GINS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1 (GINS1; MIM 610608), Psf2, and Psf3 (GINS3; MIM 610610). The formation of this complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.90938666
2viral transcription (GO:0019083)5.29019675
3translational termination (GO:0006415)5.14495068
4* DNA strand elongation involved in DNA replication (GO:0006271)5.08230529
5telomere maintenance via semi-conservative replication (GO:0032201)5.06349497
6* DNA strand elongation (GO:0022616)4.83633891
7ribosomal small subunit biogenesis (GO:0042274)4.74300761
8DNA replication initiation (GO:0006270)4.60894633
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.57763094
10telomere maintenance via recombination (GO:0000722)4.55420316
11maturation of SSU-rRNA (GO:0030490)4.52292722
12translational elongation (GO:0006414)4.50809034
13protein targeting to ER (GO:0045047)4.47337458
14cotranslational protein targeting to membrane (GO:0006613)4.46774805
15DNA unwinding involved in DNA replication (GO:0006268)4.39443118
16mitotic recombination (GO:0006312)4.35787410
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.23770188
18nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.22830896
19DNA deamination (GO:0045006)4.21315690
20protein localization to endoplasmic reticulum (GO:0070972)4.16987431
21translational initiation (GO:0006413)4.13986437
22DNA replication checkpoint (GO:0000076)4.09925062
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04228212
24telomere maintenance via telomere lengthening (GO:0010833)4.04023977
25viral life cycle (GO:0019058)4.02441822
26cellular protein complex disassembly (GO:0043624)3.98115951
27establishment of integrated proviral latency (GO:0075713)3.95984468
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.93575567
29ribosomal large subunit biogenesis (GO:0042273)3.92661269
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.91395119
31CENP-A containing nucleosome assembly (GO:0034080)3.84700169
32chromatin remodeling at centromere (GO:0031055)3.83013370
33mitotic sister chromatid segregation (GO:0000070)3.68462365
34protein complex disassembly (GO:0043241)3.67510197
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.59563452
36formation of translation preinitiation complex (GO:0001731)3.57096900
37protein localization to kinetochore (GO:0034501)3.55318389
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.53514527
39mitotic metaphase plate congression (GO:0007080)3.53129726
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.52734093
41DNA replication-independent nucleosome assembly (GO:0006336)3.51688647
42DNA replication-independent nucleosome organization (GO:0034724)3.51688647
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51497918
44macromolecular complex disassembly (GO:0032984)3.46965261
45ATP synthesis coupled proton transport (GO:0015986)3.46773785
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46773785
47regulation of mitochondrial translation (GO:0070129)3.46344474
48chaperone-mediated protein transport (GO:0072321)3.43967275
49kinetochore organization (GO:0051383)3.41204339
50ribonucleoprotein complex biogenesis (GO:0022613)3.41013638
51nuclear-transcribed mRNA catabolic process (GO:0000956)3.39525382
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.39266270
53somatic diversification of immune receptors via somatic mutation (GO:0002566)3.39266270
54protein localization to chromosome, centromeric region (GO:0071459)3.37708214
55replication fork processing (GO:0031297)3.36707334
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34092128
57negative regulation of ligase activity (GO:0051352)3.34092128
58protein K6-linked ubiquitination (GO:0085020)3.32790891
59spliceosomal snRNP assembly (GO:0000387)3.31315717
60sister chromatid segregation (GO:0000819)3.30626757
61viral mRNA export from host cell nucleus (GO:0046784)3.30490267
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29550230
63negative regulation of RNA splicing (GO:0033119)3.28337221
64translation (GO:0006412)3.26648159
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24388625
66DNA catabolic process, exonucleolytic (GO:0000738)3.23524026
67mRNA catabolic process (GO:0006402)3.23356107
68transcription-coupled nucleotide-excision repair (GO:0006283)3.22982261
69nucleobase biosynthetic process (GO:0046112)3.22663488
70base-excision repair (GO:0006284)3.22442630
71spliceosomal complex assembly (GO:0000245)3.21447269
72cell cycle G1/S phase transition (GO:0044843)3.20345981
73G1/S transition of mitotic cell cycle (GO:0000082)3.20345981
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.19803904
75kinetochore assembly (GO:0051382)3.19698243
76RNA catabolic process (GO:0006401)3.19185974
77metaphase plate congression (GO:0051310)3.18678317
78pseudouridine synthesis (GO:0001522)3.18009877
79rRNA processing (GO:0006364)3.15556695
80postreplication repair (GO:0006301)3.14597869
81attachment of spindle microtubules to kinetochore (GO:0008608)3.13172372
