GET4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.13756568
2DNA strand elongation involved in DNA replication (GO:0006271)4.96053669
3viral transcription (GO:0019083)4.88280552
4negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.84472793
5translational termination (GO:0006415)4.78025685
6DNA replication initiation (GO:0006270)4.66635940
7maturation of SSU-rRNA (GO:0030490)4.64867940
8DNA strand elongation (GO:0022616)4.62292460
9telomere maintenance via semi-conservative replication (GO:0032201)4.55917762
10DNA unwinding involved in DNA replication (GO:0006268)4.54522881
11GDP-mannose metabolic process (GO:0019673)4.48035251
12translational elongation (GO:0006414)4.45691692
13formation of translation preinitiation complex (GO:0001731)4.39160994
14folic acid-containing compound biosynthetic process (GO:0009396)4.36750903
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.33957089
16negative regulation of DNA-templated transcription, elongation (GO:0032785)4.27537772
17translational initiation (GO:0006413)4.27022255
18ribosomal small subunit assembly (GO:0000028)4.23121489
19protein retention in ER lumen (GO:0006621)4.22464849
20protein targeting to ER (GO:0045047)4.22322217
21cotranslational protein targeting to membrane (GO:0006613)4.20826519
22establishment of protein localization to endoplasmic reticulum (GO:0072599)4.02608755
23DNA replication checkpoint (GO:0000076)4.01145349
24ribosomal small subunit biogenesis (GO:0042274)4.00914804
25protein localization to endoplasmic reticulum (GO:0070972)3.98290504
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.97661393
27maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.97135441
28ribosomal large subunit biogenesis (GO:0042273)3.95774690
29spliceosomal tri-snRNP complex assembly (GO:0000244)3.92965138
30negative regulation of cell size (GO:0045792)3.91383367
31modulation by virus of host process (GO:0019054)3.87147619
32proteasome assembly (GO:0043248)3.84133980
33DNA replication-dependent nucleosome assembly (GO:0006335)3.81619963
34DNA replication-dependent nucleosome organization (GO:0034723)3.81619963
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.78564795
36viral life cycle (GO:0019058)3.77493873
37cellular protein complex disassembly (GO:0043624)3.76556201
38telomere maintenance via recombination (GO:0000722)3.75146968
39ribonucleoprotein complex biogenesis (GO:0022613)3.73292642
40nucleobase biosynthetic process (GO:0046112)3.68898740
41ribosome biogenesis (GO:0042254)3.68117263
42intracellular estrogen receptor signaling pathway (GO:0030520)3.67820213
43apoptotic process involved in morphogenesis (GO:0060561)3.62466235
44spliceosomal snRNP assembly (GO:0000387)3.62375390
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.61725064
46mitotic nuclear envelope disassembly (GO:0007077)3.57267887
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55945749
48pentose metabolic process (GO:0019321)3.55699873
49protein maturation by protein folding (GO:0022417)3.54842967
50folic acid metabolic process (GO:0046655)3.48855290
51translation (GO:0006412)3.47946803
52mitotic recombination (GO:0006312)3.46875911
53ribosome assembly (GO:0042255)3.46274274
54protein complex disassembly (GO:0043241)3.45270015
55activation of MAPKKK activity (GO:0000185)3.43857604
56telomere maintenance via telomere lengthening (GO:0010833)3.43171672
57pteridine-containing compound biosynthetic process (GO:0042559)3.42849631
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.42365433
59pseudouridine synthesis (GO:0001522)3.41998235
60proline metabolic process (GO:0006560)3.40085967
61nucleotide-excision repair, DNA gap filling (GO:0006297)3.36311834
62negative regulation of erythrocyte differentiation (GO:0045647)3.35102499
63purine nucleobase biosynthetic process (GO:0009113)3.33014662
64glucose catabolic process (GO:0006007)3.32425769
65membrane disassembly (GO:0030397)3.31491878
66nuclear envelope disassembly (GO:0051081)3.31491878
67modulation by symbiont of host cellular process (GO:0044068)3.30084573
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30063000
69negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.29120745
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29007062
71macromolecular complex disassembly (GO:0032984)3.28245007
72mannose metabolic process (GO:0006013)3.28031891
73protein localization to kinetochore (GO:0034501)3.27046092
74IMP biosynthetic process (GO:0006188)3.23248728
75negative regulation of RNA splicing (GO:0033119)3.23017911
76snRNA metabolic process (GO:0016073)3.22637993
77rRNA processing (GO:0006364)3.21708814
78NADH metabolic process (GO:0006734)3.21238715
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16247360
80histone H4 deacetylation (GO:0070933)3.15968834
81metallo-sulfur cluster assembly (GO:0031163)3.14048367
82iron-sulfur cluster assembly (GO:0016226)3.14048367
83nucleotide salvage (GO:0043173)3.10925566
84glucose 6-phosphate metabolic process (GO:0051156)3.10735272
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10609007
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09856092
87negative regulation of ligase activity (GO:0051352)3.09856092
88rRNA metabolic process (GO:0016072)3.09784550
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09515197
90virion assembly (GO:0019068)3.07611648
91viral protein processing (GO:0019082)3.06892703
92nuclear-transcribed mRNA catabolic process (GO:0000956)3.05153728
93peptidyl-arginine omega-N-methylation (GO:0035247)3.04821425
94spliceosomal complex assembly (GO:0000245)3.03616405
95cellular response to virus (GO:0098586)3.01989532
96ncRNA 3-end processing (GO:0043628)3.01113669
97negative regulation of mRNA processing (GO:0050686)3.00671748
982-oxoglutarate metabolic process (GO:0006103)2.98127912
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.97776833
100pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95496392
101modulation by virus of host morphology or physiology (GO:0019048)2.95420528
