GIPC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.86746826
2hemidesmosome assembly (GO:0031581)5.70788152
3protein localization to endosome (GO:0036010)4.24649588
4cell-substrate junction assembly (GO:0007044)4.22561244
5DNA unwinding involved in DNA replication (GO:0006268)4.11303358
6epithelial cell-cell adhesion (GO:0090136)3.94262091
7adherens junction assembly (GO:0034333)3.91942894
8paraxial mesoderm development (GO:0048339)3.90360100
9DNA strand elongation involved in DNA replication (GO:0006271)3.88364258
10formation of translation preinitiation complex (GO:0001731)3.82717157
11peptidyl-arginine omega-N-methylation (GO:0035247)3.81653594
12focal adhesion assembly (GO:0048041)3.77941699
13cell-substrate adherens junction assembly (GO:0007045)3.77941699
14viral transcription (GO:0019083)3.75999303
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.70402491
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.68474890
17regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.61781985
18translational termination (GO:0006415)3.61723042
19skin morphogenesis (GO:0043589)3.61402685
20regulation of posttranscriptional gene silencing (GO:0060147)3.60988171
21regulation of gene silencing by miRNA (GO:0060964)3.60988171
22regulation of gene silencing by RNA (GO:0060966)3.60988171
23DNA strand elongation (GO:0022616)3.56830182
24regulation of water loss via skin (GO:0033561)3.56695580
25histone arginine methylation (GO:0034969)3.50633921
26semaphorin-plexin signaling pathway (GO:0071526)3.50628600
27basement membrane organization (GO:0071711)3.49796250
28regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49379805
29activation of Rac GTPase activity (GO:0032863)3.48752845
30regulation of translational fidelity (GO:0006450)3.46817177
31maturation of SSU-rRNA (GO:0030490)3.45766998
32translational elongation (GO:0006414)3.45194447
33dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.44823737
34proline biosynthetic process (GO:0006561)3.43606055
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.41264275
36barbed-end actin filament capping (GO:0051016)3.32742219
37translational initiation (GO:0006413)3.28145003
38DNA replication initiation (GO:0006270)3.20807763
39protein maturation by protein folding (GO:0022417)3.19390865
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17945185
41establishment of apical/basal cell polarity (GO:0035089)3.16480192
42regulation of SMAD protein import into nucleus (GO:0060390)3.15344311
43protein insertion into membrane (GO:0051205)3.12731845
44nuclear envelope reassembly (GO:0031468)3.10833602
45mitotic nuclear envelope reassembly (GO:0007084)3.10833602
46regulation of protein heterodimerization activity (GO:0043497)3.10456734
47telomere maintenance via semi-conservative replication (GO:0032201)3.10378127
48positive regulation of Cdc42 GTPase activity (GO:0043089)3.09189344
49amyloid precursor protein catabolic process (GO:0042987)3.06043843
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05953430
51regulation of hippo signaling (GO:0035330)3.05414235
52SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.05027949
53bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04765763
54viral life cycle (GO:0019058)3.02002345
55positive regulation of SMAD protein import into nucleus (GO:0060391)3.01999044
56protein localization to kinetochore (GO:0034501)3.01845122
57establishment or maintenance of monopolar cell polarity (GO:0061339)3.01644556
58establishment of monopolar cell polarity (GO:0061162)3.01644556
59nodal signaling pathway (GO:0038092)3.00299234
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98041192
61cellular protein complex disassembly (GO:0043624)2.97807437
62gap junction assembly (GO:0016264)2.96855959
63polarized epithelial cell differentiation (GO:0030859)2.96698327
64protein targeting to ER (GO:0045047)2.96561007
65peptidyl-arginine methylation (GO:0018216)2.96409079
66peptidyl-arginine N-methylation (GO:0035246)2.96409079
67establishment of skin barrier (GO:0061436)2.96127523
68endothelial cell chemotaxis (GO:0035767)2.94918862
69cotranslational protein targeting to membrane (GO:0006613)2.94405099
70ribosomal small subunit assembly (GO:0000028)2.92936063
71regulation of early endosome to late endosome transport (GO:2000641)2.92689883
72positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.91108739
73vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.88679003
74atrioventricular valve morphogenesis (GO:0003181)2.88611368
75regulation of apoptotic process involved in morphogenesis (GO:1902337)2.86969021
76folic acid-containing compound biosynthetic process (GO:0009396)2.86567805
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.86064355
78DNA replication-dependent nucleosome assembly (GO:0006335)2.84623292
79DNA replication-dependent nucleosome organization (GO:0034723)2.84623292
80GDP-mannose metabolic process (GO:0019673)2.84422191
81branching involved in mammary gland duct morphogenesis (GO:0060444)2.82091627
82ribosomal small subunit biogenesis (GO:0042274)2.81947355
83apoptotic process involved in morphogenesis (GO:0060561)2.80599347
84establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80180734
85protein complex disassembly (GO:0043241)2.80105915
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.79180316
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.77463783
88COPI coating of Golgi vesicle (GO:0048205)2.77317604
89Golgi transport vesicle coating (GO:0048200)2.77317604
90cell adhesion mediated by integrin (GO:0033627)2.77157031
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.76691830
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76138785
93negative regulation of ligase activity (GO:0051352)2.76138785
