GGN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.95507442
2spermatid development (GO:0007286)9.82233961
3epithelial cilium movement (GO:0003351)9.78191270
4motile cilium assembly (GO:0044458)9.47901234
5regulation of cilium movement (GO:0003352)9.30489355
6reproduction (GO:0000003)9.04474299
7piRNA metabolic process (GO:0034587)8.65274234
8cilium movement (GO:0003341)8.16350552
9male meiosis (GO:0007140)7.92969234
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.81370351
11synaptonemal complex organization (GO:0070193)7.71516152
12single fertilization (GO:0007338)7.39559502
13synaptonemal complex assembly (GO:0007130)7.38096281
14sperm capacitation (GO:0048240)7.35526810
15negative regulation of inclusion body assembly (GO:0090084)7.11115552
16* spermatogenesis (GO:0007283)6.46914661
17* male gamete generation (GO:0048232)6.44500354
18fertilization (GO:0009566)6.37896180
19organic cation transport (GO:0015695)6.17768631
20microtubule depolymerization (GO:0007019)6.00930067
21* gamete generation (GO:0007276)5.91894056
22male meiosis I (GO:0007141)5.77949187
23regulation of inclusion body assembly (GO:0090083)5.76547174
24germ cell development (GO:0007281)5.55896601
25regulation of microtubule-based movement (GO:0060632)5.50840549
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.46985196
27ventricular system development (GO:0021591)5.45259686
28DNA methylation involved in gamete generation (GO:0043046)5.30832669
29calcium ion-dependent exocytosis (GO:0017156)5.26037961
30rRNA methylation (GO:0031167)5.07641371
31chromosome organization involved in meiosis (GO:0070192)5.06365384
32seminiferous tubule development (GO:0072520)4.90329043
33left/right pattern formation (GO:0060972)4.89682723
34cell recognition (GO:0008037)4.83440893
35microtubule severing (GO:0051013)4.78398441
36response to acidic pH (GO:0010447)4.77367411
37phosphatidylethanolamine biosynthetic process (GO:0006646)4.74558495
38meiotic nuclear division (GO:0007126)4.74375572
39* multicellular organismal reproductive process (GO:0048609)4.66517189
40meiosis I (GO:0007127)4.64038673
41chromosome condensation (GO:0030261)4.57721580
42cranial nerve morphogenesis (GO:0021602)4.50746503
43adenosine receptor signaling pathway (GO:0001973)4.43326338
44DNA packaging (GO:0006323)4.39904985
45polyamine biosynthetic process (GO:0006596)4.38913296
46glycerol ether metabolic process (GO:0006662)4.30231478
47phosphatidylethanolamine metabolic process (GO:0046337)4.16827623
48meiotic cell cycle (GO:0051321)3.99281905
49rRNA modification (GO:0000154)3.98639109
50ether metabolic process (GO:0018904)3.96195590
51urogenital system development (GO:0001655)3.90919243
52protein polyglutamylation (GO:0018095)3.87916768
53spermatid nucleus differentiation (GO:0007289)3.87375756
54tooth mineralization (GO:0034505)3.84969714
55chaperone-mediated protein complex assembly (GO:0051131)3.81519422
56positive regulation of Rab GTPase activity (GO:0032851)3.77701774
57regulation of Rab GTPase activity (GO:0032313)3.77701774
58positive regulation of heat generation (GO:0031652)3.74233343
59* multicellular organismal development (GO:0007275)3.74163960
60genitalia morphogenesis (GO:0035112)3.72389907
61cell-cell junction maintenance (GO:0045217)3.65132025
62protein localization to cilium (GO:0061512)3.64765787
63cellular response to pH (GO:0071467)3.63083472
64monoubiquitinated protein deubiquitination (GO:0035520)3.62209294
65regulation of transcription involved in cell fate commitment (GO:0060850)3.61287841
66endocytic recycling (GO:0032456)3.49373363
67regulation of spindle checkpoint (GO:0090231)3.42975138
68membrane protein intracellular domain proteolysis (GO:0031293)3.42263246
69response to pheromone (GO:0019236)3.41857545
70regulation of vitamin D biosynthetic process (GO:0060556)3.41071082
71protein refolding (GO:0042026)3.35209544
72carnitine transport (GO:0015879)3.32621765
73amino-acid betaine transport (GO:0015838)3.32621765
74gene silencing by RNA (GO:0031047)3.29827413
75mitotic sister chromatid cohesion (GO:0007064)3.23585419
76carnitine transmembrane transport (GO:1902603)3.22120603
77chromatin silencing (GO:0006342)3.18638862
78negative regulation of organelle assembly (GO:1902116)3.16664959
79regulation of ARF GTPase activity (GO:0032312)3.12375058
80meiotic cell cycle process (GO:1903046)3.11502599
81regulation of T-helper 2 cell differentiation (GO:0045628)3.09691508
82cellular ketone body metabolic process (GO:0046950)3.09585293
83glycolytic process (GO:0006096)3.05214982
84nucleus organization (GO:0006997)3.04748857
85synapsis (GO:0007129)3.01183380
86sexual reproduction (GO:0019953)3.00290586
87hyaluronan catabolic process (GO:0030214)2.98401968
88microtubule-based movement (GO:0007018)2.98223313
89cellular response to ATP (GO:0071318)2.97566115
90intraciliary transport (GO:0042073)2.97539875
91cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.97065346
92single strand break repair (GO:0000012)2.95316324
93interferon-gamma secretion (GO:0072643)2.94920359
94microtubule polymerization or depolymerization (GO:0031109)2.94167386
95nucleosome disassembly (GO:0006337)2.92175028
96protein-DNA complex disassembly (GO:0032986)2.92175028
97axoneme assembly (GO:0035082)2.91659498
98RNA localization (GO:0006403)2.88064270
99nuclear pore complex assembly (GO:0051292)2.86381308
100cilium organization (GO:0044782)2.85375553
101protein targeting to Golgi (GO:0000042)2.84312738
102negative regulation of skeletal muscle tissue development (GO:0048642)2.82167462
103RNA destabilization (GO:0050779)2.81039363
104negative regulation of catenin import into nucleus (GO:0035414)2.79994821
105response to ATP (GO:0033198)2.77583779
106positive regulation of histone deacetylation (GO:0031065)2.75661599
107peptidyl-glutamic acid modification (GO:0018200)2.75387003
108receptor recycling (GO:0001881)2.75001907
109polyol catabolic process (GO:0046174)2.74671087
110positive regulation of chemokine biosynthetic process (GO:0045080)2.74420045
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73408309
112cilium morphogenesis (GO:0060271)2.72324806
