GDF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene are associated with Klippel-Feil syndrome, microphthalmia, and Leber congenital amaurosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of somitogenesis (GO:0014807)9.87638277
2auditory receptor cell differentiation (GO:0042491)9.35604802
3pentose metabolic process (GO:0019321)8.41929561
4endocardial cushion morphogenesis (GO:0003203)7.11474908
5protein polyglutamylation (GO:0018095)6.69789189
6inner ear receptor cell differentiation (GO:0060113)5.94208477
7glycoprotein catabolic process (GO:0006516)5.90546389
8mesenchymal cell differentiation involved in renal system development (GO:2001012)5.82853461
9mesenchymal cell differentiation involved in kidney development (GO:0072161)5.82853461
10hair cell differentiation (GO:0035315)5.78287440
11mesenchyme morphogenesis (GO:0072132)5.63059821
12wound healing, spreading of epidermal cells (GO:0035313)5.32218811
13tooth mineralization (GO:0034505)5.24533646
14atrioventricular valve morphogenesis (GO:0003181)4.86417903
15locomotory exploration behavior (GO:0035641)4.86048330
16endocrine hormone secretion (GO:0060986)4.80906199
17mechanoreceptor differentiation (GO:0042490)4.71250431
18heart valve morphogenesis (GO:0003179)4.68065823
19epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.63590586
20collagen fibril organization (GO:0030199)4.50988354
21negative regulation of homotypic cell-cell adhesion (GO:0034111)4.49511250
22cellular sodium ion homeostasis (GO:0006883)4.47205953
23regulation of hippo signaling (GO:0035330)4.26645732
24cardiac right ventricle morphogenesis (GO:0003215)4.23968209
25lymphangiogenesis (GO:0001946)4.23354159
26positive regulation of Notch signaling pathway (GO:0045747)4.17927517
27chondrocyte proliferation (GO:0035988)4.17069557
28cellular response to vitamin D (GO:0071305)4.16828584
29Notch signaling involved in heart development (GO:0061314)4.13803884
30regulation of corticosteroid hormone secretion (GO:2000846)4.07761728
31chondrocyte development (GO:0002063)4.00272456
32behavioral response to nicotine (GO:0035095)3.94417269
33cell adhesion mediated by integrin (GO:0033627)3.91685026
34collagen metabolic process (GO:0032963)3.81312766
35aorta morphogenesis (GO:0035909)3.81101335
36regulation of voltage-gated calcium channel activity (GO:1901385)3.80241569
37negative regulation of microtubule polymerization (GO:0031115)3.80031403
38substrate-dependent cell migration (GO:0006929)3.78896503
39cellular response to vitamin (GO:0071295)3.76759079
40urinary tract smooth muscle contraction (GO:0014848)3.71169967
41cardiac ventricle morphogenesis (GO:0003208)3.70952271
42type B pancreatic cell proliferation (GO:0044342)3.70899395
43gap junction assembly (GO:0016264)3.70359600
44ventricular septum morphogenesis (GO:0060412)3.69364550
45behavioral response to pain (GO:0048266)3.68346040
46collagen catabolic process (GO:0030574)3.63346089
47regulation of apoptotic process involved in morphogenesis (GO:1902337)3.62261995
48peristalsis (GO:0030432)3.61699011
49multicellular organismal macromolecule metabolic process (GO:0044259)3.57531445
50negative regulation of leukocyte chemotaxis (GO:0002689)3.57508453
51retina vasculature morphogenesis in camera-type eye (GO:0061299)3.55837533
52positive regulation of meiosis (GO:0045836)3.51833209
53outflow tract septum morphogenesis (GO:0003148)3.50909566
54protein heterotrimerization (GO:0070208)3.50240292
55bone trabecula formation (GO:0060346)3.50188086
56cardiac epithelial to mesenchymal transition (GO:0060317)3.47688485
57lipopolysaccharide biosynthetic process (GO:0009103)3.46891402
58wound healing, spreading of cells (GO:0044319)3.45435589
59cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.42839041
60negative regulation of chondrocyte differentiation (GO:0032331)3.42197904
61regulation of cardioblast proliferation (GO:0003264)3.42191015
62regulation of secondary heart field cardioblast proliferation (GO:0003266)3.42191015
63cell migration involved in gastrulation (GO:0042074)3.41807893
64cardiac chamber morphogenesis (GO:0003206)3.39282745
65dermatan sulfate biosynthetic process (GO:0030208)3.36931485
66relaxation of smooth muscle (GO:0044557)3.36908723
67multicellular organismal metabolic process (GO:0044236)3.36410332
68parturition (GO:0007567)3.35227578
69endothelium development (GO:0003158)3.35172448
70behavioral response to ethanol (GO:0048149)3.34856008
71sensory perception of sound (GO:0007605)3.32910957
72sphingosine metabolic process (GO:0006670)3.32844820
73multicellular organismal catabolic process (GO:0044243)3.31745495
74trabecula formation (GO:0060343)3.31351873
75sensory perception of mechanical stimulus (GO:0050954)3.27281190
76substrate adhesion-dependent cell spreading (GO:0034446)3.25538641
77nephron tubule development (GO:0072080)3.24811471
78regulation of glucocorticoid secretion (GO:2000849)3.22772070
79negative regulation by host of viral transcription (GO:0043922)3.21102141
80positive regulation of meiotic cell cycle (GO:0051446)3.20602773
81regulation of mesenchymal cell apoptotic process (GO:2001053)3.20348900
82sphingoid metabolic process (GO:0046519)3.19360223
83rRNA catabolic process (GO:0016075)3.18161967
84negative regulation of catecholamine secretion (GO:0033604)3.11222190
85protein localization to cell surface (GO:0034394)3.11022814
86cardiac septum morphogenesis (GO:0060411)3.10108629
87metanephric mesenchyme development (GO:0072075)3.09803135
88lens fiber cell development (GO:0070307)3.09797189
89neuroblast proliferation (GO:0007405)3.08194538
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06056620
91extracellular fibril organization (GO:0043206)3.05497901
92outer ear morphogenesis (GO:0042473)3.05144144
93positive regulation of histone deacetylation (GO:0031065)3.05135535
