GFRA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.65785503
2synaptic vesicle exocytosis (GO:0016079)5.53888212
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.28821506
4vocalization behavior (GO:0071625)5.26508276
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17493607
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11720707
7regulation of glutamate receptor signaling pathway (GO:1900449)5.05576630
8glutamate secretion (GO:0014047)4.99143443
9locomotory exploration behavior (GO:0035641)4.87519703
10protein localization to synapse (GO:0035418)4.82135169
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.81498499
12glutamate receptor signaling pathway (GO:0007215)4.78887168
13regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.72161471
14neuron cell-cell adhesion (GO:0007158)4.67044130
15regulation of synaptic vesicle exocytosis (GO:2000300)4.58866744
16synaptic vesicle maturation (GO:0016188)4.57480139
17neuronal action potential propagation (GO:0019227)4.56926700
18exploration behavior (GO:0035640)4.34792333
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32222650
20neuron-neuron synaptic transmission (GO:0007270)4.26173070
21regulation of neuronal synaptic plasticity (GO:0048168)4.24573128
22regulation of synaptic vesicle transport (GO:1902803)4.21158807
23synaptic transmission, glutamatergic (GO:0035249)4.19188930
24gamma-aminobutyric acid signaling pathway (GO:0007214)4.16487903
25neuron recognition (GO:0008038)4.08677802
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.06464656
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.02751315
28neurotransmitter secretion (GO:0007269)3.97613401
29synaptic vesicle docking involved in exocytosis (GO:0016081)3.87141839
30regulation of postsynaptic membrane potential (GO:0060078)3.85584744
31response to histamine (GO:0034776)3.82498281
32regulation of glutamate secretion (GO:0014048)3.81079100
33long-term memory (GO:0007616)3.80071917
34negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79492597
35behavioral fear response (GO:0001662)3.79171239
36behavioral defense response (GO:0002209)3.79171239
37synaptic vesicle endocytosis (GO:0048488)3.77684231
38long-term synaptic potentiation (GO:0060291)3.75568911
39neurotransmitter-gated ion channel clustering (GO:0072578)3.71783609
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.67676377
41regulation of synaptic plasticity (GO:0048167)3.67342624
42positive regulation of synapse maturation (GO:0090129)3.62059982
43regulation of synapse structural plasticity (GO:0051823)3.59807966
44fear response (GO:0042596)3.57873845
45axonal fasciculation (GO:0007413)3.54731837
46regulation of dendritic spine morphogenesis (GO:0061001)3.54251634
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.53959592
48regulation of vesicle fusion (GO:0031338)3.53711525
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.51154594
50dendritic spine morphogenesis (GO:0060997)3.49088130
51transmission of nerve impulse (GO:0019226)3.48968102
52positive regulation of membrane potential (GO:0045838)3.48540074
53proline transport (GO:0015824)3.43849451
54presynaptic membrane assembly (GO:0097105)3.41766528
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40889906
56layer formation in cerebral cortex (GO:0021819)3.40411458
57neurotransmitter transport (GO:0006836)3.39393498
58behavioral response to cocaine (GO:0048148)3.38473782
59negative regulation of amino acid transport (GO:0051956)3.35918235
60regulation of neurotransmitter secretion (GO:0046928)3.30404660
61cellular potassium ion homeostasis (GO:0030007)3.29551650
62membrane depolarization (GO:0051899)3.28718164
63positive regulation of neurotransmitter secretion (GO:0001956)3.25917697
64detection of calcium ion (GO:0005513)3.24311333
65activation of protein kinase A activity (GO:0034199)3.19043962
66presynaptic membrane organization (GO:0097090)3.18551271
67postsynaptic membrane organization (GO:0001941)3.16801132
68regulation of neurotransmitter levels (GO:0001505)3.12898103
69learning (GO:0007612)3.11024121
70membrane depolarization during action potential (GO:0086010)3.10387204
