GDPGP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.40209914
2water-soluble vitamin biosynthetic process (GO:0042364)5.94034946
3monoubiquitinated protein deubiquitination (GO:0035520)5.52124397
4sulfation (GO:0051923)4.73035281
5protein complex biogenesis (GO:0070271)4.60325111
6serotonin metabolic process (GO:0042428)4.54552090
7kinetochore assembly (GO:0051382)4.42540043
8indolalkylamine metabolic process (GO:0006586)4.26048585
9kinetochore organization (GO:0051383)4.24080352
10primary amino compound metabolic process (GO:1901160)4.23436165
11DNA replication checkpoint (GO:0000076)4.16254949
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14732886
13positive regulation of fatty acid beta-oxidation (GO:0032000)4.13865083
14mitochondrial respiratory chain complex assembly (GO:0033108)4.10688413
15mitochondrial respiratory chain complex I assembly (GO:0032981)4.02135660
16NADH dehydrogenase complex assembly (GO:0010257)4.02135660
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02135660
18negative regulation of membrane potential (GO:0045837)3.97049502
19gamma-aminobutyric acid transport (GO:0015812)3.91448436
20CENP-A containing nucleosome assembly (GO:0034080)3.90952305
21telomere maintenance via semi-conservative replication (GO:0032201)3.86717414
22negative regulation of systemic arterial blood pressure (GO:0003085)3.85950194
23proteasome assembly (GO:0043248)3.83086853
24chromatin remodeling at centromere (GO:0031055)3.82576604
25regulation of nuclear cell cycle DNA replication (GO:0033262)3.82345226
26microtubule depolymerization (GO:0007019)3.79451931
27purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.75969209
283-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.75969209
29positive regulation of fatty acid oxidation (GO:0046321)3.74720378
30DNA replication initiation (GO:0006270)3.68207654
31cell proliferation in forebrain (GO:0021846)3.66719809
32mature B cell differentiation involved in immune response (GO:0002313)3.65120859
33magnesium ion transport (GO:0015693)3.60765904
34DNA deamination (GO:0045006)3.58046256
35negative regulation of transcription regulatory region DNA binding (GO:2000678)3.56573671
36indole-containing compound metabolic process (GO:0042430)3.54795177
37kynurenine metabolic process (GO:0070189)3.53829764
38negative regulation of response to food (GO:0032096)3.53499348
39negative regulation of appetite (GO:0032099)3.53499348
40protein K48-linked deubiquitination (GO:0071108)3.53341690
41indolalkylamine catabolic process (GO:0046218)3.50143143
42tryptophan catabolic process (GO:0006569)3.50143143
43indole-containing compound catabolic process (GO:0042436)3.50143143
44mitotic metaphase plate congression (GO:0007080)3.48526462
45membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.46145360
46telomere maintenance via recombination (GO:0000722)3.43683560
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40337668
48polyketide metabolic process (GO:0030638)3.36926579
49doxorubicin metabolic process (GO:0044598)3.36926579
50daunorubicin metabolic process (GO:0044597)3.36926579
51negative regulation of meiosis (GO:0045835)3.35027870
52protein K6-linked ubiquitination (GO:0085020)3.34574510
53DNA strand elongation involved in DNA replication (GO:0006271)3.32747481
54germinal center formation (GO:0002467)3.30568856
55DNA catabolic process, exonucleolytic (GO:0000738)3.30405008
56maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28987966
57negative regulation of DNA-dependent DNA replication (GO:2000104)3.28715173
58mature B cell differentiation (GO:0002335)3.26819170
59mesenchymal cell differentiation involved in kidney development (GO:0072161)3.24603870
60mesenchymal cell differentiation involved in renal system development (GO:2001012)3.24603870
61DNA strand elongation (GO:0022616)3.24315468
62protein polyglutamylation (GO:0018095)3.23496508
63ribosomal small subunit assembly (GO:0000028)3.21499894
64metaphase plate congression (GO:0051310)3.20258499
65telomere maintenance via telomere lengthening (GO:0010833)3.19224844
66protein import into peroxisome matrix (GO:0016558)3.18799198
67pharyngeal system development (GO:0060037)3.17932809
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.17864701
69mitotic recombination (GO:0006312)3.17595364
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17199416
71cellular response to ATP (GO:0071318)3.15829759
72inner cell mass cell proliferation (GO:0001833)3.14106935
73DNA replication-independent nucleosome assembly (GO:0006336)3.13846999
74DNA replication-independent nucleosome organization (GO:0034724)3.13846999
75membrane repolarization during action potential (GO:0086011)3.13319613
76DNA strand renaturation (GO:0000733)3.10877841
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.10825132
78termination of RNA polymerase III transcription (GO:0006386)3.10825132
79positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.10626569
80adaptation of signaling pathway (GO:0023058)3.10335172
81cellular anion homeostasis (GO:0030002)3.08124493
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06544612
83DNA double-strand break processing (GO:0000729)3.06010429
84deoxyribonucleotide biosynthetic process (GO:0009263)3.01828340
85DNA ligation (GO:0006266)3.00786502
86cytochrome complex assembly (GO:0017004)2.99958755
87histone exchange (GO:0043486)2.99267981
88positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.99116678
89tryptophan metabolic process (GO:0006568)2.98614165
90replication fork processing (GO:0031297)2.98610458
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.97331228
92regulation of mesoderm development (GO:2000380)2.97169589
93maturation of SSU-rRNA (GO:0030490)2.94227902
94spinal cord motor neuron differentiation (GO:0021522)2.93994174
95establishment of chromosome localization (GO:0051303)2.91431122
96nucleotide-excision repair, DNA gap filling (GO:0006297)2.91176844
97intra-S DNA damage checkpoint (GO:0031573)2.90621905
98pseudouridine synthesis (GO:0001522)2.89379201
99regulation of fatty acid beta-oxidation (GO:0031998)2.89368860
100dendritic spine morphogenesis (GO:0060997)2.88089627
101regulation of posttranscriptional gene silencing (GO:0060147)2.86036912
102regulation of gene silencing by miRNA (GO:0060964)2.86036912
103regulation of gene silencing by RNA (GO:0060966)2.86036912
104regulation of action potential (GO:0098900)2.84248729
105kidney morphogenesis (GO:0060993)2.84004417
106L-fucose catabolic process (GO:0042355)2.83682705
107fucose catabolic process (GO:0019317)2.83682705
108L-fucose metabolic process (GO:0042354)2.83682705
109transmission of nerve impulse (GO:0019226)2.82493925
