GEMIN8P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein K6-linked ubiquitination (GO:0085020)4.74239914
2regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.73246562
3negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.64714715
4proteasome assembly (GO:0043248)4.44250949
5mitotic metaphase plate congression (GO:0007080)4.43488196
6regulation of mitochondrial translation (GO:0070129)4.33473975
7metaphase plate congression (GO:0051310)4.10551894
8regulation of retinoic acid receptor signaling pathway (GO:0048385)4.02388521
9mitotic sister chromatid segregation (GO:0000070)4.01796941
10establishment of integrated proviral latency (GO:0075713)4.00351064
11anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89427811
12protein localization to kinetochore (GO:0034501)3.87290445
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85462521
14protein localization to chromosome, centromeric region (GO:0071459)3.85192366
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82340555
16positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76307590
17regulation of spindle organization (GO:0090224)3.75429403
18DNA ligation (GO:0006266)3.74696908
19negative regulation of chromosome segregation (GO:0051985)3.68239970
20ribosome assembly (GO:0042255)3.66350648
21spindle checkpoint (GO:0031577)3.65455746
22negative regulation of mitotic sister chromatid separation (GO:2000816)3.62584024
23negative regulation of sister chromatid segregation (GO:0033046)3.62584024
24negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62584024
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.62584024
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62584024
27regulation of mitotic spindle organization (GO:0060236)3.60401535
28mitotic spindle checkpoint (GO:0071174)3.58872149
29establishment of viral latency (GO:0019043)3.58463338
30sister chromatid segregation (GO:0000819)3.57516447
31mitotic spindle assembly checkpoint (GO:0007094)3.56057078
32mitotic chromosome condensation (GO:0007076)3.52571750
33negative regulation of ligase activity (GO:0051352)3.52211234
34negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52211234
35synapsis (GO:0007129)3.51290543
36spindle assembly checkpoint (GO:0071173)3.50141685
37regulation of chromosome segregation (GO:0051983)3.44113502
38protein refolding (GO:0042026)3.42966112
39positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.42121380
40protein complex localization (GO:0031503)3.32540153
41chaperone mediated protein folding requiring cofactor (GO:0051085)3.32499461
42cellular protein complex localization (GO:0034629)3.30991367
43mitotic nuclear envelope disassembly (GO:0007077)3.28116197
44positive regulation of ligase activity (GO:0051351)3.27089520
45DNA strand elongation involved in DNA replication (GO:0006271)3.25248297
46regulation of ubiquitin-protein transferase activity (GO:0051438)3.22727759
47DNA strand elongation (GO:0022616)3.22712279
48nuclear pore complex assembly (GO:0051292)3.17529412
49microtubule depolymerization (GO:0007019)3.17399002
50regulation of mitotic sister chromatid segregation (GO:0033047)3.15385016
51regulation of sister chromatid segregation (GO:0033045)3.15385016
52regulation of mitotic sister chromatid separation (GO:0010965)3.15385016
53CENP-A containing nucleosome assembly (GO:0034080)3.14764700
54establishment of chromosome localization (GO:0051303)3.11823365
55regulation of ligase activity (GO:0051340)3.10849898
56membrane disassembly (GO:0030397)3.10780394
57nuclear envelope disassembly (GO:0051081)3.10780394
58protein localization to chromosome (GO:0034502)3.10388442
59regulation of cellular amino acid metabolic process (GO:0006521)3.09963447
60regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08862479
61regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08862479
62attachment of spindle microtubules to kinetochore (GO:0008608)3.08432666
63telomere maintenance via semi-conservative replication (GO:0032201)3.02203769
64negative regulation of mitosis (GO:0045839)2.98519132
65chromatin remodeling at centromere (GO:0031055)2.98249835
66nucleotide-excision repair, DNA gap filling (GO:0006297)2.93530372
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91890844