71regulation of dendritic spine development (GO:0060998)3.08778361
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06815418
73gamma-aminobutyric acid transport (GO:0015812)3.06408006
74synaptic transmission, dopaminergic (GO:0001963)3.04954693
75negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04205931
76regulation of neurotransmitter transport (GO:0051588)3.04014255
77regulation of synaptic transmission (GO:0050804)3.03744604
78positive regulation of neurotransmitter transport (GO:0051590)3.03587290
79synaptic transmission (GO:0007268)3.03528761
80positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03211515
81striatum development (GO:0021756)3.02870292
82positive regulation of synaptic transmission, GABAergic (GO:0032230)3.01695626
83neuromuscular process controlling posture (GO:0050884)3.01427006
84mating behavior (GO:0007617)3.00559498
85positive regulation of dendritic spine morphogenesis (GO:0061003)2.97858301
86membrane hyperpolarization (GO:0060081)2.97690566
87innervation (GO:0060384)2.96876906
88vesicle transport along microtubule (GO:0047496)2.95356051
89regulation of protein kinase A signaling (GO:0010738)2.93396933
90dendritic spine organization (GO:0097061)2.93060148
91positive regulation of dendritic spine development (GO:0060999)2.92992945
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92473731
93intraspecies interaction between organisms (GO:0051703)2.92125430
94social behavior (GO:0035176)2.92125430
95startle response (GO:0001964)2.92053070
96positive regulation of synaptic transmission (GO:0050806)2.89727285
97long term synaptic depression (GO:0060292)2.88888795
98cerebellar Purkinje cell differentiation (GO:0021702)2.87845580
99synaptic vesicle transport (GO:0048489)2.86961989
100establishment of synaptic vesicle localization (GO:0097480)2.86961989

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.64333719
2GBX2_23144817_ChIP-Seq_PC3_Human3.94620987
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.21501644
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14440256
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12032523
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74696274
7REST_21632747_ChIP-Seq_MESCs_Mouse2.71499316
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71318136
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71318136
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68977097
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59884351
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.59206123
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50606080
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49659277
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47669114
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.44683880
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.44620958
18TAF15_26573619_Chip-Seq_HEK293_Human2.38611731
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17959588
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.15840104
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15507187
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.13496417
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.13227269
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12164455
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09265096
26DROSHA_22980978_ChIP-Seq_HELA_Human2.07911139
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99577338
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89520557
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85706336
30SMAD4_21799915_ChIP-Seq_A2780_Human1.82431343
31AR_21572438_ChIP-Seq_LNCaP_Human1.76867842
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74957164
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72339231
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70673914
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67668106
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66469997
37ZNF274_21170338_ChIP-Seq_K562_Hela1.64567565
38P300_19829295_ChIP-Seq_ESCs_Human1.63700261
