GGT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.90374231
2L-phenylalanine catabolic process (GO:0006559)6.90374231
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.62016353
4L-phenylalanine metabolic process (GO:0006558)6.62016353
5aromatic amino acid family catabolic process (GO:0009074)6.20970577
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.87717962
7indole-containing compound catabolic process (GO:0042436)5.68961071
8indolalkylamine catabolic process (GO:0046218)5.68961071
9tryptophan catabolic process (GO:0006569)5.68961071
10kynurenine metabolic process (GO:0070189)5.51167966
11regulation of guanylate cyclase activity (GO:0031282)5.48333129
12tryptophan metabolic process (GO:0006568)5.37510987
13bile acid biosynthetic process (GO:0006699)5.36383093
14urea metabolic process (GO:0019627)5.33464672
15urea cycle (GO:0000050)5.33464672
16high-density lipoprotein particle remodeling (GO:0034375)5.24314767
17positive regulation of respiratory burst (GO:0060267)5.18550577
18cysteine metabolic process (GO:0006534)5.08330544
19sulfur amino acid catabolic process (GO:0000098)5.08204528
20phosphatidylserine acyl-chain remodeling (GO:0036150)4.99149618
21phospholipid efflux (GO:0033700)4.99120396
22glyoxylate metabolic process (GO:0046487)4.98447619
23regulation of triglyceride catabolic process (GO:0010896)4.90064410
24nitrogen cycle metabolic process (GO:0071941)4.88573519
25serine family amino acid catabolic process (GO:0009071)4.88181195
26L-fucose catabolic process (GO:0042355)4.84739525
27fucose catabolic process (GO:0019317)4.84739525
28L-fucose metabolic process (GO:0042354)4.84739525
29negative regulation of fibrinolysis (GO:0051918)4.81660692
30phosphatidylinositol acyl-chain remodeling (GO:0036149)4.79233160
31protein carboxylation (GO:0018214)4.78874933
32peptidyl-glutamic acid carboxylation (GO:0017187)4.78874933
33regulation of fibrinolysis (GO:0051917)4.73993938
34alpha-linolenic acid metabolic process (GO:0036109)4.73753221
35regulation of cholesterol esterification (GO:0010872)4.70897571
36homocysteine metabolic process (GO:0050667)4.70603463
37intestinal absorption (GO:0050892)4.69881090
38bile acid metabolic process (GO:0008206)4.67399923
39amino-acid betaine metabolic process (GO:0006577)4.62741099
40regulation of protein activation cascade (GO:2000257)4.62474713
41complement activation, alternative pathway (GO:0006957)4.57300672
42calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.53183119
43aromatic amino acid family metabolic process (GO:0009072)4.52675021
44reverse cholesterol transport (GO:0043691)4.46159362
45negative regulation of sterol transport (GO:0032372)4.41754263
46negative regulation of cholesterol transport (GO:0032375)4.41754263
47plasma lipoprotein particle remodeling (GO:0034369)4.39645056
48protein-lipid complex remodeling (GO:0034368)4.39645056
49macromolecular complex remodeling (GO:0034367)4.39645056
50triglyceride homeostasis (GO:0070328)4.39627938
51acylglycerol homeostasis (GO:0055090)4.39627938
52imidazole-containing compound metabolic process (GO:0052803)4.38184430
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.35666036
54regulation of complement activation (GO:0030449)4.31284091
55positive regulation of guanylate cyclase activity (GO:0031284)4.30746176
56bile acid and bile salt transport (GO:0015721)4.28986919
57negative regulation of lipase activity (GO:0060192)4.27230324
58drug catabolic process (GO:0042737)4.23563362
59alpha-amino acid catabolic process (GO:1901606)4.22944992
60angiotensin maturation (GO:0002003)4.21896105
61tyrosine metabolic process (GO:0006570)4.19733538
62desmosome organization (GO:0002934)4.16927383
63lysine metabolic process (GO:0006553)4.13608299
64lysine catabolic process (GO:0006554)4.13608299
65fibrinolysis (GO:0042730)4.10692149
66phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.06965939
67regulation of bile acid biosynthetic process (GO:0070857)4.04598893
68amine catabolic process (GO:0009310)4.02688317
69cellular biogenic amine catabolic process (GO:0042402)4.02688317
70indolalkylamine metabolic process (GO:0006586)4.01430187
71glutamate metabolic process (GO:0006536)4.00079677
72sulfate transmembrane transport (GO:1902358)3.97958683
73oligosaccharide biosynthetic process (GO:0009312)3.97769147
74glycine metabolic process (GO:0006544)3.96172152
75cellular ketone body metabolic process (GO:0046950)3.95422538
76plasma lipoprotein particle clearance (GO:0034381)3.95042658
77cholesterol efflux (GO:0033344)3.95007298
78regulation of cholesterol homeostasis (GO:2000188)3.93958573
79phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.93093221
80cellular glucuronidation (GO:0052695)3.91477406
81cellular amino acid catabolic process (GO:0009063)3.90519050
82benzene-containing compound metabolic process (GO:0042537)3.89504870
83serine family amino acid metabolic process (GO:0009069)3.87811311
84cellular modified amino acid catabolic process (GO:0042219)3.83256332
85epoxygenase P450 pathway (GO:0019373)3.82114893
86arginine metabolic process (GO:0006525)3.79777542
87plasma lipoprotein particle assembly (GO:0034377)3.77300931
88coenzyme catabolic process (GO:0009109)3.76862388
89ethanol oxidation (GO:0006069)3.74653013
90vitamin transmembrane transport (GO:0035461)3.74286111
913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.73092897
92purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.73092897
93intestinal cholesterol absorption (GO:0030299)3.72621032
94cholesterol homeostasis (GO:0042632)3.70138587
95axonemal dynein complex assembly (GO:0070286)3.69000945
96positive regulation of lipoprotein lipase activity (GO:0051006)3.67692113
97positive regulation of triglyceride lipase activity (GO:0061365)3.67692113
98fucosylation (GO:0036065)3.65871272
99carnitine metabolic process (GO:0009437)3.64116255
100sterol homeostasis (GO:0055092)3.63149015