94smooth muscle tissue development (GO:0048745)3.04733750
95actin filament depolymerization (GO:0030042)3.04432809
96regulation of female gonad development (GO:2000194)3.03642862
97dermatan sulfate metabolic process (GO:0030205)3.03285479
98male genitalia development (GO:0030539)3.00506556
99response to gravity (GO:0009629)3.00381743
100N-glycan processing (GO:0006491)2.99669599
101mesenchymal cell development (GO:0014031)2.98662010
102regulation of heart morphogenesis (GO:2000826)2.96941829
103axon extension involved in axon guidance (GO:0048846)2.96447831
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.96447831
105diol metabolic process (GO:0034311)2.96138236
106stem cell development (GO:0048864)2.95713724
107extracellular matrix disassembly (GO:0022617)2.94698439
108actin filament bundle organization (GO:0061572)2.94190313
109actin filament bundle assembly (GO:0051017)2.94190313
110heart valve formation (GO:0003188)2.93770569
111planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92174455
112regulation of extracellular matrix disassembly (GO:0010715)2.92161048
113regulation of interleukin-8 secretion (GO:2000482)2.91205817
114positive regulation of mast cell degranulation (GO:0043306)2.90557870
115positive regulation of mast cell activation involved in immune response (GO:0033008)2.90557870
116renal tubule development (GO:0061326)2.90081114
117regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.85671903
118lipopolysaccharide metabolic process (GO:0008653)2.85355077
119drug transmembrane transport (GO:0006855)2.85259305
120endocardial cushion development (GO:0003197)2.85046703
121hippo signaling (GO:0035329)2.83761887
122negative regulation of platelet activation (GO:0010544)2.81989753
123meiotic chromosome segregation (GO:0045132)2.81816467
124regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.80164005
125basement membrane organization (GO:0071711)2.78906551
126glomerulus development (GO:0032835)2.77663615
127sequestering of extracellular ligand from receptor (GO:0035581)2.77385345
128plasma membrane repair (GO:0001778)2.76719417
129regulation of chondrocyte differentiation (GO:0032330)2.75049797
130regulation of chemokine-mediated signaling pathway (GO:0070099)2.73363046
131kidney mesenchyme development (GO:0072074)2.72090085
132epithelial to mesenchymal transition (GO:0001837)2.71698080
133nephron epithelium development (GO:0072009)2.71465700
134myoblast fusion (GO:0007520)2.71022285
135non-canonical Wnt signaling pathway (GO:0035567)2.69104787
136SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.68160549
137cell surface receptor signaling pathway involved in heart development (GO:0061311)2.67915388
138regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.67051195
139lung epithelium development (GO:0060428)2.66964088
140negative regulation of cartilage development (GO:0061037)2.66702112
141regulation of cartilage development (GO:0061035)2.66335007
142embryonic forelimb morphogenesis (GO:0035115)2.66310018
143negative regulation of axon extension involved in axon guidance (GO:0048843)2.65696049
144regulation of mesoderm development (GO:2000380)2.65489026
145histamine transport (GO:0051608)2.65042161
146positive regulation of hormone biosynthetic process (GO:0046886)2.64782425
147neuron remodeling (GO:0016322)2.64306928
148endodermal cell differentiation (GO:0035987)2.63903884
149inner ear receptor cell development (GO:0060119)2.62278929
150mesenchymal cell differentiation (GO:0048762)2.61916308
151dorsal/ventral axis specification (GO:0009950)2.61877894
152extracellular negative regulation of signal transduction (GO:1900116)2.61782560
153extracellular regulation of signal transduction (GO:1900115)2.61782560
154positive regulation of hair follicle development (GO:0051798)2.61347075
155positive regulation of hair cycle (GO:0042635)2.61347075
156peptidyl-glutamic acid modification (GO:0018200)2.60716663
157negative regulation of smooth muscle cell migration (GO:0014912)2.60330729
158regulation of plasminogen activation (GO:0010755)2.60015308
159neuronal stem cell maintenance (GO:0097150)2.58196049
160negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57762705
161regulation of steroid hormone secretion (GO:2000831)2.57403455
162cell aggregation (GO:0098743)2.57213144
163cartilage condensation (GO:0001502)2.57213144
164sprouting angiogenesis (GO:0002040)2.57083416
165cell differentiation involved in kidney development (GO:0061005)2.56968006
166neural crest cell development (GO:0014032)2.56937385
167forelimb morphogenesis (GO:0035136)2.56594328
168regulation of homotypic cell-cell adhesion (GO:0034110)2.55551338
169chondrocyte differentiation (GO:0002062)2.55329845
170heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.55160715
171regulation of platelet aggregation (GO:0090330)2.54353651
172endothelial cell morphogenesis (GO:0001886)2.52292733
173vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49425920
174endothelial cell proliferation (GO:0001935)2.47903644
175regulation of transforming growth factor beta2 production (GO:0032909)2.44970816
176connective tissue development (GO:0061448)2.44489797
177negative regulation of BMP signaling pathway (GO:0030514)2.43309377
178hindlimb morphogenesis (GO:0035137)2.43000969
179peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.42854991
180proteoglycan biosynthetic process (GO:0030166)2.42033088
181extracellular matrix organization (GO:0030198)2.41684971
182negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.41123891
183heparin metabolic process (GO:0030202)2.41021435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.16120515
2* TRIM28_21343339_ChIP-Seq_HEK293_Human5.92672010
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.88201779
4CLOCK_20551151_ChIP-Seq_293T_Human2.58485875
5GBX2_23144817_ChIP-Seq_PC3_Human2.40341336