113gene silencing (GO:0016458)2.71303551
114sequestering of actin monomers (GO:0042989)2.70772012
115serine transport (GO:0032329)2.70108564
116cilium assembly (GO:0042384)2.70038570
117regulation of apoptotic process involved in morphogenesis (GO:1902337)2.69688995
118mitochondrial fission (GO:0000266)2.69405425
119adhesion of symbiont to host cell (GO:0044650)2.68892965
120virion attachment to host cell (GO:0019062)2.68892965
121homeostasis of number of cells within a tissue (GO:0048873)2.68885447
122lactate metabolic process (GO:0006089)2.68435210
123nucleoside diphosphate phosphorylation (GO:0006165)2.67989160
124positive regulation of protein kinase C signaling (GO:0090037)2.65709742
125cerebral cortex neuron differentiation (GO:0021895)2.64602929
126alditol metabolic process (GO:0019400)2.64550581
127regulation of cilium assembly (GO:1902017)2.64532169
128negative regulation of Rho protein signal transduction (GO:0035024)2.64199297
129cellular component assembly involved in morphogenesis (GO:0010927)2.63601726
130histone H3-K9 demethylation (GO:0033169)2.63322639
131L-alpha-amino acid transmembrane transport (GO:1902475)2.61561935
132cochlea morphogenesis (GO:0090103)2.60757629
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59663536
134establishment of protein localization to Golgi (GO:0072600)2.59176599
135regulation of chromatin binding (GO:0035561)2.59019998
136ketone body metabolic process (GO:1902224)2.58939337
137protein K11-linked deubiquitination (GO:0035871)2.58400165
138semaphorin-plexin signaling pathway (GO:0071526)2.56567960
139substrate-dependent cell migration (GO:0006929)2.56521567
140regulation of centriole replication (GO:0046599)2.55020999
141regulation of protein kinase A signaling (GO:0010738)2.54867830
142dendritic spine organization (GO:0097061)2.54617950
143response to pH (GO:0009268)2.54557555
144regulation of meiosis I (GO:0060631)2.52549149
145intracellular estrogen receptor signaling pathway (GO:0030520)2.52023170
146urinary tract smooth muscle contraction (GO:0014848)2.50495839
147cell junction maintenance (GO:0034331)2.50072318
148regulation of vitamin metabolic process (GO:0030656)2.48935257
149peptidyl-proline hydroxylation (GO:0019511)2.46408337
150stress fiber assembly (GO:0043149)2.46265010
151regulation of response to osmotic stress (GO:0047484)2.44526995
152sperm motility (GO:0030317)13.6475825
153fusion of sperm to egg plasma membrane (GO:0007342)13.1134355
154acrosome reaction (GO:0007340)12.0929132
155sperm-egg recognition (GO:0035036)11.3457849
156cilium or flagellum-dependent cell motility (GO:0001539)11.3220069
157multicellular organism reproduction (GO:0032504)10.7709821
158acrosome assembly (GO:0001675)10.6977365
159axonemal dynein complex assembly (GO:0070286)10.3597856
160cell wall macromolecule metabolic process (GO:0044036)10.3202356
161cell wall macromolecule catabolic process (GO:0016998)10.3202356
162binding of sperm to zona pellucida (GO:0007339)10.2898035
163cell-cell recognition (GO:0009988)10.1725811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.34343841
2EZH2_22144423_ChIP-Seq_EOC_Human4.53855439
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.02299750
4LXR_22292898_ChIP-Seq_THP-1_Human3.52365262
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.03409114
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03304331
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88434428
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83343849
9P68_20966046_ChIP-Seq_HELA_Human2.66378230
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63902160
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.61662032
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.47684105
13* CTCF_27219007_Chip-Seq_Bcells_Human2.41238266
14GATA1_26923725_Chip-Seq_HPCs_Mouse2.25042128
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23884434
16VDR_21846776_ChIP-Seq_THP-1_Human2.19864898
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.17902198
18VDR_22108803_ChIP-Seq_LS180_Human2.17248573
19SMC4_20622854_ChIP-Seq_HELA_Human2.13581811
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.06473420
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.4633468
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.98977101
23RACK7_27058665_Chip-Seq_MCF-7_Human1.95592209
24ZNF274_21170338_ChIP-Seq_K562_Hela1.93804957
25SA1_27219007_Chip-Seq_ERYTHROID_Human1.90558574
26ELK4_26923725_Chip-Seq_MESODERM_Mouse1.89129936
27KDM2B_26808549_Chip-Seq_DND41_Human1.87088457
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83636771
29* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83127661
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.81223878
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80989071
32KDM2B_26808549_Chip-Seq_K562_Human1.79518492
33* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78742379
34TP53_22127205_ChIP-Seq_IMR90_Human1.75804985
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75494214
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.74314134
37UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.74256740
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72713831
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.69066747
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66809071
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65961278
42SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.63702246
43SA1_27219007_Chip-Seq_Bcells_Human1.63625428
44DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62941080
45STAT1_17558387_ChIP-Seq_HELA_Human1.61912036
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61786908
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61673078
48MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.61180204
49TP63_22573176_ChIP-Seq_HFKS_Human1.59265159
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57650057
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.55397075
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.53385911
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.53216725