102UV protection (GO:0009650)2.94594590
103proline biosynthetic process (GO:0006561)2.94273900
104transcription-coupled nucleotide-excision repair (GO:0006283)2.94229498
105regulation of hydrogen peroxide metabolic process (GO:0010310)2.94147926
106NIK/NF-kappaB signaling (GO:0038061)2.93356718
107protein complex localization (GO:0031503)2.92877687
108IMP metabolic process (GO:0046040)2.92695360
109heme biosynthetic process (GO:0006783)2.92340630
1103-UTR-mediated mRNA stabilization (GO:0070935)2.92327881
111translesion synthesis (GO:0019985)2.92059740
112snRNA processing (GO:0016180)2.92019874
113maternal placenta development (GO:0001893)2.91579685
114protein localization to chromosome, centromeric region (GO:0071459)2.90920592
115nuclear envelope reassembly (GO:0031468)2.90407101
116mitotic nuclear envelope reassembly (GO:0007084)2.90407101
117mitochondrial fusion (GO:0008053)2.88228525
118RNA catabolic process (GO:0006401)2.87843292
119mRNA catabolic process (GO:0006402)2.87818857
120protein targeting to membrane (GO:0006612)2.87420027
121regulation of translational termination (GO:0006449)2.86654295
122regulation of cholesterol biosynthetic process (GO:0045540)2.85866308
123pentose-phosphate shunt (GO:0006098)2.85703819
124regulation of translational fidelity (GO:0006450)2.85522624
125regulation of mitochondrial translation (GO:0070129)2.84826200
126cellular component biogenesis (GO:0044085)2.84511971
1274-hydroxyproline metabolic process (GO:0019471)2.83398502
128endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.82474965
129mitotic metaphase plate congression (GO:0007080)2.81229661
130mitotic G1 DNA damage checkpoint (GO:0031571)2.80451973
131protein deneddylation (GO:0000338)2.79744090
132mRNA splicing, via spliceosome (GO:0000398)2.79583624
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79583624
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79490191
135nuclear envelope organization (GO:0006998)2.78628225
136establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.78049205
137mitochondrion transport along microtubule (GO:0047497)2.78049205
138G1/S transition of mitotic cell cycle (GO:0000082)2.77920174
139cell cycle G1/S phase transition (GO:0044843)2.77920174
140cullin deneddylation (GO:0010388)2.77625703
141Golgi transport vesicle coating (GO:0048200)2.77604834
142COPI coating of Golgi vesicle (GO:0048205)2.77604834
143histone arginine methylation (GO:0034969)2.76936597
144RNA splicing, via transesterification reactions (GO:0000375)2.76371724
145regulation of posttranscriptional gene silencing (GO:0060147)2.76325164
146regulation of gene silencing by miRNA (GO:0060964)2.76325164
147regulation of gene silencing by RNA (GO:0060966)2.76325164
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.75579844
149positive regulation of protein sumoylation (GO:0033235)2.74277102
150pyrimidine-containing compound salvage (GO:0008655)2.73760475
151pyrimidine nucleoside salvage (GO:0043097)2.73760475
152regulation of cholesterol metabolic process (GO:0090181)2.73096273
153peptidyl-arginine methylation (GO:0018216)2.72866053
154peptidyl-arginine N-methylation (GO:0035246)2.72866053
155negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.72534623
156regulation of cholesterol homeostasis (GO:2000188)2.72480238
157entrainment of circadian clock by photoperiod (GO:0043153)2.70544426
158cell-cell junction maintenance (GO:0045217)2.69396589
159regulation of water loss via skin (GO:0033561)2.68851487
160atrioventricular valve morphogenesis (GO:0003181)2.68821525
161amyloid precursor protein catabolic process (GO:0042987)2.67014941
162histone H3 deacetylation (GO:0070932)2.66969481
163NADPH regeneration (GO:0006740)2.65214034
164rRNA transcription (GO:0009303)2.65153376
165negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.63269431
166positive regulation of nuclease activity (GO:0032075)2.62168108
167amyloid precursor protein metabolic process (GO:0042982)2.60694741
168intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.60409583
169nucleosome disassembly (GO:0006337)2.59031520
170protein-DNA complex disassembly (GO:0032986)2.59031520
171regulation of ARF GTPase activity (GO:0032312)2.58998046
172activation of Rac GTPase activity (GO:0032863)2.58768235
173positive regulation of histone deacetylation (GO:0031065)2.57817598
174positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56888363
175autophagic vacuole assembly (GO:0000045)2.56317827
176regulation of chromatin binding (GO:0035561)2.55975465
177glutathione biosynthetic process (GO:0006750)2.52911245
178positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52579990
179lipopolysaccharide biosynthetic process (GO:0009103)2.50902814
180retrograde transport, endosome to Golgi (GO:0042147)2.49756056
181semaphorin-plexin signaling pathway (GO:0071526)2.49625903
182RNA localization (GO:0006403)2.49121153
183post-embryonic morphogenesis (GO:0009886)2.46487510
184regulation of mitochondrial membrane permeability (GO:0046902)2.46473037
185positive regulation of protein deacetylation (GO:0090312)2.46256251
186sulfur amino acid catabolic process (GO:0000098)2.45277288
187epithelial cell differentiation involved in prostate gland development (GO:0060742)2.44346194
188regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.44318691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.95580494
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.36959120
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09835616
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.88127764
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84421470
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83555910
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.78629477
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.77310396
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59504475
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.48815115
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48509372
