GJB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.73284291
2hair cycle (GO:0042633)8.17861116
3molting cycle (GO:0042303)8.17861116
4sphingoid metabolic process (GO:0046519)7.32038003
5keratinocyte differentiation (GO:0030216)7.13732529
6keratinocyte proliferation (GO:0043616)7.06804882
7multicellular organismal water homeostasis (GO:0050891)6.98923231
8hemidesmosome assembly (GO:0031581)6.42840212
9sphingosine metabolic process (GO:0006670)6.31723070
10peptide cross-linking (GO:0018149)6.06417878
11cell-substrate junction assembly (GO:0007044)5.93714767
12water homeostasis (GO:0030104)5.93209193
13diol metabolic process (GO:0034311)5.83042581
14skin morphogenesis (GO:0043589)5.63068051
15intermediate filament organization (GO:0045109)5.58684072
16bundle of His cell to Purkinje myocyte communication (GO:0086069)5.52400722
17epidermal cell differentiation (GO:0009913)5.52076490
18long-chain fatty acid biosynthetic process (GO:0042759)5.50261593
19interferon-gamma secretion (GO:0072643)5.13010694
20epidermis development (GO:0008544)5.08138188
21regulation of chemokine secretion (GO:0090196)4.85734883
22establishment of planar polarity (GO:0001736)4.84712445
23establishment of tissue polarity (GO:0007164)4.84712445
24regulation of keratinocyte proliferation (GO:0010837)4.69888003
25glucosamine-containing compound catabolic process (GO:1901072)4.56508377
26fatty acid elongation (GO:0030497)4.46104524
27regulation of phospholipase A2 activity (GO:0032429)4.36150401
28positive regulation of interleukin-8 secretion (GO:2000484)4.34527894
29surfactant homeostasis (GO:0043129)4.31822948
30regulation of ruffle assembly (GO:1900027)4.28414405
31gap junction assembly (GO:0016264)4.26273214
32keratinocyte development (GO:0003334)4.23138634
33regulation of glomerular filtration (GO:0003093)4.17605792
34negative regulation of keratinocyte proliferation (GO:0010839)4.16985325
35negative regulation of chondrocyte differentiation (GO:0032331)4.08896002
36detection of bacterium (GO:0016045)4.05352274
37hypotonic response (GO:0006971)4.02678937
38polarized epithelial cell differentiation (GO:0030859)3.94967885
39cyclooxygenase pathway (GO:0019371)3.93980330
40linoleic acid metabolic process (GO:0043651)3.90400757
41regulation of integrin-mediated signaling pathway (GO:2001044)3.80942406
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.80609472
43atrioventricular valve morphogenesis (GO:0003181)3.77754105
44regulation of keratinocyte differentiation (GO:0045616)3.76426261
45lateral sprouting from an epithelium (GO:0060601)3.75211400
46viral transcription (GO:0019083)3.71718190
47positive regulation of chemokine secretion (GO:0090197)3.68118228
48regulation of transforming growth factor beta1 production (GO:0032908)3.66040677
49positive regulation of keratinocyte differentiation (GO:0045618)3.64964913
50regulation of interleukin-8 secretion (GO:2000482)3.64705507
51lipoxygenase pathway (GO:0019372)3.61591455
52ribosomal small subunit biogenesis (GO:0042274)3.58390617
53ectoderm development (GO:0007398)3.57564800
54regulation of cell proliferation involved in kidney development (GO:1901722)3.55016739
55diterpenoid biosynthetic process (GO:0016102)3.54626849
56translational termination (GO:0006415)3.50349930
57regulation of epidermis development (GO:0045682)3.49906479
58regulation of transforming growth factor beta2 production (GO:0032909)3.47315612
59positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.43854405
60detection of other organism (GO:0098543)3.40176394
61ventricular cardiac muscle cell action potential (GO:0086005)3.38525123
62renal system process involved in regulation of blood volume (GO:0001977)3.37455633
63prostanoid biosynthetic process (GO:0046457)3.33982564
64prostaglandin biosynthetic process (GO:0001516)3.33982564
65mesodermal cell differentiation (GO:0048333)3.28151058
66intermediate filament cytoskeleton organization (GO:0045104)3.27427436
67regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.26545554
68notochord development (GO:0030903)3.21724630
69negative regulation of stress fiber assembly (GO:0051497)3.21404931
70regulation of epidermal cell differentiation (GO:0045604)3.20908022
71wound healing, spreading of epidermal cells (GO:0035313)3.20350670
72epithelium development (GO:0060429)3.19903209
73limb bud formation (GO:0060174)3.18697459
74negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.17043238
75intermediate filament-based process (GO:0045103)3.16598112
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.16531742
77epithelial cell-cell adhesion (GO:0090136)3.13555703
78membrane budding (GO:0006900)3.12918991
79eyelid development in camera-type eye (GO:0061029)3.12750932
80gland morphogenesis (GO:0022612)3.11602659
81positive regulation of hair cycle (GO:0042635)3.11599938
82positive regulation of hair follicle development (GO:0051798)3.11599938
83long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.08628345
84positive regulation of epidermis development (GO:0045684)3.07859574
85maturation of SSU-rRNA (GO:0030490)3.06082419