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.51916271
55GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50600300
56SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50278821
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.49898711
58FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48583459
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48198975
60KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48140946
61MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.47149412
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45630040
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.44286397
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42764573
65TCF7_22412390_ChIP-Seq_EML_Mouse1.42141755
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.41438933
67CBP_20019798_ChIP-Seq_JUKART_Human1.40698622
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40698622
69CTCF_21964334_Chip-Seq_Bcells_Human1.39591996
70MAF_26560356_Chip-Seq_TH2_Human1.39559653
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37646135
72* FOXP1_21924763_ChIP-Seq_HESCs_Human1.34196146
73RARB_24833708_ChIP-Seq_LIVER_Mouse1.33530191
74* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33259197
75CREB1_26743006_Chip-Seq_LNCaP_Human1.32525206
76ERA_21632823_ChIP-Seq_H3396_Human1.32481021
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.32087032
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31994338
79LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31717036
80VDR_24763502_ChIP-Seq_THP-1_Human1.30206236
81P53_21459846_ChIP-Seq_SAOS-2_Human1.29712437
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29554423
83RAC3_21632823_ChIP-Seq_H3396_Human1.27667696
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26376821
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.25379809
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24886488
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24629065
88UBF1/2_26484160_Chip-Seq_HMECs_Human1.23417101
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22599384
90P300_27268052_Chip-Seq_Bcells_Human1.22073894
91KDM2B_26808549_Chip-Seq_REH_Human1.21815358
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.20493614
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.20397171
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.19637455
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19303684
96RUNX1_26923725_Chip-Seq_HPCs_Mouse1.18568191
97ATF3_27146783_Chip-Seq_COLON_Human1.17757853
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17741265
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17521408
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17229791
101* EZH2_27294783_Chip-Seq_ESCs_Mouse1.16681804
102GF1_26923725_Chip-Seq_HPCs_Mouse1.16329315
103ELF1_20517297_ChIP-Seq_JURKAT_Human1.16058515
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15886806
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15864279
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15668071
107ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14237176
108GATA3_21867929_ChIP-Seq_TH1_Mouse1.14080565
109P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13482317
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12692512
111DROSHA_22980978_ChIP-Seq_HELA_Human1.12331415
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12258685
113KAP1_22055183_ChIP-Seq_ESCs_Mouse1.11658095
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.11597457
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.11526920
116SPI1_26923725_Chip-Seq_HPCs_Mouse1.11360283
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11136389
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11136389
119REST_21632747_ChIP-Seq_MESCs_Mouse1.11125766
120TAF2_19829295_ChIP-Seq_ESCs_Human1.11050651
121CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10852953
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10688350
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.10342557
124OCT4_19829295_ChIP-Seq_ESCs_Human1.10053657
125RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09825422
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09727644
127MYC_27129775_Chip-Seq_CORNEA_Mouse1.07829909
128SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07715450
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07658352
130P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07047202
131ERG_20517297_ChIP-Seq_VCAP_Human1.05675578
132TP53_20018659_ChIP-ChIP_R1E_Mouse1.05550668
133E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.04500793
134NFE2_27457419_Chip-Seq_LIVER_Mouse1.04322229
135KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04131100
136CTCF_20526341_ChIP-Seq_ESCs_Human1.03925576
137NCOR1_26117541_ChIP-Seq_K562_Human1.03389541
138TET1_21451524_ChIP-Seq_MESCs_Mouse1.02883208
139RARA_24833708_ChIP-Seq_LIVER_Mouse1.02233181
140SMC3_22415368_ChIP-Seq_MEFs_Mouse1.02196709
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00823382
142GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99891819
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99817279
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99536777
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99426493
146* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99018718
147* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98951731
148NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98827133
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98531251
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97742618
151ESET_19884257_ChIP-Seq_ESCs_Mouse0.96863657
152TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96564977
153SOX11_22085726_ChIP-Seq_ESNs_Mouse0.95893892
154ESR2_21235772_ChIP-Seq_MCF-7_Human0.95200380
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95033948
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94854156
157SOX2_21211035_ChIP-Seq_LN229_Human0.94127363
158PHF8_20622854_ChIP-Seq_HELA_Human0.93497496
159BCOR_27268052_Chip-Seq_Bcells_Human0.93203112
160JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.92505275