110rRNA modification (GO:0000154)2.82493219
111termination of RNA polymerase I transcription (GO:0006363)2.82383389
112somite development (GO:0061053)2.82294060
113pyrimidine nucleotide catabolic process (GO:0006244)2.82064642
114regulation of DNA endoreduplication (GO:0032875)2.82032746
115regulation of glomerulus development (GO:0090192)2.80711102
116vitamin biosynthetic process (GO:0009110)2.80312708
117neuronal action potential (GO:0019228)2.80070805
118base-excision repair, AP site formation (GO:0006285)2.79174202
119dentate gyrus development (GO:0021542)2.78544131
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.77752855
121somatic hypermutation of immunoglobulin genes (GO:0016446)2.77113431
122somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77113431
123DNA synthesis involved in DNA repair (GO:0000731)2.76811875
124B cell mediated immunity (GO:0019724)2.75845466
125regulation of mitochondrial translation (GO:0070129)2.75766048
126transcription from RNA polymerase I promoter (GO:0006360)2.74454178
127positive regulation of endothelial cell differentiation (GO:0045603)2.74418533
128DNA replication-dependent nucleosome assembly (GO:0006335)2.73988210
129DNA replication-dependent nucleosome organization (GO:0034723)2.73988210
130meiotic chromosome segregation (GO:0045132)2.73239374
131aromatic amino acid family metabolic process (GO:0009072)2.71789495
132ribosome biogenesis (GO:0042254)2.71585804
133epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71477972
134tooth mineralization (GO:0034505)2.70348013
135tRNA methylation (GO:0030488)2.69843642
136membrane depolarization during action potential (GO:0086010)2.68267012
137attachment of spindle microtubules to kinetochore (GO:0008608)2.68109416
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.67994564
139reflex (GO:0060004)2.66334007
140transcription-coupled nucleotide-excision repair (GO:0006283)2.64965964
141IMP biosynthetic process (GO:0006188)2.64350856
142parturition (GO:0007567)2.64202265
143rRNA processing (GO:0006364)2.63191475
144regulation of endothelial cell differentiation (GO:0045601)2.63131695
145negative regulation of synaptic transmission, GABAergic (GO:0032229)2.62444859
146positive regulation of fatty acid transport (GO:2000193)2.62259395
147DNA replication (GO:0006260)2.62256272
148spliceosomal snRNP assembly (GO:0000387)2.62196385
149regulation of sequestering of triglyceride (GO:0010889)2.62008357
150regulation of hippo signaling (GO:0035330)2.61663451
151cellular response to exogenous dsRNA (GO:0071360)2.61450245
152detection of light stimulus involved in sensory perception (GO:0050962)2.61305933
153detection of light stimulus involved in visual perception (GO:0050908)2.61305933
154establishment of integrated proviral latency (GO:0075713)2.60372896
155deoxyribose phosphate biosynthetic process (GO:0046385)2.60345582
1562-deoxyribonucleotide biosynthetic process (GO:0009265)2.60345582
157transcription initiation from RNA polymerase I promoter (GO:0006361)2.59714456
158negative regulation of hormone biosynthetic process (GO:0032353)2.59368363
1597-methylguanosine mRNA capping (GO:0006370)2.59121824
160B cell activation involved in immune response (GO:0002312)2.59093259
161RNA capping (GO:0036260)2.58736208
1627-methylguanosine RNA capping (GO:0009452)2.58736208
163regulation of neurotransmitter uptake (GO:0051580)2.58222408
164immunoglobulin mediated immune response (GO:0016064)2.58175802
165platelet dense granule organization (GO:0060155)2.58003369
166energy homeostasis (GO:0097009)2.57108718
167tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.56733816
168RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.56733816
169DNA-dependent DNA replication (GO:0006261)2.56727933
170rRNA methylation (GO:0031167)2.56629991
171positive regulation of DNA-dependent DNA replication (GO:2000105)2.55659064
172ribonucleoprotein complex biogenesis (GO:0022613)2.55355270
173regulation of histone H3-K9 methylation (GO:0051570)2.55217585
174positive regulation of cardiac muscle cell differentiation (GO:2000727)2.54837181
175misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.53740675
176aromatic amino acid family catabolic process (GO:0009074)2.53409200
177negative regulation of blood pressure (GO:0045776)2.53276818
178rRNA metabolic process (GO:0016072)2.52982140
179ovulation cycle (GO:0042698)2.52039711
180mismatch repair (GO:0006298)2.51286720
181negative regulation of mast cell activation (GO:0033004)2.50972060
182nucleobase biosynthetic process (GO:0046112)2.50859688
183limb development (GO:0060173)2.48624464
184appendage development (GO:0048736)2.48624464
185telomere maintenance (GO:0000723)2.48347599
186telomere organization (GO:0032200)2.48181158
187regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47712702
188regulation of mitotic spindle checkpoint (GO:1903504)2.47712702
189positive regulation of potassium ion transmembrane transport (GO:1901381)2.46039297
190amino sugar catabolic process (GO:0046348)2.45247127
191regulation of secondary heart field cardioblast proliferation (GO:0003266)2.44475014
192regulation of cardioblast proliferation (GO:0003264)2.44475014
193axoneme assembly (GO:0035082)2.44422859
194exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43805592
195negative regulation of telomere maintenance (GO:0032205)2.43687552
196regulation of membrane repolarization (GO:0060306)2.43604136
197photoreceptor cell development (GO:0042461)2.43312378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.01940178
2EZH2_22144423_ChIP-Seq_EOC_Human4.54604165
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.49255835
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63087809
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32289641
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.22776321
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.22010467
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.04870346
9ZNF274_21170338_ChIP-Seq_K562_Hela2.86102645
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.82768007
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.76494997
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.73004717
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60833045
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51452643
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.49837157
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.49024221
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.42170859
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41737160
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.40084962
