GHRH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the glucagon family of proteins. The encoded preproprotein is produced in the hypothalamus and cleaved to generate the mature factor, known as somatoliberin, which acts to stimulate growth hormone release from the pituitary gland. Variant receptors for somatoliberin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thalamus development (GO:0021794)9.34432756
2substrate-independent telencephalic tangential migration (GO:0021826)8.50470709
3substrate-independent telencephalic tangential interneuron migration (GO:0021843)8.50470709
4ganglion development (GO:0061548)8.40513221
5behavioral response to nicotine (GO:0035095)7.64544948
6spinal cord association neuron differentiation (GO:0021527)7.51073236
7neuron fate commitment (GO:0048663)7.01009700
8activation of MAPKKK activity (GO:0000185)6.88844498
9glycerophospholipid catabolic process (GO:0046475)6.79951020
10regulation of oligodendrocyte differentiation (GO:0048713)6.74236984
11positive regulation of p38MAPK cascade (GO:1900745)6.55875269
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.45627773
13establishment of protein localization to mitochondrial membrane (GO:0090151)6.42392584
14forebrain morphogenesis (GO:0048853)6.38080523
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.30073137
16ATP synthesis coupled proton transport (GO:0015986)6.09023236
17energy coupled proton transport, down electrochemical gradient (GO:0015985)6.09023236
18righting reflex (GO:0060013)5.93318613
19forebrain neuron differentiation (GO:0021879)5.83398519
20regulation of transmission of nerve impulse (GO:0051969)5.80075763
21parturition (GO:0007567)5.57310503
22positive regulation of Notch signaling pathway (GO:0045747)5.28035788
23respiratory electron transport chain (GO:0022904)5.27689687
24cerebellar Purkinje cell layer development (GO:0021680)5.26240821
25electron transport chain (GO:0022900)5.15608641
26startle response (GO:0001964)5.15470164
27type B pancreatic cell development (GO:0003323)5.12092359
28postsynaptic membrane organization (GO:0001941)5.04448703
29positive regulation of glial cell differentiation (GO:0045687)5.02048289
30axonal fasciculation (GO:0007413)5.00849590
31cell differentiation in spinal cord (GO:0021515)4.99114485
32regulation of timing of cell differentiation (GO:0048505)4.90457861
33protein localization to synapse (GO:0035418)4.83157711
34pyrimidine nucleobase catabolic process (GO:0006208)4.76622339
35dentate gyrus development (GO:0021542)4.71004998
36drinking behavior (GO:0042756)4.67172147
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55391435
38neuromuscular process controlling posture (GO:0050884)4.52336522
39positive regulation of neural precursor cell proliferation (GO:2000179)4.46378156
40regulation of development, heterochronic (GO:0040034)4.43837250
41maternal behavior (GO:0042711)4.35450753
42regulation of p38MAPK cascade (GO:1900744)4.31513599
43negative regulation of oligodendrocyte differentiation (GO:0048715)4.24765774
44negative regulation of telomere maintenance (GO:0032205)4.22815266
45somite development (GO:0061053)4.21668865
46neuronal stem cell maintenance (GO:0097150)4.14763553
47atrial cardiac muscle cell action potential (GO:0086014)4.11590049
48response to folic acid (GO:0051593)4.08216253
49inner mitochondrial membrane organization (GO:0007007)4.06571125
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.06156007
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.01424003
52phenylpropanoid metabolic process (GO:0009698)4.00735835
53synaptic transmission, cholinergic (GO:0007271)3.98603722
54cerebral cortex neuron differentiation (GO:0021895)3.97178204
55positive regulation of neuroblast proliferation (GO:0002052)3.96500949
56glandular epithelial cell differentiation (GO:0002067)3.95751876
57regulation of glial cell differentiation (GO:0045685)3.95378911
58myoblast migration (GO:0051451)3.95253999
59regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94043732
60cell fate specification (GO:0001708)3.85964511
61ribosomal small subunit assembly (GO:0000028)3.83104755
62regulation of glutamate secretion (GO:0014048)3.81681621
63olfactory bulb development (GO:0021772)3.81415089
64tongue development (GO:0043586)3.80923984
65synaptic vesicle exocytosis (GO:0016079)3.80831850
66axon extension involved in axon guidance (GO:0048846)3.79912435
67neuron projection extension involved in neuron projection guidance (GO:1902284)3.79912435
68viral transcription (GO:0019083)3.79166389
69ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.77247368
70parental behavior (GO:0060746)3.76078627
71membrane hyperpolarization (GO:0060081)3.75692646
72vocalization behavior (GO:0071625)3.75385898
73uterus development (GO:0060065)3.75242402
74regulation of glutamate receptor signaling pathway (GO:1900449)3.74320525
75negative regulation of potassium ion transport (GO:0043267)3.72179253
76regulation of telomerase activity (GO:0051972)3.71912743
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70225571
78nucleobase catabolic process (GO:0046113)3.68636395
79spinal cord motor neuron differentiation (GO:0021522)3.68067648
80regulation of Notch signaling pathway (GO:0008593)3.64839630
81neuron fate specification (GO:0048665)3.63279150
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63171915
83positive regulation of gliogenesis (GO:0014015)3.62737198
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61757515
85* response to food (GO:0032094)3.59347241
86regulation of protein kinase A signaling (GO:0010738)3.57718967
87opsonization (GO:0008228)3.56591599
88glandular epithelial cell development (GO:0002068)3.56526840
89phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.52885674
90translational termination (GO:0006415)3.50954105
91potassium ion export (GO:0071435)3.50333934
92neuron cell-cell adhesion (GO:0007158)3.46648697
93regulation of telomere maintenance via telomerase (GO:0032210)3.45836879
94negative regulation of Notch signaling pathway (GO:0045746)3.42948783
95response to lithium ion (GO:0010226)3.42936239