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92084411
162TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90687141
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90441120
164FLI1_21867929_ChIP-Seq_CD8_Mouse0.90166145
165NANOG_20526341_ChIP-Seq_ESCs_Human0.88004138
166RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.86433256
167CRX_20693478_ChIP-Seq_RETINA_Mouse0.86044415
168LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85943747
169SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85396237
170CBX2_27304074_Chip-Seq_ESCs_Mouse0.84924204
171BCL6_27268052_Chip-Seq_Bcells_Human0.84391653
172RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83819564
173CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.83129057
174E2F1_20622854_ChIP-Seq_HELA_Human0.82925290
175NFYB_21822215_ChIP-Seq_K562_Human0.82893397
176CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.82657129
177STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81765946
178STAT1_20625510_ChIP-Seq_HELA_Human0.81717798
179RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81680081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.99315985
2MP0001929_abnormal_gametogenesis5.43269247
3MP0008877_abnormal_DNA_methylation4.38595615
4MP0005451_abnormal_body_composition4.01502143
5MP0002210_abnormal_sex_determination3.48234694
6MP0005423_abnormal_somatic_nervous3.35041665
7MP0003303_peritoneal_inflammation3.28144063
8MP0002161_abnormal_fertility/fecundity3.27541283
9MP0004510_myositis3.23225761
10MP0005058_abnormal_lysosome_morphology3.04653944
11MP0001145_abnormal_male_reproductive2.93649973
12MP0003705_abnormal_hypodermis_morpholog2.88835083
13MP0002653_abnormal_ependyma_morphology2.73504697
14MP0005670_abnormal_white_adipose2.67859442
15MP0000653_abnormal_sex_gland2.51311592
16MP0000678_abnormal_parathyroid_gland2.47902658
17MP0005083_abnormal_biliary_tract2.47722651
18MP0009840_abnormal_foam_cell2.22263965
19MP0005410_abnormal_fertilization16.1113653
20MP0005623_abnormal_meninges_morphology1.94101845
21MP0002254_reproductive_system_inflammat1.82328638
22MP0003091_abnormal_cell_migration1.77515664
23MP0003172_abnormal_lysosome_physiology1.67291903
24MP0003453_abnormal_keratinocyte_physiol1.65237283
25MP0002160_abnormal_reproductive_system1.59223514
26MP0000750_abnormal_muscle_regeneration1.58638945
27MP0003646_muscle_fatigue1.53127212
28MP0004859_abnormal_synaptic_plasticity1.52176951
29MP0002282_abnormal_trachea_morphology1.46804427
30MP0005409_darkened_coat_color1.46497593
31MP0005171_absent_coat_pigmentation1.42843348
32MP0000569_abnormal_digit_pigmentation1.37079588
33MP0002735_abnormal_chemical_nociception1.35417517
34MP0004233_abnormal_muscle_weight1.25891289
35MP0009764_decreased_sensitivity_to1.23353539
36MP0000003_abnormal_adipose_tissue1.19459505
37MP0003448_altered_tumor_morphology1.16543819
38MP0000733_abnormal_muscle_development1.14632213
39MP0005595_abnormal_vascular_smooth1.13760300
40MP0005248_abnormal_Harderian_gland1.13247058
41MP0009278_abnormal_bone_marrow1.12059941
42MP0006082_CNS_inflammation1.12042799
43MP0003136_yellow_coat_color1.12016063
44MP0009053_abnormal_anal_canal1.08812154
45MP0002249_abnormal_larynx_morphology1.07509514
46MP0000343_altered_response_to1.07271209
47MP0001542_abnormal_bone_strength1.05889158
48MP0000538_abnormal_urinary_bladder1.05595335
49MP0005167_abnormal_blood-brain_barrier1.05373300
50MP0001958_emphysema1.04513568
51MP0005310_abnormal_salivary_gland1.02939287
52MP0004858_abnormal_nervous_system1.02875735
53MP0002332_abnormal_exercise_endurance1.02651300
54MP0001765_abnormal_ion_homeostasis1.02285841
55MP0001270_distended_abdomen0.98839639
56MP0010030_abnormal_orbit_morphology0.98804049
57MP0001188_hyperpigmentation0.98297638
58MP0001968_abnormal_touch/_nociception0.97252440
59MP0002998_abnormal_bone_remodeling0.96817209
60MP0004947_skin_inflammation0.96643938
61MP0005076_abnormal_cell_differentiation0.93794538
62MP0010386_abnormal_urinary_bladder0.93008249
63MP0008058_abnormal_DNA_repair0.91652208
64MP0001545_abnormal_hematopoietic_system0.91614667
65MP0005397_hematopoietic_system_phenotyp0.91614667
66MP0002822_catalepsy0.90316456
67MP0003115_abnormal_respiratory_system0.88732567
68MP0005377_hearing/vestibular/ear_phenot0.85287669
69MP0003878_abnormal_ear_physiology0.85287669
70MP0005647_abnormal_sex_gland0.84017994
71MP0008995_early_reproductive_senescence0.83358151
72MP0010368_abnormal_lymphatic_system0.80223843
73MP0003075_altered_response_to0.79459779
74MP0003436_decreased_susceptibility_to0.77772049
75MP0001984_abnormal_olfaction0.77150724
76MP0003300_gastrointestinal_ulcer0.76171877
77MP0005023_abnormal_wound_healing0.75091981
78MP0005389_reproductive_system_phenotype0.74489269
79MP0010094_abnormal_chromosome_stability0.74361137
80MP0001533_abnormal_skeleton_physiology0.72512557
81MP0002089_abnormal_postnatal_growth/wei0.71186877
82MP0002896_abnormal_bone_mineralization0.71080331
83MP0003137_abnormal_impulse_conducting0.70899254
84MP0009046_muscle_twitch0.70255898
85MP0000955_abnormal_spinal_cord0.70113925
86MP0008874_decreased_physiological_sensi0.69778864
87MP0008438_abnormal_cutaneous_collagen0.67380731
88MP0005666_abnormal_adipose_tissue0.67170153
89MP0002148_abnormal_hypersensitivity_rea0.64651074
90MP0000358_abnormal_cell_content/0.64462948
91MP0002928_abnormal_bile_duct0.63439840
92MP0009384_cardiac_valve_regurgitation0.62193753
93MP0002877_abnormal_melanocyte_morpholog0.59885378
94MP0004808_abnormal_hematopoietic_stem0.58917538
95MP0000026_abnormal_inner_ear0.58500279
96MP0001970_abnormal_pain_threshold0.58293510
97MP0005166_decreased_susceptibility_to0.58059423
98MP0001243_abnormal_dermal_layer0.58002586
99MP0003111_abnormal_nucleus_morphology0.55731266
100MP0005084_abnormal_gallbladder_morpholo0.55541157
101MP0003718_maternal_effect0.55490744
102MP0001879_abnormal_lymphatic_vessel0.55166199
103MP0008004_abnormal_stomach_pH0.54830446
104MP0000747_muscle_weakness0.54765877
105MP0001663_abnormal_digestive_system0.52413590
106MP0008961_abnormal_basal_metabolism0.52398302
