GHSR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cysteine metabolic process (GO:0006534)8.55140114
2positive regulation of sodium ion transmembrane transporter activity (GO:2000651)7.18307588
3regulation of antigen processing and presentation of peptide antigen (GO:0002583)7.07860102
4dendritic spine morphogenesis (GO:0060997)6.41700683
5positive regulation of sodium ion transmembrane transport (GO:1902307)5.61970054
6regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)5.51327260
7dopamine biosynthetic process (GO:0042416)5.11395703
8vocalization behavior (GO:0071625)5.09378963
9neuron cell-cell adhesion (GO:0007158)5.08528549
10antigen processing and presentation via MHC class Ib (GO:0002475)4.95920925
11dopamine transport (GO:0015872)4.87055330
12positive regulation of synapse assembly (GO:0051965)4.70277923
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68481889
14behavioral response to nicotine (GO:0035095)4.56864864
15mating behavior (GO:0007617)4.48650357
16cerebellar Purkinje cell layer development (GO:0021680)4.45053944
17urinary tract smooth muscle contraction (GO:0014848)4.44362480
18sulfur amino acid catabolic process (GO:0000098)4.38033848
19catecholamine transport (GO:0051937)4.37970997
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.37969823
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.37969823
22axonal fasciculation (GO:0007413)4.36868736
23neuron recognition (GO:0008038)4.35201559
24negative regulation of peptidyl-serine phosphorylation (GO:0033137)4.21319534
25negative regulation of response to food (GO:0032096)4.20508977
26negative regulation of appetite (GO:0032099)4.20508977
27desmosome organization (GO:0002934)4.12167681
28negative regulation of Ras GTPase activity (GO:0034261)4.01389056
29regulation of synaptic vesicle exocytosis (GO:2000300)4.00937944
30negative regulation of keratinocyte proliferation (GO:0010839)4.00585217
31regulation of plasminogen activation (GO:0010755)3.98723489
32positive regulation of respiratory burst (GO:0060267)3.98067527
33peristalsis (GO:0030432)3.96988268
34homocysteine metabolic process (GO:0050667)3.94952125
35synaptic vesicle exocytosis (GO:0016079)3.94119803
36negative regulation of DNA biosynthetic process (GO:2000279)3.94014355
37adaptation of signaling pathway (GO:0023058)3.93511966
38organic cation transport (GO:0015695)3.93097860
39* regulation of synapse assembly (GO:0051963)3.92947084
40positive regulation of catecholamine secretion (GO:0033605)3.89909674
41postsynaptic membrane organization (GO:0001941)3.89184085
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.86597703
43inner ear receptor cell development (GO:0060119)3.84416876
44folic acid-containing compound biosynthetic process (GO:0009396)3.84274090
45negative regulation of organelle assembly (GO:1902116)3.79626183
46striatum development (GO:0021756)3.75980926
47eye photoreceptor cell differentiation (GO:0001754)3.74671040
48photoreceptor cell differentiation (GO:0046530)3.74671040
49regulation of synaptic vesicle transport (GO:1902803)3.68393249
50adenosine metabolic process (GO:0046085)3.65994920
51mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.65013909
52prepulse inhibition (GO:0060134)3.64885090
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.61886137
54endocrine pancreas development (GO:0031018)3.60480313
55primary amino compound metabolic process (GO:1901160)3.53907409
56mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.51534683
57neurotransmitter secretion (GO:0007269)3.50400875
58protein targeting to vacuole (GO:0006623)3.50066844
59protein targeting to lysosome (GO:0006622)3.50066844
60establishment of protein localization to vacuole (GO:0072666)3.50066844
61cellular response to pH (GO:0071467)3.45540527
62dendritic spine organization (GO:0097061)3.44555376
63pyrimidine nucleobase catabolic process (GO:0006208)3.44017010
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.43428309
65white fat cell differentiation (GO:0050872)3.40780350
66regulation of glutamate receptor signaling pathway (GO:1900449)3.39924281
67microtubule nucleation (GO:0007020)3.39573050
68opioid receptor signaling pathway (GO:0038003)3.39310808
69ATP synthesis coupled proton transport (GO:0015986)3.38673453
70energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38673453
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.38637944
72muscle atrophy (GO:0014889)3.38215034
73alkaloid metabolic process (GO:0009820)3.37375864
74pericardium development (GO:0060039)3.36133358
75xenobiotic catabolic process (GO:0042178)3.35307755
76negative regulation of microtubule polymerization (GO:0031115)3.34862168
77regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.34654702
78response to pheromone (GO:0019236)3.34581648
79nephron tubule morphogenesis (GO:0072078)3.34563043
80nephron epithelium morphogenesis (GO:0072088)3.34563043
81negative regulation of axon extension involved in axon guidance (GO:0048843)3.32813277
82synaptic vesicle maturation (GO:0016188)3.32596018
83pseudouridine synthesis (GO:0001522)3.30495558
84cell migration in hindbrain (GO:0021535)3.29551402
85regulation of microtubule-based movement (GO:0060632)3.29420757
86response to nitrosative stress (GO:0051409)3.26791860
87layer formation in cerebral cortex (GO:0021819)3.26540399
88regulation of catecholamine metabolic process (GO:0042069)3.26050977
89regulation of dopamine metabolic process (GO:0042053)3.26050977
90dosage compensation (GO:0007549)3.24310732
91G-protein coupled receptor internalization (GO:0002031)3.21997950
92neurotransmitter transport (GO:0006836)3.20789236
93positive regulation of endothelial cell differentiation (GO:0045603)3.19792895
94cochlea development (GO:0090102)3.16413706
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16148959
96phasic smooth muscle contraction (GO:0014821)3.16139990
97nonmotile primary cilium assembly (GO:0035058)3.15843038
98locomotory exploration behavior (GO:0035641)3.13116779
99catechol-containing compound biosynthetic process (GO:0009713)3.12513739
100catecholamine biosynthetic process (GO:0042423)3.12513739
101regulation of glutamate secretion (GO:0014048)3.11832273