82IMP biosynthetic process (GO:0006188)3.12893022
83negative regulation of DNA-dependent DNA replication (GO:2000104)3.10792381
84rRNA modification (GO:0000154)3.06955197
85DNA double-strand break processing (GO:0000729)3.05660843
86cullin deneddylation (GO:0010388)3.05653891
87DNA replication-dependent nucleosome organization (GO:0034723)3.05253385
88DNA replication-dependent nucleosome assembly (GO:0006335)3.05253385
89rRNA metabolic process (GO:0016072)3.04752547
90regulation of mitotic spindle checkpoint (GO:1903504)3.03497402
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03497402
92telomere maintenance (GO:0000723)3.03431789
93spindle checkpoint (GO:0031577)3.03091638
94DNA strand renaturation (GO:0000733)3.01774603
95telomere organization (GO:0032200)3.01586456
96histone exchange (GO:0043486)3.01478296
97regulation of centriole replication (GO:0046599)3.01262057
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00624177
99double-strand break repair via nonhomologous end joining (GO:0006303)3.00379102
100non-recombinational repair (GO:0000726)3.00379102
101mitotic nuclear envelope disassembly (GO:0007077)2.99993126
102ATP-dependent chromatin remodeling (GO:0043044)2.99846539
103regulation of nuclear cell cycle DNA replication (GO:0033262)2.97862680
104negative regulation of chromosome segregation (GO:0051985)2.97621159
105L-serine metabolic process (GO:0006563)2.96585384
106establishment of viral latency (GO:0019043)2.96101154
107heterochromatin organization (GO:0070828)2.95359366
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.95330622
109negative regulation of sister chromatid segregation (GO:0033046)2.95330622
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.95330622
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.95330622
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.95330622
113establishment of chromosome localization (GO:0051303)2.94396028
114DNA damage response, detection of DNA damage (GO:0042769)2.93947434
115proteasome assembly (GO:0043248)2.93276762
116mismatch repair (GO:0006298)2.92135319
117termination of RNA polymerase II transcription (GO:0006369)2.91916757
118purine nucleobase biosynthetic process (GO:0009113)2.91372404
1193-UTR-mediated mRNA stabilization (GO:0070935)2.90415783
120nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90207210
121RNA splicing, via transesterification reactions (GO:0000375)2.87567942
122mRNA splicing, via spliceosome (GO:0000398)2.87260621
123RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.87260621
124DNA ligation (GO:0006266)2.87190793
125histone H2A acetylation (GO:0043968)2.84502013
126tRNA methylation (GO:0030488)2.83876857
127negative regulation of mRNA processing (GO:0050686)2.83486419
128mitotic chromosome condensation (GO:0007076)2.83075765
129folic acid-containing compound biosynthetic process (GO:0009396)2.80866477
130mitotic sister chromatid cohesion (GO:0007064)2.80593187
131transcription elongation from RNA polymerase III promoter (GO:0006385)2.79928403
132termination of RNA polymerase III transcription (GO:0006386)2.79928403
133translesion synthesis (GO:0019985)2.78910065
134protein targeting to membrane (GO:0006612)2.77439737
135somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75959328
136isotype switching (GO:0045190)2.75959328
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75959328
138chromatin assembly or disassembly (GO:0006333)2.74781490
139deoxyribonucleotide biosynthetic process (GO:0009263)2.74227825
140IMP metabolic process (GO:0046040)2.73604850
141regulation of double-strand break repair via homologous recombination (GO:0010569)2.73037859
142ribosome biogenesis (GO:0042254)2.71753878
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71659775
144DNA duplex unwinding (GO:0032508)2.70119606

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.26003492
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.35121023
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.72625412
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71573045
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.69064986
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27178844
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25859852
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.19852407
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02424347
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95349297
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.88217417
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.87353161
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81705796
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.81369582
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.72266018
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68699774
17XRN2_22483619_ChIP-Seq_HELA_Human2.52403791
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49966695
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39520268