101exogenous drug catabolic process (GO:0042738)3.62915851
102short-chain fatty acid metabolic process (GO:0046459)3.61387568
103very-low-density lipoprotein particle assembly (GO:0034379)3.60559178
104ethanol metabolic process (GO:0006067)3.57434380
105serine family amino acid biosynthetic process (GO:0009070)3.55064452
106phosphatidylcholine acyl-chain remodeling (GO:0036151)3.53477197
107linoleic acid metabolic process (GO:0043651)3.52922849
108flavonoid metabolic process (GO:0009812)3.52560849
109primary alcohol catabolic process (GO:0034310)3.52103737
110regulation of cellular extravasation (GO:0002691)3.51237106
111very long-chain fatty acid metabolic process (GO:0000038)3.49475913
112positive regulation of lipid catabolic process (GO:0050996)3.49359409
113glucuronate metabolic process (GO:0019585)3.47080962
114uronic acid metabolic process (GO:0006063)3.47080962
115drug metabolic process (GO:0017144)3.45811967
116carboxylic acid catabolic process (GO:0046395)3.45097181
117organic acid catabolic process (GO:0016054)3.45097181
118regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41477485
119dicarboxylic acid biosynthetic process (GO:0043650)3.41448854
120bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41381565
121ketone body metabolic process (GO:1902224)3.40931422
122establishment of skin barrier (GO:0061436)3.40880150
123multicellular organismal water homeostasis (GO:0050891)3.40681079
124fatty acid elongation (GO:0030497)3.40103651
125blood coagulation, intrinsic pathway (GO:0007597)3.38749309
126low-density lipoprotein particle remodeling (GO:0034374)3.38460482
127regulation of respiratory burst (GO:0060263)3.37182681
128glomerular filtration (GO:0003094)3.35180076
129digestion (GO:0007586)3.34332266
130lipoprotein metabolic process (GO:0042157)3.34018709
131protein-lipid complex assembly (GO:0065005)3.32684416
132intestinal epithelial cell development (GO:0060576)3.28477254
133positive regulation of glycoprotein biosynthetic process (GO:0010560)3.28206857
134sulfate transport (GO:0008272)3.26888256
135transepithelial transport (GO:0070633)3.24402766
136regulation of cGMP biosynthetic process (GO:0030826)3.21845517
137sulfur compound transport (GO:0072348)3.21395028
138epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.20281019
139regulation of systemic arterial blood pressure by hormone (GO:0001990)3.20150940
140regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.20150940
141endocrine process (GO:0050886)3.20150940
142transcytosis (GO:0045056)3.19645885
143cilium or flagellum-dependent cell motility (GO:0001539)3.19112697
144sulfation (GO:0051923)3.17285072
145excretion (GO:0007588)3.16822739
146maintenance of gastrointestinal epithelium (GO:0030277)3.15765884
147auditory receptor cell differentiation (GO:0042491)3.14729309
148phosphatidylserine metabolic process (GO:0006658)3.06389500
149renal system process involved in regulation of blood volume (GO:0001977)3.05551313
150positive regulation of fatty acid beta-oxidation (GO:0032000)3.04513039
151pyrimidine-containing compound transmembrane transport (GO:0072531)3.03555872
152arginine catabolic process (GO:0006527)3.03057346
153cilium movement (GO:0003341)3.02553100
154regulation of water loss via skin (GO:0033561)3.02456618
155regulation of protein glycosylation (GO:0060049)3.01621421
156water homeostasis (GO:0030104)3.00209450
157quinone biosynthetic process (GO:1901663)2.97848472
158regulation of systemic arterial blood pressure (GO:0003073)2.96883447
159O-glycan processing (GO:0016266)2.96147572
160positive regulation of fatty acid oxidation (GO:0046321)2.93727021
161bicarbonate transport (GO:0015701)2.92546146
162epithelial cilium movement (GO:0003351)2.91987588
163phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.91709105
164axoneme assembly (GO:0035082)2.91347602
165antibacterial humoral response (GO:0019731)2.90832005
166glycerol metabolic process (GO:0006071)2.89870762
167fat-soluble vitamin biosynthetic process (GO:0042362)2.89237231
168antimicrobial humoral response (GO:0019730)2.86047827
169renal filtration (GO:0097205)2.85979863
170positive regulation of glycoprotein metabolic process (GO:1903020)2.81184386
171kidney morphogenesis (GO:0060993)2.78671245
172vitamin biosynthetic process (GO:0009110)2.76373447
173receptor guanylyl cyclase signaling pathway (GO:0007168)2.75910332
174positive regulation of fatty acid transport (GO:2000193)2.75889086
175alkaloid metabolic process (GO:0009820)2.75153706
176regulation of cGMP metabolic process (GO:0030823)2.74327842
177primary alcohol metabolic process (GO:0034308)2.72258480
178positive regulation of pseudopodium assembly (GO:0031274)2.71203256
179alditol phosphate metabolic process (GO:0052646)2.69799446
180keratinization (GO:0031424)2.68570946
181phosphatidylcholine metabolic process (GO:0046470)2.66510806
182digestive system process (GO:0022600)2.66364610
183one-carbon compound transport (GO:0019755)2.66044297
184water-soluble vitamin biosynthetic process (GO:0042364)2.63509663
185positive regulation of icosanoid secretion (GO:0032305)2.61455826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.85975487
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.94312167
3TP63_17297297_ChIP-ChIP_HaCaT_Human6.68609573
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.13651510
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.82930260
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.42579758
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.51698381
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.47474980
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.06896141
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.95157267
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.39026725
12VDR_22108803_ChIP-Seq_LS180_Human2.87850639
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.82208510