107MP0001756_abnormal_urination0.52348615
108MP0002234_abnormal_pharynx_morphology0.52053464
109MP0001324_abnormal_eye_pigmentation0.51455142
110MP0001293_anophthalmia0.50653297
111MP0003699_abnormal_female_reproductive0.47848620
112MP0008007_abnormal_cellular_replicative0.46858457
113MP0000534_abnormal_ureter_morphology0.46011564
114MP0003011_delayed_dark_adaptation0.45658903
115MP0003045_fibrosis0.45044252
116MP0010307_abnormal_tumor_latency0.44193767
117MP0009115_abnormal_fat_cell0.43331985
118MP0008057_abnormal_DNA_replication0.42886135
119MP0005636_abnormal_mineral_homeostasis0.42511128
120MP0002269_muscular_atrophy0.41726988
121MP0003329_amyloid_beta_deposits0.41459790
122MP0003786_premature_aging0.39005182
123MP0001730_embryonic_growth_arrest0.38031351
124MP0002405_respiratory_system_inflammati0.36769102
125MP0003950_abnormal_plasma_membrane0.34920219
126MP0003942_abnormal_urinary_system0.34870057
127MP0003879_abnormal_hair_cell0.33582632
128MP0001348_abnormal_lacrimal_gland0.33297434
129MP0004036_abnormal_muscle_relaxation0.33295515
130MP0005174_abnormal_tail_pigmentation0.33292054
131MP0001764_abnormal_homeostasis0.32380227
132MP0000313_abnormal_cell_death0.29882065
133MP0005375_adipose_tissue_phenotype0.29603723
134MP0002971_abnormal_brown_adipose0.29358912
135MP0000604_amyloidosis0.29066101
136MP0002295_abnormal_pulmonary_circulatio0.28676110
137MP0005391_vision/eye_phenotype0.26875170
138MP0001119_abnormal_female_reproductive0.25599022
139MP0002092_abnormal_eye_morphology0.25302904
140MP0001986_abnormal_taste_sensitivity0.24300665
141MP0001727_abnormal_embryo_implantation0.23399954
142MP0001849_ear_inflammation0.23371136
143MP0000751_myopathy0.23339384
144MP0003077_abnormal_cell_cycle0.22772900
145MP0003948_abnormal_gas_homeostasis0.22290519
146MP0003861_abnormal_nervous_system0.22262557
147MP0002084_abnormal_developmental_patter0.21379806
148MP0004133_heterotaxia0.20537102
149MP0001851_eye_inflammation0.20489494
150MP0005253_abnormal_eye_physiology0.20408472
151MP0004811_abnormal_neuron_physiology0.20366784
152MP0005380_embryogenesis_phenotype0.19775543
153MP0001672_abnormal_embryogenesis/_devel0.19775543
154MP0005257_abnormal_intraocular_pressure0.19669947
155MP0001661_extended_life_span0.19290375
156MP0003279_aneurysm0.18544640
157MP0004742_abnormal_vestibular_system0.18072085
158MP0003633_abnormal_nervous_system0.17737075
159MP0002169_no_abnormal_phenotype0.17241011
160MP0002873_normal_phenotype0.16989974
161MP0001697_abnormal_embryo_size0.16628998
162MP0000015_abnormal_ear_pigmentation0.16457858
163MP0003943_abnormal_hepatobiliary_system0.16389467
164MP0002152_abnormal_brain_morphology0.16118946
165MP0002080_prenatal_lethality0.15388359
166MP0004130_abnormal_muscle_cell0.15074370
167MP0003984_embryonic_growth_retardation0.15068013
168MP0008770_decreased_survivor_rate0.15021841
169MP0002736_abnormal_nociception_after0.14969653
170MP0000685_abnormal_immune_system0.14962715
171MP0003787_abnormal_imprinting0.14806760

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.91910265
2Abnormal respiratory motile cilium morphology (HP:0005938)8.88919590
3Abnormal respiratory epithelium morphology (HP:0012253)8.88919590
4Rhinitis (HP:0012384)7.54302521
5Infertility (HP:0000789)6.99542051
6Abnormal ciliary motility (HP:0012262)6.89978977
7Chronic bronchitis (HP:0004469)6.88645522
8Nasal polyposis (HP:0100582)6.67683586
9Abnormality of the nasal mucosa (HP:0000433)5.57444300
10Male infertility (HP:0003251)4.93920938
11Bronchitis (HP:0012387)4.77784840
12Bronchiectasis (HP:0002110)4.57976717
13Nephronophthisis (HP:0000090)4.54272688
14Thin bony cortex (HP:0002753)4.00257724
15Severe visual impairment (HP:0001141)3.89416400
16Chronic hepatic failure (HP:0100626)3.80314029
17Abnormal spermatogenesis (HP:0008669)3.74883731
18Turricephaly (HP:0000262)3.72500981
19Recurrent otitis media (HP:0000403)3.45664959
20Abnormality of the renal medulla (HP:0100957)3.39975979
21Recurrent bronchitis (HP:0002837)3.37211051
22Testicular atrophy (HP:0000029)3.29708133
23Distal upper limb amyotrophy (HP:0007149)3.23663110
24Upper limb amyotrophy (HP:0009129)3.23663110
25Attenuation of retinal blood vessels (HP:0007843)3.21338059
26Bony spicule pigmentary retinopathy (HP:0007737)3.21066773
27Recurrent sinusitis (HP:0011108)3.14561487
28Abnormality of the aortic arch (HP:0012303)3.12713797
29Hand muscle atrophy (HP:0009130)3.10070416
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.09668962
31Ulnar bowing (HP:0003031)3.05816716
32Impulsivity (HP:0100710)3.05180311
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.95963505
34Abnormality of glycolipid metabolism (HP:0010969)2.95963505
35Abnormality of liposaccharide metabolism (HP:0010968)2.95963505
36Hypoalphalipoproteinemia (HP:0003233)2.90220869
37Abnormality of the costochondral junction (HP:0000919)2.88431852
38Tubulointerstitial nephritis (HP:0001970)2.83164536
39Resting tremor (HP:0002322)2.78705005
40Tubular atrophy (HP:0000092)2.78136104
41Gonadotropin excess (HP:0000837)2.72966989
42Nuclear cataract (HP:0100018)2.69181052
43Flat capital femoral epiphysis (HP:0003370)2.67893495
44Intestinal fistula (HP:0100819)2.63541491
45Rectal fistula (HP:0100590)2.59190678
46Rectovaginal fistula (HP:0000143)2.59190678
47Prolonged neonatal jaundice (HP:0006579)2.58290230
48Atelectasis (HP:0100750)2.57425082
49Molar tooth sign on MRI (HP:0002419)2.57369631
50Abnormality of midbrain morphology (HP:0002418)2.57369631
51Renovascular hypertension (HP:0100817)2.56108385
52Enlarged epiphyses (HP:0010580)2.55987001
53Zonular cataract (HP:0010920)2.53770502
54Tubulointerstitial abnormality (HP:0001969)2.51291321
55Delayed epiphyseal ossification (HP:0002663)2.50327468
56Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45030447
57Broad face (HP:0000283)2.43464956
58Long toe (HP:0010511)2.42349121
59Vaginal fistula (HP:0004320)2.38556853
60Abnormal gallbladder physiology (HP:0012438)2.37464872
61Cholecystitis (HP:0001082)2.37464872
62Progressive sensorineural hearing impairment (HP:0000408)2.37243563
63Cervical subluxation (HP:0003308)2.36977262
64Azoospermia (HP:0000027)2.36127462