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34610375
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31278017
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30393637
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.27260037
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26418149
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.21911617
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21544212
27FOXP3_21729870_ChIP-Seq_TREG_Human2.18160104
28VDR_23849224_ChIP-Seq_CD4+_Human2.14963685
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14410436
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08219053
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07839324
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02912054
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.00267014
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99249765
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.92979605
36ELK1_19687146_ChIP-ChIP_HELA_Human1.91719562
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90711540
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89992396
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84485440
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84291864
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.82674166
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78518717
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76677984
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.75909136
45IRF1_19129219_ChIP-ChIP_H3396_Human1.75684157
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75452501
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74840742
48TAF15_26573619_Chip-Seq_HEK293_Human1.74554719
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.74295148
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.73945261
51REST_21632747_ChIP-Seq_MESCs_Mouse1.72421623
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70477110
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67581953
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66865631
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65303539
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64766519
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.64546501
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.63883604
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62242094
60P300_19829295_ChIP-Seq_ESCs_Human1.60548730
61MYC_18940864_ChIP-ChIP_HL60_Human1.60222346
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59904648
63SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.58115024
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56416681
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.56053871
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.56044051
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55300811
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54411384
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49908960
70TTF2_22483619_ChIP-Seq_HELA_Human1.48697956
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47571159
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47568993
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46386777
74SUZ12_27294783_Chip-Seq_ESCs_Mouse1.45302601
75ER_23166858_ChIP-Seq_MCF-7_Human1.44111141
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44093735
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43908024
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43676424
79DCP1A_22483619_ChIP-Seq_HELA_Human1.43446177
80IGF1R_20145208_ChIP-Seq_DFB_Human1.42360563
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41745901
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.41628147
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.41569179
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40885063
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40335906
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39676206
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38420482
88CBP_20019798_ChIP-Seq_JUKART_Human1.38420482
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37120477
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37040979
91BCAT_22108803_ChIP-Seq_LS180_Human1.36231739
92RNF2_27304074_Chip-Seq_NSC_Mouse1.35718427
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33774094
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32389818
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32276439
96STAT3_23295773_ChIP-Seq_U87_Human1.31987027
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30991590
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30703031
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29796887
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29732699
101NCOR_22424771_ChIP-Seq_293T_Human1.28522430
102GABP_19822575_ChIP-Seq_HepG2_Human1.26889256
103ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25177757
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25057811
105SMAD4_21799915_ChIP-Seq_A2780_Human1.23912536
106CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23496709
107XRN2_22483619_ChIP-Seq_HELA_Human1.23297862
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.22839810
109CIITA_25753668_ChIP-Seq_RAJI_Human1.22278383
110RNF2_27304074_Chip-Seq_ESCs_Mouse1.22273072
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21537285
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20317587
113TCF4_23295773_ChIP-Seq_U87_Human1.18911388
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18524418
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18524418
116AR_25329375_ChIP-Seq_VCAP_Human1.18358290
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.18338481
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17555735
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17480624
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17480624
121NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17441727
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.16305047
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16176509
124SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14511530
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13625422
126AR_21909140_ChIP-Seq_LNCAP_Human1.13445286
127VDR_22108803_ChIP-Seq_LS180_Human1.13071101
128FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12252874
129FOXA1_25329375_ChIP-Seq_VCAP_Human1.12252874
130KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11607476
131KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11607476
132KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11607476
