GDF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.99635184
2neuron cell-cell adhesion (GO:0007158)5.71411219
3cellular potassium ion homeostasis (GO:0030007)5.56417362
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.54548391
5sodium ion export (GO:0071436)4.96220580
6membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.82876077
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.79239129
8neuron recognition (GO:0008038)4.64729448
9neuronal action potential propagation (GO:0019227)4.62980729
10L-amino acid import (GO:0043092)4.60998047
11glutamate receptor signaling pathway (GO:0007215)4.44231245
12protein localization to synapse (GO:0035418)4.43948702
13regulation of glutamate secretion (GO:0014048)4.39810610
14vocalization behavior (GO:0071625)4.36624249
15potassium ion import (GO:0010107)4.32547797
16axonal fasciculation (GO:0007413)4.31030000
17regulation of synaptic vesicle transport (GO:1902803)4.29969900
18potassium ion homeostasis (GO:0055075)4.29803103
19gamma-aminobutyric acid signaling pathway (GO:0007214)4.28077828
20transmission of nerve impulse (GO:0019226)4.27388034
21cerebellar granule cell differentiation (GO:0021707)4.25201858
22regulation of synapse structural plasticity (GO:0051823)4.22136159
23amino acid import (GO:0043090)4.20603664
24establishment of mitochondrion localization (GO:0051654)4.12659004
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.04578295
26presynaptic membrane assembly (GO:0097105)4.03529934
27synaptic transmission, glutamatergic (GO:0035249)4.02890465
28neurotransmitter-gated ion channel clustering (GO:0072578)3.97442561
29synaptic vesicle exocytosis (GO:0016079)3.93763039
30positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.92622608
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.92372202
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.87165540
33positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.85859049
34cell migration in hindbrain (GO:0021535)3.83227029
35neuron-neuron synaptic transmission (GO:0007270)3.82816989
36presynaptic membrane organization (GO:0097090)3.76627356
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.72831864
38cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71714549
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.68064563
40ATP synthesis coupled proton transport (GO:0015986)3.68064563
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67497475
42regulation of synapse maturation (GO:0090128)3.63476181
43auditory behavior (GO:0031223)3.62661541
44negative regulation of amino acid transport (GO:0051956)3.61609060
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.57383963
46positive regulation of synapse assembly (GO:0051965)3.54763389
47startle response (GO:0001964)3.53337076
48locomotory exploration behavior (GO:0035641)3.50670885
49cerebellar Purkinje cell differentiation (GO:0021702)3.50290884
50postsynaptic membrane organization (GO:0001941)3.49611983
51neuromuscular process controlling balance (GO:0050885)3.44374551
52cellular sodium ion homeostasis (GO:0006883)3.44156967
53layer formation in cerebral cortex (GO:0021819)3.43391873
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42816375
55regulation of glutamate receptor signaling pathway (GO:1900449)3.41979500
56cerebral cortex radially oriented cell migration (GO:0021799)3.40740058
57astrocyte differentiation (GO:0048708)3.40191555
58cell communication by electrical coupling (GO:0010644)3.39134134
59acidic amino acid transport (GO:0015800)3.38590117
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.36970926
61regulation of neurotransmitter levels (GO:0001505)3.36056160
62regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.33361356
63exploration behavior (GO:0035640)3.31950440
64establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31668754
65mitochondrion transport along microtubule (GO:0047497)3.31668754
66glycerophospholipid catabolic process (GO:0046475)3.29211217
67positive regulation of synapse maturation (GO:0090129)3.22388706
68long-term synaptic potentiation (GO:0060291)3.20518129
69regulation of feeding behavior (GO:0060259)3.18959457
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.17422435
71cerebellar Purkinje cell layer development (GO:0021680)3.17123465
72neurotransmitter uptake (GO:0001504)3.16625221
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15996438
74regulation of neurotransmitter secretion (GO:0046928)3.15975995
75regulation of inositol phosphate biosynthetic process (GO:0010919)3.14261965
76dendritic spine organization (GO:0097061)3.12156386
77regulation of neurotransmitter transport (GO:0051588)3.12111036
78behavioral fear response (GO:0001662)3.10027719
79behavioral defense response (GO:0002209)3.10027719
80response to auditory stimulus (GO:0010996)3.09825524
81regulation of vesicle fusion (GO:0031338)3.09732389
82chaperone-mediated protein transport (GO:0072321)3.09284427
83dendrite development (GO:0016358)3.07265822
84regulation of excitatory postsynaptic membrane potential (GO:0060079)3.07103409
85negative regulation of axon extension (GO:0030517)3.05847754
86axon ensheathment in central nervous system (GO:0032291)3.05289520
87central nervous system myelination (GO:0022010)3.05289520
