GHR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)6.94557073
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.65743140
3L-phenylalanine catabolic process (GO:0006559)6.65743140
4L-phenylalanine metabolic process (GO:0006558)6.38386631
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.38386631
6aromatic amino acid family catabolic process (GO:0009074)5.92660758
7epoxygenase P450 pathway (GO:0019373)5.71210035
8omega-hydroxylase P450 pathway (GO:0097267)5.56740453
9alpha-linolenic acid metabolic process (GO:0036109)5.36218803
10glyoxylate metabolic process (GO:0046487)5.31974069
11lysine metabolic process (GO:0006553)5.30009548
12lysine catabolic process (GO:0006554)5.30009548
13cysteine metabolic process (GO:0006534)5.28418599
14tryptophan catabolic process (GO:0006569)5.26143932
15indole-containing compound catabolic process (GO:0042436)5.26143932
16indolalkylamine catabolic process (GO:0046218)5.26143932
17kynurenine metabolic process (GO:0070189)5.11255035
18sulfur amino acid catabolic process (GO:0000098)5.06006581
19fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04041049
20tryptophan metabolic process (GO:0006568)5.01187889
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.99755350
22bile acid biosynthetic process (GO:0006699)4.94889424
23complement activation, alternative pathway (GO:0006957)4.84700017
24ethanol metabolic process (GO:0006067)4.77179183
25homocysteine metabolic process (GO:0050667)4.69895762
26oxidative demethylation (GO:0070989)4.58701706
27urea metabolic process (GO:0019627)4.54769042
28urea cycle (GO:0000050)4.54769042
29serine family amino acid catabolic process (GO:0009071)4.51846465
30amino-acid betaine metabolic process (GO:0006577)4.48046152
31peptidyl-glutamic acid carboxylation (GO:0017187)4.39290094
32protein carboxylation (GO:0018214)4.39290094
33fatty acid beta-oxidation (GO:0006635)4.39207008
34regulation of protein activation cascade (GO:2000257)4.37586282
35bile acid metabolic process (GO:0008206)4.31779902
36negative regulation of fibrinolysis (GO:0051918)4.29101172
37aromatic amino acid family metabolic process (GO:0009072)4.28719586
38triglyceride homeostasis (GO:0070328)4.26080260
39acylglycerol homeostasis (GO:0055090)4.26080260
40fatty acid oxidation (GO:0019395)4.23020645
41regulation of triglyceride catabolic process (GO:0010896)4.22329559
42tyrosine metabolic process (GO:0006570)4.22041390
43nitrogen cycle metabolic process (GO:0071941)4.21512791
44acetyl-CoA metabolic process (GO:0006084)4.21507003
45alpha-amino acid catabolic process (GO:1901606)4.20264523
46regulation of complement activation (GO:0030449)4.17524206
47lipid oxidation (GO:0034440)4.14710687
48positive regulation of fatty acid beta-oxidation (GO:0032000)4.14617858
49cellular ketone body metabolic process (GO:0046950)4.13172795
50short-chain fatty acid metabolic process (GO:0046459)4.11625891
51plasma lipoprotein particle clearance (GO:0034381)4.09743543
52regulation of fibrinolysis (GO:0051917)4.08028586
53drug transmembrane transport (GO:0006855)4.07770189
54fatty acid catabolic process (GO:0009062)4.03724070
55cellular amino acid catabolic process (GO:0009063)4.00241910
56high-density lipoprotein particle remodeling (GO:0034375)4.00223962
57urate metabolic process (GO:0046415)3.91115053
58S-adenosylmethionine metabolic process (GO:0046500)3.90212740
59biotin metabolic process (GO:0006768)3.87966090
60branched-chain amino acid catabolic process (GO:0009083)3.87184796
61monocarboxylic acid catabolic process (GO:0072329)3.86594890
62low-density lipoprotein particle clearance (GO:0034383)3.84256691
63cellular modified amino acid catabolic process (GO:0042219)3.81521956
64coenzyme catabolic process (GO:0009109)3.80237125
65* valine metabolic process (GO:0006573)3.77918889
66indolalkylamine metabolic process (GO:0006586)3.76875193
67organic acid catabolic process (GO:0016054)3.75626738
68carboxylic acid catabolic process (GO:0046395)3.75626738
69aspartate family amino acid catabolic process (GO:0009068)3.72962945
70positive regulation of lipid catabolic process (GO:0050996)3.71742453
71* 2-oxoglutarate metabolic process (GO:0006103)3.70428427
72ethanol oxidation (GO:0006069)3.69507479
73glutamate metabolic process (GO:0006536)3.69263108
74fatty acid transmembrane transport (GO:1902001)3.69017911
75uronic acid metabolic process (GO:0006063)3.67723640
76glucuronate metabolic process (GO:0019585)3.67723640
77serine family amino acid metabolic process (GO:0009069)3.66743243
78positive regulation of fatty acid oxidation (GO:0046321)3.66464252
79carnitine metabolic process (GO:0009437)3.63518747
80blood coagulation, intrinsic pathway (GO:0007597)3.63085657
81reverse cholesterol transport (GO:0043691)3.61597952
82plasma lipoprotein particle remodeling (GO:0034369)3.60221149
83protein-lipid complex remodeling (GO:0034368)3.60221149
84macromolecular complex remodeling (GO:0034367)3.60221149
85benzene-containing compound metabolic process (GO:0042537)3.59607044
86* branched-chain amino acid metabolic process (GO:0009081)3.57052621
87ketone body metabolic process (GO:1902224)3.55426977
88drug catabolic process (GO:0042737)3.54930763
89regulation of cholesterol homeostasis (GO:2000188)3.53830731
90phospholipid homeostasis (GO:0055091)3.52742873
