy (HP:0007141)2.30951092
137Nephrolithiasis (HP:0000787)2.30523013
138Renal salt wasting (HP:0000127)2.30288434
139Abnormality of complement system (HP:0005339)2.29248112
140Increased cerebral lipofuscin (HP:0011813)2.28417204
141Abnormality of renin-angiotensin system (HP:0000847)2.27597007
142Abnormality of the pleura (HP:0002103)2.26292171
143Chronic diarrhea (HP:0002028)2.25123437
144Abnormal delayed hypersensitivity skin test (HP:0002963)2.24831129
145Spastic diplegia (HP:0001264)2.24025064
146Metaphyseal irregularity (HP:0003025)2.23637879
147Increased serum ferritin (HP:0003281)2.23425118
148Systemic lupus erythematosus (HP:0002725)2.22077516
149Abnormality of the intrinsic pathway (HP:0010989)2.20484397
150Steatorrhea (HP:0002570)2.18593762
151Glomerulopathy (HP:0100820)2.18502877
152Hemorrhage of the eye (HP:0011885)2.16445149
153Pancreatitis (HP:0001733)2.15545605
154Chest pain (HP:0100749)2.12539477
155Neonatal onset (HP:0003623)2.12041047
156Leukocytosis (HP:0001974)2.12014257
157Widely patent fontanelles and sutures (HP:0004492)2.11588508
158Abnormal urine phosphate concentration (HP:0012599)2.11507105
159Abnormality of polysaccharide metabolism (HP:0011012)2.09825192
160Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09825192
161Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09825192
162Abnormal enzyme/coenzyme activity (HP:0012379)2.09744423
163Hypophosphatemia (HP:0002148)2.09411752
164Urinary glycosaminoglycan excretion (HP:0003541)2.07772302
165Mucopolysacchariduria (HP:0008155)2.07772302
166Recurrent viral infections (HP:0004429)2.07379968
167Polyneuropathy (HP:0001271)2.05983508
168Increased IgE level (HP:0003212)2.05268759
169Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04854729
170Myocardial infarction (HP:0001658)2.04816791
171Abnormality of iron homeostasis (HP:0011031)2.03082277
172Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.02607519
173Recurrent cutaneous fungal infections (HP:0011370)2.00776060
174Chronic mucocutaneous candidiasis (HP:0002728)2.00776060
175Autoimmune hemolytic anemia (HP:0001890)2.00417577
176Nephritis (HP:0000123)1.93051758
177Spontaneous abortion (HP:0005268)1.90880777
178Abnormality of alkaline phosphatase activity (HP:0004379)1.90752280
179Late onset (HP:0003584)1.88775698
180Skin nodule (HP:0200036)1.88680618
181Potter facies (HP:0002009)1.88657981
182Facial shape deformation (HP:0011334)1.88657981
183Methylmalonic aciduria (HP:0012120)1.88596660
184Acute hepatic failure (HP:0006554)1.85706359
185Acne (HP:0001061)1.84965867
186Cellulitis (HP:0100658)1.83983840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.84297455
2BCKDK5.54324394
3WNK44.88846694
4OXSR14.85994302
5IRAK42.87671306
6BLK2.86814664
7ERN12.57714882
8SIK12.53117429
9FGFR42.52720532
10ACVR1B2.45744480
11MST1R2.44715744
12FGR2.39285926
13MAP4K12.22817852
14STK38L2.19221671
15ERBB42.04968515
16PDK41.93833870
17PDK31.93833870
18ZAP701.90880052
19STK391.86457711
20JAK31.86116784
21TXK1.82988048
22IRAK11.76228477
23INSRR1.71405403
24NEK11.68623441
25TAOK11.66968929
26BMPR21.65288743
27FRK1.61857878
28TAOK31.42041422
29MAP3K141.41260453
30SYK1.40634289
31PDK21.40482701
32MAP3K11.37652577
33IKBKB1.37549013
34SGK4941.33642813
35SGK2231.33642813
36LATS11.30354585
37LYN1.30286257
38MAP2K41.29836846
39IRAK31.28699815
40MAPK111.27299366
41PRKAA21.26972227
42EPHA31.22929943
43DDR21.22238567
44GRK71.21680945
45GRK61.21214710
46STK241.20731345
47HCK1.20467520
48ABL21.19584609
49SGK21.18337174
50IRAK21.18006773
51TRIB31.15847246
52SGK31.15552967
53PINK11.13808019
54YES11.10413802
55BTK1.09080726
56MST41.08724729
57CDC42BPA1.08261019
58TYK21.07573328
59PRPF4B1.05451030
60RIPK11.04506317
61CAMK1D1.02271901
62NEK91.01471654