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.37337168
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33740370
8* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33740370
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29513609
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.28398074
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.15977040
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14960467
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13107225
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04063136
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.03486108
16* EED_16625203_ChIP-ChIP_MESCs_Mouse1.97505037
17* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.91345533
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.91257934
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90197410
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.90155142
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.89049450
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.88285684
23* EP300_21415370_ChIP-Seq_HL-1_Mouse1.87698608
24* RNF2_27304074_Chip-Seq_ESCs_Mouse1.87048430
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86562451
26* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84385658
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84281788
28* EZH2_27294783_Chip-Seq_ESCs_Mouse1.83215688
29* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82714144
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79187035
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.75733514
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74374662
33* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73155076
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73150048
35ZNF274_21170338_ChIP-Seq_K562_Hela1.70828556
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.67498308
37* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64879483
38EZH2_22144423_ChIP-Seq_EOC_Human1.64601769
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63347917
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62397862
41AHR_22903824_ChIP-Seq_MCF-7_Human1.59637112
42* TP53_20018659_ChIP-ChIP_R1E_Mouse1.58095556
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57967938
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57516193
45* EZH2_27304074_Chip-Seq_ESCs_Mouse1.56647523
46* RING1B_27294783_Chip-Seq_ESCs_Mouse1.54796784
47EWS_26573619_Chip-Seq_HEK293_Human1.54773854
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.47336189
49IRF1_19129219_ChIP-ChIP_H3396_Human1.46222166
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.46210685
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46041604
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.42535785
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42439087
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.41430335
55P300_19829295_ChIP-Seq_ESCs_Human1.41192350
56KDM2B_26808549_Chip-Seq_K562_Human1.40268826
57* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38387391
58* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38325300
59SMAD3_21741376_ChIP-Seq_HESCs_Human1.36869536
60SMAD4_21799915_ChIP-Seq_A2780_Human1.36155113
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34705748
62TP53_16413492_ChIP-PET_HCT116_Human1.34578142
63* RING1B_27294783_Chip-Seq_NPCs_Mouse1.34435193
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34080313
65* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33951689
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33141758
67CJUN_26792858_Chip-Seq_BT549_Human1.31591590
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.29014167
69* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27954513
70NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27849091
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27131187
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.27098450
73DROSHA_22980978_ChIP-Seq_HELA_Human1.25783121
74TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25691244
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25116974
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24125286
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22947926
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22293259
79NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22293259
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22271564
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20017572
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.19870161
83* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17632672
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17472455
85* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17432009
86* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16943487
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.16522029
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16456529
89STAT3_23295773_ChIP-Seq_U87_Human1.14716131
90* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14121869
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.13700496
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12907961
93KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12882834
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12882834
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12882834
96* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12124828
97SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11816843
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11688957
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11537001
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.11175399
101SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.10853395
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10626922
103* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10140658
104POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09161398
105AR_21572438_ChIP-Seq_LNCaP_Human1.08676332
106SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08077918
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07707934
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.07661032
109TP53_18474530_ChIP-ChIP_U2OS_Human1.07624697
110* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05954455
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05863477
112* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05703769
113* PIAS1_25552417_ChIP-Seq_VCAP_Human1.05482106
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04753593
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04519867
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04519867
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.03670945
118TP53_23651856_ChIP-Seq_MEFs_Mouse1.03280313
119AR_25329375_ChIP-Seq_VCAP_Human1.02579814
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02241356
121EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02137677
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01306284
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.00494561
124NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00101203
125SOX2_20726797_ChIP-Seq_SW620_Human1.00061828
126JUN_21703547_ChIP-Seq_K562_Human0.99980452
127MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99835575
128SALL1_21062744_ChIP-ChIP_HESCs_Human0.99762995
129KDM2B_26808549_Chip-Seq_DND41_Human0.99560137
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99439469
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99341918
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.99322304
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98192775
134RUNX2_22187159_ChIP-Seq_PCA_Human0.97921898
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.97765229
136VDR_22108803_ChIP-Seq_LS180_Human0.96689730
137BRD4_25478319_ChIP-Seq_HGPS_Human0.96171446
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96152827
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95493382
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95379155
141KLF5_25053715_ChIP-Seq_YYC3_Human0.94561423
142RACK7_27058665_Chip-Seq_MCF-7_Human0.93972829
143* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92202185
144TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90476844
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.89820598
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.89820598
147* LXR_22292898_ChIP-Seq_THP-1_Human0.89471718
148KDM2B_26808549_Chip-Seq_JURKAT_Human0.87888878
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87474155
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86965116
151HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85490166
152NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85268786
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.85074385
154* GATA3_24758297_ChIP-Seq_MCF-7_Human0.84183566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot6.81260342
2MP0003878_abnormal_ear_physiology6.81260342
3MP0008438_abnormal_cutaneous_collagen4.53441402
4MP0001485_abnormal_pinna_reflex4.21809337
5MP0003879_abnormal_hair_cell3.63891673
6MP0003705_abnormal_hypodermis_morpholog3.53959394
7MP0003950_abnormal_plasma_membrane3.25174411
8MP0005503_abnormal_tendon_morphology2.76911660
9MP0005275_abnormal_skin_tensile2.70403517
10MP0009697_abnormal_copulation2.67679708
11MP0000026_abnormal_inner_ear2.63331190
12* MP0001963_abnormal_hearing_physiology2.52559096
13MP0005623_abnormal_meninges_morphology2.37070484
14MP0004084_abnormal_cardiac_muscle2.34536723
15MP0010386_abnormal_urinary_bladder2.34410213
16MP0004272_abnormal_basement_membrane2.30336083
17* MP0005508_abnormal_skeleton_morphology2.17029848
18MP0001958_emphysema2.08950355
19MP0000566_synostosis2.05017548
20MP0003115_abnormal_respiratory_system1.97005376
21MP0009780_abnormal_chondrocyte_physiolo1.91872856
22MP0009384_cardiac_valve_regurgitation1.89135386
23MP0010368_abnormal_lymphatic_system1.84232190
24MP0005171_absent_coat_pigmentation1.82950680
25MP0001879_abnormal_lymphatic_vessel1.80302241
26MP0004885_abnormal_endolymph1.80238471
27* MP0002932_abnormal_joint_morphology1.65834318
28MP0002653_abnormal_ependyma_morphology1.64269665
29MP0009053_abnormal_anal_canal1.63927423
30MP0000751_myopathy1.63235713
31MP0002282_abnormal_trachea_morphology1.62400842
32MP0004145_abnormal_muscle_electrophysio1.59572280
33MP0003942_abnormal_urinary_system1.56241656
34MP0009250_abnormal_appendicular_skeleto1.51314553
35MP0000579_abnormal_nail_morphology1.49189336
36MP0005595_abnormal_vascular_smooth1.47279853
37MP0010030_abnormal_orbit_morphology1.46630054
38MP0006054_spinal_hemorrhage1.45739347
39MP0001542_abnormal_bone_strength1.44308338
40MP0003941_abnormal_skin_development1.42542803
41MP0004134_abnormal_chest_morphology1.42369998
42MP0001348_abnormal_lacrimal_gland1.41467352
43MP0003279_aneurysm1.37606571
44MP0002089_abnormal_postnatal_growth/wei1.35034362
45MP0002249_abnormal_larynx_morphology1.30993424
46MP0000383_abnormal_hair_follicle1.27990452
47MP0002060_abnormal_skin_morphology1.27798125
48MP0000534_abnormal_ureter_morphology1.27771078
49MP0003566_abnormal_cell_adhesion1.27636856
50MP0002938_white_spotting1.27253676
51MP0000767_abnormal_smooth_muscle1.26737444
52MP0010678_abnormal_skin_adnexa1.26388245
53MP0001299_abnormal_eye_distance/1.26372386
54MP0003283_abnormal_digestive_organ1.25986473
55MP0004264_abnormal_extraembryonic_tissu1.25457917
56MP0000733_abnormal_muscle_development1.21714149
57MP0010234_abnormal_vibrissa_follicle1.19284677
58MP0002168_other_aberrant_phenotype1.17463988
59MP0004036_abnormal_muscle_relaxation1.15869509
60MP0000428_abnormal_craniofacial_morphol1.14313084