91amine catabolic process (GO:0009310)3.51253212
92cellular biogenic amine catabolic process (GO:0042402)3.51253212
93arginine metabolic process (GO:0006525)3.50324928
94bile acid and bile salt transport (GO:0015721)3.49850573
95cellular glucuronidation (GO:0052695)3.49171651
96regulation of sequestering of triglyceride (GO:0010889)3.47168097
97regulation of fatty acid beta-oxidation (GO:0031998)3.46168764
98regulation of cholesterol esterification (GO:0010872)3.45274557
99phenylpropanoid metabolic process (GO:0009698)3.44716033
100muscle filament sliding (GO:0030049)3.38647074
101actin-myosin filament sliding (GO:0033275)3.38647074
102negative regulation of cholesterol transport (GO:0032375)3.38602205
103negative regulation of sterol transport (GO:0032372)3.38602205
104regulation of skeletal muscle contraction (GO:0014819)3.38132144
105triglyceride catabolic process (GO:0019433)3.37626571
106glycine metabolic process (GO:0006544)3.37064965
107phospholipid efflux (GO:0033700)3.36800018
108neutral lipid catabolic process (GO:0046461)3.35551124
109acylglycerol catabolic process (GO:0046464)3.35551124
110primary alcohol metabolic process (GO:0034308)3.35187700
111positive regulation of glycolytic process (GO:0045821)3.34498448
112xenobiotic catabolic process (GO:0042178)3.32731662
113drug metabolic process (GO:0017144)3.30201956
114dicarboxylic acid biosynthetic process (GO:0043650)3.28295902
115amino acid salvage (GO:0043102)3.27561932
116L-methionine salvage (GO:0071267)3.27561932
117L-methionine biosynthetic process (GO:0071265)3.27561932
118cytolysis (GO:0019835)3.26094941
119drug transport (GO:0015893)3.25751112
120fibrinolysis (GO:0042730)3.25654232
121carnitine shuttle (GO:0006853)3.23943961
122fatty acid homeostasis (GO:0055089)3.13299526
123response to nitrosative stress (GO:0051409)3.10792008
124arginine catabolic process (GO:0006527)3.05256826
125NADH metabolic process (GO:0006734)3.04982786
126regulation of plasminogen activation (GO:0010755)3.01142084
127imidazole-containing compound metabolic process (GO:0052803)2.98886716
128primary alcohol catabolic process (GO:0034310)2.98301564
129regulation of lipoprotein metabolic process (GO:0050746)2.97300755
130alkaloid metabolic process (GO:0009820)2.94375072
131brown fat cell differentiation (GO:0050873)2.93970643
132positive regulation of lipoprotein lipase activity (GO:0051006)2.92163420
133positive regulation of triglyceride lipase activity (GO:0061365)2.92163420
134negative regulation of protein activation cascade (GO:2000258)2.90387910
135carnitine transport (GO:0015879)2.88426616
136amino-acid betaine transport (GO:0015838)2.88426616
137regulation of hexokinase activity (GO:1903299)2.86212080

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.91537623
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.33093989
3RXR_22158963_ChIP-Seq_LIVER_Mouse7.32106411
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.22493095
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.87290643
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.34208954
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.38514594
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91787376
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.80867999
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.46163298
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.96994697
12CLOCK_20551151_ChIP-Seq_293T_Human2.78333182
13* GBX2_23144817_ChIP-Seq_PC3_Human2.33139892
14VDR_22108803_ChIP-Seq_LS180_Human2.27870620
15IGF1R_20145208_ChIP-Seq_DFB_Human2.11126061
16EZH2_22144423_ChIP-Seq_EOC_Human2.03428681
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95557601
18TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93161222
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90233800
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89736770
21ZNF274_21170338_ChIP-Seq_K562_Hela1.87955747
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86261193
23GATA1_22025678_ChIP-Seq_K562_Human1.82817516
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81786772
25ER_23166858_ChIP-Seq_MCF-7_Human1.74237634
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73833333
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.65362995
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43344781
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.41763771
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.40725555
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39966261
32TAF15_26573619_Chip-Seq_HEK293_Human1.35310453
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33259255
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32171253
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31135403
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29192746
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.28223338
38CBP_20019798_ChIP-Seq_JUKART_Human1.26973469
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26973469
40SMAD4_21799915_ChIP-Seq_A2780_Human1.26398325
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25671546
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.24441985
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24135642
44P300_19829295_ChIP-Seq_ESCs_Human1.23867934