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37623423
21VDR_23849224_ChIP-Seq_CD4+_Human2.20992832
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16900468
23FOXP3_21729870_ChIP-Seq_TREG_Human2.14062879
24* E2F1_21310950_ChIP-Seq_MCF-7_Human2.12317881
25TTF2_22483619_ChIP-Seq_HELA_Human2.03489577
26DCP1A_22483619_ChIP-Seq_HELA_Human2.00347675
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99290798
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98471154
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98353014
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95214849
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91042481
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89161606
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.87245158
34CIITA_25753668_ChIP-Seq_RAJI_Human1.84271995
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81451705
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.77559485
37AR_21909140_ChIP-Seq_LNCAP_Human1.77137312
38GABP_19822575_ChIP-Seq_HepG2_Human1.76981955
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76661594
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.75914462
41MYC_22102868_ChIP-Seq_BL_Human1.72549573
42ELK1_19687146_ChIP-ChIP_HELA_Human1.70157144
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68105884
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63368300
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61955071
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59611543
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58095731
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54908939
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54587330
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53407094
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51151226
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50019189
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49973845
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.49057482
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47341612
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44163301
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.41894173
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40441092
59VDR_21846776_ChIP-Seq_THP-1_Human1.40302861
60KDM5A_27292631_Chip-Seq_BREAST_Human1.35040161
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.30711090
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29411268
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.26337631
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25049867
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24331910
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22814940
67SALL1_21062744_ChIP-ChIP_HESCs_Human1.20577555
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20217858
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18718468
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16528515
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15279446
72* MYC_18940864_ChIP-ChIP_HL60_Human1.13576727
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13262889
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12548075
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11609295
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11167320
77SPI1_23547873_ChIP-Seq_NB4_Human1.10669028
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08951529
79IRF1_19129219_ChIP-ChIP_H3396_Human1.08620352
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.05460299
81SCL_19346495_ChIP-Seq_HPC-7_Human1.04223854
82SOX2_16153702_ChIP-ChIP_HESCs_Human1.01959862
83E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01859828
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00667349
85ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99749504
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99517715
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98371750
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.96814124
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96140186
90PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95988752
91TFEB_21752829_ChIP-Seq_HELA_Human0.95420668
92KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95277870
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94688706
94DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94584615
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93743166
96EWS_26573619_Chip-Seq_HEK293_Human0.93165054
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91755480
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88103743
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80133189
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.79905080
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79398368
102IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78331878
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.78211978