133SMAD3_21741376_ChIP-Seq_EPCs_Human1.11416359
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10612678
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09392090
136SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09022680
137ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08689838
138TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08047597
139RXR_22108803_ChIP-Seq_LS180_Human1.07167839
140TP53_22573176_ChIP-Seq_HFKS_Human1.06868227
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06677078
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.05488672
143SPI1_23547873_ChIP-Seq_NB4_Human1.05261410
144MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05167442
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04755289
146PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02759567
147SOX2_19829295_ChIP-Seq_ESCs_Human1.02128844
148NANOG_19829295_ChIP-Seq_ESCs_Human1.02128844
149KAP1_22055183_ChIP-Seq_ESCs_Mouse1.00863258
150IRF8_21731497_ChIP-ChIP_J774_Mouse1.00729198
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00330809
152HOXB7_26014856_ChIP-Seq_BT474_Human1.00121698
153PRDM14_20953172_ChIP-Seq_ESCs_Human1.00062358
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99815260
155EWS_26573619_Chip-Seq_HEK293_Human0.99673927
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.99498205
157TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98947629
158EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98907112
159REST_18959480_ChIP-ChIP_MESCs_Mouse0.98490185
160ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98399297
161OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97918533
162FLI1_21867929_ChIP-Seq_TH2_Mouse0.97497024
163GBX2_23144817_ChIP-Seq_PC3_Human0.97260994
164TP53_16413492_ChIP-PET_HCT116_Human0.96493994
165CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96134054
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.94553724
167P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92628749
168TCF4_22108803_ChIP-Seq_LS180_Human0.92578371
169POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90708956
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90681891
171BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90624571
172PCGF2_27294783_Chip-Seq_NPCs_Mouse0.84006686
173NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83458587
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82373496
175IRF8_22096565_ChIP-ChIP_GC-B_Human0.81823356
176MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81659547
177RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80548380
178SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78837818
179EZH2_27294783_Chip-Seq_NPCs_Mouse0.78055527
180FUS_26573619_Chip-Seq_HEK293_Human0.77751112
181STAT3_18555785_Chip-Seq_ESCs_Mouse0.76642921
182SUZ12_18555785_Chip-Seq_ESCs_Mouse0.75728676
183SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74495833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.42241669
2MP0002837_dystrophic_cardiac_calcinosis4.46592128
3MP0006292_abnormal_olfactory_placode3.91049134
4MP0003693_abnormal_embryo_hatching3.83862054
5MP0010094_abnormal_chromosome_stability3.83238871
6MP0008058_abnormal_DNA_repair3.65272378
7MP0003111_abnormal_nucleus_morphology3.52448635
8MP0008057_abnormal_DNA_replication3.08435333
9MP0001968_abnormal_touch/_nociception2.69006282
10MP0003077_abnormal_cell_cycle2.65164054
11MP0008877_abnormal_DNA_methylation2.56448830
12MP0002736_abnormal_nociception_after2.51492357
13MP0001188_hyperpigmentation2.46302856
14MP0002396_abnormal_hematopoietic_system2.42529293
15MP0004957_abnormal_blastocyst_morpholog2.33614251
16MP0001986_abnormal_taste_sensitivity2.30991906
17MP0004130_abnormal_muscle_cell2.28044227
18MP0001485_abnormal_pinna_reflex2.27397525
19MP0005075_abnormal_melanosome_morpholog2.27337117
20MP0003195_calcinosis2.26439019
21MP0002132_abnormal_respiratory_system2.19163610
22MP0009697_abnormal_copulation2.18572837
23MP0003718_maternal_effect2.14275814
24MP0003011_delayed_dark_adaptation2.09992340
25MP0000490_abnormal_crypts_of2.02351123
26MP0004145_abnormal_muscle_electrophysio1.98934826
27MP0009046_muscle_twitch1.95627690
28MP0005646_abnormal_pituitary_gland1.95220825
29MP0002638_abnormal_pupillary_reflex1.89741515
30MP0003787_abnormal_imprinting1.87188735
31MP0005671_abnormal_response_to1.86325422
32MP0003122_maternal_imprinting1.84560797
33MP0005551_abnormal_eye_electrophysiolog1.82314237
34MP0004742_abnormal_vestibular_system1.82295624
35MP0004885_abnormal_endolymph1.79774314
36MP0008932_abnormal_embryonic_tissue1.78716528
37MP0008007_abnormal_cellular_replicative1.77813376
38MP0000631_abnormal_neuroendocrine_gland1.75510462
39MP0002272_abnormal_nervous_system1.75308561
40MP0001835_abnormal_antigen_presentation1.74046297
41MP0008872_abnormal_physiological_respon1.73853825
42MP0009745_abnormal_behavioral_response1.72130515
43MP0003786_premature_aging1.68356394
44MP0002277_abnormal_respiratory_mucosa1.64649447
45MP0008775_abnormal_heart_ventricle1.64577877
46MP0000049_abnormal_middle_ear1.62123458
47MP0004142_abnormal_muscle_tone1.61386642
48MP0000569_abnormal_digit_pigmentation1.57145857
49MP0006072_abnormal_retinal_apoptosis1.56907358
50MP0001905_abnormal_dopamine_level1.54900928
51MP0002938_white_spotting1.53581282
52MP0001486_abnormal_startle_reflex1.48601974
53MP0000015_abnormal_ear_pigmentation1.48537083
54MP0003763_abnormal_thymus_physiology1.48450840
55MP0003941_abnormal_skin_development1.47722530
56MP0005174_abnormal_tail_pigmentation1.46340959
57MP0002928_abnormal_bile_duct1.42724951
58MP0001800_abnormal_humoral_immune1.41643234
59MP0004133_heterotaxia1.40819703
60MP0002064_seizures1.40592552
61MP0002733_abnormal_thermal_nociception1.39648034
62MP0009333_abnormal_splenocyte_physiolog1.39604144
63MP0002160_abnormal_reproductive_system1.37726858
64MP0001970_abnormal_pain_threshold1.34227517
65MP0009785_altered_susceptibility_to1.33262017
66MP0002102_abnormal_ear_morphology1.31794344
67MP0005389_reproductive_system_phenotype1.31455378
68MP0001440_abnormal_grooming_behavior1.29758432
69MP0005451_abnormal_body_composition1.28776891
70MP0003890_abnormal_embryonic-extraembry1.26869917
71MP0002398_abnormal_bone_marrow1.26163452
72MP0005377_hearing/vestibular/ear_phenot1.26094301
73MP0003878_abnormal_ear_physiology1.26094301
74MP0002557_abnormal_social/conspecific_i1.24102166
75MP0005379_endocrine/exocrine_gland_phen1.23254088
76MP0002210_abnormal_sex_determination1.22277322
77MP0002572_abnormal_emotion/affect_behav1.21187382
78MP0000026_abnormal_inner_ear1.20288501
79MP0000230_abnormal_systemic_arterial1.19431342
