GINS4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)4.89059191
2DNA replication initiation (GO:0006270)4.76264956
3telomere maintenance via semi-conservative replication (GO:0032201)4.71293869
4* DNA strand elongation (GO:0022616)4.62638617
5maturation of SSU-rRNA (GO:0030490)4.60645164
6DNA replication checkpoint (GO:0000076)4.59983676
7DNA deamination (GO:0045006)4.53146890
8ribosomal small subunit assembly (GO:0000028)4.39332380
9nucleobase biosynthetic process (GO:0046112)4.33935344
10formation of translation preinitiation complex (GO:0001731)4.32422624
11purine nucleobase biosynthetic process (GO:0009113)4.30697756
12telomere maintenance via recombination (GO:0000722)4.25715808
13DNA unwinding involved in DNA replication (GO:0006268)4.21038686
14mitotic metaphase plate congression (GO:0007080)4.11110256
15mitotic recombination (GO:0006312)4.03325341
16CENP-A containing nucleosome assembly (GO:0034080)4.02589672
17viral transcription (GO:0019083)4.01155423
18ribosome assembly (GO:0042255)4.00933234
19proteasome assembly (GO:0043248)3.99725485
20chromatin remodeling at centromere (GO:0031055)3.98627404
21translational termination (GO:0006415)3.98040946
22ribosomal small subunit biogenesis (GO:0042274)3.94927208
23telomere maintenance via telomere lengthening (GO:0010833)3.91404295
24ribosomal large subunit biogenesis (GO:0042273)3.85434061
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82787440
26sister chromatid segregation (GO:0000819)3.81285531
27DNA replication-dependent nucleosome organization (GO:0034723)3.80317178
28DNA replication-dependent nucleosome assembly (GO:0006335)3.80317178
29protein localization to kinetochore (GO:0034501)3.78942712
30replication fork processing (GO:0031297)3.73495357
31somatic diversification of immune receptors via somatic mutation (GO:0002566)3.73299085
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.73299085
33ribonucleoprotein complex biogenesis (GO:0022613)3.72831379
34translational initiation (GO:0006413)3.69681985
35ribosome biogenesis (GO:0042254)3.67541178
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.64807327
37translational elongation (GO:0006414)3.63402244
38DNA replication-independent nucleosome organization (GO:0034724)3.59425826
39DNA replication-independent nucleosome assembly (GO:0006336)3.59425826
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.55760137
41kinetochore organization (GO:0051383)3.55269849
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52578966
43metaphase plate congression (GO:0051310)3.52384124
44protein K6-linked ubiquitination (GO:0085020)3.52377943
45rRNA processing (GO:0006364)3.49697458
46spliceosomal snRNP assembly (GO:0000387)3.47667773
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.47595117
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45674593
49mitotic nuclear envelope disassembly (GO:0007077)3.44998848
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44830663
51meiotic chromosome segregation (GO:0045132)3.44545699
52negative regulation of DNA-dependent DNA replication (GO:2000104)3.43801729
53protein localization to chromosome, centromeric region (GO:0071459)3.41064203
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40833485
55SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40666521
56rRNA metabolic process (GO:0016072)3.38200650
57histone exchange (GO:0043486)3.35315530
58kinetochore assembly (GO:0051382)3.35279458
59transcription-coupled nucleotide-excision repair (GO:0006283)3.34327715
60cotranslational protein targeting to membrane (GO:0006613)3.33857014
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.32829121
62rRNA modification (GO:0000154)3.32023952
63protein targeting to ER (GO:0045047)3.31608883
64termination of RNA polymerase III transcription (GO:0006386)3.31345380
65transcription elongation from RNA polymerase III promoter (GO:0006385)3.31345380
66attachment of spindle microtubules to kinetochore (GO:0008608)3.30793226
67folic acid-containing compound biosynthetic process (GO:0009396)3.29099256
68regulation of DNA endoreduplication (GO:0032875)3.28265293
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27342102
70negative regulation of ligase activity (GO:0051352)3.27342102
71maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.26203131
72heterochromatin organization (GO:0070828)3.25540904
73translesion synthesis (GO:0019985)3.25437338
74DNA catabolic process, exonucleolytic (GO:0000738)3.24940122
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22599907
76regulation of centriole replication (GO:0046599)3.21487582
77postreplication repair (GO:0006301)3.21085410
78IMP biosynthetic process (GO:0006188)3.20402175
79DNA strand renaturation (GO:0000733)3.18776687
80recombinational repair (GO:0000725)3.18264497
81DNA double-strand break processing (GO:0000729)3.17739399
82cell cycle G1/S phase transition (GO:0044843)3.17073373
83G1/S transition of mitotic cell cycle (GO:0000082)3.17073373
84double-strand break repair via homologous recombination (GO:0000724)3.16507069
85cellular protein complex disassembly (GO:0043624)3.15870648
86regulation of mitotic spindle checkpoint (GO:1903504)3.15543503