14ZNF274_21170338_ChIP-Seq_K562_Hela2.59921302
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24792391
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88211498
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85290637
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75572157
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.75082482
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74176822
21GATA1_22025678_ChIP-Seq_K562_Human1.70418526
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.67833615
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61324788
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58957565
25DROSHA_22980978_ChIP-Seq_HELA_Human1.56145239
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52349762
27TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51373255
28NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50986286
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50958849
30FOXA1_21572438_ChIP-Seq_LNCaP_Human1.47861937
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.47487105
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47323343
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.47323343
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.47157011
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44675697
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.43475051
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43258962
38SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42168556
39ER_23166858_ChIP-Seq_MCF-7_Human1.42045036
40GATA4_25053715_ChIP-Seq_YYC3_Human1.40960590
41HTT_18923047_ChIP-ChIP_STHdh_Human1.40675047
42* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.39848572
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39721375
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36620730
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35215868
46TCF4_22108803_ChIP-Seq_LS180_Human1.34322302
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.33848114
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32610854
49CLOCK_20551151_ChIP-Seq_293T_Human1.31669582
50AHR_22903824_ChIP-Seq_MCF-7_Human1.29289006
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.29061420
52SOX9_24532713_ChIP-Seq_HFSC_Mouse1.29014399
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26945042
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.26830399
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26704470
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.25180258
57GBX2_23144817_ChIP-Seq_PC3_Human1.24385101
58NANOG_20526341_ChIP-Seq_ESCs_Human1.24185507
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22349550
60GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.21849768
61NCOR_22424771_ChIP-Seq_293T_Human1.21624670
62RXR_22108803_ChIP-Seq_LS180_Human1.20810947
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.19241830
64BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18488625
65HOXB7_26014856_ChIP-Seq_BT474_Human1.17623357
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16393301
67AR_25329375_ChIP-Seq_VCAP_Human1.15569103
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15518856
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.15287122
70ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13817122
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.13711468
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.13348133
73SOX2_20726797_ChIP-Seq_SW620_Human1.11290320
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10976517
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10432240
76P300_19829295_ChIP-Seq_ESCs_Human1.08732333
77ERA_21632823_ChIP-Seq_H3396_Human1.08137483
78IGF1R_20145208_ChIP-Seq_DFB_Human1.08074183
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07092451
80FOXH1_21741376_ChIP-Seq_ESCs_Human1.06655449
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06547207
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06020164
83CBP_20019798_ChIP-Seq_JUKART_Human1.05982089
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05982089
85MYC_19829295_ChIP-Seq_ESCs_Human1.05616819
86ZNF263_19887448_ChIP-Seq_K562_Human1.04406632
87ETV1_20927104_ChIP-Seq_GIST48_Human1.02888040
88RBPJ_21746931_ChIP-Seq_IB4_Human1.01615203
89EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01306349
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.01143760
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00373957
92RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98987433
93NANOG_19829295_ChIP-Seq_ESCs_Human0.98666971
94SOX2_19829295_ChIP-Seq_ESCs_Human0.98666971
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98515599
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97877016
97KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97597640
98KLF5_25053715_ChIP-Seq_YYC3_Human0.97554294
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97010310
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96761408
101TCF4_23295773_ChIP-Seq_U87_Human0.95595219
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.94707723
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94158551
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92797684
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92056252
106GATA6_25053715_ChIP-Seq_YYC3_Human0.90790143
107* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88308960
108CEBPB_22108803_ChIP-Seq_LS180_Human0.87591876
109BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87056786
110RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86576989
111EGR1_19032775_ChIP-ChIP_M12_Human0.82074802
112SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81957562
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80148170
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79028527
115SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78154555
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74033332