61MP0002160_abnormal_reproductive_system1.13034179
62MP0003385_abnormal_body_wall1.10684876
63MP0003567_abnormal_fetal_cardiomyocyte1.10473823
64MP0003183_abnormal_peptide_metabolism1.10056862
65MP0003045_fibrosis1.09381613
66MP0003252_abnormal_bile_duct1.07979432
67* MP0000163_abnormal_cartilage_morphology1.07100239
68MP0005023_abnormal_wound_healing1.06582108
69* MP0002115_abnormal_skeleton_extremities1.03320149
70MP0002111_abnormal_tail_morphology1.02212740
71MP0000537_abnormal_urethra_morphology1.02177905
72MP0002295_abnormal_pulmonary_circulatio1.00906911
73MP0002102_abnormal_ear_morphology1.00231515
74* MP0005390_skeleton_phenotype0.95262872
75* MP0000049_abnormal_middle_ear0.95243687
76MP0004858_abnormal_nervous_system0.94849215
77MP0002113_abnormal_skeleton_development0.93211015
78MP0000538_abnormal_urinary_bladder0.92726381
79MP0000762_abnormal_tongue_morphology0.90841968
80MP0002009_preneoplasia0.89784119
81MP0005360_urolithiasis0.88841672
82MP0005197_abnormal_uvea_morphology0.88661931
83MP0002108_abnormal_muscle_morphology0.86777721
84MP0005248_abnormal_Harderian_gland0.83433513
85MP0001175_abnormal_lung_morphology0.82442842
86MP0008770_decreased_survivor_rate0.81097570
87MP0003938_abnormal_ear_development0.79585000
88MP0005620_abnormal_muscle_contractility0.78464110
89MP0008872_abnormal_physiological_respon0.76904531
90MP0000749_muscle_degeneration0.76749760
91MP0001664_abnormal_digestion0.75736278
92MP0002896_abnormal_bone_mineralization0.75335691
93MP0003755_abnormal_palate_morphology0.75005536
94MP0004087_abnormal_muscle_fiber0.74840856
95MP0000427_abnormal_hair_cycle0.73892426
96* MP0002116_abnormal_craniofacial_bone0.72861958
97MP0006138_congestive_heart_failure0.72530205
98MP0002697_abnormal_eye_size0.71394892
99MP0002837_dystrophic_cardiac_calcinosis0.71175060
100MP0008775_abnormal_heart_ventricle0.70682959
101MP0000013_abnormal_adipose_tissue0.70662235
102MP0001849_ear_inflammation0.70531984
103MP0002933_joint_inflammation0.69729688
104MP0000230_abnormal_systemic_arterial0.69712396
105MP0003123_paternal_imprinting0.69456161
106MP0005389_reproductive_system_phenotype0.68092110
107MP0000432_abnormal_head_morphology0.67800006
108MP0002127_abnormal_cardiovascular_syste0.67506343
109MP0004510_myositis0.65192860
110MP0000569_abnormal_digit_pigmentation0.64689477
111MP0005076_abnormal_cell_differentiation0.64561207
112MP0003091_abnormal_cell_migration0.63711328
113* MP0002109_abnormal_limb_morphology0.63527243
114MP0001915_intracranial_hemorrhage0.63413150
115MP0001614_abnormal_blood_vessel0.63356720
116MP0003453_abnormal_keratinocyte_physiol0.63139889
117MP0000462_abnormal_digestive_system0.62924094
118MP0001486_abnormal_startle_reflex0.62769837
119MP0003119_abnormal_digestive_system0.62690572
120MP0003646_muscle_fatigue0.62243723
121MP0003935_abnormal_craniofacial_develop0.60342754
122MP0002114_abnormal_axial_skeleton0.58831408
123MP0004142_abnormal_muscle_tone0.57758530
124MP0005385_cardiovascular_system_phenoty0.57553671
125MP0001544_abnormal_cardiovascular_syste0.57553671
126MP0002233_abnormal_nose_morphology0.57494760
127MP0010630_abnormal_cardiac_muscle0.57486767
128MP0005369_muscle_phenotype0.57463733
129MP0005257_abnormal_intraocular_pressure0.57204524
130MP0002128_abnormal_blood_circulation0.56929972
131MP0010352_gastrointestinal_tract_polyps0.56342295
132MP0001243_abnormal_dermal_layer0.56287211
133MP0002925_abnormal_cardiovascular_devel0.55932945
134MP0003937_abnormal_limbs/digits/tail_de0.55734288
135MP0004197_abnormal_fetal_growth/weight/0.53793840
136MP0005388_respiratory_system_phenotype0.53293057
137MP0002133_abnormal_respiratory_system0.53293057
138MP0000759_abnormal_skeletal_muscle0.53030933
139MP0002234_abnormal_pharynx_morphology0.51544096
140MP0004215_abnormal_myocardial_fiber0.51335276
141MP0005193_abnormal_anterior_eye0.51258754

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the pubic bone (HP:0009104)7.43102691
2Anomalous pulmonary venous return (HP:0010772)7.17221595
3Hypoplastic ischia (HP:0003175)6.75313316
4Epiphyseal dysplasia (HP:0002656)6.74857350
5Abnormality of the pulmonary veins (HP:0011718)6.52884549
6Abnormality of the ischium (HP:0003174)5.91143930
7Bell-shaped thorax (HP:0001591)5.39171996
8Abnormal vertebral ossification (HP:0100569)5.17610678
9Asymmetry of the thorax (HP:0001555)4.70865982
10Premature rupture of membranes (HP:0001788)4.32393602
11* Mixed hearing impairment (HP:0000410)4.31527328
12Abnormality of the pubic bones (HP:0003172)4.30642775
13Enlarged epiphyses (HP:0010580)4.09079978
14Vertebral clefting (HP:0008428)3.88291179
15Fibular hypoplasia (HP:0003038)3.83789510
16Protrusio acetabuli (HP:0003179)3.82365211
17Abnormality of the intervertebral disk (HP:0005108)3.74413059
18Natal tooth (HP:0000695)3.64796647
19Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.62108681
20Absent epiphyses (HP:0010577)3.62108681
21Delayed closure of the anterior fontanelle (HP:0001476)3.59736340
22Peritonitis (HP:0002586)3.55066308
23Aortic regurgitation (HP:0001659)3.52356193
24Genu recurvatum (HP:0002816)3.42942312
25Severe Myopia (HP:0011003)3.42125759
26Alopecia of scalp (HP:0002293)3.35301656
27Exostoses (HP:0100777)3.25989648
28Protuberant abdomen (HP:0001538)3.15539007
29Congenital sensorineural hearing impairment (HP:0008527)3.01892133
30Osteoarthritis (HP:0002758)2.98961846
31Glossoptosis (HP:0000162)2.97579546
32Platyspondyly (HP:0000926)2.94779381
33Flat capital femoral epiphysis (HP:0003370)2.94445515
34Synostosis of carpal bones (HP:0005048)2.94117336
35Mesomelia (HP:0003027)2.93848814
36Vitreoretinal degeneration (HP:0000655)2.91836997
37Partial agenesis of the corpus callosum (HP:0001338)2.90615648
38Joint stiffness (HP:0001387)2.90108271
39Shallow orbits (HP:0000586)2.88553876
40Aortic valve stenosis (HP:0001650)2.84995626
