GCSH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)6.60021383
2nucleobase biosynthetic process (GO:0046112)5.95301021
3mitotic metaphase plate congression (GO:0007080)5.57853570
4ribosome assembly (GO:0042255)5.42275072
5folic acid metabolic process (GO:0046655)5.06134431
6ribosome biogenesis (GO:0042254)4.88749016
7termination of RNA polymerase III transcription (GO:0006386)4.67625420
8transcription elongation from RNA polymerase III promoter (GO:0006385)4.67625420
9DNA replication checkpoint (GO:0000076)4.62853311
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.62812967
11vitamin transmembrane transport (GO:0035461)4.56431768
12rRNA modification (GO:0000154)4.53880406
13regulation of spindle organization (GO:0090224)4.49594462
14chaperone-mediated protein transport (GO:0072321)4.37185993
15metaphase plate congression (GO:0051310)4.30184787
16proteasome assembly (GO:0043248)4.18546964
17folic acid transport (GO:0015884)4.11176102
18regulation of mitochondrial translation (GO:0070129)4.09211313
19transcription elongation from RNA polymerase I promoter (GO:0006362)4.08816881
20termination of RNA polymerase I transcription (GO:0006363)4.08193891
21establishment of integrated proviral latency (GO:0075713)4.08062241
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.03719104
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03007212
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.01721991
25ATP synthesis coupled proton transport (GO:0015986)4.01721991
267-methylguanosine mRNA capping (GO:0006370)4.01209051
27formation of translation preinitiation complex (GO:0001731)4.00042022
28transcription from RNA polymerase I promoter (GO:0006360)3.99765120
297-methylguanosine RNA capping (GO:0009452)3.89835678
30RNA capping (GO:0036260)3.89835678
31ribonucleoprotein complex biogenesis (GO:0022613)3.86217484
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.80525050
33DNA deamination (GO:0045006)3.79629870
34spliceosomal snRNP assembly (GO:0000387)3.76743304
35amino acid salvage (GO:0043102)3.69171288
36L-methionine salvage (GO:0071267)3.69171288
37L-methionine biosynthetic process (GO:0071265)3.69171288
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68728104
39ribosomal small subunit biogenesis (GO:0042274)3.67299881
40maturation of SSU-rRNA (GO:0030490)3.66792210
41transcription initiation from RNA polymerase I promoter (GO:0006361)3.66670823
42rRNA methylation (GO:0031167)3.66160623
43regulation of mitotic spindle organization (GO:0060236)3.65647424
44ribosomal small subunit assembly (GO:0000028)3.65128307
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60319306
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.59809715
47rRNA processing (GO:0006364)3.58795629
48positive regulation of chromosome segregation (GO:0051984)3.51238562
49protein localization to kinetochore (GO:0034501)3.50631638
50CENP-A containing nucleosome assembly (GO:0034080)3.50611250
51rRNA metabolic process (GO:0016072)3.47908972
52serine family amino acid biosynthetic process (GO:0009070)3.46795010
53negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.46157477
54respiratory electron transport chain (GO:0022904)3.43907304
55maturation of 5.8S rRNA (GO:0000460)3.43691314
56L-serine metabolic process (GO:0006563)3.42279606
57DNA strand elongation (GO:0022616)3.41202554
58viral transcription (GO:0019083)3.40411097
59DNA replication initiation (GO:0006270)3.39952852
60* glycine metabolic process (GO:0006544)3.38663747
61translational termination (GO:0006415)3.37335038
62telomere maintenance via semi-conservative replication (GO:0032201)3.35350810
63pantothenate metabolic process (GO:0015939)3.34906673
64electron transport chain (GO:0022900)3.34057244
65spindle checkpoint (GO:0031577)3.32822511
66positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32814147
67chromatin remodeling at centromere (GO:0031055)3.32719599
68oxidative phosphorylation (GO:0006119)3.31145652
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.30962899
70pseudouridine synthesis (GO:0001522)3.30276936
71ribosomal large subunit biogenesis (GO:0042273)3.29132859
72DNA damage response, detection of DNA damage (GO:0042769)3.28731494
73GMP metabolic process (GO:0046037)3.28153143
74mitotic nuclear envelope disassembly (GO:0007077)3.27933280
75methionine metabolic process (GO:0006555)3.26813762
76establishment of chromosome localization (GO:0051303)3.26782494
77DNA-templated transcription, elongation (GO:0006354)3.26444890
78transcription elongation from RNA polymerase II promoter (GO:0006368)3.24275168
79regulation of translation in response to stress (GO:0043555)3.21723096
80SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21288144
81cotranslational protein targeting to membrane (GO:0006613)3.18910447
82mitotic spindle checkpoint (GO:0071174)3.18754382
83blastocyst development (GO:0001824)3.17909495
84attachment of spindle microtubules to kinetochore (GO:0008608)3.17546796
85L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.16773761
86positive regulation of ligase activity (GO:0051351)3.15099619
87methionine biosynthetic process (GO:0009086)3.15004090
88DNA replication-independent nucleosome assembly (GO:0006336)3.14027393