88L-glutamate transport (GO:0015813)3.05253566
89neuromuscular synaptic transmission (GO:0007274)3.04461711
90negative regulation of neurotransmitter transport (GO:0051589)3.03939903
91regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03930046
92mechanosensory behavior (GO:0007638)3.03513001
93pyrimidine nucleobase catabolic process (GO:0006208)3.02682187
94fear response (GO:0042596)3.02650673
95response to histamine (GO:0034776)3.01926073
96retinal ganglion cell axon guidance (GO:0031290)3.00903351
97synapse assembly (GO:0007416)2.98205592
98regulation of neuronal synaptic plasticity (GO:0048168)2.97826600
99cell differentiation in hindbrain (GO:0021533)2.97671350
100positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97436182
101regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.96262470
102long-term memory (GO:0007616)2.95901474
103glutamate secretion (GO:0014047)2.94838750
104respiratory electron transport chain (GO:0022904)2.94732383
105neuronal ion channel clustering (GO:0045161)2.94561484
106adult walking behavior (GO:0007628)2.94505664
107regulation of dendritic spine development (GO:0060998)2.93987474
108positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93833722
109opioid receptor signaling pathway (GO:0038003)2.93371084
110regulation of postsynaptic membrane potential (GO:0060078)2.92681072
111regulation of voltage-gated calcium channel activity (GO:1901385)2.92266672
112astrocyte development (GO:0014002)2.92158832
113regulation of synaptic plasticity (GO:0048167)2.91775671
114electron transport chain (GO:0022900)2.90755354
115gamma-aminobutyric acid transport (GO:0015812)2.89596976
116learning (GO:0007612)2.89224837
117regulation of neurotransmitter uptake (GO:0051580)2.88919635
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.87283182
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86837330
120synaptic transmission, dopaminergic (GO:0001963)2.86702373
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.86361455
122regulation of respiratory system process (GO:0044065)2.86333370
123dendritic spine morphogenesis (GO:0060997)2.85999886
124female mating behavior (GO:0060180)2.85614933
125negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83929129
126long-chain fatty acid biosynthetic process (GO:0042759)2.83344136
127positive regulation of dendrite development (GO:1900006)2.82133586
128neuromuscular process controlling posture (GO:0050884)2.82129147
129dendrite morphogenesis (GO:0048813)2.80349535
130positive regulation of dendritic spine development (GO:0060999)2.79544104
131neurotransmitter secretion (GO:0007269)2.79536298
132membrane hyperpolarization (GO:0060081)2.79489101
133regulation of amino acid transport (GO:0051955)2.79364149
134positive regulation of cellular response to oxidative stress (GO:1900409)2.78894959
135positive regulation of response to oxidative stress (GO:1902884)2.78894959
136calcium-mediated signaling using intracellular calcium source (GO:0035584)2.78702075
137short-term memory (GO:0007614)2.73723748
138positive regulation of dendritic spine morphogenesis (GO:0061003)2.72083301
139negative regulation of amine transport (GO:0051953)2.71556116
140central nervous system projection neuron axonogenesis (GO:0021952)2.70160843
141righting reflex (GO:0060013)2.69312111
142positive regulation of membrane potential (GO:0045838)2.69230655
143regulation of synaptic vesicle exocytosis (GO:2000300)2.68362939
144synaptic vesicle endocytosis (GO:0048488)2.67426152
145regulation of synapse assembly (GO:0051963)2.65949341
146regulation of dendritic spine morphogenesis (GO:0061001)2.64750986
147negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.64379442
148ephrin receptor signaling pathway (GO:0048013)2.63954447
149neurotransmitter transport (GO:0006836)2.62588549
150GTP biosynthetic process (GO:0006183)2.62546787

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.02744126
2GBX2_23144817_ChIP-Seq_PC3_Human3.89224465
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20813263
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09940213
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08134440
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.81308926
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68670461
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62828095
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.61799298
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61525998
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58643917
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58643917
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50167900
14REST_21632747_ChIP-Seq_MESCs_Mouse2.44637109
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.44457278
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.40241866
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29908987
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26477644
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24002511
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.20853539
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18740695
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.18555760
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17267787