86regulation of cardioblast differentiation (GO:0051890)3.05990403
87negative regulation of cartilage development (GO:0061037)3.05219197
88positive regulation of actin filament depolymerization (GO:0030836)3.05170262
89dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.02790509
90primary alcohol catabolic process (GO:0034310)3.01706812
91retinol metabolic process (GO:0042572)3.00302538
92retinal metabolic process (GO:0042574)2.99908850
93SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.99454747
94negative regulation of cell fate specification (GO:0009996)2.99056615
95cell junction organization (GO:0034330)2.99003077
96phosphatidylinositol acyl-chain remodeling (GO:0036149)2.98167450
97negative regulation of interferon-gamma production (GO:0032689)2.97519474
98phosphatidylserine acyl-chain remodeling (GO:0036150)2.97287310
99chemical homeostasis within a tissue (GO:0048875)2.97126885
100hair follicle morphogenesis (GO:0031069)2.96574290
101planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96209712
102cell junction assembly (GO:0034329)2.95698635
103axonemal dynein complex assembly (GO:0070286)2.95538712
104protein targeting to ER (GO:0045047)2.95213624
105regulation of hair cycle (GO:0042634)2.94278872
106cell adhesion mediated by integrin (GO:0033627)2.94229555
107phospholipid scrambling (GO:0017121)2.94093482
108cotranslational protein targeting to membrane (GO:0006613)2.91601917
109morphogenesis of embryonic epithelium (GO:0016331)2.91397876
110positive regulation of vesicle fusion (GO:0031340)2.90399617
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.90091816
112translational elongation (GO:0006414)2.87713457
113prostanoid metabolic process (GO:0006692)2.86646704
114prostaglandin metabolic process (GO:0006693)2.86646704
115establishment of protein localization to endoplasmic reticulum (GO:0072599)2.86017203
116protein localization to endosome (GO:0036010)2.85700571
117wound healing, spreading of cells (GO:0044319)2.84663677
118viral life cycle (GO:0019058)2.83973860
119intestinal epithelial cell development (GO:0060576)2.82344942
120regulation of heart rate by cardiac conduction (GO:0086091)2.80867483
121tight junction assembly (GO:0070830)2.80628672
122skin development (GO:0043588)2.79636240
123adhesion of symbiont to host cell (GO:0044650)2.79361382
124virion attachment to host cell (GO:0019062)2.79361382
125mitotic G1 DNA damage checkpoint (GO:0031571)2.78258599
126regulation of hair follicle development (GO:0051797)2.77831596
127negative regulation of epidermis development (GO:0045683)2.77607251
128amino sugar catabolic process (GO:0046348)2.76924377
129protein localization to endoplasmic reticulum (GO:0070972)2.75241746
130G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.72487760
131negative regulation of stem cell proliferation (GO:2000647)2.71893458
132cellular protein complex disassembly (GO:0043624)2.71641159
133hair cycle process (GO:0022405)2.69745041
134molting cycle process (GO:0022404)2.69745041
135ceramide catabolic process (GO:0046514)2.64333622
136positive regulation of Cdc42 GTPase activity (GO:0043089)2.62925413
137positive regulation of glomerulus development (GO:0090193)2.61879374
138positive regulation of epidermal cell differentiation (GO:0045606)2.61136487
139heart valve morphogenesis (GO:0003179)2.60880904
140cell-cell junction assembly (GO:0007043)2.60649091
141endosome organization (GO:0007032)2.58474296
142renal filtration (GO:0097205)2.57605301
143fusion of sperm to egg plasma membrane (GO:0007342)2.57331297
144mitotic G1/S transition checkpoint (GO:0044819)2.55921270
145filopodium assembly (GO:0046847)2.55297431
146terpenoid biosynthetic process (GO:0016114)2.51388274
147cell communication involved in cardiac conduction (GO:0086065)2.51203828
148one-carbon compound transport (GO:0019755)2.50344150
149cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.48692126
150regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.48663707
151regulation of metalloenzyme activity (GO:0048552)2.48499042
152wound healing (GO:0042060)2.46053954
153desmosome organization (GO:0002934)14.2708375
154establishment of skin barrier (GO:0061436)10.8757150
155regulation of water loss via skin (GO:0033561)10.2682400

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.02622337
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.56294928
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.19134040
4* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.95879065
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.71785585
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.55181457
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.52246777
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.52246777
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.38686481
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.37374716
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.20099944
12TP63_17297297_ChIP-ChIP_HaCaT_Human15.9403600
13HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95959135
14FOXO3_23340844_ChIP-Seq_DLD1_Human1.89225588