102purine nucleotide salvage (GO:0032261)3.11431898
103cranial nerve morphogenesis (GO:0021602)3.10541533
104hindbrain development (GO:0030902)3.10451401
105* growth hormone secretion (GO:0030252)3.10117142
106protein localization to synapse (GO:0035418)3.09795493
107positive regulation of glycolytic process (GO:0045821)3.09567796
108regulation of long-term neuronal synaptic plasticity (GO:0048169)3.08627967
109regulation of endothelial cell differentiation (GO:0045601)3.08621336
110endosome to pigment granule transport (GO:0043485)3.08455698
111endosome to melanosome transport (GO:0035646)3.08455698
112central nervous system projection neuron axonogenesis (GO:0021952)3.08131000
113regulation of sequestering of triglyceride (GO:0010889)3.05992958
114positive regulation of antigen processing and presentation (GO:0002579)3.05849953
115regulation of neurotransmitter levels (GO:0001505)3.04129292
116kidney morphogenesis (GO:0060993)3.03742411
117proline transport (GO:0015824)3.03132857
118establishment of nucleus localization (GO:0040023)3.02942436
119innervation (GO:0060384)3.02120199
120regulation of sodium ion transmembrane transporter activity (GO:2000649)3.00890182
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.00443588
122auditory behavior (GO:0031223)3.00200720
123artery smooth muscle contraction (GO:0014824)2.99614444
124ionotropic glutamate receptor signaling pathway (GO:0035235)2.99589217
125cellular response to zinc ion (GO:0071294)2.98312860
126negative regulation of axon guidance (GO:1902668)2.97794767
127dendrite development (GO:0016358)2.97760562
128synapse assembly (GO:0007416)2.97197043
129regulation of axon extension involved in axon guidance (GO:0048841)2.97064791
130regulation of cilium movement (GO:0003352)2.96524705
131axon extension (GO:0048675)2.95412116
132regulation of neuronal synaptic plasticity (GO:0048168)2.95258380
133multicellular organism reproduction (GO:0032504)2.94616135
134* regulation of synapse organization (GO:0050807)2.94260164
135negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.93835713
136exploration behavior (GO:0035640)2.92446555
137one-carbon compound transport (GO:0019755)2.91960926
138* regulation of response to food (GO:0032095)2.91735984
139transmission of nerve impulse (GO:0019226)2.91482827
140regulation of transmission of nerve impulse (GO:0051969)2.90665278
141positive regulation of growth hormone secretion (GO:0060124)2.89828311
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88981145
143presynaptic membrane assembly (GO:0097105)2.88875644
144cellular response to leptin stimulus (GO:0044320)2.88453342
145forebrain neuron differentiation (GO:0021879)2.87427668
146positive regulation of potassium ion transmembrane transport (GO:1901381)2.86964472
147macroautophagy (GO:0016236)2.86475272
148pteridine-containing compound biosynthetic process (GO:0042559)2.85066685
149cell-cell junction maintenance (GO:0045217)2.84855434
150axonemal dynein complex assembly (GO:0070286)2.84828571
151phosphatidylglycerol biosynthetic process (GO:0006655)2.83981354
152regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83042323
153negative regulation of axon extension (GO:0030517)2.82739675
154gamma-aminobutyric acid signaling pathway (GO:0007214)2.82119632
155intraspecies interaction between organisms (GO:0051703)2.81677917
156social behavior (GO:0035176)2.81677917
157positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.80957591
158lateral sprouting from an epithelium (GO:0060601)2.80892074
159regulation of vesicle fusion (GO:0031338)2.80876559
160energy homeostasis (GO:0097009)2.79706427
161sulfur amino acid biosynthetic process (GO:0000097)2.79167210
162regulation of axon guidance (GO:1902667)2.78611460
163atrial cardiac muscle cell action potential (GO:0086014)2.78039692
164positive regulation of gastrulation (GO:2000543)2.77005677
165regulation of dopamine secretion (GO:0014059)2.76933871
166* regulation of appetite (GO:0032098)2.76178146
167response to histamine (GO:0034776)2.75863360
168regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75408384
169positive regulation of amine transport (GO:0051954)2.75401607
170ATP hydrolysis coupled proton transport (GO:0015991)2.74605113
171energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.74605113
172striated muscle atrophy (GO:0014891)2.72164644
173regulation of antigen processing and presentation (GO:0002577)2.69365875
174positive regulation of guanylate cyclase activity (GO:0031284)2.67916348
175protein K11-linked deubiquitination (GO:0035871)2.65671134
176epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.65296793
177activin receptor signaling pathway (GO:0032924)2.63717579
178protein localization to lysosome (GO:0061462)2.62784364
179protein localization to vacuole (GO:0072665)2.62784364
180regulation of mitochondrial membrane permeability (GO:0046902)2.61924735
181COPII vesicle coating (GO:0048208)2.61794378
182cytidine deamination (GO:0009972)2.60622441
183cytidine metabolic process (GO:0046087)2.60622441
184cytidine catabolic process (GO:0006216)2.60622441
185positive regulation of sodium ion transport (GO:0010765)2.60515760
186urate metabolic process (GO:0046415)2.60462188
187protein import into peroxisome matrix (GO:0016558)2.57737942
188positive regulation of oligodendrocyte differentiation (GO:0048714)2.57584780
189leukotriene biosynthetic process (GO:0019370)2.53465174
190positive regulation of gluconeogenesis (GO:0045722)2.53072418
191negative regulation of telomere maintenance (GO:0032205)2.51737589
192UDP-N-acetylglucosamine metabolic process (GO:0006047)2.51683695
193regulation of membrane permeability (GO:0090559)2.50270636
194cilium or flagellum-dependent cell motility (GO:0001539)2.48349675
195regulation of mesoderm development (GO:2000380)2.46904632
196antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.45560708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.78541125
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.42584612
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.08567693
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.85908346
5AR_21572438_ChIP-Seq_LNCaP_Human3.03457373
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98323597