80MP0002735_abnormal_chemical_nociception1.16866090
81MP0005670_abnormal_white_adipose1.16518238
82MP0002163_abnormal_gland_morphology1.16136874
83MP0004924_abnormal_behavior1.15177501
84MP0005386_behavior/neurological_phenoty1.15177501
85MP0002420_abnormal_adaptive_immunity1.13910831
86MP0002452_abnormal_antigen_presenting1.13517982
87MP0005409_darkened_coat_color1.12780446
88MP0002723_abnormal_immune_serum1.12315286
89MP0003136_yellow_coat_color1.12292872
90MP0008875_abnormal_xenobiotic_pharmacok1.11510474
91MP0001819_abnormal_immune_cell1.11261703
92MP0009384_cardiac_valve_regurgitation1.11005000
93MP0002734_abnormal_mechanical_nocicepti1.10817173
94MP0001963_abnormal_hearing_physiology1.09613038
95MP0002095_abnormal_skin_pigmentation1.09571716
96MP0002653_abnormal_ependyma_morphology1.09057736
97MP0003724_increased_susceptibility_to1.08855602
98MP0003123_paternal_imprinting1.08733573
99MP0009250_abnormal_appendicular_skeleto1.08165213
100MP0001919_abnormal_reproductive_system1.08149059
101MP0002722_abnormal_immune_system1.07443141
102MP0000689_abnormal_spleen_morphology1.05476351
103MP0001119_abnormal_female_reproductive1.05471658
104MP0002067_abnormal_sensory_capabilities1.05325563
105MP0005000_abnormal_immune_tolerance1.03501411
106MP0005310_abnormal_salivary_gland1.03144559
107MP0005253_abnormal_eye_physiology1.03046592
108MP0006276_abnormal_autonomic_nervous1.02878253
109MP0000350_abnormal_cell_proliferation1.02355151
110MP0003880_abnormal_central_pattern1.02290146
111MP0004215_abnormal_myocardial_fiber1.01344288
112MP0000566_synostosis1.01137090
113MP0005387_immune_system_phenotype1.00456570
114MP0001790_abnormal_immune_system1.00456570
115MP0001873_stomach_inflammation1.00004815
116MP0003937_abnormal_limbs/digits/tail_de0.99219801
117MP0000703_abnormal_thymus_morphology0.99000632
118MP0005084_abnormal_gallbladder_morpholo0.98242865
119MP0002148_abnormal_hypersensitivity_rea0.98160539
120MP0005025_abnormal_response_to0.97366986
121MP0000716_abnormal_immune_system0.96437736
122MP0010386_abnormal_urinary_bladder0.96123335
123MP0002419_abnormal_innate_immunity0.95787896
124MP0003938_abnormal_ear_development0.94595487
125MP0000470_abnormal_stomach_morphology0.94449454
126MP0004134_abnormal_chest_morphology0.94245881
127MP0010307_abnormal_tumor_latency0.93863445
128MP0003635_abnormal_synaptic_transmissio0.93079598
129MP0003638_abnormal_response/metabolism_0.92586045
130MP0001145_abnormal_male_reproductive0.92333123
131MP0001853_heart_inflammation0.92015444
132MP0001186_pigmentation_phenotype0.91129575
133MP0002429_abnormal_blood_cell0.90622700
134MP0000653_abnormal_sex_gland0.90181591
135MP0002019_abnormal_tumor_incidence0.89818684
136MP0003186_abnormal_redox_activity0.89254567
137MP0003121_genomic_imprinting0.88932505
138MP0003183_abnormal_peptide_metabolism0.88733482
139MP0005332_abnormal_amino_acid0.88707615
140MP0002138_abnormal_hepatobiliary_system0.88670347
141MP0000313_abnormal_cell_death0.88613898
142MP0002075_abnormal_coat/hair_pigmentati0.88588048
143MP0008789_abnormal_olfactory_epithelium0.87878522
144MP0008995_early_reproductive_senescence0.87543560
145MP0000538_abnormal_urinary_bladder0.85817149
146MP0004085_abnormal_heartbeat0.85558967
147MP0003879_abnormal_hair_cell0.84031181
148MP0002752_abnormal_somatic_nervous0.83932407
149MP0002063_abnormal_learning/memory/cond0.83715423
150MP0001929_abnormal_gametogenesis0.83431674
151MP0000372_irregular_coat_pigmentation0.82510408
152MP0003942_abnormal_urinary_system0.82212534
153MP0003119_abnormal_digestive_system0.81799944
154MP0003283_abnormal_digestive_organ0.81482958
155MP0005195_abnormal_posterior_eye0.79479464
156MP0003633_abnormal_nervous_system0.79224341
157MP0004808_abnormal_hematopoietic_stem0.77535070
158MP0000427_abnormal_hair_cycle0.77006201
159MP0003137_abnormal_impulse_conducting0.76945883
160MP0005410_abnormal_fertilization0.76662068
161MP0009379_abnormal_foot_pigmentation0.75915934
162MP0000858_altered_metastatic_potential0.75683502
163MP0000537_abnormal_urethra_morphology0.74730936
164MP0010155_abnormal_intestine_physiology0.74511632
165MP0002184_abnormal_innervation0.73151709
166MP0002876_abnormal_thyroid_physiology0.72601839
167MP0000371_diluted_coat_color0.71295187
168MP0001502_abnormal_circadian_rhythm0.71197635
169MP0001756_abnormal_urination0.71132234
170MP0001764_abnormal_homeostasis0.70908693
171MP0005448_abnormal_energy_balance0.70456989
172MP0003866_abnormal_defecation0.69491290
173MP0005645_abnormal_hypothalamus_physiol0.67142245
174MP0000465_gastrointestinal_hemorrhage0.67020096
175MP0005499_abnormal_olfactory_system0.65090748
176MP0005394_taste/olfaction_phenotype0.65090748

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.95482836
2Chromsome breakage (HP:0040012)6.60723463
3Cutaneous melanoma (HP:0012056)5.42723895
4Birth length less than 3rd percentile (HP:0003561)4.67544922
5Aplastic anemia (HP:0001915)4.59946468
6Meningioma (HP:0002858)3.93393364
7Methylmalonic acidemia (HP:0002912)3.89429225
8Pancreatic cysts (HP:0001737)3.88294770
9Abnormality of chromosome stability (HP:0003220)3.82017979
10Abnormality of the preputium (HP:0100587)3.73561385
11Methylmalonic aciduria (HP:0012120)3.68080874
12Genetic anticipation (HP:0003743)3.60437636
13Meckel diverticulum (HP:0002245)3.55691813
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.53219368
15True hermaphroditism (HP:0010459)3.49745678
16Abnormality of the ileum (HP:0001549)3.43377542
17Reticulocytopenia (HP:0001896)3.38522181
18Microvesicular hepatic steatosis (HP:0001414)3.28151629
19Congenital stationary night blindness (HP:0007642)3.24895866
20Progressive cerebellar ataxia (HP:0002073)3.24825981
21Duplicated collecting system (HP:0000081)3.23383492
22Abolished electroretinogram (ERG) (HP:0000550)3.19081058
23Nephronophthisis (HP:0000090)3.16140929
24Abnormality of midbrain morphology (HP:0002418)3.10700601
25Molar tooth sign on MRI (HP:0002419)3.10700601
26Nephroblastoma (Wilms tumor) (HP:0002667)3.09877287
27Clubbing of toes (HP:0100760)3.05175560
28Pendular nystagmus (HP:0012043)3.01051202
29Absent thumb (HP:0009777)2.98637938
30Prostate neoplasm (HP:0100787)2.93131856
31Hyperglycinemia (HP:0002154)2.93081269
32Abnormality of the renal collecting system (HP:0004742)2.87769832
33Embryonal renal neoplasm (HP:0011794)2.85478108
343-Methylglutaconic aciduria (HP:0003535)2.83964868
35Duodenal stenosis (HP:0100867)2.82698272
36Small intestinal stenosis (HP:0012848)2.82698272
37Short femoral neck (HP:0100864)2.76123630
38Breast hypoplasia (HP:0003187)2.75502409
39Congenital sensorineural hearing impairment (HP:0008527)2.62018781