24TAF15_26573619_Chip-Seq_HEK293_Human2.14759973
25CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09931829
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.09371143
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09246329
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07073413
29VDR_22108803_ChIP-Seq_LS180_Human2.06612835
30ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02138227
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96709414
32KDM2B_26808549_Chip-Seq_K562_Human1.95088790
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.94604075
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93417513
35AR_21572438_ChIP-Seq_LNCaP_Human1.89837921
36* RARB_27405468_Chip-Seq_BRAIN_Mouse1.88297029
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86771424
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.85298266
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.85012582
40FUS_26573619_Chip-Seq_HEK293_Human1.84247104
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82359320
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74764708
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73753303
44ZNF274_21170338_ChIP-Seq_K562_Hela1.72774574
45CTCF_27219007_Chip-Seq_Bcells_Human1.70170276
46P300_19829295_ChIP-Seq_ESCs_Human1.67110446
47* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65632722
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.65486769
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61827703
50LXR_22292898_ChIP-Seq_THP-1_Human1.60529453
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55625713
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53183178
53IGF1R_20145208_ChIP-Seq_DFB_Human1.51491443
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.51164871
55RNF2_27304074_Chip-Seq_NSC_Mouse1.50140378
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44900682
57GATA1_26923725_Chip-Seq_HPCs_Mouse1.42173361
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35906939
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.34891068
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.34590551
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34556522
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34466947
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33615660
64SMAD4_21799915_ChIP-Seq_A2780_Human1.32576013
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31635379
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29081488
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27637708
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27637708
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24509946
70DROSHA_22980978_ChIP-Seq_HELA_Human1.24005838
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.23374469
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20505756
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20012908
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.19732551
75EWS_26573619_Chip-Seq_HEK293_Human1.18700004
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18003878
77SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17113603
78* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15781992
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15765149
80* JUN_21703547_ChIP-Seq_K562_Human1.15331950
81SMC4_20622854_ChIP-Seq_HELA_Human1.14578797
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13896636
83P68_20966046_ChIP-Seq_HELA_Human1.13398071
84OCT4_19829295_ChIP-Seq_ESCs_Human1.12494053
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.12353820
86WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11629276
87AR_25329375_ChIP-Seq_VCAP_Human1.11060096
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10482630
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.08941433
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.07362011
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07191712
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06384704
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02533459
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02023264
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.00928884
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00635575
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00129647
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.99910281
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99888880
100ESR2_21235772_ChIP-Seq_MCF-7_Human0.99065334
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99005853
102SOX9_26525672_Chip-Seq_HEART_Mouse0.97438368
103MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.96310650
104KDM2B_26808549_Chip-Seq_DND41_Human0.95261935
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94070847
106* RUNX2_22187159_ChIP-Seq_PCA_Human0.93730086
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.93647065
108ER_23166858_ChIP-Seq_MCF-7_Human0.93535215
109NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93503157
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.93006184
111CREB1_26743006_Chip-Seq_LNCaP_Human0.92350868
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92062034
113PRDM14_20953172_ChIP-Seq_ESCs_Human0.92052867