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91926203
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86271981
9GBX2_23144817_ChIP-Seq_PC3_Human2.79617106
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.75400098
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.73065101
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69373571
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69373571
14* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.53504723
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.46866714
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46529939
17* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43720690
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.43447837
19* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35113279
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.34643797
21* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.30820229
22DROSHA_22980978_ChIP-Seq_HELA_Human2.30186657
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27966025
24* REST_21632747_ChIP-Seq_MESCs_Mouse2.26542206
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24584348
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.21055723
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.20077084
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17969192
29ZNF274_21170338_ChIP-Seq_K562_Hela2.07659386
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.93180421
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88689803
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83729575
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.81516639
34BCAT_22108803_ChIP-Seq_LS180_Human1.81211640
35STAT3_23295773_ChIP-Seq_U87_Human1.80545002
36RNF2_27304074_Chip-Seq_NSC_Mouse1.79708106
37* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75506941
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73581242
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68675860
40SMAD4_21799915_ChIP-Seq_A2780_Human1.67673169
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67010139
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66910076
43TP53_22573176_ChIP-Seq_HFKS_Human1.64175938
44TAF15_26573619_Chip-Seq_HEK293_Human1.63195527
45* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59607313
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.58812956
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55290963
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55263081
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.55096197
50ER_23166858_ChIP-Seq_MCF-7_Human1.54630127
51IGF1R_20145208_ChIP-Seq_DFB_Human1.52906373
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50847828
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.47384959
54TP53_16413492_ChIP-PET_HCT116_Human1.45195462
55* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45075842
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44345447
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.41219489
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.38556821
59OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.37723440
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.37357172
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35594368
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.35222975
63HOXB7_26014856_ChIP-Seq_BT474_Human1.34203920
64BP1_19119308_ChIP-ChIP_Hs578T_Human1.30270763
65P300_19829295_ChIP-Seq_ESCs_Human1.29758554
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.28719732
67MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27791156
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27672472
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27519681
70* OCT1_27270436_Chip-Seq_PROSTATE_Human1.27126275
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26104054
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25836812
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24603073
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.23084687
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22729704
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.22322911
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22258665
78ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21160423
79TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.20641760
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.20363326
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20140939
82* CDX2_22108803_ChIP-Seq_LS180_Human1.19159715
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18100374
84TCF4_22108803_ChIP-Seq_LS180_Human1.17739409
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17661345
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16802287
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.16360606
88MYC_19829295_ChIP-Seq_ESCs_Human1.16112682
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16041394
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15547585
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13990885
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13245872
93EZH2_27294783_Chip-Seq_NPCs_Mouse1.12980600
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12216460
95* TP53_20018659_ChIP-ChIP_R1E_Mouse1.09999495
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09966231
97TP53_18474530_ChIP-ChIP_U2OS_Human1.09800151
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09535398
99GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09380621
100* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09263947
101CJUN_26792858_Chip-Seq_BT549_Human1.08712639
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07613785
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.06800833
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.06257103
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06257103
106VDR_22108803_ChIP-Seq_LS180_Human1.06066241
107GATA2_21666600_ChIP-Seq_HMVEC_Human1.05812807
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05665206
109FOXH1_21741376_ChIP-Seq_ESCs_Human1.04866828
110FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04600024
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02672532