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15543503
88establishment of protein localization to mitochondrial membrane (GO:0090151)3.15371479
89membrane disassembly (GO:0030397)3.15214361
90nuclear envelope disassembly (GO:0051081)3.15214361
91establishment of chromosome localization (GO:0051303)3.15201300
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14547341
93protein localization to endoplasmic reticulum (GO:0070972)3.13792158
94regulation of spindle organization (GO:0090224)3.13196572
95pseudouridine synthesis (GO:0001522)3.13125153
96regulation of posttranscriptional gene silencing (GO:0060147)3.10851400
97regulation of gene silencing by miRNA (GO:0060964)3.10851400
98regulation of gene silencing by RNA (GO:0060966)3.10851400
99viral life cycle (GO:0019058)3.10732532
100translation (GO:0006412)3.08888444
101establishment of integrated proviral latency (GO:0075713)3.04682307
102positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04421183
103mitotic sister chromatid segregation (GO:0000070)3.03843544
104L-serine metabolic process (GO:0006563)3.02033673
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.01982435
1067-methylguanosine mRNA capping (GO:0006370)3.01802695
107folic acid metabolic process (GO:0046655)3.00939051
108mitotic chromosome condensation (GO:0007076)3.00003760
109telomere organization (GO:0032200)2.99879639
110DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99159233
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.99096378
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.99096378
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.99096378
114negative regulation of sister chromatid segregation (GO:0033046)2.99096378
115spindle checkpoint (GO:0031577)2.98935848
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98717623
117negative regulation of chromosome segregation (GO:0051985)2.98601062
118establishment of viral latency (GO:0019043)2.98473745
119positive regulation of chromosome segregation (GO:0051984)2.98166132
120telomere maintenance (GO:0000723)2.97499782
121IMP metabolic process (GO:0046040)2.96327625
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95738289
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95738289
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.95506584
1257-methylguanosine RNA capping (GO:0009452)2.95174460
126RNA capping (GO:0036260)2.95174460
127signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.94874989
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.94874989
129nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.91723855
130mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90851844
131double-strand break repair via nonhomologous end joining (GO:0006303)2.90704812
132non-recombinational repair (GO:0000726)2.90704812
133chromatin assembly or disassembly (GO:0006333)2.90700278
134synapsis (GO:0007129)2.89965946
135DNA ligation (GO:0006266)2.88966336
136regulation of centrosome cycle (GO:0046605)2.87394110
137maturation of 5.8S rRNA (GO:0000460)2.87070662
138regulation of mitochondrial translation (GO:0070129)2.86467131
139mitochondrial RNA metabolic process (GO:0000959)2.83406373
140DNA damage response, detection of DNA damage (GO:0042769)2.82440010
141ATP-dependent chromatin remodeling (GO:0043044)2.80617541
142chromosome segregation (GO:0007059)2.79012859
143DNA recombination (GO:0006310)2.76471537
144* DNA replication (GO:0006260)2.75690561
145DNA-dependent DNA replication (GO:0006261)2.75684426
146somatic recombination of immunoglobulin gene segments (GO:0016447)2.74959967
147regulation of chromosome segregation (GO:0051983)2.74665755
148somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74429693
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74429693
150isotype switching (GO:0045190)2.74429693
151protein localization to chromosome (GO:0034502)2.73644173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07546734
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.28456038
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78413229
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.55818428
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.50406493
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49085647
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.18869286
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.16126510
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11979885
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01062297
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.99639292
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97708313
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95583257
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89154589
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.88068515
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50963146
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.50117923
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48056709
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44448331
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39242046
21XRN2_22483619_ChIP-Seq_HELA_Human2.38290883