63MAP3K131.01434648
64PKN21.01407303
65PTK60.99532598
66FES0.98860672
67CSF1R0.96262438
68MAP3K30.96042361
69TBK10.95972983
70MAP3K70.91490880
71LCK0.90506357
72JAK20.88378249
73EPHB10.83996659
74PRKAA10.81037989
75DAPK20.79903315
76MAP2K30.78236466
77PDPK10.77868376
78MET0.77303685
79STK380.75714069
80GSK3A0.73029094
81SIK30.72978169
82PIK3CG0.72719464
83TIE10.71216192
84ITK0.70384495
85MARK30.69836462
86NLK0.69798368
87CHUK0.69125256
88FLT30.68419593
89JAK10.64350227
90MAP3K110.63242350
91MAPK120.62107365
92CAMK1G0.61516464
93PRKCZ0.61196406
94TEC0.60988349
95PRKACG0.57024288
96WNK10.56958362
97EPHA40.55360000
98MAP3K50.54095654
99ADRBK20.53629712
100RIPK40.53156903
101BMX0.52786546
102PIM10.52289906
103RET0.52239851
104TNK20.50943657
105PDK10.49646794
106TGFBR20.48633740
107MAPK40.47886254
108FYN0.47221486
109IKBKE0.46375950
110MAP2K10.45075469
111MAP3K60.44491550
112CSK0.43668920
113PTK20.41926254
114ERBB20.40829461
115SGK10.40627514
116PBK0.37960732
117TAOK20.37430862
118MYLK0.37095610
119AKT30.36093469
120KSR20.35992552
121MAPKAPK20.35836331
122PDGFRB0.35510881
123STK30.35377103
124DYRK30.35193830
125MAP2K60.33486776
126KIT0.33275616
127ALK0.33026109
128PRKG20.32474157
129PRKCD0.32363568
130PRKCQ0.31826261
131LRRK20.31716720
132MARK20.31645146
133CDK60.30874526
134IGF1R0.30638967
135CAMK2G0.30567235
136PDGFRA0.30236880
137GRK10.29221700
138TYRO30.29103100
139PRKCA0.28401889
140KDR0.27242390
141STK100.26463671
142MAP3K120.26313992
143HIPK20.26186125
144KSR10.25667786
145PIK3CA0.24968999
146MAP3K20.24938436
147EGFR0.24873052
148LMTK20.23572094
149FGFR30.22067516
150DYRK1B0.18556321
151MATK0.18541837
152ABL10.18465842

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.32513693
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.23268478
3Nitrogen metabolism_Homo sapiens_hsa009103.07239240
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.93869918
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.85940356
6Fatty acid degradation_Homo sapiens_hsa000712.83969057
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81039880
8Leishmaniasis_Homo sapiens_hsa051402.77793233
9Butanoate metabolism_Homo sapiens_hsa006502.72309236
10Propanoate metabolism_Homo sapiens_hsa006402.68504578
11Arginine biosynthesis_Homo sapiens_hsa002202.62415436
12Tryptophan metabolism_Homo sapiens_hsa003802.61407997
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48805168
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.48569124
15Osteoclast differentiation_Homo sapiens_hsa043802.46034980
16Peroxisome_Homo sapiens_hsa041462.38350698
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32521615
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26434289
19Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23223758
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.20711389
21Fatty acid metabolism_Homo sapiens_hsa012122.18185545
22NOD-like receptor signaling pathway_Homo sapiens_hsa046212.08949358
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.02031539
24Tuberculosis_Homo sapiens_hsa051522.01516558
25Allograft rejection_Homo sapiens_hsa053302.01242991
26* PPAR signaling pathway_Homo sapiens_hsa033201.95457339
27Pertussis_Homo sapiens_hsa051331.94380284
28Graft-versus-host disease_Homo sapiens_hsa053321.93977287
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.92718860
30beta-Alanine metabolism_Homo sapiens_hsa004101.91651608
31Legionellosis_Homo sapiens_hsa051341.90774491
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89897944
33Pyruvate metabolism_Homo sapiens_hsa006201.82027413
34Complement and coagulation cascades_Homo sapiens_hsa046101.79374780
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.76961373
36Malaria_Homo sapiens_hsa051441.73268895