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77830900
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77020981
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75811820
107* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74693973
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.73837029
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73504614
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73250661
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.72436082
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.72074615
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67456503
114* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64493722
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.62220705
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.60169994
117FOXP1_21924763_ChIP-Seq_HESCs_Human0.59841772
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.59671740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.36787133
2MP0010094_abnormal_chromosome_stability4.29424284
3MP0008057_abnormal_DNA_replication3.80175206
4MP0004957_abnormal_blastocyst_morpholog3.71852718
5MP0003111_abnormal_nucleus_morphology3.65292748
6MP0003077_abnormal_cell_cycle3.40422748
7MP0008058_abnormal_DNA_repair3.08137844
8MP0008007_abnormal_cellular_replicative3.00646806
9MP0002396_abnormal_hematopoietic_system2.44911381
10MP0008932_abnormal_embryonic_tissue2.42920159
11MP0006292_abnormal_olfactory_placode2.22238936
12MP0003786_premature_aging2.16578324
13MP0009379_abnormal_foot_pigmentation2.10770711
14MP0003315_abnormal_perineum_morphology2.09755514
15MP0003123_paternal_imprinting2.08825476
16MP0004808_abnormal_hematopoietic_stem2.08499122
17MP0010030_abnormal_orbit_morphology2.06866934
18MP0000490_abnormal_crypts_of1.96389200
19MP0008877_abnormal_DNA_methylation1.85817025
20MP0000350_abnormal_cell_proliferation1.84338427
21MP0003806_abnormal_nucleotide_metabolis1.81832143
22MP0003121_genomic_imprinting1.72412666
23MP0001730_embryonic_growth_arrest1.69149356
24MP0009697_abnormal_copulation1.67361901
25MP0003136_yellow_coat_color1.61560273
26MP0009333_abnormal_splenocyte_physiolog1.47105192
27MP0000313_abnormal_cell_death1.44039875
28MP0005397_hematopoietic_system_phenotyp1.43169489
29MP0001545_abnormal_hematopoietic_system1.43169489
30MP0001346_abnormal_lacrimal_gland1.42386714
31MP0006035_abnormal_mitochondrial_morpho1.37447074
32MP0001697_abnormal_embryo_size1.36332464
33MP0001293_anophthalmia1.35161998
34MP0003186_abnormal_redox_activity1.34791414
35MP0003763_abnormal_thymus_physiology1.32743657
36MP0010307_abnormal_tumor_latency1.32202088
37MP0000372_irregular_coat_pigmentation1.27949058
38MP0002019_abnormal_tumor_incidence1.27639602
39MP0005380_embryogenesis_phenotype1.27624334
40MP0001672_abnormal_embryogenesis/_devel1.27624334
41MP0006036_abnormal_mitochondrial_physio1.25783449
42MP0001529_abnormal_vocalization1.24623170
43MP0002085_abnormal_embryonic_tissue1.23600402
44MP0002080_prenatal_lethality1.23458876
45MP0002234_abnormal_pharynx_morphology1.23325668
46MP0004133_heterotaxia1.23312726
47MP0010352_gastrointestinal_tract_polyps1.23240332
48MP0005174_abnormal_tail_pigmentation1.22690348
49MP0004197_abnormal_fetal_growth/weight/1.21182882
50MP0008789_abnormal_olfactory_epithelium1.20596546
51MP0000566_synostosis1.18903589
52MP0002398_abnormal_bone_marrow1.18418095
53MP0000703_abnormal_thymus_morphology1.17722346
54MP0003567_abnormal_fetal_cardiomyocyte1.16695236
55MP0003941_abnormal_skin_development1.14586433
56MP0008995_early_reproductive_senescence1.14317830
57MP0002938_white_spotting1.12851666
58MP0006054_spinal_hemorrhage1.12704308
59MP0002084_abnormal_developmental_patter1.12445447
60MP0000049_abnormal_middle_ear1.12199244
61MP0003984_embryonic_growth_retardation1.11685123
62MP0002751_abnormal_autonomic_nervous1.08738614
63MP0002088_abnormal_embryonic_growth/wei1.07995716
64MP0009672_abnormal_birth_weight1.07666853
65MP0002210_abnormal_sex_determination1.06655466
66MP0002697_abnormal_eye_size1.06617115
67MP0000858_altered_metastatic_potential1.04228357
68MP0002722_abnormal_immune_system1.02707517
69MP0002102_abnormal_ear_morphology1.02452851
70MP0002233_abnormal_nose_morphology1.01730458
71MP0000689_abnormal_spleen_morphology1.01451279
72MP0003119_abnormal_digestive_system0.98487431
73MP0002086_abnormal_extraembryonic_tissu0.94779723
74MP0002877_abnormal_melanocyte_morpholog0.93187550
75MP0005075_abnormal_melanosome_morpholog0.92892660
76MP0002095_abnormal_skin_pigmentation0.92319161
77MP0001145_abnormal_male_reproductive0.92298429
78MP0002160_abnormal_reproductive_system0.91502049
79MP0003787_abnormal_imprinting0.91176039
80MP0000358_abnormal_cell_content/0.90702502
81MP0002429_abnormal_blood_cell0.89382620
82MP0000537_abnormal_urethra_morphology0.89087533
83MP0003890_abnormal_embryonic-extraembry0.89031254
84MP0009053_abnormal_anal_canal0.88034163
85MP0001286_abnormal_eye_development0.87209095
86MP0002009_preneoplasia0.86548391
87MP0004147_increased_porphyrin_level0.85829110