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02614005
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.02532353
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.02476495
115GATA3_26560356_Chip-Seq_TH2_Human1.02171887
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.01543629
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.00821582
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99575783
119SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99553123
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98712043
121CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97363503
122TBL1_22424771_ChIP-Seq_293T_Human0.97194747
123NANOG_19829295_ChIP-Seq_ESCs_Human0.97178812
124SOX2_19829295_ChIP-Seq_ESCs_Human0.97178812
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96659345
126CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96469716
127SOX2_20726797_ChIP-Seq_SW620_Human0.95904070
128AR_25329375_ChIP-Seq_VCAP_Human0.93345553
129AR_19668381_ChIP-Seq_PC3_Human0.91692034
130CTCF_27219007_Chip-Seq_Bcells_Human0.90980616
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90542725
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90264415
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89173593
134ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88788124
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87583276
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86808656
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86287758
138TCF4_23295773_ChIP-Seq_U87_Human0.86213580
139KDM2B_26808549_Chip-Seq_REH_Human0.85987302
140FUS_26573619_Chip-Seq_HEK293_Human0.85966972
141TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85612291
142POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85111553
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85111553
144* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84954931
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.83510173
146STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.82189608
147POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81588283
148EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81210499
149WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80985529
150ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80437272
151NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79605826
152RUNX2_22187159_ChIP-Seq_PCA_Human0.79117422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level5.82787076
2MP0003880_abnormal_central_pattern5.05217292
3MP0003122_maternal_imprinting4.66777533
4MP0006276_abnormal_autonomic_nervous3.64231518
5MP0002822_catalepsy3.58925720
6MP0003283_abnormal_digestive_organ3.31334636
7MP0002837_dystrophic_cardiac_calcinosis3.26219059
8MP0004859_abnormal_synaptic_plasticity3.23789145
9MP0005645_abnormal_hypothalamus_physiol3.22367190
10MP0005220_abnormal_exocrine_pancreas2.78751333
11MP0003635_abnormal_synaptic_transmissio2.77236935
12MP0001984_abnormal_olfaction2.76906717
13MP0001529_abnormal_vocalization2.68820086
14MP0005360_urolithiasis2.64344209
15MP0005167_abnormal_blood-brain_barrier2.53168504
16MP0003183_abnormal_peptide_metabolism2.50459925
17MP0005670_abnormal_white_adipose2.44619650
18MP0004130_abnormal_muscle_cell2.42729470
19MP0003868_abnormal_feces_composition2.41379083
20* MP0002063_abnormal_learning/memory/cond2.32865404
21MP0008995_early_reproductive_senescence2.26570126
22MP0002909_abnormal_adrenal_gland2.26304949
23MP0005084_abnormal_gallbladder_morpholo2.24006200
24MP0000013_abnormal_adipose_tissue2.18205610
25MP0002572_abnormal_emotion/affect_behav2.15045664
26MP0001440_abnormal_grooming_behavior2.14078843
27MP0002064_seizures2.14073596
28MP0002938_white_spotting2.12563938
29MP0003121_genomic_imprinting2.11396353
30MP0002734_abnormal_mechanical_nocicepti2.09645405
31MP0009745_abnormal_behavioral_response2.08418694
32MP0000778_abnormal_nervous_system2.07986031
33MP0004043_abnormal_pH_regulation2.03893325
34MP0004270_analgesia2.03480527
35MP0001968_abnormal_touch/_nociception1.98951748
36MP0001905_abnormal_dopamine_level1.97999260
37MP0001486_abnormal_startle_reflex1.97089992
38MP0003646_muscle_fatigue1.97060143
39MP0001502_abnormal_circadian_rhythm1.94318764
40MP0005646_abnormal_pituitary_gland1.89429713
41MP0009046_muscle_twitch1.87433005
42MP0005423_abnormal_somatic_nervous1.80563523
43MP0001970_abnormal_pain_threshold1.76441716
44MP0002102_abnormal_ear_morphology1.73423064
45MP0002132_abnormal_respiratory_system1.71446668
46MP0002184_abnormal_innervation1.70525705
47MP0001501_abnormal_sleep_pattern1.69015799
48MP0002272_abnormal_nervous_system1.65880006
49MP0002733_abnormal_thermal_nociception1.65433900
50MP0005076_abnormal_cell_differentiation1.65340882
51MP0004142_abnormal_muscle_tone1.64409248
52MP0005386_behavior/neurological_phenoty1.62919812
53MP0004924_abnormal_behavior1.62919812
54MP0002067_abnormal_sensory_capabilities1.61491344
55MP0004145_abnormal_muscle_electrophysio1.60839990
56MP0000631_abnormal_neuroendocrine_gland1.60676272
57MP0002557_abnormal_social/conspecific_i1.58923748
58MP0005551_abnormal_eye_electrophysiolog1.57207199
59MP0001756_abnormal_urination1.56661178
60MP0003195_calcinosis1.56486096
61MP0008961_abnormal_basal_metabolism1.51470397
62MP0001986_abnormal_taste_sensitivity1.49628596
63MP0000537_abnormal_urethra_morphology1.47160559
64MP0005332_abnormal_amino_acid1.46910593
65MP0000383_abnormal_hair_follicle1.46599954
66MP0004742_abnormal_vestibular_system1.45311078
67MP0001348_abnormal_lacrimal_gland1.44584106
68MP0004885_abnormal_endolymph1.43780544
69MP0002876_abnormal_thyroid_physiology1.42283571
70MP0000569_abnormal_digit_pigmentation1.39477800
71MP0002928_abnormal_bile_duct1.38828949
72MP0001299_abnormal_eye_distance/1.35329912
73MP0004811_abnormal_neuron_physiology1.34506379
74MP0000538_abnormal_urinary_bladder1.33580803
75MP0002095_abnormal_skin_pigmentation1.32909362
76MP0003172_abnormal_lysosome_physiology1.32868029
77MP0002735_abnormal_chemical_nociception1.32772540
78MP0008438_abnormal_cutaneous_collagen1.32712674
79MP0010329_abnormal_lipoprotein_level1.31116404
80MP0002693_abnormal_pancreas_physiology1.30324813