65Abnormality of the hepatic vasculature (HP:0006707)2.35451379
66Renal Fanconi syndrome (HP:0001994)2.34030817
67Flattened epiphyses (HP:0003071)2.33579258
68Genu recurvatum (HP:0002816)2.23578295
69Buphthalmos (HP:0000557)2.23099037
70Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.20421108
71Spastic tetraparesis (HP:0001285)2.18398001
72Heterotopia (HP:0002282)2.18168692
73Broad metatarsal (HP:0001783)2.17796364
74Widely patent fontanelles and sutures (HP:0004492)2.17159204
75Joint stiffness (HP:0001387)2.16393730
76Poikiloderma (HP:0001029)2.15403324
77Atrophic scars (HP:0001075)2.13383367
78Hyperacusis (HP:0010780)2.09664284
79Tubulointerstitial fibrosis (HP:0005576)2.09223661
80Abnormality of polysaccharide metabolism (HP:0011012)2.08635168
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08635168
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08635168
83Protuberant abdomen (HP:0001538)2.05698601
84Abnormality of the lower motor neuron (HP:0002366)2.03803374
85Bradycardia (HP:0001662)2.03311345
86Dysostosis multiplex (HP:0000943)2.01551999
87Bowed forearm bones (HP:0003956)2.01356209
88Bowing of the arm (HP:0006488)2.01356209
89Amblyopia (HP:0000646)2.01329378
90Choroideremia (HP:0001139)2.00581298
91Dynein arm defect of respiratory motile cilia (HP:0012255)13.0087192
92Absent/shortened dynein arms (HP:0200106)13.0087192
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9036975
94Dyschromatopsia (HP:0007641)1.97945518
95Urinary glycosaminoglycan excretion (HP:0003541)1.97155915
96Mucopolysacchariduria (HP:0008155)1.97155915
97Medial flaring of the eyebrow (HP:0010747)1.97092057
98Postaxial foot polydactyly (HP:0001830)1.96801179
99Premature rupture of membranes (HP:0001788)1.95811909
100Spinal rigidity (HP:0003306)1.94721429
101Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93682961
102Mesangial abnormality (HP:0001966)1.92268128
103Stage 5 chronic kidney disease (HP:0003774)1.91013181
104Protrusio acetabuli (HP:0003179)1.90704694
105Congenital glaucoma (HP:0001087)1.90663053
106Axonal loss (HP:0003447)1.89936212
107Facial hemangioma (HP:0000329)1.89399770
108Bell-shaped thorax (HP:0001591)1.89197876
109Increased cerebral lipofuscin (HP:0011813)1.88824161
110Polydipsia (HP:0001959)1.87578593
111Abnormal drinking behavior (HP:0030082)1.87578593
112Short ribs (HP:0000773)1.86240341
113Absent frontal sinuses (HP:0002688)1.85920807
114Annular pancreas (HP:0001734)1.83297641
115Portal hypertension (HP:0001409)1.83148830
116Congenital hepatic fibrosis (HP:0002612)1.82828380
117Ankle contracture (HP:0006466)1.81684313
118Hyperparathyroidism (HP:0000843)1.78058945
119Hypertensive crisis (HP:0100735)1.77857842
120Cerebral aneurysm (HP:0004944)1.76119638
121Achilles tendon contracture (HP:0001771)1.75741831
122Fibular hypoplasia (HP:0003038)1.73032787
123Deformed sella turcica (HP:0002681)1.72012987
124Cone-rod dystrophy (HP:0000548)1.71157021
125Abnormal biliary tract physiology (HP:0012439)1.70728806
126Bile duct proliferation (HP:0001408)1.70728806
127Hemorrhage of the eye (HP:0011885)1.70678715
128Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.70653968
129Facial shape deformation (HP:0011334)1.69928196
130Potter facies (HP:0002009)1.69928196
131Anteriorly placed anus (HP:0001545)1.69910341
132Amyotrophic lateral sclerosis (HP:0007354)1.68490251
133Oculomotor apraxia (HP:0000657)1.68101443
134Hypophosphatemia (HP:0002148)1.68014373
135Abnormality of the renal cortex (HP:0011035)1.66539740
136Abnormality of dentin (HP:0010299)1.65986058
137J-shaped sella turcica (HP:0002680)1.65862111
138Abnormal large intestine physiology (HP:0012700)1.65687720
139Bowel incontinence (HP:0002607)1.63922446
140Retinal dysplasia (HP:0007973)1.63648280
141Decreased central vision (HP:0007663)1.62974092
142Abnormality of the vertebral endplates (HP:0005106)1.62559344
143Occipital encephalocele (HP:0002085)1.62258945
144Renal dysplasia (HP:0000110)1.57587897
145Abnormality of renal excretion (HP:0011036)1.55531726
146Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53617872
147Microglossia (HP:0000171)1.53598286
148Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.49432970
149Absent epiphyses (HP:0010577)1.49432970
150Impaired proprioception (HP:0010831)1.48295772
151Short thorax (HP:0010306)1.46683360
152Hemiparesis (HP:0001269)1.45641158
153Cystic liver disease (HP:0006706)1.44837118
154Loss of speech (HP:0002371)1.44483143
155Neurofibrillary tangles (HP:0002185)1.44097245
156Broad distal phalanx of finger (HP:0009836)1.42848995
157Abnormality of the dental root (HP:0006486)1.42290830
158Taurodontia (HP:0000679)1.42290830
159Abnormality of permanent molar morphology (HP:0011071)1.42290830
160Facial cleft (HP:0002006)1.40782160
161Asymmetric septal hypertrophy (HP:0001670)1.37438031
162Postaxial hand polydactyly (HP:0001162)1.37397778
163Nephropathy (HP:0000112)1.36277667
164Abnormality of the sella turcica (HP:0002679)1.34133468
165Abnormal urine output (HP:0012590)1.33275215
166Chronic sinusitis (HP:0011109)1.32887804
167Decreased electroretinogram (ERG) amplitude (HP:0000654)1.32084589
168Abnormality of molar (HP:0011077)1.31454302
169Abnormality of molar morphology (HP:0011070)1.31454302
170Difficulty climbing stairs (HP:0003551)1.29964479
171Truncal obesity (HP:0001956)1.29471616
172Abnormality of the dental pulp (HP:0006479)1.29152288
173Easy fatigability (HP:0003388)1.28401248
174Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.27601566
175Short femoral neck (HP:0100864)1.26181456
176Short nail (HP:0001799)1.25795294
177Glucose intolerance (HP:0000833)1.23275567
178Aplasia/Hypoplasia of the tongue (HP:0010295)1.21454510
179Cerebral inclusion bodies (HP:0100314)1.21206796
180Pachygyria (HP:0001302)1.20690617
181Cerebellar dysplasia (HP:0007033)1.20574746
182Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.17854601
183Aplasia/Hypoplasia of the lens (HP:0008063)1.17114062
184Bundle branch block (HP:0011710)1.17086509
185EMG: neuropathic changes (HP:0003445)1.16383231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.56706654