88MP0005408_hypopigmentation0.83822560
89MP0002736_abnormal_nociception_after0.83252728
90MP0003698_abnormal_male_reproductive0.82110520
91MP0003937_abnormal_limbs/digits/tail_de0.82088746
92MP0002932_abnormal_joint_morphology0.81752141
93MP0005395_other_phenotype0.80021051
94MP0005367_renal/urinary_system_phenotyp0.79751317
95MP0000516_abnormal_urinary_system0.79751317
96MP0001119_abnormal_female_reproductive0.79152185
97MP0003718_maternal_effect0.78368916
98MP0000653_abnormal_sex_gland0.78109925
99MP0000678_abnormal_parathyroid_gland0.77233051
100MP0000716_abnormal_immune_system0.76984932
101MP0000631_abnormal_neuroendocrine_gland0.76188814
102MP0002161_abnormal_fertility/fecundity0.75957648
103MP0006072_abnormal_retinal_apoptosis0.75283754
104MP0003699_abnormal_female_reproductive0.74951209
105MP0001929_abnormal_gametogenesis0.74854585
106MP0005389_reproductive_system_phenotype0.74668853
107MP0009278_abnormal_bone_marrow0.71999458
108MP0003943_abnormal_hepatobiliary_system0.71376709
109MP0003755_abnormal_palate_morphology0.70848069
110MP0000428_abnormal_craniofacial_morphol0.70499803
111MP0002092_abnormal_eye_morphology0.70283879
112MP0003861_abnormal_nervous_system0.68591298
113MP0000477_abnormal_intestine_morphology0.68232673
114MP0002111_abnormal_tail_morphology0.67305516
115MP0002163_abnormal_gland_morphology0.67092180
116MP0001764_abnormal_homeostasis0.65891600
117MP0000465_gastrointestinal_hemorrhage0.65049257
118MP0001919_abnormal_reproductive_system0.64938156
119MP0001186_pigmentation_phenotype0.64913199
120MP0000685_abnormal_immune_system0.64908732
121MP0005391_vision/eye_phenotype0.64673228
122MP0002075_abnormal_coat/hair_pigmentati0.64534420
123MP0000015_abnormal_ear_pigmentation0.63580073
124MP0005394_taste/olfaction_phenotype0.63428437
125MP0005499_abnormal_olfactory_system0.63428437
126MP0003938_abnormal_ear_development0.63241111
127MP0001188_hyperpigmentation0.63009372
128MP0003936_abnormal_reproductive_system0.58754574
129MP0000647_abnormal_sebaceous_gland0.58566559
130MP0005501_abnormal_skin_physiology0.57779079
131MP0003878_abnormal_ear_physiology0.57426094
132MP0005377_hearing/vestibular/ear_phenot0.57426094

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.52829238
2Abnormal number of erythroid precursors (HP:0012131)5.47660078
3Reticulocytopenia (HP:0001896)5.36237574
4Aplastic anemia (HP:0001915)4.28057533
5Birth length less than 3rd percentile (HP:0003561)4.03638613
6Acute necrotizing encephalopathy (HP:0006965)3.61229191
7Pallor (HP:0000980)3.60531799
8Macrocytic anemia (HP:0001972)3.53321042
9Chromsome breakage (HP:0040012)3.46513345
10Abnormality of the labia minora (HP:0012880)3.45637721
11Acute encephalopathy (HP:0006846)3.34373763
12Abnormal mitochondria in muscle tissue (HP:0008316)3.34112936
13Colon cancer (HP:0003003)3.22711118
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.20912292
15Breast hypoplasia (HP:0003187)3.19446610
16Patellar aplasia (HP:0006443)3.14709757
17Mitochondrial inheritance (HP:0001427)3.09829775
18Medulloblastoma (HP:0002885)3.02176182
19Oral leukoplakia (HP:0002745)3.01721193
20Increased CSF lactate (HP:0002490)3.00632111
21Aplasia/Hypoplasia of the patella (HP:0006498)2.99177739
22Abnormality of the preputium (HP:0100587)2.96115910
23Hepatocellular necrosis (HP:0001404)2.85269417
2411 pairs of ribs (HP:0000878)2.85126213
25Meckel diverticulum (HP:0002245)2.81811693
26Progressive macrocephaly (HP:0004481)2.80751570
27Abnormality of the ileum (HP:0001549)2.77171911
28Abnormality of chromosome stability (HP:0003220)2.77166950
29Acute lymphatic leukemia (HP:0006721)2.75750427
30Myelodysplasia (HP:0002863)2.75024515
31Thrombocytosis (HP:0001894)2.74897970
32Cleft eyelid (HP:0000625)2.61377049
33Hepatic necrosis (HP:0002605)2.60952147
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.60541828
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58086162
36Abnormal number of incisors (HP:0011064)2.55477917
37Cerebral edema (HP:0002181)2.54678041
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.52534561
39Asplenia (HP:0001746)2.44696479
40Type I transferrin isoform profile (HP:0003642)2.44492436
41Absent forearm bone (HP:0003953)2.43083944
42Aplasia involving forearm bones (HP:0009822)2.43083944
43Absent thumb (HP:0009777)2.41538798
44Selective tooth agenesis (HP:0001592)2.39593417
45Multiple enchondromatosis (HP:0005701)2.39252496
46Volvulus (HP:0002580)2.28078398
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.27913864
48Hyperglycinemia (HP:0002154)2.27278533
49Amaurosis fugax (HP:0100576)2.26877996
50Increased serum lactate (HP:0002151)2.26694666
51Triphalangeal thumb (HP:0001199)2.26272449
52Septo-optic dysplasia (HP:0100842)2.24543103
53Exertional dyspnea (HP:0002875)2.23148122
54Optic nerve coloboma (HP:0000588)2.22360635
55Neoplasm of the pancreas (HP:0002894)2.21632115
56Bone marrow hypocellularity (HP:0005528)2.21286176
57Duodenal stenosis (HP:0100867)2.20033619