117BCAT_22108803_ChIP-Seq_LS180_Human0.73178770
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.72806510
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72026498
120TP63_23658742_ChIP-Seq_EP156T_Human0.71315600
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69599057
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69257715
123* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67626439
124LXR_22292898_ChIP-Seq_THP-1_Human0.67165946
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.67058425
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.67058425
127* RACK7_27058665_Chip-Seq_MCF-7_Human0.66688308
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66422339
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.66313111
130NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66305282
131NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66305282
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.66002345
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.65164804
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63735947
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.63193754
136FOXA1_25552417_ChIP-Seq_VCAP_Human0.62492745
137GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.62136804
138KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60807627
139TP63_22573176_ChIP-Seq_HFKS_Human0.58662413
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.58106725
141ATF3_27146783_Chip-Seq_COLON_Human0.57870588
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.57278310
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.56853849
144FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56704093
145CTCF_27219007_Chip-Seq_Bcells_Human0.56095154
146RUNX1_27514584_Chip-Seq_MCF-7_Human0.55551087
147FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55196187
148P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.55100786
149CJUN_26792858_Chip-Seq_BT549_Human0.54189134
150* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53727246
151AR_20517297_ChIP-Seq_VCAP_Human0.53102640
152P53_21459846_ChIP-Seq_SAOS-2_Human0.52396531
153TAF2_19829295_ChIP-Seq_ESCs_Human0.52105525
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.51735846
155BCOR_27268052_Chip-Seq_Bcells_Human0.51233073
156FOXM1_26456572_ChIP-Seq_MCF-7_Human0.50080344
157MYC_19915707_ChIP-ChIP_AK7_Human0.49750546
158TCF4_18268006_ChIP-ChIP_LS174T_Human0.48398725
159SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.48248804
160CBP_21632823_ChIP-Seq_H3396_Human0.48240286
161GATA6_21074721_ChIP-Seq_CACO-2_Human0.47847620
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.47781833
163RARB_24833708_ChIP-Seq_LIVER_Mouse0.47576427
164CDX2_22108803_ChIP-Seq_LS180_Human0.47522192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.92797938
2MP0002139_abnormal_hepatobiliary_system6.86217293
3MP0005085_abnormal_gallbladder_physiolo5.63591575
4MP0005365_abnormal_bile_salt5.29760183
5MP0008875_abnormal_xenobiotic_pharmacok4.54308818
6MP0004043_abnormal_pH_regulation4.06193344
7MP0002796_impaired_skin_barrier3.58591294
8MP0003252_abnormal_bile_duct3.35085042
9MP0010234_abnormal_vibrissa_follicle3.10132068
10MP0003806_abnormal_nucleotide_metabolis3.03053070
11MP0010329_abnormal_lipoprotein_level2.96055585
12MP0009840_abnormal_foam_cell2.86986099
13MP0001666_abnormal_nutrient_absorption2.80918563
14MP0004147_increased_porphyrin_level2.69527499
15MP0003195_calcinosis2.55500073
16MP0005451_abnormal_body_composition2.54933738
17MP0002254_reproductive_system_inflammat2.51183129
18MP0003191_abnormal_cellular_cholesterol2.41200231
19MP0004019_abnormal_vitamin_homeostasis2.38053701
20MP0005083_abnormal_biliary_tract2.37564429
21MP0005332_abnormal_amino_acid2.36224120
22MP0001664_abnormal_digestion2.23611676
23MP0010155_abnormal_intestine_physiology2.08866137
24MP0001873_stomach_inflammation2.06038258
25MP0003866_abnormal_defecation2.04174165
26MP0004381_abnormal_hair_follicle2.02283405
27MP0008872_abnormal_physiological_respon1.97008699
28MP0005501_abnormal_skin_physiology1.92711922
29MP0002118_abnormal_lipid_homeostasis1.76362076
30MP0000609_abnormal_liver_physiology1.74856485
31MP0003183_abnormal_peptide_metabolism1.74477562
32MP0003705_abnormal_hypodermis_morpholog1.72262691
33MP0001188_hyperpigmentation1.69344912
34MP0004885_abnormal_endolymph1.64536377
35MP0002138_abnormal_hepatobiliary_system1.63657042
36MP0001501_abnormal_sleep_pattern1.59558032
37MP0002060_abnormal_skin_morphology1.57803743
38MP0001485_abnormal_pinna_reflex1.53390096
39MP0000579_abnormal_nail_morphology1.51078683
40MP0005275_abnormal_skin_tensile1.50486304
41MP0010678_abnormal_skin_adnexa1.48835375
42MP0003868_abnormal_feces_composition1.48370731
43MP0002098_abnormal_vibrissa_morphology1.47939316
44MP0001663_abnormal_digestive_system1.45975647
45MP0001216_abnormal_epidermal_layer1.45269163
46MP0003011_delayed_dark_adaptation1.43902718
47MP0003453_abnormal_keratinocyte_physiol1.40256171
48MP0003941_abnormal_skin_development1.40166519
49MP0005319_abnormal_enzyme/_coenzyme1.39497348
50MP0009379_abnormal_foot_pigmentation1.34165249
51MP0000383_abnormal_hair_follicle1.33850480
52MP0002277_abnormal_respiratory_mucosa1.28260159
53MP0005174_abnormal_tail_pigmentation1.28095214
54MP0009643_abnormal_urine_homeostasis1.23793401
55MP0001764_abnormal_homeostasis1.23767159
56MP0005647_abnormal_sex_gland1.21966232
57MP0000477_abnormal_intestine_morphology1.17113542
58MP0010771_integument_phenotype1.16729317
59MP0005381_digestive/alimentary_phenotyp1.16183643
60MP0009780_abnormal_chondrocyte_physiolo1.15152307
61MP0010386_abnormal_urinary_bladder1.14236332
62MP0000647_abnormal_sebaceous_gland1.14172971
63MP0005584_abnormal_enzyme/coenzyme_acti1.09683886
64MP0005551_abnormal_eye_electrophysiolog1.09406717
65MP0002653_abnormal_ependyma_morphology1.08671550
66MP0000377_abnormal_hair_follicle1.08030388