22* VDR_23849224_ChIP-Seq_CD4+_Human2.35099584
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33050477
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31286506
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26326928
26AR_21909140_ChIP-Seq_LNCAP_Human2.14322428
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13257712
28ZNF274_21170338_ChIP-Seq_K562_Hela2.07180146
29DCP1A_22483619_ChIP-Seq_HELA_Human2.06535298
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03867529
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01613266
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99999348
33GABP_19822575_ChIP-Seq_HepG2_Human1.94991309
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.94352385
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91739463
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87916443
37TTF2_22483619_ChIP-Seq_HELA_Human1.83629076
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.82935696
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75499431
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74960051
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72655194
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71440181
43EWS_26573619_Chip-Seq_HEK293_Human1.65698864
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65505595
45ELK1_19687146_ChIP-ChIP_HELA_Human1.60781678
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.60386611
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60330055
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.55210589
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55095188
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53738963
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49388873
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48603530
53IRF1_19129219_ChIP-ChIP_H3396_Human1.47270686
54VDR_22108803_ChIP-Seq_LS180_Human1.46755903
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.46734880
56YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44651521
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.44142679
58CIITA_25753668_ChIP-Seq_RAJI_Human1.40595471
59KDM5A_27292631_Chip-Seq_BREAST_Human1.40116724
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.38274048
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35692406
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35137854
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32146786
64FUS_26573619_Chip-Seq_HEK293_Human1.32076109
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.31231414
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30361482
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30175114
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27641526
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27367801
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27310579
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24242775
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22313687
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22275358
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21375083
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19085479
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.15874496
77TFEB_21752829_ChIP-Seq_HELA_Human1.14474091
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10238066
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09173366
80MYC_22102868_ChIP-Seq_BL_Human1.08844202
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08456368
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08408162
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06621688
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06506081
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06419418
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05965774
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03004705
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.00343895
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99375500
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98180506
91MYC_18940864_ChIP-ChIP_HL60_Human0.97969064
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93277537
93SPI1_23547873_ChIP-Seq_NB4_Human0.91998591
94RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90686462
95IGF1R_20145208_ChIP-Seq_DFB_Human0.90388904
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89978369
97NOTCH1_21737748_ChIP-Seq_TLL_Human0.89855646
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87533873
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86683264
100FLI1_27457419_Chip-Seq_LIVER_Mouse0.86458323
101TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86249350
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86014838
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85590303
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83572482
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79681832
106OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79491782
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78645216
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78613131
109* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.78285264
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78092673
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76322520
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.76311091
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.76037161
114VDR_21846776_ChIP-Seq_THP-1_Human0.75620499
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.75311784
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75033787
117CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73833936
118MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73070871
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72882111
120TP53_22573176_ChIP-Seq_HFKS_Human0.71594469
121CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70462625
122CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69689771
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68224651
124P300_19829295_ChIP-Seq_ESCs_Human0.62912459
125* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.62147697
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61291627
127NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.59986061
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.58555864
129CTBP2_25329375_ChIP-Seq_LNCAP_Human0.57295596
130FOXA1_27270436_Chip-Seq_PROSTATE_Human0.57096591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.86371516
2MP0010094_abnormal_chromosome_stability4.84554693
3MP0004957_abnormal_blastocyst_morpholog4.73532624
4MP0003111_abnormal_nucleus_morphology4.56325065
5MP0003077_abnormal_cell_cycle4.17439835
6MP0008057_abnormal_DNA_replication3.82728346
7MP0008058_abnormal_DNA_repair3.63461231
8MP0008932_abnormal_embryonic_tissue2.97148976
9MP0008007_abnormal_cellular_replicative2.84982895
10MP0002396_abnormal_hematopoietic_system2.49543959
11MP0003123_paternal_imprinting2.49205771
12MP0001730_embryonic_growth_arrest2.43799208
13MP0000350_abnormal_cell_proliferation2.22158860
14MP0003806_abnormal_nucleotide_metabolis2.19692751
15MP0008877_abnormal_DNA_methylation2.14523307
16MP0003718_maternal_effect2.14486344
17MP0003786_premature_aging2.06717687
18MP0006072_abnormal_retinal_apoptosis1.79084199
19MP0001697_abnormal_embryo_size1.67910082
20MP0010307_abnormal_tumor_latency1.67867550
21MP0000490_abnormal_crypts_of1.67859934
22MP0010352_gastrointestinal_tract_polyps1.66060986
23MP0009697_abnormal_copulation1.64611104
24MP0003186_abnormal_redox_activity1.62706066
25MP0001672_abnormal_embryogenesis/_devel1.60772607
26MP0005380_embryogenesis_phenotype1.60772607
27MP0002080_prenatal_lethality1.56491216
28MP0009333_abnormal_splenocyte_physiolog1.51456189
29MP0000313_abnormal_cell_death1.49770807
30MP0002019_abnormal_tumor_incidence1.47815168
31MP0002085_abnormal_embryonic_tissue1.44595329
32MP0003984_embryonic_growth_retardation1.39627805
33MP0002210_abnormal_sex_determination1.39169072
34MP0002088_abnormal_embryonic_growth/wei1.35613188
35MP0001145_abnormal_male_reproductive1.25608620
36MP0003567_abnormal_fetal_cardiomyocyte1.25566859
37MP0003315_abnormal_perineum_morphology1.25054651
38MP0002084_abnormal_developmental_patter1.24365905
39MP0001286_abnormal_eye_development1.24319326
40MP0000049_abnormal_middle_ear1.22859372
41MP0009379_abnormal_foot_pigmentation1.22605784
42MP0001929_abnormal_gametogenesis1.19328027
43MP0002132_abnormal_respiratory_system1.18600758
44MP0005397_hematopoietic_system_phenotyp1.17769770
45MP0001545_abnormal_hematopoietic_system1.17769770
46MP0002254_reproductive_system_inflammat1.17237458
47MP0010030_abnormal_orbit_morphology1.17084094
48MP0002736_abnormal_nociception_after1.17041571
49MP0001293_anophthalmia1.16753699
50MP0002086_abnormal_extraembryonic_tissu1.16346268
51MP0000631_abnormal_neuroendocrine_gland1.13280646
52MP0004197_abnormal_fetal_growth/weight/1.12329687
53MP0001485_abnormal_pinna_reflex1.11915238
54MP0001919_abnormal_reproductive_system1.10872776
55MP0003763_abnormal_thymus_physiology1.07677033
56MP0004808_abnormal_hematopoietic_stem1.06948653
57MP0002163_abnormal_gland_morphology1.06862532
58MP0005174_abnormal_tail_pigmentation1.06724607
59MP0000653_abnormal_sex_gland1.06709601
60MP0005377_hearing/vestibular/ear_phenot1.04331492
61MP0003878_abnormal_ear_physiology1.04331492
62MP0000358_abnormal_cell_content/1.04164550
63MP0000372_irregular_coat_pigmentation1.01850065
64MP0005551_abnormal_eye_electrophysiolog1.00117117
65MP0002722_abnormal_immune_system0.99426097
66MP0002398_abnormal_bone_marrow0.98730112
67MP0001346_abnormal_lacrimal_gland0.98184571
68MP0000689_abnormal_spleen_morphology0.97573927
69MP0000703_abnormal_thymus_morphology0.97245995
70MP0002751_abnormal_autonomic_nervous0.95260053
71MP0002697_abnormal_eye_size0.95246255
72MP0005253_abnormal_eye_physiology0.94647056
73MP0001529_abnormal_vocalization0.94388795
74MP0001188_hyperpigmentation0.93299069
75MP0003121_genomic_imprinting0.91612931
76MP0008789_abnormal_olfactory_epithelium0.91378270
77MP0002234_abnormal_pharynx_morphology0.89802624
78MP0002160_abnormal_reproductive_system0.88865532
79MP0006036_abnormal_mitochondrial_physio0.87371796
80MP0003938_abnormal_ear_development0.87296164
81MP0008872_abnormal_physiological_respon0.86473257