68positive regulation of chromosome segregation (GO:0051984)2.89895131
69DNA replication checkpoint (GO:0000076)2.89069889
70tRNA aminoacylation for protein translation (GO:0006418)2.86432234
71de novo posttranslational protein folding (GO:0051084)2.86357217
72male meiosis I (GO:0007141)2.85700334
73de novo protein folding (GO:0006458)2.84284987
74tricarboxylic acid cycle (GO:0006099)2.84131187
75mitochondrial RNA metabolic process (GO:0000959)2.83729463
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81113704
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81113704
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81113704
79ribosome biogenesis (GO:0042254)2.80519421
80respiratory chain complex IV assembly (GO:0008535)2.80206449
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.80091089
82peptidyl-arginine omega-N-methylation (GO:0035247)2.78530189
83formation of translation preinitiation complex (GO:0001731)2.78502762
84nuclear pore organization (GO:0006999)2.78366191
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77575883
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77575883
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77460567
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.77460567
89amino acid activation (GO:0043038)2.75376709
90tRNA aminoacylation (GO:0043039)2.75376709
91peptidyl-arginine methylation (GO:0018216)2.74410265
92peptidyl-arginine N-methylation (GO:0035246)2.74410265
93negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.74228457
94signal transduction involved in cell cycle checkpoint (GO:0072395)2.72475767
95rRNA modification (GO:0000154)2.71904041
96ventricular cardiac muscle cell development (GO:0055015)2.71517126
97transcription from mitochondrial promoter (GO:0006390)2.69396753
98protein K11-linked ubiquitination (GO:0070979)2.67098872
99chromosome segregation (GO:0007059)2.67093435
100resolution of meiotic recombination intermediates (GO:0000712)2.65299942

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.97436191
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.58183596
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.00617661
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70436498
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61084167
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.48891139
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.43660700
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43081355
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39565551
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36517424
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.32721804
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21512238
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.21250118
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20325980
15ETS1_20019798_ChIP-Seq_JURKAT_Human3.07793672
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94238663
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78861164
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78558555
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64091066
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.55949478
21DCP1A_22483619_ChIP-Seq_HELA_Human2.48454204
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40260975
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38949303
24XRN2_22483619_ChIP-Seq_HELA_Human2.31716260
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29242205
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22760215
27GABP_19822575_ChIP-Seq_HepG2_Human2.20055608
28VDR_23849224_ChIP-Seq_CD4+_Human2.18777456
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17551603
30MYCN_18555785_ChIP-Seq_MESCs_Mouse2.12871141
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.08632949
32AR_21909140_ChIP-Seq_LNCAP_Human2.06320771
33* TTF2_22483619_ChIP-Seq_HELA_Human2.03388381
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99774416
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.97316509
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.94455503
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.93363198
38FOXP3_21729870_ChIP-Seq_TREG_Human1.92233624
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.92027886