58Small intestinal stenosis (HP:0012848)2.20033619
59Tracheoesophageal fistula (HP:0002575)2.16938718
60Abnormality of glycolysis (HP:0004366)2.16822578
61Abnormal lung lobation (HP:0002101)2.16127323
62Atresia of the external auditory canal (HP:0000413)2.15944077
63Increased serum pyruvate (HP:0003542)2.15749945
64Supernumerary spleens (HP:0009799)2.14217395
65Rough bone trabeculation (HP:0100670)2.12748990
66Pancytopenia (HP:0001876)2.10939925
67Lactic acidosis (HP:0003128)2.08850331
68Increased hepatocellular lipid droplets (HP:0006565)2.07792272
69Petechiae (HP:0000967)2.07227575
70Duplication of thumb phalanx (HP:0009942)2.06267192
71Agnosia (HP:0010524)2.05210808
72Microretrognathia (HP:0000308)2.04901743
73Renal Fanconi syndrome (HP:0001994)2.04830467
74Ectopic kidney (HP:0000086)2.02685521
75Carpal bone hypoplasia (HP:0001498)2.02602803
76Microvesicular hepatic steatosis (HP:0001414)2.02431161
77Megaloblastic anemia (HP:0001889)2.01973904
78Premature graying of hair (HP:0002216)2.01733056
79Abnormality of the anterior horn cell (HP:0006802)2.01512656
80Degeneration of anterior horn cells (HP:0002398)2.01512656
81Hypoplasia of the radius (HP:0002984)2.01479830
82Facial cleft (HP:0002006)2.01156258
83Absent septum pellucidum (HP:0001331)2.00706730
84Ependymoma (HP:0002888)1.99580604
85Abnormality of the carotid arteries (HP:0005344)1.99475364
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97649532
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97649532
88Nephroblastoma (Wilms tumor) (HP:0002667)1.97287311
89Sloping forehead (HP:0000340)1.96078193
90Horseshoe kidney (HP:0000085)1.95732486
91Leukodystrophy (HP:0002415)1.95560044
92Abnormality of the duodenum (HP:0002246)1.93768018
93Hypoplastic pelvis (HP:0008839)1.93494573
94Slender long bone (HP:0003100)1.93255231
95Abnormality of reticulocytes (HP:0004312)1.91863087
96IgM deficiency (HP:0002850)1.90765796
97Impulsivity (HP:0100710)1.90468843
98Abnormality of cochlea (HP:0000375)1.89103583
99Squamous cell carcinoma (HP:0002860)1.89090626
100Lymphoma (HP:0002665)1.87680879
101Trismus (HP:0000211)1.87588092
102Proximal placement of thumb (HP:0009623)1.86982392
103Exercise intolerance (HP:0003546)1.85676729
104Reduced antithrombin III activity (HP:0001976)1.85647768
105Abnormality of the septum pellucidum (HP:0007375)1.85404243
106Depressed nasal ridge (HP:0000457)1.83973301
107Short thumb (HP:0009778)1.83730000
108Overlapping toe (HP:0001845)1.83679529
109Increased nuchal translucency (HP:0010880)1.82902775
110Muscle fiber atrophy (HP:0100295)1.82789212
111Respiratory difficulties (HP:0002880)1.82767568
112Cellular immunodeficiency (HP:0005374)1.82302757
113Rhabdomyosarcoma (HP:0002859)1.82096690
114Hypoplasia of the pons (HP:0012110)1.81706988
115Short 4th metacarpal (HP:0010044)1.81135534
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.81135534
117Deviation of the thumb (HP:0009603)1.81068898
118Increased intramyocellular lipid droplets (HP:0012240)1.80424828
1193-Methylglutaconic aciduria (HP:0003535)1.80227247
120Clubbing of toes (HP:0100760)1.79969078
121Respiratory failure (HP:0002878)1.78755060
122Abnormality of DNA repair (HP:0003254)1.78144939
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78050056
124Embryonal renal neoplasm (HP:0011794)1.77951998
125Poikiloderma (HP:0001029)1.77403463
126Choanal atresia (HP:0000453)1.76692645
127Abnormality of serum amino acid levels (HP:0003112)1.75284138
128Thick lower lip vermilion (HP:0000179)1.73263843
129Short middle phalanx of the 5th finger (HP:0004220)1.72927130
130Missing ribs (HP:0000921)1.71882966
131Basal cell carcinoma (HP:0002671)1.71755421
132Glioma (HP:0009733)1.71281190
133Abnormality of the pons (HP:0007361)1.70722113
134Rib fusion (HP:0000902)1.70214617
135Abnormality of methionine metabolism (HP:0010901)1.68883921
136Testicular atrophy (HP:0000029)1.68329240
137Neoplasm of the colon (HP:0100273)1.68242059
138Broad face (HP:0000283)1.68026925
139Duplicated collecting system (HP:0000081)1.67290877
140Abnormality of the renal collecting system (HP:0004742)1.66421225
141Lipid accumulation in hepatocytes (HP:0006561)1.66000563
142Supernumerary bones of the axial skeleton (HP:0009144)1.65853734
143Aplasia/Hypoplasia of the sternum (HP:0006714)1.65218403
144Absent radius (HP:0003974)1.64840817
145Abnormal protein N-linked glycosylation (HP:0012347)1.62373673
146Abnormal glycosylation (HP:0012345)1.62373673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.47999349
2CDC74.29982799
3WEE13.89270140
4BUB13.35624002
5NME23.09752112
6SRPK12.76468567
7VRK12.48834009
8PASK2.42952443
9NEK22.42402160
10EIF2AK12.33329882
11STK162.31479613
12MKNK12.20935336
13TLK12.14743376
14CDK72.06409132
15PLK42.02386561
16TAF11.92894136
17BRSK21.92735349
18ACVR1B1.88274447
19MKNK21.84751580
20DYRK31.83177712
21NUAK11.75459611
22PIM21.70917224
23MST41.70240742
24RPS6KA41.67755732
25TTK1.64060072
26* ATR1.63211154
27AURKB1.62622222
28RPS6KB21.61924422
29PLK11.61333759
30CDK41.58293756