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57764713
40VDR_22108803_ChIP-Seq_LS180_Human1.57201850
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56942995
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46937263
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46362303
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43745090
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.42214748
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40226180
47FUS_26573619_Chip-Seq_HEK293_Human1.39910202
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.38574647
49AR_25329375_ChIP-Seq_VCAP_Human1.38290305
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.38054283
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37259737
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.36866714
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33722284
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.29343949
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29309200
56RNF2_27304074_Chip-Seq_NSC_Mouse1.26640438
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.25554311
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.25299305
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23749654
60STAT3_23295773_ChIP-Seq_U87_Human1.22940030
61TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21151854
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20778316
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20242397
64IGF1R_20145208_ChIP-Seq_DFB_Human1.19631763
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19156221
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17218780
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14747914
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11892748
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11029832
70TCF4_23295773_ChIP-Seq_U87_Human1.10230890
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09849487
72JUN_21703547_ChIP-Seq_K562_Human1.08900238
73AR_19668381_ChIP-Seq_PC3_Human1.08818855
74* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07410631
75RUNX2_22187159_ChIP-Seq_PCA_Human1.07129453
76BCAT_22108803_ChIP-Seq_LS180_Human1.05764778
77TP53_16413492_ChIP-PET_HCT116_Human1.01911807
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.01086943
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00265721
80SMAD_19615063_ChIP-ChIP_OVARY_Human0.99037333
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97428534
82YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97315842
83* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96995465
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96568741
85RING1B_27294783_Chip-Seq_NPCs_Mouse0.96457243
86TP53_18474530_ChIP-ChIP_U2OS_Human0.96267708
87* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95933306
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95320639
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95320639
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95319254
91ER_23166858_ChIP-Seq_MCF-7_Human0.94703490
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93651346
93AHR_22903824_ChIP-Seq_MCF-7_Human0.90987556
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90623637
95KDM2B_26808549_Chip-Seq_REH_Human0.90377274
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89507425
97CBP_20019798_ChIP-Seq_JUKART_Human0.89210209
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89210209
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.89203749
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88562930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.20430982
2MP0003880_abnormal_central_pattern5.78603884
3MP0003635_abnormal_synaptic_transmissio4.16137476
4MP0009745_abnormal_behavioral_response3.59988770
5MP0004270_analgesia3.46506676
6MP0002063_abnormal_learning/memory/cond3.39857562
7MP0001968_abnormal_touch/_nociception3.24085760
8MP0002064_seizures3.19968712
9MP0002572_abnormal_emotion/affect_behav2.91054802
10MP0009046_muscle_twitch2.79628554
11MP0002736_abnormal_nociception_after2.63670579
12MP0002272_abnormal_nervous_system2.62528303