2PDK47.56706654
3TESK16.73437012
4PRKD35.84177244
5ICK4.84583935
6PDK24.82486126
7DDR24.11067098
8IRAK33.22547263
9MAP3K112.90623413
10PTK2B2.49471236
11EPHB22.48731213
12NME22.37606554
13PNCK2.33167534
14WNK42.22563948
15STK392.00061399
16NEK21.82112857
17STK381.74261268
18TAOK21.67809871
19SIK21.65824135
20LATS21.65358854
21DYRK1B1.63250978
22SIK11.54734694
23PIM21.49552388
24BLK1.41959675
25RPS6KA21.40365480
26BRD41.39509907
27MST1R1.26308753
28CDC42BPA1.24949194
29MOS1.23476832
30EPHA21.22407637
31GRK71.20291663
32SMG11.15029436
33TYRO31.11062332
34MAPK151.07419437
35WNK11.04795863
36BRAF1.03748733
37PDK11.02437317
38ABL20.91372069
39CAMK1D0.90018525
40BMX0.89395075
41MAP3K10.87861691
42PDGFRA0.86760584
43RPS6KL10.86619453
44RPS6KC10.86619453
45DYRK30.85818076
46EEF2K0.85691192
47CAMK1G0.84406843
48ARAF0.84202527
49TESK20.82125083
50PASK0.80018731
51TGFBR20.79070570
52PTK20.77264976
53CHUK0.76531440
54STK30.76486225
55RPS6KA60.76123569
56MAP4K20.74850784
57MAP3K30.70182972
58NTRK10.64693383
59PRKD20.63146748
60CDK140.63009919
61MAP3K80.61657137
62ACVR1B0.61377971
63CCNB10.61178335
64TTK0.60775648
65RIPK40.60546073
66PDPK10.59221470
67MAP2K30.57591764
68KSR20.57550014
69PRPF4B0.57225690
70IKBKB0.56354473
71MAPK110.55262665
72ADRBK20.53613917
73CHEK20.52532816
74MTOR0.47706839
75ROCK10.47562972
76CHEK10.46841729
77PAK10.46542705
78PAK20.46237742
79MET0.44626632
80IRAK10.44159802
81AURKA0.43977093
82CDC70.43687273
83CDK120.43651573
84TRIB30.43428666
85CDK70.43333496
86MAP3K100.43074710
87TLK10.42651727
88MAP2K20.41186826
89MAP3K90.41075604
90ATR0.40269392
91DAPK30.37650831
92WEE10.37582044
93MAP2K60.35593734
94MATK0.35366696
95PKN10.35164197
96PAK40.34871017
97MAP3K130.34296433
98PINK10.34029942
99MARK20.33827251
100MAP3K140.32855386
101ATM0.32288650
102NTRK20.29981860
103CAMKK10.27026676
104LMTK20.26748512
105BRSK20.26196513
106IRAK20.23947294
107PRKAA10.22385316
108EPHB10.21862866
109MUSK0.19483507
110PRKCG0.18964177
111MAPKAPK50.15928053
112TAOK10.15541013
113ZAP700.14727023
114STK38L0.14698364
115RPS6KB10.12854534
116BRSK10.10875646
117PLK10.10491318
118PDGFRB0.09881066
119CDK60.09764577
120ERN10.09474851
121RPS6KA10.08999245
122PAK60.08357128
123CSF1R0.08293397
124STK100.08249822
125PRKCZ0.08189290
126PRKCQ0.07962557
127NEK60.07560742
128PTK60.07224116
129GSK3B0.06902731
130PIM10.06727982
131TTN0.06509647
132STK110.06316331
133CDK20.06210244
134CDK40.05593874
135BUB10.04897520
136EGFR0.04640362
137CSK0.04562111
138CDK10.04098019
139CDK150.04038053
140MAPK80.03974093
141CSNK1D0.03239388
142CSNK2A10.02287155
143MAP4K10.02207361
144CDK11A0.01821413
145CDK180.01460888
146MAPK10.01336273
147MARK30.00387070
148PRKDC0.00090435
149PRKACG-0.0200311
150PRKCD-0.0195991
151PRKG2-0.0175440
152CLK1-0.0138557
153PRKCB-0.0110897
154PLK4-0.0097338
155RIPK1-0.0097152
156CSNK2A2-0.0096922
157TBK1-0.0054984

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.41236187
2Fatty acid biosynthesis_Homo sapiens_hsa000614.35323906
3Pyruvate metabolism_Homo sapiens_hsa006203.40098258
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.06818316
5Vitamin B6 metabolism_Homo sapiens_hsa007503.06637399
6Sulfur relay system_Homo sapiens_hsa041223.05230178
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.98054541
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.82801704
9Linoleic acid metabolism_Homo sapiens_hsa005912.81350466
10Glucagon signaling pathway_Homo sapiens_hsa049222.74787162
11Other glycan degradation_Homo sapiens_hsa005112.73462579
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.59838179
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54409893
14Dorso-ventral axis formation_Homo sapiens_hsa043202.48785010
15Propanoate metabolism_Homo sapiens_hsa006402.35021274
16Selenocompound metabolism_Homo sapiens_hsa004502.31488443
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29554433
18Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.28125826
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.16922811
20Basal transcription factors_Homo sapiens_hsa030222.15176309
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.99592037
22Lysosome_Homo sapiens_hsa041421.96422126
23Glycerolipid metabolism_Homo sapiens_hsa005611.91874992
24Bladder cancer_Homo sapiens_hsa052191.87938203
25Fructose and mannose metabolism_Homo sapiens_hsa000511.83186494
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82020963
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.76282254
28PPAR signaling pathway_Homo sapiens_hsa033201.75347303
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.70908311
30Oocyte meiosis_Homo sapiens_hsa041141.69985763
31Pentose phosphate pathway_Homo sapiens_hsa000301.69277449
32Fanconi anemia pathway_Homo sapiens_hsa034601.64544241
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.61506188
34TNF signaling pathway_Homo sapiens_hsa046681.60081397
35Antigen processing and presentation_Homo sapiens_hsa046121.56919638
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.51365888
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47398777
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40838952
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35794528
40Prion diseases_Homo sapiens_hsa050201.34847868
41Amphetamine addiction_Homo sapiens_hsa050311.34050834
42mRNA surveillance pathway_Homo sapiens_hsa030151.32704481
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.32437338
44Fat digestion and absorption_Homo sapiens_hsa049751.29505018
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25026627
46Mineral absorption_Homo sapiens_hsa049781.24171279
47Fatty acid metabolism_Homo sapiens_hsa012121.23950818
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21885708
49Ether lipid metabolism_Homo sapiens_hsa005651.20648516
50RNA transport_Homo sapiens_hsa030131.20189175
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.19660150
52Fatty acid degradation_Homo sapiens_hsa000711.13972175
53Carbon metabolism_Homo sapiens_hsa012001.10771610
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09472650
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.05359056