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85053007
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81368344
42ELK1_19687146_ChIP-ChIP_HELA_Human1.79144167
43KDM5A_27292631_Chip-Seq_BREAST_Human1.74760482
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69866666
45ZNF263_19887448_ChIP-Seq_K562_Human1.65121084
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58725736
47TFEB_21752829_ChIP-Seq_HELA_Human1.56860689
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56033551
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52502153
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50929715
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.49591655
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47385759
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46094381
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44746401
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43721210
56MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39000814
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37119117
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.36398778
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30489737
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30232006
61SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26319081
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24934321
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24543577
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23665018
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17096194
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16501175
67CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14486986
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13238594
69CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11499579
70MYC_18940864_ChIP-ChIP_HL60_Human1.07637722
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07081354
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05977710
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04088245
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00206656
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00073113
76TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97614013
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97510666
78NANOG_21062744_ChIP-ChIP_HESCs_Human0.96386595
79CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95423331
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94840857
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94598998
82CIITA_25753668_ChIP-Seq_RAJI_Human0.92810775
83SOX17_20123909_ChIP-Seq_XEN_Mouse0.90978346
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90686042
85STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89413880
86CHD1_26751641_Chip-Seq_LNCaP_Human0.88944290
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88157805
88TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86970237
89SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86812360
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84079729
91TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.80789183
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79634386
93GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72817657
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.72561577
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.71220107
96SOX2_16153702_ChIP-ChIP_HESCs_Human0.71127076
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69682734
98FOXP1_21924763_ChIP-Seq_HESCs_Human0.68544177
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.68044283
100NANOG_16153702_ChIP-ChIP_HESCs_Human0.66525639

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.39853791
2MP0008058_abnormal_DNA_repair4.05890735
3MP0003693_abnormal_embryo_hatching3.97137493
4MP0004957_abnormal_blastocyst_morpholog3.44037186
5MP0010094_abnormal_chromosome_stability3.42647430
6MP0003077_abnormal_cell_cycle3.12729710
7MP0003718_maternal_effect2.90793145
8MP0008932_abnormal_embryonic_tissue2.57457839
9MP0003786_premature_aging2.52759414
10MP0008007_abnormal_cellular_replicative2.49678362
11MP0006036_abnormal_mitochondrial_physio2.48933239
12MP0006035_abnormal_mitochondrial_morpho2.11036045