40Bone marrow hypocellularity (HP:0005528)2.61985819
41Cystic liver disease (HP:0006706)2.61900702
42Furrowed tongue (HP:0000221)2.61698740
43Myelodysplasia (HP:0002863)2.60906338
44Agitation (HP:0000713)2.59882392
45Abnormality of the renal medulla (HP:0100957)2.59827410
46Decreased circulating renin level (HP:0003351)2.58041282
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.56122550
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.55529495
49Absent/shortened dynein arms (HP:0200106)2.55529495
50Abnormality of the carotid arteries (HP:0005344)2.53960605
51Abnormality of the duodenum (HP:0002246)2.50422082
52Fibular aplasia (HP:0002990)2.47912914
53Ectopic kidney (HP:0000086)2.47451957
54Conjunctival hamartoma (HP:0100780)2.43840056
55Gaze-evoked nystagmus (HP:0000640)2.43166660
56Abnormality of DNA repair (HP:0003254)2.42997526
57Clumsiness (HP:0002312)2.35037826
58Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.34349862
59Hypoplasia of the uterus (HP:0000013)2.34004123
60Pancytopenia (HP:0001876)2.33927101
61Triphalangeal thumb (HP:0001199)2.33897953
62Type I transferrin isoform profile (HP:0003642)2.33680565
63Short 4th metacarpal (HP:0010044)2.31892689
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31892689
65Medulloblastoma (HP:0002885)2.31678233
66IgM deficiency (HP:0002850)2.30933990
67Chorioretinal atrophy (HP:0000533)2.30665071
68Concave nail (HP:0001598)2.30474965
69Asplenia (HP:0001746)2.28180940
70Abnormal rod and cone electroretinograms (HP:0008323)2.27876153
71Type II lissencephaly (HP:0007260)2.27620948
72Keratoconus (HP:0000563)2.26654609
73Increased corneal curvature (HP:0100692)2.26654609
74Sparse eyelashes (HP:0000653)2.25231181
75Abnormality of the proximal phalanges of the hand (HP:0009834)2.24862602
76Attenuation of retinal blood vessels (HP:0007843)2.24529249
77Anal stenosis (HP:0002025)2.24147410
78Rough bone trabeculation (HP:0100670)2.23922384
79Cheilitis (HP:0100825)2.22994719
80Aplasia/hypoplasia of the uterus (HP:0008684)2.22190030
81Decreased central vision (HP:0007663)2.22185633
82Supernumerary spleens (HP:0009799)2.22054908
83Short thumb (HP:0009778)2.20573149
84Agnosia (HP:0010524)2.19118536
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18171865
86Chronic hepatic failure (HP:0100626)2.17856204
87Abnormality of the renal cortex (HP:0011035)2.17574750
88Abnormal respiratory motile cilium morphology (HP:0005938)2.17232064
89Abnormal respiratory epithelium morphology (HP:0012253)2.17232064
90Oligohydramnios (HP:0001562)2.14386431
91Abnormality of vitamin B metabolism (HP:0004340)2.12876980
92Sclerocornea (HP:0000647)2.12060809
93Abnormality of the vitamin B12 metabolism (HP:0004341)2.11301349
94Short hallux (HP:0010109)2.11141078
95Acute lymphatic leukemia (HP:0006721)2.08988860
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06889785
97Abnormality of alanine metabolism (HP:0010916)2.06889785
98Hyperalaninemia (HP:0003348)2.06889785
99Goiter (HP:0000853)2.06098774
100Hyperventilation (HP:0002883)2.05112661
101Neoplasm of the adrenal cortex (HP:0100641)2.04485067
102Confusion (HP:0001289)2.04433005
103Renal cortical cysts (HP:0000803)2.03756464
104Medial flaring of the eyebrow (HP:0010747)2.03397246
105Patellar aplasia (HP:0006443)2.03179348
106Abnormality of the middle phalanges of the toes (HP:0010183)2.03140726
107Small hand (HP:0200055)2.02556515
108Aplasia/Hypoplasia of the spleen (HP:0010451)2.02142148
109Febrile seizures (HP:0002373)2.00861465
110Absent radius (HP:0003974)2.00770024
111Hemiparesis (HP:0001269)1.98646470
112Bone cyst (HP:0012062)1.98622467
113Aplasia/Hypoplasia of the hallux (HP:0008362)1.98519446
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.98043074
115Male pseudohermaphroditism (HP:0000037)1.97364340
116Benign neoplasm of the central nervous system (HP:0100835)1.97276224
117Horseshoe kidney (HP:0000085)1.96716439
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95569910
119Hemiplegia (HP:0002301)1.95015086
120Sloping forehead (HP:0000340)1.94757333
121Tubular atrophy (HP:0000092)1.93675832
122Hamartoma of the eye (HP:0010568)1.92705190
123Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.92641218
124Abnormal drinking behavior (HP:0030082)1.92431095
125Polydipsia (HP:0001959)1.92431095
126Pallor (HP:0000980)1.92260858
127Upper limb muscle weakness (HP:0003484)1.90978967
128Ketosis (HP:0001946)1.90815130
129Aplasia involving forearm bones (HP:0009822)1.90385028
130Absent forearm bone (HP:0003953)1.90385028
131Aplasia/Hypoplasia of the fibula (HP:0006492)1.90206332
132Hypoplasia of the ulna (HP:0003022)1.89922771
133Abnormality of the prostate (HP:0008775)1.89201388
134Large for gestational age (HP:0001520)1.86386652
135Abnormality of the columella (HP:0009929)1.85912984
136Bony spicule pigmentary retinopathy (HP:0007737)1.85725815
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84487998
138Abnormality of the 4th metacarpal (HP:0010012)1.84408766
139Pancreatic fibrosis (HP:0100732)1.84249717
140Reduced antithrombin III activity (HP:0001976)1.84156090
141Abnormality of binocular vision (HP:0011514)1.83339198
142Diplopia (HP:0000651)1.83339198
143Short tibia (HP:0005736)1.83198233
144Chronic mucocutaneous candidiasis (HP:0002728)1.82319833
145Recurrent cutaneous fungal infections (HP:0011370)1.82319833
146Irregular vertebral endplates (HP:0003301)1.81573930
147Anencephaly (HP:0002323)1.81478616
148Mesomelia (HP:0003027)1.81101895
149Aplasia/Hypoplasia of the patella (HP:0006498)1.81000836
150Type 2 muscle fiber atrophy (HP:0003554)1.80927957
151Inability to walk (HP:0002540)1.80899053
152Abnormality of the phalanges of the 5th finger (HP:0004213)1.79583939
153Aplasia/hypoplasia of the femur (HP:0005613)1.79194287
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.79144037
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.78442989
156Abnormal trabecular bone morphology (HP:0100671)1.78408982
157Asymmetry of the thorax (HP:0001555)1.78328578
158Septo-optic dysplasia (HP:0100842)1.77480393
159Mitochondrial inheritance (HP:0001427)1.76668567
160Hypergonadotropic hypogonadism (HP:0000815)1.76568966
161Fibular hypoplasia (HP:0003038)1.75906443
162Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75793180
163Abnormality of the anterior horn cell (HP:0006802)1.75776571
164Degeneration of anterior horn cells (HP:0002398)1.75776571
165Optic nerve coloboma (HP:0000588)1.75118181
166Abnormality of serine family amino acid metabolism (HP:0010894)1.73918327
167Abnormality of glycine metabolism (HP:0010895)1.73918327
168Abnormality of pyrimidine metabolism (HP:0004353)1.73607093
169Adactyly (HP:0009776)1.73109981
