GFRAL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)7.55535204
2regulation of penile erection (GO:0060405)5.88534745
3regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.82751041
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.76768548
5neuron cell-cell adhesion (GO:0007158)5.63225446
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.63010025
7behavioral response to nicotine (GO:0035095)5.53596976
8behavioral response to cocaine (GO:0048148)5.13352399
9postsynaptic membrane organization (GO:0001941)5.10261061
10norepinephrine metabolic process (GO:0042415)4.95495833
11presynaptic membrane assembly (GO:0097105)4.93578843
12vocalization behavior (GO:0071625)4.87490713
13limb bud formation (GO:0060174)4.82706886
14behavioral response to ethanol (GO:0048149)4.81413641
15positive regulation of mitochondrial membrane permeability (GO:0035794)4.78826679
16response to histamine (GO:0034776)4.66826620
17fucose catabolic process (GO:0019317)4.61306142
18L-fucose metabolic process (GO:0042354)4.61306142
19L-fucose catabolic process (GO:0042355)4.61306142
20short-term memory (GO:0007614)4.54015146
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.27646646
22regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.25300386
23regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.25300386
24cellular response to zinc ion (GO:0071294)4.22369379
25lateral sprouting from an epithelium (GO:0060601)4.22255238
26chemosensory behavior (GO:0007635)4.17838135
27regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.11681757
28positive regulation of dendritic spine development (GO:0060999)4.08157353
29behavioral defense response (GO:0002209)3.98621125
30behavioral fear response (GO:0001662)3.98621125
31synaptic vesicle maturation (GO:0016188)3.96453101
32synaptic transmission, dopaminergic (GO:0001963)3.93935172
33presynaptic membrane organization (GO:0097090)3.92340686
34cardiac left ventricle morphogenesis (GO:0003214)3.81744785
35tryptophan catabolic process (GO:0006569)3.78103594
36indole-containing compound catabolic process (GO:0042436)3.78103594
37indolalkylamine catabolic process (GO:0046218)3.78103594
38regulation of dendritic spine development (GO:0060998)3.76226238
39G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.74035230
40positive regulation of membrane potential (GO:0045838)3.67914699
41negative regulation of adenylate cyclase activity (GO:0007194)3.61552279
42fear response (GO:0042596)3.61041144
43prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.50777354
44indolalkylamine metabolic process (GO:0006586)3.48872457
45regulation of glutamate receptor signaling pathway (GO:1900449)3.46094352
46positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.45165816
47mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.45165816
48gamma-aminobutyric acid transport (GO:0015812)3.44042558
49regulation of synaptic transmission, dopaminergic (GO:0032225)3.43948603
50negative regulation of cyclase activity (GO:0031280)3.42819484
51regulation of action potential (GO:0098900)3.42128856
52regulation of cilium movement (GO:0003352)3.41202982
53negative regulation of homotypic cell-cell adhesion (GO:0034111)3.40550689
54kynurenine metabolic process (GO:0070189)3.40094520
55ubiquinone biosynthetic process (GO:0006744)3.38401771
56embryonic skeletal joint morphogenesis (GO:0060272)3.36281370
57glutathione biosynthetic process (GO:0006750)3.35515155
58cullin deneddylation (GO:0010388)3.32083230
59platelet dense granule organization (GO:0060155)3.30733149
60nonmotile primary cilium assembly (GO:0035058)3.30613509
61negative regulation of lyase activity (GO:0051350)3.29510350
62cellular biogenic amine catabolic process (GO:0042402)3.28979146
63amine catabolic process (GO:0009310)3.28979146
64water-soluble vitamin biosynthetic process (GO:0042364)3.28864310
65positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.28832180
66membrane hyperpolarization (GO:0060081)3.27229518
67negative regulation of epidermal cell differentiation (GO:0045605)3.26991918
68regulation of dopamine metabolic process (GO:0042053)3.26810532
69regulation of catecholamine metabolic process (GO:0042069)3.26810532
70mesonephros development (GO:0001823)3.26377742
71negative regulation of telomere maintenance (GO:0032205)3.25408571
72ubiquinone metabolic process (GO:0006743)3.23714111
73epithelial cell differentiation involved in prostate gland development (GO:0060742)3.23201531
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22490025
75pyrimidine nucleobase catabolic process (GO:0006208)3.21824548
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20525651
77synaptic vesicle exocytosis (GO:0016079)3.19508230
78regulation of neurotransmitter uptake (GO:0051580)3.19227969
79positive regulation of neurotransmitter transport (GO:0051590)3.18200717
80negative regulation of execution phase of apoptosis (GO:1900118)3.17874392
81membrane assembly (GO:0071709)3.16152093
82serotonin metabolic process (GO:0042428)3.13725400
83reflex (GO:0060004)3.11727876
84nonribosomal peptide biosynthetic process (GO:0019184)3.10278978
85negative regulation of cAMP metabolic process (GO:0030815)3.09410469
86protein polyglutamylation (GO:0018095)3.08894323
87tryptophan metabolic process (GO:0006568)3.08168941
88regulation of mitochondrial depolarization (GO:0051900)3.07330725
89organ induction (GO:0001759)3.06275892
90protein-cofactor linkage (GO:0018065)3.03772633
91lung lobe morphogenesis (GO:0060463)3.02891279
92response to pheromone (GO:0019236)3.00902025
93positive regulation of action potential (GO:0045760)2.99934849
94cellular ketone body metabolic process (GO:0046950)2.99536727
95tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99014347
96RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99014347
97negative regulation of cyclic nucleotide metabolic process (GO:0030800)2.98054890
98catecholamine metabolic process (GO:0006584)2.97703139
99catechol-containing compound metabolic process (GO:0009712)2.97703139
100positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97265370
101protein deneddylation (GO:0000338)2.95851753
102negative regulation of cAMP biosynthetic process (GO:0030818)2.95659532
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.92857671