89DNA replication-independent nucleosome organization (GO:0034724)3.14027393
90transcription from mitochondrial promoter (GO:0006390)3.13218982
91lung-associated mesenchyme development (GO:0060484)3.13051934
92protein targeting to ER (GO:0045047)3.11294503
93protein targeting to mitochondrion (GO:0006626)3.11022048
94establishment of viral latency (GO:0019043)3.10844050
95sulfur amino acid biosynthetic process (GO:0000097)3.10471029
96cellular component biogenesis (GO:0044085)3.10148249
97negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09040169
98negative regulation of ligase activity (GO:0051352)3.09040169
99regulation of chromosome segregation (GO:0051983)3.07819205
100negative regulation of chromosome segregation (GO:0051985)3.06704654
101positive regulation of viral transcription (GO:0050434)3.06090026
102transcription-coupled nucleotide-excision repair (GO:0006283)3.05335381
103histone exchange (GO:0043486)3.05274669
104DNA strand elongation involved in DNA replication (GO:0006271)3.05262634
105negative regulation of mitotic sister chromatid separation (GO:2000816)3.04685278
106negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04685278
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04685278
108negative regulation of sister chromatid segregation (GO:0033046)3.04685278
109histone-serine phosphorylation (GO:0035404)3.04439134
110DNA ligation (GO:0006266)3.03896864
111membrane disassembly (GO:0030397)3.03350054
112nuclear envelope disassembly (GO:0051081)3.03350054
113DNA-dependent DNA replication (GO:0006261)3.02961500
114guanosine-containing compound biosynthetic process (GO:1901070)3.02123640
115establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01552045
116mitotic spindle assembly checkpoint (GO:0007094)3.00307390
117IMP biosynthetic process (GO:0006188)3.00081567
118S-adenosylmethionine metabolic process (GO:0046500)2.99739421
119translational elongation (GO:0006414)2.98603644
120protein localization to chromosome, centromeric region (GO:0071459)2.98301586
121cell cycle G1/S phase transition (GO:0044843)2.95916623
122G1/S transition of mitotic cell cycle (GO:0000082)2.95916623
123regulation of double-strand break repair via homologous recombination (GO:0010569)2.95058417
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94532549
125spindle assembly checkpoint (GO:0071173)2.94191927
126protein localization to endoplasmic reticulum (GO:0070972)2.94155419
127translation (GO:0006412)2.93807350
128protein neddylation (GO:0045116)2.93800460
129kinetochore organization (GO:0051383)2.91202559
130cullin deneddylation (GO:0010388)2.90877578
131IMP metabolic process (GO:0046040)2.90211535
132translational initiation (GO:0006413)2.89888096
133protein localization to mitochondrion (GO:0070585)2.89252420
134establishment of protein localization to mitochondrion (GO:0072655)2.88766345
135nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86643941
136mitochondrial respiratory chain complex I assembly (GO:0032981)2.84895991
137NADH dehydrogenase complex assembly (GO:0010257)2.84895991
138mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84895991
139mitochondrial respiratory chain complex assembly (GO:0033108)2.78964836
140telomere maintenance via recombination (GO:0000722)2.76554472
141kinetochore assembly (GO:0051382)2.75245183
142protein complex biogenesis (GO:0070271)2.74491669
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70215600
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70144973
145mitotic recombination (GO:0006312)2.69818169
146inner mitochondrial membrane organization (GO:0007007)2.68683407
147DNA replication-dependent nucleosome assembly (GO:0006335)2.67849307
148DNA replication-dependent nucleosome organization (GO:0034723)2.67849307
149protein deneddylation (GO:0000338)2.64556325
150mitotic sister chromatid segregation (GO:0000070)2.62579938
151DNA double-strand break processing (GO:0000729)2.62188904
152viral life cycle (GO:0019058)2.61444825
153cellular protein complex disassembly (GO:0043624)2.61139563
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.61043037
155regulation of helicase activity (GO:0051095)2.58643326
156termination of RNA polymerase II transcription (GO:0006369)2.58439221
157DNA unwinding involved in DNA replication (GO:0006268)2.58326889
158pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.56360504
159ATP-dependent chromatin remodeling (GO:0043044)2.53596910
160histone mRNA metabolic process (GO:0008334)2.52472782
161pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.52199866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60571620
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.77747121
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.17704876
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.05926598
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66638814
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49694263
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.44658617
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.41480306
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.23962393
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.21451928
11* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15114891