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.44492151
13XRN2_22483619_ChIP-Seq_HELA_Human2.44417946
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44011204
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39444491
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38110104
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34387812
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21217919
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17310608
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16540973
21DCP1A_22483619_ChIP-Seq_HELA_Human2.07938670
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04546942
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03184040
24* RACK7_27058665_Chip-Seq_MCF-7_Human1.95325877
25GABP_19822575_ChIP-Seq_HepG2_Human1.95008490
26MYC_22102868_ChIP-Seq_BL_Human1.89586602
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88396453
28VDR_23849224_ChIP-Seq_CD4+_Human1.88323614
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86388756
30ZFX_18555785_ChIP-Seq_MESCs_Mouse1.84250172
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79857333
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.78050240
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77642180
34CIITA_25753668_ChIP-Seq_RAJI_Human1.73075286
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71763253
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71665945
37* TTF2_22483619_ChIP-Seq_HELA_Human1.70764731
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66566058
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66406704
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64831077
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.64816523
42FOXP3_21729870_ChIP-Seq_TREG_Human1.62614814
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62324337
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61607014
45AR_21909140_ChIP-Seq_LNCAP_Human1.61134141
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60833109
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.58000489
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57921085
49KDM2B_26808549_Chip-Seq_DND41_Human1.55509067
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54431685
51* SMC4_20622854_ChIP-Seq_HELA_Human1.53700351
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.53098641
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.53074569
54* BCOR_27268052_Chip-Seq_Bcells_Human1.53037924
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52171261
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51637519
57VDR_21846776_ChIP-Seq_THP-1_Human1.51383934
58* TCF7_22412390_ChIP-Seq_EML_Mouse1.51247271
59* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50660551
60* BCL6_27268052_Chip-Seq_Bcells_Human1.49969370
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49730291
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48904317
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.46779260
64KDM5A_27292631_Chip-Seq_BREAST_Human1.44635555
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43526990
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42667825
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41048722
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40904136
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39940052
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37598800
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36975756
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36575181
73PHF8_20622854_ChIP-Seq_HELA_Human1.34229534
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32774982
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32586198
76MAF_26560356_Chip-Seq_TH2_Human1.32511709
77KDM2B_26808549_Chip-Seq_K562_Human1.31849145
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29705450
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.29153498
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.29085365
81NCOR1_26117541_ChIP-Seq_K562_Human1.27979519
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26841085
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26568408
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25878740
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25877011
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.25186546
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.24709904
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24373298
89* TFEB_21752829_ChIP-Seq_HELA_Human1.24167415
90EGR1_19374776_ChIP-ChIP_THP-1_Human1.23401223
91* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23113783
92UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22331924
93* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20195338
94E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19685758
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19662947
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19379585
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.19126044
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18981087
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18040336
100E2F1_20622854_ChIP-Seq_HELA_Human1.17918846
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17794911
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17733780
103ZNF263_19887448_ChIP-Seq_K562_Human1.17679838
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16922755
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16767651
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16528706
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15879336
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15101776
109UTX_26944678_Chip-Seq_JUKART_Human1.14629666
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14224214
111* RARB_24833708_ChIP-Seq_LIVER_Mouse1.14025432
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13510463
113RARA_24833708_ChIP-Seq_LIVER_Mouse1.13243853
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12882556