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23521078
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22945332
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21679657
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19664717
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19446287
50* AR_25329375_ChIP-Seq_VCAP_Human1.19071091
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19013251
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18362613
53* STAT3_23295773_ChIP-Seq_U87_Human1.17800983
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.17738271
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17513156
56* TCF4_23295773_ChIP-Seq_U87_Human1.16156477
57* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15951415
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15889860
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14137299
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12341071
61ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11879793
62TCF4_22108803_ChIP-Seq_LS180_Human1.11792008
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.10583455
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08676755
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07576947
66* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07442451
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07360399
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07360399
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05979219
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05766745
71FUS_26573619_Chip-Seq_HEK293_Human1.04178563
72NANOG_19829295_ChIP-Seq_ESCs_Human1.03986663
73SOX2_19829295_ChIP-Seq_ESCs_Human1.03986663
74* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02810289
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02763160
76GATA4_25053715_ChIP-Seq_YYC3_Human1.02595567
77OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01406605
78* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00931385
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.00397477
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.00283564
81HTT_18923047_ChIP-ChIP_STHdh_Human1.00186278
82* ESR1_21235772_ChIP-Seq_MCF-7_Human0.99222741
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99130215
84* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97741986
85FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97388272
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.97388272
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.96845010
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95768754
89PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95766207
90PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95690134
91AR_21572438_ChIP-Seq_LNCaP_Human0.95328780
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.95230533
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94371691
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92539382
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92330694
96FOXO3_23340844_ChIP-Seq_DLD1_Human0.91241895
97FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91133605
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91007798
99* RUNX2_22187159_ChIP-Seq_PCA_Human0.89998494
100* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89553374
101* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89528947
102P53_22387025_ChIP-Seq_ESCs_Mouse0.89463155
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87529825
104PHF8_20622853_ChIP-Seq_HELA_Human0.87297192
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86971552
106RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86860779
107SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86824687
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.86546648
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.86546648
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.86129010
111STAT3_18555785_Chip-Seq_ESCs_Mouse0.86123992
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85556173
113HOXB7_26014856_ChIP-Seq_BT474_Human0.85533519
114* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84350548
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.82512498
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81577679
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80701674
118* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.75436749
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75204344
120SOX2_20726797_ChIP-Seq_SW620_Human0.72396544
121BCAT_22108803_ChIP-Seq_LS180_Human0.72083758
122ZNF263_19887448_ChIP-Seq_K562_Human0.71645187
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69863349
124CJUN_26792858_Chip-Seq_BT549_Human0.68403950
125* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67370246
126* FOXA1_25552417_ChIP-Seq_VCAP_Human0.66517773
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64809198
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.64374352
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.63974897
130GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.62977031
131IRF8_22096565_ChIP-ChIP_GC-B_Human0.62668973
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.62449032
133* EP300_21415370_ChIP-Seq_HL-1_Mouse0.62383204