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.05571219
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97854048
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88937046
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85069281
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63242832
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59621545
18AR_21909140_ChIP-Seq_LNCAP_Human2.54278420
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42245425
20VDR_23849224_ChIP-Seq_CD4+_Human2.39573994
21* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32719600
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28158437
23XRN2_22483619_ChIP-Seq_HELA_Human2.27807500
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16468147
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13456445
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.11688382
27GABP_19822575_ChIP-Seq_HepG2_Human2.10810919
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.04857890
29NANOG_18555785_ChIP-Seq_MESCs_Mouse2.03183808
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02870855
31DCP1A_22483619_ChIP-Seq_HELA_Human2.02841058
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99019735
33FOXP3_21729870_ChIP-Seq_TREG_Human1.90146047
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85402560
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.82018071
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76309273
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74697677
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70508581
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68180938
40TTF2_22483619_ChIP-Seq_HELA_Human1.61938387
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.60769473
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59136858
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57171985
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55070369
45KDM5A_27292631_Chip-Seq_BREAST_Human1.54162707
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.53775456
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.53409941
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52102181
49MYC_18940864_ChIP-ChIP_HL60_Human1.52021287
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48607696
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48449288
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48331724
53ELK1_19687146_ChIP-ChIP_HELA_Human1.44243669
54* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41914188
55ZNF263_19887448_ChIP-Seq_K562_Human1.41814852
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.40325063
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39723453
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38246017
59* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35592263
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32305710
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27747318
62SOX2_16153702_ChIP-ChIP_HESCs_Human1.26210562
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25394017
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23706495
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.23693147
66ELK1_22589737_ChIP-Seq_MCF10A_Human1.20546997
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20447887
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18670628
69EWS_26573619_Chip-Seq_HEK293_Human1.17014019
70NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.16817763
71* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12521302
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10295145
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10088590
74TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09602446
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09300272
76SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08502021
77KAP1_22055183_ChIP-Seq_ESCs_Mouse1.07708036
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.06858656
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05334169
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04535177
81* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03627066
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02833513
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02634739
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01469586
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.00071522
86NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99975018
87KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98792359
88NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98288145
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97650554
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97356385
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97148177
92CIITA_25753668_ChIP-Seq_RAJI_Human0.97037661
93FUS_26573619_Chip-Seq_HEK293_Human0.96975776
94NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96042072
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95656499
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94932875
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94509596
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.94387349
99* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94029529
100RXR_22158963_ChIP-Seq_LIVER_Mouse0.93891983