15ZNF263_19887448_ChIP-Seq_K562_Human1.78369197
16SOX2_20726797_ChIP-Seq_SW620_Human1.67596270
17CJUN_26792858_Chip-Seq_BT549_Human1.53919820
18* ATF3_27146783_Chip-Seq_COLON_Human1.53569585
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50405918
20* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47468109
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.46382394
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43731790
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40410669
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36734355
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35531508
26RACK7_27058665_Chip-Seq_MCF-7_Human1.33158371
27GATA3_24758297_ChIP-Seq_MCF-7_Human1.31462059
28GATA4_25053715_ChIP-Seq_YYC3_Human1.30990630
29TP63_23658742_ChIP-Seq_EP156T_Human1.28351546
30KLF5_25053715_ChIP-Seq_YYC3_Human1.28320206
31RUNX1_27514584_Chip-Seq_MCF-7_Human1.26638965
32* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26636626
33TCF4_18268006_ChIP-ChIP_LS174T_Human1.25583853
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24125377
35* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21738952
36JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19054123
37* TP63_22573176_ChIP-Seq_HFKS_Human1.16805452
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15792687
39ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12634394
40JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12536451
41CDX2_20551321_ChIP-Seq_CACO-2_Human1.11831702
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.09767529
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.08740577
44TP53_18474530_ChIP-ChIP_U2OS_Human1.08432977
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.07962009
46* CTCF_27219007_Chip-Seq_Bcells_Human1.06870097
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05800417
48* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05581748
49BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05351862
50SMC4_20622854_ChIP-Seq_HELA_Human1.04238272
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04076810
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03908904
53* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01090891
54FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99706778
55GATA6_25053715_ChIP-Seq_YYC3_Human0.99473750
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98631834
57* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98584158
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97813910
59* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96505452
60ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95620650
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95178672
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95029515
63FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94807995
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93674409
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93230871
66RXR_22108803_ChIP-Seq_LS180_Human0.92201417
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.92187374
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92029538
69SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90611215
70* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89453731
71CLOCK_20551151_ChIP-Seq_293T_Human0.87116894
72* SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87106726
73* BCOR_27268052_Chip-Seq_Bcells_Human0.86874091
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84753230
75* P68_20966046_ChIP-Seq_HELA_Human0.81094639
76GATA2_21666600_ChIP-Seq_HMVEC_Human0.79899449
77CSB_26484114_Chip-Seq_FIBROBLAST_Human0.79546689
78* GATA6_21074721_ChIP-Seq_CACO-2_Human0.79251130
79LXR_22292898_ChIP-Seq_THP-1_Human0.78586955
80CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78146536
81TP53_22127205_ChIP-Seq_IMR90_Human0.77970835
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.77361379
83* E2F1_20622854_ChIP-Seq_HELA_Human0.76897296
84* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.75738985
85AHR_22903824_ChIP-Seq_MCF-7_Human0.75191813
86P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.74658151
87P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74436152
88ELK3_25401928_ChIP-Seq_HUVEC_Human0.73165353
89* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.72519221
90GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.71787757
91ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71182364
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.70976517
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70492070
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69684822
95SA1_27219007_Chip-Seq_ERYTHROID_Human0.69070494
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68988510
97ESR1_20079471_ChIP-ChIP_T-47D_Human0.68486951
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.68481710
99* CTCF_20526341_ChIP-Seq_ESCs_Human0.68306023
100AR_21572438_ChIP-Seq_LNCaP_Human0.68118898
101* TET1_21490601_ChIP-Seq_MESCs_Mouse0.67713737
102KDM2B_26808549_Chip-Seq_K562_Human0.67482583
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66807268