134TP63_17297297_ChIP-ChIP_HaCaT_Human0.62148817
135* PIAS1_25552417_ChIP-Seq_VCAP_Human0.62142217
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60657400
137* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.60501497
138* GATA3_24758297_ChIP-Seq_MCF-7_Human0.60474776
139FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60033050
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59214625
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58962078
142GATA2_21666600_ChIP-Seq_HMVEC_Human0.58248970
143GATA1_19941826_ChIP-Seq_K562_Human0.57264569
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.56843151
145LXR_22292898_ChIP-Seq_THP-1_Human0.56807566
146CEBPB_22108803_ChIP-Seq_LS180_Human0.56036854
147AR_20517297_ChIP-Seq_VCAP_Human0.55722960
148FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54338772
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53852333
150NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53545476
151CBP_21632823_ChIP-Seq_H3396_Human0.52895335
152GATA6_25053715_ChIP-Seq_YYC3_Human0.52639708
153RARA_24833708_ChIP-Seq_LIVER_Mouse0.52339685
154GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.52050671
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.51570970
156PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51472421
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.51117793
158CDX2_22108803_ChIP-Seq_LS180_Human0.50831625
159GATA2_19941826_ChIP-Seq_K562_Human0.50705942
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49395146
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.48448950
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48267773
163TP63_23658742_ChIP-Seq_EP156T_Human0.47920045
164* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.46179122
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.45846305

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.16657023
2MP0005360_urolithiasis6.84042007
3MP0005365_abnormal_bile_salt5.55020829
4MP0005085_abnormal_gallbladder_physiolo5.22430962
5MP0003646_muscle_fatigue4.47548272
6MP0008875_abnormal_xenobiotic_pharmacok4.08693456
7MP0003252_abnormal_bile_duct3.62099650
8MP0004145_abnormal_muscle_electrophysio3.56508147
9* MP0010329_abnormal_lipoprotein_level3.31317136
10MP0003806_abnormal_nucleotide_metabolis3.21056170
11MP0005332_abnormal_amino_acid2.93210501
12MP0003195_calcinosis2.90609602
13MP0005670_abnormal_white_adipose2.86750402
14MP0000751_myopathy2.54061227
15MP0005083_abnormal_biliary_tract2.46839398
16MP0001666_abnormal_nutrient_absorption2.37679472
17MP0003191_abnormal_cellular_cholesterol2.32649864
18MP0004019_abnormal_vitamin_homeostasis2.26219448
19MP0000749_muscle_degeneration2.24464348
20* MP0002118_abnormal_lipid_homeostasis2.22071682
21MP0009840_abnormal_foam_cell2.17979104
22MP0002138_abnormal_hepatobiliary_system2.04048878
23MP0000609_abnormal_liver_physiology2.02478215
24MP0004130_abnormal_muscle_cell1.94265442
25MP0005666_abnormal_adipose_tissue1.90516161
26MP0004036_abnormal_muscle_relaxation1.88889470
27MP0002837_dystrophic_cardiac_calcinosis1.87898369
28MP0009643_abnormal_urine_homeostasis1.78687842
29MP0003705_abnormal_hypodermis_morpholog1.73042674
30MP0008438_abnormal_cutaneous_collagen1.69220780
31* MP0005319_abnormal_enzyme/_coenzyme1.66937248
32MP0002638_abnormal_pupillary_reflex1.58916561
33MP0003868_abnormal_feces_composition1.53770036
34MP0004215_abnormal_myocardial_fiber1.52755929
35MP0001764_abnormal_homeostasis1.51224842
36MP0003186_abnormal_redox_activity1.49815449
37MP0005584_abnormal_enzyme/coenzyme_acti1.49807473
38MP0002106_abnormal_muscle_physiology1.49558159
39MP0005620_abnormal_muscle_contractility1.48596571
40MP0005369_muscle_phenotype1.43562168
41MP0008775_abnormal_heart_ventricle1.43552174
42MP0002108_abnormal_muscle_morphology1.43247677
43MP0004084_abnormal_cardiac_muscle1.41643184
44MP0004043_abnormal_pH_regulation1.39824355
45MP0002971_abnormal_brown_adipose1.38116393
46MP0004087_abnormal_muscle_fiber1.36987907
47MP0002332_abnormal_exercise_endurance1.36583482
48MP0005375_adipose_tissue_phenotype1.31793327
49MP0004185_abnormal_adipocyte_glucose1.30980084
50MP0001756_abnormal_urination1.23484316
51MP0000759_abnormal_skeletal_muscle1.23084457
52MP0002078_abnormal_glucose_homeostasis1.21156260
53MP0000013_abnormal_adipose_tissue1.16603708
54* MP0005334_abnormal_fat_pad1.16305350
55MP0000747_muscle_weakness1.12713622
56MP0005275_abnormal_skin_tensile1.09723784
57MP0004484_altered_response_of1.09713961
58MP0001544_abnormal_cardiovascular_syste1.06870623
59MP0005385_cardiovascular_system_phenoty1.06870623
60MP0000372_irregular_coat_pigmentation1.06223711
61MP0003950_abnormal_plasma_membrane1.06209436
62MP0005220_abnormal_exocrine_pancreas1.05761359
63MP0005551_abnormal_eye_electrophysiolog1.05393005
64* MP0005535_abnormal_body_temperature1.05316746
65MP0008872_abnormal_physiological_respon1.04815801
66* MP0005636_abnormal_mineral_homeostasis1.03875326
67MP0006276_abnormal_autonomic_nervous1.03432265
68* MP0000598_abnormal_liver_morphology1.03399213
69MP0006036_abnormal_mitochondrial_physio1.03111917
70MP0002972_abnormal_cardiac_muscle1.02294795
71MP0005084_abnormal_gallbladder_morpholo0.99943087
72MP0005451_abnormal_body_composition0.94772437