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92661557
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91991648
103PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91707288
104* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91363736
105CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91217974
106TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90733951
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90575314
108OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90515263
109EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90173819
110TP63_19390658_ChIP-ChIP_HaCaT_Human0.88821414
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87427324
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.86224411
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.85582015
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85324190
115CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.78942714
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78353726
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.72353929
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72274815
119ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.72227806
120IGF1R_20145208_ChIP-Seq_DFB_Human0.71850909
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70462236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.29969150
2MP0003111_abnormal_nucleus_morphology4.39790167
3MP0004957_abnormal_blastocyst_morpholog4.24343917
4MP0003718_maternal_effect4.13034607
5MP0010094_abnormal_chromosome_stability3.66617469
6MP0003077_abnormal_cell_cycle3.43173691
7MP0008057_abnormal_DNA_replication2.93145996
8MP0003123_paternal_imprinting2.92427204
9MP0003806_abnormal_nucleotide_metabolis2.86472795
10MP0008260_abnormal_autophagy2.82257158
11MP0008058_abnormal_DNA_repair2.80089278
12MP0002139_abnormal_hepatobiliary_system2.75029570
13MP0009840_abnormal_foam_cell2.70994190
14MP0008932_abnormal_embryonic_tissue2.39349701
15MP0001730_embryonic_growth_arrest2.38819451
16MP0005365_abnormal_bile_salt2.37399672
17MP0003786_premature_aging2.35937247
18MP0001529_abnormal_vocalization2.33276587
19MP0005360_urolithiasis2.23267422
20MP0008007_abnormal_cellular_replicative2.17014912
21MP0005085_abnormal_gallbladder_physiolo2.12500552
22MP0009379_abnormal_foot_pigmentation1.96490951
23MP0005332_abnormal_amino_acid1.89342932
24MP0002938_white_spotting1.84735971
25MP0010030_abnormal_orbit_morphology1.81273532
26MP0001661_extended_life_span1.80046491
27MP0001672_abnormal_embryogenesis/_devel1.79167725
28MP0005380_embryogenesis_phenotype1.79167725
29MP0000350_abnormal_cell_proliferation1.73164349
30MP0005451_abnormal_body_composition1.67491426
31MP0008789_abnormal_olfactory_epithelium1.66935039
32MP0000566_synostosis1.59989830
33MP0003186_abnormal_redox_activity1.59756838
34MP0003890_abnormal_embryonic-extraembry1.57346384
35MP0004019_abnormal_vitamin_homeostasis1.54366713
36MP0003984_embryonic_growth_retardation1.52175681
37MP0001764_abnormal_homeostasis1.51008029
38MP0000537_abnormal_urethra_morphology1.50291126
39MP0005395_other_phenotype1.50196524
40MP0002088_abnormal_embryonic_growth/wei1.49286227
41MP0001697_abnormal_embryo_size1.49058752
42MP0002697_abnormal_eye_size1.48870131
43MP0006036_abnormal_mitochondrial_physio1.48814324
44MP0003221_abnormal_cardiomyocyte_apopto1.48757508
45MP0002080_prenatal_lethality1.45476477
46MP0000049_abnormal_middle_ear1.44920863
47MP0010307_abnormal_tumor_latency1.41253130
48MP0005499_abnormal_olfactory_system1.39461215
49MP0005394_taste/olfaction_phenotype1.39461215
50MP0008877_abnormal_DNA_methylation1.36402699
51MP0003878_abnormal_ear_physiology1.33895887
52MP0005377_hearing/vestibular/ear_phenot1.33895887
53MP0006035_abnormal_mitochondrial_morpho1.31867027
54MP0003567_abnormal_fetal_cardiomyocyte1.31852570
55MP0002234_abnormal_pharynx_morphology1.31127739
56MP0009672_abnormal_birth_weight1.30772527
57MP0008875_abnormal_xenobiotic_pharmacok1.30106342
58MP0003315_abnormal_perineum_morphology1.29975525
59MP0002210_abnormal_sex_determination1.29166898
60MP0001286_abnormal_eye_development1.27290313
61MP0002233_abnormal_nose_morphology1.25935225
62MP0006072_abnormal_retinal_apoptosis1.23287402
63MP0002396_abnormal_hematopoietic_system1.23190784
64MP0000750_abnormal_muscle_regeneration1.21153507
65MP0001188_hyperpigmentation1.20991596
66MP0001542_abnormal_bone_strength1.20740748
67MP0004133_heterotaxia1.20667075
68MP0002085_abnormal_embryonic_tissue1.18038125
69MP0001145_abnormal_male_reproductive1.17291444
70MP0009333_abnormal_splenocyte_physiolog1.15824727
71MP0003122_maternal_imprinting1.15777048
72MP0003121_genomic_imprinting1.15710144
73MP0000631_abnormal_neuroendocrine_gland1.13832384
74MP0010329_abnormal_lipoprotein_level1.13625887
75MP0005187_abnormal_penis_morphology1.12471781
76MP0002090_abnormal_vision1.10361601
77MP0002111_abnormal_tail_morphology1.09737535
78MP0002736_abnormal_nociception_after1.09008228
79MP0001984_abnormal_olfaction1.08235583
80MP0000579_abnormal_nail_morphology1.07917921
81MP0009697_abnormal_copulation1.07487175
82MP0002086_abnormal_extraembryonic_tissu1.07485576
83MP0001346_abnormal_lacrimal_gland1.05940826
84MP0000653_abnormal_sex_gland1.05760385