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91261384
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90924731
116NANOG_18555785_Chip-Seq_ESCs_Mouse0.90415621
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89336672
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.88832479
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87642043
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87510446
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.87484023
122POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86627191
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86430712
124STAT3_23295773_ChIP-Seq_U87_Human0.86155862
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.86145646
126KLF4_19829295_ChIP-Seq_ESCs_Human0.85905059
127TCF4_23295773_ChIP-Seq_U87_Human0.85890303
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85678567
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.85553468
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.85344408
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85288874
132SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85119252
133DPY_21335234_ChIP-Seq_ESCs_Mouse0.84716252
134AR_19668381_ChIP-Seq_PC3_Human0.82367494
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.81833533
136GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81420161
137SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80911385
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.80028198
139TP53_18474530_ChIP-ChIP_U2OS_Human0.80010152
140SMAD4_21741376_ChIP-Seq_ESCs_Human0.79733028
141GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79628928
142E2F1_18555785_Chip-Seq_ESCs_Mouse0.79446945
143ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78914186
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78736192
145SA1_27219007_Chip-Seq_ERYTHROID_Human0.78473759
146CMYC_18555785_Chip-Seq_ESCs_Mouse0.78258439
147POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.78115697
148NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77566804
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77287520
150SA1_27219007_Chip-Seq_Bcells_Human0.74894670
151DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.72811047
152MYC_27129775_Chip-Seq_CORNEA_Mouse0.72619031
153MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.71079230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.07888963
2MP0004859_abnormal_synaptic_plasticity4.09148300
3MP0003635_abnormal_synaptic_transmissio3.24611949
4MP0005423_abnormal_somatic_nervous3.10811504
5MP0001968_abnormal_touch/_nociception3.05792347
6MP0009745_abnormal_behavioral_response3.03371441
7MP0001440_abnormal_grooming_behavior2.80385620
8MP0002063_abnormal_learning/memory/cond2.78516621
9MP0002064_seizures2.74299096
10MP0002736_abnormal_nociception_after2.70633107
11MP0006276_abnormal_autonomic_nervous2.61729801
12MP0004270_analgesia2.60084144
13MP0002735_abnormal_chemical_nociception2.58177901
14MP0001529_abnormal_vocalization2.57750518
15MP0002572_abnormal_emotion/affect_behav2.57385172
16MP0002272_abnormal_nervous_system2.50761104
17MP0001486_abnormal_startle_reflex2.34067017
18MP0004142_abnormal_muscle_tone2.21961523
19MP0001501_abnormal_sleep_pattern2.17111174
20MP0000778_abnormal_nervous_system2.11974718
21MP0009046_muscle_twitch2.08922777
22MP0001188_hyperpigmentation2.03482584
23MP0001905_abnormal_dopamine_level2.03207967
24MP0002733_abnormal_thermal_nociception1.99534021
25MP0002822_catalepsy1.99372940
26MP0003122_maternal_imprinting1.96642262
27MP0002067_abnormal_sensory_capabilities1.93186039
28MP0002734_abnormal_mechanical_nocicepti1.91777156
29MP0006292_abnormal_olfactory_placode1.86492620
30MP0001970_abnormal_pain_threshold1.81534469
31MP0002184_abnormal_innervation1.73907643
32MP0005645_abnormal_hypothalamus_physiol1.71536124
33MP0003123_paternal_imprinting1.70986983
34MP0009379_abnormal_foot_pigmentation1.68803320
35MP0005167_abnormal_blood-brain_barrier1.68524573
36MP0009780_abnormal_chondrocyte_physiolo1.65877454
37MP0001984_abnormal_olfaction1.65144276
38MP0003633_abnormal_nervous_system1.63420284
39MP0002557_abnormal_social/conspecific_i1.62824548
40MP0004885_abnormal_endolymph1.55385355
41MP0004924_abnormal_behavior1.54437267
42MP0005386_behavior/neurological_phenoty1.54437267
43MP0008877_abnormal_DNA_methylation1.54121158
44MP0003121_genomic_imprinting1.49592825
45MP0002653_abnormal_ependyma_morphology1.48304345
46MP0000955_abnormal_spinal_cord1.46787174
47MP0003787_abnormal_imprinting1.45054349
48MP0002882_abnormal_neuron_morphology1.44073449
49MP0004742_abnormal_vestibular_system1.43811605
50MP0001485_abnormal_pinna_reflex1.42308750
51MP0003136_yellow_coat_color1.41570453
52MP0001502_abnormal_circadian_rhythm1.33166002
53MP0005409_darkened_coat_color1.31905209
54MP0002066_abnormal_motor_capabilities/c1.28999156
55MP0004858_abnormal_nervous_system1.27463339
56MP0002751_abnormal_autonomic_nervous1.23733700
57MP0003329_amyloid_beta_deposits1.23459564
58MP0005551_abnormal_eye_electrophysiolog1.21544294
59MP0002752_abnormal_somatic_nervous1.21467212
60MP0004145_abnormal_muscle_electrophysio1.19875772
61MP0001963_abnormal_hearing_physiology1.18705275
62MP0002102_abnormal_ear_morphology1.18115592
63MP0001348_abnormal_lacrimal_gland1.17931569