115MAF_26560356_Chip-Seq_TH1_Human1.12853647
116CTCF_27219007_Chip-Seq_Bcells_Human1.12678610
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12123392
118YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11050062
119CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10761395
120CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10716581
121YY1_22570637_ChIP-Seq_MALME-3M_Human1.10180678
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10092088
123SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09944722
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09910198
125* CTCF_21964334_Chip-Seq_Bcells_Human1.09720087
126SA1_27219007_Chip-Seq_Bcells_Human1.08946235
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06708650
128VDR_24763502_ChIP-Seq_THP-1_Human1.06279022
129* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06045084
130FOXP1_21924763_ChIP-Seq_HESCs_Human1.05471014
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04340859
132ELK3_25401928_ChIP-Seq_HUVEC_Human1.03639207
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02863145
134OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00888383
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00687365
136HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00189803
137* ATF3_27146783_Chip-Seq_COLON_Human0.98615336
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98108135
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.96490819
140SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94189990
141CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93895432
142TET1_21451524_ChIP-Seq_MESCs_Mouse0.92884099
143P68_20966046_ChIP-Seq_HELA_Human0.92855115
144TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92820228
145LXR_22292898_ChIP-Seq_THP-1_Human0.91317030
146ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90778966
147PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.90290283
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89876220
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89673396
150ELF1_20517297_ChIP-Seq_JURKAT_Human0.89358835
151ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86814780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition5.45714507
2MP0003693_abnormal_embryo_hatching5.22317622
3MP0004957_abnormal_blastocyst_morpholog4.62116349
4MP0005058_abnormal_lysosome_morphology4.41700118
5MP0003111_abnormal_nucleus_morphology4.34874007
6MP0010094_abnormal_chromosome_stability3.54922926
7MP0003077_abnormal_cell_cycle3.53026948
8MP0008260_abnormal_autophagy3.49148647
9MP0003172_abnormal_lysosome_physiology3.01579140
10MP0008932_abnormal_embryonic_tissue2.66168818
11MP0001730_embryonic_growth_arrest2.59100632
12MP0008007_abnormal_cellular_replicative2.54824837
13MP0003123_paternal_imprinting2.53679582
14MP0002653_abnormal_ependyma_morphology2.48792283
15MP0004858_abnormal_nervous_system2.42235015
16MP0008057_abnormal_DNA_replication2.36052496
17MP0010234_abnormal_vibrissa_follicle2.34460906
18MP0008058_abnormal_DNA_repair2.33596986
19MP0010352_gastrointestinal_tract_polyps2.23922403
20MP0000350_abnormal_cell_proliferation2.21127997
21MP0002822_catalepsy2.16565721
22MP0002796_impaired_skin_barrier2.14261815
23MP0010030_abnormal_orbit_morphology2.13013874
24MP0004185_abnormal_adipocyte_glucose2.05832402
25MP0003806_abnormal_nucleotide_metabolis2.02076398
26MP0002249_abnormal_larynx_morphology2.01293842
27MP0004264_abnormal_extraembryonic_tissu1.96206351
28MP0002080_prenatal_lethality1.88132926
29MP0001697_abnormal_embryo_size1.85553387
30MP0000490_abnormal_crypts_of1.83099889
31MP0003453_abnormal_keratinocyte_physiol1.78348153
32MP0000537_abnormal_urethra_morphology1.74004571
33MP0003786_premature_aging1.73169782
34MP0003656_abnormal_erythrocyte_physiolo1.72330037
35MP0009840_abnormal_foam_cell1.71729906
36MP0002085_abnormal_embryonic_tissue1.71565037
37MP0003283_abnormal_digestive_organ1.70637998
38MP0002098_abnormal_vibrissa_morphology1.68062801
39MP0002089_abnormal_postnatal_growth/wei1.66698137
40MP0005380_embryogenesis_phenotype1.65546569
41MP0001672_abnormal_embryogenesis/_devel1.65546569
42MP0003191_abnormal_cellular_cholesterol1.64855498
43MP0006054_spinal_hemorrhage1.64798649
44MP0000313_abnormal_cell_death1.54324154
45MP0002084_abnormal_developmental_patter1.52631829
46MP0000358_abnormal_cell_content/1.49421483
47MP0004133_heterotaxia1.48155985
48MP0002254_reproductive_system_inflammat1.47958672
49MP0005666_abnormal_adipose_tissue1.47856996
50MP0003984_embryonic_growth_retardation1.47474212
51MP0002088_abnormal_embryonic_growth/wei1.44109530
52MP0003119_abnormal_digestive_system1.42372175
53MP0003705_abnormal_hypodermis_morpholog1.38637153
54MP0009333_abnormal_splenocyte_physiolog1.37138426
55MP0002019_abnormal_tumor_incidence1.36011659
56MP0004197_abnormal_fetal_growth/weight/1.35604861
57MP0001661_extended_life_span1.33305441
58MP0003436_decreased_susceptibility_to1.33241248
59MP0002086_abnormal_extraembryonic_tissu1.32645137
60MP0003567_abnormal_fetal_cardiomyocyte1.30087433
61MP0006036_abnormal_mitochondrial_physio1.27279676
62MP0002396_abnormal_hematopoietic_system1.25475328
63MP0000003_abnormal_adipose_tissue1.25313681
64MP0004233_abnormal_muscle_weight1.24935380
65MP0005375_adipose_tissue_phenotype1.23983275
66MP0000750_abnormal_muscle_regeneration1.23427019
67MP0001873_stomach_inflammation1.23176323
68MP0008877_abnormal_DNA_methylation1.22511022
69MP0010307_abnormal_tumor_latency1.16169606
70MP0000566_synostosis1.15711950
71MP0009384_cardiac_valve_regurgitation1.14548298
72MP0005076_abnormal_cell_differentiation1.12151100
73MP0001727_abnormal_embryo_implantation1.10118452
74MP0001145_abnormal_male_reproductive1.09894804
75MP0002210_abnormal_sex_determination1.09129202
76MP0003221_abnormal_cardiomyocyte_apopto1.08456320
77MP0003186_abnormal_redox_activity1.07999885
78MP0005360_urolithiasis1.07377244
79MP0004947_skin_inflammation1.06252470
80MP0005397_hematopoietic_system_phenotyp1.05361439
81MP0001545_abnormal_hematopoietic_system1.05361439