37TNF signaling pathway_Homo sapiens_hsa046681.72838865
38Bile secretion_Homo sapiens_hsa049761.70002349
39Autoimmune thyroid disease_Homo sapiens_hsa053201.65399687
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.65041523
41Rheumatoid arthritis_Homo sapiens_hsa053231.62978478
42Vitamin digestion and absorption_Homo sapiens_hsa049771.62357886
43Histidine metabolism_Homo sapiens_hsa003401.62108592
44Sulfur metabolism_Homo sapiens_hsa009201.57659244
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55919621
46Hematopoietic cell lineage_Homo sapiens_hsa046401.55419254
47Asthma_Homo sapiens_hsa053101.54514717
48Type I diabetes mellitus_Homo sapiens_hsa049401.53743200
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53244012
50Chemical carcinogenesis_Homo sapiens_hsa052041.53187325
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.51073949
52Carbon metabolism_Homo sapiens_hsa012001.48923107
53Influenza A_Homo sapiens_hsa051641.46846347
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46161842
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44971315
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.40603559
57B cell receptor signaling pathway_Homo sapiens_hsa046621.40283527
58Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39339933
59Caffeine metabolism_Homo sapiens_hsa002321.37390930
60Toxoplasmosis_Homo sapiens_hsa051451.37281785
61Starch and sucrose metabolism_Homo sapiens_hsa005001.37084003
62Measles_Homo sapiens_hsa051621.34850445
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.33549214
64Chemokine signaling pathway_Homo sapiens_hsa040621.33244403
65Jak-STAT signaling pathway_Homo sapiens_hsa046301.32230640
66Fatty acid elongation_Homo sapiens_hsa000621.30253773
67Selenocompound metabolism_Homo sapiens_hsa004501.29129067
68Phenylalanine metabolism_Homo sapiens_hsa003601.28367639
69Retinol metabolism_Homo sapiens_hsa008301.27540723
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25262130
71Drug metabolism - other enzymes_Homo sapiens_hsa009831.25090717
72Phagosome_Homo sapiens_hsa041451.21728367
73Staphylococcus aureus infection_Homo sapiens_hsa051501.20612063
74Biosynthesis of amino acids_Homo sapiens_hsa012301.20026517
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19701482
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19248420
77Folate biosynthesis_Homo sapiens_hsa007901.17736646
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14920838
79Salmonella infection_Homo sapiens_hsa051321.13408115
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10214142
81Arginine and proline metabolism_Homo sapiens_hsa003301.10118490
82Cysteine and methionine metabolism_Homo sapiens_hsa002701.09183399
83Fat digestion and absorption_Homo sapiens_hsa049751.07791981
84Herpes simplex infection_Homo sapiens_hsa051681.06683263
85Glutathione metabolism_Homo sapiens_hsa004801.04521619
86Antigen processing and presentation_Homo sapiens_hsa046121.04208841
87Lysine degradation_Homo sapiens_hsa003100.99768712
88Tyrosine metabolism_Homo sapiens_hsa003500.98790362
89ABC transporters_Homo sapiens_hsa020100.96191173
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93358149
91Hepatitis B_Homo sapiens_hsa051610.92420016
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87717902
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86482421
94Acute myeloid leukemia_Homo sapiens_hsa052210.85325565
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81939163
96T cell receptor signaling pathway_Homo sapiens_hsa046600.80710250
97Steroid biosynthesis_Homo sapiens_hsa001000.80643248
98Fatty acid biosynthesis_Homo sapiens_hsa000610.79055989
99* Glycerolipid metabolism_Homo sapiens_hsa005610.78852548