81MP0006072_abnormal_retinal_apoptosis1.29776476
82MP0004134_abnormal_chest_morphology1.28641132
83MP0010678_abnormal_skin_adnexa1.26953388
84* MP0008872_abnormal_physiological_respon1.25355489
85MP0010386_abnormal_urinary_bladder1.25043793
86MP0000427_abnormal_hair_cycle1.24580974
87MP0000015_abnormal_ear_pigmentation1.22769242
88MP0000470_abnormal_stomach_morphology1.21644369
89MP0009643_abnormal_urine_homeostasis1.18670625
90MP0005503_abnormal_tendon_morphology1.18472835
91* MP0002066_abnormal_motor_capabilities/c1.18101422
92MP0005083_abnormal_biliary_tract1.17690565
93MP0002882_abnormal_neuron_morphology1.16483551
94MP0000003_abnormal_adipose_tissue1.15129127
95MP0009379_abnormal_foot_pigmentation1.14913476
96MP0000955_abnormal_spinal_cord1.13338188
97MP0003045_fibrosis1.13298430
98MP0003315_abnormal_perineum_morphology1.11533202
99MP0005275_abnormal_skin_tensile1.11464922
100MP0004133_heterotaxia1.10691215
101MP0002736_abnormal_nociception_after1.10481605
102MP0000371_diluted_coat_color1.09223280
103MP0002160_abnormal_reproductive_system1.08638424
104MP0009697_abnormal_copulation1.07988050
105MP0001661_extended_life_span1.07758941
106MP0003329_amyloid_beta_deposits1.06919426
107MP0000230_abnormal_systemic_arterial1.05102905
108MP0008877_abnormal_DNA_methylation1.04638941
109MP0002638_abnormal_pupillary_reflex1.01065993
110MP0003959_abnormal_lean_body1.00244490
111MP0009840_abnormal_foam_cell0.99764703
112* MP0002069_abnormal_eating/drinking_beha0.98339198
113MP0008875_abnormal_xenobiotic_pharmacok0.98325110
114MP0005253_abnormal_eye_physiology0.96722127
115MP0002152_abnormal_brain_morphology0.96531260
116MP0001849_ear_inflammation0.96107187
117MP0005394_taste/olfaction_phenotype0.95125157
118MP0005499_abnormal_olfactory_system0.95125157
119* MP0002078_abnormal_glucose_homeostasis0.91717764
120MP0005409_darkened_coat_color0.88640949
121MP0003705_abnormal_hypodermis_morpholog0.88542816
122MP0003123_paternal_imprinting0.86416887
123MP0000462_abnormal_digestive_system0.84596822
124MP0003890_abnormal_embryonic-extraembry0.84247391
125MP0005379_endocrine/exocrine_gland_phen0.83890648
126MP0003119_abnormal_digestive_system0.83585031
127MP0000751_myopathy0.82619581
128MP0003633_abnormal_nervous_system0.81627702
129MP0001664_abnormal_digestion0.81419698
130MP0003303_peritoneal_inflammation0.80603479
131MP0002295_abnormal_pulmonary_circulatio0.79509252
132MP0005535_abnormal_body_temperature0.78884165
133* MP0003953_abnormal_hormone_level0.78236506
134MP0002933_joint_inflammation0.78131725
135MP0001666_abnormal_nutrient_absorption0.78071267
136MP0002282_abnormal_trachea_morphology0.77542149
137MP0003942_abnormal_urinary_system0.77084851
138MP0005174_abnormal_tail_pigmentation0.76479842
139MP0003186_abnormal_redox_activity0.75611832
140MP0004858_abnormal_nervous_system0.75112636
141MP0001851_eye_inflammation0.74310213
142MP0005647_abnormal_sex_gland0.73763684
143MP0009780_abnormal_chondrocyte_physiolo0.72623959
144MP0003724_increased_susceptibility_to0.72522958
145MP0008775_abnormal_heart_ventricle0.71680791
146MP0002751_abnormal_autonomic_nervous0.71317827
147MP0002752_abnormal_somatic_nervous0.70487035
148MP0003787_abnormal_imprinting0.69998390
149MP0001919_abnormal_reproductive_system0.69540122
150MP0002163_abnormal_gland_morphology0.68745699
151MP0003137_abnormal_impulse_conducting0.68065567
152MP0002234_abnormal_pharynx_morphology0.67470582
153MP0004085_abnormal_heartbeat0.67181460
154MP0008789_abnormal_olfactory_epithelium0.67122665
155MP0001943_abnormal_respiration0.66528866
156MP0001727_abnormal_embryo_implantation0.64417723
157MP0005389_reproductive_system_phenotype0.62802584
158MP0001188_hyperpigmentation0.58480076
159MP0001944_abnormal_pancreas_morphology0.58117805
160MP0003861_abnormal_nervous_system0.57939835
161MP0000534_abnormal_ureter_morphology0.57007837
162MP0002082_postnatal_lethality0.56791731
163MP0010770_preweaning_lethality0.56791731

Predicted human phenotypes

RankGene SetZ-score
1Limb dystonia (HP:0002451)7.58654878
2Failure to thrive in infancy (HP:0001531)6.65364150
3Breast hypoplasia (HP:0003187)6.06314330
4Polyphagia (HP:0002591)5.76228107
5Focal seizures (HP:0007359)5.22839380
6Nuclear cataract (HP:0100018)4.73980229
7Congenital sensorineural hearing impairment (HP:0008527)4.68548985
8Type II lissencephaly (HP:0007260)4.48244329
9Microretrognathia (HP:0000308)4.31469523
10Chorioretinal atrophy (HP:0000533)4.28665551
11Myokymia (HP:0002411)4.18649255
12Abnormal eating behavior (HP:0100738)4.00895208
13Focal motor seizures (HP:0011153)3.98938429
14Hypoventilation (HP:0002791)3.86373551
15Global brain atrophy (HP:0002283)3.83788791
16Pheochromocytoma (HP:0002666)3.83097743
17Esotropia (HP:0000565)3.81295784
18Visual hallucinations (HP:0002367)3.71653788
19Gait imbalance (HP:0002141)3.63192214
20Attenuation of retinal blood vessels (HP:0007843)3.59799144
21Abnormal hair whorl (HP:0010721)3.55728616
22Abnormality of the fingertips (HP:0001211)3.47476035
23Spontaneous hematomas (HP:0007420)3.45276403
24Chronic hepatic failure (HP:0100626)3.35306375
25Supranuclear gaze palsy (HP:0000605)3.33489792
26Sleep apnea (HP:0010535)3.32172064
27Neuroendocrine neoplasm (HP:0100634)3.24906244
28Hypoplastic labia majora (HP:0000059)3.22033493
29Slender long bone (HP:0003100)3.19927552
30Abnormal sex determination (HP:0012244)3.16844648
31Sex reversal (HP:0012245)3.16844648
32Decreased electroretinogram (ERG) amplitude (HP:0000654)3.15725634
33Generalized hypotonia (HP:0001290)3.03722780
34Cerebral inclusion bodies (HP:0100314)3.03402498
35Aplasia/Hypoplasia of the sternum (HP:0006714)2.95061799
36Abnormality of the labia minora (HP:0012880)2.90798143
37Abnormality of the labia majora (HP:0012881)2.90265617
38Narrow nasal bridge (HP:0000446)2.85591579
39Pancreatic fibrosis (HP:0100732)2.85135014
40Cerebellar dysplasia (HP:0007033)2.83780983
41Constricted visual fields (HP:0001133)2.80356128
42Pendular nystagmus (HP:0012043)2.79413163
43Broad-based gait (HP:0002136)2.78397888
44Neurofibrillary tangles (HP:0002185)2.76715968
45Specific learning disability (HP:0001328)2.76675379
46Toxemia of pregnancy (HP:0100603)2.74436063
47Congenital primary aphakia (HP:0007707)2.71273059