31TRIM281.55164065
32TGFBR11.53557616
33CHEK21.45865759
34EIF2AK31.45064791
35BLK1.41052605
36NEK11.34325425
37CDK81.29673101
38MAP3K101.29609839
39TESK21.24470012
40BRSK11.23280382
41STK41.19039843
42IRAK41.18228560
43BTK1.14480415
44CDK61.14100638
45TSSK61.13478754
46AURKA1.11162363
47PLK31.08689258
48WNK31.04200861
49MAP3K81.03651230
50BCKDK1.03470324
51EEF2K1.00741536
52CDK120.97250516
53BRD40.95301507
54CHEK10.92157567
55STK100.91022006
56PIM10.90844393
57TNIK0.90166030
58MAP3K60.88017043
59CCNB10.82747890
60YES10.82674646
61CLK10.82473852
62LRRK20.81619607
63ATM0.81361462
64ZAK0.78640747
65MAP4K10.78357175
66PNCK0.77453830
67PBK0.76610904
68CDK20.74103637
69EIF2AK20.72764402
70SMG10.72060309
71CSNK2A10.71376033
72TEC0.69858009
73RPS6KA50.69706237
74FLT30.69330312
75CSNK2A20.69191251
76PAK40.68835536
77PDK20.68701386
78CSNK1G10.68532995
79CSNK1G30.68272006
80CDK90.67120328
81DAPK10.66113004
82DYRK20.61921041
83KDR0.60481373
84MAP2K30.56549412
85KIT0.55957303
86BMPR1B0.55861034
87RPS6KA60.54264569
88MAP4K20.52920359
89BRAF0.52727074
90RPS6KL10.52454815
91RPS6KC10.52454815
92PAK10.52183208
93CDK10.52151109
94IRAK30.51104494
95MAP3K110.50584705
96JAK30.50582379
97CDK190.50193605
98PLK20.49256476
99TAOK20.49133055
100CSNK1A1L0.47948943
101TAOK30.47685191
102CSNK1G20.47083718
103CSNK1E0.46681123
104ILK0.46675109
105ZAP700.46337956
106PRKCI0.43787803
107EPHA20.43312055
108CDK30.42282138
109NEK90.41665354
110MAPKAPK20.41525933
111EPHA30.41435970
112NLK0.39986448
113STK30.39015563
114ALK0.38257321
115NME10.38199961
116LYN0.37436981
117PKN20.36681532
118MAPKAPK50.35430429
119MAP3K90.34879841
120MELK0.34687672
121SYK0.32280319
122MAPKAPK30.31819892
123SCYL20.30850973
124PRKDC0.29506164
125AKT20.29263163
126CDK180.28683823
127OXSR10.28515773
128ARAF0.28098164
129CDK11A0.28082138
130STK390.28007366
131CDK150.27620882
132MAP2K70.27078726
133CDK140.26753257
134ABL20.24751938
135FGFR10.23054376
136INSRR0.21442453
137GRK10.21346921

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.44486272
2Mismatch repair_Homo sapiens_hsa034304.53616427
3Ribosome_Homo sapiens_hsa030104.46350974
4Homologous recombination_Homo sapiens_hsa034403.32407060
5Spliceosome_Homo sapiens_hsa030403.23005824
6Base excision repair_Homo sapiens_hsa034103.04095277
7RNA polymerase_Homo sapiens_hsa030202.94537513
8Nucleotide excision repair_Homo sapiens_hsa034202.93937138
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80192315
10Cell cycle_Homo sapiens_hsa041102.63047782
11Proteasome_Homo sapiens_hsa030502.61950923
12RNA transport_Homo sapiens_hsa030132.49858623
13Pyrimidine metabolism_Homo sapiens_hsa002402.43108087
14Fanconi anemia pathway_Homo sapiens_hsa034602.32584333
15Non-homologous end-joining_Homo sapiens_hsa034502.21794891
16One carbon pool by folate_Homo sapiens_hsa006702.11590526
17Basal transcription factors_Homo sapiens_hsa030221.87650720
18RNA degradation_Homo sapiens_hsa030181.82627114
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74886391
20Protein export_Homo sapiens_hsa030601.67935477
21mRNA surveillance pathway_Homo sapiens_hsa030151.61872081
22p53 signaling pathway_Homo sapiens_hsa041151.52881030
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34777730
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33343269
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32527778
26Purine metabolism_Homo sapiens_hsa002301.26008593
27Pyruvate metabolism_Homo sapiens_hsa006201.21735737
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15097594
29Epstein-Barr virus infection_Homo sapiens_hsa051691.11022132
30Fatty acid elongation_Homo sapiens_hsa000621.08352666
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08000406
32Propanoate metabolism_Homo sapiens_hsa006401.07408479
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06984683
34Biosynthesis of amino acids_Homo sapiens_hsa012301.06437031
35Herpes simplex infection_Homo sapiens_hsa051681.05835562
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02299284
37Systemic lupus erythematosus_Homo sapiens_hsa053220.95459141
38Vitamin B6 metabolism_Homo sapiens_hsa007500.93855018
39Steroid biosynthesis_Homo sapiens_hsa001000.87517670
40Antigen processing and presentation_Homo sapiens_hsa046120.84387032
41Carbon metabolism_Homo sapiens_hsa012000.84284502
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81860037
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79475957
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79059755
45HTLV-I infection_Homo sapiens_hsa051660.78921727
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76631641
47Viral carcinogenesis_Homo sapiens_hsa052030.75534867
48N-Glycan biosynthesis_Homo sapiens_hsa005100.74362466
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72403055
50Cardiac muscle contraction_Homo sapiens_hsa042600.67172520
51Oocyte meiosis_Homo sapiens_hsa041140.66285074
52Primary immunodeficiency_Homo sapiens_hsa053400.65652299
53Huntingtons disease_Homo sapiens_hsa050160.65521172