82MP0001293_anophthalmia1.03924134
83MP0002269_muscular_atrophy1.02582687
84MP0000858_altered_metastatic_potential1.00540718
85MP0000681_abnormal_thyroid_gland1.00140412
86MP0003315_abnormal_perineum_morphology0.99774209
87MP0002139_abnormal_hepatobiliary_system0.99318773
88MP0000462_abnormal_digestive_system0.98720842
89MP0001348_abnormal_lacrimal_gland0.98279481
90MP0005384_cellular_phenotype0.95661835
91MP0000428_abnormal_craniofacial_morphol0.95652718
92MP0005670_abnormal_white_adipose0.95542805
93MP0009931_abnormal_skin_appearance0.95326204
94MP0008875_abnormal_xenobiotic_pharmacok0.95046903
95MP0000747_muscle_weakness0.95035606
96MP0005310_abnormal_salivary_gland0.94729644
97MP0005023_abnormal_wound_healing0.94571089
98MP0000609_abnormal_liver_physiology0.93439711
99MP0001764_abnormal_homeostasis0.92708560
100MP0002970_abnormal_white_adipose0.90164396
101MP0000733_abnormal_muscle_development0.90118104
102MP0001216_abnormal_epidermal_layer0.89378695
103MP0006035_abnormal_mitochondrial_morpho0.89378165
104MP0005621_abnormal_cell_physiology0.87438168
105MP0001929_abnormal_gametogenesis0.86719575
106MP0000703_abnormal_thymus_morphology0.86603248
107MP0002111_abnormal_tail_morphology0.86241946
108MP0008995_early_reproductive_senescence0.85157922
109MP0010771_integument_phenotype0.83568209
110MP0005501_abnormal_skin_physiology0.83355451
111MP0003329_amyloid_beta_deposits0.82447799
112MP0003718_maternal_effect0.82416123
113MP0004084_abnormal_cardiac_muscle0.81628767
114MP0003878_abnormal_ear_physiology0.81598767
115MP0005377_hearing/vestibular/ear_phenot0.81598767
116MP0003879_abnormal_hair_cell0.81344163
117MP0009672_abnormal_birth_weight0.81278722
118MP0003566_abnormal_cell_adhesion0.80431931
119MP0001849_ear_inflammation0.80406360
120MP0009053_abnormal_anal_canal0.80139234
121MP0005330_cardiomyopathy0.80033158
122MP0005220_abnormal_exocrine_pancreas0.78652880
123MP0000477_abnormal_intestine_morphology0.78457849
124MP0000653_abnormal_sex_gland0.76746042
125MP0005464_abnormal_platelet_physiology0.76231906
126MP0003115_abnormal_respiratory_system0.76140410
127MP0004147_increased_porphyrin_level0.76081535
128MP0009278_abnormal_bone_marrow0.75708081
129MP0000598_abnormal_liver_morphology0.74793740
130MP0005365_abnormal_bile_salt0.74398041
131MP0005319_abnormal_enzyme/_coenzyme0.73439288
132MP0009643_abnormal_urine_homeostasis0.72683455
133MP0004808_abnormal_hematopoietic_stem0.71691824
134MP0002722_abnormal_immune_system0.70487772
135MP0000678_abnormal_parathyroid_gland0.70353305
136MP0002160_abnormal_reproductive_system0.68898537
137MP0008874_decreased_physiological_sensi0.66952312
138MP0000470_abnormal_stomach_morphology0.65961797
139MP0002092_abnormal_eye_morphology0.62190752
140MP0002398_abnormal_bone_marrow0.61552868
141MP0002132_abnormal_respiratory_system0.61354455
142MP0002234_abnormal_pharynx_morphology0.60939666
143MP0008770_decreased_survivor_rate0.60368445
144MP0002429_abnormal_blood_cell0.60217969
145MP0000467_abnormal_esophagus_morphology0.60114621
146MP0005584_abnormal_enzyme/coenzyme_acti0.59651843
147MP0001346_abnormal_lacrimal_gland0.58376938
148MP0005266_abnormal_metabolism0.58372355
149MP0005025_abnormal_response_to0.58337058
150MP0010630_abnormal_cardiac_muscle0.57582356
151MP0001881_abnormal_mammary_gland0.57479135
152MP0003763_abnormal_thymus_physiology0.57029600
153MP0003121_genomic_imprinting0.55722070
154MP0000689_abnormal_spleen_morphology0.55705877
155MP0003942_abnormal_urinary_system0.55299410
156MP0000534_abnormal_ureter_morphology0.54968710
157MP0005389_reproductive_system_phenotype0.54620545
158MP0005083_abnormal_biliary_tract0.54581318
159MP0002932_abnormal_joint_morphology0.54363100

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.79857198
2Reticulocytopenia (HP:0001896)4.73239329
3Abnormal number of erythroid precursors (HP:0012131)4.68265378
4Progressive muscle weakness (HP:0003323)4.16339396
5Breast hypoplasia (HP:0003187)4.08585012
6Cerebral hypomyelination (HP:0006808)3.88714564
7Birth length less than 3rd percentile (HP:0003561)3.79265479
8J-shaped sella turcica (HP:0002680)3.76486590
9Hyperacusis (HP:0010780)3.54950972
10Truncus arteriosus (HP:0001660)3.50188520
11Macrocytic anemia (HP:0001972)3.42164268
12Microretrognathia (HP:0000308)3.39289595
13Pallor (HP:0000980)3.38815243
14Ependymoma (HP:0002888)3.36819150
15Trismus (HP:0000211)3.36743215
16Reticulocytosis (HP:0001923)3.28736897
17Hyperthyroidism (HP:0000836)3.28620086
18Oral leukoplakia (HP:0002745)3.23389763
19Selective tooth agenesis (HP:0001592)3.18886484
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17032631
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17032631
22Multiple enchondromatosis (HP:0005701)3.16792203
23Seborrheic dermatitis (HP:0001051)3.05613899
24Abnormality of the anterior horn cell (HP:0006802)3.04996710
25Degeneration of anterior horn cells (HP:0002398)3.04996710
26Stridor (HP:0010307)3.04093427
27Aplastic anemia (HP:0001915)3.04088406
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96378709
29Rough bone trabeculation (HP:0100670)2.88978257
30Carpal bone hypoplasia (HP:0001498)2.87739971
31Abnormal gallbladder physiology (HP:0012438)2.86005149
32Cholecystitis (HP:0001082)2.86005149
33Dysostosis multiplex (HP:0000943)2.84191974
34Increased cerebral lipofuscin (HP:0011813)2.80662227
35Increased neuronal autofluorescent lipopigment (HP:0002074)2.78417686
36Hemorrhage of the eye (HP:0011885)2.75391190
37Premature ovarian failure (HP:0008209)2.73717727
38Secondary amenorrhea (HP:0000869)2.73518800
39Colon cancer (HP:0003003)2.72074035
40Abnormality of reticulocytes (HP:0004312)2.66134846
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.64167657
42Microvesicular hepatic steatosis (HP:0001414)2.58505054
43Hypertensive crisis (HP:0100735)2.58455554
44Thoracic kyphosis (HP:0002942)2.57944536
45Abnormality of polysaccharide metabolism (HP:0011012)2.53457793
46Abnormality of glycosaminoglycan metabolism (HP:0004371)2.53457793