82MP0000647_abnormal_sebaceous_gland0.85501653
83MP0003755_abnormal_palate_morphology0.85355442
84MP0000858_altered_metastatic_potential0.83984364
85MP0002429_abnormal_blood_cell0.83808685
86MP0000428_abnormal_craniofacial_morphol0.83504332
87MP0005391_vision/eye_phenotype0.83475184
88MP0003787_abnormal_imprinting0.83138176
89MP0006292_abnormal_olfactory_placode0.82383350
90MP0002233_abnormal_nose_morphology0.82296152
91MP0005384_cellular_phenotype0.81795337
92MP0003861_abnormal_nervous_system0.81779447
93MP0001853_heart_inflammation0.81561519
94MP0001968_abnormal_touch/_nociception0.81332452
95MP0004133_heterotaxia0.80322370
96MP0000427_abnormal_hair_cycle0.79872729
97MP0003937_abnormal_limbs/digits/tail_de0.79785901
98MP0003195_calcinosis0.78630545
99MP0003890_abnormal_embryonic-extraembry0.77532091
100MP0003221_abnormal_cardiomyocyte_apopto0.77305824
101MP0003646_muscle_fatigue0.77199018
102MP0001119_abnormal_female_reproductive0.76772516
103MP0008995_early_reproductive_senescence0.74757401
104MP0005171_absent_coat_pigmentation0.74496389
105MP0002837_dystrophic_cardiac_calcinosis0.74361543
106MP0002111_abnormal_tail_morphology0.74035429
107MP0004147_increased_porphyrin_level0.73037058
108MP0005621_abnormal_cell_physiology0.72998355
109MP0009672_abnormal_birth_weight0.72119869
110MP0008260_abnormal_autophagy0.71824241
111MP0003136_yellow_coat_color0.71777280
112MP0003656_abnormal_erythrocyte_physiolo0.70022975
113MP0005389_reproductive_system_phenotype0.69999837
114MP0005075_abnormal_melanosome_morpholog0.69844246
115MP0006054_spinal_hemorrhage0.69608243
116MP0002653_abnormal_ependyma_morphology0.68322197
117MP0000716_abnormal_immune_system0.68234899
118MP0003119_abnormal_digestive_system0.66926603
119MP0003941_abnormal_skin_development0.66892643
120MP0005195_abnormal_posterior_eye0.66602414
121MP0002102_abnormal_ear_morphology0.66502350
122MP0006035_abnormal_mitochondrial_morpho0.64893285
123MP0000566_synostosis0.63941300
124MP0001915_intracranial_hemorrhage0.63793414
125MP0000537_abnormal_urethra_morphology0.63214614
126MP0009840_abnormal_foam_cell0.62870309
127MP0005023_abnormal_wound_healing0.62237207
128MP0003698_abnormal_male_reproductive0.61603251
129MP0002938_white_spotting0.61409459
130MP0003950_abnormal_plasma_membrane0.60520426
131MP0005395_other_phenotype0.59648040
132MP0002095_abnormal_skin_pigmentation0.59262798
133MP0000477_abnormal_intestine_morphology0.58823062
134MP0001727_abnormal_embryo_implantation0.58622703
135MP0002405_respiratory_system_inflammati0.58610706
136MP0002092_abnormal_eye_morphology0.58345897
137MP0002161_abnormal_fertility/fecundity0.57030664
138MP0003448_altered_tumor_morphology0.54629056
139MP0005266_abnormal_metabolism0.54295804
140MP0002420_abnormal_adaptive_immunity0.51698678
141MP0000685_abnormal_immune_system0.51534543
142MP0003699_abnormal_female_reproductive0.50630818

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.63578200
2Breast hypoplasia (HP:0003187)4.76866667
3Reticulocytopenia (HP:0001896)4.64727614
4Abnormality of cells of the erythroid lineage (HP:0012130)4.57457512
5Abnormal number of erythroid precursors (HP:0012131)4.35947901
6Cerebral hypomyelination (HP:0006808)4.23336107
7Oral leukoplakia (HP:0002745)3.78334296
8Carpal bone hypoplasia (HP:0001498)3.65754878
9Chromsome breakage (HP:0040012)3.53806165
10Macrocytic anemia (HP:0001972)3.48499827
11Colon cancer (HP:0003003)3.47830522
12Rough bone trabeculation (HP:0100670)3.39958600
13Patellar aplasia (HP:0006443)3.29694884
14Aplastic anemia (HP:0001915)3.19775415
15Aplasia/Hypoplasia of the patella (HP:0006498)3.18781679
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.13249784
17Selective tooth agenesis (HP:0001592)3.09936507
18Abnormality of the anterior horn cell (HP:0006802)3.02805793
19Degeneration of anterior horn cells (HP:0002398)3.02805793
20Meckel diverticulum (HP:0002245)3.00231928
21Pallor (HP:0000980)2.95962879
22Abnormality of chromosome stability (HP:0003220)2.93293374
23Septo-optic dysplasia (HP:0100842)2.88775727
24Abnormality of the preputium (HP:0100587)2.86471705
25Abnormality of the ileum (HP:0001549)2.82889726
26Absent radius (HP:0003974)2.80789561
27Agnosia (HP:0010524)2.76280941
28Absent thumb (HP:0009777)2.73407532
29Medulloblastoma (HP:0002885)2.71094245
30Abnormality of the carotid arteries (HP:0005344)2.69742463
31Premature graying of hair (HP:0002216)2.69315382
32Microretrognathia (HP:0000308)2.69281887
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61002667
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61002667
35Aplasia involving forearm bones (HP:0009822)2.59302997
36Absent forearm bone (HP:0003953)2.59302997
37Multiple enchondromatosis (HP:0005701)2.57774170
38CNS hypomyelination (HP:0003429)2.57109370
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.57059522
40Impulsivity (HP:0100710)2.56579640
41Pancreatic cysts (HP:0001737)2.54738396
42Neoplasm of the pancreas (HP:0002894)2.51449734
43Abnormal trabecular bone morphology (HP:0100671)2.50925208
44Secondary amenorrhea (HP:0000869)2.50610284
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.50540543
46Aplasia/Hypoplasia of the uvula (HP:0010293)2.49443633