73MP0009115_abnormal_fat_cell0.94414561
74MP0005503_abnormal_tendon_morphology0.94350057
75MP0010368_abnormal_lymphatic_system0.93332205
76MP0005187_abnormal_penis_morphology0.93133647
77MP0005167_abnormal_blood-brain_barrier0.91357907
78MP0009697_abnormal_copulation0.91314351
79MP0002254_reproductive_system_inflammat0.90190050
80* MP0002876_abnormal_thyroid_physiology0.88298565
81MP0001986_abnormal_taste_sensitivity0.87734614
82MP0005379_endocrine/exocrine_gland_phen0.86571787
83MP0000003_abnormal_adipose_tissue0.86331296
84MP0005448_abnormal_energy_balance0.84820901
85MP0002102_abnormal_ear_morphology0.84330339
86* MP0009642_abnormal_blood_homeostasis0.83744742
87MP0005646_abnormal_pituitary_gland0.83037892
88MP0009763_increased_sensitivity_to0.81637074
89MP0002136_abnormal_kidney_physiology0.81017058
90MP0009780_abnormal_chondrocyte_physiolo0.79716109
91MP0002970_abnormal_white_adipose0.79708091
92MP0002168_other_aberrant_phenotype0.78513790
93MP0001501_abnormal_sleep_pattern0.77273607
94MP0009764_decreased_sensitivity_to0.77069376
95MP0000427_abnormal_hair_cycle0.76388777
96MP0003011_delayed_dark_adaptation0.75980132
97MP0003879_abnormal_hair_cell0.75811638
98MP0002928_abnormal_bile_duct0.74767124
99MP0000750_abnormal_muscle_regeneration0.72726023
100MP0000230_abnormal_systemic_arterial0.72501197
101MP0004272_abnormal_basement_membrane0.70736769
102MP0001765_abnormal_ion_homeostasis0.69461266
103MP0004147_increased_porphyrin_level0.69061071
104MP0003690_abnormal_glial_cell0.67841520
105* MP0003959_abnormal_lean_body0.67495645
106MP0003137_abnormal_impulse_conducting0.67388837
107MP0005376_homeostasis/metabolism_phenot0.67047415
108MP0004142_abnormal_muscle_tone0.66844646
109* MP0003953_abnormal_hormone_level0.64826474
110MP0005058_abnormal_lysosome_morphology0.64668750
111MP0001984_abnormal_olfaction0.64636559
112MP0003656_abnormal_erythrocyte_physiolo0.64383510
113MP0009384_cardiac_valve_regurgitation0.64355577
114MP0002060_abnormal_skin_morphology0.64148581
115MP0002127_abnormal_cardiovascular_syste0.63958336
116MP0000604_amyloidosis0.63712449
117* MP0008469_abnormal_protein_level0.62882322
118MP0003724_increased_susceptibility_to0.62660877
119MP0005408_hypopigmentation0.62474169
120MP0004085_abnormal_heartbeat0.62452169
121MP0002282_abnormal_trachea_morphology0.62139519
122MP0008961_abnormal_basal_metabolism0.62038876
123* MP0001944_abnormal_pancreas_morphology0.58413954
124MP0002796_impaired_skin_barrier0.55773714
125* MP0001661_extended_life_span0.54480683
126MP0005266_abnormal_metabolism0.53515315
127* MP0005647_abnormal_sex_gland0.52756299
128MP0005452_abnormal_adipose_tissue0.50474427
129MP0003300_gastrointestinal_ulcer0.50334580
130MP0004264_abnormal_extraembryonic_tissu0.50136672
131MP0002896_abnormal_bone_mineralization0.49885348
132MP0001881_abnormal_mammary_gland0.49649512
133MP0009765_abnormal_xenobiotic_induced0.49364554
134MP0005395_other_phenotype0.49019155
135MP0002295_abnormal_pulmonary_circulatio0.47927485
136MP0000538_abnormal_urinary_bladder0.45449229
137MP0005330_cardiomyopathy0.45202908
138MP0002269_muscular_atrophy0.44064813
139MP0009053_abnormal_anal_canal0.43823123
140MP0002909_abnormal_adrenal_gland0.43369291
141MP0006138_congestive_heart_failure0.43155346
142MP0000639_abnormal_adrenal_gland0.42428878
143MP0003638_abnormal_response/metabolism_0.40822521
144MP0005595_abnormal_vascular_smooth0.39966610

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.03734613
2Muscle fiber inclusion bodies (HP:0100299)5.81994242
3Intrahepatic cholestasis (HP:0001406)5.77418462
4Nemaline bodies (HP:0003798)5.70123999
5Deep venous thrombosis (HP:0002625)5.56011991
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.52207924
7Xanthomatosis (HP:0000991)5.45395041
8Hyperglycinuria (HP:0003108)4.97994346
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.92824771
10Ketosis (HP:0001946)4.84743036
11Complement deficiency (HP:0004431)4.80973633
12Hypoglycemic coma (HP:0001325)4.76516429
13Prolonged partial thromboplastin time (HP:0003645)4.60795640
14Abnormality of serine family amino acid metabolism (HP:0010894)4.57514552
15Abnormality of glycine metabolism (HP:0010895)4.57514552
16Hyperlipoproteinemia (HP:0010980)4.50292675
17Ketoacidosis (HP:0001993)4.43737618
18Hyperglycinemia (HP:0002154)4.40405291
19Hypobetalipoproteinemia (HP:0003563)4.40284641
20Hyperammonemia (HP:0001987)4.37683999
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33269991
22Exercise-induced myalgia (HP:0003738)4.27903928
23Type 1 muscle fiber predominance (HP:0003803)4.27271192
24Muscle hypertrophy of the lower extremities (HP:0008968)4.08330385
25Epidermoid cyst (HP:0200040)4.01027741
26Abnormality of fatty-acid metabolism (HP:0004359)3.93861266
27Calf muscle hypertrophy (HP:0008981)3.86452029
28Hypolipoproteinemia (HP:0010981)3.85719581
29Hypoalphalipoproteinemia (HP:0003233)3.85084389
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.66261247
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.63930489
32Abnormality of the common coagulation pathway (HP:0010990)3.61613095
33Gout (HP:0001997)3.60753690
34Exercise-induced muscle cramps (HP:0003710)3.58287915
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.57334939
36Abnormality of purine metabolism (HP:0004352)3.53253544