54Thyroid cancer_Homo sapiens_hsa052160.64273336
55MicroRNAs in cancer_Homo sapiens_hsa052060.63097340
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62016858
57Metabolic pathways_Homo sapiens_hsa011000.61998681
58Basal cell carcinoma_Homo sapiens_hsa052170.61285571
59Parkinsons disease_Homo sapiens_hsa050120.59790723
60Sulfur relay system_Homo sapiens_hsa041220.59574892
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59189985
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59010796
63Folate biosynthesis_Homo sapiens_hsa007900.58357155
64Small cell lung cancer_Homo sapiens_hsa052220.54607203
65Notch signaling pathway_Homo sapiens_hsa043300.52753680
66Alcoholism_Homo sapiens_hsa050340.51027017
67Hepatitis B_Homo sapiens_hsa051610.50941040
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50637627
69Measles_Homo sapiens_hsa051620.48941262
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48528875
71Apoptosis_Homo sapiens_hsa042100.46553963
72Shigellosis_Homo sapiens_hsa051310.45534787
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.44676642
74Bladder cancer_Homo sapiens_hsa052190.43928236
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.43863270
76Chronic myeloid leukemia_Homo sapiens_hsa052200.43356549
77Asthma_Homo sapiens_hsa053100.42921794
78Hedgehog signaling pathway_Homo sapiens_hsa043400.42294829
79Legionellosis_Homo sapiens_hsa051340.42271335
80Pentose phosphate pathway_Homo sapiens_hsa000300.41150681
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40591437
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39419337
83Other glycan degradation_Homo sapiens_hsa005110.39349747
84Hematopoietic cell lineage_Homo sapiens_hsa046400.39202067
85Acute myeloid leukemia_Homo sapiens_hsa052210.38632560
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37726801
87Colorectal cancer_Homo sapiens_hsa052100.37364694
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37076865
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36657481
90Butanoate metabolism_Homo sapiens_hsa006500.36425653
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36026508
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35716803
93Oxidative phosphorylation_Homo sapiens_hsa001900.34243927
94Leishmaniasis_Homo sapiens_hsa051400.34125434
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34061143
96TGF-beta signaling pathway_Homo sapiens_hsa043500.33839387
97Arginine and proline metabolism_Homo sapiens_hsa003300.33130753
98Pathways in cancer_Homo sapiens_hsa052000.32056879
99Fatty acid metabolism_Homo sapiens_hsa012120.31570148
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31035896
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30495274
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.30164742
103Peroxisome_Homo sapiens_hsa041460.29675045
104Influenza A_Homo sapiens_hsa051640.28742604
105Lysine degradation_Homo sapiens_hsa003100.28172434
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27906239
107Arachidonic acid metabolism_Homo sapiens_hsa005900.27542045
108Hippo signaling pathway_Homo sapiens_hsa043900.27002987
109Vitamin digestion and absorption_Homo sapiens_hsa049770.26162259
110Wnt signaling pathway_Homo sapiens_hsa043100.26159346
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25863820
112Non-small cell lung cancer_Homo sapiens_hsa052230.24409416
113Glutathione metabolism_Homo sapiens_hsa004800.23515598
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.23118810
115Prostate cancer_Homo sapiens_hsa052150.22726848
116Selenocompound metabolism_Homo sapiens_hsa004500.22118773
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.21151913
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21103487
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20942584
120Melanoma_Homo sapiens_hsa052180.20835047
121Sulfur metabolism_Homo sapiens_hsa009200.20674701
122Phototransduction_Homo sapiens_hsa047440.20619819
123Caffeine metabolism_Homo sapiens_hsa002320.20571615
124beta-Alanine metabolism_Homo sapiens_hsa004100.18596913
125Alzheimers disease_Homo sapiens_hsa050100.18401357
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.18138725
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.17468948
128Pancreatic cancer_Homo sapiens_hsa052120.17203377
129Fatty acid degradation_Homo sapiens_hsa000710.16758465
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16609924
131B cell receptor signaling pathway_Homo sapiens_hsa046620.16411655
132Intestinal immune network for IgA production_Homo sapiens_hsa046720.16405540
133Tryptophan metabolism_Homo sapiens_hsa003800.14916463
134Tyrosine metabolism_Homo sapiens_hsa003500.14358629
135Galactose metabolism_Homo sapiens_hsa000520.14057275
136Fructose and mannose metabolism_Homo sapiens_hsa000510.13141689
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.06821596
138Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.06556721

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