47Trismus (HP:0000211)2.49286633
48Pancreatic fibrosis (HP:0100732)2.46407262
49Supernumerary spleens (HP:0009799)2.43473137
50Horseshoe kidney (HP:0000085)2.42477393
51Pendular nystagmus (HP:0012043)2.42448006
52Duodenal stenosis (HP:0100867)2.40819224
53Small intestinal stenosis (HP:0012848)2.40819224
54Abnormal lung lobation (HP:0002101)2.39826984
55Bone marrow hypocellularity (HP:0005528)2.39701188
56Myelodysplasia (HP:0002863)2.35071976
57Clubbing of toes (HP:0100760)2.34826298
58Hypoplasia of the pons (HP:0012110)2.29853489
59Triphalangeal thumb (HP:0001199)2.29395508
60Abnormality of midbrain morphology (HP:0002418)2.29303785
61Molar tooth sign on MRI (HP:0002419)2.29303785
62Absent septum pellucidum (HP:0001331)2.25035888
63True hermaphroditism (HP:0010459)2.25021754
64Ependymoma (HP:0002888)2.24339336
65Acute necrotizing encephalopathy (HP:0006965)2.24102566
66Premature ovarian failure (HP:0008209)2.23589728
67Abnormality of the pons (HP:0007361)2.23587794
68Bilateral microphthalmos (HP:0007633)2.23477638
69Sloping forehead (HP:0000340)2.22659625
70Abnormality of cochlea (HP:0000375)2.20075181
71Pancytopenia (HP:0001876)2.18234204
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16992980
73Rhabdomyosarcoma (HP:0002859)2.16971397
74Abnormality of the labia minora (HP:0012880)2.16064477
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15024964
76Acute encephalopathy (HP:0006846)2.14157086
77Cellular immunodeficiency (HP:0005374)2.13592870
78Increased CSF lactate (HP:0002490)2.13040826
79Megaloblastic anemia (HP:0001889)2.10169535
80Cleft eyelid (HP:0000625)2.10083674
81Mitochondrial inheritance (HP:0001427)2.09479967
82Atresia of the external auditory canal (HP:0000413)2.09290361
83Optic nerve hypoplasia (HP:0000609)2.09107834
84Abnormality of the umbilical cord (HP:0010881)2.08998451
85Postnatal microcephaly (HP:0005484)2.08950763
86Increased serum lactate (HP:0002151)2.08872794
87Tracheoesophageal fistula (HP:0002575)2.06742781
88Abnormal spermatogenesis (HP:0008669)2.06177478
89Abnormality of the septum pellucidum (HP:0007375)2.05620407
90Sclerocornea (HP:0000647)2.04711617
91Duplicated collecting system (HP:0000081)2.02344350
92Abnormality of glycolysis (HP:0004366)2.01862593
93Increased serum pyruvate (HP:0003542)2.01862593
94Basal cell carcinoma (HP:0002671)2.01110290
95Poor head control (HP:0002421)2.00742853
96Ectopic kidney (HP:0000086)1.99991048
97Lipid accumulation in hepatocytes (HP:0006561)1.99702121
98Personality changes (HP:0000751)1.99223181
99Congenital stationary night blindness (HP:0007642)1.99153833
10011 pairs of ribs (HP:0000878)1.98273077
101Type I transferrin isoform profile (HP:0003642)1.98057341
102Exertional dyspnea (HP:0002875)1.96097381
103Abnormality of DNA repair (HP:0003254)1.96023534
104Sparse eyelashes (HP:0000653)1.95726860
105Thrombocytosis (HP:0001894)1.95160858
106Abnormal number of incisors (HP:0011064)1.94190330
107Abnormality of the duodenum (HP:0002246)1.93196655
108Stenosis of the external auditory canal (HP:0000402)1.91676391
109Abnormal mitochondria in muscle tissue (HP:0008316)1.91452031
110Hypoplasia of the radius (HP:0002984)1.90774668
111Lymphoma (HP:0002665)1.90756490
112Nephroblastoma (Wilms tumor) (HP:0002667)1.88958304
113Nephronophthisis (HP:0000090)1.88891045
114Morphological abnormality of the inner ear (HP:0011390)1.88766911
115Asplenia (HP:0001746)1.88761180
116Small hand (HP:0200055)1.88280578
117Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88270645
118Slender long bone (HP:0003100)1.88198747
119Abnormality of the heme biosynthetic pathway (HP:0010472)1.85127317
120Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84157701
121Increased hepatocellular lipid droplets (HP:0006565)1.83563248
122Ureteral duplication (HP:0000073)1.83321966
123Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83225497
124Abnormality of alanine metabolism (HP:0010916)1.83225497
125Hyperalaninemia (HP:0003348)1.83225497
126Glossoptosis (HP:0000162)1.80832834
127Volvulus (HP:0002580)1.79254845
128Hepatocellular necrosis (HP:0001404)1.78981473
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.78277865
130Short thumb (HP:0009778)1.77598569
131Neoplasm of the colon (HP:0100273)1.77360770
132Abnormality of the renal collecting system (HP:0004742)1.76998812
133Partial agenesis of the corpus callosum (HP:0001338)1.76436171
134Aplasia/Hypoplasia involving the musculature (HP:0001460)1.75819373
135Single umbilical artery (HP:0001195)1.75664868
136Progressive macrocephaly (HP:0004481)1.75319514
137Embryonal renal neoplasm (HP:0011794)1.75228523
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.75164186
139Glioma (HP:0009733)1.74630874
140Facial cleft (HP:0002006)1.74234667
141Congenital, generalized hypertrichosis (HP:0004540)1.73973783
142Preaxial hand polydactyly (HP:0001177)1.73647806
143Anophthalmia (HP:0000528)1.72827566
144Dandy-Walker malformation (HP:0001305)1.69485069
145Methylmalonic acidemia (HP:0002912)1.65831684
146Type II lissencephaly (HP:0007260)1.64756051
147Holoprosencephaly (HP:0001360)1.63985475
148Hyperglycinemia (HP:0002154)1.60854839