104nucleobase catabolic process (GO:0046113)2.92561252
105synaptic transmission, cholinergic (GO:0007271)2.92265410
106respiratory chain complex IV assembly (GO:0008535)2.89923377
107response to epinephrine (GO:0071871)2.88994888
108cell migration in hindbrain (GO:0021535)2.88912909
109regulation of microtubule-based movement (GO:0060632)2.87534144
110positive regulation of protein export from nucleus (GO:0046827)2.87441164
111detection of light stimulus involved in sensory perception (GO:0050962)2.86149626
112detection of light stimulus involved in visual perception (GO:0050908)2.86149626
113neural tube formation (GO:0001841)2.85349853
114epithelial cilium movement (GO:0003351)2.85129557
115DNA deamination (GO:0045006)2.84568236
116negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.83669085
117cornea development in camera-type eye (GO:0061303)2.82378290
118alanine transport (GO:0032328)2.82094847
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79364724
120regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78807978
121protein complex biogenesis (GO:0070271)2.78379560
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.78361772
123NADH dehydrogenase complex assembly (GO:0010257)2.78361772
124mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78361772
125regulation of nuclear cell cycle DNA replication (GO:0033262)2.77280458
126preassembly of GPI anchor in ER membrane (GO:0016254)2.77163714
127cilium morphogenesis (GO:0060271)2.76473199
128indole-containing compound metabolic process (GO:0042430)2.75760093
129regulation of voltage-gated calcium channel activity (GO:1901385)2.75435396
130induction of positive chemotaxis (GO:0050930)2.75347095
131ketone body metabolic process (GO:1902224)2.75249764
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.74774168
133regulation of excitatory postsynaptic membrane potential (GO:0060079)2.74698107
134regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.74065536
135positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.73637408
136positive regulation of sodium ion transmembrane transport (GO:1902307)2.70744157
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70102225
138dopamine metabolic process (GO:0042417)2.70036232
139proline transport (GO:0015824)2.69351057
140negative regulation of oligodendrocyte differentiation (GO:0048715)2.68773930
141glycerophospholipid catabolic process (GO:0046475)2.67872280
142positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.66931350
143fucosylation (GO:0036065)2.66606103
144muscle cell cellular homeostasis (GO:0046716)2.66274322
145response to misfolded protein (GO:0051788)2.65907054
146neuronal action potential (GO:0019228)2.65818033
147kidney morphogenesis (GO:0060993)2.65500180
148quinone biosynthetic process (GO:1901663)2.64692239
149mitochondrial respiratory chain complex assembly (GO:0033108)2.64059344
150negative regulation of nucleotide biosynthetic process (GO:0030809)2.63810356
151negative regulation of purine nucleotide biosynthetic process (GO:1900372)2.63810356
152neurotransmitter-gated ion channel clustering (GO:0072578)2.61717074
153cytochrome complex assembly (GO:0017004)2.61528150
154neuronal action potential propagation (GO:0019227)2.60599006
155neuron-neuron synaptic transmission (GO:0007270)2.60071353
156nephron tubule morphogenesis (GO:0072078)2.59611845
157nephron epithelium morphogenesis (GO:0072088)2.59611845
158activation of protein kinase B activity (GO:0032148)2.58094415
159long-chain fatty acid biosynthetic process (GO:0042759)2.57878161
160enteric nervous system development (GO:0048484)2.57803860
161regulation of synapse organization (GO:0050807)2.57723744
162sulfation (GO:0051923)2.57320404
163desmosome organization (GO:0002934)2.57304886
164G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.57291977
165negative regulation of microtubule polymerization (GO:0031115)2.57264279
166dopamine receptor signaling pathway (GO:0007212)2.57049372
167protein localization to synapse (GO:0035418)2.56907845
168positive regulation of fatty acid transport (GO:2000193)2.56203684
169auditory behavior (GO:0031223)2.51917136
170primary amino compound metabolic process (GO:1901160)2.51917008
171negative regulation of transcription by competitive promoter binding (GO:0010944)2.51837711
172cilium organization (GO:0044782)2.51104424
173dendritic spine morphogenesis (GO:0060997)2.50051489
174negative regulation of Ras protein signal transduction (GO:0046580)2.49687713
175positive regulation of prostaglandin secretion (GO:0032308)2.47120047
176regulation of postsynaptic membrane potential (GO:0060078)2.46837098
177cilium assembly (GO:0042384)2.46272919
178smooth muscle cell differentiation (GO:0051145)2.46075854
179peristalsis (GO:0030432)2.44930468
180cellular response to interferon-alpha (GO:0035457)2.44832615
181regulation of hexokinase activity (GO:1903299)2.43901675
182regulation of glucokinase activity (GO:0033131)2.43901675
183exogenous drug catabolic process (GO:0042738)2.43355977
184retinal cone cell development (GO:0046549)2.42331336
185negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41396614
186negative regulation of mast cell activation (GO:0033004)2.41084115
187inositol phosphate catabolic process (GO:0071545)2.39197038
188sperm motility (GO:0030317)2.39037338
189piRNA metabolic process (GO:0034587)2.38619236
190mitochondrion morphogenesis (GO:0070584)2.38206484
191ATP synthesis coupled proton transport (GO:0015986)2.38158681
192energy coupled proton transport, down electrochemical gradient (GO:0015985)2.38158681
193axoneme assembly (GO:0035082)2.37178715
194aromatic amino acid family catabolic process (GO:0009074)2.36990277
195auditory receptor cell stereocilium organization (GO:0060088)2.35415057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.70896873
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.77712398
3EZH2_22144423_ChIP-Seq_EOC_Human4.68291845
4VDR_22108803_ChIP-Seq_LS180_Human3.29619956
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11340492
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.94542565
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.93824962
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.86816575