13MP0001501_abnormal_sleep_pattern2.56363831
14MP0002822_catalepsy2.50231936
15MP0002735_abnormal_chemical_nociception2.46709954
16MP0002734_abnormal_mechanical_nocicepti2.44978511
17MP0001440_abnormal_grooming_behavior2.43796516
18MP0001486_abnormal_startle_reflex2.39434525
19MP0005423_abnormal_somatic_nervous2.20242091
20MP0006276_abnormal_autonomic_nervous2.17358215
21MP0002733_abnormal_thermal_nociception2.02418677
22MP0003329_amyloid_beta_deposits2.01355717
23MP0002067_abnormal_sensory_capabilities2.01201204
24MP0001970_abnormal_pain_threshold1.96582071
25MP0001529_abnormal_vocalization1.95770823
26MP0002184_abnormal_innervation1.84201990
27MP0002837_dystrophic_cardiac_calcinosis1.78010843
28MP0005386_behavior/neurological_phenoty1.75540309
29MP0004924_abnormal_behavior1.75540309
30MP0000778_abnormal_nervous_system1.71051723
31MP0003787_abnormal_imprinting1.66075668
32MP0001905_abnormal_dopamine_level1.64925811
33MP0002557_abnormal_social/conspecific_i1.63739221
34MP0003879_abnormal_hair_cell1.58340065
35MP0009780_abnormal_chondrocyte_physiolo1.58043181
36MP0001984_abnormal_olfaction1.57830186
37MP0008569_lethality_at_weaning1.56314677
38MP0003122_maternal_imprinting1.51808863
39MP0005646_abnormal_pituitary_gland1.50335111
40MP0002909_abnormal_adrenal_gland1.49411544
41MP0004811_abnormal_neuron_physiology1.47826222
42MP0000955_abnormal_spinal_cord1.36855396
43MP0002066_abnormal_motor_capabilities/c1.36805190
44MP0004858_abnormal_nervous_system1.34910611
45MP0002882_abnormal_neuron_morphology1.31825609
46MP0001188_hyperpigmentation1.31610038
47MP0001502_abnormal_circadian_rhythm1.29907180
48MP0000751_myopathy1.28259729
49MP0004142_abnormal_muscle_tone1.27680379
50MP0010386_abnormal_urinary_bladder1.21816073
51MP0004145_abnormal_muscle_electrophysio1.21270428
52MP0003633_abnormal_nervous_system1.12273556
53MP0005645_abnormal_hypothalamus_physiol1.01334042
54MP0002152_abnormal_brain_morphology1.01055863
55MP0003631_nervous_system_phenotype0.98346833
56MP0003123_paternal_imprinting0.96580691
57MP0000013_abnormal_adipose_tissue0.96550495
58MP0005535_abnormal_body_temperature0.95229353
59MP0005551_abnormal_eye_electrophysiolog0.94152963
60MP0000604_amyloidosis0.90896029
61MP0008872_abnormal_physiological_respon0.90703444
62MP0004085_abnormal_heartbeat0.90589408
63MP0002069_abnormal_eating/drinking_beha0.89532889
64MP0008874_decreased_physiological_sensi0.89289450
65MP0004215_abnormal_myocardial_fiber0.88989672
66MP0004885_abnormal_endolymph0.88173247
67MP0002229_neurodegeneration0.86130212
68MP0001963_abnormal_hearing_physiology0.85401503
69MP0004742_abnormal_vestibular_system0.84423640
70MP0004484_altered_response_of0.83317548
71MP0005499_abnormal_olfactory_system0.78910664
72MP0005394_taste/olfaction_phenotype0.78910664
73MP0002752_abnormal_somatic_nervous0.76038268
74MP0004510_myositis0.75274670
75MP0001664_abnormal_digestion0.74940866
76MP0005409_darkened_coat_color0.74898997
77MP0005410_abnormal_fertilization0.74394694
78MP0008877_abnormal_DNA_methylation0.73862008
79MP0000631_abnormal_neuroendocrine_gland0.69598791
80MP0001177_atelectasis0.68633232
81MP0004233_abnormal_muscle_weight0.66747799
82MP0003632_abnormal_nervous_system0.65547543
83MP0008961_abnormal_basal_metabolism0.64087647
84MP0010234_abnormal_vibrissa_follicle0.63906755
85MP0003121_genomic_imprinting0.63835583
86MP0003075_altered_response_to0.63430405
87MP0003283_abnormal_digestive_organ0.61673128
88MP0001485_abnormal_pinna_reflex0.61308732
89MP0003646_muscle_fatigue0.61056269
90MP0001765_abnormal_ion_homeostasis0.58381964
91MP0000026_abnormal_inner_ear0.57446965
92MP0002090_abnormal_vision0.56632223
93MP0003634_abnormal_glial_cell0.56592622
94MP0001943_abnormal_respiration0.54724753
95MP0005623_abnormal_meninges_morphology0.53615665
96MP0005187_abnormal_penis_morphology0.53437561
97MP0003137_abnormal_impulse_conducting0.53108669
98MP0002638_abnormal_pupillary_reflex0.50690379
99MP0005620_abnormal_muscle_contractility0.49101601
100MP0004036_abnormal_muscle_relaxation0.48268878

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.63388882
2Focal seizures (HP:0007359)6.20163038