41Bowel diverticulosis (HP:0005222)2.84550925
42Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.79885058
43Recurrent corneal erosions (HP:0000495)2.77740861
44Vascular tortuosity (HP:0004948)2.74468854
45Aplasia/Hypoplasia of the fibula (HP:0006492)2.74367258
46Mild short stature (HP:0003502)2.73117726
47Flared iliac wings (HP:0002869)2.72628337
48Infantile muscular hypotonia (HP:0008947)2.67314879
49Aortic dissection (HP:0002647)2.65535749
50Renal duplication (HP:0000075)2.60078929
51Humeroradial synostosis (HP:0003041)2.59922710
52Synostosis involving the elbow (HP:0003938)2.59922710
53Round ear (HP:0100830)2.54906828
54Flat cornea (HP:0007720)2.53975388
55Bladder diverticulum (HP:0000015)2.53050264
56Abnormality of midbrain morphology (HP:0002418)2.52727468
57Molar tooth sign on MRI (HP:0002419)2.52727468
58Rhizomelia (HP:0008905)2.49179336
59Ovoid vertebral bodies (HP:0003300)2.48369328
60Knee flexion contracture (HP:0006380)2.46364601
61Wide anterior fontanel (HP:0000260)2.43229744
62Joint contractures involving the joints of the feet (HP:0100492)2.42153829
63Flexion contracture of toe (HP:0005830)2.42153829
64Abnormality of the lumbar spine (HP:0100712)2.39787278
65Follicular hyperkeratosis (HP:0007502)2.37943550
66Broad metatarsal (HP:0001783)2.36990459
67Abnormality of the right ventricle (HP:0001707)2.36345217
68Wrist flexion contracture (HP:0001239)2.35772921
69Flared metaphyses (HP:0003015)2.33935510
70Increased corneal curvature (HP:0100692)2.32185420
71Keratoconus (HP:0000563)2.32185420
72Meningocele (HP:0002435)2.30680201
73Elbow flexion contracture (HP:0002987)2.30556420
74Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.27159954
75Carpal synostosis (HP:0009702)2.26904521
76Absent eyelashes (HP:0000561)2.26741277
77Arterial tortuosity (HP:0005116)2.23145042
78Neonatal short-limb short stature (HP:0008921)2.20680507
79Abnormality of the acetabulum (HP:0003170)2.16137992
80Muscle fiber splitting (HP:0003555)2.15880251
81Mitral stenosis (HP:0001718)2.15113850
82Partial duplication of the phalanx of hand (HP:0009999)2.14620770
83Aplasia involving bones of the upper limbs (HP:0009823)2.13667463
84Aplasia of the phalanges of the hand (HP:0009802)2.13667463
85Aplasia involving bones of the extremities (HP:0009825)2.13667463
86Coronal craniosynostosis (HP:0004440)2.13404568
87Camptodactyly of toe (HP:0001836)2.10546272
88Aneurysm (HP:0002617)2.10330057
89Joint laxity (HP:0001388)2.09356618
90Ankle contracture (HP:0006466)2.06776902
91Ectopia lentis (HP:0001083)2.06646264
92Soft skin (HP:0000977)2.06622274
93Aortic aneurysm (HP:0004942)2.04708275
94Abnormal delivery (HP:0001787)2.04281015
95Broad ribs (HP:0000885)2.02673024
96Tarsal synostosis (HP:0008368)2.01366124
97Cerebral aneurysm (HP:0004944)2.00772853
98Abnormality of the parietal bone (HP:0002696)2.00079691
99Cardiovascular calcification (HP:0011915)1.98101133
100Ulnar deviation of the wrist (HP:0003049)1.95503324
101Irregular epiphyses (HP:0010582)1.95500959
102Synostosis involving bones of the lower limbs (HP:0009138)1.94876489
103Synostosis involving bones of the feet (HP:0009140)1.94876489
104Cervical subluxation (HP:0003308)1.94064349
105Partial duplication of thumb phalanx (HP:0009944)1.92441053
106Patent foramen ovale (HP:0001655)1.91215887
107Delayed cranial suture closure (HP:0000270)1.90330479
108Thin bony cortex (HP:0002753)1.90185253
109Aplasia cutis congenita (HP:0001057)1.88432692
110Mitral valve prolapse (HP:0001634)1.87345344
111Hypoplasia of the odontoid process (HP:0003311)1.87244527
112Vertebral arch anomaly (HP:0008438)1.87067328
113Abnormality of the middle phalanges of the toes (HP:0010183)1.86211192
114Hypoplasia of the iris (HP:0007676)1.85297484
115Arachnodactyly (HP:0001166)1.84888832
116Fibular aplasia (HP:0002990)1.84790763
117Craniofacial hyperostosis (HP:0004493)1.84789751
118Conjugated hyperbilirubinemia (HP:0002908)1.84592818
119Hip contracture (HP:0003273)1.84284718
120Overgrowth (HP:0001548)1.83069102
121Synostosis involving bones of the hand (HP:0004278)1.82662428
122Abnormality of the odontoid process (HP:0003310)1.82520923
123Limited hip movement (HP:0008800)1.81954720
124Lumbar hyperlordosis (HP:0002938)1.81532152
125Dilatation of the ascending aorta (HP:0005111)1.79846605
126Tracheomalacia (HP:0002779)1.79387267
127Morphological abnormality of the middle ear (HP:0008609)1.79310182
128Mildly elevated creatine phosphokinase (HP:0008180)1.77110686
129Biconcave vertebral bodies (HP:0004586)1.77087787
130Disproportionate tall stature (HP:0001519)1.76213612
131Abnormality of the anterior chamber (HP:0000593)1.76120483
132Advanced eruption of teeth (HP:0006288)1.75892746
133Hypoplastic ilia (HP:0000946)1.75590435
134Amniotic constriction ring (HP:0009775)1.75343345
135Abnormality of placental membranes (HP:0011409)1.75343345
136* Sprengel anomaly (HP:0000912)1.74877198
137Fragile skin (HP:0001030)1.74382111
138Atrophic scars (HP:0001075)1.73300482
139Blue sclerae (HP:0000592)1.73059659
140Abnormality of the wing of the ilium (HP:0011867)1.72469061
141Hypoventilation (HP:0002791)1.72320270
142Short thorax (HP:0010306)1.72265464
143Mitral regurgitation (HP:0001653)1.72159180
144Radial bowing (HP:0002986)1.71848441
145Abnormality of nail color (HP:0100643)1.71571992
146Broad long bones (HP:0005622)1.71536031
147Hallux valgus (HP:0001822)1.69701616
148Chorioretinal atrophy (HP:0000533)1.69318737
149Long toe (HP:0010511)1.68852544
150Decreased skull ossification (HP:0004331)1.68121076
151Abnormality of dentin (HP:0010299)1.67536955
152Hyperextensible skin (HP:0000974)1.67144266
153Wormian bones (HP:0002645)1.66993149
154Congenital stationary night blindness (HP:0007642)1.66886680
155Spinal rigidity (HP:0003306)1.66850448
156Spina bifida occulta (HP:0003298)1.66773895
157Thickened calvaria (HP:0002684)1.66182317