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.82139249
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.81675843
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.73438661
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71457052
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69055569
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.64309564
15IGF1R_20145208_ChIP-Seq_DFB_Human2.59677033
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54544725
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51325595
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.48074773
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46807014
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46807014
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.39086644
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35418659
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28620889
24ZNF263_19887448_ChIP-Seq_K562_Human2.28465615
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20975733
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16854331
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13067668
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.09134328
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06323733
30* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91454195
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.91441160
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87003367
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.81280393
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.78303574
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.76805544
36TP53_22573176_ChIP-Seq_HFKS_Human1.75780528
37EWS_26573619_Chip-Seq_HEK293_Human1.75177730
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69875736
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69380493
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.66104074
41GBX2_23144817_ChIP-Seq_PC3_Human1.65872362
42ER_23166858_ChIP-Seq_MCF-7_Human1.58746250
43P300_19829295_ChIP-Seq_ESCs_Human1.56687997
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.56586422
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56438154
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55849061
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53401070
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.53082989
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.47796515
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47380555
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46996395
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43878511
53REST_21632747_ChIP-Seq_MESCs_Mouse1.42364262
54AHR_22903824_ChIP-Seq_MCF-7_Human1.41280534
55IRF1_19129219_ChIP-ChIP_H3396_Human1.41129703
56POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40942883
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40942883
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39929521
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39926883
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.38323085
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35846015
62CBP_20019798_ChIP-Seq_JUKART_Human1.35846015
63TP53_18474530_ChIP-ChIP_U2OS_Human1.35825020
64* RNF2_27304074_Chip-Seq_NSC_Mouse1.34715613
65MYC_18940864_ChIP-ChIP_HL60_Human1.34301348
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34002017
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.33280545
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32717992
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32607295
70SOX2_19829295_ChIP-Seq_ESCs_Human1.31628247
71NANOG_19829295_ChIP-Seq_ESCs_Human1.31628247
72STAT3_23295773_ChIP-Seq_U87_Human1.31615072
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28631522
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28413560
75AR_25329375_ChIP-Seq_VCAP_Human1.27566331
76* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27178000
77* FOXA1_25329375_ChIP-Seq_VCAP_Human1.26450667
78* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.26450667
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26054089
80ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25276006
81NCOR_22424771_ChIP-Seq_293T_Human1.23911642
82* TCF4_23295773_ChIP-Seq_U87_Human1.22018737
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21949910
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.20751583
85EST1_17652178_ChIP-ChIP_JURKAT_Human1.20120553
86HOXB7_26014856_ChIP-Seq_BT474_Human1.17586175
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16861341
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16008476
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15910795
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14797832
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14598605
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12335552
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12189346
94* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11498732
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11241564
96TAF15_26573619_Chip-Seq_HEK293_Human1.10295771
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.09678060
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07374019
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05411187
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.05200619
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03815068
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03584450
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.02927819
104TP53_20018659_ChIP-ChIP_R1E_Mouse1.02779967
105AR_21572438_ChIP-Seq_LNCaP_Human1.02210970
106MYC_19829295_ChIP-Seq_ESCs_Human1.01687524
107SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01681548
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.01613022
109REST_18959480_ChIP-ChIP_MESCs_Mouse1.01557701
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01521608
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.00135992
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99798608
113ERA_21632823_ChIP-Seq_H3396_Human0.99595737
114AR_20517297_ChIP-Seq_VCAP_Human0.99242750
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.98805397