85MP0000778_abnormal_nervous_system1.05058795
86MP0003011_delayed_dark_adaptation1.03117465
87MP0003942_abnormal_urinary_system1.02103232
88MP0002132_abnormal_respiratory_system1.01997894
89MP0001929_abnormal_gametogenesis1.01556931
90MP0000647_abnormal_sebaceous_gland1.00803873
91MP0000358_abnormal_cell_content/0.99946927
92MP0003880_abnormal_central_pattern0.99046583
93MP0002084_abnormal_developmental_patter0.97853823
94MP0000609_abnormal_liver_physiology0.96527198
95MP0005646_abnormal_pituitary_gland0.96473565
96MP0003755_abnormal_palate_morphology0.96444394
97MP0001485_abnormal_pinna_reflex0.96166338
98MP0005319_abnormal_enzyme/_coenzyme0.96046452
99MP0002092_abnormal_eye_morphology0.95661615
100MP0003861_abnormal_nervous_system0.95436815
101MP0003938_abnormal_ear_development0.94346004
102MP0000313_abnormal_cell_death0.92937348
103MP0000762_abnormal_tongue_morphology0.90747987
104MP0002160_abnormal_reproductive_system0.90434711
105MP0001299_abnormal_eye_distance/0.88293732
106MP0001756_abnormal_urination0.87846841
107MP0005389_reproductive_system_phenotype0.87430212
108MP0005391_vision/eye_phenotype0.86347449
109MP0005248_abnormal_Harderian_gland0.84893218
110MP0006292_abnormal_olfactory_placode0.83766975
111MP0003385_abnormal_body_wall0.83547183
112MP0002751_abnormal_autonomic_nervous0.83033289
113MP0003656_abnormal_erythrocyte_physiolo0.82991645
114MP0001293_anophthalmia0.80893917
115MP0001119_abnormal_female_reproductive0.79719362
116MP0004197_abnormal_fetal_growth/weight/0.79648726
117MP0003699_abnormal_female_reproductive0.77765627
118MP0009250_abnormal_appendicular_skeleto0.76195538
119MP0005253_abnormal_eye_physiology0.75891953
120MP0003941_abnormal_skin_development0.74248929
121MP0002653_abnormal_ependyma_morphology0.73551904
122MP0009703_decreased_birth_body0.73461916
123MP0004147_increased_porphyrin_level0.73056098
124MP0000598_abnormal_liver_morphology0.72097199
125MP0005266_abnormal_metabolism0.71103537
126MP0002019_abnormal_tumor_incidence0.70676639
127MP0005220_abnormal_exocrine_pancreas0.69906219
128MP0003119_abnormal_digestive_system0.69709804
129MP0003937_abnormal_limbs/digits/tail_de0.68933937
130MP0005397_hematopoietic_system_phenotyp0.68730648
131MP0001545_abnormal_hematopoietic_system0.68730648
132MP0002752_abnormal_somatic_nervous0.67558247
133MP0000026_abnormal_inner_ear0.67323601
134MP0006276_abnormal_autonomic_nervous0.66959731
135MP0009053_abnormal_anal_canal0.66786102
136MP0000428_abnormal_craniofacial_morphol0.66765530
137MP0005384_cellular_phenotype0.66174861
138MP0000747_muscle_weakness0.65889324
139MP0003136_yellow_coat_color0.64996116
140MP0004084_abnormal_cardiac_muscle0.64807673
141MP0005621_abnormal_cell_physiology0.62111450
142MP0005408_hypopigmentation0.61794071
143MP0002127_abnormal_cardiovascular_syste0.61586125
144MP0002161_abnormal_fertility/fecundity0.61005752
145MP0002269_muscular_atrophy0.60667856
146MP0002118_abnormal_lipid_homeostasis0.60000081
147MP0009643_abnormal_urine_homeostasis0.59968563
148MP0001666_abnormal_nutrient_absorption0.59778437
149MP0000627_abnormal_mammary_gland0.59150035
150MP0003936_abnormal_reproductive_system0.57209101
151MP0003195_calcinosis0.56937548

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.00740722
2Breast hypoplasia (HP:0003187)5.02001982
3Cerebral hypomyelination (HP:0006808)4.52870838
4Carpal bone hypoplasia (HP:0001498)4.20148767
5Rough bone trabeculation (HP:0100670)4.09320761
6Acute necrotizing encephalopathy (HP:0006965)4.08241112
7Gout (HP:0001997)3.96160934
8Abnormal mitochondria in muscle tissue (HP:0008316)3.83334055
9Acute encephalopathy (HP:0006846)3.79057080
10* Hyperglycinemia (HP:0002154)3.65569678
11Multiple enchondromatosis (HP:0005701)3.53889291
12Patellar aplasia (HP:0006443)3.40186598
13* Hyperglycinuria (HP:0003108)3.39877407
14Increased hepatocellular lipid droplets (HP:0006565)3.39162544
15Ureteral duplication (HP:0000073)3.35607016
16Aplasia/Hypoplasia of the patella (HP:0006498)3.34909980
17* Abnormality of serine family amino acid metabolism (HP:0010894)3.34691407
18* Abnormality of glycine metabolism (HP:0010895)3.34691407
19Megaloblastic anemia (HP:0001889)3.29964987
20Mitochondrial inheritance (HP:0001427)3.27243942
21Progressive macrocephaly (HP:0004481)3.24442797
22Reticulocytopenia (HP:0001896)3.23369654
23Oral leukoplakia (HP:0002745)3.23264222
24Progressive muscle weakness (HP:0003323)3.17618116
25Increased CSF lactate (HP:0002490)3.16223774
26Secondary amenorrhea (HP:0000869)3.12553141
27Lipid accumulation in hepatocytes (HP:0006561)3.09236097
28* Abnormality of serum amino acid levels (HP:0003112)3.07589208
29Cerebral edema (HP:0002181)3.05415385
30Abnormal trabecular bone morphology (HP:0100671)3.03789996
31Abnormality of the umbilical cord (HP:0010881)3.02435145
32Degeneration of anterior horn cells (HP:0002398)2.96267003
33Abnormality of the anterior horn cell (HP:0006802)2.96267003
34Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.93636578
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.92218119
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.92218119
37CNS hypomyelination (HP:0003429)2.89599219
38Entropion (HP:0000621)2.88620335
39Colon cancer (HP:0003003)2.85762778
40Hepatocellular necrosis (HP:0001404)2.80417525