170Oral leukoplakia (HP:0002745)1.72904513
171Abnormal lung lobation (HP:0002101)1.71822721
172Abnormal number of erythroid precursors (HP:0012131)1.71744263
173Abnormal ciliary motility (HP:0012262)1.70896290
174Tracheoesophageal fistula (HP:0002575)1.69320050
175Long foot (HP:0001833)1.68913143
176Abnormality of cells of the erythroid lineage (HP:0012130)1.68793561
177Duplication of thumb phalanx (HP:0009942)1.68338949
178Dry hair (HP:0011359)1.68223016
179Lymphoma (HP:0002665)1.68172125
180Premature graying of hair (HP:0002216)1.68158122
181Severe visual impairment (HP:0001141)1.67889125
182Prolonged bleeding time (HP:0003010)1.67019990
183Leukopenia (HP:0001882)1.66312915
184Petechiae (HP:0000967)1.66223917
185Impulsivity (HP:0100710)1.64182473
186Congenital, generalized hypertrichosis (HP:0004540)1.63236164
187Astigmatism (HP:0000483)1.62640725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.10794232
2CDC73.40499916
3SRPK13.29698015
4STK163.16933945
5CASK2.83230216
6MKNK22.63779892
7BUB12.52791272
8CCNB12.49924511
9BMPR22.49299818
10ZAK2.36427478
11FGFR22.28279142
12VRK12.22985255
13PIK3CG2.14665589
14TXK2.13544899
15PINK12.03571272
16EIF2AK11.97140607
17WNK41.96501750
18MKNK11.92164800
19WEE11.90979959
20TTK1.84699175
21ADRBK21.77510781
22IRAK31.76801948
23AKT31.73412457
24PLK41.72886199
25TSSK61.72422869
26WNK31.71170963
27MAP3K141.69526792
28EIF2AK21.51331050
29PLK11.48442928
30TLK11.48263357
31MAP4K21.48194233
32IRAK41.44250628
33MAP2K71.43574034
34PLK31.40885498
35ATR1.40446502
36ADRBK11.28679022
37YES11.26276176
38CDK71.26194288
39GRK11.24627204
40KIT1.23074176
41CDK81.20835388
42STK391.19852637
43BCKDK1.19003212
44PRKD21.18336051
45SIK31.17067218
46BRAF1.16861598
47AURKB1.16240927
48MAP3K121.15500201
49CHEK21.15330346
50TEC1.14827252
51NTRK31.12498589
52DAPK21.11738105
53OXSR11.09580202
54MAP3K41.08667767
55BTK1.06365646
56TNIK1.05838681
57DYRK21.05302005
58NME21.03464812
59IKBKB1.03229660
60BRD41.02724523
61IKBKE1.01414152
62PRKCG1.00477933
63MAP4K10.99427629
64PAK30.97751866
65NTRK20.95129469
66TIE10.94893438
67BLK0.94428041
68PIM10.94246761
69TAF10.91408280
70BMPR1B0.88982244
71ACVR1B0.88712732
72EIF2AK30.87272864
73PHKG20.85681521
74PHKG10.85681521
75PIK3CA0.84395615
76LYN0.84375637
77NEK20.83967692
78JAK30.81299000
79CSNK1G20.80457986
80CDK30.79688322
81PASK0.78931757
82PRKCE0.78687780
83PIM20.78350777
84STK110.77944545
85AURKA0.75837647
86ERBB20.74770894
87SYK0.74188398
88SGK4940.74157833
89SGK2230.74157833
90STK40.72863891
91CSNK1G30.72361710
92NEK60.72231181
93MAPKAPK50.71086294
94CSNK1G10.70157300
95MAPK130.68544335
96TGFBR10.66298797
97PRKCQ0.66222748
98GRK60.66151613
99CHEK10.65408316
100CSNK1A1L0.64863705
101ATM0.64575495
102SGK10.63221553
103MUSK0.63127384
104CSNK2A10.63038973
105EPHB20.62691643
106CSNK2A20.62646619
107GRK50.62512995
108RPS6KA50.62315530
109PTK2B0.61804821
110MARK10.60779019
111EPHA20.59719451
112RIPK40.59686612
113PKN10.58975400
114TESK20.58741749
115MST1R0.58693590
116NUAK10.58598412
117PRKACA0.58311740
118CLK10.58159631
119CSNK1A10.58015880
120DYRK30.57391255
121MAPKAPK30.55538204
122STK240.54563901
123FLT30.54217558
124LCK0.53380887
125SIK20.50413281
126WNK10.48980978
127INSRR0.48837948
128CDK40.48810304
129PLK20.48797659
130DAPK10.48341482
131GRK70.47904112
132CAMK2A0.47852015
133TAOK20.47196418
134PRKCZ0.47027110
135MAPK150.46944624
136MAP2K60.46796475
137MAP3K70.46460140
138TAOK30.45983450
139MATK0.45476886
140VRK20.45125421
141PNCK0.44465762
142CAMKK20.44263368
143CHUK0.44198570
144OBSCN0.43844518
145NME10.43841020
146TNK20.43764158
147PRKAA20.43357409
148CDK20.43205977
149RPS6KA60.42571757
150CDK10.41153300
151STK38L0.40215023
152SGK20.39681997
153MAP3K130.39482152
154PRKCA0.39301994
155PRKCI0.37719723
156CAMK10.36915531
157NLK0.36648646
158EPHA30.34943847
159CSNK1D0.33086385
160MAP3K110.30657113
161AKT20.30541504
162TYK20.30459810
163PRKCH0.29211530
164ITK0.28971253
165MAP2K40.27757947

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91778177
2Mismatch repair_Homo sapiens_hsa034303.71313870
3Homologous recombination_Homo sapiens_hsa034403.52154219
4Fanconi anemia pathway_Homo sapiens_hsa034603.48255033
5RNA polymerase_Homo sapiens_hsa030203.24838377
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06779203
7Base excision repair_Homo sapiens_hsa034102.86293960
8Ribosome_Homo sapiens_hsa030102.82608862
9Sulfur metabolism_Homo sapiens_hsa009202.75494223
10Non-homologous end-joining_Homo sapiens_hsa034502.72528205
11Proteasome_Homo sapiens_hsa030502.50250156
12Pyrimidine metabolism_Homo sapiens_hsa002402.44444925
13One carbon pool by folate_Homo sapiens_hsa006702.39668989
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20875668
15Nucleotide excision repair_Homo sapiens_hsa034202.20443615
16Spliceosome_Homo sapiens_hsa030402.18822714
17Tryptophan metabolism_Homo sapiens_hsa003802.11200493
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.08947461
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03615450
20RNA transport_Homo sapiens_hsa030132.02020553
21Basal transcription factors_Homo sapiens_hsa030221.94944199
22Nitrogen metabolism_Homo sapiens_hsa009101.93149327
23Cell cycle_Homo sapiens_hsa041101.92472217
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73907897
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65855899
26Morphine addiction_Homo sapiens_hsa050321.63947875
27RNA degradation_Homo sapiens_hsa030181.56063389
28Cardiac muscle contraction_Homo sapiens_hsa042601.55511494
29Purine metabolism_Homo sapiens_hsa002301.54252427
30Selenocompound metabolism_Homo sapiens_hsa004501.54198830
31Retinol metabolism_Homo sapiens_hsa008301.40435712
32Caffeine metabolism_Homo sapiens_hsa002321.33799667
33Chemical carcinogenesis_Homo sapiens_hsa052041.33706046
34Butanoate metabolism_Homo sapiens_hsa006501.30109519
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29611559
36Sulfur relay system_Homo sapiens_hsa041221.29582910
37Insulin secretion_Homo sapiens_hsa049111.28559529
38Glycerolipid metabolism_Homo sapiens_hsa005611.28033448
39Serotonergic synapse_Homo sapiens_hsa047261.27165932
40Ether lipid metabolism_Homo sapiens_hsa005651.26953427
41Glutamatergic synapse_Homo sapiens_hsa047241.26648016
42Oxidative phosphorylation_Homo sapiens_hsa001901.26246692
43Primary immunodeficiency_Homo sapiens_hsa053401.26132426
44Type II diabetes mellitus_Homo sapiens_hsa049301.25471191
45Peroxisome_Homo sapiens_hsa041461.23265518
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20181517
47Circadian entrainment_Homo sapiens_hsa047131.19352840
48Phototransduction_Homo sapiens_hsa047441.18568297
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17862238