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.66375802
105ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.65785402
106CEBPB_22108803_ChIP-Seq_LS180_Human0.65564483
107PPARA_22158963_ChIP-Seq_LIVER_Mouse0.63820829
108NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63297206
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63297206
110TP53_16413492_ChIP-PET_HCT116_Human0.63259320
111EGR1_19032775_ChIP-ChIP_M12_Human0.63012304
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.62896244
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.61899337
114* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.61287716
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60491804
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.60413497
117SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.58623109
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.58257982
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.57187602
120BRD4_25478319_ChIP-Seq_HGPS_Human0.55795697
121TCF4_22108803_ChIP-Seq_LS180_Human0.53983717
122* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.53975596
123SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.53299672
124TBX20_22080862_ChIP-Seq_HEART_Mouse0.52956943
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.52956943

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.76099412
2MP0003941_abnormal_skin_development5.60063325
3MP0005275_abnormal_skin_tensile5.18287652
4MP0005501_abnormal_skin_physiology4.56797718
5MP0010234_abnormal_vibrissa_follicle4.24959447
6MP0000579_abnormal_nail_morphology3.66456294
7MP0001216_abnormal_epidermal_layer3.26396303
8MP0002060_abnormal_skin_morphology3.23232302
9MP0003705_abnormal_hypodermis_morpholog3.18533162
10MP0004381_abnormal_hair_follicle3.17249292
11MP0002098_abnormal_vibrissa_morphology3.04988489
12MP0003453_abnormal_keratinocyte_physiol3.03564713
13MP0010771_integument_phenotype2.78727463
14MP0000647_abnormal_sebaceous_gland2.65784681
15MP0002254_reproductive_system_inflammat2.64166202
16MP0000383_abnormal_hair_follicle2.56462884
17MP0003566_abnormal_cell_adhesion2.54111141
18MP0010678_abnormal_skin_adnexa2.41308166
19MP0000377_abnormal_hair_follicle2.39589596
20MP0000762_abnormal_tongue_morphology2.24958127
21MP0000467_abnormal_esophagus_morphology2.24880918
22MP0000566_synostosis2.19666953
23MP0005409_darkened_coat_color2.18457358
24MP0004947_skin_inflammation2.09840480
25MP0005451_abnormal_body_composition2.06008494
26MP0000427_abnormal_hair_cycle2.01189440
27MP0010352_gastrointestinal_tract_polyps1.65477502
28MP0001243_abnormal_dermal_layer1.63458745
29MP0005023_abnormal_wound_healing1.63076569
30MP0001191_abnormal_skin_condition1.61849286
31MP0003950_abnormal_plasma_membrane1.57106994
32MP0004185_abnormal_adipocyte_glucose1.56757389
33MP0009931_abnormal_skin_appearance1.55466141
34MP0001346_abnormal_lacrimal_gland1.48636538
35MP0003011_delayed_dark_adaptation1.46290062
36MP0009384_cardiac_valve_regurgitation1.43140147
37MP0002282_abnormal_trachea_morphology1.38354542
38MP0000367_abnormal_coat/_hair1.32805741
39MP0009379_abnormal_foot_pigmentation1.32641940
40MP0001542_abnormal_bone_strength1.30371377
41MP0009053_abnormal_anal_canal1.29112638
42MP0003300_gastrointestinal_ulcer1.27716546
43MP0008004_abnormal_stomach_pH1.24096683
44MP0000678_abnormal_parathyroid_gland1.23886605
45MP0009780_abnormal_chondrocyte_physiolo1.23388027
46MP0000537_abnormal_urethra_morphology1.19921851
47MP0010030_abnormal_orbit_morphology1.18903231
48MP0003315_abnormal_perineum_morphology1.15383613
49MP0002877_abnormal_melanocyte_morpholog1.06533291
50MP0005508_abnormal_skeleton_morphology1.05909410
51MP0000627_abnormal_mammary_gland1.04157233
52MP0004272_abnormal_basement_membrane1.04026066
53MP0008438_abnormal_cutaneous_collagen1.00898225
54MP0009250_abnormal_appendicular_skeleto0.99684843
55MP0000516_abnormal_urinary_system0.99249184
56MP0005367_renal/urinary_system_phenotyp0.99249184
57MP0002234_abnormal_pharynx_morphology0.98847765
58MP0003755_abnormal_palate_morphology0.98285631
59MP0002095_abnormal_skin_pigmentation0.97564960
60MP0001188_hyperpigmentation0.96184291
61MP0005248_abnormal_Harderian_gland0.91647013
62MP0001340_abnormal_eyelid_morphology0.91575923
63MP0002933_joint_inflammation0.91246084
64MP0002009_preneoplasia0.89655543
65MP0003878_abnormal_ear_physiology0.88794694
66MP0005377_hearing/vestibular/ear_phenot0.88794694
67MP0005083_abnormal_biliary_tract0.86258668
68MP0001958_emphysema0.82671627
69MP0001851_eye_inflammation0.80664888
70MP0000163_abnormal_cartilage_morphology0.79655399
71MP0002111_abnormal_tail_morphology0.78784814
72MP0006054_spinal_hemorrhage0.77443932
73MP0004885_abnormal_endolymph0.77201623
74MP0000465_gastrointestinal_hemorrhage0.76537838
75MP0008789_abnormal_olfactory_epithelium0.74470505
76MP0008260_abnormal_autophagy0.71600983
77MP0005390_skeleton_phenotype0.70530044
78MP0005410_abnormal_fertilization0.68881872
79MP0003436_decreased_susceptibility_to0.67542002
80MP0001849_ear_inflammation0.65894814
81MP0004264_abnormal_extraembryonic_tissu0.65657145