94multicellular organismal water homeostasis (GO:0050891)2.75553689
95endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.75483994
96IMP biosynthetic process (GO:0006188)2.74917736
97regulation of glucose import in response to insulin stimulus (GO:2001273)2.74016264
98Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73671342
99protein localization to endoplasmic reticulum (GO:0070972)2.73659812
100regulation of translational termination (GO:0006449)2.72518928
101maternal placenta development (GO:0001893)2.72414793
102mitotic G1 DNA damage checkpoint (GO:0031571)2.72195680
103nucleobase-containing small molecule interconversion (GO:0015949)2.72122473
104negative regulation of fatty acid transport (GO:2000192)2.71191032
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70418723
106cell-cell junction maintenance (GO:0045217)2.68186474
107ribosomal large subunit biogenesis (GO:0042273)2.67967727
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.65940859
109endothelial cell morphogenesis (GO:0001886)2.65434995
110heterochromatin organization (GO:0070828)2.65368695
111macromolecular complex disassembly (GO:0032984)2.62469470
112mitotic nuclear envelope disassembly (GO:0007077)2.61892896
113amyloid precursor protein metabolic process (GO:0042982)2.61300203
114lung-associated mesenchyme development (GO:0060484)2.61119277
115vascular endothelial growth factor signaling pathway (GO:0038084)2.60563969
116regulation of cardioblast differentiation (GO:0051890)2.60047049
117negative regulation of chondrocyte differentiation (GO:0032331)2.59204210
118pentose-phosphate shunt (GO:0006098)2.57975877
119positive regulation of keratinocyte differentiation (GO:0045618)2.57950959
120negative regulation of cell size (GO:0045792)2.57675525
121cochlea morphogenesis (GO:0090103)2.56748563
122negative regulation of microtubule polymerization (GO:0031115)2.56593956
123DNA deamination (GO:0045006)2.56142028
124endodermal cell differentiation (GO:0035987)2.55805269
125actin filament bundle organization (GO:0061572)2.55646530
126actin filament bundle assembly (GO:0051017)2.55646530
127protein retention in ER lumen (GO:0006621)2.53610083
128membrane protein ectodomain proteolysis (GO:0006509)2.53323723
129regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53141077
130negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.52954418
131positive regulation of epidermal cell differentiation (GO:0045606)2.52842035
132regulation of establishment of planar polarity (GO:0090175)2.52809255
133positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.51888450
134mammary gland epithelial cell differentiation (GO:0060644)2.51630700
135negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.50969553
136stress fiber assembly (GO:0043149)2.50181840
137regulation of fatty acid beta-oxidation (GO:0031998)2.49153955
138NADPH regeneration (GO:0006740)2.49087752
139telomere maintenance via recombination (GO:0000722)2.48091525
140nuclear envelope disassembly (GO:0051081)2.47844061
141membrane disassembly (GO:0030397)2.47844061
142positive regulation of epidermis development (GO:0045684)2.46944179
143cell junction assembly (GO:0034329)2.45853092
144translation (GO:0006412)2.44847607
145activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.44801240
146tRNA aminoacylation for protein translation (GO:0006418)2.44471005
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.43828700
148glucose catabolic process (GO:0006007)2.43441721
149morphogenesis of an endothelium (GO:0003159)2.42391906
150endothelial tube morphogenesis (GO:0061154)2.42391906
151spliceosomal snRNP assembly (GO:0000387)2.42354891
152peptidyl-proline hydroxylation (GO:0019511)2.42202690
153negative regulation of catenin import into nucleus (GO:0035414)2.40958600
154de novo protein folding (GO:0006458)2.40718285
155positive regulation of receptor recycling (GO:0001921)2.38447491
156adherens junction organization (GO:0034332)2.37881134
157ribonucleoprotein complex biogenesis (GO:0022613)2.37360147
158renal filtration (GO:0097205)2.36740675
159signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36504046
160intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36504046
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36450136
162muscle cell migration (GO:0014812)2.36289631
163positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.36111147
164positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.36078025
165regulation of cholesterol biosynthetic process (GO:0045540)2.35667153
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.35461277
167mitotic recombination (GO:0006312)2.35445395
168establishment of integrated proviral latency (GO:0075713)2.35300561
169deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.35118903
170signal transduction involved in DNA damage checkpoint (GO:0072422)2.34820836
171signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34820836
172protein targeting to plasma membrane (GO:0072661)2.34299246
173cell junction organization (GO:0034330)2.32618348
174positive regulation of nuclease activity (GO:0032075)2.32167100
175endocytic recycling (GO:0032456)2.31669934
176hypotonic response (GO:0006971)2.31274824
177positive regulation of pseudopodium assembly (GO:0031274)2.30825794
178proline metabolic process (GO:0006560)2.29854186
179positive regulation of protein localization to plasma membrane (GO:1903078)2.26618360
180establishment or maintenance of apical/basal cell polarity (GO:0035088)2.26346062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69723035
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83036695
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.71135741
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.50903742