64MP0005171_absent_coat_pigmentation1.16680421
65MP0000631_abnormal_neuroendocrine_gland1.15388516
66MP0003938_abnormal_ear_development1.14621314
67MP0006072_abnormal_retinal_apoptosis1.12415725
68* MP0002152_abnormal_brain_morphology1.12322471
69MP0000026_abnormal_inner_ear1.12012558
70MP0001986_abnormal_taste_sensitivity1.10489769
71MP0004811_abnormal_neuron_physiology1.10372323
72MP0000751_myopathy1.09486499
73MP0005646_abnormal_pituitary_gland1.05202588
74MP0002909_abnormal_adrenal_gland1.01792547
75MP0002229_neurodegeneration1.00391203
76MP0002249_abnormal_larynx_morphology0.99083479
77MP0004130_abnormal_muscle_cell0.98514175
78MP0008569_lethality_at_weaning0.98021998
79MP0003137_abnormal_impulse_conducting0.95703620
80MP0003690_abnormal_glial_cell0.92779947
81MP0000604_amyloidosis0.92351426
82MP0003075_altered_response_to0.90036360
83MP0003634_abnormal_glial_cell0.86737764
84* MP0003861_abnormal_nervous_system0.85764177
85MP0000920_abnormal_myelination0.85522947
86MP0005379_endocrine/exocrine_gland_phen0.83635271
87MP0002638_abnormal_pupillary_reflex0.81154254
88MP0002876_abnormal_thyroid_physiology0.80846744
89MP0002069_abnormal_eating/drinking_beha0.80731014
90* MP0004133_heterotaxia0.80526773
91MP0001299_abnormal_eye_distance/0.79766862
92MP0001177_atelectasis0.78664975
93MP0003283_abnormal_digestive_organ0.75901274
94MP0005394_taste/olfaction_phenotype0.74458222
95MP0005499_abnormal_olfactory_system0.74458222
96MP0003890_abnormal_embryonic-extraembry0.72768090
97MP0003879_abnormal_hair_cell0.71620867
98MP0000579_abnormal_nail_morphology0.70571532
99MP0000049_abnormal_middle_ear0.68719855
100MP0002332_abnormal_exercise_endurance0.68562427
101MP0003632_abnormal_nervous_system0.68255882
102MP0001346_abnormal_lacrimal_gland0.67130998
103MP0003631_nervous_system_phenotype0.66710598
104MP0000566_synostosis0.66105375
105MP0005195_abnormal_posterior_eye0.65554254
106MP0008872_abnormal_physiological_respon0.65523598
107MP0010386_abnormal_urinary_bladder0.61447536
108MP0002837_dystrophic_cardiac_calcinosis0.59597729
109MP0005410_abnormal_fertilization0.58863671
110MP0002163_abnormal_gland_morphology0.57807551
111MP0005623_abnormal_meninges_morphology0.57516351
112MP0001943_abnormal_respiration0.57156780
113MP0000747_muscle_weakness0.56900847
114MP0005253_abnormal_eye_physiology0.56821518
115MP0008874_decreased_physiological_sensi0.56722596
116MP0001664_abnormal_digestion0.56318743
117MP0008789_abnormal_olfactory_epithelium0.56090538
118MP0005535_abnormal_body_temperature0.55889314
119MP0000534_abnormal_ureter_morphology0.55885453
120MP0010769_abnormal_survival0.53084653
121MP0010768_mortality/aging0.49007011

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.43162174
2Myokymia (HP:0002411)4.64683453
3Atonic seizures (HP:0010819)4.63869842
4Ankle clonus (HP:0011448)4.41897449
5Action tremor (HP:0002345)4.07077624
6Diplopia (HP:0000651)3.90776253
7Abnormality of binocular vision (HP:0011514)3.90776253
8Focal seizures (HP:0007359)3.80353725
9Peripheral hypomyelination (HP:0007182)3.70939046
10Acute necrotizing encephalopathy (HP:0006965)3.59139298
11Obstructive sleep apnea (HP:0002870)3.56321679
12Febrile seizures (HP:0002373)3.55790568
13Hyperventilation (HP:0002883)3.52279298
14Megalencephaly (HP:0001355)3.40215470
15Retinal dysplasia (HP:0007973)3.35651826
16Epileptic encephalopathy (HP:0200134)3.34432700
17Absence seizures (HP:0002121)3.34181099
18Abnormal hair whorl (HP:0010721)3.32337192
19Dialeptic seizures (HP:0011146)3.25443217
20Urinary bladder sphincter dysfunction (HP:0002839)3.22962250
21Visual hallucinations (HP:0002367)3.16837153
22Protruding tongue (HP:0010808)3.14915758
23Annular pancreas (HP:0001734)3.12858952
24Insomnia (HP:0100785)3.06984234
25Progressive cerebellar ataxia (HP:0002073)3.00318633
26Progressive macrocephaly (HP:0004481)2.97695414
27Abnormal mitochondria in muscle tissue (HP:0008316)2.92555361
28Septo-optic dysplasia (HP:0100842)2.92095989
29Abnormality of the labia minora (HP:0012880)2.89967014
30Polyphagia (HP:0002591)2.89442075
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.85714272
32Absent/shortened dynein arms (HP:0200106)2.85714272
33Mitochondrial inheritance (HP:0001427)2.84564644
34Turricephaly (HP:0000262)2.80676372
35Generalized tonic-clonic seizures (HP:0002069)2.79243170
36Intention tremor (HP:0002080)2.77328128
37Hemiplegia (HP:0002301)2.74348844
38Acute encephalopathy (HP:0006846)2.73586031
39Amblyopia (HP:0000646)2.70335799
40Papilledema (HP:0001085)2.69064763
41Poor suck (HP:0002033)2.66559165
42Delusions (HP:0000746)2.63224935
43Abnormality of the corticospinal tract (HP:0002492)2.62601003
44Urinary urgency (HP:0000012)2.61687279
45Broad-based gait (HP:0002136)2.60402769
46Abnormal respiratory motile cilium morphology (HP:0005938)2.60379954
47Abnormal respiratory epithelium morphology (HP:0012253)2.60379954
48Torticollis (HP:0000473)2.59428835
49Akinesia (HP:0002304)2.58952074
50Increased circulating renin level (HP:0000848)2.52927967
51Truncal ataxia (HP:0002078)2.50643880
52Optic disc pallor (HP:0000543)2.48401902
53Esotropia (HP:0000565)2.47523721
54Cerebral inclusion bodies (HP:0100314)2.45023866
55Status epilepticus (HP:0002133)2.44751172
56Abnormal ciliary motility (HP:0012262)2.44434693