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.53457793
48Broad distal phalanx of finger (HP:0009836)2.52557062
49Abnormality of the thoracic spine (HP:0100711)2.52425427
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51650426
51Long palpebral fissure (HP:0000637)2.51199998
52Distal lower limb amyotrophy (HP:0008944)2.50400602
53Vertebral compression fractures (HP:0002953)2.48990908
54Prolonged neonatal jaundice (HP:0006579)2.48182625
55Neoplasm of the pancreas (HP:0002894)2.43857170
56Patellar aplasia (HP:0006443)2.43580380
57Absent thumb (HP:0009777)2.41517387
58Abnormality of liposaccharide metabolism (HP:0010968)2.39933172
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.39933172
60Abnormality of glycolipid metabolism (HP:0010969)2.39933172
61Slender long bone (HP:0003100)2.38765365
62Aplasia/Hypoplasia of the patella (HP:0006498)2.37502504
63Angiofibromas (HP:0010615)2.33608925
64Adenoma sebaceum (HP:0009720)2.33608925
65Absent radius (HP:0003974)2.29882361
66Mucopolysacchariduria (HP:0008155)2.29228651
67Urinary glycosaminoglycan excretion (HP:0003541)2.29228651
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.28769598
69Distal lower limb muscle weakness (HP:0009053)2.27112249
70Ankle clonus (HP:0011448)2.26531104
71Bowel incontinence (HP:0002607)2.26347072
7211 pairs of ribs (HP:0000878)2.26176452
73Horseshoe kidney (HP:0000085)2.25281149
74Abnormal large intestine physiology (HP:0012700)2.25157409
75Cerebral palsy (HP:0100021)2.24030948
76Neuronal loss in central nervous system (HP:0002529)2.20995060
77Insomnia (HP:0100785)2.20442332
78Hypoparathyroidism (HP:0000829)2.19379510
79Difficulty climbing stairs (HP:0003551)2.19055295
80Mesangial abnormality (HP:0001966)2.17150441
81Poor head control (HP:0002421)2.16877965
82Megaloblastic anemia (HP:0001889)2.14816032
83Basal cell carcinoma (HP:0002671)2.14376292
84Missing ribs (HP:0000921)2.13942164
85Bulbar palsy (HP:0001283)2.12704893
86Absent forearm bone (HP:0003953)2.09858719
87Aplasia involving forearm bones (HP:0009822)2.09858719
88Deep venous thrombosis (HP:0002625)2.09801691
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09674777
90Abnormality of alanine metabolism (HP:0010916)2.09674777
91Hyperalaninemia (HP:0003348)2.09674777
92Unsteady gait (HP:0002317)2.09422552
93Hand muscle atrophy (HP:0009130)2.05833514
94Emotional lability (HP:0000712)2.05494878
95Increased serum lactate (HP:0002151)2.04797641
96Flattened epiphyses (HP:0003071)2.04588952
97Atrophy/Degeneration involving motor neurons (HP:0007373)2.03526407
98Ragged-red muscle fibers (HP:0003200)2.03350973
99Atelectasis (HP:0100750)2.03171133
100Abnormal hair laboratory examination (HP:0003328)2.03167808
101Abnormality of the umbilical cord (HP:0010881)2.01321413
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01000383
103Achilles tendon contracture (HP:0001771)1.99754674
104Postnatal microcephaly (HP:0005484)1.99580683
105Easy fatigability (HP:0003388)1.99500919
106Myopathic facies (HP:0002058)1.97041257
107Cervical subluxation (HP:0003308)1.95179249
108Pili torti (HP:0003777)1.94937033
109Metaphyseal cupping (HP:0003021)1.93850887
110Loss of speech (HP:0002371)1.90376679
111Abnormality of the ileum (HP:0001549)1.89569028
112Overriding aorta (HP:0002623)1.89454568
113Short nail (HP:0001799)1.88865880
114Personality changes (HP:0000751)1.88699663
115Meckel diverticulum (HP:0002245)1.88449809
116Growth hormone excess (HP:0000845)1.88219958
117CNS hypomyelination (HP:0003429)1.87905082
118Progressive neurologic deterioration (HP:0002344)1.86610331
119Nuclear cataract (HP:0100018)1.85914408
120Obstructive sleep apnea (HP:0002870)1.85832723
121Abnormality of the calcaneus (HP:0008364)1.84909862
122Deep palmar crease (HP:0006191)1.84507437
123Cholelithiasis (HP:0001081)1.84165423
124Atresia of the external auditory canal (HP:0000413)1.82948800
125Premature graying of hair (HP:0002216)1.82527416
126Pancytopenia (HP:0001876)1.81717123
127Patellar dislocation (HP:0002999)1.81640049
128Patent foramen ovale (HP:0001655)1.80212988
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80192135
130Concave nail (HP:0001598)1.79142730
131Tongue fasciculations (HP:0001308)1.78420912
132External ophthalmoplegia (HP:0000544)1.78232291
133Hypoplasia of the pons (HP:0012110)1.77856551
134Gastrointestinal dysmotility (HP:0002579)1.77559835
135Pointed chin (HP:0000307)1.77272972
136Muscle fibrillation (HP:0010546)1.77228887
137Hepatic necrosis (HP:0002605)1.76220856
138Calcaneovalgus deformity (HP:0001848)1.76008087
139Cellulitis (HP:0100658)1.75921374
140Germ cell neoplasia (HP:0100728)1.75524695
141Upper limb amyotrophy (HP:0009129)1.75457193
142Distal upper limb amyotrophy (HP:0007149)1.75457193
143Opisthotonus (HP:0002179)1.75240869
144Abdominal distention (HP:0003270)1.73642797
145Abnormal trabecular bone morphology (HP:0100671)1.73343776
146Hypertriglyceridemia (HP:0002155)1.73300109
147Abnormality of abdominal situs (HP:0011620)1.73162444
148Abdominal situs inversus (HP:0003363)1.73162444
149Spastic paraparesis (HP:0002313)1.73153288
150Lymphangioma (HP:0100764)1.72680014
151Thin bony cortex (HP:0002753)1.72059111
152Abnormality of lateral ventricle (HP:0030047)1.71932422
153Abnormality of the gallbladder (HP:0005264)1.71840365
154Testicular neoplasm (HP:0010788)1.71342170
155Exercise-induced myalgia (HP:0003738)1.70746764
156Hypokinesia (HP:0002375)1.70315154
157Abnormality of iron homeostasis (HP:0011031)1.69992436
158Posterior subcapsular cataract (HP:0007787)1.69967535
159Ankle contracture (HP:0006466)1.69956421
160Hepatocellular necrosis (HP:0001404)1.69550501
161Testicular atrophy (HP:0000029)1.69202401
162Acanthosis nigricans (HP:0000956)1.68533116
163Renal duplication (HP:0000075)1.67427227
164Aplasia/hypoplasia of the humerus (HP:0006507)1.67285356
165Abnormality of the Achilles tendon (HP:0005109)1.67264265
166Gout (HP:0001997)1.67026457
167Protrusio acetabuli (HP:0003179)1.66960325
168Glossoptosis (HP:0000162)1.65701900
169Poikiloderma (HP:0001029)1.65274841