67MP0000566_synostosis1.07376099
68MP0000230_abnormal_systemic_arterial1.03776696
69MP0000467_abnormal_esophagus_morphology1.02995814
70MP0005310_abnormal_salivary_gland1.01651099
71MP0005367_renal/urinary_system_phenotyp1.01512041
72MP0000516_abnormal_urinary_system1.01512041
73MP0000427_abnormal_hair_cycle0.96507951
74MP0004947_skin_inflammation0.96370515
75MP0009697_abnormal_copulation0.95958384
76MP0000465_gastrointestinal_hemorrhage0.95123260
77MP0005636_abnormal_mineral_homeostasis0.91882094
78MP0005645_abnormal_hypothalamus_physiol0.91880070
79MP0009053_abnormal_anal_canal0.89724364
80MP0009764_decreased_sensitivity_to0.89650250
81MP0001346_abnormal_lacrimal_gland0.89236816
82MP0000470_abnormal_stomach_morphology0.87823836
83MP0003186_abnormal_redox_activity0.87510833
84MP0000678_abnormal_parathyroid_gland0.87285963
85MP0000490_abnormal_crypts_of0.87232859
86MP0005408_hypopigmentation0.86483283
87MP0004782_abnormal_surfactant_physiolog0.81651785
88MP0000462_abnormal_digestive_system0.81630041
89MP0000015_abnormal_ear_pigmentation0.80748333
90MP0002095_abnormal_skin_pigmentation0.79470278
91MP0010352_gastrointestinal_tract_polyps0.78384730
92MP0009931_abnormal_skin_appearance0.78305406
93MP0004185_abnormal_adipocyte_glucose0.78087196
94MP0002876_abnormal_thyroid_physiology0.77144279
95MP0001191_abnormal_skin_condition0.76301252
96MP0000598_abnormal_liver_morphology0.75774803
97MP0005075_abnormal_melanosome_morpholog0.75609920
98MP0003878_abnormal_ear_physiology0.74786053
99MP0005377_hearing/vestibular/ear_phenot0.74786053
100MP0009763_increased_sensitivity_to0.74241131
101MP0001919_abnormal_reproductive_system0.73926201
102MP0004264_abnormal_extraembryonic_tissu0.72933166
103MP0003045_fibrosis0.72911988
104MP0009765_abnormal_xenobiotic_induced0.71752711
105MP0003283_abnormal_digestive_organ0.71514669
106MP0003718_maternal_effect0.70557768
107MP0000604_amyloidosis0.68337593
108MP0002938_white_spotting0.68294020
109MP0001243_abnormal_dermal_layer0.67613755
110MP0002909_abnormal_adrenal_gland0.66412661
111MP0002102_abnormal_ear_morphology0.66380551
112MP0009384_cardiac_valve_regurgitation0.66197315
113MP0003638_abnormal_response/metabolism_0.65402064
114MP0009642_abnormal_blood_homeostasis0.65199574
115MP0003953_abnormal_hormone_level0.64770322
116MP0008469_abnormal_protein_level0.64220539
117MP0005389_reproductive_system_phenotype0.64190298
118MP0005409_darkened_coat_color0.63777241
119MP0002971_abnormal_brown_adipose0.62729638
120MP0001756_abnormal_urination0.62147718
121MP0005166_decreased_susceptibility_to0.61789341
122MP0001968_abnormal_touch/_nociception0.59354615
123MP0000367_abnormal_coat/_hair0.59229188
124MP0003656_abnormal_erythrocyte_physiolo0.58140242
125MP0002638_abnormal_pupillary_reflex0.57517191
126MP0004484_altered_response_of0.57452392
127MP0002136_abnormal_kidney_physiology0.57425594
128MP0000538_abnormal_urinary_bladder0.56439535
129MP0010368_abnormal_lymphatic_system0.54540351
130MP0005220_abnormal_exocrine_pancreas0.54124569
131MP0005376_homeostasis/metabolism_phenot0.51021117
132MP0005084_abnormal_gallbladder_morpholo0.50280471
133MP0005666_abnormal_adipose_tissue0.46913409
134MP0005395_other_phenotype0.45388322
135MP0003724_increased_susceptibility_to0.44866438
136MP0005334_abnormal_fat_pad0.43878949
137MP0003436_decreased_susceptibility_to0.43851090
138MP0005023_abnormal_wound_healing0.43372446
139MP0001340_abnormal_eyelid_morphology0.41940915
140MP0005448_abnormal_energy_balance0.41775495
141MP0005670_abnormal_white_adipose0.41759049
142MP0002078_abnormal_glucose_homeostasis0.41283426
143MP0002132_abnormal_respiratory_system0.40593397
144MP0003329_amyloid_beta_deposits0.39745675
145MP0000762_abnormal_tongue_morphology0.39460162
146MP0001765_abnormal_ion_homeostasis0.39375948
147MP0005187_abnormal_penis_morphology0.36442714
148MP0005266_abnormal_metabolism0.35579169
149MP0003690_abnormal_glial_cell0.34323504
150MP0001881_abnormal_mammary_gland0.33557613

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.80410563
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.53340823
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30439098
4Deep venous thrombosis (HP:0002625)6.21831378
5Xanthomatosis (HP:0000991)5.97977301
6Hyperactive renin-angiotensin system (HP:0000841)5.89687988
7Decreased circulating renin level (HP:0003351)5.85454671
8Hypobetalipoproteinemia (HP:0003563)5.72543114
9Prolonged partial thromboplastin time (HP:0003645)5.71185976
10Hyperlipoproteinemia (HP:0010980)4.93929635
11Abnormality of renin-angiotensin system (HP:0000847)4.87586061
12Metabolic alkalosis (HP:0200114)4.75697907
13Complement deficiency (HP:0004431)4.43019929
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.38407910
15Hypolipoproteinemia (HP:0010981)4.36020822
16Epidermoid cyst (HP:0200040)4.31060690
17Hyperammonemia (HP:0001987)4.20242911
18Hyperglycinemia (HP:0002154)4.14578719
19Hyperglycinuria (HP:0003108)4.07057860
20Fat malabsorption (HP:0002630)4.03971266
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.98399908
22Abnormality of glycine metabolism (HP:0010895)3.94801590
23Abnormality of serine family amino acid metabolism (HP:0010894)3.94801590
24Joint hemorrhage (HP:0005261)3.93091586
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.87215938
26Hypoalphalipoproteinemia (HP:0003233)3.86526459
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.84066936
28Ketosis (HP:0001946)3.70929854
29Abnormality of the common coagulation pathway (HP:0010990)3.70010168
30Conjugated hyperbilirubinemia (HP:0002908)3.69768869
31Hyperaldosteronism (HP:0000859)3.68926561
32Abnormality of chloride homeostasis (HP:0011422)3.62546977
33Absent/shortened dynein arms (HP:0200106)3.62054548
34Dynein arm defect of respiratory motile cilia (HP:0012255)3.62054548
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60557391