96ATP biosynthetic process (GO:0006754)3.41636994
97layer formation in cerebral cortex (GO:0021819)3.40105230
98adult feeding behavior (GO:0008343)3.37959675
99norepinephrine metabolic process (GO:0042415)3.36707894
100phosphatidic acid metabolic process (GO:0046473)3.36438063
101phosphatidic acid biosynthetic process (GO:0006654)3.36438063
102negative regulation of amino acid transport (GO:0051956)3.36289022
103locomotory exploration behavior (GO:0035641)3.35268287
104regulation of vesicle fusion (GO:0031338)3.33676832
105urea cycle (GO:0000050)3.32634140
106urea metabolic process (GO:0019627)3.32634140
107paraxial mesoderm development (GO:0048339)3.31419103
108mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.31391633
109* growth hormone secretion (GO:0030252)3.29813710
110calcium ion-dependent exocytosis (GO:0017156)3.29105106
111pyrimidine dimer repair (GO:0006290)3.23946520
112phosphatidylserine acyl-chain remodeling (GO:0036150)3.22964850
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.21030968
114negative regulation of interleukin-1 beta production (GO:0032691)3.20685405
115adult walking behavior (GO:0007628)3.20329575
116neurotransmitter catabolic process (GO:0042135)3.18859332
117succinate metabolic process (GO:0006105)3.17438196
118hydrogen ion transmembrane transport (GO:1902600)3.16756922
119neuron recognition (GO:0008038)3.15582792
120histone H2A monoubiquitination (GO:0035518)3.14688297
121central nervous system projection neuron axonogenesis (GO:0021952)3.14674400
122response to histamine (GO:0034776)3.14258739
123positive regulation of amino acid transport (GO:0051957)3.13175368
124neuroblast proliferation (GO:0007405)3.12705808
125astrocyte differentiation (GO:0048708)3.11709616
126regulation of respiratory system process (GO:0044065)3.11248774
127genetic imprinting (GO:0071514)3.10346088
128ribosomal small subunit biogenesis (GO:0042274)3.10101343
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09759058
130L-phenylalanine catabolic process (GO:0006559)3.06788860
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.06788860
132gamma-aminobutyric acid signaling pathway (GO:0007214)3.06396969
133limb development (GO:0060173)3.06000572
134appendage development (GO:0048736)3.06000572
135nitrogen cycle metabolic process (GO:0071941)3.04365674
136viral protein processing (GO:0019082)3.03656888
137intracellular protein transmembrane import (GO:0044743)3.03463256
138mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.01066929
139centriole replication (GO:0007099)3.00806042
140reflex (GO:0060004)3.00746924
141exploration behavior (GO:0035640)2.98654774
142potassium ion homeostasis (GO:0055075)2.97847271
143proline transport (GO:0015824)2.96696248
144acrosome reaction (GO:0007340)2.93656602
145* positive regulation of growth hormone secretion (GO:0060124)2.93363212
146maturation of SSU-rRNA (GO:0030490)2.93158153
147behavioral response to cocaine (GO:0048148)2.92602997
148neuronal action potential propagation (GO:0019227)2.92483699
149energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91854547
150ATP hydrolysis coupled proton transport (GO:0015991)2.91854547
151central nervous system neuron differentiation (GO:0021953)2.90966114
152regulation of cellular respiration (GO:0043457)2.89835730
153regulation of neuroblast proliferation (GO:1902692)2.89767265
154regulation of calcium ion-dependent exocytosis (GO:0017158)2.89693839
155positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89645166
156mating behavior (GO:0007617)2.87138397
157female mating behavior (GO:0060180)2.87050784
158regulation of heart rate by cardiac conduction (GO:0086091)2.86832083
159regulation of gliogenesis (GO:0014013)2.86730191
160epoxygenase P450 pathway (GO:0019373)2.85832860
161negative regulation of Ras GTPase activity (GO:0034261)2.83882913
162regulation of female receptivity (GO:0045924)2.83323573
163cellular protein complex disassembly (GO:0043624)2.82421979
164dendrite development (GO:0016358)2.82318655
165activation of protein kinase A activity (GO:0034199)2.81260820
166synaptic vesicle maturation (GO:0016188)2.81208587
167positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80823122
168L-phenylalanine metabolic process (GO:0006558)2.80776589
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.80776589
170CDP-diacylglycerol biosynthetic process (GO:0016024)2.80658264
171negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.79704481
172neurotransmitter transport (GO:0006836)2.78739494
173chaperone-mediated protein transport (GO:0072321)2.78611114
174regulation of membrane repolarization (GO:0060306)2.78469691
175calcium-mediated signaling using intracellular calcium source (GO:0035584)2.77180978
176SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.76231952
177gamma-aminobutyric acid transport (GO:0015812)2.75952692
178creatine metabolic process (GO:0006600)2.75829616
179cellular response to superoxide (GO:0071451)2.75341334
180proton transport (GO:0015992)2.73204591
181opioid receptor signaling pathway (GO:0038003)2.73168503
182regulation of respiratory gaseous exchange (GO:0043576)2.73042602
183purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.72437140
184neurotransmitter secretion (GO:0007269)2.71873673
185negative regulation of acute inflammatory response (GO:0002674)2.71602705
186hydrogen transport (GO:0006818)2.69989112
187negative regulation of neurological system process (GO:0031645)2.69766873
188purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68204594
189intracellular protein transmembrane transport (GO:0065002)2.67308805
190fatty acid elongation (GO:0030497)2.65899214
191protein localization to cilium (GO:0061512)2.64414462
192positive regulation of oligodendrocyte differentiation (GO:0048714)10.9019357

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.52163774
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.72184871
3EZH2_22144423_ChIP-Seq_EOC_Human4.19595522
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12166827
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08099587