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.02846599
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.01959498
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60594803
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.45464496
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.34723379
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30928281
11XRN2_22483619_ChIP-Seq_HELA_Human2.19384271
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18735135
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10558526
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07916117
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.07904715
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07287396
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03425915
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.02865137
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.97224136
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94845874
21RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93857078
22* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.93358419
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.84746891
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83268958
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.82961455
26E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80823587
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80386140
28MYC_22102868_ChIP-Seq_BL_Human1.78420310
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.77213398
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.76857208
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.75933042
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75823675
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74298069
34KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.73644100
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.73389149
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70220508
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.70083011
38KDM2B_26808549_Chip-Seq_K562_Human1.66497439
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65882463
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.64769902
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63514790
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62902136
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62429824
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60911344
45CLOCK_20551151_ChIP-Seq_293T_Human1.60534587
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59666403
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59094886
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.57358622
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57202441
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.56731306
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.55301896
52KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53251558
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51976350
54DCP1A_22483619_ChIP-Seq_HELA_Human1.51109262
55* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49922686
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49171178
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48940714
58TTF2_22483619_ChIP-Seq_HELA_Human1.47436418
59* VDR_21846776_ChIP-Seq_THP-1_Human1.44921516
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44710402
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44092344
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43508080
63P68_20966046_ChIP-Seq_HELA_Human1.43296684
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.43023644
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42453656
66GABP_19822575_ChIP-Seq_HepG2_Human1.42172347
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41872094
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41485454
69EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.38828569
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.38816950
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.38685759
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37582854
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36345899
74ATF3_27146783_Chip-Seq_COLON_Human1.35537627
75* SA1_27219007_Chip-Seq_ERYTHROID_Human1.35487274
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.35402138
77LXR_22292898_ChIP-Seq_THP-1_Human1.35169857
78ZNF263_19887448_ChIP-Seq_K562_Human1.35150455
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34736772
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34495826
81RACK7_27058665_Chip-Seq_MCF-7_Human1.33303007
82SMC4_20622854_ChIP-Seq_HELA_Human1.32960945
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32041197
84AR_21909140_ChIP-Seq_LNCAP_Human1.31449977
85* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30854533
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30267507
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.30243100
88SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30212469
89TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30074004
90OCT4_18692474_ChIP-Seq_MEFs_Mouse1.29929391
91TCF7_22412390_ChIP-Seq_EML_Mouse1.28714493
92* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.28274640
93CREB1_26743006_Chip-Seq_LNCaP_Human1.27821232
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27402307
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26667182
96TFEB_21752829_ChIP-Seq_HELA_Human1.25960621
97* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25955065
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24552871
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24552871
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24552871
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23876365