13MP0010307_abnormal_tumor_latency2.00332854
14MP0009697_abnormal_copulation2.00329259
15MP0000678_abnormal_parathyroid_gland1.96913855
16MP0006292_abnormal_olfactory_placode1.95616799
17MP0005083_abnormal_biliary_tract1.93221062
18MP0003195_calcinosis1.88437197
19MP0001730_embryonic_growth_arrest1.88366699
20MP0003186_abnormal_redox_activity1.86129638
21MP0003806_abnormal_nucleotide_metabolis1.83400561
22MP0003656_abnormal_erythrocyte_physiolo1.80998276
23MP0008260_abnormal_autophagy1.73084942
24MP0004147_increased_porphyrin_level1.72899346
25MP0008995_early_reproductive_senescence1.71577989
26MP0008877_abnormal_DNA_methylation1.67730606
27MP0006072_abnormal_retinal_apoptosis1.63624683
28MP0000350_abnormal_cell_proliferation1.63621042
29MP0001529_abnormal_vocalization1.58430974
30MP0001929_abnormal_gametogenesis1.54811703
31MP0001697_abnormal_embryo_size1.52684287
32MP0002210_abnormal_sex_determination1.52371953
33MP0009672_abnormal_birth_weight1.52317351
34MP0005645_abnormal_hypothalamus_physiol1.52142408
35MP0002102_abnormal_ear_morphology1.48762898
36MP0002080_prenatal_lethality1.43087153
37MP0005451_abnormal_body_composition1.41393163
38MP0003221_abnormal_cardiomyocyte_apopto1.41156312
39MP0000358_abnormal_cell_content/1.37099866
40MP0001672_abnormal_embryogenesis/_devel1.36896268
41MP0005380_embryogenesis_phenotype1.36896268
42MP0001764_abnormal_homeostasis1.35344136
43MP0001727_abnormal_embryo_implantation1.33957648
44MP0000313_abnormal_cell_death1.27494922
45MP0002160_abnormal_reproductive_system1.25817047
46MP0001145_abnormal_male_reproductive1.24536467
47MP0000653_abnormal_sex_gland1.19740664
48MP0002084_abnormal_developmental_patter1.17583624
49MP0003984_embryonic_growth_retardation1.16853110
50MP0008057_abnormal_DNA_replication1.14079170
51MP0004185_abnormal_adipocyte_glucose1.12104886
52MP0002088_abnormal_embryonic_growth/wei1.08690425
53MP0002132_abnormal_respiratory_system1.08484010
54MP0003698_abnormal_male_reproductive1.05033154
55MP0004233_abnormal_muscle_weight1.03435724
56MP0003122_maternal_imprinting1.02654339
57MP0005220_abnormal_exocrine_pancreas1.01681895
58MP0005389_reproductive_system_phenotype1.01485570
59MP0002085_abnormal_embryonic_tissue0.99639544
60MP0005395_other_phenotype0.98714561
61MP0002139_abnormal_hepatobiliary_system0.95474459
62MP0002086_abnormal_extraembryonic_tissu0.95068525
63MP0005076_abnormal_cell_differentiation0.94751117
64MP0005332_abnormal_amino_acid0.94520283
65MP0001944_abnormal_pancreas_morphology0.93711877
66MP0003567_abnormal_fetal_cardiomyocyte0.93115681
67MP0004019_abnormal_vitamin_homeostasis0.92668910
68MP0005379_endocrine/exocrine_gland_phen0.92474164
69MP0003941_abnormal_skin_development0.90611499
70MP0002161_abnormal_fertility/fecundity0.90242256
71MP0008789_abnormal_olfactory_epithelium0.89478343
72MP0009703_decreased_birth_body0.88083846
73MP0001346_abnormal_lacrimal_gland0.86826463
74MP0005636_abnormal_mineral_homeostasis0.86621510
75MP0000647_abnormal_sebaceous_gland0.83941094
76MP0005384_cellular_phenotype0.83323384
77MP0001661_extended_life_span0.82036563
78MP0002269_muscular_atrophy0.81159144
79MP0002970_abnormal_white_adipose0.78958077
80MP0005058_abnormal_lysosome_morphology0.78462366
81MP0002837_dystrophic_cardiac_calcinosis0.78427277
82MP0000003_abnormal_adipose_tissue0.77312391
83MP0001188_hyperpigmentation0.75523403
84MP0005330_cardiomyopathy0.73381264
85MP0001919_abnormal_reproductive_system0.72709168
86MP0000013_abnormal_adipose_tissue0.72102798
87MP0005253_abnormal_eye_physiology0.70024292
88MP0003699_abnormal_female_reproductive0.69147039
89MP0009046_muscle_twitch0.68685641
90MP0003315_abnormal_perineum_morphology0.67027025
91MP0000749_muscle_degeneration0.66652770
92MP0001119_abnormal_female_reproductive0.65706620
93MP0000462_abnormal_digestive_system0.65413043
94MP0000751_myopathy0.64889530
95MP0003943_abnormal_hepatobiliary_system0.62810762
96MP0003121_genomic_imprinting0.62716980
97MP0001986_abnormal_taste_sensitivity0.62005926
98MP0003283_abnormal_digestive_organ0.61988893
99MP0002693_abnormal_pancreas_physiology0.60693175
100MP0000598_abnormal_liver_morphology0.59850089

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.72133136
2Hyperinsulinemic hypoglycemia (HP:0000825)5.07820976