48Ventricular fibrillation (HP:0001663)2.70391889
49Decreased circulating renin level (HP:0003351)2.69583061
50Febrile seizures (HP:0002373)2.67858604
51Open mouth (HP:0000194)2.67646067
52Hyperkalemia (HP:0002153)2.66393401
53Increased circulating renin level (HP:0000848)2.62033823
54Fetal akinesia sequence (HP:0001989)2.59827456
55Patellar aplasia (HP:0006443)2.59765569
56Mutism (HP:0002300)2.59018241
57Metaphyseal dysplasia (HP:0100255)2.58119624
58Microtia (HP:0008551)2.56851275
59Testicular neoplasm (HP:0010788)2.54545027
60Gastrointestinal infarctions (HP:0005244)2.53542430
61Congenital stationary night blindness (HP:0007642)2.46211191
62Inability to walk (HP:0002540)2.45360814
63Nephrogenic diabetes insipidus (HP:0009806)2.44180872
64Insomnia (HP:0100785)2.43920323
65Agitation (HP:0000713)2.43615799
66Aplasia/Hypoplasia of the patella (HP:0006498)2.43451241
67Rectal prolapse (HP:0002035)2.43257323
68Pancreatic cysts (HP:0001737)2.42179235
69Atonic seizures (HP:0010819)2.41766634
70Oligomenorrhea (HP:0000876)2.41521290
71Cone-rod dystrophy (HP:0000548)2.39902751
72Keratoconus (HP:0000563)2.37238885
73Increased corneal curvature (HP:0100692)2.37238885
74Medial flaring of the eyebrow (HP:0010747)2.36299901
75Large eyes (HP:0001090)2.34104369
76Esophageal varix (HP:0002040)2.33867292
77Vaginal atresia (HP:0000148)2.33761227
78Abolished electroretinogram (ERG) (HP:0000550)2.31569181
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30809400
80Retinal dysplasia (HP:0007973)2.29473806
81Renal duplication (HP:0000075)2.27714734
82Disproportionate short-trunk short stature (HP:0003521)2.26518426
83Hypoplastic female external genitalia (HP:0012815)2.26232993
84Psychosis (HP:0000709)2.25945874
85Morphological abnormality of the pyramidal tract (HP:0002062)2.22331471
86Zonular cataract (HP:0010920)2.21281424
87Pigmentary retinal degeneration (HP:0001146)2.20531564
88Hip dysplasia (HP:0001385)2.19867762
89Abnormal pupillary function (HP:0007686)2.19428399
90Generalized tonic-clonic seizures (HP:0002069)2.18764581
91Papilledema (HP:0001085)2.17094182
92Genital tract atresia (HP:0001827)2.16984794
93Lissencephaly (HP:0001339)2.16445686
94Widely spaced teeth (HP:0000687)2.16134906
95Dynein arm defect of respiratory motile cilia (HP:0012255)2.15780468
96Absent/shortened dynein arms (HP:0200106)2.15780468
97Hyperacusis (HP:0010780)2.15620574
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15445645
99Abnormality of alanine metabolism (HP:0010916)2.15445645
100Hyperalaninemia (HP:0003348)2.15445645
101Poor speech (HP:0002465)2.13512916
102Progressive cerebellar ataxia (HP:0002073)2.12454974
103Amblyopia (HP:0000646)2.12146541
104Hypothermia (HP:0002045)2.12063185
105Anxiety (HP:0000739)2.11668476
106Torticollis (HP:0000473)2.09845121
107Delayed gross motor development (HP:0002194)2.09600350
108Abnormality of the renal cortex (HP:0011035)2.09276620
109True hermaphroditism (HP:0010459)2.08789104
110Cerebral hemorrhage (HP:0001342)2.08183491
111Hypomagnesemia (HP:0002917)2.07403050
112Abnormal ciliary motility (HP:0012262)2.06666759
113Aplasia/Hypoplasia of the lens (HP:0008063)2.05960842
114Abnormal respiratory epithelium morphology (HP:0012253)2.05489003
115Abnormal respiratory motile cilium morphology (HP:0005938)2.05489003
116Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04951731
117Abnormality of calcium-phosphate metabolism (HP:0100530)2.04622924
118Absence seizures (HP:0002121)2.04252064
119Nasal speech (HP:0001611)2.03887705
120Abnormality of pain sensation (HP:0010832)2.02728702
121Impaired pain sensation (HP:0007328)2.02728702
122Acute necrotizing encephalopathy (HP:0006965)2.01956475
123Fair hair (HP:0002286)2.01078994
124Prolonged QT interval (HP:0001657)2.00542120
125Birth length less than 3rd percentile (HP:0003561)10.4449649
126Sporadic (HP:0003745)1.99628551
127Abnormality of serum amino acid levels (HP:0003112)1.99567409
128Small hand (HP:0200055)1.99318480
129Abnormality of midbrain morphology (HP:0002418)1.98037315
130Molar tooth sign on MRI (HP:0002419)1.98037315
131Breast aplasia (HP:0100783)1.97649565
132Dialeptic seizures (HP:0011146)1.97593635
133Genu varum (HP:0002970)1.96739272
134Drooling (HP:0002307)1.94976429
135Excessive salivation (HP:0003781)1.94976429
136Hyperventilation (HP:0002883)1.94164576
137Poor coordination (HP:0002370)1.93973207
138Growth hormone deficiency (HP:0000824)1.93596611
139Protruding tongue (HP:0010808)1.93548293
140Hematochezia (HP:0002573)1.93320005
141Increased hepatocellular lipid droplets (HP:0006565)1.93143086
142Clumsiness (HP:0002312)1.92853482
143Absent speech (HP:0001344)1.92432219
144Generalized aminoaciduria (HP:0002909)1.91842536
145Labial hypoplasia (HP:0000066)1.91143264
146Morphological abnormality of the middle ear (HP:0008609)1.91053168
147Long foot (HP:0001833)1.90850491
148Mitochondrial inheritance (HP:0001427)1.90642031
149Bowel diverticulosis (HP:0005222)1.89820715
150Progressive inability to walk (HP:0002505)1.89431426
151Hypoplasia of the odontoid process (HP:0003311)1.86712462
152White forelock (HP:0002211)1.86644820
153Progressive macrocephaly (HP:0004481)1.86511041
154Chronic otitis media (HP:0000389)1.86433651
155Abnormal respiratory motile cilium physiology (HP:0012261)1.85841844
156Abnormal EKG (HP:0003115)1.85203262
157Tinnitus (HP:0000360)1.85143565
158Scrotal hypoplasia (HP:0000046)1.83025674
159Sacral dimple (HP:0000960)1.82818416
160Spastic tetraparesis (HP:0001285)1.82162854
161Diastasis recti (HP:0001540)1.82162529
162Coxa vara (HP:0002812)1.81835360
163Abnormality of the wing of the ilium (HP:0011867)1.81826754
164Exotropia (HP:0000577)1.81744200
165Hypoplasia of the maxilla (HP:0000327)1.80834092
166Abnormal mitochondria in muscle tissue (HP:0008316)1.80394035
167Postural tremor (HP:0002174)1.79404980
168Hydroureter (HP:0000072)1.79257047
169Craniofacial dystonia (HP:0012179)1.79018084
170Hepatocellular necrosis (HP:0001404)1.78745570
171Abnormality of the vitreous humor (HP:0004327)1.78562494
172Patchy hypopigmentation of hair (HP:0011365)1.77919332
173Increased density of long bones (HP:0006392)1.76828587
174Diplopia (HP:0000651)1.75895513
175Abnormality of binocular vision (HP:0011514)1.75895513