82MP0003091_abnormal_cell_migration0.65322642
83MP0002177_abnormal_outer_ear0.62424099
84MP0005076_abnormal_cell_differentiation0.61924669
85MP0003806_abnormal_nucleotide_metabolis0.57234497
86MP0002896_abnormal_bone_mineralization0.57062057
87MP0002115_abnormal_skeleton_extremities0.55776738
88MP0002233_abnormal_nose_morphology0.55581725
89MP0003385_abnormal_body_wall0.54984992
90MP0000432_abnormal_head_morphology0.54950599
91MP0003191_abnormal_cellular_cholesterol0.54452500
92MP0003718_maternal_effect0.54402672
93MP0005394_taste/olfaction_phenotype0.54251578
94MP0005499_abnormal_olfactory_system0.54251578
95MP0002249_abnormal_larynx_morphology0.53222718
96MP0005623_abnormal_meninges_morphology0.53167613
97MP0003123_paternal_imprinting0.52029953
98MP0001533_abnormal_skeleton_physiology0.51191972
99MP0000613_abnormal_salivary_gland0.50153432
100MP0009840_abnormal_foam_cell0.50082312
101MP0002109_abnormal_limb_morphology0.50077139
102MP0001784_abnormal_fluid_regulation0.49826348
103MP0005503_abnormal_tendon_morphology0.49313997
104MP0003638_abnormal_response/metabolism_0.49081354
105MP0004197_abnormal_fetal_growth/weight/0.49055561
106MP0001299_abnormal_eye_distance/0.48966108
107MP0003936_abnormal_reproductive_system0.48760168
108MP0000015_abnormal_ear_pigmentation0.47620823
109MP0000750_abnormal_muscle_regeneration0.47416718
110MP0004134_abnormal_chest_morphology0.44835260
111MP0001765_abnormal_ion_homeostasis0.44208370
112MP0002295_abnormal_pulmonary_circulatio0.43974610
113MP0002089_abnormal_postnatal_growth/wei0.43349455
114MP0000858_altered_metastatic_potential0.41961062
115MP0002113_abnormal_skeleton_development0.40845019
116MP0004782_abnormal_surfactant_physiolog0.40518113
117MP0000538_abnormal_urinary_bladder0.40503835
118MP0004019_abnormal_vitamin_homeostasis0.39931132
119MP0003795_abnormal_bone_structure0.39624353
120MP0005666_abnormal_adipose_tissue0.39309349
121MP0001286_abnormal_eye_development0.38879859
122MP0003045_fibrosis0.38382062
123MP0005197_abnormal_uvea_morphology0.38116983
124MP0010368_abnormal_lymphatic_system0.35626897
125MP0000470_abnormal_stomach_morphology0.35003611
126MP0006138_congestive_heart_failure0.34986152
127MP0005075_abnormal_melanosome_morpholog0.34398636
128MP0001348_abnormal_lacrimal_gland0.33620423
129MP0005193_abnormal_anterior_eye0.33589401
130MP0005257_abnormal_intraocular_pressure0.33161781
131MP0010155_abnormal_intestine_physiology0.32873579
132MP0005164_abnormal_response_to0.32199397
133MP0005375_adipose_tissue_phenotype0.29510498
134MP0003329_amyloid_beta_deposits0.29116939
135MP0003763_abnormal_thymus_physiology0.28517790
136MP0005166_decreased_susceptibility_to0.27746949
137MP0005174_abnormal_tail_pigmentation0.26093107

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)5.79659969
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.70961292
3Congenital ichthyosiform erythroderma (HP:0007431)5.69562623
4Right ventricular cardiomyopathy (HP:0011663)5.48576560
5Woolly hair (HP:0002224)5.38448999
6Abnormality of nail color (HP:0100643)5.34496600
7Plantar hyperkeratosis (HP:0007556)5.10517065
8Palmoplantar hyperkeratosis (HP:0000972)4.84367761
9Parakeratosis (HP:0001036)4.74408225
10Palmar hyperkeratosis (HP:0010765)4.54333606
11Fragile nails (HP:0001808)4.39806178
12Onycholysis (HP:0001806)4.15914328
13Natal tooth (HP:0000695)3.97088621
14Lip pit (HP:0100267)3.94394767
15Epiphyseal dysplasia (HP:0002656)3.92508745
16Increased IgE level (HP:0003212)3.91269970
17Erythroderma (HP:0001019)3.72066170
18* Erythema (HP:0010783)3.67226021
19Irregular epiphyses (HP:0010582)3.58573848
20Nail dystrophy (HP:0008404)3.52534951
21Milia (HP:0001056)3.41428490
22Oral leukoplakia (HP:0002745)3.41119698
23Distal lower limb muscle weakness (HP:0009053)3.40900517
24Hypoplasia of dental enamel (HP:0006297)3.38371443
25Pili torti (HP:0003777)3.29446060
26Vitreoretinal degeneration (HP:0000655)3.24230723
27* Abnormal blistering of the skin (HP:0008066)3.17046157
28Advanced eruption of teeth (HP:0006288)3.16167469
29Conjunctival hamartoma (HP:0100780)3.15152204
30Cupped ribs (HP:0000887)3.11308807
31Atrophic scars (HP:0001075)3.07354382
32Severe Myopia (HP:0011003)3.05235157
33Absent eyelashes (HP:0000561)3.00784891
34Sparse eyelashes (HP:0000653)3.00758153
35Corneal erosion (HP:0200020)2.99414420
36Hypohidrosis (HP:0000966)2.97550111
37Selective tooth agenesis (HP:0001592)2.96896598
38Ectropion (HP:0000656)2.96461293
39Popliteal pterygium (HP:0009756)2.91844509
40Pterygium (HP:0001059)2.85874220
41Abnormality of secondary sexual hair (HP:0009888)2.82848176
42Abnormality of the axillary hair (HP:0100134)2.82848176
43Sparse scalp hair (HP:0002209)2.79877772
44Abnormality of placental membranes (HP:0011409)2.76381751
45Amniotic constriction ring (HP:0009775)2.76381751
46Flat acetabular roof (HP:0003180)2.75624070
47Abnormal tarsal ossification (HP:0008369)2.73799097
48Abnormality of the neuromuscular junction (HP:0003398)2.67505122
49Fatigable weakness (HP:0003473)2.67505122
50Neonatal short-limb short stature (HP:0008921)2.63385173