3Hypoglycemic coma (HP:0001325)4.67312974
4Symptomatic seizures (HP:0011145)4.05522100
5Microvesicular hepatic steatosis (HP:0001414)3.50440947
6Increased hepatocellular lipid droplets (HP:0006565)3.46260590
7Hypokinesia (HP:0002375)3.36910407
8Lipid accumulation in hepatocytes (HP:0006561)3.32933148
9Abnormality of glycolysis (HP:0004366)3.21471783
10Increased serum pyruvate (HP:0003542)3.16343375
11Increased CSF lactate (HP:0002490)3.12000752
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.04607182
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.04607182
14Hyperglycemia (HP:0003074)2.82812701
15Increased intramyocellular lipid droplets (HP:0012240)2.82011579
16Abnormal mitochondria in muscle tissue (HP:0008316)2.81837974
17Hepatic necrosis (HP:0002605)2.81162550
18Hepatocellular necrosis (HP:0001404)2.72368148
19Unilateral renal agenesis (HP:0000122)2.71628872
20Ketoacidosis (HP:0001993)2.71218572
21Ragged-red muscle fibers (HP:0003200)2.70450651
22Abnormality of the pancreatic islet cells (HP:0006476)2.69532641
23Abnormality of endocrine pancreas physiology (HP:0012093)2.69532641
24Prominent metopic ridge (HP:0005487)2.68654549
25Acute necrotizing encephalopathy (HP:0006965)2.65668478
26Spastic diplegia (HP:0001264)2.64409733
27Mitochondrial inheritance (HP:0001427)2.63864831
28Reticulocytosis (HP:0001923)2.63547780
29Abnormal gallbladder physiology (HP:0012438)2.60248537
30Cholecystitis (HP:0001082)2.60248537
31Acute encephalopathy (HP:0006846)2.57849999
32Increased muscle lipid content (HP:0009058)2.49453820
33Increased serum lactate (HP:0002151)2.49064006
34Renal Fanconi syndrome (HP:0001994)2.46649210
35Cerebral edema (HP:0002181)2.44357833
36Lactic acidosis (HP:0003128)2.37835103
37Pancreatic islet-cell hyperplasia (HP:0004510)2.36738549
38Abnormality of alanine metabolism (HP:0010916)2.34442158
39Hyperalaninemia (HP:0003348)2.34442158
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34442158
41Shoulder girdle muscle weakness (HP:0003547)2.34087101
42Cerebral hypomyelination (HP:0006808)2.31967982
43Abnormality of the metopic suture (HP:0005556)2.31434913
44Respiratory difficulties (HP:0002880)2.30265808
45Exercise intolerance (HP:0003546)2.27657248
46CNS hypomyelination (HP:0003429)2.26636358
47Chromsome breakage (HP:0040012)2.22480620
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.20002172
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19978583
50Abnormality of reticulocytes (HP:0004312)2.18831514
51Hypomagnesemia (HP:0002917)2.15176024
52Abnormal gallbladder morphology (HP:0012437)2.13903910
53Overlapping toe (HP:0001845)2.13567032
54Abnormality of urine glucose concentration (HP:0011016)2.13183789
55Glycosuria (HP:0003076)2.13183789
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12289020
57Reduced antithrombin III activity (HP:0001976)2.10907414
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.09346091
59Progressive macrocephaly (HP:0004481)2.02113428
60Truncus arteriosus (HP:0001660)2.01605044
61Abnormality of the labia minora (HP:0012880)2.00526851
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99715905
63Abnormal protein N-linked glycosylation (HP:0012347)1.99715905
64Abnormal protein glycosylation (HP:0012346)1.99715905
65Abnormal glycosylation (HP:0012345)1.99715905
66Secondary amenorrhea (HP:0000869)1.98099004
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95948515
68Abnormal lung lobation (HP:0002101)1.95621809
69Abnormality of magnesium homeostasis (HP:0004921)1.94453771
70Type I transferrin isoform profile (HP:0003642)1.92756004
71Progressive muscle weakness (HP:0003323)1.90517541
72Hypobetalipoproteinemia (HP:0003563)1.89490569
73Abnormality of serum amino acid levels (HP:0003112)1.88183198
74Abnormality of methionine metabolism (HP:0010901)1.87290425
75Double outlet right ventricle (HP:0001719)1.87218178
76Congenital malformation of the right heart (HP:0011723)1.87218178
77Horseshoe kidney (HP:0000085)1.85490364
78Pelvic girdle muscle weakness (HP:0003749)1.85478481
79Hyperglycinemia (HP:0002154)1.84365559
80Neoplasm of the adrenal gland (HP:0100631)1.83821939
81Horizontal nystagmus (HP:0000666)1.83797552
82Cholelithiasis (HP:0001081)1.82978795
83Absent septum pellucidum (HP:0001331)1.82035711