37Joint hemorrhage (HP:0005261)3.48255515
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.44596438
39Abnormality of complement system (HP:0005339)3.42182009
40Abnormality of the intrinsic pathway (HP:0010989)3.34982363
41Fat malabsorption (HP:0002630)3.32608686
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26539129
43Abnormality of alanine metabolism (HP:0010916)3.26539129
44Hyperalaninemia (HP:0003348)3.26539129
45Rhabdomyolysis (HP:0003201)3.18723077
46Hypoglycemic seizures (HP:0002173)3.17583521
47Distal arthrogryposis (HP:0005684)3.17303720
48Abnormality of nucleobase metabolism (HP:0010932)3.13698418
49Generalized aminoaciduria (HP:0002909)3.10049626
50Abnormality of dicarboxylic acid metabolism (HP:0010995)3.07487795
51Dicarboxylic aciduria (HP:0003215)3.07487795
52Abnormality of methionine metabolism (HP:0010901)3.07026353
53Conjugated hyperbilirubinemia (HP:0002908)2.99888494
54Delayed CNS myelination (HP:0002188)2.99248036
55Hypercholesterolemia (HP:0003124)2.98898211
56Skin nodule (HP:0200036)2.93101493
57Abnormality of serum amino acid levels (HP:0003112)2.86758490
58Metabolic acidosis (HP:0001942)2.85777302
59Increased purine levels (HP:0004368)2.85119045
60Hyperuricemia (HP:0002149)2.85119045
61Abnormality of the calf musculature (HP:0001430)2.83848459
62Hyporeflexia of lower limbs (HP:0002600)2.83279444
63Hyperinsulinemic hypoglycemia (HP:0000825)2.79883742
64Myocardial infarction (HP:0001658)2.79115206
65Muscle fiber splitting (HP:0003555)2.74311549
66Proximal tubulopathy (HP:0000114)2.73742099
67Glomerulonephritis (HP:0000099)2.70707455
68Hydroxyprolinuria (HP:0003080)2.68069871
69Abnormality of proline metabolism (HP:0010907)2.68069871
70Hyperbilirubinemia (HP:0002904)2.67728996
71Absent phalangeal crease (HP:0006109)2.64109169
72EMG: myopathic abnormalities (HP:0003458)2.63556772
73Hepatocellular carcinoma (HP:0001402)2.63452374
74Lethargy (HP:0001254)2.60810529
75Rimmed vacuoles (HP:0003805)2.60154860
76Hyperglycemia (HP:0003074)2.57393052
77Late onset (HP:0003584)2.57008284
78Myopathic facies (HP:0002058)2.44284724
79Enlarged kidneys (HP:0000105)2.42396452
80Systemic lupus erythematosus (HP:0002725)2.40911819
81Steatorrhea (HP:0002570)2.40479665
82Round ear (HP:0100830)2.39627301
83Pancreatitis (HP:0001733)2.38810404
84Frequent falls (HP:0002359)2.37706162
85Ulnar deviation of the wrist (HP:0003049)2.36884174
86Symptomatic seizures (HP:0011145)2.35590893
87Hypertriglyceridemia (HP:0002155)2.34977766
88Abnormality of pyrimidine metabolism (HP:0004353)2.34588166
89Fair hair (HP:0002286)2.34247781
90Oligomenorrhea (HP:0000876)2.33865296
91Vomiting (HP:0002013)2.31353490
92Myoglobinuria (HP:0002913)2.31189299
93Vascular calcification (HP:0004934)2.30906113
94Difficulty running (HP:0009046)2.30743099
95Cerebral palsy (HP:0100021)2.30204245
96Alkalosis (HP:0001948)2.29722679
97Neck muscle weakness (HP:0000467)2.28805832
98Cerebral edema (HP:0002181)2.27331662
99Abnormal cartilage morphology (HP:0002763)2.26623478
100Cardiovascular calcification (HP:0011915)2.22579966
101Abnormality of the renal cortex (HP:0011035)2.21912459
102Bundle branch block (HP:0011710)2.21637603
103Heart block (HP:0012722)2.19431407
104Myotonia (HP:0002486)2.18329519
105Irritability (HP:0000737)2.17467545
106Abnormal finger flexion creases (HP:0006143)2.14645543
107Mitral stenosis (HP:0001718)2.13858534
108Abnormality of urine glucose concentration (HP:0011016)2.13725758
109Glycosuria (HP:0003076)2.13725758
110Hemorrhage of the eye (HP:0011885)2.11057109
111Neonatal onset (HP:0003623)2.07681442
112Asymmetric septal hypertrophy (HP:0001670)2.07441337
113Insulin resistance (HP:0000855)2.06841528
114Spastic diplegia (HP:0001264)2.05861578
115Sensorimotor neuropathy (HP:0007141)2.04980535
116Abnormality of skeletal muscle fiber size (HP:0012084)2.04538982
117Nephritis (HP:0000123)2.03019680
118Abnormal gallbladder morphology (HP:0012437)2.02025583
119Infantile muscular hypotonia (HP:0008947)2.00504299
120Malnutrition (HP:0004395)1.99966058
121Nausea (HP:0002018)1.99891220
122Spontaneous abortion (HP:0005268)1.96992929
123Brushfield spots (HP:0001088)1.96145220
124Atrioventricular block (HP:0001678)1.94666724
125Bile duct proliferation (HP:0001408)1.94426518
126Abnormal biliary tract physiology (HP:0012439)1.94426518
127Congenital stationary night blindness (HP:0007642)1.93451435
128Renal cortical cysts (HP:0000803)1.92755010
129Increased variability in muscle fiber diameter (HP:0003557)1.92469629
130Gowers sign (HP:0003391)1.92243726
131Abnormal atrioventricular conduction (HP:0005150)1.91670629
132Cholelithiasis (HP:0001081)1.91152455
133Acanthosis nigricans (HP:0000956)1.89738792
134Abnormal enzyme/coenzyme activity (HP:0012379)1.89134476
135Pigmentary retinal degeneration (HP:0001146)1.87187659
136Esophageal varix (HP:0002040)1.84525671
137Arthropathy (HP:0003040)1.83980248
138Increased muscle lipid content (HP:0009058)1.83900623
139Hepatic necrosis (HP:0002605)1.83140900
140Nephrolithiasis (HP:0000787)1.82852250
141Subaortic stenosis (HP:0001682)1.82711074
142Abnormality of the left ventricular outflow tract (HP:0011103)1.82711074
143Increased serum pyruvate (HP:0003542)1.81720041
144Rickets (HP:0002748)1.80746095