36Abnormality of methionine metabolism (HP:0010901)3.58443674
37Chronic bronchitis (HP:0004469)3.50566097
38Abnormality of complement system (HP:0005339)3.45261098
39Hypoglycemic coma (HP:0001325)3.40611892
40Congenital sensorineural hearing impairment (HP:0008527)3.40126689
41Abnormal respiratory epithelium morphology (HP:0012253)3.39474245
42Abnormal respiratory motile cilium morphology (HP:0005938)3.39474245
43Abnormality of the vitamin B12 metabolism (HP:0004341)3.32242514
44Abnormality of vitamin B metabolism (HP:0004340)3.27606002
45Pili torti (HP:0003777)3.15395210
46Abnormal respiratory motile cilium physiology (HP:0012261)3.15055748
47Abnormality of pyrimidine metabolism (HP:0004353)3.11803198
48Abnormal ciliary motility (HP:0012262)3.11766130
49Hypercholesterolemia (HP:0003124)3.10538351
50Abnormality of fatty-acid metabolism (HP:0004359)3.03968157
51Abnormality of the intrinsic pathway (HP:0010989)3.03539665
52Steatorrhea (HP:0002570)3.02197228
53Rhinitis (HP:0012384)3.00213271
54Right ventricular cardiomyopathy (HP:0011663)2.97451488
55Vascular calcification (HP:0004934)2.92410663
56Congenital ichthyosiform erythroderma (HP:0007431)2.85949538
57Hyperbilirubinemia (HP:0002904)2.85568687
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83515578
59Pancreatic cysts (HP:0001737)2.80528210
60Chronic diarrhea (HP:0002028)2.79915549
61Abnormality of nucleobase metabolism (HP:0010932)2.78979978
62Ketoacidosis (HP:0001993)2.76585044
63Malnutrition (HP:0004395)2.76138290
64Abnormality of the renal cortex (HP:0011035)2.74899380
65True hermaphroditism (HP:0010459)2.73926769
66Congenital stationary night blindness (HP:0007642)2.73783902
67Hypokalemia (HP:0002900)2.73729673
68Delayed CNS myelination (HP:0002188)2.71174500
69Myocardial infarction (HP:0001658)2.70792800
70Tubular atrophy (HP:0000092)2.70087233
71Bronchiectasis (HP:0002110)2.69672949
72Parakeratosis (HP:0001036)2.65191690
73Abnormality of purine metabolism (HP:0004352)2.62568368
74Hyperventilation (HP:0002883)2.62047023
75Abnormality of serum amino acid levels (HP:0003112)2.60297255
76Abnormal hair laboratory examination (HP:0003328)2.58731718
77Metabolic acidosis (HP:0001942)2.58000428
78Spontaneous abortion (HP:0005268)2.57760893
79Dicarboxylic aciduria (HP:0003215)2.57372518
80Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57372518
81Cardiovascular calcification (HP:0011915)2.57267196
82Molar tooth sign on MRI (HP:0002419)2.54772614
83Abnormality of midbrain morphology (HP:0002418)2.54772614
84Renal salt wasting (HP:0000127)2.48510793
85Abnormality of potassium homeostasis (HP:0011042)2.47335944
86Gout (HP:0001997)2.45436545
87Plantar hyperkeratosis (HP:0007556)2.39759971
88Hypotrichosis (HP:0001006)2.39690997
89Rickets (HP:0002748)2.38466018
90Lethargy (HP:0001254)2.38412849
91Abnormality of the renal medulla (HP:0100957)2.34865461
92Pancreatic fibrosis (HP:0100732)2.33947157
93Systemic lupus erythematosus (HP:0002725)2.32422414
94Hyperkalemia (HP:0002153)2.32110926
95Nephronophthisis (HP:0000090)2.32033147
96Hepatocellular carcinoma (HP:0001402)2.30555316
97Amyloidosis (HP:0011034)2.30126155
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22933719
99Pigmentary retinal degeneration (HP:0001146)2.20429625
100Erythroderma (HP:0001019)2.20077133
101Furrowed tongue (HP:0000221)2.19811142
102Ileus (HP:0002595)2.19571644
103Spastic diplegia (HP:0001264)2.18835062
104Acanthocytosis (HP:0001927)2.18557965
105Neonatal onset (HP:0003623)2.18245804
106Abnormality of proline metabolism (HP:0010907)2.17489270
107Hydroxyprolinuria (HP:0003080)2.17489270
108Alkalosis (HP:0001948)2.17249495
109Onycholysis (HP:0001806)2.17222104
110Stomach cancer (HP:0012126)2.16112276
111Skin nodule (HP:0200036)2.14061689
112Amelogenesis imperfecta (HP:0000705)2.14024814
113Irritability (HP:0000737)2.13956551
114Palmoplantar hyperkeratosis (HP:0000972)2.13220960
115Cerebral edema (HP:0002181)2.11061051
116Increased IgE level (HP:0003212)2.10766522
117Fragile nails (HP:0001808)2.10717199
118Dehydration (HP:0001944)2.10384420
119Conjunctival hamartoma (HP:0100780)2.10206648
120Hyponatremia (HP:0002902)2.09110741
121Confusion (HP:0001289)2.08236365
122Late onset (HP:0003584)2.07250750
123Congenital, generalized hypertrichosis (HP:0004540)2.06215456
124Woolly hair (HP:0002224)2.05384131
125Alopecia of scalp (HP:0002293)2.05179439
126Glomerulonephritis (HP:0000099)2.04422758
127Hypochromic microcytic anemia (HP:0004840)2.04106573
128Bronchitis (HP:0012387)2.04090213
129Esophageal varix (HP:0002040)2.02422692
130Pancreatitis (HP:0001733)2.02105579
131Cystic liver disease (HP:0006706)2.01522209
132Widely patent fontanelles and sutures (HP:0004492)2.01357017
133Abnormality of macular pigmentation (HP:0008002)2.00181358
134Cerebral palsy (HP:0100021)1.97597288
135Hypokalemic alkalosis (HP:0001949)1.97504241
136Abnormal hemoglobin (HP:0011902)1.96704393
137Abnormal gallbladder morphology (HP:0012437)1.96145951
138Abnormality of nail color (HP:0100643)1.94943822
139Glycosuria (HP:0003076)1.94592250
140Abnormality of urine glucose concentration (HP:0011016)1.94592250
141Hypophosphatemic rickets (HP:0004912)1.94309787
142Abnormality of magnesium homeostasis (HP:0004921)1.94153263
143Palmar hyperkeratosis (HP:0010765)1.94067424
144Brushfield spots (HP:0001088)1.93494533
145Abnormality of renal excretion (HP:0011036)1.92952156
146Abolished electroretinogram (ERG) (HP:0000550)1.92634645
147Abnormality of the axillary hair (HP:0100134)1.92448433
148Abnormality of secondary sexual hair (HP:0009888)1.92448433
149Hypoglycemic seizures (HP:0002173)1.92311039
150Gangrene (HP:0100758)1.92307598
151Generalized aminoaciduria (HP:0002909)1.91566557
152Abnormal cartilage morphology (HP:0002763)1.91220693
153Syncope (HP:0001279)1.90340893
154Vomiting (HP:0002013)1.90204275
155Cholelithiasis (HP:0001081)1.90169907
156Mitral stenosis (HP:0001718)1.87653292