84Abnormality of the septum pellucidum (HP:0007375)1.80347845
85Severe visual impairment (HP:0001141)1.80238276
86Hyperbilirubinemia (HP:0002904)1.80114017
87Male infertility (HP:0003251)1.79932920
88Pili torti (HP:0003777)1.78979714
89Insulin-resistant diabetes mellitus (HP:0000831)1.78331833
90Poikilocytosis (HP:0004447)1.77379078
91CNS demyelination (HP:0007305)1.76944725
92Tubulointerstitial nephritis (HP:0001970)1.74042337
93Abnormal hair laboratory examination (HP:0003328)1.72789526
94Increased nuchal translucency (HP:0010880)1.72061495
95Testicular atrophy (HP:0000029)1.71787721
96Abnormality of the gallbladder (HP:0005264)1.71242776
97Multiple enchondromatosis (HP:0005701)1.71213163
98Lethargy (HP:0001254)1.71068625
99Ketosis (HP:0001946)1.71001763
100Late onset (HP:0003584)1.70924079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.70734579
2PBK3.77204478
3TTK3.63708298
4EIF2AK13.36634672
5SRPK12.90063182
6TSSK62.66418393
7PDK22.45183827
8MST42.33419185
9ZAK2.25419194
10WEE12.17296133
11PLK32.14169181
12BRSK22.10926614
13NEK12.09472912
14CDC72.08870464
15MAPKAPK51.92547002
16BRSK11.91583778
17PLK11.87484348
18PLK41.77597859
19NME11.77394405
20BCKDK1.70930550
21NME21.69741028
22STK161.55582854
23STK41.52830882
24BRAF1.52024820
25TRIM281.51199794
26CCNB11.49128270
27TESK21.47102621
28EIF2AK31.46816390
29AURKA1.33668042
30AKT31.25535904
31SCYL21.22122266
32CHEK21.18399059
33MAP3K81.13879422
34PASK1.12166060
35ATR1.07621126
36AURKB1.05976900
37SIK31.03965285
38BCR1.03077156
39MAP3K41.02720948
40BRD40.98596975
41CHEK10.97748375
42STK100.93051158
43NEK20.91969610
44VRK20.91352485
45PIM20.89525852
46MAP3K50.85587032
47DYRK30.83877866
48PHKG20.80466636
49PHKG10.80466636
50ATM0.73742515
51EIF2AK20.73302547
52CSNK1G30.72180666
53RPS6KA40.69355594
54CSNK1A1L0.69216340
55PAK10.69107154
56VRK10.66703750
57MARK30.66308544
58TAOK20.66084186
59AKT20.65702007
60UHMK10.63928166
61CDK120.63016005
62CDK70.61786660
63CDK10.57509156
64MAP3K120.57392737
65STK30.56324632
66MELK0.55360946
67CSNK1G10.54159439
68CSNK2A10.53662056
69KSR10.52257814
70MST1R0.49531581
71CDK20.48167109
72ALK0.48050170
73IRAK30.47768635
74MKNK10.47585042
75BMX0.46039308
76PRKCI0.45825262
77DAPK10.45595953
78ARAF0.45521197
79MINK10.45488888
80CSNK1G20.44765488
81PLK20.44247321
82CSNK2A20.43906394
83MAP3K20.43820709
84ABL20.42468214
85CDK80.41433627
86RPS6KA50.38718717
87LATS20.38663176
88CLK10.37870337
89PAK40.37067492
90WNK30.35133250
91STK38L0.35019807
92CDK140.33901205
93RAF10.33649499
94MAPK110.31436205
95CSNK1E0.30668507
96MET0.29601385
97CDK180.29236616
98CDK90.29155952
99IRAK20.28009461
100PIM10.27404398

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.69334374
2DNA replication_Homo sapiens_hsa030302.89032232
3Mismatch repair_Homo sapiens_hsa034302.86696363
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.81697647
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.71317637
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65426203
7Non-homologous end-joining_Homo sapiens_hsa034502.32485471
8RNA transport_Homo sapiens_hsa030132.04375977
9Protein export_Homo sapiens_hsa030602.00644756
10Spliceosome_Homo sapiens_hsa030401.97592933
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96831694
12Cell cycle_Homo sapiens_hsa041101.93056078
13Base excision repair_Homo sapiens_hsa034101.92443708
14Vitamin B6 metabolism_Homo sapiens_hsa007501.80810568
15Nucleotide excision repair_Homo sapiens_hsa034201.78532989
16Homologous recombination_Homo sapiens_hsa034401.78094923
17Folate biosynthesis_Homo sapiens_hsa007901.76102046
18Carbon metabolism_Homo sapiens_hsa012001.72444010
19RNA polymerase_Homo sapiens_hsa030201.68612085
20Fatty acid elongation_Homo sapiens_hsa000621.68414290
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.65282548
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.61862101
23Pyruvate metabolism_Homo sapiens_hsa006201.61746079
24Biosynthesis of amino acids_Homo sapiens_hsa012301.61626084
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.58671528
26Oocyte meiosis_Homo sapiens_hsa041141.56210358
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52494816
28Oxidative phosphorylation_Homo sapiens_hsa001901.51998353
29Fanconi anemia pathway_Homo sapiens_hsa034601.49877118