6TAF15_26573619_Chip-Seq_HEK293_Human3.00213213
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.86278642
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.85449233
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.81074892
10ERG_21242973_ChIP-ChIP_JURKAT_Human2.60811747
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.59231935
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50808213
13ZNF274_21170338_ChIP-Seq_K562_Hela2.46432425
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40149883
15REST_21632747_ChIP-Seq_MESCs_Mouse2.38235600
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.38169273
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36357809
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36221703
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.34169708
20GBX2_23144817_ChIP-Seq_PC3_Human2.33198994
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25628735
22RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25628735
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22047351
24AR_21572438_ChIP-Seq_LNCaP_Human2.19416194
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.14068105
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08158858
27TP53_20018659_ChIP-ChIP_R1E_Mouse2.05558954
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.05153504
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.00792505
30* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.99632433
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95011477
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91723044
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86753613
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.86119098
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82639733
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.80802327
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.79631046
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.76377707
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76091635
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73686503
41SOX2_16153702_ChIP-ChIP_HESCs_Human1.72547230
42SMAD4_21799915_ChIP-Seq_A2780_Human1.72282097
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70926793
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.69585496
45* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67409290
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64469007
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63752480
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62074879
49BCAT_22108803_ChIP-Seq_LS180_Human1.60625183
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59275683
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59275683
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59275683
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57145972
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57132292
55HTT_18923047_ChIP-ChIP_STHdh_Human1.55922088
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54185442
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53456366
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53228212
59ZFP281_18757296_ChIP-ChIP_E14_Mouse1.53019963
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.52131996
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50510288
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.49869890
63RARB_27405468_Chip-Seq_BRAIN_Mouse1.48072753
64DROSHA_22980978_ChIP-Seq_HELA_Human1.47376651
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.46155500
66P300_19829295_ChIP-Seq_ESCs_Human1.44865049
67BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43467859
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43289225
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41500236
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40393009
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.40085858
72SOX2_21211035_ChIP-Seq_LN229_Gbm1.39467623
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38262633
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38260156
75IRF1_19129219_ChIP-ChIP_H3396_Human1.37175680
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36610970
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36114108
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33813919
79ER_23166858_ChIP-Seq_MCF-7_Human1.24980537
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22612777
81TP53_18474530_ChIP-ChIP_U2OS_Human1.22432286
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21157051
83CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19860754
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18676657
85FUS_26573619_Chip-Seq_HEK293_Human1.17710102
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17641429
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17467280
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17331411
89CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16331491
90EP300_21415370_ChIP-Seq_HL-1_Mouse1.14847956
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.13583430
92SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12204050
93* STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.11766683
94RXR_22108803_ChIP-Seq_LS180_Human1.11479886
95VDR_22108803_ChIP-Seq_LS180_Human1.11255241
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04130218
97TP63_19390658_ChIP-ChIP_HaCaT_Human1.03729362
98JUN_21703547_ChIP-Seq_K562_Human1.03328528
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02668077
100POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02199178
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02097494
102AR_25329375_ChIP-Seq_VCAP_Human1.01868087
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.01809415
104CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99889873
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98526444
106AR_19668381_ChIP-Seq_PC3_Human0.97232211
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95527229
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95527229
109EWS_26573619_Chip-Seq_HEK293_Human0.95376998
110* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94509889
111RUNX2_22187159_ChIP-Seq_PCA_Human0.94065036
112ISL1_27105846_Chip-Seq_CPCs_Mouse0.94031726
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94020946
114WDR5_24793694_ChIP-Seq_LNCAP_Human0.92679123
115RING1B_27294783_Chip-Seq_ESCs_Mouse0.92630314
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92454456
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92055837
118RNF2_27304074_Chip-Seq_NSC_Mouse0.89420890
119CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89340689
120AHR_22903824_ChIP-Seq_MCF-7_Human0.88727469
121WT1_19549856_ChIP-ChIP_CCG9911_Human0.86977091
122ZNF263_19887448_ChIP-Seq_K562_Human0.86890580
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86271052
124* CTCF_27219007_Chip-Seq_Bcells_Human0.86179259
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85924301
126MYC_27129775_Chip-Seq_CORNEA_Mouse0.84516658
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84234751
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.83258519
129POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.83253651
130* TET1_21451524_ChIP-Seq_MESCs_Mouse0.82660041
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82430794
132OCT4_19829295_ChIP-Seq_ESCs_Human0.82124836
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81531102
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80804653
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.80581035
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80140789
137POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.80140789
138SOX3_22085726_ChIP-Seq_NPCs_Mouse0.79936154
139TCF4_22108803_ChIP-Seq_LS180_Human0.79077234
140RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.79010589
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78354563
142SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75807554
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.75481735
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.74199447
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.74042042
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73473007
147* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73100657
148TCF3_18692474_ChIP-Seq_MEFs_Mouse0.72866765
149POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.72778417
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.69387786
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.69259965
152RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.68955266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.01134498
2MP0002163_abnormal_gland_morphology4.60309009
3MP0008789_abnormal_olfactory_epithelium4.31472403
4MP0003122_maternal_imprinting4.15884217
5MP0003880_abnormal_central_pattern3.88160332
6MP0005394_taste/olfaction_phenotype3.74119792
7MP0005499_abnormal_olfactory_system3.74119792
8MP0004859_abnormal_synaptic_plasticity3.45112677
9MP0009046_muscle_twitch3.39468163
10MP0006276_abnormal_autonomic_nervous3.27052414
11MP0002837_dystrophic_cardiac_calcinosis2.91784113
12MP0006292_abnormal_olfactory_placode2.90901378
13MP0010030_abnormal_orbit_morphology2.86534279
14MP0003635_abnormal_synaptic_transmissio2.85413065
15MP0002653_abnormal_ependyma_morphology2.79872274
16MP0004142_abnormal_muscle_tone2.79800593
17MP0002102_abnormal_ear_morphology2.77832969
18MP0001440_abnormal_grooming_behavior2.76924694
19MP0004272_abnormal_basement_membrane2.71156780
20MP0002822_catalepsy2.55183304
21MP0005645_abnormal_hypothalamus_physiol2.42564363
22MP0002064_seizures2.37308884
23MP0001727_abnormal_embryo_implantation2.33106177
24MP0003329_amyloid_beta_deposits2.28469723
25MP0002063_abnormal_learning/memory/cond2.28077097
26MP0009379_abnormal_foot_pigmentation2.23984690
27MP0004145_abnormal_muscle_electrophysio2.23782988
28MP0005167_abnormal_blood-brain_barrier2.22134935
29MP0001501_abnormal_sleep_pattern2.12132229
30MP0002254_reproductive_system_inflammat2.10690558
31MP0009745_abnormal_behavioral_response2.09710258
32MP0004742_abnormal_vestibular_system2.06016885
33MP0002572_abnormal_emotion/affect_behav2.05748536
34MP0005423_abnormal_somatic_nervous2.05110118
35MP0003121_genomic_imprinting1.99548667
36MP0001188_hyperpigmentation1.97763681
37MP0005386_behavior/neurological_phenoty1.95623152
38MP0004924_abnormal_behavior1.95623152
39MP0003690_abnormal_glial_cell1.94472125
40MP0009780_abnormal_chondrocyte_physiolo1.93021884
41MP0002332_abnormal_exercise_endurance1.91405154
42MP0005377_hearing/vestibular/ear_phenot1.89028031
43MP0003878_abnormal_ear_physiology1.89028031
44MP0001486_abnormal_startle_reflex1.81508401
45MP0003123_paternal_imprinting1.81240566
46MP0002272_abnormal_nervous_system1.80725790
47MP0002233_abnormal_nose_morphology1.80379681
48MP0004270_analgesia1.75059284
49MP0002095_abnormal_skin_pigmentation1.73624811
50MP0000604_amyloidosis1.65347044
51MP0000049_abnormal_middle_ear1.61706756
52MP0001270_distended_abdomen1.59161595
53MP0002557_abnormal_social/conspecific_i1.56336706
54MP0008875_abnormal_xenobiotic_pharmacok1.54981822
55MP0001529_abnormal_vocalization1.54719052
56MP0001968_abnormal_touch/_nociception1.53161008
57MP0001485_abnormal_pinna_reflex1.53026615
58MP0004036_abnormal_muscle_relaxation1.51221738
59MP0002638_abnormal_pupillary_reflex1.50050342
60MP0006072_abnormal_retinal_apoptosis1.47060158
61MP0003938_abnormal_ear_development1.46873386
62MP0002067_abnormal_sensory_capabilities1.45237249
63MP0005646_abnormal_pituitary_gland1.44755434
64MP0005623_abnormal_meninges_morphology1.43393942
65MP0000751_myopathy1.41076971
66MP0001293_anophthalmia1.38437766
67MP0005360_urolithiasis1.37159801
68MP0002249_abnormal_larynx_morphology1.33267659
69MP0000778_abnormal_nervous_system1.32623720
70MP0002734_abnormal_mechanical_nocicepti1.32526856
71MP0002876_abnormal_thyroid_physiology1.31649511
72MP0005164_abnormal_response_to1.27206707
73MP0003136_yellow_coat_color1.26260434
74MP0008872_abnormal_physiological_respon1.23370409
75MP0000013_abnormal_adipose_tissue1.19875784
76MP0005085_abnormal_gallbladder_physiolo1.18273470
77MP0005083_abnormal_biliary_tract1.18165638