57Impaired vibration sensation in the lower limbs (HP:0002166)2.42907963
58Dysmetria (HP:0001310)2.41998076
59Depression (HP:0000716)2.41496326
60Postural instability (HP:0002172)2.40655504
61Aplasia involving bones of the upper limbs (HP:0009823)2.39713795
62Aplasia of the phalanges of the hand (HP:0009802)2.39713795
63Aplasia involving bones of the extremities (HP:0009825)2.39713795
64Neurofibrillary tangles (HP:0002185)2.36184028
65Increased CSF lactate (HP:0002490)2.34392197
66Sleep apnea (HP:0010535)2.33642552
67Hyperacusis (HP:0010780)2.32320947
68Split foot (HP:0001839)2.31796838
69Abnormality of the axillary hair (HP:0100134)2.31407073
70Abnormality of secondary sexual hair (HP:0009888)2.31407073
71Overriding aorta (HP:0002623)2.29976974
72Mutism (HP:0002300)2.28789734
73Generalized myoclonic seizures (HP:0002123)2.28461792
74Morphological abnormality of the inner ear (HP:0011390)2.26679110
75Focal dystonia (HP:0004373)2.24406960
76Optic nerve hypoplasia (HP:0000609)2.23873636
77Elfin facies (HP:0004428)2.23845866
78Lower limb muscle weakness (HP:0007340)2.22583616
79Gait imbalance (HP:0002141)2.20624403
80Cerebral hypomyelination (HP:0006808)2.19339121
81Medial flaring of the eyebrow (HP:0010747)2.17273921
82Excessive salivation (HP:0003781)2.15002288
83Drooling (HP:0002307)2.15002288
84Clonus (HP:0002169)2.14817820
85Abnormal eating behavior (HP:0100738)2.14020943
86Hyperthyroidism (HP:0000836)2.13907842
87EEG with generalized epileptiform discharges (HP:0011198)2.13763622
88Nasal speech (HP:0001611)2.13521405
89Sensory axonal neuropathy (HP:0003390)2.11674356
90Increased hepatocellular lipid droplets (HP:0006565)2.11517632
91Partial agenesis of the corpus callosum (HP:0001338)2.08852530
92Scanning speech (HP:0002168)2.08787572
93Poor eye contact (HP:0000817)2.07554151
94Leukodystrophy (HP:0002415)2.07123817
95Supranuclear gaze palsy (HP:0000605)2.06933652
96Hepatocellular necrosis (HP:0001404)2.05148955
97Absent speech (HP:0001344)2.04044315
98Stereotypic behavior (HP:0000733)2.03770656
99Hypsarrhythmia (HP:0002521)2.03392091
100Abnormal social behavior (HP:0012433)2.01491076
101Impaired social interactions (HP:0000735)2.01491076
102Narrow nasal bridge (HP:0000446)2.01432069
103Pointed chin (HP:0000307)2.01384745
104CNS hypomyelination (HP:0003429)2.00430079
105Craniofacial dystonia (HP:0012179)2.00324917
106Degeneration of the lateral corticospinal tracts (HP:0002314)2.00234725
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00234725
108Abnormal respiratory motile cilium physiology (HP:0012261)1.99196010
109Congenital primary aphakia (HP:0007707)1.97737279
110Renal Fanconi syndrome (HP:0001994)1.97059349
111Tetraplegia (HP:0002445)1.96450365
112Bundle branch block (HP:0011710)1.95869056
113Foot dorsiflexor weakness (HP:0009027)1.95312174
114Epileptiform EEG discharges (HP:0011182)1.94657378
115Gastroesophageal reflux (HP:0002020)1.94606629
116Absent septum pellucidum (HP:0001331)1.93694673
117Rigidity (HP:0002063)1.92071332
118Spastic tetraparesis (HP:0001285)1.91521342
119Hypoplasia of the corpus callosum (HP:0002079)1.91280035
120Type II lissencephaly (HP:0007260)1.90640854
121Neuronal loss in central nervous system (HP:0002529)1.89727875
122Bradykinesia (HP:0002067)1.87373760
123Dysdiadochokinesis (HP:0002075)1.86908939
124Bowel incontinence (HP:0002607)1.85370374
125Fetal akinesia sequence (HP:0001989)1.84968487
126Gaze-evoked nystagmus (HP:0000640)1.84796915
127Limb dystonia (HP:0002451)1.84589571
128Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83575458
129Hypoplastic female external genitalia (HP:0012815)1.83290390
130Failure to thrive in infancy (HP:0001531)1.83043223
131Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82039724
132Abnormality of midbrain morphology (HP:0002418)1.81033787
133Molar tooth sign on MRI (HP:0002419)1.81033787
134Genital tract atresia (HP:0001827)1.80860471
135Parakeratosis (HP:0001036)1.80777408
136Abnormality of the foot musculature (HP:0001436)1.80439707
137Spastic gait (HP:0002064)1.79872112
138Abnormality of the diencephalon (HP:0010662)1.79521493
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78769426
140Abnormality of the aortic arch (HP:0012303)1.78504445
141Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.78476155
142Unsteady gait (HP:0002317)1.78405545
143Spinal canal stenosis (HP:0003416)1.77929859
144Abnormality of cochlea (HP:0000375)1.76929646
145Hemiparesis (HP:0001269)1.76821691
146Renovascular hypertension (HP:0100817)1.76670192
147Lower limb asymmetry (HP:0100559)1.76563073
148Choreoathetosis (HP:0001266)1.76546993
149Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76432887
150Vaginal atresia (HP:0000148)1.76432174
151Specific learning disability (HP:0001328)1.76133983
152Anxiety (HP:0000739)1.75916404
153Nephrogenic diabetes insipidus (HP:0009806)1.75825310
154Hypoventilation (HP:0002791)1.75085534
155Abnormality of the septum pellucidum (HP:0007375)1.74316527
156Hypoplasia of the brainstem (HP:0002365)1.72901171
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72901171
158Abnormality of the lower motor neuron (HP:0002366)1.71970634
159Psychosis (HP:0000709)1.70319877
160Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69763553