157Abnormality of vitamin metabolism (HP:0100508)1.86449210
158Chronic sinusitis (HP:0011109)1.85322659
159Curly hair (HP:0002212)1.84195570
160Abnormal albumin level (HP:0012116)1.82072114
161Hypoalbuminemia (HP:0003073)1.82072114
162Abnormal rod and cone electroretinograms (HP:0008323)1.79602947
163Concave nail (HP:0001598)1.77506368
164Methylmalonic aciduria (HP:0012120)1.75000715
165Abnormality of sodium homeostasis (HP:0010931)1.73702784
166Pendular nystagmus (HP:0012043)1.73045287
167Proximal tubulopathy (HP:0000114)1.71358133
168Nasal polyposis (HP:0100582)1.69913277
169Abnormal biliary tract morphology (HP:0012440)1.69903525
170Abdominal distention (HP:0003270)1.69192592
171Villous atrophy (HP:0011473)1.69088040
172Abnormality of small intestinal villus morphology (HP:0011472)1.69088040
173Polydipsia (HP:0001959)1.68710159
174Abnormal drinking behavior (HP:0030082)1.68710159
175Hamartoma of the eye (HP:0010568)1.68526450
176Abnormality of the nasal mucosa (HP:0000433)1.67319965
177Attenuation of retinal blood vessels (HP:0007843)1.65948047
178Renal cortical cysts (HP:0000803)1.65699362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.03794742
2ACVR1B5.12059481
3BCKDK4.66256952
4ERN13.89585834
5FGFR43.85935555
6SIK12.87767088
7ADRBK22.78809034
8STK392.68382040
9MAP3K32.63644123
10PIK3CA2.52325753
11ERBB42.51007504
12LATS12.46679369
13MAPKAPK32.26909947
14EPHB22.17594904
15WNK42.09207797
16WNK32.08736722
17MAP4K22.07137324
18MET2.05911962
19BMPR1B1.98621324
20FRK1.97395629
21LMTK21.91864857
22PIK3CG1.91274553
23CASK1.89861085
24INSRR1.76024847
25TYK21.68676205
26FGFR21.65210354
27MAPK111.62349331
28TAOK31.58104135
29MST41.52734071
30PRKG21.52165322
31MAP3K21.51784454
32FER1.48008651
33STK38L1.43535610
34PTK61.42444982
35TLK11.39044519
36MAPK131.38914981
37MAP2K61.31593888
38MAPK151.30435612
39ZAK1.23959459
40TNIK1.23565118
41MAP2K41.21481866
42MAP3K141.18176498
43NME11.17809686
44DYRK1B1.17525570
45GRK11.14876792
46NEK91.13713647
47EPHA21.13653466
48MAP2K21.11613025
49ERBB21.08871724
50TXK1.08580403
51ABL21.05891845
52PRKCI1.01985562
53PRKAA21.00566905
54RIPK10.99086465
55PBK0.98881710
56MAP3K70.95013587
57STK240.94362451
58IRAK10.94284435
59LRRK20.93663522
60MATK0.93009702
61JAK20.90502750
62ADRBK10.89472463
63MAP3K110.84561352
64MAP3K100.84165809
65TRPM70.83888118
66CDK60.83351202
67TRIB30.81612830
68MUSK0.80217511
69PRKCE0.79990163
70STK100.79413191
71MAP2K10.79006928
72NLK0.77037557
73TGFBR10.74935064
74MAP3K10.74927791
75LATS20.73818236
76TRIM280.73277785
77TGFBR20.72768379
78MAPK40.69925505
79BCR0.68835224
80GSK3A0.67475247
81GRK60.67389586
82TBK10.67066585
83DAPK20.66231411
84PRKCZ0.65926271
85PTK20.65567295
86EPHA30.65121008
87CSNK1A10.64721390
88RPS6KB20.62617744
89PKN20.62155056
90EPHB10.58189493
91CDK30.57972274
92PRKACG0.57818415
93FGFR30.56239529
94JAK10.55857687
95MAP2K30.55620856
96STK30.55607325
97NUAK10.55569427
98CAMK2G0.53963658
99DYRK20.53411143
100CAMK2D0.53112133
101IKBKE0.51789302
102NME20.49305090
103IRAK30.48570607
104PTK2B0.48480048
105OXSR10.45880671
106CAMK2A0.43829631
107TIE10.43407599
108MYLK0.43340347
109TAOK10.41533140
110KDR0.40775792
111DYRK30.40492900
112PHKG20.40242692
113PHKG10.40242692
114PRKCQ0.40193228
115PDPK10.40127815
116PRKACA0.40022507
117MAP4K10.40016786
118MAPK120.39131807
119PINK10.38168607
120MAP3K120.37917660
121FLT30.37390771
122PRKCA0.37016570
123ERBB30.36668467
124MAP3K50.36105478
125MAP3K40.35871372
126HIPK20.35371046
127PRKAA10.34792513
128IGF1R0.34723887
129KIT0.33960206
130MAPK70.33701004
131PRKD10.32510293
132MAP3K60.31672272
133CSK0.30619268
134IKBKB0.30618284
135PRKCD0.29058806
136BLK0.28067871
137ABL10.27314049
138CHUK0.27024345
139GRK50.26202878
140PAK30.23895864
141ITK0.22527946
142BRSK20.22441495
143PDK20.21764995
144EPHA40.19327769
145MAPKAPK50.18665549
146AKT30.18662479
147PRKCG0.18605034
148SRC0.18366029
149MAPKAPK20.18350551
150MKNK20.17551227

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27101958
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33029844
3Nitrogen metabolism_Homo sapiens_hsa009103.24743943
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02049978
5Arginine biosynthesis_Homo sapiens_hsa002202.99588346
6Tryptophan metabolism_Homo sapiens_hsa003802.65858091
7Fatty acid degradation_Homo sapiens_hsa000712.52212139
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.50162826
9Complement and coagulation cascades_Homo sapiens_hsa046102.49429483
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46366600
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41227082
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.40923043
13Histidine metabolism_Homo sapiens_hsa003402.36427363
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29855909
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28726381
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.18812086
17Chemical carcinogenesis_Homo sapiens_hsa052042.16216174
18Butanoate metabolism_Homo sapiens_hsa006502.02724191
19Peroxisome_Homo sapiens_hsa041462.02007182
20Retinol metabolism_Homo sapiens_hsa008301.98195033
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.89802898
22PPAR signaling pathway_Homo sapiens_hsa033201.88470596
23beta-Alanine metabolism_Homo sapiens_hsa004101.79680750
24Fatty acid metabolism_Homo sapiens_hsa012121.77666683
25Fatty acid elongation_Homo sapiens_hsa000621.75842011
26Propanoate metabolism_Homo sapiens_hsa006401.75507034
27Phenylalanine metabolism_Homo sapiens_hsa003601.74596353
28Caffeine metabolism_Homo sapiens_hsa002321.71629583
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67126244
30Sulfur metabolism_Homo sapiens_hsa009201.64137280
31Staphylococcus aureus infection_Homo sapiens_hsa051501.60439009
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.56468605
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55795032
34Fat digestion and absorption_Homo sapiens_hsa049751.54257262