78MP0006138_congestive_heart_failure1.15822151
79MP0004883_abnormal_blood_vessel1.11453349
80MP0000747_muscle_weakness1.11025130
81MP0005535_abnormal_body_temperature1.10065615
82MP0002160_abnormal_reproductive_system1.09647617
83MP0004133_heterotaxia1.08364585
84MP0002066_abnormal_motor_capabilities/c1.07651541
85MP0005551_abnormal_eye_electrophysiolog1.07040161
86MP0003861_abnormal_nervous_system1.06917957
87MP0002139_abnormal_hepatobiliary_system1.05560054
88MP0001970_abnormal_pain_threshold1.00100056
89MP0002069_abnormal_eating/drinking_beha0.99222539
90MP0002733_abnormal_thermal_nociception0.98369610
91MP0004233_abnormal_muscle_weight0.98197168
92MP0008569_lethality_at_weaning0.96760421
93MP0002184_abnormal_innervation0.94929524
94MP0003755_abnormal_palate_morphology0.94892643
95MP0000026_abnormal_inner_ear0.92558148
96MP0001984_abnormal_olfaction0.92441814
97MP0006036_abnormal_mitochondrial_physio0.91797377
98MP0001905_abnormal_dopamine_level0.91582533
99MP0005332_abnormal_amino_acid0.91474951
100MP0001299_abnormal_eye_distance/0.90114987
101MP0005266_abnormal_metabolism0.90033797
102MP0005058_abnormal_lysosome_morphology0.88826176
103MP0005595_abnormal_vascular_smooth0.88780765
104MP0000631_abnormal_neuroendocrine_gland0.88219150
105MP0002909_abnormal_adrenal_gland0.88011418
106MP0006035_abnormal_mitochondrial_morpho0.87593589
107MP0000955_abnormal_spinal_cord0.86707758
108MP0002090_abnormal_vision0.86579802
109MP0000566_synostosis0.86168079
110MP0008775_abnormal_heart_ventricle0.84867526
111MP0004043_abnormal_pH_regulation0.84489196
112MP0002882_abnormal_neuron_morphology0.84150410
113MP0003638_abnormal_response/metabolism_0.83451716
114MP0002752_abnormal_somatic_nervous0.83088000
115MP0000639_abnormal_adrenal_gland0.82989835
116MP0003634_abnormal_glial_cell0.81739916
117MP0002735_abnormal_chemical_nociception0.81568904
118MP0003937_abnormal_limbs/digits/tail_de0.81270926
119MP0001286_abnormal_eye_development0.80821389
120MP0004215_abnormal_myocardial_fiber0.80344690
121MP0002736_abnormal_nociception_after0.80301113
122MP0004885_abnormal_endolymph0.79644328
123MP0005253_abnormal_eye_physiology0.78873013
124MP0000230_abnormal_systemic_arterial0.78305160
125MP0005409_darkened_coat_color0.78111967
126MP0001943_abnormal_respiration0.76650601
127MP0005379_endocrine/exocrine_gland_phen0.76377740
128MP0004858_abnormal_nervous_system0.75696175
129MP0003942_abnormal_urinary_system0.75403736
130MP0000920_abnormal_myelination0.75295016
131MP0002751_abnormal_autonomic_nervous0.74511158
132MP0000750_abnormal_muscle_regeneration0.74180633
133MP0004085_abnormal_heartbeat0.72937896
134MP0005670_abnormal_white_adipose0.72687464
135MP0005376_homeostasis/metabolism_phenot0.72483234
136MP0005391_vision/eye_phenotype0.72323022
137MP0000678_abnormal_parathyroid_gland0.71832869
138MP0004811_abnormal_neuron_physiology0.70104943
139MP0002152_abnormal_brain_morphology0.69573672
140MP0001502_abnormal_circadian_rhythm0.69353374
141MP0003633_abnormal_nervous_system0.68990805
142MP0002116_abnormal_craniofacial_bone0.66920946
143MP0002234_abnormal_pharynx_morphology0.66681442
144MP0002177_abnormal_outer_ear0.66484447
145MP0003385_abnormal_body_wall0.63194766
146MP0005195_abnormal_posterior_eye0.62481581
147MP0002938_white_spotting0.62473794
148MP0003948_abnormal_gas_homeostasis0.60689953
149MP0003011_delayed_dark_adaptation0.60553220
150MP0005448_abnormal_energy_balance0.59835759

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)8.51702174
2Neoplasm of the adrenal cortex (HP:0100641)7.41037560
3Metaphyseal dysplasia (HP:0100255)6.51509436
4Acute necrotizing encephalopathy (HP:0006965)5.16708427
5Neonatal hypoglycemia (HP:0001998)5.04243357
6Myokymia (HP:0002411)4.94297234
7Abnormal mitochondria in muscle tissue (HP:0008316)4.86042178
8Reticulocytopenia (HP:0001896)4.79910226
9Diastasis recti (HP:0001540)4.58988534
10Abnormality of DNA repair (HP:0003254)4.46862782
11Acute encephalopathy (HP:0006846)4.37473376
12Progressive macrocephaly (HP:0004481)4.28248092
13Chorioretinal atrophy (HP:0000533)4.12322736
14Mitochondrial inheritance (HP:0001427)4.01731051
15Abnormal pancreas size (HP:0012094)4.00688324
16Polyphagia (HP:0002591)4.00559974
17Abnormality of the parathyroid morphology (HP:0011766)3.98423736
18Abnormality of cells of the erythroid lineage (HP:0012130)3.87275426
19Palpitations (HP:0001962)3.78566257
20Adrenal hypoplasia (HP:0000835)3.74256458
21Pendular nystagmus (HP:0012043)3.61993565
22Neoplasm of the adrenal gland (HP:0100631)3.57959016
23Epidermoid cyst (HP:0200040)3.53936356
24Hypokinesia (HP:0002375)3.52731959
25Cerebral edema (HP:0002181)3.40516138
26Oligomenorrhea (HP:0000876)3.35634475
27Abnormal number of erythroid precursors (HP:0012131)3.33069329
28Prolonged QT interval (HP:0001657)3.26448156
29Abnormality of the labia minora (HP:0012880)3.25174747
30Muscle hypertrophy of the lower extremities (HP:0008968)3.24237260
31Atonic seizures (HP:0010819)3.20428700
32Enlarged kidneys (HP:0000105)3.19325210
33Aplasia/Hypoplasia of the sternum (HP:0006714)3.18873014
34Increased CSF lactate (HP:0002490)3.17841783
35Deep palmar crease (HP:0006191)3.16263783
36Overgrowth (HP:0001548)3.14599174
37Hepatocellular necrosis (HP:0001404)3.11601684
38Oligodactyly (hands) (HP:0001180)3.11399537
39Menstrual irregularities (HP:0000858)3.08849068
40Growth hormone excess (HP:0000845)3.08639971
41Growth hormone deficiency (HP:0000824)3.06750531
42Athetosis (HP:0002305)3.05088722
43Duplicated collecting system (HP:0000081)2.98061470
44Abnormal eating behavior (HP:0100738)2.95693282
45Septo-optic dysplasia (HP:0100842)2.92297031
46Epileptic encephalopathy (HP:0200134)2.86485213
47Optic nerve hypoplasia (HP:0000609)2.84250941
48Abnormality of the renal collecting system (HP:0004742)2.83442539
49Visual hallucinations (HP:0002367)2.83002142
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81836903
51Leukodystrophy (HP:0002415)2.81684223
52Oligodactyly (HP:0012165)2.79807396
53Abdominal situs inversus (HP:0003363)2.79508050
54Abnormality of abdominal situs (HP:0011620)2.79508050