149Hyperglycinuria (HP:0003108)1.60560731
150Methylmalonic aciduria (HP:0012120)1.58239325
151Abnormality of homocysteine metabolism (HP:0010919)1.57649260
152Homocystinuria (HP:0002156)1.57649260
153Abnormality of serum amino acid levels (HP:0003112)1.57040332

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.28522899
2WEE14.67857865
3CDC74.00012514
4EIF2AK13.50510449
5VRK23.48087933
6NME22.75168235
7STK162.63402416
8NEK22.63152662
9TAF12.51517163
10PLK42.50079519
11TESK22.48545500
12SRPK12.37709606
13NUAK12.20920218
14TTK2.18508283
15TLK12.13684734
16EIF2AK32.04402389
17BMPR1B1.97657811
18BRSK21.96749119
19PLK11.96396621
20DYRK31.95901907
21TSSK61.91216895
22VRK11.88129630
23ACVR1B1.86786245
24NEK11.84431735
25AURKB1.59819272
26CDK71.57945861
27PASK1.56858071
28SCYL21.56743813
29PBK1.53203139
30ATR1.47600067
31MKNK11.43728179
32FRK1.40919827
33RPS6KB21.38715608
34TNIK1.37875345
35CHEK21.35654544
36AURKA1.35446993
37PLK31.34142976
38EPHA21.33680044
39MAP3K81.32972630
40WNK31.31028495
41TRIM281.30634939
42RPS6KA41.27548335
43PIM21.16214532
44BRSK11.12993580
45STK41.12600387
46GRK11.11856363
47CDK41.11276546
48ADRBK21.09812914
49TESK11.04276138
50PAK41.03476222
51BCKDK1.03348835
52KDR1.03342289
53CHEK11.03023523
54ZAK1.02171680
55CCNB11.00808096
56MAP4K20.97443234
57STK100.96844239
58PNCK0.93898364
59BRAF0.87080747
60WNK40.83154048
61TGFBR10.81401677
62CASK0.80515196
63PLK20.78056078
64MST40.76236079
65MKNK20.75448042
66PAK10.75184571
67CDK190.75161893
68DYRK20.74425991
69RPS6KA50.73623988
70CSNK2A20.72617452
71ATM0.72047592
72CSNK2A10.70665776
73CDK80.70282785
74ERBB40.68763035
75INSRR0.68608980
76CDK20.68083777
77CSNK1G20.68068100
78PIM10.66685668
79MAP3K110.61297603
80LRRK20.60863885
81CSNK1A1L0.60814042
82FLT30.59496670
83LIMK10.58949009
84MAP4K10.58357299
85CDK120.56756662
86OXSR10.56141353
87EIF2AK20.54285173
88ABL20.53958053
89NME10.52106904
90MELK0.52071737
91BLK0.50375053
92CDK10.49874438
93MAPKAPK50.46213623
94CSNK1G30.44520082
95PRKCI0.43669834
96TAOK20.42842023
97PRKDC0.41198299
98MAPKAPK30.39028353
99ARAF0.38939263
100IRAK40.38828598
101MAP2K30.38746967
102EEF2K0.37799335
103MAP3K40.37483048
104PDK30.36811501
105PDK40.36811501
106TEC0.34944452
107CDK30.34414780
108CLK10.32971567
109ALK0.32716849
110MAP2K70.32298168
111ILK0.32021527
112MAP3K90.30862281
113FGFR10.30641487
114PDK20.30628492
115MAP3K100.30303512
116NEK90.29880357
117STK390.29687242
118CSNK1D0.29281332
119NLK0.29280477
120CSNK1G10.27959982
121CDK60.27733972
122STK30.27669509
123BCR0.27535542
124PRKCG0.26937680
125CSNK1E0.26651478
126MAP2K20.25541973
127TYK20.24878871
128FGFR20.24689422
129MAPK130.24532619
130STK38L0.24419950
131ZAP700.24395688
132CSNK1A10.23805285
133SMG10.22633773
134GRK60.21622075

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.92548098
2Mismatch repair_Homo sapiens_hsa034304.14526316
3Proteasome_Homo sapiens_hsa030503.85434925
4Ribosome_Homo sapiens_hsa030103.79841052
5RNA polymerase_Homo sapiens_hsa030203.61707219
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.47222088
7Homologous recombination_Homo sapiens_hsa034403.26934047
8Spliceosome_Homo sapiens_hsa030403.06794107
9Base excision repair_Homo sapiens_hsa034103.00495113
10RNA transport_Homo sapiens_hsa030132.85656168
11Nucleotide excision repair_Homo sapiens_hsa034202.84601920
12Pyrimidine metabolism_Homo sapiens_hsa002402.68944149
13Cell cycle_Homo sapiens_hsa041102.52239590
14One carbon pool by folate_Homo sapiens_hsa006702.33744176
15Non-homologous end-joining_Homo sapiens_hsa034502.28512907
16Basal transcription factors_Homo sapiens_hsa030222.04873289
17Fanconi anemia pathway_Homo sapiens_hsa034602.04410381
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97018656
19RNA degradation_Homo sapiens_hsa030181.76082416
20Vitamin B6 metabolism_Homo sapiens_hsa007501.67234662
21p53 signaling pathway_Homo sapiens_hsa041151.47867207
22Purine metabolism_Homo sapiens_hsa002301.44037330
23mRNA surveillance pathway_Homo sapiens_hsa030151.27822867
24Systemic lupus erythematosus_Homo sapiens_hsa053221.25303811
25Folate biosynthesis_Homo sapiens_hsa007901.24394649
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22952119
27Protein export_Homo sapiens_hsa030601.21591323
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19405493
29Epstein-Barr virus infection_Homo sapiens_hsa051691.14170340
30Phototransduction_Homo sapiens_hsa047441.11512853
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.08270701
32Propanoate metabolism_Homo sapiens_hsa006401.01383928
33Pentose phosphate pathway_Homo sapiens_hsa000300.97250089
34Sulfur relay system_Homo sapiens_hsa041220.96146312
35Pyruvate metabolism_Homo sapiens_hsa006200.91688535
36Huntingtons disease_Homo sapiens_hsa050160.88310110
37Glutathione metabolism_Homo sapiens_hsa004800.87926220
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85489576
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84324509
40Drug metabolism - other enzymes_Homo sapiens_hsa009830.82254913
41Parkinsons disease_Homo sapiens_hsa050120.82163475
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82069781
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81641339