145Insulin-resistant diabetes mellitus (HP:0000831)1.79792062
146Hypokalemic alkalosis (HP:0001949)1.78294141
147Opisthotonus (HP:0002179)1.76872680
148Pancreatic cysts (HP:0001737)1.76163171
149Amyloidosis (HP:0011034)1.72752472
150Abnormality of endocrine pancreas physiology (HP:0012093)1.71694505
151Abnormality of the pancreatic islet cells (HP:0006476)1.71694505
152Hypochromic microcytic anemia (HP:0004840)1.70801407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.97593850
2SIK14.30111815
3INSRR3.81759462
4ERN13.70052540
5TRIB33.38529309
6FGFR42.99088877
7CAMK1D2.47006039
8FRK2.35225591
9BMPR1B2.34509616
10MAPKAPK32.28890698
11MST1R2.19305130
12LATS12.17509665
13WNK42.05363943
14ADRBK21.99294392
15WNK31.97729724
16PKN21.90020209
17GRK11.88569064
18FLT31.78457949
19MAP4K21.77886626
20PDK41.72714397
21PDK31.72714397
22MUSK1.68369710
23CAMK1G1.67435547
24TAOK31.65641060
25ERBB41.51720739
26STK38L1.49346696
27NEK91.45446732
28PRKAA21.42845012
29PIK3CG1.42634375
30RIPK11.35668541
31FGFR21.35383045
32TRPM71.35028345
33PDGFRA1.34407809
34ACVR1B1.33010446
35MET1.32461689
36PTK61.31075198
37MAPK111.29341137
38EPHA31.27682435
39MAPK131.20453884
40MAP2K41.18803975
41TIE11.16754359
42TLK11.14938653
43CAMK11.11945010
44MAP2K61.11756326
45ADRBK11.10532968
46NLK1.09679988
47PINK11.04902171
48FGFR31.04258461
49PIK3CA1.00785474
50TGFBR10.98241859
51PDK20.98027766
52PRKAA10.96803962
53CASK0.93047559
54MAP3K70.92907224
55MAP3K30.92758696
56TGFBR20.92690822
57OXSR10.91634994
58CAMKK20.91359321
59JAK10.90714903
60ERBB30.88732485
61IRAK30.86067809
62ABL20.85657030
63TTN0.84209729
64MYLK0.81748212
65STK390.81190941
66PTK20.80717349
67PRKCE0.79993775
68MAP2K30.79441747
69PRKG10.79429020
70GSK3A0.78901839
71MAPK150.77589053
72MAP3K40.77425786
73SGK30.76311989
74FER0.73946570
75MARK10.73196575
76TXK0.72064474
77PRKACA0.71487360
78TYK20.69855404
79LIMK10.68359894
80NUAK10.68111804
81MAP2K10.67623696
82LMTK20.67163820
83OBSCN0.67058076
84PRKACG0.66922550
85ZAK0.66429226
86CDK60.65951669
87KDR0.65642827
88PKN10.62160785
89PAK30.61930860
90SGK2230.61537653
91SGK4940.61537653
92PRKCG0.61428919
93EPHB10.61027099
94MTOR0.60555419
95MAP3K20.59809651
96RET0.59752139
97SGK20.59509861
98GRK50.59283876
99PDPK10.57038858
100TNIK0.56828865
101EPHB20.56745857
102PRKCH0.54250861
103DYRK1B0.54116602
104DAPK20.52878468
105CAMK2D0.52876169
106PRKCZ0.52733323
107AKT30.51521261
108IRAK10.51429127
109PRKACB0.49471329
110DDR20.49208823
111KIT0.47300210
112* JAK20.46262186
113CAMK2A0.46167824
114MAPK70.46010031
115LATS20.44658646
116CAMK40.43626312
117NME10.43276850
118PHKG20.42577652
119PHKG10.42577652
120ERBB20.42095845
121PRKD10.41516517
122MAPK120.40888692
123TNK20.40659505
124PTK2B0.39437288
125GRK70.38004064
126RPS6KA30.37918373
127FGFR10.37650368
128STK30.37645759
129* IGF1R0.37627728
130MAPKAPK50.37425613
131AKT20.36333607
132PRKCA0.34504358
133IRAK20.34455336
134STK380.34226658
135NEK10.33600551
136MAP3K100.33562953
137NTRK30.33538529
138MAPK40.33368320
139MAP2K20.33153482
140CSK0.32655038
141PAK20.31841975
142DMPK0.31565159
143PDGFRB0.31205399
144ABL10.30386616
145PRKD30.30318346
146PDK10.30180937
147CSNK1D0.30068362
148CAMK2G0.28349837
149TBK10.28183256
150ROCK10.28088680
151NTRK10.27183352
152MAP3K60.27164444
153CDK90.24467361

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.74413624
2Nitrogen metabolism_Homo sapiens_hsa009103.15900802
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.03875838
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95726605
5Fatty acid degradation_Homo sapiens_hsa000712.85400505
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.76576642
7Propanoate metabolism_Homo sapiens_hsa006402.76333544
8Tryptophan metabolism_Homo sapiens_hsa003802.70680982
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68309343
10Arginine biosynthesis_Homo sapiens_hsa002202.56546087
11Butanoate metabolism_Homo sapiens_hsa006502.47764021
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37072506
13PPAR signaling pathway_Homo sapiens_hsa033202.35129642
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26945900
15Fatty acid metabolism_Homo sapiens_hsa012122.26922273
16Peroxisome_Homo sapiens_hsa041462.23953971
17Complement and coagulation cascades_Homo sapiens_hsa046102.19830391
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11166228
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09569419
20beta-Alanine metabolism_Homo sapiens_hsa004101.91345824
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79036016
22Pyruvate metabolism_Homo sapiens_hsa006201.75369951
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74701972
24Sulfur metabolism_Homo sapiens_hsa009201.58795633
25Histidine metabolism_Homo sapiens_hsa003401.58781182
26Caffeine metabolism_Homo sapiens_hsa002321.58481926
27Phenylalanine metabolism_Homo sapiens_hsa003601.58230596
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56383603
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55948765
30Chemical carcinogenesis_Homo sapiens_hsa052041.55408753
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53524144
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.53169204
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.48505544
34Selenocompound metabolism_Homo sapiens_hsa004501.48445843