3Myokymia (HP:0002411)6.00363141
4Visual hallucinations (HP:0002367)5.76097089
5Atonic seizures (HP:0010819)5.44500130
6Epileptic encephalopathy (HP:0200134)5.16237240
7Absence seizures (HP:0002121)4.91792590
8Febrile seizures (HP:0002373)4.73157878
9Dialeptic seizures (HP:0011146)4.49770558
10Generalized tonic-clonic seizures (HP:0002069)4.21927138
11Hyperventilation (HP:0002883)4.04544147
12Progressive cerebellar ataxia (HP:0002073)3.89948923
13Broad-based gait (HP:0002136)3.52845111
14Amblyopia (HP:0000646)3.52503691
15Poor eye contact (HP:0000817)3.18541794
16Supranuclear gaze palsy (HP:0000605)3.16426323
17Cerebral inclusion bodies (HP:0100314)3.16191827
18Impaired vibration sensation in the lower limbs (HP:0002166)3.13098633
19Anxiety (HP:0000739)3.00284618
20Action tremor (HP:0002345)2.99377274
21Truncal ataxia (HP:0002078)2.95574073
22Gaze-evoked nystagmus (HP:0000640)2.94672794
23Dysmetria (HP:0001310)2.89413242
24Dysdiadochokinesis (HP:0002075)2.86401066
25Depression (HP:0000716)2.84937850
26Abnormal social behavior (HP:0012433)2.82846609
27Impaired social interactions (HP:0000735)2.82846609
28Excessive salivation (HP:0003781)2.74714517
29Drooling (HP:0002307)2.74714517
30Epileptiform EEG discharges (HP:0011182)2.72948819
31Abnormal eating behavior (HP:0100738)2.72466846
32Neurofibrillary tangles (HP:0002185)2.66642943
33Progressive inability to walk (HP:0002505)2.61089981
34Urinary bladder sphincter dysfunction (HP:0002839)2.56265601
35Absent speech (HP:0001344)2.55822340
36EEG with generalized epileptiform discharges (HP:0011198)2.51903696
37Delusions (HP:0000746)2.48679048
38Abnormality of the lower motor neuron (HP:0002366)2.47531628
39Inability to walk (HP:0002540)2.46232389
40Ankle clonus (HP:0011448)2.46223313
41Insidious onset (HP:0003587)2.44999062
42Termporal pattern (HP:0011008)2.44999062
43Scanning speech (HP:0002168)2.41956187
44Urinary urgency (HP:0000012)2.40161993
45Hemiparesis (HP:0001269)2.37765974
46Impaired smooth pursuit (HP:0007772)2.37335493
47Gait imbalance (HP:0002141)2.29626913
48Hypsarrhythmia (HP:0002521)2.27407076
49Fetal akinesia sequence (HP:0001989)2.24860474
50Abnormality of binocular vision (HP:0011514)2.23291649
51Diplopia (HP:0000651)2.23291649
52Stereotypic behavior (HP:0000733)2.20338329
53Mutism (HP:0002300)2.19592298
54Absent/shortened dynein arms (HP:0200106)2.18236193
55Dynein arm defect of respiratory motile cilia (HP:0012255)2.18236193
56Bradykinesia (HP:0002067)2.17882007
57Polyphagia (HP:0002591)2.16257583
58Generalized myoclonic seizures (HP:0002123)2.15418018
59Postural instability (HP:0002172)2.14503610
60Pheochromocytoma (HP:0002666)2.12665754
61Spastic gait (HP:0002064)2.12648748
62Status epilepticus (HP:0002133)2.09956029
63Acute necrotizing encephalopathy (HP:0006965)2.08440744
64Papilledema (HP:0001085)2.04357125
65Abnormality of ocular smooth pursuit (HP:0000617)2.03245873
66Congenital primary aphakia (HP:0007707)2.02513982
67Genetic anticipation (HP:0003743)2.01944324
68Protruding tongue (HP:0010808)2.01447583
69Psychosis (HP:0000709)1.99729654
70Abnormal ciliary motility (HP:0012262)1.99370687
71Medial flaring of the eyebrow (HP:0010747)1.97256690
72Progressive macrocephaly (HP:0004481)1.96626563
73Abnormality of the corticospinal tract (HP:0002492)1.95429860
74Impaired vibratory sensation (HP:0002495)1.95287738
75Abnormal mitochondria in muscle tissue (HP:0008316)1.95120133
76Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.92096491
77Retinal dysplasia (HP:0007973)1.91962456
78Rapidly progressive (HP:0003678)1.90049579
79Thickened helices (HP:0000391)1.89445636
80Blue irides (HP:0000635)1.89277148
81Torticollis (HP:0000473)1.86477421
82Abnormality of salivation (HP:0100755)1.86203458
83Limb dystonia (HP:0002451)1.85942384
84Gait ataxia (HP:0002066)1.85821493
85Annular pancreas (HP:0001734)1.85295689
86Neuroendocrine neoplasm (HP:0100634)1.85151604
87Focal dystonia (HP:0004373)1.85011471
88Incomplete penetrance (HP:0003829)1.83745491
89Nephrogenic diabetes insipidus (HP:0009806)1.83212563
90Abnormal respiratory motile cilium physiology (HP:0012261)1.81812885