55Myotonia (HP:0002486)2.76696931
56Frequent falls (HP:0002359)2.75117616
57Germ cell neoplasia (HP:0100728)2.74846764
58Ankle clonus (HP:0011448)2.74807241
59Ectopic kidney (HP:0000086)2.74542738
60Impaired vibration sensation in the lower limbs (HP:0002166)2.68617090
61Anterior segment dysgenesis (HP:0007700)2.65697962
62Papilledema (HP:0001085)2.63040320
63Horseshoe kidney (HP:0000085)2.62869928
64Hypoglycemic seizures (HP:0002173)2.61236131
65Facial hemangioma (HP:0000329)2.57183124
66Respiratory failure (HP:0002878)2.55422415
67Tachypnea (HP:0002789)2.52944026
68Hypoventilation (HP:0002791)2.46191282
69Renal dysplasia (HP:0000110)2.46143893
70Infantile muscular hypotonia (HP:0008947)2.44684179
71Calf muscle hypertrophy (HP:0008981)2.42666010
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.42665699
73Epiphyseal dysplasia (HP:0002656)2.42288527
74Colon cancer (HP:0003003)2.40637687
75Posterior subcapsular cataract (HP:0007787)2.38206967
76Narrow nasal bridge (HP:0000446)2.37928754
77Muscle stiffness (HP:0003552)2.37612224
78Duplication of thumb phalanx (HP:0009942)2.37508017
79Synostosis involving the elbow (HP:0003938)2.36179736
80Humeroradial synostosis (HP:0003041)2.36179736
81High anterior hairline (HP:0009890)2.36019086
82Truncal ataxia (HP:0002078)2.35698906
83Esophageal atresia (HP:0002032)2.34858584
84Hepatic necrosis (HP:0002605)2.34590249
85Abnormality of the metopic suture (HP:0005556)2.34483666
86Rib fusion (HP:0000902)2.34465168
87Pancreatic fibrosis (HP:0100732)2.33314313
88Anxiety (HP:0000739)2.31221584
89Optic disc pallor (HP:0000543)2.30843665
90Focal seizures (HP:0007359)2.30692973
91Aqueductal stenosis (HP:0002410)2.29923839
92Hyperlipoproteinemia (HP:0010980)2.29472030
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28755286
94Double outlet right ventricle (HP:0001719)2.26976125
95Congenital malformation of the right heart (HP:0011723)2.26976125
96X-linked dominant inheritance (HP:0001423)2.26641970
97Progressive cerebellar ataxia (HP:0002073)2.26272620
98Progressive inability to walk (HP:0002505)2.24523687
99Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24293032
100Anophthalmia (HP:0000528)2.22198491
101Diminished movement (HP:0002374)2.20003257
102Increased corneal curvature (HP:0100692)2.19484034
103Keratoconus (HP:0000563)2.19484034
104Supernumerary spleens (HP:0009799)2.18471801
105Gait imbalance (HP:0002141)2.15344147
106Hypsarrhythmia (HP:0002521)2.13058204
107Generalized tonic-clonic seizures (HP:0002069)2.12951602
108Left ventricular hypertrophy (HP:0001712)2.12126561
109Absent thumb (HP:0009777)2.10764200
110Lactic acidosis (HP:0003128)2.10296296
111EEG with generalized epileptiform discharges (HP:0011198)2.10218240
112Exercise intolerance (HP:0003546)2.10085625
113Impulsivity (HP:0100710)2.08393783
114Termporal pattern (HP:0011008)2.07849822
115Insidious onset (HP:0003587)2.07849822
116Hyperventilation (HP:0002883)2.07593165
117Abnormal hair whorl (HP:0010721)2.07010512
118Abnormality of the antihelix (HP:0009738)2.06377672
119Absence seizures (HP:0002121)2.06174000
120Cerebral hemorrhage (HP:0001342)2.05420666
121Poor suck (HP:0002033)2.03861143
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03290036
123Epileptiform EEG discharges (HP:0011182)2.02984022
124Poikiloderma (HP:0001029)2.01954206
125Type II lissencephaly (HP:0007260)2.01937547
126Spastic gait (HP:0002064)2.00841273
127Abnormality of midbrain morphology (HP:0002418)1.99394547
128Molar tooth sign on MRI (HP:0002419)1.99394547
129Failure to thrive in infancy (HP:0001531)1.98986911
130Poor coordination (HP:0002370)1.98586959
131Abnormal EKG (HP:0003115)1.98130945
132Sensory axonal neuropathy (HP:0003390)1.98006357
133Abnormality of the aortic arch (HP:0012303)1.95594465
134Aplasia/Hypoplasia of the spleen (HP:0010451)1.95387425
135Brushfield spots (HP:0001088)1.93976641
136Asplenia (HP:0001746)1.91814523
137Cervical subluxation (HP:0003308)1.91310039
138Buphthalmos (HP:0000557)1.90588752
139Psychosis (HP:0000709)1.89651399
140Supranuclear gaze palsy (HP:0000605)1.89184202
141Deep venous thrombosis (HP:0002625)1.86794742
142Hypercalcemia (HP:0003072)1.86474868
143Congenital primary aphakia (HP:0007707)1.86011349
144Absent rod-and cone-mediated responses on ERG (HP:0007688)1.85723903
145Abnormality of pain sensation (HP:0010832)1.85304390
146Impaired pain sensation (HP:0007328)1.85304390
147Cerebellar dysplasia (HP:0007033)1.83306563
148Tubulointerstitial fibrosis (HP:0005576)1.82911777
149Pheochromocytoma (HP:0002666)1.81183371
150Dysmetria (HP:0001310)1.78834446
151Opisthotonus (HP:0002179)1.77373136
152CNS hypomyelination (HP:0003429)1.75394559
153Rimmed vacuoles (HP:0003805)1.75196671
154Agitation (HP:0000713)1.73679640
155Abolished electroretinogram (ERG) (HP:0000550)1.72135967
156Horizontal nystagmus (HP:0000666)1.72067594
157Scanning speech (HP:0002168)1.71700745
158Medial flaring of the eyebrow (HP:0010747)1.71239519
159Abnormal biliary tract physiology (HP:0012439)1.71233911
160Bile duct proliferation (HP:0001408)1.71233911
161Clonus (HP:0002169)1.71153898
162Forearm undergrowth (HP:0009821)1.70902996
163Short thumb (HP:0009778)1.70797469
164Abnormal rod and cone electroretinograms (HP:0008323)1.69389126
165Depression (HP:0000716)1.69010686
166Absent radius (HP:0003974)1.68902982
167Esotropia (HP:0000565)1.68885838
168Generalized hypotonia (HP:0001290)1.68055104
169Abnormality of the pubic bones (HP:0003172)1.67724609
170Nephrogenic diabetes insipidus (HP:0009806)1.67218170
171Atrial fibrillation (HP:0005110)1.66270457
172Chromsome breakage (HP:0040012)1.65954319
173Infertility (HP:0000789)1.65515252
174Hypercalciuria (HP:0002150)1.65455904
175Macroglossia (HP:0000158)1.65370780
176Diaphragmatic weakness (HP:0009113)1.65348451
177Autoamputation (HP:0001218)1.64704625
178Absent septum pellucidum (HP:0001331)1.64492717
179Postural tremor (HP:0002174)1.64391240
180Hemiplegia (HP:0002301)1.63271127
181Hypoplasia of the ulna (HP:0003022)1.62799282
182Delayed gross motor development (HP:0002194)1.61461149
183Sleep apnea (HP:0010535)1.61162692