41Abnormality of the labia minora (HP:0012880)2.78223525
42Tetraplegia (HP:0002445)2.77844029
43Premature ovarian failure (HP:0008209)2.75180467
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74556260
45Abnormality of alanine metabolism (HP:0010916)2.74556260
46Hyperalaninemia (HP:0003348)2.74556260
47Sparse eyelashes (HP:0000653)2.62452499
48Microretrognathia (HP:0000308)2.61595526
49Absent radius (HP:0003974)2.60848071
50Hepatic necrosis (HP:0002605)2.57406770
51CNS demyelination (HP:0007305)2.56899867
52Atrioventricular block (HP:0001678)2.52895390
53Abnormal spermatogenesis (HP:0008669)2.49901521
54Septo-optic dysplasia (HP:0100842)2.48522378
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47524255
56Abnormality of pyrimidine metabolism (HP:0004353)2.47405915
57Aplasia/Hypoplasia involving the musculature (HP:0001460)2.46548241
58Increased serum pyruvate (HP:0003542)2.44541658
59Abnormality of glycolysis (HP:0004366)2.44541658
60Hypobetalipoproteinemia (HP:0003563)2.44485936
61Areflexia of lower limbs (HP:0002522)2.44447183
62Absent forearm bone (HP:0003953)2.42799860
63Aplasia involving forearm bones (HP:0009822)2.42799860
64Irregular epiphyses (HP:0010582)2.37320275
65Increased intramyocellular lipid droplets (HP:0012240)2.36536852
66Lactic acidosis (HP:0003128)2.35616252
67Delusions (HP:0000746)2.35208907
68Leukodystrophy (HP:0002415)2.32898269
69Macrocytic anemia (HP:0001972)2.32389644
70Hypoplasia of the capital femoral epiphysis (HP:0003090)2.31704099
71Exercise intolerance (HP:0003546)2.30242605
72* Lethargy (HP:0001254)2.28394438
73Nausea (HP:0002018)2.28276675
74Horseshoe kidney (HP:0000085)2.28130843
75Microvesicular hepatic steatosis (HP:0001414)2.27962229
76Renal Fanconi syndrome (HP:0001994)2.26138223
77Meckel diverticulum (HP:0002245)2.25611448
78Aplasia/Hypoplasia of the uvula (HP:0010293)2.24852262
79Abnormality of the preputium (HP:0100587)2.19710718
80Trismus (HP:0000211)2.18909736
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18102049
82Abnormalities of placenta or umbilical cord (HP:0001194)2.17866064
83* Death in infancy (HP:0001522)2.17346621
84Hyperuricemia (HP:0002149)2.16820154
85Increased purine levels (HP:0004368)2.16820154
86Abnormal lung lobation (HP:0002101)2.16080850
87Triphalangeal thumb (HP:0001199)2.12967500
88Hyperammonemia (HP:0001987)2.11286013
89Abnormality of methionine metabolism (HP:0010901)2.10509087
90Congenital, generalized hypertrichosis (HP:0004540)2.10487665
91Hyperglycemia (HP:0003074)2.09212662
92Exercise-induced muscle cramps (HP:0003710)2.09097937
93Cortical dysplasia (HP:0002539)2.07377506
94Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05716818
95* Impulsivity (HP:0100710)2.04447019
96Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04167508
97Abnormality of the ileum (HP:0001549)2.03677431
98Prolonged neonatal jaundice (HP:0006579)2.02986501
99Muscle fiber splitting (HP:0003555)2.00529807
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99554425
101Dicarboxylic aciduria (HP:0003215)1.99554425
102Respiratory failure (HP:0002878)1.99362925
103Breast aplasia (HP:0100783)1.98936444
104Spastic paraparesis (HP:0002313)1.98619673
105Glossoptosis (HP:0000162)1.96677553
106Increased serum lactate (HP:0002151)1.95701928
107Stillbirth (HP:0003826)1.95435091
108Postnatal microcephaly (HP:0005484)1.95398201
109Abnormality of cells of the erythroid lineage (HP:0012130)1.93179391
110Abnormality of chromosome stability (HP:0003220)1.93143539
111Abnormality of the distal phalanges of the toes (HP:0010182)1.92457056
112Personality changes (HP:0000751)1.92366065
113Increased muscle lipid content (HP:0009058)1.91913606
114Brittle hair (HP:0002299)1.91375899
115Type I transferrin isoform profile (HP:0003642)1.90955912
116Selective tooth agenesis (HP:0001592)1.90736510
117Premature graying of hair (HP:0002216)1.90380734
1183-Methylglutaconic aciduria (HP:0003535)1.90329222
119Bone marrow hypocellularity (HP:0005528)1.90269333
120Chromsome breakage (HP:0040012)1.89947929
121Oligodactyly (hands) (HP:0001180)1.89073410
122Abnormal cartilage morphology (HP:0002763)1.89001197
123Azoospermia (HP:0000027)1.88348942
124Abnormality of fatty-acid metabolism (HP:0004359)1.88339824
125Abnormal number of erythroid precursors (HP:0012131)1.87910789
126Oligodactyly (HP:0012165)1.87822048
127Unsteady gait (HP:0002317)1.87561374
128Absent septum pellucidum (HP:0001331)1.86908053
129Patent foramen ovale (HP:0001655)1.85317690
130Reduced antithrombin III activity (HP:0001976)1.84905044
131Hypoplastic pelvis (HP:0008839)1.84804225
132Cellular immunodeficiency (HP:0005374)1.83103946
133Aplasia/Hypoplasia of the breasts (HP:0010311)1.82310710
134Abnormality of nucleobase metabolism (HP:0010932)1.81574814
135Split foot (HP:0001839)1.81324697
136Capillary hemangiomas (HP:0005306)1.80304119
137Maternal diabetes (HP:0009800)1.75539030
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71578633
139Optic disc pallor (HP:0000543)1.71407499
140Anophthalmia (HP:0000528)1.71011498
141Respiratory difficulties (HP:0002880)1.70797722
142Sclerocornea (HP:0000647)1.68399731
143Myokymia (HP:0002411)1.67984604
144Bifid tongue (HP:0010297)1.67603340
145Abnormal number of incisors (HP:0011064)1.66330643