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23854063
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23175173
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22711169
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21203285
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20608776
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.20113522
108CIITA_25753668_ChIP-Seq_RAJI_Human1.19450091
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18667619
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.18153644
111CTCF_27219007_Chip-Seq_Bcells_Human1.17600576
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16860371
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16860107
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16860107
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15948281
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14890449
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14169242
118TET1_21490601_ChIP-Seq_MESCs_Mouse1.11777219
119TP63_22573176_ChIP-Seq_HFKS_Human1.10983492
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09677436
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08136767
122YY1_22570637_ChIP-Seq_MALME-3M_Human1.07073884
123SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06344916
124TP53_22127205_ChIP-Seq_IMR90_Human1.06027407
125* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05741096
126E2F1_21310950_ChIP-Seq_MCF-7_Human1.05739684
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04904904
128TRIM28_21343339_ChIP-Seq_HEK293_Human1.04851113
129SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04622708
130SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.04614462
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04547485
132FOXP1_21924763_ChIP-Seq_HESCs_Human1.04144878
133NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03707060
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02860869
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.02792373
136CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02458448
137KDM5A_27292631_Chip-Seq_BREAST_Human1.02292431
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01136119
139SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01019510
140VDR_23849224_ChIP-Seq_CD4+_Human0.99167485
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99132289
142KDM2B_26808549_Chip-Seq_DND41_Human0.98362096
143ELF1_20517297_ChIP-Seq_JURKAT_Human0.97820411
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97609027
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97069268
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.96539681
147NANOG_21062744_ChIP-ChIP_HESCs_Human0.96444190
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96097136
149FOXP3_21729870_ChIP-Seq_TREG_Human0.96016730
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95604721
151ELK1_22589737_ChIP-Seq_MCF10A_Human0.95488059
152ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95482406
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.95146793
154TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94658997
155PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94483357
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93981321
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93619397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.95088510
2MP0003705_abnormal_hypodermis_morpholog3.18549211
3MP0010352_gastrointestinal_tract_polyps2.91650270
4MP0000579_abnormal_nail_morphology2.73456799
5MP0002877_abnormal_melanocyte_morpholog2.65980980
6MP0004957_abnormal_blastocyst_morpholog2.64653627
7MP0000537_abnormal_urethra_morphology2.58408072
8MP0003693_abnormal_embryo_hatching2.49729020
9MP0003283_abnormal_digestive_organ2.49048521
10MP0010234_abnormal_vibrissa_follicle2.41048326
11MP0003566_abnormal_cell_adhesion2.26913795
12MP0008438_abnormal_cutaneous_collagen2.22692636
13MP0003111_abnormal_nucleus_morphology2.18740625
14MP0002060_abnormal_skin_morphology2.15024273
15MP0005409_darkened_coat_color2.13521324
16MP0004133_heterotaxia2.10950119
17MP0003077_abnormal_cell_cycle2.07670497
18MP0009053_abnormal_anal_canal2.03667941
19MP0005058_abnormal_lysosome_morphology2.03160708
20MP0002653_abnormal_ependyma_morphology2.00310975
21MP0005451_abnormal_body_composition1.97516154
22MP0003119_abnormal_digestive_system1.96697817
23MP0000678_abnormal_parathyroid_gland1.96550896
24MP0005623_abnormal_meninges_morphology1.92197227
25MP0008932_abnormal_embryonic_tissue1.92186121
26MP0004272_abnormal_basement_membrane1.83469544
27MP0000566_synostosis1.83354939
28MP0006054_spinal_hemorrhage1.83279765
29MP0008007_abnormal_cellular_replicative1.81804440
30MP0001730_embryonic_growth_arrest1.79900120
31MP0001849_ear_inflammation1.73549231
32MP0003123_paternal_imprinting1.72491095
33MP0004185_abnormal_adipocyte_glucose1.70675567
34MP0005275_abnormal_skin_tensile1.69790323
35MP0002249_abnormal_larynx_morphology1.69153544
36MP0004858_abnormal_nervous_system1.67221844
37MP0009780_abnormal_chondrocyte_physiolo1.65644191
38MP0005501_abnormal_skin_physiology1.63106985
39MP0010094_abnormal_chromosome_stability1.60295604
40MP0001216_abnormal_epidermal_layer1.59482834
41MP0009840_abnormal_foam_cell1.58847184
42MP0005076_abnormal_cell_differentiation1.56223526
43MP0003941_abnormal_skin_development1.56135304
44MP0008260_abnormal_autophagy1.54695861
45MP0009379_abnormal_foot_pigmentation1.52626673
46MP0000003_abnormal_adipose_tissue1.50540728
47MP0004197_abnormal_fetal_growth/weight/1.49965016
48MP0002085_abnormal_embryonic_tissue1.49156616
49* MP0000350_abnormal_cell_proliferation1.48846568
50* MP0005023_abnormal_wound_healing1.46878766
51MP0000733_abnormal_muscle_development1.43902144