184Neuroendocrine neoplasm (HP:0100634)1.61025666
185Microtia (HP:0008551)1.59119843
186Vaginal atresia (HP:0000148)1.59084090
187Neoplasm of the liver (HP:0002896)1.58818023
188Triphalangeal thumb (HP:0001199)1.58556600
189Aplasia involving forearm bones (HP:0009822)1.58339635
190Absent forearm bone (HP:0003953)1.58339635
191Intestinal atresia (HP:0011100)1.57605900
192Holoprosencephaly (HP:0001360)1.57466726
193Optic nerve coloboma (HP:0000588)1.56513564
194Aganglionic megacolon (HP:0002251)1.55984465
195Hydronephrosis (HP:0000126)1.55960188

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.76585170
2NTRK34.02709083
3MAP3K123.81352813
4NTRK23.59455351
5MST1R3.39805307
6MAP3K43.36619196
7TYRO33.06504408
8NTRK12.91519739
9MARK12.51874393
10LATS22.49124686
11MUSK2.35974366
12EPHB22.35293292
13TAOK12.30379027
14IRAK32.29615440
15MINK12.24376025
16DYRK22.13015823
17PINK11.99813431
18MAP3K91.96361035
19CASK1.91851179
20PAK31.82882635
21MAP4K21.81096242
22MAP2K41.80489945
23UHMK11.76927786
24FES1.76904148
25FER1.73751091
26ARAF1.70277687
27PNCK1.63897218
28MARK21.60264779
29ICK1.53901360
30TNK21.51116900
31CAMK41.47888579
32LIMK11.46932577
33CAMKK11.45842823
34ADRBK21.40949412
35CAMK1D1.40516904
36DDR21.39505870
37MOS1.33145966
38EPHA41.31875942
39NME11.30737374
40MET1.25678989
41DYRK1B1.24812425
42TNIK1.23770975
43CAMK2A1.18985832
44BCR1.17117188
45CAMK11.14513010
46MAP3K21.14159367
47PAK61.13621295
48ADRBK11.12262535
49STK161.11909262
50MAP3K101.10578550
51SIK11.09445681
52CDK51.08838147
53FGR1.07395768
54STK38L1.05702736
55MYLK1.05230794
56CAMK1G1.05126247
57PHKG11.04334844
58PHKG21.04334844
59MAP3K71.04048458
60STK391.02632322
61TLK11.01529814
62PLK20.99839374
63DAPK30.98054773
64MAP2K70.88423219
65CSNK1G30.86453535
66CSNK1G20.86277216
67MAP3K110.83953899
68TSSK60.82435573
69ROCK20.82131936
70CAMK2B0.78135056
71MATK0.77418695
72DAPK10.76868496
73SIK30.76543434
74INSRR0.75437773
75SGK30.74791156
76GRK10.74620684
77NEK20.74525157
78CSNK1A1L0.74438423
79KSR20.74342372
80WNK40.71491003
81EPHA30.69157322
82PRKCE0.68684196
83FGFR10.66259578
84CDK11A0.66130772
85GRK60.65718633
86CAMK2D0.64840264
87FGFR20.64520900
88STK240.64354317
89PRKCZ0.63854832
90CAMK2G0.63666952
91PRKCH0.62874648
92DYRK1A0.61849261
93ZAK0.61456536
94OXSR10.60587772
95GRK70.59103709
96DAPK20.58391475
97SIK20.58284659
98RIPK40.57301294
99GRK50.56821571
100EGFR0.56078443
101TTN0.55905746
102BTK0.55353687
103ERBB20.55239759
104PRKCG0.54385486
105RPS6KA60.53516821
106MAPK150.51600876
107FYN0.51479257
108PKN10.51127574
109ABL20.51033396
110PDGFRA0.50634746
111PKN20.50300520
112NEK60.49951495
113LRRK20.49746231
114WNK10.48255821
115BRSK10.48226847
116SGK10.48164278
117PTK60.46944496
118MKNK20.46686951
119PDPK10.46669850
120CDC42BPA0.46320625
121PRKCA0.45766780
122RPS6KL10.45177118
123RPS6KC10.45177118
124CSNK1G10.45131577
125MAPK70.44555877
126PRKACG0.44246292
127ERBB30.44047947
128PRKACA0.43884498
129SRC0.43454299
130MAP2K10.43361917
131PRKAA10.42559714
132KSR10.41853653
133STK110.41649325
134RPS6KA30.41301787
135PRKG10.40701044
136MAPKAPK50.39756953
137CSNK1E0.39603811
138CDK140.39260685
139CAMKK20.38525083
140PDK10.37037722
141MAPK130.36356864
142CDK150.36242608
143MAPK40.36174789
144PRKD20.35949898
145BCKDK0.35125663
146PRKD10.35043592
147PRKCD0.34579716
148CDK180.32772361
149CSNK1A10.32373019
150CDK190.31954168
151RAF10.31349261
152ROCK10.31334111
153AKT10.29852492
154FLT30.29580854
155SGK2230.28819213
156SGK4940.28819213

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.10622650
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005924.37529314
3Linoleic acid metabolism_Homo sapiens_hsa005914.03176999
4Parkinsons disease_Homo sapiens_hsa050124.01767977
5Alzheimers disease_Homo sapiens_hsa050103.34540228
6Basal cell carcinoma_Homo sapiens_hsa052172.91117999
7Notch signaling pathway_Homo sapiens_hsa043302.83775177
8Huntingtons disease_Homo sapiens_hsa050162.81001651
9Nicotine addiction_Homo sapiens_hsa050332.77287740
10Cardiac muscle contraction_Homo sapiens_hsa042602.72500887
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.72118895
12Hedgehog signaling pathway_Homo sapiens_hsa043402.56764861
13GABAergic synapse_Homo sapiens_hsa047272.41272520
14Arachidonic acid metabolism_Homo sapiens_hsa005902.21096254
15Collecting duct acid secretion_Homo sapiens_hsa049662.11348869
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00772991
17Phototransduction_Homo sapiens_hsa047441.88877550
18Regulation of autophagy_Homo sapiens_hsa041401.86146789
19Morphine addiction_Homo sapiens_hsa050321.82065308
20VEGF signaling pathway_Homo sapiens_hsa043701.81146696
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79127503
22Synaptic vesicle cycle_Homo sapiens_hsa047211.77293067
23Fanconi anemia pathway_Homo sapiens_hsa034601.72987989
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68532827
25Pyruvate metabolism_Homo sapiens_hsa006201.66509870
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.62885167
27Renin secretion_Homo sapiens_hsa049241.60521380
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58107284
29p53 signaling pathway_Homo sapiens_hsa041151.57359621
30Vibrio cholerae infection_Homo sapiens_hsa051101.55975033
31Circadian entrainment_Homo sapiens_hsa047131.49814040
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46133806
33Long-term depression_Homo sapiens_hsa047301.43212108
34Glutamatergic synapse_Homo sapiens_hsa047241.39788329
35Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35707312
36Long-term potentiation_Homo sapiens_hsa047201.32842104
37Taste transduction_Homo sapiens_hsa047421.32551696
38MAPK signaling pathway_Homo sapiens_hsa040101.31126302
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28152721
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27757353
41Insulin secretion_Homo sapiens_hsa049111.25194892
42Peroxisome_Homo sapiens_hsa041461.22251047
43Fatty acid elongation_Homo sapiens_hsa000621.20891335
44Salivary secretion_Homo sapiens_hsa049701.18602764
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.18178189