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98409661
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.98166423
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.97809935
119* FUS_26573619_Chip-Seq_HEK293_Human0.97274190
120CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94896265
121NANOG_20526341_ChIP-Seq_ESCs_Human0.93032521
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.92334379
123BCAT_22108803_ChIP-Seq_LS180_Human0.91921417
124RING1B_27294783_Chip-Seq_ESCs_Mouse0.91714486
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91632213
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.90344565
127RXR_22108803_ChIP-Seq_LS180_Human0.89965568
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.89328936
129TCF4_22108803_ChIP-Seq_LS180_Human0.88275373
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87446969
131KDM2B_26808549_Chip-Seq_REH_Human0.87082402
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86155407
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84577514
134SMAD4_21799915_ChIP-Seq_A2780_Human0.83867781
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.82834865
136DROSHA_22980978_ChIP-Seq_HELA_Human0.82190931
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.82161826
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81595283
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.80820056
140RARB_27405468_Chip-Seq_BRAIN_Mouse0.80694488
141SMAD4_21741376_ChIP-Seq_HESCs_Human0.80318576
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.80260089
143WT1_19549856_ChIP-ChIP_CCG9911_Human0.79992495
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78759903
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78560414
146* RUNX2_22187159_ChIP-Seq_PCA_Human0.77715990
147SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77191047
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.76552967
149AR_19668381_ChIP-Seq_PC3_Human0.75213130
150ZNF274_21170338_ChIP-Seq_K562_Hela0.73832639
151TAL1_26923725_Chip-Seq_HPCs_Mouse0.73695014
152FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73575285
153SOX9_24532713_ChIP-Seq_HFSC_Mouse0.71384151
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70668490
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.69777345
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.68750968
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68590893

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.33098611
2MP0004381_abnormal_hair_follicle5.83233384
3MP0000383_abnormal_hair_follicle4.04826789
4MP0003879_abnormal_hair_cell3.59203694
5MP0002163_abnormal_gland_morphology3.18155842
6MP0000372_irregular_coat_pigmentation3.17768203
7MP0005409_darkened_coat_color3.06327630
8MP0010678_abnormal_skin_adnexa2.93524457
9MP0006292_abnormal_olfactory_placode2.86724053
10MP0002132_abnormal_respiratory_system2.63385843
11MP0000566_synostosis2.58929542
12MP0003195_calcinosis2.57472304
13MP0002090_abnormal_vision2.56004064
14MP0005645_abnormal_hypothalamus_physiol2.53961872
15MP0002277_abnormal_respiratory_mucosa2.45476276
16MP0003011_delayed_dark_adaptation2.42259357
17MP0003122_maternal_imprinting2.32451466
18MP0008877_abnormal_DNA_methylation2.31366231
19MP0002653_abnormal_ependyma_morphology2.31098174
20MP0005379_endocrine/exocrine_gland_phen2.22661003
21MP0004043_abnormal_pH_regulation2.21336526
22MP0004859_abnormal_synaptic_plasticity2.13845290
23MP0002638_abnormal_pupillary_reflex2.07264434
24MP0001529_abnormal_vocalization2.06559981
25MP0005551_abnormal_eye_electrophysiolog2.04942107
26MP0010030_abnormal_orbit_morphology2.03238286
27MP0004142_abnormal_muscle_tone1.96289617
28MP0003880_abnormal_central_pattern1.92034392
29MP0004133_heterotaxia1.91432972
30MP0001501_abnormal_sleep_pattern1.90129274
31MP0003787_abnormal_imprinting1.87302848
32MP0005187_abnormal_penis_morphology1.84958389
33MP0008872_abnormal_physiological_respon1.83638590
34MP0000569_abnormal_digit_pigmentation1.80179988
35MP0005646_abnormal_pituitary_gland1.77263618
36MP0002876_abnormal_thyroid_physiology1.75562869
37MP0003646_muscle_fatigue1.71183678
38MP0001502_abnormal_circadian_rhythm1.70457373
39MP0009046_muscle_twitch1.69798049
40MP0004858_abnormal_nervous_system1.67899658
41MP0005253_abnormal_eye_physiology1.67869194
42MP0000647_abnormal_sebaceous_gland1.66484081
43MP0002733_abnormal_thermal_nociception1.64238901
44MP0000778_abnormal_nervous_system1.63687400
45MP0005451_abnormal_body_composition1.62429444
46MP0003635_abnormal_synaptic_transmissio1.62247145
47MP0005408_hypopigmentation1.61290490
48MP0001485_abnormal_pinna_reflex1.58577632
49MP0003828_pulmonary_edema1.58371202
50MP0004147_increased_porphyrin_level1.58367924
51MP0006276_abnormal_autonomic_nervous1.57600564
52MP0005084_abnormal_gallbladder_morpholo1.56138755
53MP0006072_abnormal_retinal_apoptosis1.55640094
54MP0000631_abnormal_neuroendocrine_gland1.53404616
55MP0002063_abnormal_learning/memory/cond1.51763347
56MP0002282_abnormal_trachea_morphology1.46558606
57MP0003121_genomic_imprinting1.46102585
58MP0009745_abnormal_behavioral_response1.45792978
59MP0002064_seizures1.43763380
60MP0003938_abnormal_ear_development1.43755908
61MP0002572_abnormal_emotion/affect_behav1.43285810
62MP0001970_abnormal_pain_threshold1.39635069
63MP0002938_white_spotting1.38179770
64MP0002837_dystrophic_cardiac_calcinosis1.37466063
65MP0002184_abnormal_innervation1.34885407
66MP0004270_analgesia1.26700485
67MP0002909_abnormal_adrenal_gland1.23781897
68MP0002254_reproductive_system_inflammat1.22397734
69MP0002272_abnormal_nervous_system1.18257269
70MP0002928_abnormal_bile_duct1.18146782
71MP0002160_abnormal_reproductive_system1.18126950
72MP0000049_abnormal_middle_ear1.16723840
73MP0005389_reproductive_system_phenotype1.15973656
74MP0001986_abnormal_taste_sensitivity1.15028903
75MP0002295_abnormal_pulmonary_circulatio1.14855458
76MP0005623_abnormal_meninges_morphology1.13521746
77MP0001919_abnormal_reproductive_system1.12042247
78MP0001188_hyperpigmentation1.10983972
79MP0000427_abnormal_hair_cycle1.07414439
80MP0005167_abnormal_blood-brain_barrier1.07069190
81MP0001905_abnormal_dopamine_level1.06073898
82MP0005360_urolithiasis1.04672434
83MP0010386_abnormal_urinary_bladder1.02711497
84MP0009115_abnormal_fat_cell1.02581017