100Prolactin signaling pathway_Homo sapiens_hsa049170.76977617
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75985202
102Platelet activation_Homo sapiens_hsa046110.75344754
103Amoebiasis_Homo sapiens_hsa051460.72774865
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72602650
105Viral myocarditis_Homo sapiens_hsa054160.72167204
106Sulfur relay system_Homo sapiens_hsa041220.71539018
107Apoptosis_Homo sapiens_hsa042100.71222588
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69202750
109Shigellosis_Homo sapiens_hsa051310.68510814
110Primary immunodeficiency_Homo sapiens_hsa053400.65905401
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.63304472
112Pentose phosphate pathway_Homo sapiens_hsa000300.63158459
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.62072397
114Fructose and mannose metabolism_Homo sapiens_hsa000510.60976535
115Non-small cell lung cancer_Homo sapiens_hsa052230.60029116
116Sphingolipid metabolism_Homo sapiens_hsa006000.59591514
117Mineral absorption_Homo sapiens_hsa049780.58582133
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57223949
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55309711
120Pancreatic cancer_Homo sapiens_hsa052120.52633032
121* Metabolic pathways_Homo sapiens_hsa011000.49992197
122Galactose metabolism_Homo sapiens_hsa000520.46947093
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46352645
124Renin-angiotensin system_Homo sapiens_hsa046140.45918014
125VEGF signaling pathway_Homo sapiens_hsa043700.45061689
126HIF-1 signaling pathway_Homo sapiens_hsa040660.44293915
127Vitamin B6 metabolism_Homo sapiens_hsa007500.40978005
128FoxO signaling pathway_Homo sapiens_hsa040680.39941972
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37994807
130Bladder cancer_Homo sapiens_hsa052190.37551324
131Chronic myeloid leukemia_Homo sapiens_hsa052200.37548839
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36053241
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.31363497
134One carbon pool by folate_Homo sapiens_hsa006700.30624164
135Collecting duct acid secretion_Homo sapiens_hsa049660.29351560
136Protein digestion and absorption_Homo sapiens_hsa049740.25775883
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23944014
138Insulin resistance_Homo sapiens_hsa049310.23557261
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22056950
140Other glycan degradation_Homo sapiens_hsa005110.14561273
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.11865771
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10293057
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.09761636
144Lysosome_Homo sapiens_hsa041420.07656728
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07613652
146Glucagon signaling pathway_Homo sapiens_hsa049220.05379162
147Thyroid hormone synthesis_Homo sapiens_hsa049180.03983732
148AMPK signaling pathway_Homo sapiens_hsa041520.03422328
149Prion diseases_Homo sapiens_hsa050200.03198866
150Arachidonic acid metabolism_Homo sapiens_hsa005900.02140658
151Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.01495391
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.01381208
153Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1419970
154Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1394349
155Insulin signaling pathway_Homo sapiens_hsa04910-0.1378480
156African trypanosomiasis_Homo sapiens_hsa05143-0.1345533
157Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1266764
158Hepatitis C_Homo sapiens_hsa05160-0.0545593
159Oxidative phosphorylation_Homo sapiens_hsa00190-0.0286707
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0206715
161Linoleic acid metabolism_Homo sapiens_hsa00591-0.0176980

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