52MP0002084_abnormal_developmental_patter1.43438473
53MP0000751_myopathy1.43117577
54MP0003942_abnormal_urinary_system1.39000228
55MP0001697_abnormal_embryo_size1.38636846
56MP0010771_integument_phenotype1.37168254
57MP0001348_abnormal_lacrimal_gland1.37125397
58MP0003191_abnormal_cellular_cholesterol1.36133174
59MP0002080_prenatal_lethality1.34177755
60MP0000534_abnormal_ureter_morphology1.33964681
61MP0001672_abnormal_embryogenesis/_devel1.33414457
62MP0005380_embryogenesis_phenotype1.33414457
63MP0010368_abnormal_lymphatic_system1.32353848
64MP0002111_abnormal_tail_morphology1.27282723
65MP0003385_abnormal_body_wall1.27107700
66MP0003984_embryonic_growth_retardation1.26810857
67MP0003115_abnormal_respiratory_system1.24850513
68MP0002697_abnormal_eye_size1.23659296
69MP0010307_abnormal_tumor_latency1.23466687
70MP0002088_abnormal_embryonic_growth/wei1.22806026
71MP0003279_aneurysm1.21494512
72MP0002796_impaired_skin_barrier1.20831633
73MP0002086_abnormal_extraembryonic_tissu1.18067147
74MP0005257_abnormal_intraocular_pressure1.16116310
75MP0000490_abnormal_crypts_of1.15790147
76MP0009384_cardiac_valve_regurgitation1.15650676
77MP0003315_abnormal_perineum_morphology1.15221277
78MP0003329_amyloid_beta_deposits1.14645820
79MP0003122_maternal_imprinting1.14416139
80MP0000762_abnormal_tongue_morphology1.13905012
81MP0001958_emphysema1.13434693
82MP0002089_abnormal_postnatal_growth/wei1.11454597
83MP0000013_abnormal_adipose_tissue1.09453009
84MP0005375_adipose_tissue_phenotype1.08826989
85MP0002896_abnormal_bone_mineralization1.08677012
86MP0002282_abnormal_trachea_morphology1.08482204
87MP0002932_abnormal_joint_morphology1.07998594
88MP0000462_abnormal_digestive_system1.07479900
89MP0004782_abnormal_surfactant_physiolog1.07379435
90MP0000428_abnormal_craniofacial_morphol1.07049268
91MP0002751_abnormal_autonomic_nervous1.06372649
92MP0000049_abnormal_middle_ear1.05985175
93MP0000750_abnormal_muscle_regeneration1.05466713
94MP0010678_abnormal_skin_adnexa1.03198405
95MP0008789_abnormal_olfactory_epithelium1.01939128
96MP0000858_altered_metastatic_potential1.01128018
97MP0003453_abnormal_keratinocyte_physiol1.00464137
98MP0002234_abnormal_pharynx_morphology0.98860822
99MP0000467_abnormal_esophagus_morphology0.98210933
100MP0001243_abnormal_dermal_layer0.94133628
101MP0005666_abnormal_adipose_tissue0.93616485
102MP0005377_hearing/vestibular/ear_phenot0.91313282
103MP0003878_abnormal_ear_physiology0.91313282
104MP0003567_abnormal_fetal_cardiomyocyte0.91098789
105MP0005508_abnormal_skeleton_morphology0.90897204
106MP0000627_abnormal_mammary_gland0.90528284
107MP0000358_abnormal_cell_content/0.89713853
108MP0001915_intracranial_hemorrhage0.88988580
109MP0000313_abnormal_cell_death0.88375257
110MP0009931_abnormal_skin_appearance0.87650011
111MP0003091_abnormal_cell_migration0.87326042
112MP0002092_abnormal_eye_morphology0.86568263
113MP0003937_abnormal_limbs/digits/tail_de0.84877486
114MP0000767_abnormal_smooth_muscle0.84398946
115MP0001293_anophthalmia0.81635798
116MP0003121_genomic_imprinting0.81605270
117MP0002098_abnormal_vibrissa_morphology0.81563703
118MP0008058_abnormal_DNA_repair0.81178364
119MP0002269_muscular_atrophy0.80964825
120MP0004233_abnormal_muscle_weight0.80009102
121MP0004381_abnormal_hair_follicle0.79015910
122MP0003755_abnormal_palate_morphology0.78962409
123MP0004084_abnormal_cardiac_muscle0.78746089
124MP0000681_abnormal_thyroid_gland0.78472895
125MP0000377_abnormal_hair_follicle0.77778954
126MP0008770_decreased_survivor_rate0.77374121
127MP0002233_abnormal_nose_morphology0.76516654
128MP0003861_abnormal_nervous_system0.76223845
129MP0000747_muscle_weakness0.76163244
130MP0005503_abnormal_tendon_morphology0.75081208
131MP0005193_abnormal_anterior_eye0.74997792
132MP0000759_abnormal_skeletal_muscle0.73475396
133MP0000477_abnormal_intestine_morphology0.71512923
134* MP0002925_abnormal_cardiovascular_devel0.71345754
135MP0002114_abnormal_axial_skeleton0.70889004
136MP0004264_abnormal_extraembryonic_tissu0.70882056
137MP0002116_abnormal_craniofacial_bone0.70605408
138MP0004947_skin_inflammation0.70543913
139MP0006138_congestive_heart_failure0.70121422
140MP0001881_abnormal_mammary_gland0.69713405
141MP0005670_abnormal_white_adipose0.69509271
142MP0003634_abnormal_glial_cell0.69501803
143MP0005621_abnormal_cell_physiology0.67013925
144MP0001340_abnormal_eyelid_morphology0.64648627
145MP0004087_abnormal_muscle_fiber0.62873625
146MP0009672_abnormal_birth_weight0.61889447
147MP0005197_abnormal_uvea_morphology0.61197061
148MP0001299_abnormal_eye_distance/0.60687279
149MP0005165_increased_susceptibility_to0.59945877
150MP0001346_abnormal_lacrimal_gland0.59897572
151MP0005083_abnormal_biliary_tract0.59161162

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.19472913
2Distal lower limb muscle weakness (HP:0009053)3.41983339
3Premature rupture of membranes (HP:0001788)3.29381408
4Selective tooth agenesis (HP:0001592)3.04180187
5Trismus (HP:0000211)3.02915298
6Short nail (HP:0001799)3.00200415
7Renal duplication (HP:0000075)2.97120313
8Distal lower limb amyotrophy (HP:0008944)2.87834538
9Flat acetabular roof (HP:0003180)2.79490279
10Abnormality of the Achilles tendon (HP:0005109)2.72999118
11Shallow orbits (HP:0000586)2.70307908
12Degeneration of anterior horn cells (HP:0002398)2.66459095
13Abnormality of the anterior horn cell (HP:0006802)2.66459095
14Mildly elevated creatine phosphokinase (HP:0008180)2.63805384
15Broad face (HP:0000283)2.63197046
16Stridor (HP:0010307)2.59945685
17Spinal cord compression (HP:0002176)2.55358958
18Multiple enchondromatosis (HP:0005701)2.54288011
19Fragile skin (HP:0001030)2.51304180
20Abnormality of nail color (HP:0100643)2.49878538
21Ependymoma (HP:0002888)2.47716075
22Ankle contracture (HP:0006466)2.45152761