85MP0005083_abnormal_biliary_tract1.02233506
86MP0005195_abnormal_posterior_eye1.01182157
87MP0008789_abnormal_olfactory_epithelium1.00886081
88MP0002752_abnormal_somatic_nervous0.99500225
89MP0002102_abnormal_ear_morphology0.97751674
90MP0001984_abnormal_olfaction0.97525256
91MP0008995_early_reproductive_senescence0.96901136
92MP0001666_abnormal_nutrient_absorption0.96542736
93MP0002234_abnormal_pharynx_morphology0.95054813
94MP0001486_abnormal_startle_reflex0.95014923
95MP0005595_abnormal_vascular_smooth0.94682691
96MP0000026_abnormal_inner_ear0.92754492
97MP0002332_abnormal_exercise_endurance0.91735653
98MP0002557_abnormal_social/conspecific_i0.91394599
99MP0010234_abnormal_vibrissa_follicle0.91370469
100MP0004145_abnormal_muscle_electrophysio0.91335065
101MP0005394_taste/olfaction_phenotype0.90127489
102MP0005499_abnormal_olfactory_system0.90127489
103MP0002751_abnormal_autonomic_nervous0.88749475
104MP0002229_neurodegeneration0.88447961
105MP0003119_abnormal_digestive_system0.87856092
106MP0001346_abnormal_lacrimal_gland0.86990412
107MP0000579_abnormal_nail_morphology0.86833657
108MP0002098_abnormal_vibrissa_morphology0.86696747
109MP0004742_abnormal_vestibular_system0.86114872
110MP0009379_abnormal_foot_pigmentation0.86102116
111MP0009250_abnormal_appendicular_skeleto0.85228565
112MP0005365_abnormal_bile_salt0.84269707
113MP0003718_maternal_effect0.83566910
114MP0001958_emphysema0.83238734
115MP0009384_cardiac_valve_regurgitation0.83152589
116MP0002882_abnormal_neuron_morphology0.82880506
117MP0001968_abnormal_touch/_nociception0.82817369
118MP0004215_abnormal_myocardial_fiber0.82582069
119MP0004085_abnormal_heartbeat0.81167327
120MP0003878_abnormal_ear_physiology0.78827902
121MP0005377_hearing/vestibular/ear_phenot0.78827902
122MP0000920_abnormal_myelination0.77810606
123MP0003283_abnormal_digestive_organ0.77642927
124MP0002067_abnormal_sensory_capabilities0.77375176
125MP0009780_abnormal_chondrocyte_physiolo0.77301687
126MP0000762_abnormal_tongue_morphology0.76525416
127MP0001177_atelectasis0.75370606
128MP0005085_abnormal_gallbladder_physiolo0.74179837
129MP0004885_abnormal_endolymph0.73498955
130MP0000467_abnormal_esophagus_morphology0.71951823
131MP0002734_abnormal_mechanical_nocicepti0.71839664
132MP0002108_abnormal_muscle_morphology0.70427223
133MP0000537_abnormal_urethra_morphology0.70272173
134MP0002133_abnormal_respiratory_system0.69791494
135MP0005388_respiratory_system_phenotype0.69791494
136MP0001440_abnormal_grooming_behavior0.68493385
137MP0004811_abnormal_neuron_physiology0.68391287
138MP0004019_abnormal_vitamin_homeostasis0.67079632
139MP0001963_abnormal_hearing_physiology0.65786099
140MP0005386_behavior/neurological_phenoty0.65262190
141MP0004924_abnormal_behavior0.65262190
142MP0003329_amyloid_beta_deposits0.65004765
143MP0002735_abnormal_chemical_nociception0.64910298
144MP0008874_decreased_physiological_sensi0.64435972
145MP0000230_abnormal_systemic_arterial0.63046205
146MP0002822_catalepsy0.61683510
147MP0004510_myositis0.60554891
148MP0002127_abnormal_cardiovascular_syste0.59429838
149MP0002736_abnormal_nociception_after0.58987522
150MP0008875_abnormal_xenobiotic_pharmacok0.58504097
151MP0009764_decreased_sensitivity_to0.58118890
152MP0002069_abnormal_eating/drinking_beha0.57393366

Predicted human phenotypes

RankGene SetZ-score
1Upper limb muscle weakness (HP:0003484)5.55509308
2Humeroradial synostosis (HP:0003041)5.19079298
3Synostosis involving the elbow (HP:0003938)5.19079298
4Nasolacrimal duct obstruction (HP:0000579)4.90196891
5Conical tooth (HP:0000698)4.68866134
6Premature skin wrinkling (HP:0100678)4.62024739
7Short chin (HP:0000331)4.55655282
8Absent eyebrow (HP:0002223)4.45437819
9Aplasia involving bones of the extremities (HP:0009825)4.31701573
10Aplasia involving bones of the upper limbs (HP:0009823)4.31701573
11Aplasia of the phalanges of the hand (HP:0009802)4.31701573
12Pancreatic cysts (HP:0001737)4.25406107
13Abnormality of the lacrimal duct (HP:0011481)4.20894831
14Abnormality of midbrain morphology (HP:0002418)4.15515789
15Molar tooth sign on MRI (HP:0002419)4.15515789
16True hermaphroditism (HP:0010459)3.99189464
17Concave nail (HP:0001598)3.85811269
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.84676356
19Abnormality of alanine metabolism (HP:0010916)3.84676356
20Hyperalaninemia (HP:0003348)3.84676356
21Pancreatic fibrosis (HP:0100732)3.83510224
22Microglossia (HP:0000171)3.82780695
23Abnormality of the nasolacrimal system (HP:0000614)3.82753505
24Congenital stationary night blindness (HP:0007642)3.74535460
25Anteriorly placed anus (HP:0001545)3.62123692
26Nephronophthisis (HP:0000090)3.61613195
27Respiratory difficulties (HP:0002880)3.60981412
28Type II lissencephaly (HP:0007260)3.54906207
29Aplasia cutis congenita (HP:0001057)3.30957055
30Abnormality of the dental root (HP:0006486)3.30835268
31Taurodontia (HP:0000679)3.30835268
32Abnormality of permanent molar morphology (HP:0011071)3.30835268
33Focal motor seizures (HP:0011153)3.29797145
34Oligodontia (HP:0000677)3.25697121
35Tetraparesis (HP:0002273)3.23433781
36Cerebellar dysplasia (HP:0007033)3.21337398
37Abnormality of molar (HP:0011077)3.21142699
38Abnormality of molar morphology (HP:0011070)3.21142699
39Hypoplastic nipples (HP:0002557)3.19929587
40Choanal stenosis (HP:0000452)3.18856785
41Alopecia of scalp (HP:0002293)3.17548564
42Morphological abnormality of the middle ear (HP:0008609)3.11607347
43Abnormality of the renal medulla (HP:0100957)3.04493037
44Hyperlipoproteinemia (HP:0010980)2.91389646
45Abnormality of the dental pulp (HP:0006479)2.90286247
46Symphalangism affecting the phalanges of the hand (HP:0009773)2.88306310
47Hyperventilation (HP:0002883)2.85142111
48Epileptic encephalopathy (HP:0200134)2.84116858
49Partial duplication of thumb phalanx (HP:0009944)2.80856717
50Prominent supraorbital ridges (HP:0000336)2.79847371
51Large for gestational age (HP:0001520)2.79277669
52Medial flaring of the eyebrow (HP:0010747)2.78284981
53Impaired vibration sensation in the lower limbs (HP:0002166)2.70886283
54Xerostomia (HP:0000217)2.70484625
55Abnormal pupillary function (HP:0007686)2.67818218
56Adrenal hypoplasia (HP:0000835)2.67587624
57Abnormality of the nasal septum (HP:0000419)2.66127704