35Bile secretion_Homo sapiens_hsa049761.50385108
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49050473
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48262801
38Tyrosine metabolism_Homo sapiens_hsa003501.47860807
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.46904581
40Folate biosynthesis_Homo sapiens_hsa007901.41746930
41Selenocompound metabolism_Homo sapiens_hsa004501.40358944
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37801641
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36412779
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35127597
45ABC transporters_Homo sapiens_hsa020101.28705521
46Vitamin digestion and absorption_Homo sapiens_hsa049771.27738643
47Pancreatic secretion_Homo sapiens_hsa049721.26984831
48Asthma_Homo sapiens_hsa053101.25036805
49Steroid biosynthesis_Homo sapiens_hsa001001.24298651
50Starch and sucrose metabolism_Homo sapiens_hsa005001.19708219
51Pyruvate metabolism_Homo sapiens_hsa006201.19613921
52Phototransduction_Homo sapiens_hsa047441.16697293
53Maturity onset diabetes of the young_Homo sapiens_hsa049501.14752369
54Biosynthesis of amino acids_Homo sapiens_hsa012301.06456070
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.05498766
56Carbon metabolism_Homo sapiens_hsa012001.01107006
57Arginine and proline metabolism_Homo sapiens_hsa003300.98121926
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95511273
59* Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95425790
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94004420
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93542980
62Sulfur relay system_Homo sapiens_hsa041220.92981106
63Allograft rejection_Homo sapiens_hsa053300.89053105
64* Glutathione metabolism_Homo sapiens_hsa004800.87730288
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87622701
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85390790
67Type I diabetes mellitus_Homo sapiens_hsa049400.83720487
68Linoleic acid metabolism_Homo sapiens_hsa005910.80382888
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79842191
70Autoimmune thyroid disease_Homo sapiens_hsa053200.79568959
71Glycerolipid metabolism_Homo sapiens_hsa005610.78892578
72* Cyanoamino acid metabolism_Homo sapiens_hsa004600.76249649
73Lysine degradation_Homo sapiens_hsa003100.71786669
74Graft-versus-host disease_Homo sapiens_hsa053320.69964690
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67138127
76Vitamin B6 metabolism_Homo sapiens_hsa007500.65219910
77Fatty acid biosynthesis_Homo sapiens_hsa000610.63604251
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62553482
79Pentose phosphate pathway_Homo sapiens_hsa000300.59638516
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58124684
81Insulin secretion_Homo sapiens_hsa049110.53274431
82Taste transduction_Homo sapiens_hsa047420.50867027
83Renin secretion_Homo sapiens_hsa049240.49201468
84* Metabolic pathways_Homo sapiens_hsa011000.48971738
85Salivary secretion_Homo sapiens_hsa049700.46851773
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46567651
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44509767
88Serotonergic synapse_Homo sapiens_hsa047260.42418852
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41752759
90Arachidonic acid metabolism_Homo sapiens_hsa005900.41603519
91One carbon pool by folate_Homo sapiens_hsa006700.38165326
92Collecting duct acid secretion_Homo sapiens_hsa049660.37226255
93Tight junction_Homo sapiens_hsa045300.35902968
94Oxidative phosphorylation_Homo sapiens_hsa001900.33329619
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.32668034
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.32287973
97Fructose and mannose metabolism_Homo sapiens_hsa000510.23313888
98Nicotine addiction_Homo sapiens_hsa050330.23185159
99Mineral absorption_Homo sapiens_hsa049780.21728887
100Galactose metabolism_Homo sapiens_hsa000520.21407190
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.18921788
102Insulin resistance_Homo sapiens_hsa049310.16995207
103Antigen processing and presentation_Homo sapiens_hsa046120.16589141
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.16350773
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15396147
106Sphingolipid metabolism_Homo sapiens_hsa006000.15086749
107Regulation of autophagy_Homo sapiens_hsa041400.14628713
108Olfactory transduction_Homo sapiens_hsa047400.13629401
109Protein export_Homo sapiens_hsa030600.13564916
110Cocaine addiction_Homo sapiens_hsa050300.13488354
111Primary immunodeficiency_Homo sapiens_hsa053400.13305678
112Ether lipid metabolism_Homo sapiens_hsa005650.09690044
113Huntingtons disease_Homo sapiens_hsa050160.08027468
114Prion diseases_Homo sapiens_hsa050200.07990969
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07736439
116Gastric acid secretion_Homo sapiens_hsa049710.07082067
117Ribosome_Homo sapiens_hsa030100.04404114
118Renin-angiotensin system_Homo sapiens_hsa046140.03534513
119Protein digestion and absorption_Homo sapiens_hsa049740.01081180
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00891016
121Pertussis_Homo sapiens_hsa05133-0.2089999
122Basal cell carcinoma_Homo sapiens_hsa05217-0.2056668
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.1852670
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1670378
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1606901
126African trypanosomiasis_Homo sapiens_hsa05143-0.1455813
127Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1449548
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1090634
129Amoebiasis_Homo sapiens_hsa05146-0.0964174
130AMPK signaling pathway_Homo sapiens_hsa04152-0.0716336
131Glucagon signaling pathway_Homo sapiens_hsa04922-0.0470741
132Bladder cancer_Homo sapiens_hsa05219-0.0422999
133Hepatitis C_Homo sapiens_hsa05160-0.0229260
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0169390

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