91Abnormal respiratory epithelium morphology (HP:0012253)1.81598853
92Abnormal respiratory motile cilium morphology (HP:0005938)1.81598853
93Lower limb muscle weakness (HP:0007340)1.80552610
94Dysmetric saccades (HP:0000641)1.79140073
95Hyperthyroidism (HP:0000836)1.78298409
96Lower limb asymmetry (HP:0100559)1.77197249
97Hypoventilation (HP:0002791)1.74900051
98Specific learning disability (HP:0001328)1.74159264
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.73383273
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.73383273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.00721572
2EPHA44.96565852
3MAP3K93.75412344
4MAP3K43.09924531
5RIPK42.95371110
6MAP3K122.81931391
7MAP2K72.73565278
8MINK12.53903840
9ARAF2.25167391
10PNCK2.24354666
11CASK2.23829185
12KSR22.21913051
13DAPK22.09476847
14MAP2K42.08682815
15PLK21.96849965
16MARK11.93603498
17KSR11.87760554
18MAP3K131.80171310
19PAK61.66856675
20DAPK11.63650846
21GRK51.61299994
22NTRK11.54476862
23NTRK21.53975144
24SIK21.53365016
25PTK2B1.49587217
26PRKD31.46450006
27NME11.43745454
28BMPR21.42753023
29CDK51.38591992
30TNIK1.34407397
31FES1.32783953
32CDK191.26826266
33MAPK131.24366416
34PRPF4B1.19347840
35CAMKK11.18490272
36PRKCG1.17715395
37RAF11.17229716
38CAMK2A1.15907966
39STK381.09714704
40LATS21.07362178
41FGR0.92536983
42CAMK2B0.89569915
43MAP3K20.89245921
44CAMKK20.86585130
45UHMK10.82859000
46CDK180.80791000
47CDK140.80026934
48CCNB10.79401126
49CAMK10.78977574
50CDK150.76374655
51GRK70.75829373
52FER0.74951654
53BRAF0.74252823
54TYRO30.73579718
55DYRK1A0.71025505
56OXSR10.65274366
57CDK11A0.65242771
58SGK10.62230104
59MAP2K10.61629033
60MAP3K10.60689467
61SGK2230.60016507
62SGK4940.60016507
63PRKCE0.59007194
64MAP3K60.58513000
65PAK30.56836959
66MOS0.56751353
67CAMK2D0.55877269
68TNK20.55775294
69RET0.55375428
70SIK30.54131585
71PINK10.54000505
72STK110.53481496
73PHKG10.52203427
74PHKG20.52203427
75PDK40.51449975
76PDK30.51449975
77GRK60.50819778
78CAMK2G0.49457562
79LMTK20.48083657
80SGK20.47376057
81PDPK10.45620964
82MUSK0.45033190
83PDK10.43730908
84WNK30.43149991
85DAPK30.40218009
86ROCK20.39613248
87PRKCH0.39317773
88CSNK1G20.39197469
89ADRBK10.38244543
90PRKCZ0.38215265
91CAMK1G0.36047651
92MARK20.35867621
93RPS6KA30.34902677
94ADRBK20.34762562
95BCR0.34135602
96PRKACA0.32980003
97MAPK120.32317508
98MAPK100.30089300
99FYN0.29650016
100TAOK10.28740767

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.09134310
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21939224
3Long-term potentiation_Homo sapiens_hsa047202.96526360
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.90486117
5Circadian entrainment_Homo sapiens_hsa047132.71413199
6Amphetamine addiction_Homo sapiens_hsa050312.63936963
7GABAergic synapse_Homo sapiens_hsa047272.63429296
8Olfactory transduction_Homo sapiens_hsa047402.59384783
9Glutamatergic synapse_Homo sapiens_hsa047242.58561947
10Morphine addiction_Homo sapiens_hsa050322.49695590
11Dopaminergic synapse_Homo sapiens_hsa047282.23230629
12Salivary secretion_Homo sapiens_hsa049702.20897609
13Collecting duct acid secretion_Homo sapiens_hsa049662.18302215
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.09148541
15Taste transduction_Homo sapiens_hsa047422.00141039
16Renin secretion_Homo sapiens_hsa049241.98317404
17Insulin secretion_Homo sapiens_hsa049111.87514588
18Serotonergic synapse_Homo sapiens_hsa047261.87220759
19Long-term depression_Homo sapiens_hsa047301.86341102
20Gastric acid secretion_Homo sapiens_hsa049711.82746396
21Cholinergic synapse_Homo sapiens_hsa047251.79884460
22Oxytocin signaling pathway_Homo sapiens_hsa049211.78926049
23Calcium signaling pathway_Homo sapiens_hsa040201.76220919
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74113735
25Oxidative phosphorylation_Homo sapiens_hsa001901.60284250
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60162821
27Cocaine addiction_Homo sapiens_hsa050301.59762306
28Cardiac muscle contraction_Homo sapiens_hsa042601.55134153
29GnRH signaling pathway_Homo sapiens_hsa049121.51656269
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.38588443