170High pitched voice (HP:0001620)1.65232217
171Cerebellar dysplasia (HP:0007033)1.63953054
172Increased serum ferritin (HP:0003281)1.63590067
173Delusions (HP:0000746)1.60966112
174Abnormal number of incisors (HP:0011064)1.60759261
175Aplasia/hypoplasia of the uterus (HP:0008684)1.60377014
176Diaphragmatic weakness (HP:0009113)1.60302627
177Abnormality of the astrocytes (HP:0100707)1.58179043
178Astrocytoma (HP:0009592)1.58179043
179Abnormality of the pons (HP:0007361)1.57181649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44812216
2SMG13.51033055
3IRAK33.49663539
4WEE13.45441195
5TESK23.31161039
6TLK12.98942725
7EIF2AK12.91651137
8SIK12.84035423
9NME22.81681101
10CDC72.71040651
11NEK22.46310468
12SCYL22.39851975
13TRIB32.24418491
14PASK2.15448333
15PRPF4B2.08796639
16NEK12.03347997
17EPHA21.98758334
18MAP3K101.97997340
19STK161.95266553
20MAP3K111.93422526
21VRK21.89138233
22TTK1.84375707
23BCKDK1.83956380
24TESK11.82991847
25DYRK31.73571126
26PKN21.66524587
27BRSK21.59212279
28RPS6KA41.56384742
29ARAF1.54573921
30KDR1.54223850
31BRSK11.53351059
32ERN11.52890850
33FLT31.52685478
34PAK41.49948695
35PLK11.49160574
36AURKA1.48709291
37RPS6KB21.47433705
38TAOK11.47378235
39CDK71.43567214
40EEF2K1.42864170
41ACVR1B1.42719102
42MAP3K81.40797520
43BMX1.36722228
44IRAK21.29399518
45MAPKAPK31.29030236
46SRPK11.24514139
47EIF2AK31.21753230
48VRK11.21042321
49SIK21.20709241
50FGFR41.20623088
51MST1R1.20209831
52TSSK61.19825132
53TBK11.18675864
54LRRK21.17118704
55AURKB1.17037301
56MAP2K21.16631169
57PRKD21.14721611
58STK101.14184073
59RIPK11.09080292
60NME11.03154083
61MAP3K11.01967349
62LMTK21.00689516
63ATR0.99742259
64CDK120.98322015
65CDK40.97491423
66PAK10.95009507
67TNK20.93349278
68PIM20.91384026
69CHEK20.89095490
70LIMK10.88822188
71IRAK40.88761704
72MARK20.87415995
73CDK190.85102208
74ABL20.83845274
75MAP3K30.83154965
76CHEK10.82758506
77MAP2K60.82495410
78ILK0.82297348
79DAPK10.81144853
80PRKD30.80728986
81PDPK10.72810732
82TAOK20.72783179
83PRKCI0.72401441
84TGFBR10.71479873
85MAP4K10.67274961
86BRAF0.65953691
87BLK0.63331331
88MAP3K130.61902169
89DAPK30.61107595
90UHMK10.60289533
91CDK20.59164928
92AKT20.58954702
93RPS6KA20.58391415
94PLK40.57670291
95CDC42BPA0.56430560
96HIPK20.56256751
97PAK20.55679507
98ICK0.55548437
99ZAP700.55150272
100MTOR0.53350185
101CHUK0.53264947
102TTN0.51646361
103IKBKB0.51501092
104MAP2K30.51094754
105CDK90.49592957
106CSNK2A20.49515562
107TYRO30.48361544
108MAPK110.47832765
109PTK20.46574760
110RPS6KL10.46300424
111RPS6KC10.46300424
112IRAK10.45579261
113ALK0.45310292
114MAP3K70.45025977
115CSNK2A10.44221497
116PLK30.43969857
117EPHB10.43741685
118STK40.40986886
119MUSK0.39574330
120MAPK150.39393677
121MAPK120.39366699
122DYRK1B0.39021421
123MET0.38043598
124DYRK20.37073553
125GRK60.35471305
126CAMKK10.34970187
127CAMK2G0.34768612
128CAMK1D0.34036338
129PIM10.33744060
130RPS6KA50.32865851
131PTK60.32174658
132IKBKE0.31832964
133MKNK10.31717852
134ATM0.31543699
135CDK11A0.31162139
136PDGFRA0.31088067
137KSR20.30595809
138MELK0.30496263
139RPS6KA10.30292534
140RPS6KA60.29774864
141CDK140.29762376
142PDK30.29429945
143PDK40.29429945
144CDK10.29102055
145MAPKAPK20.28997009
146CSNK1E0.28834668
147MAP2K40.28660853
148SIK30.28402119
149PRKG20.27340956
150LATS20.27039509
151PDK10.25930658

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17982773
2Ribosome_Homo sapiens_hsa030104.22492574
3Mismatch repair_Homo sapiens_hsa034304.04483909
4Proteasome_Homo sapiens_hsa030503.41460390
5Spliceosome_Homo sapiens_hsa030403.23678964
6Base excision repair_Homo sapiens_hsa034103.01055202
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88708016
8RNA transport_Homo sapiens_hsa030132.78953780
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.77702718
10RNA polymerase_Homo sapiens_hsa030202.68948272
11Nucleotide excision repair_Homo sapiens_hsa034202.68088638
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.60890867
13Homologous recombination_Homo sapiens_hsa034402.51827828
14One carbon pool by folate_Homo sapiens_hsa006702.45777767
15Pyrimidine metabolism_Homo sapiens_hsa002402.35916181
16Cell cycle_Homo sapiens_hsa041102.35059428
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06520762
18Sulfur relay system_Homo sapiens_hsa041221.92796297
19Folate biosynthesis_Homo sapiens_hsa007901.82255147
20Vibrio cholerae infection_Homo sapiens_hsa051101.64907964
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.60071516
22Protein export_Homo sapiens_hsa030601.49161308
23Fanconi anemia pathway_Homo sapiens_hsa034601.48680725
24p53 signaling pathway_Homo sapiens_hsa041151.45386641
25Biosynthesis of amino acids_Homo sapiens_hsa012301.41374885
26Phenylalanine metabolism_Homo sapiens_hsa003601.39271048
27Pentose phosphate pathway_Homo sapiens_hsa000301.37051070
28mRNA surveillance pathway_Homo sapiens_hsa030151.35448944
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34640880
30RNA degradation_Homo sapiens_hsa030181.27585259
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24871994
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22689961
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.19676530
34Selenocompound metabolism_Homo sapiens_hsa004501.18486780
35Basal transcription factors_Homo sapiens_hsa030221.11238528
36Purine metabolism_Homo sapiens_hsa002301.10467441
37Insulin signaling pathway_Homo sapiens_hsa049101.10250469
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.09321499
39Carbon metabolism_Homo sapiens_hsa012001.08650145
40Hepatitis C_Homo sapiens_hsa051601.08551625
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.06641353
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06101553
43Prion diseases_Homo sapiens_hsa050201.05889143
44Arginine biosynthesis_Homo sapiens_hsa002201.05066351
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04671226
46AMPK signaling pathway_Homo sapiens_hsa041521.04000498
47Parkinsons disease_Homo sapiens_hsa050121.01220773
48N-Glycan biosynthesis_Homo sapiens_hsa005101.00205376