161Testicular atrophy (HP:0000029)1.68947453
162Spastic tetraplegia (HP:0002510)1.68364376
163Labial hypoplasia (HP:0000066)1.68053907
164Myotonia (HP:0002486)1.67913277
165Rapidly progressive (HP:0003678)1.67081565
166Abnormality of glycolysis (HP:0004366)1.67064604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.28198497
2CASK3.86628267
3NTRK33.70767425
4PNCK3.59996959
5PRKD33.27308126
6TNIK2.76856182
7CAMKK12.26377274
8PLK22.18511508
9MAP3K92.13621707
10NTRK21.98397285
11MARK11.97815097
12MAP2K71.96816448
13MINK11.87913825
14NME11.87819683
15MAP3K41.68143939
16RIPK11.66945199
17GRK71.62731002
18ARAF1.62034819
19MAPK131.47306527
20OXSR11.44937951
21CDK191.44240627
22GRK51.43529836
23PINK11.43236389
24STK161.43219906
25MAP3K121.40297997
26FES1.39576617
27CAMK2B1.38094366
28CAMK2A1.35964994
29MKNK21.35818617
30UHMK11.33999759
31RIPK41.33439341
32STK391.33390228
33SIK21.33147128
34FGR1.30564654
35PRKCG1.22661404
36BRAF1.20668490
37PHKG21.20555522
38PHKG11.20555522
39MAPK121.17534666
40PRPF4B1.15301791
41BMPR21.09923445
42CLK11.06739844
43MAP2K41.05909998
44PRKCH1.05867033
45FGFR21.04884632
46DYRK1A1.04302874
47MARK20.99534341
48TNK20.99314162
49GRK60.97654778
50SGK20.94639274
51CDK50.93808076
52PKN10.91861955
53ADRBK20.91426332
54LIMK10.87841106
55SGK30.85579223
56ICK0.83805259
57NTRK10.83280909
58CAMK2D0.82930820
59TYRO30.82871115
60BRSK10.81304580
61ADRBK10.80663104
62CAMK2G0.76881452
63CDK140.75945355
64CSNK1G20.74719037
65DYRK20.74375788
66MKNK10.74368662
67CDK180.73486649
68CDK11A0.72767248
69MAP3K110.72672743
70CDK150.72562695
71BUB10.71978538
72ALK0.71784958
73IRAK20.70548252
74KSR10.70384672
75MUSK0.69739037
76DAPK20.68863116
77DAPK10.68630068
78KSR20.68598010
79CAMKK20.68393148
80ROCK20.67402016
81NEK60.66961331
82TLK10.66341837
83CAMK40.66313086
84BCR0.64768404
85CSNK1E0.63860879
86AKT30.63578613
87STK380.62960429
88TRIB30.61983426
89PRKCE0.61852169
90PAK60.60274355
91TAOK20.59020086
92WNK40.56981131
93MAP3K130.56907383
94PRKCZ0.56429255
95PRKACA0.55759477
96CAMK10.55587071
97DDR20.55415499
98DYRK1B0.54788202
99MAPKAPK50.54328965
100RPS6KA30.54160131
101MAPK40.54062328
102ROCK10.53498175
103SGK2230.53430704
104SGK4940.53430704
105PLK30.53204357
106RPS6KA20.52714307
107PTK2B0.52239769
108CAMK1D0.51700192
109DAPK30.50786259
110MAP2K60.49696968
111ERBB20.47862378
112IRAK10.47333590
113CSNK1G30.44681365
114BLK0.44022039
115WNK10.42520314
116PRKCI0.41944271
117SGK10.41898803
118BRD40.41127505
119TSSK60.40316238
120LATS20.39990099
121WEE10.38988645
122RET0.38625016
123DMPK0.37613307
124GRK10.36638291
125SMG10.36603648
126TESK10.36424898
127PDPK10.36103215
128PRKG10.35841181
129CAMK1G0.35604126
130LMTK20.35433770
131PAK30.35404631
132MAPK80.35387923
133CSNK1G10.35137386
134PRKD10.35072547
135FYN0.34283853
136STK110.34237802
137CSNK1A1L0.34026502
138ABL20.33738201
139CSNK1A10.33193538
140MAPK100.32345750
141CSNK2A20.31759657

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.67483558
2Oxidative phosphorylation_Homo sapiens_hsa001903.66077010
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.86446337
4Parkinsons disease_Homo sapiens_hsa050122.79468579
5Glutamatergic synapse_Homo sapiens_hsa047242.55468567
6Alzheimers disease_Homo sapiens_hsa050102.54473587
7Synaptic vesicle cycle_Homo sapiens_hsa047212.53709087
8GABAergic synapse_Homo sapiens_hsa047272.43972124
9Taste transduction_Homo sapiens_hsa047422.39160877
10Collecting duct acid secretion_Homo sapiens_hsa049662.39002917
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.38323873
12Long-term potentiation_Homo sapiens_hsa047202.34615090
13Morphine addiction_Homo sapiens_hsa050322.33987599
14Circadian entrainment_Homo sapiens_hsa047132.28422173
15Amphetamine addiction_Homo sapiens_hsa050312.25756785
16Huntingtons disease_Homo sapiens_hsa050162.15025021
17Serotonergic synapse_Homo sapiens_hsa047262.12004551
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00158875
19Long-term depression_Homo sapiens_hsa047301.93049894
20Cardiac muscle contraction_Homo sapiens_hsa042601.91162874
21Dopaminergic synapse_Homo sapiens_hsa047281.90035493
22Salivary secretion_Homo sapiens_hsa049701.71876281
23Axon guidance_Homo sapiens_hsa043601.71355609
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65701451
25Cocaine addiction_Homo sapiens_hsa050301.60797973
26Calcium signaling pathway_Homo sapiens_hsa040201.55212119
27Olfactory transduction_Homo sapiens_hsa047401.51983392
28Vibrio cholerae infection_Homo sapiens_hsa051101.51723844
29Cholinergic synapse_Homo sapiens_hsa047251.47485440
30RNA polymerase_Homo sapiens_hsa030201.41889935
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.38017302
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33406134
33Phototransduction_Homo sapiens_hsa047441.30547093
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30306647
35Vitamin B6 metabolism_Homo sapiens_hsa007501.26618770
36Insulin secretion_Homo sapiens_hsa049111.26172931
37Oxytocin signaling pathway_Homo sapiens_hsa049211.24735438
38Renin secretion_Homo sapiens_hsa049241.23370888
39Bile secretion_Homo sapiens_hsa049761.20492230
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19494503
41Gastric acid secretion_Homo sapiens_hsa049711.12466685
42Gap junction_Homo sapiens_hsa045401.11345723