23Difficulty climbing stairs (HP:0003551)2.44763286
24Aplasia/Hypoplasia of the sacrum (HP:0008517)2.43593943
25Natal tooth (HP:0000695)2.43003353
26Cerebral aneurysm (HP:0004944)2.41590596
27Missing ribs (HP:0000921)2.38822571
28Reticulocytopenia (HP:0001896)2.37971657
29Angiofibromas (HP:0010615)2.37685282
30Adenoma sebaceum (HP:0009720)2.37685282
31Milia (HP:0001056)2.35912959
32Elbow flexion contracture (HP:0002987)2.30775194
33Hyperparathyroidism (HP:0000843)2.28299406
34Thin bony cortex (HP:0002753)2.26952821
35Pili torti (HP:0003777)2.25530941
36Astrocytoma (HP:0009592)2.24063353
37Abnormality of the astrocytes (HP:0100707)2.24063353
38Vertebral compression fractures (HP:0002953)2.22958197
39Advanced eruption of teeth (HP:0006288)2.21933639
40J-shaped sella turcica (HP:0002680)2.21750195
41Bladder diverticulum (HP:0000015)2.20734763
42Abnormality of the calcaneus (HP:0008364)2.20094024
43Atrophic scars (HP:0001075)2.17039559
44Abnormality of dentin (HP:0010299)2.16558599
45Nail dystrophy (HP:0008404)2.16415310
46Mitral regurgitation (HP:0001653)2.14796463
47Axonal loss (HP:0003447)2.12518859
48Obstructive sleep apnea (HP:0002870)2.12117609
49Cerebral hypomyelination (HP:0006808)2.11285994
50Alopecia of scalp (HP:0002293)2.08764896
51Hyperacusis (HP:0010780)2.07946643
52Ankyloglossia (HP:0010296)2.07409346
53Arterial tortuosity (HP:0005116)2.07393795
54Generalized amyotrophy (HP:0003700)2.07040674
55Vascular tortuosity (HP:0004948)2.06885057
56Pterygium (HP:0001059)2.04676349
57Abnormality of carpal bone ossification (HP:0006257)2.04318467
58Hand muscle atrophy (HP:0009130)2.03171261
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.02772775
60Osteolytic defects of the hand bones (HP:0009699)2.02772775
61Onycholysis (HP:0001806)2.02638533
62Acanthosis nigricans (HP:0000956)2.02214197
63Lower limb amyotrophy (HP:0007210)1.99460054
64Myopathic facies (HP:0002058)1.99379426
65Abnormal ossification of hand bones (HP:0005921)1.98165300
66Distal upper limb amyotrophy (HP:0007149)1.98022605
67Upper limb amyotrophy (HP:0009129)1.98022605
68Genu recurvatum (HP:0002816)1.97000986
69Colon cancer (HP:0003003)1.96974393
70Bowel diverticulosis (HP:0005222)1.96747349
71Soft skin (HP:0000977)1.96618061
72Abnormal number of incisors (HP:0011064)1.95769032
73Abnormality of the distal phalanx of the thumb (HP:0009617)1.95295157
74Disproportionate tall stature (HP:0001519)1.93979635
75Slender long bone (HP:0003100)1.93935667
76Plantar hyperkeratosis (HP:0007556)1.93718375
77Neoplasm of the pancreas (HP:0002894)1.92228608
78Breast hypoplasia (HP:0003187)1.92094878
79Neonatal short-limb short stature (HP:0008921)1.91547447
80Congenital glaucoma (HP:0001087)1.91151079
81Microretrognathia (HP:0000308)1.90533730
82Blue sclerae (HP:0000592)1.89765770
83Back pain (HP:0003418)1.89492678
84Calcaneovalgus deformity (HP:0001848)1.87886542
85Increased connective tissue (HP:0009025)1.87662484
86Achilles tendon contracture (HP:0001771)1.87605618
87Deviation of the hallux (HP:0010051)1.86022883
88Bowed forearm bones (HP:0003956)1.84393642
89Bowing of the arm (HP:0006488)1.84393642
90Abnormality of the distal phalanges of the toes (HP:0010182)1.84351477
91Flattened epiphyses (HP:0003071)1.82517900
92Ridged nail (HP:0001807)1.82494484
93Abnormal hair laboratory examination (HP:0003328)1.82302616
94Long palpebral fissure (HP:0000637)1.81944460
95Fragile nails (HP:0001808)1.81782520
96Peritonitis (HP:0002586)1.81555445
97Limb-girdle muscle atrophy (HP:0003797)1.80476897
98Asymmetry of the thorax (HP:0001555)1.79688549
99Scapular winging (HP:0003691)1.79623456
100Lymphangioma (HP:0100764)1.79201583
101Atrophy/Degeneration involving motor neurons (HP:0007373)1.78954408
102Increased variability in muscle fiber diameter (HP:0003557)1.78897260
103Thick nail (HP:0001805)1.77890982
104Long toe (HP:0010511)1.77881737
105Right ventricular cardiomyopathy (HP:0011663)1.76973233
106Wrist flexion contracture (HP:0001239)1.76924574
107Down-sloping shoulders (HP:0200021)1.76789866
108Hallux valgus (HP:0001822)1.76687025
109Abnormality of oral frenula (HP:0000190)1.76566704
110Glossoptosis (HP:0000162)1.75101382
111Nuclear cataract (HP:0100018)1.74904686
112Broad distal phalanx of finger (HP:0009836)1.74817141
113Coxa vara (HP:0002812)1.72840253
114Abdominal distention (HP:0003270)1.72551247
115Abnormality of the umbilical cord (HP:0010881)1.72268123
116Short 5th finger (HP:0009237)1.71310588
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.71165104
118Abdominal situs inversus (HP:0003363)1.71146902
119Abnormality of abdominal situs (HP:0011620)1.71146902
120Biconcave vertebral bodies (HP:0004586)1.71092472
121Adducted thumb (HP:0001181)1.70623852
122Abnormality of the acetabulum (HP:0003170)1.70505911
123Deformed tarsal bones (HP:0008119)1.70189594
124Cervical subluxation (HP:0003308)1.70102558
125Cerebral inclusion bodies (HP:0100314)1.69912102
126Hypercalcemia (HP:0003072)1.68993879
127Fasciculations (HP:0002380)1.68083540
128Aortic dissection (HP:0002647)1.67639442
129Dilatation of the ascending aorta (HP:0005111)1.66910051
130Hypoplasia of the pons (HP:0012110)1.66677316
131Increased density of long bones (HP:0006392)1.66591275
132Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.66438884
133Vertebral hypoplasia (HP:0008417)1.66438884
134Ulnar bowing (HP:0003031)1.66296550
135Patellar dislocation (HP:0002999)1.64872589
136Glioma (HP:0009733)1.64805483
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64556434
138Abnormal hemoglobin (HP:0011902)1.64427917
139Patellar aplasia (HP:0006443)1.63635932
140Aplasia/Hypoplasia of the patella (HP:0006498)1.63603286
141Spinal rigidity (HP:0003306)1.63588855
142Pelvic girdle muscle weakness (HP:0003749)1.62332041