58Relative macrocephaly (HP:0004482)2.65493543
59Severe muscular hypotonia (HP:0006829)2.64318438
60Chronic otitis media (HP:0000389)2.61972536
61Short tibia (HP:0005736)2.61593858
62Hypoplasia of the pons (HP:0012110)2.60845222
63Attenuation of retinal blood vessels (HP:0007843)2.60700848
64Absent hair (HP:0002298)2.60331525
65Decreased central vision (HP:0007663)2.59700888
66Inability to walk (HP:0002540)2.59550962
67Acute necrotizing encephalopathy (HP:0006965)2.58570682
68Cystic liver disease (HP:0006706)2.58341193
69Abnormality of the renal cortex (HP:0011035)2.57026695
70Sclerocornea (HP:0000647)2.55943328
71Anhidrosis (HP:0000970)2.55938007
72Dysphonia (HP:0001618)2.54643605
73Furrowed tongue (HP:0000221)2.52879093
74Abolished electroretinogram (ERG) (HP:0000550)2.52308743
75Turricephaly (HP:0000262)2.50925181
76Abnormality of cells of the erythroid lineage (HP:0012130)2.49990676
77Partial duplication of the phalanx of hand (HP:0009999)2.49458347
78Lissencephaly (HP:0001339)2.49075618
79Stenosis of the external auditory canal (HP:0000402)2.47595142
80Chronic hepatic failure (HP:0100626)2.47401259
81Increased CSF lactate (HP:0002490)2.46983433
82Brittle hair (HP:0002299)2.44915497
83Prolonged partial thromboplastin time (HP:0003645)2.44817100
84Thick nail (HP:0001805)2.43036469
85Septate vagina (HP:0001153)2.43006539
86Abnormality of the pons (HP:0007361)2.42067217
87Visual hallucinations (HP:0002367)2.34970143
88Mitochondrial inheritance (HP:0001427)2.34732020
89Hypomagnesemia (HP:0002917)2.33501031
90Abnormal rod and cone electroretinograms (HP:0008323)2.32263241
91Congenital, generalized hypertrichosis (HP:0004540)2.30473547
92Degeneration of the lateral corticospinal tracts (HP:0002314)2.29958575
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.29958575
94Type I diabetes mellitus (HP:0100651)2.29849377
95Broad-based gait (HP:0002136)2.29738942
96Renal cortical cysts (HP:0000803)2.28969192
97Pachygyria (HP:0001302)2.28901721
98Gait imbalance (HP:0002141)2.28807661
99Methylmalonic aciduria (HP:0012120)2.28136878
100Keratoconus (HP:0000563)2.27901653
101Increased corneal curvature (HP:0100692)2.27901653
102Thickened helices (HP:0000391)2.26979957
103Long foot (HP:0001833)2.26495108
104Anencephaly (HP:0002323)2.26483764
105Abnormality of salivation (HP:0100755)2.26382862
106Progressive cerebellar ataxia (HP:0002073)2.25814708
107Decreased electroretinogram (ERG) amplitude (HP:0000654)2.25422728
108Polyphagia (HP:0002591)2.25301157
109Abnormality of the labia minora (HP:0012880)2.24677636
110Abnormal number of erythroid precursors (HP:0012131)2.24492626
111Aplasia/hypoplasia of the uterus (HP:0008684)2.23997988
112Aplasia/Hypoplasia of the tibia (HP:0005772)2.22605279
113Acute encephalopathy (HP:0006846)2.20662835
114Progressive macrocephaly (HP:0004481)2.20025826
115Pendular nystagmus (HP:0012043)2.18839425
116Absent/shortened dynein arms (HP:0200106)2.15751972
117Dynein arm defect of respiratory motile cilia (HP:0012255)2.15751972
118Xanthomatosis (HP:0000991)2.12288036
119Tubular atrophy (HP:0000092)2.11046311
120Recurrent corneal erosions (HP:0000495)2.10966838
121Hepatic necrosis (HP:0002605)2.10755807
122Methylmalonic acidemia (HP:0002912)2.10684655
123Abnormal mitochondria in muscle tissue (HP:0008316)2.10320796
124Hepatocellular necrosis (HP:0001404)2.09092789
125Congenital primary aphakia (HP:0007707)2.09032880
126Genetic anticipation (HP:0003743)2.07494074
127Abnormal drinking behavior (HP:0030082)2.07277592
128Polydipsia (HP:0001959)2.07277592
129Status epilepticus (HP:0002133)2.05395349
130Hypotrichosis (HP:0001006)2.05153160
131Excessive salivation (HP:0003781)2.04331980
132Drooling (HP:0002307)2.04331980
133Distal lower limb amyotrophy (HP:0008944)2.03302745
134Abnormality of the musculature of the hand (HP:0001421)2.02993127
135Clitoromegaly (HP:0000057)2.02583153
136Myokymia (HP:0002411)2.02313634
137Alacrima (HP:0000522)2.01336976
138Optic disc pallor (HP:0000543)2.00788214
139Optic nerve hypoplasia (HP:0000609)2.00389534
140Termporal pattern (HP:0011008)2.00385375
141Insidious onset (HP:0003587)2.00385375
142Absent septum pellucidum (HP:0001331)1.99610724
1433-Methylglutaconic aciduria (HP:0003535)1.99437322
144Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97853772
145Abnormality of the corticospinal tract (HP:0002492)1.97382222
146Nephrogenic diabetes insipidus (HP:0009806)1.96654178
147Oligodactyly (hands) (HP:0001180)1.96288795
148Retinal dysplasia (HP:0007973)1.95861693
149Parakeratosis (HP:0001036)1.95442414
150Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.95095188
151Cholelithiasis (HP:0001081)1.94388358
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.93738327
153Lipid accumulation in hepatocytes (HP:0006561)1.91993933
154Male pseudohermaphroditism (HP:0000037)1.91119701
155Split foot (HP:0001839)1.91056499
156Pallor (HP:0000980)1.89060497
157Progressive inability to walk (HP:0002505)1.88266015
158Congenital hepatic fibrosis (HP:0002612)1.85212598
159Atonic seizures (HP:0010819)1.85155897
160Abnormality of the parietal bone (HP:0002696)1.85037060
161Abnormality of macular pigmentation (HP:0008002)1.84672417
162Shallow orbits (HP:0000586)1.84426293
163Hypoplasia of the fovea (HP:0007750)1.84030612
164Aplasia/Hypoplasia of the fovea (HP:0008060)1.84030612
165Neuroendocrine neoplasm (HP:0100634)1.83631821
166Abnormal biliary tract physiology (HP:0012439)1.83457411
167Bile duct proliferation (HP:0001408)1.83457411
168Occipital encephalocele (HP:0002085)1.83174914
169Neuronal loss in central nervous system (HP:0002529)1.82459120
170Agitation (HP:0000713)1.81808872
171Macrocytic anemia (HP:0001972)1.81303335
172Acanthosis nigricans (HP:0000956)1.81170463
173Gaze-evoked nystagmus (HP:0000640)1.80895556
174Increased serum lactate (HP:0002151)1.80116578
175Patellar aplasia (HP:0006443)1.79571575
176Aplasia/Hypoplasia of the tongue (HP:0010295)1.78919335
177Abnormal respiratory motile cilium morphology (HP:0005938)1.78451538
178Abnormal respiratory epithelium morphology (HP:0012253)1.78451538
179Hemiparesis (HP:0001269)1.78096856
180Mesangial abnormality (HP:0001966)1.77746666
181Clumsiness (HP:0002312)1.77428692
182Disproportionate short-trunk short stature (HP:0003521)1.76867760