51Oligodontia (HP:0000677)2.61424047
52Curly hair (HP:0002212)2.61202652
53Ventricular tachycardia (HP:0004756)2.57471125
54Thick nail (HP:0001805)2.49672561
55Alopecia of scalp (HP:0002293)2.49656774
56Gangrene (HP:0100758)2.47166985
57Hypoplastic ischia (HP:0003175)2.44670136
58Abnormality of the distal phalanges of the toes (HP:0010182)2.40787913
59Acanthosis nigricans (HP:0000956)2.38139547
60* Palmoplantar keratoderma (HP:0000982)2.35650063
61Premature rupture of membranes (HP:0001788)2.34690816
62Abnormality of the dental root (HP:0006486)2.33238462
63Taurodontia (HP:0000679)2.33238462
64Abnormality of permanent molar morphology (HP:0011071)2.33238462
65Blepharitis (HP:0000498)2.33158062
66Hyporeflexia of lower limbs (HP:0002600)2.32136347
67Ankyloglossia (HP:0010296)2.31484270
68Down-sloping shoulders (HP:0200021)2.30138964
69Hyperhidrosis (HP:0000975)2.25365540
70Congenital, generalized hypertrichosis (HP:0004540)2.22166516
71Genu varum (HP:0002970)2.18482346
72Concave nail (HP:0001598)2.16583191
73Brittle hair (HP:0002299)2.15359697
74Trismus (HP:0000211)2.14312296
75Abnormality of molar morphology (HP:0011070)2.13917572
76Abnormality of molar (HP:0011077)2.13917572
77Dehydration (HP:0001944)2.13906333
78Abnormality of the salivary glands (HP:0010286)2.13864060
79Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.12259297
80Small epiphyses (HP:0010585)2.12018868
81Pruritus (HP:0000989)2.09078489
82Hypoplastic labia majora (HP:0000059)2.08727949
83Xerostomia (HP:0000217)2.08639433
84Upper limb muscle weakness (HP:0003484)2.08062112
85Abnormality of the ischium (HP:0003174)2.07718761
86Abnormality of the dental pulp (HP:0006479)2.06203932
87Carious teeth (HP:0000670)2.05809127
88Abnormal foot bone ossification (HP:0010675)2.04044783
89Hypodontia (HP:0000668)2.02216813
90Abnormal hair laboratory examination (HP:0003328)2.01444068
91Amelogenesis imperfecta (HP:0000705)2.01005348
92Metaphyseal dysplasia (HP:0100255)2.00624400
93Aplasia involving bones of the upper limbs (HP:0009823)1.99588518
94Aplasia of the phalanges of the hand (HP:0009802)1.99588518
95Aplasia involving bones of the extremities (HP:0009825)1.99588518
96Protrusio acetabuli (HP:0003179)1.99193237
97Chronic bronchitis (HP:0004469)1.98956219
98Slow-growing hair (HP:0002217)1.97783002
99Abnormality of hair growth rate (HP:0011363)1.97783002
100Follicular hyperkeratosis (HP:0007502)1.97267981
101Flat capital femoral epiphysis (HP:0003370)1.96972305
102Coxa vara (HP:0002812)1.93846038
103Multifactorial inheritance (HP:0001426)1.93131100
104Nasolacrimal duct obstruction (HP:0000579)1.91774695
105Anonychia (HP:0001798)1.91463916
106Breast hypoplasia (HP:0003187)1.90493537
107Aplasia cutis congenita (HP:0001057)1.89098725
108Abnormal vertebral ossification (HP:0100569)1.88655846
109Increased connective tissue (HP:0009025)1.87437776
110Abnormality of the labia majora (HP:0012881)1.86756280
111Fragile skin (HP:0001030)1.86573904
112Absent hair (HP:0002298)1.85921436
113Abnormality of the fingernails (HP:0001231)1.84397219
114Metaphyseal cupping (HP:0003021)1.83986037
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83934166
116Abnormality of the gastric mucosa (HP:0004295)1.83710350
117Abnormality of the 2nd finger (HP:0004100)1.82775677
118Laryngomalacia (HP:0001601)1.82739187
119Skin ulcer (HP:0200042)1.82710561
120Focal segmental glomerulosclerosis (HP:0000097)1.81322674
121Glossoptosis (HP:0000162)1.79408812
122Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76340751
123Vertebral hypoplasia (HP:0008417)1.76340751
124Split foot (HP:0001839)1.76004276
125Recurrent corneal erosions (HP:0000495)1.75595311
126Abnormal hemoglobin (HP:0011902)1.73640235
127Neonatal death (HP:0003811)1.71745535
128Hypoplasia of the uterus (HP:0000013)1.71389291
129Septate vagina (HP:0001153)1.70564313
130Nasal polyposis (HP:0100582)1.70509429
131Stenosis of the external auditory canal (HP:0000402)1.70353284
132Cheilitis (HP:0100825)1.70107437
133Hyperactive renin-angiotensin system (HP:0000841)1.70032239
134Axonal loss (HP:0003447)1.69988905
135Abnormality of oral frenula (HP:0000190)1.69657192
136Stillbirth (HP:0003826)1.68877735
137Hamartoma of the eye (HP:0010568)1.68189864
138Hypoplastic scapulae (HP:0000882)1.68005073
139Aplasia/Hypoplasia of the scapulae (HP:0006713)1.68005073
140Osteoarthritis (HP:0002758)1.67046205
141Ridged nail (HP:0001807)1.66177383
142Labial hypoplasia (HP:0000066)1.66039136
143Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.63096824
144Corneal dystrophy (HP:0001131)1.62612742
145Areflexia of lower limbs (HP:0002522)1.62202611
146Hypoplastic pelvis (HP:0008839)1.61642726
147Dry hair (HP:0011359)1.60466977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K35.46336645
2EPHA24.57291164
3MAPKAPK33.79849878
4MST43.50994566
5TESK13.40503375
6MST1R3.40061823
7PIM23.38688600
8FER3.38542825
9LMTK22.70529500
10EPHB22.69767673
11RPS6KB22.63900140
12LIMK12.53109811
13MAP3K92.51647810
14TAOK12.49363786
15TRPM72.24881974
16TAOK22.16064766
17ARAF2.07478553
18MAP3K111.95899159
19STK101.91353203
20SIK11.87747874
21LATS11.76860804