143Abnormality of cells of the erythroid lineage (HP:0012130)1.62318828
144Fibroma (HP:0010614)1.62008773
145Wormian bones (HP:0002645)1.61666323
146Abnormal umbilical cord blood vessels (HP:0011403)1.60848639
147Single umbilical artery (HP:0001195)1.60848639
148Abnormality of the fetal cardiovascular system (HP:0010948)1.60848639
149Malignant gastrointestinal tract tumors (HP:0006749)1.59830587
150Gastrointestinal carcinoma (HP:0002672)1.59830587
151Reduced subcutaneous adipose tissue (HP:0003758)1.59706766
152Hypotrichosis (HP:0001006)1.59456313
153Aortic aneurysm (HP:0004942)1.59131332
154Pointed chin (HP:0000307)1.59053280
155Broad metatarsal (HP:0001783)1.58978482
156Insomnia (HP:0100785)1.58594511
157Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.57435265
158Short 4th metacarpal (HP:0010044)1.57435265
159Overriding aorta (HP:0002623)1.57290333
160Abnormality of skeletal muscle fiber size (HP:0012084)1.57109231
161Bulbar palsy (HP:0001283)1.55079292
162Hyperextensible skin (HP:0000974)1.54783924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.65564397
2TRIB33.59747969
3TESK23.29173831
4MST1R3.19618520
5SMG13.17166077
6SIK13.15717998
7TESK12.94942062
8PKN22.90239652
9EPHA22.77167516
10IRAK32.76952895
11LIMK12.36648369
12NEK12.13624922
13MAPKAPK32.09111297
14MAP3K112.03734576
15RPS6KB22.00106284
16PAK41.99606356
17SCYL21.93003084
18NME21.88180070
19ICK1.75740301
20LATS21.73419968
21ERN11.68870719
22KDR1.65672067
23WEE11.65244630
24MAP3K101.62088009
25EEF2K1.60292179
26PIM21.57625317
27TGFBR11.52953476
28NEK21.50241101
29PRPF4B1.49773943
30LRRK21.49003725
31PRKD31.47375043
32MAP3K81.44886326
33EPHB21.41890440
34CDC71.39915846
35AURKA1.36282976
36PASK1.31485383
37MAP3K31.30205017
38MAP2K31.29968036
39TTN1.25626460
40TAOK11.24882159
41TTK1.19515564
42TLK11.15671486
43TAOK21.15265460
44ILK1.13441448
45ARAF1.12877775
46CDK71.12024432
47LMTK21.11095020
48PTK21.09100328
49RPS6KA41.06872529
50PAK11.05371896
51DAPK31.01161041
52EPHB10.99096477
53PLK10.97330771
54DDR20.97298233
55ACVR1B0.95949346
56STK100.95277752
57RPS6KA20.94823742
58PTK60.94656629
59FER0.94606406
60PRKD20.92736756
61MET0.91850893
62PAK20.90746867
63KSR10.90502245
64TYRO30.89526506
65PDGFRA0.89193465
66ABL20.87040795
67MAP2K20.86760260
68MYLK0.86189847
69BRSK10.83890131
70STK380.80472928
71FLT30.80366577
72AURKB0.79248512
73BMX0.79107800
74UHMK10.78591379
75FGFR40.78184871
76CDK120.77642815
77PDPK10.74797496
78PRKCI0.73959133
79FGFR10.72735862
80KSR20.72174607
81MAP3K90.71001104
82PRKG20.70080099
83MAP3K60.69924633
84CDK140.69547704
85BRAF0.68093224
86EIF2AK10.66816444
87CAMK2G0.64766961
88MAP3K20.64322161
89CDC42BPA0.63284389
90IRAK20.63177164
91DYRK30.63129205
92CDK80.61914204
93ERBB40.60955185
94MAP2K10.60650711
95DYRK20.60532498
96BLK0.59485740
97CDK180.58903726
98STK160.58838852
99MAP3K10.57447392
100MTOR0.56780497
101BCR0.56650642
102DMPK0.55339742
103CDK11A0.55241146
104MOS0.55186687
105MUSK0.55059400
106CDK150.54340000
107VRK20.53584139
108AKT20.53257377
109MINK10.52618919
110ALK0.52546898
111MAPKAPK20.50727158
112MARK20.49836274
113RPS6KL10.47873488
114RPS6KC10.47873488
115PBK0.46195509
116MAP3K130.46012877
117ATR0.45920519
118CHEK20.45615602
119CAMK2B0.45380725
120ROCK10.44805072
121ROCK20.44397151
122CHEK10.40473274
123STK38L0.39161992
124NTRK10.38324245
125MAPK110.37961144
126CLK10.37451536
127DYRK1B0.36459981
128MATK0.35989552
129CAMK2D0.34492362
130PLK30.34349816
131ERBB20.34318770
132PAK30.32689984
133RIPK10.32357341
134PDGFRB0.32238500
135TBK10.32047704
136DAPK10.31618223
137RET0.30371142
138HIPK20.30050842
139PHKG10.28568459
140PHKG20.28568459
141RPS6KA60.28349522

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89824294
2Mismatch repair_Homo sapiens_hsa034303.14434558
3Ribosome_Homo sapiens_hsa030103.12610298
4Proteasome_Homo sapiens_hsa030502.95788901
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53954538
6Spliceosome_Homo sapiens_hsa030402.35688143
7Base excision repair_Homo sapiens_hsa034102.35335086
8Cell cycle_Homo sapiens_hsa041102.15418349
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.09108405
10RNA transport_Homo sapiens_hsa030132.02372107
11Nucleotide excision repair_Homo sapiens_hsa034201.92680741
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.90602172
13Bladder cancer_Homo sapiens_hsa052191.83715655
14Fructose and mannose metabolism_Homo sapiens_hsa000511.80568379
15Hippo signaling pathway_Homo sapiens_hsa043901.76645891
16Basal cell carcinoma_Homo sapiens_hsa052171.67759618
17p53 signaling pathway_Homo sapiens_hsa041151.66509135
18One carbon pool by folate_Homo sapiens_hsa006701.65578412
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65535982
20Prion diseases_Homo sapiens_hsa050201.57044294
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52215223
22Shigellosis_Homo sapiens_hsa051311.49245947
23RNA polymerase_Homo sapiens_hsa030201.48794170
24Vitamin B6 metabolism_Homo sapiens_hsa007501.48632857
25Pyrimidine metabolism_Homo sapiens_hsa002401.43891680
26Homologous recombination_Homo sapiens_hsa034401.37381457
27Hedgehog signaling pathway_Homo sapiens_hsa043401.33665215
28Sulfur metabolism_Homo sapiens_hsa009201.30746568
29Tight junction_Homo sapiens_hsa045301.29246428
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26174225
31Notch signaling pathway_Homo sapiens_hsa043301.23915452
32Adherens junction_Homo sapiens_hsa045201.22562349
33Chronic myeloid leukemia_Homo sapiens_hsa052201.22268283
34Small cell lung cancer_Homo sapiens_hsa052221.20506811
35mRNA surveillance pathway_Homo sapiens_hsa030151.15730218
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15590771
37Thyroid cancer_Homo sapiens_hsa052161.15461982
38MicroRNAs in cancer_Homo sapiens_hsa052061.15460492