43Glioma_Homo sapiens_hsa052141.09860187
44Proteasome_Homo sapiens_hsa030501.06285179
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02000984
46GnRH signaling pathway_Homo sapiens_hsa049121.00230919
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00058200
48Melanogenesis_Homo sapiens_hsa049160.98970385
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97135045
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93868351
51Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92307697
52Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91685467
53Arginine and proline metabolism_Homo sapiens_hsa003300.90653305
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88885796
55cAMP signaling pathway_Homo sapiens_hsa040240.88419659
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86847475
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86225582
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86196939
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.83578524
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82881282
61Ether lipid metabolism_Homo sapiens_hsa005650.82826546
62VEGF signaling pathway_Homo sapiens_hsa043700.82187345
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80508473
64Steroid biosynthesis_Homo sapiens_hsa001000.80085696
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.78740199
66Notch signaling pathway_Homo sapiens_hsa043300.77480949
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75271235
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71586242
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70529285
70Oocyte meiosis_Homo sapiens_hsa041140.66206334
71beta-Alanine metabolism_Homo sapiens_hsa004100.66186267
72Inositol phosphate metabolism_Homo sapiens_hsa005620.65726053
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64678616
74Histidine metabolism_Homo sapiens_hsa003400.63704712
75Alcoholism_Homo sapiens_hsa050340.61545659
76Ribosome_Homo sapiens_hsa030100.60769143
77Sphingolipid metabolism_Homo sapiens_hsa006000.60471757
78Dorso-ventral axis formation_Homo sapiens_hsa043200.60252017
79Wnt signaling pathway_Homo sapiens_hsa043100.59375873
80Sulfur relay system_Homo sapiens_hsa041220.58471748
81Hippo signaling pathway_Homo sapiens_hsa043900.57740364
82Pancreatic secretion_Homo sapiens_hsa049720.56577652
83Estrogen signaling pathway_Homo sapiens_hsa049150.54617117
84Ras signaling pathway_Homo sapiens_hsa040140.54192899
85Endocytosis_Homo sapiens_hsa041440.53421140
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52483097
87Endometrial cancer_Homo sapiens_hsa052130.51510344
88Rheumatoid arthritis_Homo sapiens_hsa053230.51497923
89Type II diabetes mellitus_Homo sapiens_hsa049300.50536773
90Prion diseases_Homo sapiens_hsa050200.50507869
91Spliceosome_Homo sapiens_hsa030400.48654038
92Glucagon signaling pathway_Homo sapiens_hsa049220.47802356
93Basal cell carcinoma_Homo sapiens_hsa052170.47705149
94Fatty acid elongation_Homo sapiens_hsa000620.47287947
95MAPK signaling pathway_Homo sapiens_hsa040100.46747750
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45959429
97Melanoma_Homo sapiens_hsa052180.45778576
98Hedgehog signaling pathway_Homo sapiens_hsa043400.44334241
99Pyrimidine metabolism_Homo sapiens_hsa002400.43920438
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43514655
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42683073
102Purine metabolism_Homo sapiens_hsa002300.42677843
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42561478
104Choline metabolism in cancer_Homo sapiens_hsa052310.41586387
105Insulin signaling pathway_Homo sapiens_hsa049100.41546507
106AMPK signaling pathway_Homo sapiens_hsa041520.41484059
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41132466
108Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39388295
109Fatty acid biosynthesis_Homo sapiens_hsa000610.35217723
110Rap1 signaling pathway_Homo sapiens_hsa040150.34734944
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34606784
112ErbB signaling pathway_Homo sapiens_hsa040120.34205506
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.32884128
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32520067
115Arginine biosynthesis_Homo sapiens_hsa002200.32050073
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31164771
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.30639370
118African trypanosomiasis_Homo sapiens_hsa051430.30628223
119Protein export_Homo sapiens_hsa030600.29382641
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29060592
121Fanconi anemia pathway_Homo sapiens_hsa034600.28624022
122Ovarian steroidogenesis_Homo sapiens_hsa049130.27410093
123Dilated cardiomyopathy_Homo sapiens_hsa054140.27294450
124Metabolic pathways_Homo sapiens_hsa011000.26784524
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26527473
126Thyroid hormone synthesis_Homo sapiens_hsa049180.26318976
127Type I diabetes mellitus_Homo sapiens_hsa049400.24838559
128Linoleic acid metabolism_Homo sapiens_hsa005910.24744463
129mRNA surveillance pathway_Homo sapiens_hsa030150.24592516
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24574531
131Phagosome_Homo sapiens_hsa041450.24288756

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