146Duplication of thumb phalanx (HP:0009942)1.65391891
147Pallor (HP:0000980)1.64966528
148Hemivertebrae (HP:0002937)1.64766774
149Facial cleft (HP:0002006)1.62629678
150Partial duplication of thumb phalanx (HP:0009944)1.62436033
151Methylmalonic acidemia (HP:0002912)1.61798534
152Abnormality of cochlea (HP:0000375)1.60768330
153Pancreatic fibrosis (HP:0100732)1.59628747
154Abnormality of the septum pellucidum (HP:0007375)1.58669414
155Small intestinal stenosis (HP:0012848)1.57664481
156Duodenal stenosis (HP:0100867)1.57664481
157Stenosis of the external auditory canal (HP:0000402)1.56962346
158Hypoglycemic coma (HP:0001325)1.56566498
159Esophageal atresia (HP:0002032)1.56441230
160Medulloblastoma (HP:0002885)1.56411306
161Spastic diplegia (HP:0001264)1.55049515
162True hermaphroditism (HP:0010459)1.54771778
163Bilateral microphthalmos (HP:0007633)1.53584901
164Abnormality of aspartate family amino acid metabolism (HP:0010899)1.50409025
165Morphological abnormality of the inner ear (HP:0011390)1.49490482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.81750106
2WEE14.74202541
3EIF2AK13.78371509
4VRK23.09180815
5BRSK23.02801041
6PLK42.93050843
7NME22.83797291
8STK162.81074376
9NEK22.79706894
10TSSK62.67680340
11SRPK12.42915898
12NEK12.40058693
13EIF2AK32.34793694
14AKT32.28960867
15ACVR1B2.16260416
16TTK2.16093991
17MKNK22.15859043
18PLK32.12899264
19PLK12.11795575
20BRSK11.96110149
21BCKDK1.92261291
22CDC71.85755871
23MKNK11.85733891
24DYRK31.77732690
25STK38L1.67948781
26MST41.56920068
27CCNB11.56344474
28PDK41.48849400
29PDK31.48849400
30LATS21.48254128
31TNIK1.46114688
32EPHA21.42385761
33AURKB1.41771918
34BCR1.40327687
35TRIM281.31188618
36ZAK1.30379070
37RPS6KA41.29437681
38CDK191.26635699
39CHEK21.26546905
40CASK1.23063930
41PINK11.22693855
42TESK21.21522615
43AURKA1.20558722
44BRAF1.18838499
45VRK11.18616828
46PDK21.16374626
47CDK71.15808115
48TAF11.13314729
49STK31.07385985
50CDK41.02746292
51MAP2K71.00581557
52ARAF1.00000666
53EIF2AK20.89616351
54MAP3K80.87829903
55CHEK10.86344879
56NME10.86045971
57STK390.84869570
58ATR0.83767417
59PLK20.81334944
60PIM20.80792894
61BMPR1B0.80635427
62WNK30.79329514
63CSNK1G30.75633011
64MAP3K40.74988498
65PNCK0.74526898
66IRAK30.74515218
67WNK40.73648930
68ALK0.71294744
69PRKCI0.69244656
70ERBB30.68122757
71EPHA40.66594463
72SCYL20.66324661
73FGFR10.65419026
74CSNK2A10.62766282
75CSNK2A20.62747853
76LATS10.61895870
77CDK20.61006325
78MINK10.60556178
79LIMK10.59339775
80CDK140.59247423
81CSNK1G10.59246892
82PAK10.58235078
83EPHB20.58208137
84ERBB40.57589133
85OBSCN0.55200635
86MELK0.53843162
87ABL20.52819619
88OXSR10.52372703
89TLK10.52367509
90CDK180.51837783
91CDK11A0.51534045
92NTRK20.50568922
93DYRK20.50249428
94NUAK10.49506122
95UHMK10.49443780
96CDK150.49392822
97CSNK1E0.49181097
98MAP4K20.49158335
99MAP3K30.48645501
100CDK10.46244482
101CDK30.45741653
102PIM10.45437707
103CSNK1A1L0.44692310
104CDK80.43380413
105STK240.43050275
106PRKD30.42507387
107CAMK2G0.40826557
108ATM0.40402029
109CSNK1G20.40332164
110MARK30.40234239
111PAK40.37686296
112PRKAA10.37624068
113STK40.36961014
114RPS6KA50.31041218
115AKT20.30927457
116CDK60.27392698
117RPS6KB20.27266082
118NEK60.26728597
119PRKCG0.26703615
120NEK90.26575980
121PASK0.25957217
122MAP3K50.25800314
123TAOK20.24973325
124CSNK1A10.23668831
125KDR0.23646696
126CAMKK20.22872412
127MAPK110.21442782
128MAP2K30.21293773
129MAP2K20.19387603
130STK100.18968017
131RAF10.18106282
132MTOR0.16699184
133PBK0.15933184

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.53131089
2RNA polymerase_Homo sapiens_hsa030204.33777864
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.99119714
4Proteasome_Homo sapiens_hsa030503.29161770
5RNA transport_Homo sapiens_hsa030132.88221787
6DNA replication_Homo sapiens_hsa030302.64654122
7Pyrimidine metabolism_Homo sapiens_hsa002402.52063176
8Folate biosynthesis_Homo sapiens_hsa007902.30011429
9Spliceosome_Homo sapiens_hsa030402.26873405
10Mismatch repair_Homo sapiens_hsa034302.16227460
11Ribosome_Homo sapiens_hsa030102.09858390
12* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08117652
13Cell cycle_Homo sapiens_hsa041102.01580938
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.98175818
15Basal transcription factors_Homo sapiens_hsa030221.89174113
16Nucleotide excision repair_Homo sapiens_hsa034201.82334583
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.79527983
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.77444167
19Homologous recombination_Homo sapiens_hsa034401.73970027
20One carbon pool by folate_Homo sapiens_hsa006701.72415163
21Alzheimers disease_Homo sapiens_hsa050101.70226489
22* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.68036632
23Regulation of autophagy_Homo sapiens_hsa041401.59510142
24Base excision repair_Homo sapiens_hsa034101.56626994
25Purine metabolism_Homo sapiens_hsa002301.52763299
26Biosynthesis of amino acids_Homo sapiens_hsa012301.52404565
27Vitamin digestion and absorption_Homo sapiens_hsa049771.51019892
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43286395
29Pentose phosphate pathway_Homo sapiens_hsa000301.40910976
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36850870
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32588819