158Bradycardia (HP:0001662)1.66029797
159Nephronophthisis (HP:0000090)1.65687753
160Pulmonary artery stenosis (HP:0004415)1.65417672
161Alacrima (HP:0000522)1.64512548
162Femoral bowing (HP:0002980)1.63970823
163Spondylolisthesis (HP:0003302)1.63404514
164Type 1 muscle fiber predominance (HP:0003803)1.63205168
165Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.62896300
166Bulbous nose (HP:0000414)1.62812922
167Micromelia (HP:0002983)1.62614370
168Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60377028

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.66971386
2PRKG23.03157023
3STK38L2.82959282
4LATS12.64756087
5TRIB32.60933218
6TAF12.60421397
7TIE12.40389919
8MELK2.29526027
9TRPM72.24814384
10VRK22.22813687
11MUSK2.10021840
12DDR213.6017747
13BMPR21.92686626
14SMG11.84328091
15SIK11.82909283
16RIPK11.80108933
17PDGFRA1.79229388
18NEK21.77613413
19FLT31.73784294
20PKN21.73286693
21PIK3CG1.73140036
22NEK91.72110815
23DYRK1B1.65690277
24TESK21.60954166
25PINK11.58105909
26MAPKAPK51.52984220
27TTN1.51502833
28TLK11.46692995
29ADRBK21.44155444
30LATS21.39491681
31STK381.38672866
32CDK61.33957982
33PTK61.30892272
34EPHB21.22511443
35EPHB11.21995764
36FRK1.21003525
37ERBB31.20329199
38STK111.17904238
39PAK41.16895479
40RIPK41.11422405
41PAK31.09032093
42MAP3K101.05233418
43MAPK71.01888740
44ADRBK11.01231674
45UHMK10.99699647
46ZAK0.99374666
47PAK20.99107789
48GRK10.96695370
49FER0.94537912
50FGFR10.94369040
51MARK30.91467992
52PTK20.88590326
53MAPKAPK30.87858386
54PRKD30.80935537
55PRKCG0.80011334
56ERBB20.78296050
57FGFR30.78058979
58LRRK20.78056190
59PRKCE0.77740068
60ERN10.74150806
61BMX0.69823160
62KIT0.69234689
63CHEK20.68369100
64BMPR1B0.68222503
65YES10.65275102
66NTRK10.64626130
67PTK2B0.63914410
68STK30.63883704
69DAPK10.62974184
70PIM20.59369883
71WNK40.59247158
72TESK10.59036189
73DAPK20.58527730
74ILK0.58313167
75ROCK20.58071118
76WNK10.57757149
77DMPK0.57124630
78JAK30.56453644
79PHKG20.56229524
80PHKG10.56229524
81INSRR0.56217577
82PRKAA10.55911290
83PDGFRB0.55602980
84PRKAA20.55391005
85GRK50.55307589
86MAP3K20.54790159
87PAK60.52795665
88MET0.51859924
89MAPK150.48516517
90DAPK30.48235905
91PRKCH0.46189762
92ROCK10.46072171
93CAMK1G0.46001621
94TGFBR10.44474691
95MAP3K90.42979863
96LIMK10.42786154
97ERBB40.40826513
98CAMK2D0.40130742
99RET0.40065877
100SIK20.39116394
101MAP2K10.39103599
102KSR20.39002095
103KSR10.38576661
104CSNK1G10.38539912
105FGFR20.38159688
106MTOR0.38005924
107ICK0.37974017
108EEF2K0.37953352
109TGFBR20.37888546
110HIPK20.37559212
111RPS6KL10.36928128
112RPS6KC10.36928128
113CDC42BPA0.36121200
114CAMK2B0.35731169
115PLK20.34708207
116LMTK20.33475027
117CAMK2A0.32778247
118CSNK1A1L0.32288659
119PAK10.32160381
120PRKD20.32074006
121MAP3K70.32001869
122MAP3K40.31935934
123STK240.31714564
124SCYL20.31240605
125STK390.31182080
126PRKD10.28815659
127PRKCA0.28602988
128EPHA30.28460783
129NUAK10.28080160
130MAP3K120.27638330
131CDK140.27357405
132CAMK10.27296344
133PLK30.26738846
134RPS6KA60.26574767
135SRC0.26428040
136PRKCI0.26287583
137ZAP700.25887057
138GSK3A0.24419321
139TYRO30.24278327
140PIK3CA0.24247385
141GRK70.22297708
142MOS0.21691590
143ABL10.20407702
144MAP2K20.19993996
145CSNK1E0.19934305
146ALK0.19576223
147INSR0.18893466
148EGFR0.18514297
149NTRK30.18378423
150BCR0.17734792
151MKNK10.17216430
152CDK50.16656487
153RPS6KA20.16343221
154FGFR40.15080057

Predicted pathways (KEGG)

RankGene SetZ-score
1Other types of O-glycan biosynthesis_Homo sapiens_hsa005144.71279805
2Notch signaling pathway_Homo sapiens_hsa043303.00264884
3ECM-receptor interaction_Homo sapiens_hsa045122.95531534
4Basal cell carcinoma_Homo sapiens_hsa052172.86694165
5Protein digestion and absorption_Homo sapiens_hsa049742.79403382
6* Hippo signaling pathway_Homo sapiens_hsa043902.63008572
7Dorso-ventral axis formation_Homo sapiens_hsa043202.22913605
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.16325091
9Focal adhesion_Homo sapiens_hsa045102.12032679
10Proteoglycans in cancer_Homo sapiens_hsa052051.96237984
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90968266
12* TGF-beta signaling pathway_Homo sapiens_hsa043501.89632312
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.82098923
14Olfactory transduction_Homo sapiens_hsa047401.74954553
15Bladder cancer_Homo sapiens_hsa052191.68525450
16Salivary secretion_Homo sapiens_hsa049701.68497189
17Melanogenesis_Homo sapiens_hsa049161.67402354
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.64147831
19Tight junction_Homo sapiens_hsa045301.59859274
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.55800674
21Dilated cardiomyopathy_Homo sapiens_hsa054141.49900095
22Morphine addiction_Homo sapiens_hsa050321.46635753
23Fatty acid biosynthesis_Homo sapiens_hsa000611.45021464
24Lysine degradation_Homo sapiens_hsa003101.44968067
25Circadian entrainment_Homo sapiens_hsa047131.44804350
26Axon guidance_Homo sapiens_hsa043601.44639363
27Adherens junction_Homo sapiens_hsa045201.44361321
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.42644051
29Amoebiasis_Homo sapiens_hsa051461.40123613
30Hedgehog signaling pathway_Homo sapiens_hsa043401.38221732
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35907359
32Wnt signaling pathway_Homo sapiens_hsa043101.34461223
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31579694
34Insulin secretion_Homo sapiens_hsa049111.29037695
35Chronic myeloid leukemia_Homo sapiens_hsa052201.28300255
36Selenocompound metabolism_Homo sapiens_hsa004501.26346559
37Glutamatergic synapse_Homo sapiens_hsa047241.24351888
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20843003
39GABAergic synapse_Homo sapiens_hsa047271.18809754
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17362471
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16488673