183Azoospermia (HP:0000027)1.76804480
184Mixed hearing impairment (HP:0000410)1.76180078
185Lower limb amyotrophy (HP:0007210)1.75911643
186Abnormal gallbladder morphology (HP:0012437)1.75250451
187Aplasia/Hypoplasia of the patella (HP:0006498)1.74828003
188Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74000214
189Absent speech (HP:0001344)1.73921826
190Polyuria (HP:0000103)1.73579722
191Pheochromocytoma (HP:0002666)1.73483697
192Anophthalmia (HP:0000528)1.73093943
193Increased hepatocellular lipid droplets (HP:0006565)1.72754594
194Intestinal atresia (HP:0011100)1.72262651
195Hypoplastic left heart (HP:0004383)1.68906488
196Hypohidrosis (HP:0000966)1.68566885
197Broad ribs (HP:0000885)1.67941002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK27.52436641
2CAMK1D7.29203539
3CAMK1G5.49131666
4FRK4.16311866
5ADRBK23.98974075
6CAMKK13.16620553
7PBK3.08569576
8NME12.58332141
9MAP4K22.57126145
10ZAK2.55969593
11TLK12.40454449
12FGFR22.24195700
13PNCK2.12962524
14WNK42.11621579
15EPHA32.10658326
16MAP3K42.07195471
17RIPK42.05112218
18ERBB41.98751556
19FGR1.81047131
20NUAK11.77973810
21CAMK41.75532338
22TAOK31.65092838
23GRK51.62552027
24ACVR1B1.53411565
25GRK71.46277223
26PDK21.35657818
27MET1.31307254
28CAMK11.24335642
29FES1.19605055
30CSNK1G21.19335877
31CSNK1G11.14748047
32OXSR11.14542210
33EPHB21.14309246
34MOS1.14041603
35TBK11.11681314
36CASK1.11118020
37CSNK1G31.08297461
38TGFBR21.04231144
39DAPK21.02783907
40BCKDK0.99685264
41SIK20.94305052
42TIE10.94147664
43MAP3K90.94128914
44LRRK20.93725777
45RPS6KA40.93603260
46LIMK10.93422376
47NTRK20.91071775
48EPHA40.89956135
49ADRBK10.89202829
50MAPK150.89120189
51CSNK1A1L0.86286573
52PIM20.85536604
53VRK10.85286754
54NTRK30.85041524
55VRK20.81053807
56MARK10.80821834
57IRAK10.80037723
58BMPR20.80026488
59STK390.78936137
60PASK0.76543470
61PKN10.74517896
62BCR0.73432966
63SIK30.73273666
64MAP2K60.72444028
65PRKCQ0.70551481
66BMPR1B0.70483542
67INSRR0.70398346
68SIK10.68893306
69MKNK20.67067714
70TAF10.66225346
71CDK50.64794063
72TRIM280.62891231
73PRKCE0.62882595
74CAMK2B0.62280156
75STK160.60746396
76BLK0.59955805
77PAK60.59821725
78RIPK10.59170173
79TGFBR10.58229676
80MAP2K70.56619652
81PIK3CA0.55711914
82PRKCI0.53511777
83MAPKAPK50.50408498
84MST1R0.50038550
85WNK10.48747287
86UHMK10.46923330
87PTK2B0.46669659
88JAK30.44829057
89AKT30.44423767
90MAP2K40.43423601
91CSNK1A10.42876655
92CAMK2A0.42157802
93RPS6KA50.42068707
94TXK0.41173072
95CSNK1D0.39261919
96PLK20.38871225
97TNIK0.38044725
98FER0.35339113
99ERBB20.34911427
100FYN0.34400460
101MAPK120.33404251
102CHUK0.33364006
103PRKAA10.33074120
104MKNK10.31411200
105ARAF0.31377701
106MAPK130.30332576
107DYRK30.30116246
108KSR10.30043462
109FGFR10.29938974
110SGK2230.29546393
111SGK4940.29546393
112PAK30.29200461
113PRKCA0.29121796
114RAF10.28942073
115CDK30.28837700
116MAP3K60.28699568
117DYRK20.28522360
118PLK10.28082314
119CAMK2G0.27914595
120DYRK1A0.27813699
121EIF2AK30.27639055
122FLT30.27571888
123PINK10.27510209
124CAMK2D0.27479556
125IKBKB0.27467468
126TYRO30.26528548
127PLK30.25833372
128STK110.25601041
129PRKCG0.24981314
130PRKCH0.24151180
131ICK0.23703246
132KSR20.23244767
133TTN0.22308329
134MINK10.21810104
135MUSK0.21011236
136GRK10.18466873
137PRKACG0.18021589
138RPS6KA20.17576899
139PRKCZ0.16621364
140EPHA20.16586880
141SYK0.16429445
142PRKACA0.15919578
143PDK10.15108246
144EPHB10.14838082
145STK100.14561985
146PAK20.14542376
147PHKG10.14293446
148PHKG20.14293446
149SRC0.14191567
150WNK30.14180017
151PRKCB0.14108928
152SGK20.13825816
153IKBKE0.12463146

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.17604240
2Nicotine addiction_Homo sapiens_hsa050333.24791724
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.15466478
4Linoleic acid metabolism_Homo sapiens_hsa005912.87289061
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.81721795
6Collecting duct acid secretion_Homo sapiens_hsa049662.64801189
7Selenocompound metabolism_Homo sapiens_hsa004502.60133912
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.39432705
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.30603606
10Oxidative phosphorylation_Homo sapiens_hsa001902.26805890
11Synaptic vesicle cycle_Homo sapiens_hsa047212.04464909
12Tryptophan metabolism_Homo sapiens_hsa003801.98989044
13Nitrogen metabolism_Homo sapiens_hsa009101.96054244
14GABAergic synapse_Homo sapiens_hsa047271.90881763
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.89942681
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82094408
17Basal transcription factors_Homo sapiens_hsa030221.76017913
18Caffeine metabolism_Homo sapiens_hsa002321.74775065
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71324100
20Protein export_Homo sapiens_hsa030601.70332425
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69179966
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67848218
23Butanoate metabolism_Homo sapiens_hsa006501.62949917
24Cardiac muscle contraction_Homo sapiens_hsa042601.62263462
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56283581
26Circadian entrainment_Homo sapiens_hsa047131.54083054
27Cocaine addiction_Homo sapiens_hsa050301.52467263
28Glutamatergic synapse_Homo sapiens_hsa047241.51513889
29Amphetamine addiction_Homo sapiens_hsa050311.46956358
30One carbon pool by folate_Homo sapiens_hsa006701.45591800
31RNA polymerase_Homo sapiens_hsa030201.43566221
32Dopaminergic synapse_Homo sapiens_hsa047281.41913675
33Alzheimers disease_Homo sapiens_hsa050101.41717587
34beta-Alanine metabolism_Homo sapiens_hsa004101.41575211
35Salivary secretion_Homo sapiens_hsa049701.40929706
36Taste transduction_Homo sapiens_hsa047421.38167887
37Calcium signaling pathway_Homo sapiens_hsa040201.30639660
38Type I diabetes mellitus_Homo sapiens_hsa049401.29834089
39Morphine addiction_Homo sapiens_hsa050321.24963262
40Serotonergic synapse_Homo sapiens_hsa047261.23289252
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21660456
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.19731942
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19390756
44Renin secretion_Homo sapiens_hsa049241.19101992
45Cholinergic synapse_Homo sapiens_hsa047251.17356149
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17347453
47Axon guidance_Homo sapiens_hsa043601.15378508