176Tubular atrophy (HP:0000092)1.75763970
177Nephronophthisis (HP:0000090)1.73372561
178Hyperglycemia (HP:0003074)1.73331479
179Conjunctival telangiectasia (HP:0000524)1.72945925
180Biliary tract neoplasm (HP:0100574)1.71931910
181Aplasia/Hypoplasia of the tibia (HP:0005772)1.71685263
182Type II diabetes mellitus (HP:0005978)1.70423644
183Abnormality of the clitoris (HP:0000056)1.67885303
184High pitched voice (HP:0001620)1.65574111
185Ketoacidosis (HP:0001993)1.64297296
186Nasal polyposis (HP:0100582)1.63430740
187Prominent supraorbital ridges (HP:0000336)1.62466993

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.64549660
2MARK14.85152679
3INSRR4.79977886
4UHMK13.75547055
5NTRK33.64857077
6PNCK3.37602521
7EPHB23.28375814
8PAK33.06202525
9PAK62.78377102
10CDK122.74702412
11KSR12.73131244
12MAP3K32.40495499
13BRD42.17861638
14IRAK22.17809285
15WNK32.12225026
16PHKG12.07122728
17PHKG22.07122728
18MAP2K62.00858844
19MAP3K121.85509984
20CAMKK11.84460957
21JAK31.77068399
22DYRK21.72669913
23MAP3K41.69469654
24MAP3K101.68327836
25CASK1.66098657
26CAMK1G1.65637592
27NTRK21.64477121
28CDK91.62995121
29MINK11.58085969
30MAPK131.54273264
31SCYL21.50633317
32DYRK1A1.46932918
33BMPR1B1.39220270
34CDK51.33803137
35PLK21.29893826
36CDK181.29121932
37CDK151.27763696
38CSNK1G21.25128104
39CSNK1G31.24494761
40CDK141.23951964
41MAP2K71.22097405
42GRK51.19498627
43NME11.19019788
44MAP2K31.17606937
45MAP2K41.14150030
46CDK11A1.13371226
47FGFR21.12364559
48SIK21.10160464
49ERBB21.09495049
50ADRBK21.09385931
51EPHA41.07557493
52LATS21.06144782
53CAMK2A1.05847180
54IRAK40.99557930
55TNIK0.96938152
56RPS6KA60.93165986
57CAMK10.92721751
58NEK90.92171424
59MAP3K70.92051670
60CDK190.90962763
61MELK0.87466193
62FES0.87068761
63NTRK10.86860147
64MAP2K20.86794725
65CSNK1G10.86770942
66ADRBK10.85134098
67GRK70.81972675
68MAPKAPK50.81493816
69GRK10.80803679
70PAK20.80473197
71SGK20.79216723
72STK30.77405117
73ZAK0.77235148
74MAP3K90.76664633
75FRK0.76288437
76STK38L0.73284365
77IKBKB0.72762789
78CAMK1D0.70785602
79MUSK0.70095543
80MAP3K110.69881054
81MAP4K20.68402287
82ERBB30.67346004
83LATS10.66799732
84TLK10.66349385
85PRKAA20.65437115
86PRKCG0.65190750
87FGR0.62011544
88FER0.61367514
89EPHB10.61050886
90STK380.60656813
91MKNK20.59005230
92RPS6KA20.58686473
93MAPK40.57746478
94PRKCZ0.57464790
95CSNK1A10.56328924
96RPS6KC10.56286052
97RPS6KL10.56286052
98CAMK2B0.56134246
99RET0.56132278
100TRPM70.55797585
101EIF2AK20.54721279
102WNK40.53387060
103PRKCH0.52262332
104CAMK2G0.51611794
105FYN0.51013435
106TNK20.50590892
107BCR0.49392059
108RPS6KB10.48662083
109MAP4K10.48658630
110PRKG20.48516406
111CSF1R0.47784166
112ABL20.47415110
113RPS6KA50.47010695
114PRKACA0.46467082
115CAMK2D0.45922770
116PRKCE0.45492206
117PKN10.44096489
118PIK3CG0.43761860
119PRKACG0.43274000
120PRKG10.40399246
121HIPK20.39957183
122SRPK10.39376196
123GSK3A0.38076832
124PTK2B0.38048395
125SGK10.37731601
126STK110.37489546
127OXSR10.36824779
128CSNK1E0.36657197
129MAP3K20.36585452
130SGK2230.36025664
131SGK4940.36025664
132NUAK10.35720727
133PIK3CA0.35120810
134TYRO30.34915834
135DAPK20.33423122
136PRKAA10.32250686
137MAP2K10.32134041
138CAMKK20.32061575
139MAPK90.31950836
140TGFBR10.31941029
141TAOK30.31591413
142BMX0.28571610
143RPS6KB20.27962190
144PRKCA0.27186826
145CAMK40.25937259
146NEK20.24718552
147BCKDK0.22858368
148NEK60.22667968
149SGK30.22648270
150RPS6KA30.21058470
151SYK0.20310230
152PDK10.19751002
153LYN0.19430868
154PRKACB0.18428644

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73586798
2Nitrogen metabolism_Homo sapiens_hsa009103.27969970
3Parkinsons disease_Homo sapiens_hsa050123.12922618
4Oxidative phosphorylation_Homo sapiens_hsa001903.10238310
5Cocaine addiction_Homo sapiens_hsa050302.84849650
6Synaptic vesicle cycle_Homo sapiens_hsa047212.80829470
7GABAergic synapse_Homo sapiens_hsa047272.66921470
8Amphetamine addiction_Homo sapiens_hsa050312.61269685
9Arginine biosynthesis_Homo sapiens_hsa002202.53808248
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.47873556
11Alzheimers disease_Homo sapiens_hsa050102.33365187
12Circadian entrainment_Homo sapiens_hsa047132.22345787
13ABC transporters_Homo sapiens_hsa020102.21775548
14Morphine addiction_Homo sapiens_hsa050322.19314115
15Dopaminergic synapse_Homo sapiens_hsa047282.11870613
16Huntingtons disease_Homo sapiens_hsa050162.07313719
17Glutamatergic synapse_Homo sapiens_hsa047241.96940125
18Insulin secretion_Homo sapiens_hsa049111.95472506
19SNARE interactions in vesicular transport_Homo sapiens_hsa041301.94875313
20Cardiac muscle contraction_Homo sapiens_hsa042601.91392841
21One carbon pool by folate_Homo sapiens_hsa006701.85610784
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.80076124
23Serotonergic synapse_Homo sapiens_hsa047261.75184988
24Selenocompound metabolism_Homo sapiens_hsa004501.73481862
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73146344
26Long-term potentiation_Homo sapiens_hsa047201.71001585
27Vibrio cholerae infection_Homo sapiens_hsa051101.67737183
28Taste transduction_Homo sapiens_hsa047421.65011061
29Cholinergic synapse_Homo sapiens_hsa047251.60641858
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60509889
31Collecting duct acid secretion_Homo sapiens_hsa049661.57922058
32Linoleic acid metabolism_Homo sapiens_hsa005911.56839407
33* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51956960
34Axon guidance_Homo sapiens_hsa043601.50185184
35Gastric acid secretion_Homo sapiens_hsa049711.43933998
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40642010
37Ether lipid metabolism_Homo sapiens_hsa005651.40001486
38Olfactory transduction_Homo sapiens_hsa047401.38667703
39Mineral absorption_Homo sapiens_hsa049781.36173375
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34527263
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33482690
42Regulation of autophagy_Homo sapiens_hsa041401.32596216
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.32324091
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25750849
45Gap junction_Homo sapiens_hsa045401.24796993
46Hedgehog signaling pathway_Homo sapiens_hsa043401.22560749
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20520314