50p53 signaling pathway_Homo sapiens_hsa041151.17816545
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15468541
52Olfactory transduction_Homo sapiens_hsa047401.13918474
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10294304
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08909860
55GABAergic synapse_Homo sapiens_hsa047271.08785386
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.07993988
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06800372
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.06735781
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.04206181
60Calcium signaling pathway_Homo sapiens_hsa040200.98457577
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97878222
62Huntingtons disease_Homo sapiens_hsa050160.96391656
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.91953081
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90421931
65Allograft rejection_Homo sapiens_hsa053300.89669189
66Collecting duct acid secretion_Homo sapiens_hsa049660.89669119
67Epstein-Barr virus infection_Homo sapiens_hsa051690.87939318
68Folate biosynthesis_Homo sapiens_hsa007900.87903661
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87212191
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84180598
71Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82706225
72Other glycan degradation_Homo sapiens_hsa005110.82589779
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82407159
74Herpes simplex infection_Homo sapiens_hsa051680.82268241
75mRNA surveillance pathway_Homo sapiens_hsa030150.81444794
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.81362517
77Parkinsons disease_Homo sapiens_hsa050120.80692077
78Cholinergic synapse_Homo sapiens_hsa047250.80122675
79Measles_Homo sapiens_hsa051620.79496346
80Hematopoietic cell lineage_Homo sapiens_hsa046400.78882173
81Protein export_Homo sapiens_hsa030600.77892091
82Fatty acid biosynthesis_Homo sapiens_hsa000610.77528025
83Fat digestion and absorption_Homo sapiens_hsa049750.76251562
84ABC transporters_Homo sapiens_hsa020100.75212354
85Dopaminergic synapse_Homo sapiens_hsa047280.73602186
86Basal cell carcinoma_Homo sapiens_hsa052170.73486131
87Cocaine addiction_Homo sapiens_hsa050300.73024241
88Graft-versus-host disease_Homo sapiens_hsa053320.70651694
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70014746
90Arachidonic acid metabolism_Homo sapiens_hsa005900.69622730
91Nicotine addiction_Homo sapiens_hsa050330.68590756
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67891173
93Regulation of autophagy_Homo sapiens_hsa041400.65483193
94Systemic lupus erythematosus_Homo sapiens_hsa053220.64643815
95Salivary secretion_Homo sapiens_hsa049700.63296941
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61386749
97Renin secretion_Homo sapiens_hsa049240.60926585
98Ovarian steroidogenesis_Homo sapiens_hsa049130.60733809
99cAMP signaling pathway_Homo sapiens_hsa040240.59991635
100African trypanosomiasis_Homo sapiens_hsa051430.58456806
101Alzheimers disease_Homo sapiens_hsa050100.58163521
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56558847
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56076506
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54531672
105Linoleic acid metabolism_Homo sapiens_hsa005910.54023141
106Amphetamine addiction_Homo sapiens_hsa050310.52599055
107Gastric acid secretion_Homo sapiens_hsa049710.52265817
108Dorso-ventral axis formation_Homo sapiens_hsa043200.52115215
109Type I diabetes mellitus_Homo sapiens_hsa049400.51918772
110Histidine metabolism_Homo sapiens_hsa003400.51445886
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.51323865
112Taste transduction_Homo sapiens_hsa047420.50760429
113beta-Alanine metabolism_Homo sapiens_hsa004100.50280808
114Renin-angiotensin system_Homo sapiens_hsa046140.49892339
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49062809
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48965517
117Vitamin digestion and absorption_Homo sapiens_hsa049770.48429383
118Mineral absorption_Homo sapiens_hsa049780.47481083
119Influenza A_Homo sapiens_hsa051640.46233923
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45821373
121Vitamin B6 metabolism_Homo sapiens_hsa007500.44264362
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43489380
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43267976
124Long-term depression_Homo sapiens_hsa047300.42570211
125Hedgehog signaling pathway_Homo sapiens_hsa043400.42261295
126Oxytocin signaling pathway_Homo sapiens_hsa049210.42087059
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40633783
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.39942445
129Leishmaniasis_Homo sapiens_hsa051400.39504952
130Legionellosis_Homo sapiens_hsa051340.39101546
131Autoimmune thyroid disease_Homo sapiens_hsa053200.37741335
132Melanoma_Homo sapiens_hsa052180.36675051
133Sphingolipid metabolism_Homo sapiens_hsa006000.36218882
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.35548282
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35331699
136Fatty acid degradation_Homo sapiens_hsa000710.35043273
137Metabolic pathways_Homo sapiens_hsa011000.34861627
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34356695
139Apoptosis_Homo sapiens_hsa042100.34233847
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34157375
141Antigen processing and presentation_Homo sapiens_hsa046120.34117037
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33686775
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32663268
144T cell receptor signaling pathway_Homo sapiens_hsa046600.31965204
145Viral carcinogenesis_Homo sapiens_hsa052030.30945319
146Pentose phosphate pathway_Homo sapiens_hsa000300.29680729
147Rheumatoid arthritis_Homo sapiens_hsa053230.29094410
148Cysteine and methionine metabolism_Homo sapiens_hsa002700.28258753
149Oocyte meiosis_Homo sapiens_hsa041140.25026781
150B cell receptor signaling pathway_Homo sapiens_hsa046620.23676978
151Hepatitis B_Homo sapiens_hsa051610.23637914
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23484384
153Asthma_Homo sapiens_hsa053100.21820169
154Alcoholism_Homo sapiens_hsa050340.21453833
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20562398
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.20049150
157HTLV-I infection_Homo sapiens_hsa051660.19786517
158Inositol phosphate metabolism_Homo sapiens_hsa005620.18721210
159Acute myeloid leukemia_Homo sapiens_hsa052210.16988895
160Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15716624
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15258047

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