39Insulin signaling pathway_Homo sapiens_hsa049101.10766669
40Proteoglycans in cancer_Homo sapiens_hsa052051.10565931
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08088215
42Phenylalanine metabolism_Homo sapiens_hsa003601.07429530
43ErbB signaling pathway_Homo sapiens_hsa040121.07129044
44Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06726979
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04225666
46Viral carcinogenesis_Homo sapiens_hsa052031.03521714
47Colorectal cancer_Homo sapiens_hsa052101.01557274
48Oocyte meiosis_Homo sapiens_hsa041141.01201024
49Epstein-Barr virus infection_Homo sapiens_hsa051691.00448660
50Sulfur relay system_Homo sapiens_hsa041220.99820956
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98947621
52AMPK signaling pathway_Homo sapiens_hsa041520.98934472
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98685230
54HTLV-I infection_Homo sapiens_hsa051660.98044630
55Focal adhesion_Homo sapiens_hsa045100.96796095
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96442567
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96018446
58Vibrio cholerae infection_Homo sapiens_hsa051100.95822759
59Dilated cardiomyopathy_Homo sapiens_hsa054140.94678386
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.93990539
61VEGF signaling pathway_Homo sapiens_hsa043700.91941625
62Arginine biosynthesis_Homo sapiens_hsa002200.91402980
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88342178
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88231371
65Apoptosis_Homo sapiens_hsa042100.85603867
66Melanoma_Homo sapiens_hsa052180.85020459
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84547593
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.83969484
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83120216
70Arginine and proline metabolism_Homo sapiens_hsa003300.82418425
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.82414736
72Estrogen signaling pathway_Homo sapiens_hsa049150.82210152
73ECM-receptor interaction_Homo sapiens_hsa045120.81369972
74TGF-beta signaling pathway_Homo sapiens_hsa043500.80358167
75GnRH signaling pathway_Homo sapiens_hsa049120.80013205
76Sphingolipid metabolism_Homo sapiens_hsa006000.78890329
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.78800987
78Pathways in cancer_Homo sapiens_hsa052000.78472223
79Endometrial cancer_Homo sapiens_hsa052130.78438824
80Biosynthesis of amino acids_Homo sapiens_hsa012300.77387654
81Glioma_Homo sapiens_hsa052140.74233481
82N-Glycan biosynthesis_Homo sapiens_hsa005100.73731781
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72282118
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70821232
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70665921
86Pancreatic cancer_Homo sapiens_hsa052120.69614714
87HIF-1 signaling pathway_Homo sapiens_hsa040660.69425556
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68300708
89Hepatitis C_Homo sapiens_hsa051600.67942539
90Systemic lupus erythematosus_Homo sapiens_hsa053220.67414850
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66581040
92Viral myocarditis_Homo sapiens_hsa054160.65872233
93Non-small cell lung cancer_Homo sapiens_hsa052230.64563055
94Glutathione metabolism_Homo sapiens_hsa004800.64071287
95mTOR signaling pathway_Homo sapiens_hsa041500.63850987
96Salmonella infection_Homo sapiens_hsa051320.63225975
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.62736149
98Galactose metabolism_Homo sapiens_hsa000520.61877686
99Synaptic vesicle cycle_Homo sapiens_hsa047210.61810793
100Legionellosis_Homo sapiens_hsa051340.61596060
101Inositol phosphate metabolism_Homo sapiens_hsa005620.61503507
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.61003445
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60883560
104Pentose phosphate pathway_Homo sapiens_hsa000300.60793616
105Endocytosis_Homo sapiens_hsa041440.60537286
106Tyrosine metabolism_Homo sapiens_hsa003500.59089125
107Carbon metabolism_Homo sapiens_hsa012000.57406570
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57185291
109Folate biosynthesis_Homo sapiens_hsa007900.56791934
110Wnt signaling pathway_Homo sapiens_hsa043100.56180553
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55977673
112Melanogenesis_Homo sapiens_hsa049160.55816575
113Renal cell carcinoma_Homo sapiens_hsa052110.55198038
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55148358
115Alcoholism_Homo sapiens_hsa050340.54870708
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54563761
117Rap1 signaling pathway_Homo sapiens_hsa040150.54480049
118Insulin resistance_Homo sapiens_hsa049310.53880589
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.53442286
120Glucagon signaling pathway_Homo sapiens_hsa049220.53154906
121Parkinsons disease_Homo sapiens_hsa050120.52866545
122Lysosome_Homo sapiens_hsa041420.52013002
123Prostate cancer_Homo sapiens_hsa052150.51624142
124Bile secretion_Homo sapiens_hsa049760.51611909
125Choline metabolism in cancer_Homo sapiens_hsa052310.51038825
126Acute myeloid leukemia_Homo sapiens_hsa052210.50681567
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50388109
128Protein digestion and absorption_Homo sapiens_hsa049740.49973310
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49873790
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49159066
131Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47683177
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47616592
133Other glycan degradation_Homo sapiens_hsa005110.46669235
134Axon guidance_Homo sapiens_hsa043600.45160325
135Amoebiasis_Homo sapiens_hsa051460.43716771
136Gap junction_Homo sapiens_hsa045400.42833541
137Huntingtons disease_Homo sapiens_hsa050160.40377803

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