48Long-term depression_Homo sapiens_hsa047301.14419331
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13730678
50Peroxisome_Homo sapiens_hsa041461.11343527
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09866336
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.09852521
53Parkinsons disease_Homo sapiens_hsa050121.09718434
54Phototransduction_Homo sapiens_hsa047441.07547348
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.06870997
56Arachidonic acid metabolism_Homo sapiens_hsa005901.05799236
57Phenylalanine metabolism_Homo sapiens_hsa003601.05614064
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05581212
59Rheumatoid arthritis_Homo sapiens_hsa053231.03971471
60Vitamin B6 metabolism_Homo sapiens_hsa007501.03945295
61Vibrio cholerae infection_Homo sapiens_hsa051101.03693119
62Pancreatic secretion_Homo sapiens_hsa049721.03402453
63Phagosome_Homo sapiens_hsa041451.02876578
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00869896
65Long-term potentiation_Homo sapiens_hsa047201.00832723
66Amoebiasis_Homo sapiens_hsa051461.00804525
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.00256557
68Insulin secretion_Homo sapiens_hsa049110.94866565
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.93943221
70Fat digestion and absorption_Homo sapiens_hsa049750.93873954
71Fanconi anemia pathway_Homo sapiens_hsa034600.93740723
72Retinol metabolism_Homo sapiens_hsa008300.93120045
73Ether lipid metabolism_Homo sapiens_hsa005650.93016163
74ABC transporters_Homo sapiens_hsa020100.91562102
75Oxytocin signaling pathway_Homo sapiens_hsa049210.90571832
76Prion diseases_Homo sapiens_hsa050200.90537395
77Ribosome_Homo sapiens_hsa030100.89253290
78Homologous recombination_Homo sapiens_hsa034400.88830847
79RNA degradation_Homo sapiens_hsa030180.87724676
80cAMP signaling pathway_Homo sapiens_hsa040240.86591958
81Pyruvate metabolism_Homo sapiens_hsa006200.86410010
82Huntingtons disease_Homo sapiens_hsa050160.85194235
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84009645
84Dilated cardiomyopathy_Homo sapiens_hsa054140.81227488
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80830160
86Ovarian steroidogenesis_Homo sapiens_hsa049130.80658906
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80254654
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79738702
89Complement and coagulation cascades_Homo sapiens_hsa046100.79148693
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76427533
91Gastric acid secretion_Homo sapiens_hsa049710.76259940
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73664188
93Olfactory transduction_Homo sapiens_hsa047400.73610188
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73029660
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.72476020
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71303420
97Propanoate metabolism_Homo sapiens_hsa006400.70915441
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70578702
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69279823
100Fatty acid biosynthesis_Homo sapiens_hsa000610.69154428
101Metabolic pathways_Homo sapiens_hsa011000.67854413
102Protein digestion and absorption_Homo sapiens_hsa049740.67667788
103Melanogenesis_Homo sapiens_hsa049160.67011425
104Sphingolipid metabolism_Homo sapiens_hsa006000.61596697
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61038186
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60496815
107Chemokine signaling pathway_Homo sapiens_hsa040620.59925658
108Pertussis_Homo sapiens_hsa051330.59753920
109Regulation of autophagy_Homo sapiens_hsa041400.59304434
110Salmonella infection_Homo sapiens_hsa051320.58481676
111Type II diabetes mellitus_Homo sapiens_hsa049300.57969848
112Ras signaling pathway_Homo sapiens_hsa040140.57229205
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56988120
114Vitamin digestion and absorption_Homo sapiens_hsa049770.56158276
115Chemical carcinogenesis_Homo sapiens_hsa052040.54644458
116Steroid biosynthesis_Homo sapiens_hsa001000.54510638
117Histidine metabolism_Homo sapiens_hsa003400.54175910
118ECM-receptor interaction_Homo sapiens_hsa045120.53984592
119Staphylococcus aureus infection_Homo sapiens_hsa051500.52117347
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52047367
121Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51602739
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.49287266
123Fatty acid elongation_Homo sapiens_hsa000620.47431441
124Hedgehog signaling pathway_Homo sapiens_hsa043400.47382429
125Rap1 signaling pathway_Homo sapiens_hsa040150.47185854
126Sulfur metabolism_Homo sapiens_hsa009200.46766405
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46573191
128Glioma_Homo sapiens_hsa052140.46404227
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45007204
130MAPK signaling pathway_Homo sapiens_hsa040100.44964176
131Purine metabolism_Homo sapiens_hsa002300.44681608
132African trypanosomiasis_Homo sapiens_hsa051430.44288163
133Mineral absorption_Homo sapiens_hsa049780.44019500
134Glycerolipid metabolism_Homo sapiens_hsa005610.43207570
135GnRH signaling pathway_Homo sapiens_hsa049120.42593450
136Arginine biosynthesis_Homo sapiens_hsa002200.42398825
137Bile secretion_Homo sapiens_hsa049760.40558517
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40312532
139Fatty acid degradation_Homo sapiens_hsa000710.40218263
140Arginine and proline metabolism_Homo sapiens_hsa003300.38899572
141Alcoholism_Homo sapiens_hsa050340.37393124
142Thyroid hormone synthesis_Homo sapiens_hsa049180.36671533
143Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36585405
144Sulfur relay system_Homo sapiens_hsa041220.36486003
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.36170934
146Basal cell carcinoma_Homo sapiens_hsa052170.36145975
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34956719
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34165575
149Circadian rhythm_Homo sapiens_hsa047100.33945995
150Fatty acid metabolism_Homo sapiens_hsa012120.33815373
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.33121276
152Pyrimidine metabolism_Homo sapiens_hsa002400.33118416
153Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32613194

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