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.16935890
47Dopaminergic synapse_Homo sapiens_hsa047281.13294874
48Serotonergic synapse_Homo sapiens_hsa047261.12787829
49Gastric acid secretion_Homo sapiens_hsa049711.12325806
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.12122457
51Olfactory transduction_Homo sapiens_hsa047401.09973001
52Galactose metabolism_Homo sapiens_hsa000521.09830165
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09402052
54Nitrogen metabolism_Homo sapiens_hsa009101.09117362
55FoxO signaling pathway_Homo sapiens_hsa040681.06549763
56Sulfur metabolism_Homo sapiens_hsa009201.00275115
57Arginine and proline metabolism_Homo sapiens_hsa003301.00024287
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98883491
59Protein export_Homo sapiens_hsa030600.98668429
60Arginine biosynthesis_Homo sapiens_hsa002200.96826604
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96316009
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94972841
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93444072
64Gap junction_Homo sapiens_hsa045400.93367595
65GnRH signaling pathway_Homo sapiens_hsa049120.93165687
66Estrogen signaling pathway_Homo sapiens_hsa049150.91857909
67Graft-versus-host disease_Homo sapiens_hsa053320.91801965
68Amphetamine addiction_Homo sapiens_hsa050310.89800031
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89296693
70Phenylalanine metabolism_Homo sapiens_hsa003600.89228886
71Cholinergic synapse_Homo sapiens_hsa047250.88961995
72Propanoate metabolism_Homo sapiens_hsa006400.88661970
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88520882
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88422003
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88069335
76Calcium signaling pathway_Homo sapiens_hsa040200.86684374
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82257551
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.81922692
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81238008
80Bile secretion_Homo sapiens_hsa049760.80999744
81Nucleotide excision repair_Homo sapiens_hsa034200.80876785
82Dilated cardiomyopathy_Homo sapiens_hsa054140.80619023
83Asthma_Homo sapiens_hsa053100.80364014
84Oxytocin signaling pathway_Homo sapiens_hsa049210.79573642
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77353440
86Cocaine addiction_Homo sapiens_hsa050300.76473230
87Glycerolipid metabolism_Homo sapiens_hsa005610.71908846
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71650288
89Thyroid hormone synthesis_Homo sapiens_hsa049180.71190730
90Prion diseases_Homo sapiens_hsa050200.70243022
91Ras signaling pathway_Homo sapiens_hsa040140.68216018
92Caffeine metabolism_Homo sapiens_hsa002320.67755135
93Phagosome_Homo sapiens_hsa041450.67148479
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65750856
95Fatty acid metabolism_Homo sapiens_hsa012120.65150314
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64515355
97Rheumatoid arthritis_Homo sapiens_hsa053230.63117354
98Tyrosine metabolism_Homo sapiens_hsa003500.62876276
99Hippo signaling pathway_Homo sapiens_hsa043900.62309941
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61568609
101Butanoate metabolism_Homo sapiens_hsa006500.61207678
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.58791977
103Wnt signaling pathway_Homo sapiens_hsa043100.55849300
104Axon guidance_Homo sapiens_hsa043600.55293339
105Chemical carcinogenesis_Homo sapiens_hsa052040.53838549
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53738104
107Complement and coagulation cascades_Homo sapiens_hsa046100.53604588
108Sulfur relay system_Homo sapiens_hsa041220.51926905
109Prolactin signaling pathway_Homo sapiens_hsa049170.49306653
110Alcoholism_Homo sapiens_hsa050340.47214299
111cAMP signaling pathway_Homo sapiens_hsa040240.47040043
112Proteasome_Homo sapiens_hsa030500.46574662
113African trypanosomiasis_Homo sapiens_hsa051430.45211763
114Glucagon signaling pathway_Homo sapiens_hsa049220.44416831
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44251820
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43487409
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43477022
118Ether lipid metabolism_Homo sapiens_hsa005650.43446873
119Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42497478
120Carbon metabolism_Homo sapiens_hsa012000.41228346
121Glioma_Homo sapiens_hsa052140.40638354
122Melanogenesis_Homo sapiens_hsa049160.39964413
123Ribosome_Homo sapiens_hsa030100.39360346
124Salmonella infection_Homo sapiens_hsa051320.38721272
125RNA polymerase_Homo sapiens_hsa030200.38519651
126Dorso-ventral axis formation_Homo sapiens_hsa043200.38197397
127PPAR signaling pathway_Homo sapiens_hsa033200.38177773
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.36702763
129Tryptophan metabolism_Homo sapiens_hsa003800.35107221
130Endometrial cancer_Homo sapiens_hsa052130.33250044
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32919775
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32607740
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31594908
134Fatty acid degradation_Homo sapiens_hsa000710.28910520
135Metabolic pathways_Homo sapiens_hsa011000.28495916
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27294156
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26492020
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26158052
139Ovarian steroidogenesis_Homo sapiens_hsa049130.25420393
140Bladder cancer_Homo sapiens_hsa052190.25390903
141RNA transport_Homo sapiens_hsa030130.25255918
142Starch and sucrose metabolism_Homo sapiens_hsa005000.25071747
143Type II diabetes mellitus_Homo sapiens_hsa049300.24666961
144Pathways in cancer_Homo sapiens_hsa052000.24168042
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23724061
146Pancreatic secretion_Homo sapiens_hsa049720.23564592
147Thyroid cancer_Homo sapiens_hsa052160.23332649
148Oocyte meiosis_Homo sapiens_hsa041140.23266142
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.23033440
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.22844151

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