42Calcium signaling pathway_Homo sapiens_hsa040201.15269987
43Long-term depression_Homo sapiens_hsa047301.14807039
44Cholinergic synapse_Homo sapiens_hsa047251.12692324
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.12439519
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09056410
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08562017
48Renin secretion_Homo sapiens_hsa049241.07967964
49p53 signaling pathway_Homo sapiens_hsa041151.07600782
50MicroRNAs in cancer_Homo sapiens_hsa052061.06757173
51Small cell lung cancer_Homo sapiens_hsa052221.06219308
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05003579
53Estrogen signaling pathway_Homo sapiens_hsa049151.04922957
54Oxytocin signaling pathway_Homo sapiens_hsa049211.00977406
55PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00918065
56Melanoma_Homo sapiens_hsa052180.94211690
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93911728
58Nitrogen metabolism_Homo sapiens_hsa009100.93773189
59Pathways in cancer_Homo sapiens_hsa052000.93716578
60ErbB signaling pathway_Homo sapiens_hsa040120.93632857
61Glioma_Homo sapiens_hsa052140.92601157
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.91439137
63Viral myocarditis_Homo sapiens_hsa054160.91138997
64Fatty acid degradation_Homo sapiens_hsa000710.90087345
65Prostate cancer_Homo sapiens_hsa052150.88339492
66N-Glycan biosynthesis_Homo sapiens_hsa005100.88311874
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87925947
68Complement and coagulation cascades_Homo sapiens_hsa046100.86872142
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86483459
70Phototransduction_Homo sapiens_hsa047440.84128388
71Serotonergic synapse_Homo sapiens_hsa047260.82567137
72Sphingolipid metabolism_Homo sapiens_hsa006000.75606511
73Inositol phosphate metabolism_Homo sapiens_hsa005620.75283896
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74902307
75Insulin resistance_Homo sapiens_hsa049310.74854390
76Fatty acid metabolism_Homo sapiens_hsa012120.74485965
77Colorectal cancer_Homo sapiens_hsa052100.72958155
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72740264
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71992788
80cAMP signaling pathway_Homo sapiens_hsa040240.71943404
81Rap1 signaling pathway_Homo sapiens_hsa040150.71575983
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.70550082
83PPAR signaling pathway_Homo sapiens_hsa033200.70383507
84Renal cell carcinoma_Homo sapiens_hsa052110.69170450
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68626137
86Ovarian steroidogenesis_Homo sapiens_hsa049130.66373519
87African trypanosomiasis_Homo sapiens_hsa051430.66129006
88Cocaine addiction_Homo sapiens_hsa050300.65536257
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.64383173
90Gap junction_Homo sapiens_hsa045400.63410519
91Thyroid hormone synthesis_Homo sapiens_hsa049180.62812637
92Sulfur metabolism_Homo sapiens_hsa009200.61893771
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60448372
94Basal transcription factors_Homo sapiens_hsa030220.58967252
95GnRH signaling pathway_Homo sapiens_hsa049120.55565336
96Prion diseases_Homo sapiens_hsa050200.54635982
97Pancreatic cancer_Homo sapiens_hsa052120.53076954
98Choline metabolism in cancer_Homo sapiens_hsa052310.53050631
99Malaria_Homo sapiens_hsa051440.51185172
100Amphetamine addiction_Homo sapiens_hsa050310.51092497
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.50233683
102HTLV-I infection_Homo sapiens_hsa051660.50053012
103Endometrial cancer_Homo sapiens_hsa052130.49069888
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48712134
105Cardiac muscle contraction_Homo sapiens_hsa042600.48297690
106Taste transduction_Homo sapiens_hsa047420.47941617
107Platelet activation_Homo sapiens_hsa046110.47744296
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47494701
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47378374
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47311708
111TNF signaling pathway_Homo sapiens_hsa046680.46335745
112Nicotine addiction_Homo sapiens_hsa050330.44513721
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44417437
114Gastric acid secretion_Homo sapiens_hsa049710.44367905
115Insulin signaling pathway_Homo sapiens_hsa049100.44252556
116Butanoate metabolism_Homo sapiens_hsa006500.43720684
117VEGF signaling pathway_Homo sapiens_hsa043700.42714194
118Arginine biosynthesis_Homo sapiens_hsa002200.40824517
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40175527
120Glucagon signaling pathway_Homo sapiens_hsa049220.39981377
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39834663
122Ras signaling pathway_Homo sapiens_hsa040140.39021540
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.38576094
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.37001491
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36345740
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.35951695
127Dopaminergic synapse_Homo sapiens_hsa047280.35581029
128Circadian rhythm_Homo sapiens_hsa047100.35232810
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.35097019
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34756813
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34407456
132Linoleic acid metabolism_Homo sapiens_hsa005910.33828243
133Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33513295
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33462959
135Hepatitis B_Homo sapiens_hsa051610.32336534
136Bile secretion_Homo sapiens_hsa049760.31006534
137Toxoplasmosis_Homo sapiens_hsa051450.30806380
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30414232
139MAPK signaling pathway_Homo sapiens_hsa040100.29104000
140FoxO signaling pathway_Homo sapiens_hsa040680.29046119
141Starch and sucrose metabolism_Homo sapiens_hsa005000.28669349

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