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81078165
45Oocyte meiosis_Homo sapiens_hsa041140.80996074
46Nitrogen metabolism_Homo sapiens_hsa009100.80322427
47Antigen processing and presentation_Homo sapiens_hsa046120.79930000
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79856591
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79099724
50Biosynthesis of amino acids_Homo sapiens_hsa012300.78993597
51Viral carcinogenesis_Homo sapiens_hsa052030.78807691
52Herpes simplex infection_Homo sapiens_hsa051680.73433737
53Oxidative phosphorylation_Homo sapiens_hsa001900.69573245
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.65905698
55Tryptophan metabolism_Homo sapiens_hsa003800.65413596
56Butanoate metabolism_Homo sapiens_hsa006500.65059582
57Selenocompound metabolism_Homo sapiens_hsa004500.63689462
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62946894
59Hedgehog signaling pathway_Homo sapiens_hsa043400.61859349
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60959896
61Lysine degradation_Homo sapiens_hsa003100.58233387
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57758141
63Fatty acid elongation_Homo sapiens_hsa000620.56695071
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54667549
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54609494
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54421184
67Cardiac muscle contraction_Homo sapiens_hsa042600.54073244
68HTLV-I infection_Homo sapiens_hsa051660.52110332
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50084465
70Carbon metabolism_Homo sapiens_hsa012000.49778761
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49158729
72Primary immunodeficiency_Homo sapiens_hsa053400.45467417
73Caffeine metabolism_Homo sapiens_hsa002320.42711943
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.42605216
75Sulfur metabolism_Homo sapiens_hsa009200.40594131
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38923446
77Metabolic pathways_Homo sapiens_hsa011000.38830073
78Thyroid cancer_Homo sapiens_hsa052160.36885739
79Vitamin digestion and absorption_Homo sapiens_hsa049770.36234464
80Legionellosis_Homo sapiens_hsa051340.35213109
81Regulation of autophagy_Homo sapiens_hsa041400.34718956
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34591057
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34314204
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33992546
85Shigellosis_Homo sapiens_hsa051310.32758485
86Alcoholism_Homo sapiens_hsa050340.31649664
87Small cell lung cancer_Homo sapiens_hsa052220.31160811
88Arachidonic acid metabolism_Homo sapiens_hsa005900.31065240
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30564432
90Wnt signaling pathway_Homo sapiens_hsa043100.29372763
91Apoptosis_Homo sapiens_hsa042100.29357302
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28927860
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28050704
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27513830
95Peroxisome_Homo sapiens_hsa041460.26841527
96N-Glycan biosynthesis_Homo sapiens_hsa005100.26340281
97Arginine and proline metabolism_Homo sapiens_hsa003300.25027938
98MicroRNAs in cancer_Homo sapiens_hsa052060.24623049
99Fructose and mannose metabolism_Homo sapiens_hsa000510.24470461
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23455956
101Linoleic acid metabolism_Homo sapiens_hsa005910.23423817
102TGF-beta signaling pathway_Homo sapiens_hsa043500.21565145
103Taste transduction_Homo sapiens_hsa047420.21208624
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21025467
105beta-Alanine metabolism_Homo sapiens_hsa004100.20944680
106Alzheimers disease_Homo sapiens_hsa050100.20561881
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20295578
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19604360
109Steroid biosynthesis_Homo sapiens_hsa001000.19236605
110Olfactory transduction_Homo sapiens_hsa047400.19142256
111Measles_Homo sapiens_hsa051620.18804147
112Fatty acid metabolism_Homo sapiens_hsa012120.16724959
113Hippo signaling pathway_Homo sapiens_hsa043900.16417335
114Renin-angiotensin system_Homo sapiens_hsa046140.15243553
115Hepatitis B_Homo sapiens_hsa051610.14451450
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.12012108
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11532796
118Hematopoietic cell lineage_Homo sapiens_hsa046400.11434293
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.11300640
120Other glycan degradation_Homo sapiens_hsa005110.11001759
121Bladder cancer_Homo sapiens_hsa052190.10894707
122Colorectal cancer_Homo sapiens_hsa052100.10121803
123Galactose metabolism_Homo sapiens_hsa000520.09712065
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07473081
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07201708
126Allograft rejection_Homo sapiens_hsa053300.07029238
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06893442
128Basal cell carcinoma_Homo sapiens_hsa052170.06418673
129Pathways in cancer_Homo sapiens_hsa052000.05858961
130NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04776577
131Ether lipid metabolism_Homo sapiens_hsa005650.04210563

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