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.04770726
57Osteoclast differentiation_Homo sapiens_hsa043801.04513676
58Renin secretion_Homo sapiens_hsa049241.03870174
59Notch signaling pathway_Homo sapiens_hsa043301.03278832
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03143406
61Pertussis_Homo sapiens_hsa051331.02926877
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01271340
63Malaria_Homo sapiens_hsa051440.99959047
64Cardiac muscle contraction_Homo sapiens_hsa042600.98561455
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98396239
66Axon guidance_Homo sapiens_hsa043600.93544592
67Acute myeloid leukemia_Homo sapiens_hsa052210.93288254
68Estrogen signaling pathway_Homo sapiens_hsa049150.92513642
69Hedgehog signaling pathway_Homo sapiens_hsa043400.91805351
70Huntingtons disease_Homo sapiens_hsa050160.91336397
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89728268
72Legionellosis_Homo sapiens_hsa051340.87260084
73mTOR signaling pathway_Homo sapiens_hsa041500.86888016
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.86434747
75Prolactin signaling pathway_Homo sapiens_hsa049170.85934550
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81832479
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81798631
78Purine metabolism_Homo sapiens_hsa002300.80643653
79ABC transporters_Homo sapiens_hsa020100.75516430
80Hepatitis B_Homo sapiens_hsa051610.71519325
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.71055619
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69758029
83Chronic myeloid leukemia_Homo sapiens_hsa052200.69675892
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.69649588
85African trypanosomiasis_Homo sapiens_hsa051430.69608060
86Galactose metabolism_Homo sapiens_hsa000520.68163349
87Endocytosis_Homo sapiens_hsa041440.68004998
88MAPK signaling pathway_Homo sapiens_hsa040100.67411240
89Gap junction_Homo sapiens_hsa045400.66614026
90Renin-angiotensin system_Homo sapiens_hsa046140.64994226
91Insulin secretion_Homo sapiens_hsa049110.64489297
92Arachidonic acid metabolism_Homo sapiens_hsa005900.64035694
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63629137
94Amoebiasis_Homo sapiens_hsa051460.62910429
95Thyroid hormone synthesis_Homo sapiens_hsa049180.62664821
96AMPK signaling pathway_Homo sapiens_hsa041520.62506011
97MicroRNAs in cancer_Homo sapiens_hsa052060.61334020
98VEGF signaling pathway_Homo sapiens_hsa043700.61307903
99Biosynthesis of amino acids_Homo sapiens_hsa012300.60531645
100Long-term potentiation_Homo sapiens_hsa047200.58897636
101ErbB signaling pathway_Homo sapiens_hsa040120.58199662
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57828002
103Apoptosis_Homo sapiens_hsa042100.56358783
104Focal adhesion_Homo sapiens_hsa045100.56124349
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.55071384
106Rheumatoid arthritis_Homo sapiens_hsa053230.54999387
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54815193
108Bile secretion_Homo sapiens_hsa049760.54651750
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54467042
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53882776
111Tuberculosis_Homo sapiens_hsa051520.53014800
112Insulin signaling pathway_Homo sapiens_hsa049100.52426304
113Glutathione metabolism_Homo sapiens_hsa004800.51317456
114B cell receptor signaling pathway_Homo sapiens_hsa046620.50200851
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49278226
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47237897
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45384219
118Protein digestion and absorption_Homo sapiens_hsa049740.45135687
119Renal cell carcinoma_Homo sapiens_hsa052110.43436354
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.42897710
121Systemic lupus erythematosus_Homo sapiens_hsa053220.41650696
122Hepatitis C_Homo sapiens_hsa051600.41319317
123Chemokine signaling pathway_Homo sapiens_hsa040620.40940261
124Arginine and proline metabolism_Homo sapiens_hsa003300.40707480
125Inositol phosphate metabolism_Homo sapiens_hsa005620.40368070
126Glioma_Homo sapiens_hsa052140.39285868
127Pancreatic secretion_Homo sapiens_hsa049720.38937771
128Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38802651
129Calcium signaling pathway_Homo sapiens_hsa040200.38656750
130Phagosome_Homo sapiens_hsa041450.37972079
131Collecting duct acid secretion_Homo sapiens_hsa049660.37296456
132Chemical carcinogenesis_Homo sapiens_hsa052040.36738866
133Proteoglycans in cancer_Homo sapiens_hsa052050.36071075
134Influenza A_Homo sapiens_hsa051640.35589766
135Cholinergic synapse_Homo sapiens_hsa047250.34870740
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.34066067
137Measles_Homo sapiens_hsa051620.33597629
138Toxoplasmosis_Homo sapiens_hsa051450.33291719
139Salivary secretion_Homo sapiens_hsa049700.31813223
140Vibrio cholerae infection_Homo sapiens_hsa051100.31526365
141Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31291896
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.31226201
143N-Glycan biosynthesis_Homo sapiens_hsa005100.31004756
144Viral carcinogenesis_Homo sapiens_hsa052030.29661811
145Salmonella infection_Homo sapiens_hsa051320.27453153
146Insulin resistance_Homo sapiens_hsa049310.25722832
147Type II diabetes mellitus_Homo sapiens_hsa049300.25305501
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24879371
149HIF-1 signaling pathway_Homo sapiens_hsa040660.24548085
150Gastric acid secretion_Homo sapiens_hsa049710.24118619
151Basal cell carcinoma_Homo sapiens_hsa052170.22401118
152Epstein-Barr virus infection_Homo sapiens_hsa051690.20989528
153Cocaine addiction_Homo sapiens_hsa050300.20652107
154cAMP signaling pathway_Homo sapiens_hsa040240.20617544
155Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19144644
156Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17636657
157Alcoholism_Homo sapiens_hsa050340.17437481
158Synaptic vesicle cycle_Homo sapiens_hsa047210.14079366
159Sphingolipid metabolism_Homo sapiens_hsa006000.13859409
160Taste transduction_Homo sapiens_hsa047420.13641532

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