31Alzheimers disease_Homo sapiens_hsa050101.38041422
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32710412
33Gap junction_Homo sapiens_hsa045401.30975680
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30523300
35Vibrio cholerae infection_Homo sapiens_hsa051101.28747408
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21010595
37cAMP signaling pathway_Homo sapiens_hsa040241.20631498
38Parkinsons disease_Homo sapiens_hsa050121.18759123
39Estrogen signaling pathway_Homo sapiens_hsa049151.13261359
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09364006
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08806015
42Phototransduction_Homo sapiens_hsa047441.07261862
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04199244
44Melanogenesis_Homo sapiens_hsa049161.03597473
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.03376758
46Oocyte meiosis_Homo sapiens_hsa041141.01905055
47Axon guidance_Homo sapiens_hsa043600.99919259
48Glioma_Homo sapiens_hsa052140.97407190
49Huntingtons disease_Homo sapiens_hsa050160.90850978
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90555512
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88894044
52Type II diabetes mellitus_Homo sapiens_hsa049300.87525766
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84422401
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82706255
55ErbB signaling pathway_Homo sapiens_hsa040120.82160387
56Pancreatic secretion_Homo sapiens_hsa049720.78343827
57Dorso-ventral axis formation_Homo sapiens_hsa043200.77582078
58Dilated cardiomyopathy_Homo sapiens_hsa054140.72906407
59Thyroid hormone synthesis_Homo sapiens_hsa049180.71974249
60Glucagon signaling pathway_Homo sapiens_hsa049220.71321603
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.70274378
62VEGF signaling pathway_Homo sapiens_hsa043700.68838363
63Choline metabolism in cancer_Homo sapiens_hsa052310.62488035
64MAPK signaling pathway_Homo sapiens_hsa040100.60339717
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58740483
66African trypanosomiasis_Homo sapiens_hsa051430.55402147
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54971890
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52307756
69Ras signaling pathway_Homo sapiens_hsa040140.47549181
70Prion diseases_Homo sapiens_hsa050200.45351162
71Rheumatoid arthritis_Homo sapiens_hsa053230.44430896
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.43248457
73Rap1 signaling pathway_Homo sapiens_hsa040150.43013737
74Inositol phosphate metabolism_Homo sapiens_hsa005620.42884637
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.41762484
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41336357
77Alcoholism_Homo sapiens_hsa050340.41290086
78Wnt signaling pathway_Homo sapiens_hsa043100.36738188
79Type I diabetes mellitus_Homo sapiens_hsa049400.36610392
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36524915
81Circadian rhythm_Homo sapiens_hsa047100.35803529
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34995849
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34623303
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34486783
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32146959
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31590148
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30904008
88Ovarian steroidogenesis_Homo sapiens_hsa049130.28615277
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27263987
90Insulin signaling pathway_Homo sapiens_hsa049100.26004004
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22010641
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21996661
93Non-small cell lung cancer_Homo sapiens_hsa052230.21985581
94mTOR signaling pathway_Homo sapiens_hsa041500.21462405
95Renal cell carcinoma_Homo sapiens_hsa052110.20739255
96Endocytosis_Homo sapiens_hsa041440.19912899
97Bile secretion_Homo sapiens_hsa049760.19908647
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19704240
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19475715
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17754907

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