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.99329955
50Synaptic vesicle cycle_Homo sapiens_hsa047210.98822891
51Bladder cancer_Homo sapiens_hsa052190.98680301
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96834047
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94219989
54Non-small cell lung cancer_Homo sapiens_hsa052230.93463343
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.91183401
56Thyroid cancer_Homo sapiens_hsa052160.90595333
57Epstein-Barr virus infection_Homo sapiens_hsa051690.87184765
58Oocyte meiosis_Homo sapiens_hsa041140.85365832
59Systemic lupus erythematosus_Homo sapiens_hsa053220.85343348
60Huntingtons disease_Homo sapiens_hsa050160.84977900
61Non-homologous end-joining_Homo sapiens_hsa034500.84791455
62Sphingolipid metabolism_Homo sapiens_hsa006000.84501018
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83871157
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82958364
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81218475
66B cell receptor signaling pathway_Homo sapiens_hsa046620.79555027
67Viral carcinogenesis_Homo sapiens_hsa052030.79353282
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79111473
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.76935267
70Lysine degradation_Homo sapiens_hsa003100.76067446
71Oxidative phosphorylation_Homo sapiens_hsa001900.74330988
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73885251
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.72052856
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70378061
75Endocytosis_Homo sapiens_hsa041440.70316925
76ErbB signaling pathway_Homo sapiens_hsa040120.70297618
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69925389
78Inositol phosphate metabolism_Homo sapiens_hsa005620.69737093
79Insulin resistance_Homo sapiens_hsa049310.69309955
80Fructose and mannose metabolism_Homo sapiens_hsa000510.68892556
81Glutathione metabolism_Homo sapiens_hsa004800.66708558
82HTLV-I infection_Homo sapiens_hsa051660.65966678
83Collecting duct acid secretion_Homo sapiens_hsa049660.65793880
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61364240
85Pancreatic cancer_Homo sapiens_hsa052120.61136284
86Antigen processing and presentation_Homo sapiens_hsa046120.60640369
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60594969
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60415788
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59426858
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.58644366
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57652844
92Endometrial cancer_Homo sapiens_hsa052130.57309186
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.53783665
94Tyrosine metabolism_Homo sapiens_hsa003500.53244084
95Galactose metabolism_Homo sapiens_hsa000520.53120366
96Herpes simplex infection_Homo sapiens_hsa051680.51452835
97Salmonella infection_Homo sapiens_hsa051320.51388791
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.50315416
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49376600
100Shigellosis_Homo sapiens_hsa051310.49349882
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49299208
102Fatty acid elongation_Homo sapiens_hsa000620.48093495
103Notch signaling pathway_Homo sapiens_hsa043300.47680079
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47235086
105Small cell lung cancer_Homo sapiens_hsa052220.46493724
106Legionellosis_Homo sapiens_hsa051340.46270753
107Arginine and proline metabolism_Homo sapiens_hsa003300.46248933
108Alcoholism_Homo sapiens_hsa050340.44364869
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.43658584
110Hippo signaling pathway_Homo sapiens_hsa043900.42785386
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.40762387
112Apoptosis_Homo sapiens_hsa042100.38790344
113Pyruvate metabolism_Homo sapiens_hsa006200.37889819
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37250188
115Choline metabolism in cancer_Homo sapiens_hsa052310.36637230
116Chronic myeloid leukemia_Homo sapiens_hsa052200.36150326
117Acute myeloid leukemia_Homo sapiens_hsa052210.33921279
118Basal cell carcinoma_Homo sapiens_hsa052170.33636540
119TNF signaling pathway_Homo sapiens_hsa046680.33630544
120Fatty acid metabolism_Homo sapiens_hsa012120.33285591
121Regulation of autophagy_Homo sapiens_hsa041400.32622711
122Metabolic pathways_Homo sapiens_hsa011000.32470258
123Prolactin signaling pathway_Homo sapiens_hsa049170.31842402
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30662160
125Influenza A_Homo sapiens_hsa051640.30025307
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29589046
127Hedgehog signaling pathway_Homo sapiens_hsa043400.29555236
128Alzheimers disease_Homo sapiens_hsa050100.28787940
129Glucagon signaling pathway_Homo sapiens_hsa049220.28299434
130Hepatitis B_Homo sapiens_hsa051610.27830835
131Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27828626
132Vitamin B6 metabolism_Homo sapiens_hsa007500.26614097
133VEGF signaling pathway_Homo sapiens_hsa043700.26428622
134MicroRNAs in cancer_Homo sapiens_hsa052060.25174851
135Fat digestion and absorption_Homo sapiens_hsa049750.20614243
136mTOR signaling pathway_Homo sapiens_hsa041500.20221325
137Other glycan degradation_Homo sapiens_hsa005110.19602798
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19311778
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19146030
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18849716
141Cardiac muscle contraction_Homo sapiens_hsa042600.17825272
142HIF-1 signaling pathway_Homo sapiens_hsa040660.17700918
143Tight junction_Homo sapiens_hsa045300.15512870
144Colorectal cancer_Homo sapiens_hsa052100.14852777
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13503296
146Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.13105171
147TGF-beta signaling pathway_Homo sapiens_hsa043500.11056385
148Pathways in cancer_Homo sapiens_hsa052000.10103383
149Lysosome_Homo sapiens_hsa041420.10072493

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