22ERN11.69198387
23MET1.64215373
24MAP3K21.60415549
25STK241.60229211
26SMG11.60062769
27DDR21.54729503
28ERBB31.51347133
29LRRK21.51008717
30MAP3K121.46180202
31MAP2K31.41428347
32LATS21.37121356
33BCR1.33873998
34MAP3K61.33758252
35STK38L1.33228102
36TTN1.19934638
37NME11.15517164
38TRIB31.12898126
39EEF2K1.12352774
40NME21.09707228
41MAPKAPK51.09325377
42MAPK151.08687691
43TGFBR21.08425696
44PTK21.08056387
45DYRK1B1.07613925
46PIK3CG1.07287784
47NTRK11.03079861
48IRAK31.02688180
49FLT30.98644729
50CDK120.95168388
51BLK0.94966492
52RPS6KA40.88798088
53CDK60.82963651
54PTK60.82014138
55MAP2K60.81328098
56STK380.79850869
57PRKCI0.79634091
58MAPKAPK20.79594102
59MYLK0.77877520
60GRK10.76981101
61TNK20.74987654
62MOS0.74248742
63PAK30.72040216
64MAP2K10.67771530
65MAP3K50.65895064
66FGFR10.65195282
67TLK10.62727023
68CDK80.60894760
69MAP3K130.60020115
70PDK20.58292394
71PTK2B0.57376797
72ROCK10.56217367
73NUAK10.55270959
74PINK10.55167349
75ILK0.53540064
76MAP2K20.52652121
77GRK70.49388485
78AURKA0.48815940
79MARK20.47315283
80AURKB0.46652590
81SIK30.44609104
82MAP3K70.44307409
83RPS6KA20.44128148
84PAK20.43928264
85BRD40.41916284
86EPHB10.41231942
87MAP3K10.40784346
88TTK0.40632847
89STK30.39882763
90EIF2AK20.39857435
91MAP3K80.39582495
92CDK90.39060504
93PLK40.38888541
94PBK0.38754681
95BMX0.37392681
96PRKD10.37049042
97PRKD20.36722031
98MTOR0.36048281
99FGFR20.36005663
100SGK2230.35398104
101SGK4940.35398104
102IKBKB0.35314093
103ADRBK10.35151518
104PAK40.35104649
105RIPK10.33912919
106CDK70.33345871
107CDC42BPA0.31915587
108NEK60.30689576
109STK390.30386586
110PRKCE0.30136316
111PKN20.30050046
112ITK0.29935245
113ICK0.28916414
114ABL10.28064942
115DYRK20.26476435
116WNK10.26359850
117FGFR30.26260691
118EPHA30.25513167
119NEK10.25489769
120FGFR40.25403415
121EGFR0.24998885
122GRK50.24288950
123ERBB20.23516872
124PDGFRA0.23210140
125FGR0.23160049
126GSK3A0.21293970
127PDGFRB0.20439625
128ABL20.20380057
129ROCK20.20208902
130PRKG20.20165724
131CSNK1D0.19673978
132SRC0.19133280
133DMPK0.18627282
134PAK10.18552410
135MATK0.17652612
136SGK30.17594111
137BRAF0.17369711
138ERBB40.17205210
139PRKCD0.16401001
140RPS6KA10.16363362
141TGFBR10.16142321
142CSNK1E0.15906136
143KSR20.15796202
144IGF1R0.14936993

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006004.49700041
2Ribosome_Homo sapiens_hsa030103.61750956
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.52495397
4Arachidonic acid metabolism_Homo sapiens_hsa005903.43127168
5ECM-receptor interaction_Homo sapiens_hsa045122.94238371
6Linoleic acid metabolism_Homo sapiens_hsa005912.79268800
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71168845
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.58115732
9Fatty acid elongation_Homo sapiens_hsa000622.33792810
10Adherens junction_Homo sapiens_hsa045202.31571059
11Bladder cancer_Homo sapiens_hsa052192.20014078
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11198449
13Phenylalanine metabolism_Homo sapiens_hsa003602.00557666
14Tight junction_Homo sapiens_hsa045301.93596260
15Hippo signaling pathway_Homo sapiens_hsa043901.88965622
16p53 signaling pathway_Homo sapiens_hsa041151.83194526
17Fatty acid biosynthesis_Homo sapiens_hsa000611.75220554
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.73125475
19Proteasome_Homo sapiens_hsa030501.72774300
20Proteoglycans in cancer_Homo sapiens_hsa052051.72028845
21Ether lipid metabolism_Homo sapiens_hsa005651.70657095
22Histidine metabolism_Homo sapiens_hsa003401.70312116
23Retinol metabolism_Homo sapiens_hsa008301.69902751
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69790383
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66555254
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63557534
27Basal cell carcinoma_Homo sapiens_hsa052171.58532582
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.47837264
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46890895
30Protein digestion and absorption_Homo sapiens_hsa049741.45396792
31Chemical carcinogenesis_Homo sapiens_hsa052041.43387107
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41117028
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31070361
34MicroRNAs in cancer_Homo sapiens_hsa052061.28626012
35Steroid biosynthesis_Homo sapiens_hsa001001.27519344
36TGF-beta signaling pathway_Homo sapiens_hsa043501.25651325
37Glutathione metabolism_Homo sapiens_hsa004801.24713580
38Circadian rhythm_Homo sapiens_hsa047101.24125087
39Notch signaling pathway_Homo sapiens_hsa043301.23201284
40Focal adhesion_Homo sapiens_hsa045101.17399111
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16831800
42Sphingolipid signaling pathway_Homo sapiens_hsa040711.16463045
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09303184
44VEGF signaling pathway_Homo sapiens_hsa043701.06707318
45Axon guidance_Homo sapiens_hsa043601.03915606
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03666980
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02576142
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01687421
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97319288