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.17305542
49Melanogenesis_Homo sapiens_hsa049161.15246439
50Renin secretion_Homo sapiens_hsa049241.13652945
51Tryptophan metabolism_Homo sapiens_hsa003801.12161123
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08923067
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08275123
54Calcium signaling pathway_Homo sapiens_hsa040201.07707087
55Salivary secretion_Homo sapiens_hsa049701.06690742
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02598255
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01955424
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.00541765
59Alcoholism_Homo sapiens_hsa050341.00142137
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99466191
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96347240
62Chemical carcinogenesis_Homo sapiens_hsa052040.93650394
63Long-term depression_Homo sapiens_hsa047300.93566274
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93499531
65Ribosome_Homo sapiens_hsa030100.92162308
66GnRH signaling pathway_Homo sapiens_hsa049120.90789122
67Retinol metabolism_Homo sapiens_hsa008300.90589320
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90499927
69Fatty acid biosynthesis_Homo sapiens_hsa000610.88972911
70Sulfur relay system_Homo sapiens_hsa041220.88520782
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.83507131
72Butanoate metabolism_Homo sapiens_hsa006500.82645681
73Type I diabetes mellitus_Homo sapiens_hsa049400.80686774
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78624499
75Type II diabetes mellitus_Homo sapiens_hsa049300.78526017
76Galactose metabolism_Homo sapiens_hsa000520.77539692
77Peroxisome_Homo sapiens_hsa041460.77175086
78Protein export_Homo sapiens_hsa030600.76643720
79Arachidonic acid metabolism_Homo sapiens_hsa005900.75945310
80Basal cell carcinoma_Homo sapiens_hsa052170.74886725
81Oxytocin signaling pathway_Homo sapiens_hsa049210.74192004
82Dilated cardiomyopathy_Homo sapiens_hsa054140.71979225
83Estrogen signaling pathway_Homo sapiens_hsa049150.71176822
84Renal cell carcinoma_Homo sapiens_hsa052110.71061063
85Thyroid hormone synthesis_Homo sapiens_hsa049180.71040872
86Wnt signaling pathway_Homo sapiens_hsa043100.70755531
87Prion diseases_Homo sapiens_hsa050200.65718270
88Vitamin digestion and absorption_Homo sapiens_hsa049770.65618871
89ErbB signaling pathway_Homo sapiens_hsa040120.62515008
90Lysosome_Homo sapiens_hsa041420.62391879
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.61681779
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60973451
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60085052
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59419287
95Ovarian steroidogenesis_Homo sapiens_hsa049130.58887579
96Sulfur metabolism_Homo sapiens_hsa009200.56621464
97Glucagon signaling pathway_Homo sapiens_hsa049220.56609874
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55984197
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54589486
100* cAMP signaling pathway_Homo sapiens_hsa040240.54224848
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53321819
102Ras signaling pathway_Homo sapiens_hsa040140.52459683
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52386901
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51043163
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50566970
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50109148
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49106707
108Glutathione metabolism_Homo sapiens_hsa004800.48329535
109Circadian rhythm_Homo sapiens_hsa047100.47878028
110Phototransduction_Homo sapiens_hsa047440.47815053
111Caffeine metabolism_Homo sapiens_hsa002320.47792890
112Phenylalanine metabolism_Homo sapiens_hsa003600.47102852
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46751308
114Phagosome_Homo sapiens_hsa041450.46043561
115Sphingolipid metabolism_Homo sapiens_hsa006000.45678917
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45198858
117Arginine and proline metabolism_Homo sapiens_hsa003300.44497384
118Starch and sucrose metabolism_Homo sapiens_hsa005000.43701644
119Tyrosine metabolism_Homo sapiens_hsa003500.42600607
120Hippo signaling pathway_Homo sapiens_hsa043900.41894298
121Basal transcription factors_Homo sapiens_hsa030220.41783724
122Pancreatic secretion_Homo sapiens_hsa049720.41515543
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40827392
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.39734377
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39463789
126Glycerolipid metabolism_Homo sapiens_hsa005610.38920188
127beta-Alanine metabolism_Homo sapiens_hsa004100.36879511
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36249207
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35841006
130Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32297541
131Dorso-ventral axis formation_Homo sapiens_hsa043200.32194308
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.32053887
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31783731
134Platelet activation_Homo sapiens_hsa046110.29574795
135Oocyte meiosis_Homo sapiens_hsa041140.28919097
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28685734
1372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28103916
138Complement and coagulation cascades_Homo sapiens_hsa046100.27940258
139Metabolic pathways_Homo sapiens_hsa011000.27400348
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.27143117
141MAPK signaling pathway_Homo sapiens_hsa040100.25697804
142Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25234401
143Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24933741
144Rap1 signaling pathway_Homo sapiens_hsa040150.24442141
145Endometrial cancer_Homo sapiens_hsa052130.24374517
146Glioma_Homo sapiens_hsa052140.23268886
147African trypanosomiasis_Homo sapiens_hsa051430.21695330
148VEGF signaling pathway_Homo sapiens_hsa043700.20691429
149Colorectal cancer_Homo sapiens_hsa052100.20162660
150N-Glycan biosynthesis_Homo sapiens_hsa005100.19154478
151Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19061112
152Bile secretion_Homo sapiens_hsa049760.18836104

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