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31661114
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30266919
34Cardiac muscle contraction_Homo sapiens_hsa042601.27163704
35Sulfur relay system_Homo sapiens_hsa041221.26931659
36Fanconi anemia pathway_Homo sapiens_hsa034601.23311042
37p53 signaling pathway_Homo sapiens_hsa041151.20898816
38Carbon metabolism_Homo sapiens_hsa012001.16524661
39Selenocompound metabolism_Homo sapiens_hsa004501.12077923
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.11043319
41RNA degradation_Homo sapiens_hsa030181.07939969
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05884137
43Butanoate metabolism_Homo sapiens_hsa006501.00075683
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99706232
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.97565853
46Glycerophospholipid metabolism_Homo sapiens_hsa005640.96420942
47mRNA surveillance pathway_Homo sapiens_hsa030150.93264823
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92756132
49Glutathione metabolism_Homo sapiens_hsa004800.89460476
50Arginine and proline metabolism_Homo sapiens_hsa003300.88045111
51Oocyte meiosis_Homo sapiens_hsa041140.84868141
52Epstein-Barr virus infection_Homo sapiens_hsa051690.81882688
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81555369
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.81242390
55beta-Alanine metabolism_Homo sapiens_hsa004100.81042561
56Propanoate metabolism_Homo sapiens_hsa006400.80708986
57Fatty acid degradation_Homo sapiens_hsa000710.79705166
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79575804
59Arginine biosynthesis_Homo sapiens_hsa002200.78727582
60Basal cell carcinoma_Homo sapiens_hsa052170.77843743
61Fructose and mannose metabolism_Homo sapiens_hsa000510.77397591
62Peroxisome_Homo sapiens_hsa041460.74153745
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74122803
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72995322
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72580562
66* Metabolic pathways_Homo sapiens_hsa011000.70116139
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69430623
68Nitrogen metabolism_Homo sapiens_hsa009100.67154483
69Fatty acid metabolism_Homo sapiens_hsa012120.64670533
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61968635
71Retinol metabolism_Homo sapiens_hsa008300.59885192
72Non-homologous end-joining_Homo sapiens_hsa034500.59453633
73Tryptophan metabolism_Homo sapiens_hsa003800.58363400
74Hedgehog signaling pathway_Homo sapiens_hsa043400.57764542
75Steroid biosynthesis_Homo sapiens_hsa001000.56578696
76Hippo signaling pathway_Homo sapiens_hsa043900.55396216
77Fatty acid elongation_Homo sapiens_hsa000620.53622278
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52706844
79Pyruvate metabolism_Homo sapiens_hsa006200.51206171
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50867691
81Huntingtons disease_Homo sapiens_hsa050160.50750579
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49068693
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47044424
84Protein export_Homo sapiens_hsa030600.45971196
85Chemical carcinogenesis_Homo sapiens_hsa052040.42653931
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.40934595
87PPAR signaling pathway_Homo sapiens_hsa033200.40497058
88Wnt signaling pathway_Homo sapiens_hsa043100.39995182
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39957779
90Glycerolipid metabolism_Homo sapiens_hsa005610.39616396
91Fat digestion and absorption_Homo sapiens_hsa049750.39377965
92Complement and coagulation cascades_Homo sapiens_hsa046100.35487552
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34115526
94Phenylalanine metabolism_Homo sapiens_hsa003600.33887874
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32337298
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31248616
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.30679771
98Tyrosine metabolism_Homo sapiens_hsa003500.30308459
99Nicotine addiction_Homo sapiens_hsa050330.29658476
100Parkinsons disease_Homo sapiens_hsa050120.29044718
101Oxidative phosphorylation_Homo sapiens_hsa001900.27804052
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27479145
103Galactose metabolism_Homo sapiens_hsa000520.27242427
104Lysine degradation_Homo sapiens_hsa003100.26930331
105Histidine metabolism_Homo sapiens_hsa003400.26091149
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25981385
107Linoleic acid metabolism_Homo sapiens_hsa005910.25786858
108TGF-beta signaling pathway_Homo sapiens_hsa043500.25733753
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24857934
110N-Glycan biosynthesis_Homo sapiens_hsa005100.24624766
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21767117
112Arachidonic acid metabolism_Homo sapiens_hsa005900.21555235
113Circadian rhythm_Homo sapiens_hsa047100.19261032
114Alcoholism_Homo sapiens_hsa050340.18422354
115Fatty acid biosynthesis_Homo sapiens_hsa000610.18178737
116Caffeine metabolism_Homo sapiens_hsa002320.15891623
117alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14739038
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.13154699
119Systemic lupus erythematosus_Homo sapiens_hsa053220.12512531

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