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43341258
36Carbon metabolism_Homo sapiens_hsa012001.39194564
37Tyrosine metabolism_Homo sapiens_hsa003501.38839175
38Bile secretion_Homo sapiens_hsa049761.38334132
39Starch and sucrose metabolism_Homo sapiens_hsa005001.38270208
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.35438376
41Staphylococcus aureus infection_Homo sapiens_hsa051501.34731938
42Fatty acid elongation_Homo sapiens_hsa000621.33454522
43Retinol metabolism_Homo sapiens_hsa008301.33031101
44Fat digestion and absorption_Homo sapiens_hsa049751.30374134
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24075213
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22081819
47Glycerolipid metabolism_Homo sapiens_hsa005611.15098942
48ABC transporters_Homo sapiens_hsa020101.12013707
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09846561
50Biosynthesis of amino acids_Homo sapiens_hsa012301.08707584
51Folate biosynthesis_Homo sapiens_hsa007901.06996808
52Fatty acid biosynthesis_Homo sapiens_hsa000611.04545576
53Lysine degradation_Homo sapiens_hsa003100.98976036
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.98664133
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.96094628
56Vitamin digestion and absorption_Homo sapiens_hsa049770.93178416
57Arginine and proline metabolism_Homo sapiens_hsa003300.90129787
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78958576
59Circadian rhythm_Homo sapiens_hsa047100.74080496
60Steroid biosynthesis_Homo sapiens_hsa001000.72754399
61Vitamin B6 metabolism_Homo sapiens_hsa007500.69921058
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68957989
63Sulfur relay system_Homo sapiens_hsa041220.67830338
64Glutathione metabolism_Homo sapiens_hsa004800.67810923
65Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66380663
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66290691
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.60053662
68Insulin resistance_Homo sapiens_hsa049310.58249961
69Cardiac muscle contraction_Homo sapiens_hsa042600.57437230
70Pentose phosphate pathway_Homo sapiens_hsa000300.53670844
71Dilated cardiomyopathy_Homo sapiens_hsa054140.51632607
72Phototransduction_Homo sapiens_hsa047440.45597726
73Metabolic pathways_Homo sapiens_hsa011000.44877241
74AMPK signaling pathway_Homo sapiens_hsa041520.44066959
75Oxidative phosphorylation_Homo sapiens_hsa001900.41993960
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.39746730
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37894848
78Fructose and mannose metabolism_Homo sapiens_hsa000510.36698342
79Glucagon signaling pathway_Homo sapiens_hsa049220.36315003
80Galactose metabolism_Homo sapiens_hsa000520.34566823
81Parkinsons disease_Homo sapiens_hsa050120.31710691
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31436009
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30519275
84One carbon pool by folate_Homo sapiens_hsa006700.30438977
85Protein digestion and absorption_Homo sapiens_hsa049740.28369185
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28175117
87Prion diseases_Homo sapiens_hsa050200.26715871
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26250370
89Ether lipid metabolism_Homo sapiens_hsa005650.24246310
90* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23346781
91Serotonergic synapse_Homo sapiens_hsa047260.20496671
92Insulin signaling pathway_Homo sapiens_hsa049100.20435076
93Alzheimers disease_Homo sapiens_hsa050100.17417683
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.17241795
95Linoleic acid metabolism_Homo sapiens_hsa005910.16757800
96Renin secretion_Homo sapiens_hsa049240.16365626
97Mineral absorption_Homo sapiens_hsa049780.15968230
98Calcium signaling pathway_Homo sapiens_hsa040200.15253196
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15181982
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11182686
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10589112
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.10579362
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08962478
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.07044588
105Insulin secretion_Homo sapiens_hsa049110.06537486
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04059323
107Renin-angiotensin system_Homo sapiens_hsa046140.03589981
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03253019
109Type II diabetes mellitus_Homo sapiens_hsa049300.03140377
110Oxytocin signaling pathway_Homo sapiens_hsa049210.03127671
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.02437736
112Thyroid hormone synthesis_Homo sapiens_hsa049180.01578988
113Regulation of autophagy_Homo sapiens_hsa04140-0.1176358
114Other glycan degradation_Homo sapiens_hsa00511-0.1086994
115Amoebiasis_Homo sapiens_hsa05146-0.1047469
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0880830
117ECM-receptor interaction_Homo sapiens_hsa04512-0.0770033
118Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0431312
119Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0424560
120Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0379114
121Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0220171
122Lysosome_Homo sapiens_hsa04142-0.0098369

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