50Small cell lung cancer_Homo sapiens_hsa052220.96621605
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93805600
52Hedgehog signaling pathway_Homo sapiens_hsa043400.92695267
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91916996
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.89643851
55Tyrosine metabolism_Homo sapiens_hsa003500.88752703
56Inositol phosphate metabolism_Homo sapiens_hsa005620.88154419
57Amoebiasis_Homo sapiens_hsa051460.85852912
58Mineral absorption_Homo sapiens_hsa049780.83528734
59Galactose metabolism_Homo sapiens_hsa000520.81608930
60Thyroid cancer_Homo sapiens_hsa052160.76673652
61Rap1 signaling pathway_Homo sapiens_hsa040150.74959120
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72980677
63Melanoma_Homo sapiens_hsa052180.72031946
64Glycerolipid metabolism_Homo sapiens_hsa005610.71989636
65GnRH signaling pathway_Homo sapiens_hsa049120.71755082
66Shigellosis_Homo sapiens_hsa051310.71229377
67Fructose and mannose metabolism_Homo sapiens_hsa000510.70690604
68Wnt signaling pathway_Homo sapiens_hsa043100.70124533
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69804573
70Vibrio cholerae infection_Homo sapiens_hsa051100.67528526
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66834322
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66827748
73Arginine biosynthesis_Homo sapiens_hsa002200.65870208
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63829263
75Renal cell carcinoma_Homo sapiens_hsa052110.63824325
76Toxoplasmosis_Homo sapiens_hsa051450.63625667
77Caffeine metabolism_Homo sapiens_hsa002320.63288392
78Non-small cell lung cancer_Homo sapiens_hsa052230.63241380
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61004355
80Platelet activation_Homo sapiens_hsa046110.59680160
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58778821
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.58727310
83Insulin signaling pathway_Homo sapiens_hsa049100.58704852
84Renin secretion_Homo sapiens_hsa049240.58612212
85Ras signaling pathway_Homo sapiens_hsa040140.58485776
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.58446484
87Malaria_Homo sapiens_hsa051440.58380465
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57587157
89Pathways in cancer_Homo sapiens_hsa052000.57520313
90Ovarian steroidogenesis_Homo sapiens_hsa049130.56732827
91ErbB signaling pathway_Homo sapiens_hsa040120.56497258
92Apoptosis_Homo sapiens_hsa042100.56264198
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56224005
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54623691
95Hepatitis C_Homo sapiens_hsa051600.54509602
96Melanogenesis_Homo sapiens_hsa049160.51938288
97Influenza A_Homo sapiens_hsa051640.51041631
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50918393
99Choline metabolism in cancer_Homo sapiens_hsa052310.50527048
100Dorso-ventral axis formation_Homo sapiens_hsa043200.48665416
101PPAR signaling pathway_Homo sapiens_hsa033200.48559654
102Endocytosis_Homo sapiens_hsa041440.48001284
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47870384
104Endometrial cancer_Homo sapiens_hsa052130.47718985
105Pertussis_Homo sapiens_hsa051330.47258136
106Salivary secretion_Homo sapiens_hsa049700.47113144
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46850440
108Salmonella infection_Homo sapiens_hsa051320.46338143
109Fat digestion and absorption_Homo sapiens_hsa049750.45830229
110HTLV-I infection_Homo sapiens_hsa051660.45793288
111Phototransduction_Homo sapiens_hsa047440.44820924
112Estrogen signaling pathway_Homo sapiens_hsa049150.43570308
113Staphylococcus aureus infection_Homo sapiens_hsa051500.42593811
114Other glycan degradation_Homo sapiens_hsa005110.39404661
115Arginine and proline metabolism_Homo sapiens_hsa003300.39358925
116Sulfur metabolism_Homo sapiens_hsa009200.38560758
117Gastric acid secretion_Homo sapiens_hsa049710.38069526
118Dilated cardiomyopathy_Homo sapiens_hsa054140.36693841
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34309309
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.33420383
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33320324
122Prostate cancer_Homo sapiens_hsa052150.33291355
123Epstein-Barr virus infection_Homo sapiens_hsa051690.33017054
124Serotonergic synapse_Homo sapiens_hsa047260.32531746
125Acute myeloid leukemia_Homo sapiens_hsa052210.32304406
126Pancreatic secretion_Homo sapiens_hsa049720.32076112
127beta-Alanine metabolism_Homo sapiens_hsa004100.31500283
128TNF signaling pathway_Homo sapiens_hsa046680.29630114
129Phagosome_Homo sapiens_hsa041450.28152322
130Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.27851602
131Glioma_Homo sapiens_hsa052140.27265676
132Vitamin digestion and absorption_Homo sapiens_hsa049770.24994907
133Legionellosis_Homo sapiens_hsa051340.23971126
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23064182
135Pancreatic cancer_Homo sapiens_hsa052120.21332014
136Chronic myeloid leukemia_Homo sapiens_hsa052200.20521058
137Viral carcinogenesis_Homo sapiens_hsa052030.18944625

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