30One carbon pool by folate_Homo sapiens_hsa006701.47430013
31Parkinsons disease_Homo sapiens_hsa050121.46865559
32Basal transcription factors_Homo sapiens_hsa030221.45988307
33Steroid biosynthesis_Homo sapiens_hsa001001.45156538
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41661244
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41383403
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37028330
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36558556
38Pyrimidine metabolism_Homo sapiens_hsa002401.35987446
39Propanoate metabolism_Homo sapiens_hsa006401.35467612
40mRNA surveillance pathway_Homo sapiens_hsa030151.31669262
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30398239
42Sulfur relay system_Homo sapiens_hsa041221.27721427
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26669050
44Sulfur metabolism_Homo sapiens_hsa009201.25957828
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.25560431
46Regulation of autophagy_Homo sapiens_hsa041401.25437997
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19987701
48RNA degradation_Homo sapiens_hsa030181.16465623
49Galactose metabolism_Homo sapiens_hsa000521.14828374
50Pentose phosphate pathway_Homo sapiens_hsa000301.12821828
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11952995
52Huntingtons disease_Homo sapiens_hsa050161.10884237
53Butanoate metabolism_Homo sapiens_hsa006501.09315195
54beta-Alanine metabolism_Homo sapiens_hsa004101.06322304
55Arginine biosynthesis_Homo sapiens_hsa002201.03897997
56Glutathione metabolism_Homo sapiens_hsa004801.01779944
57N-Glycan biosynthesis_Homo sapiens_hsa005101.00451764
58Purine metabolism_Homo sapiens_hsa002300.99369477
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97301097
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96956266
61Arginine and proline metabolism_Homo sapiens_hsa003300.95839741
62Ribosome_Homo sapiens_hsa030100.93537242
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85726187
64p53 signaling pathway_Homo sapiens_hsa041150.78622386
65Peroxisome_Homo sapiens_hsa041460.77926342
66Fatty acid metabolism_Homo sapiens_hsa012120.77872812
67Selenocompound metabolism_Homo sapiens_hsa004500.76949231
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74156582
69Metabolic pathways_Homo sapiens_hsa011000.73893962
70Fructose and mannose metabolism_Homo sapiens_hsa000510.69719968
71Alzheimers disease_Homo sapiens_hsa050100.66415092
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65838579
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64490264
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60847167
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.57819421
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50264435
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49191203
78Legionellosis_Homo sapiens_hsa051340.48363269
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47280785
80Vibrio cholerae infection_Homo sapiens_hsa051100.46757008
81Collecting duct acid secretion_Homo sapiens_hsa049660.46060048
82Phenylalanine metabolism_Homo sapiens_hsa003600.45936896
83Sphingolipid metabolism_Homo sapiens_hsa006000.38240534
84AMPK signaling pathway_Homo sapiens_hsa041520.32533886
85Insulin secretion_Homo sapiens_hsa049110.29175216
86Fatty acid degradation_Homo sapiens_hsa000710.25129307
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24717146
88Starch and sucrose metabolism_Homo sapiens_hsa005000.24144089
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21626811
90mTOR signaling pathway_Homo sapiens_hsa041500.20290678
91TGF-beta signaling pathway_Homo sapiens_hsa043500.19095038
92Glucagon signaling pathway_Homo sapiens_hsa049220.18798321
93Epstein-Barr virus infection_Homo sapiens_hsa051690.18495578
94Tyrosine metabolism_Homo sapiens_hsa003500.18132962
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18094175
96Cardiac muscle contraction_Homo sapiens_hsa042600.16210258
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15574879
98Lysine degradation_Homo sapiens_hsa003100.14670562
99Synaptic vesicle cycle_Homo sapiens_hsa047210.14005717
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11709207

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