GCNT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)9.12758520
2bundle of His cell to Purkinje myocyte communication (GO:0086069)8.19551308
3* O-glycan processing (GO:0016266)7.05002003
4intestinal epithelial cell development (GO:0060576)7.04787123
5sulfation (GO:0051923)6.94117343
63-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.77292776
7purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.77292776
8digestion (GO:0007586)6.62256015
9regulation of guanylate cyclase activity (GO:0031282)5.84890109
10* digestive system process (GO:0022600)5.80134824
11* intestinal absorption (GO:0050892)5.34583062
12positive regulation of respiratory burst (GO:0060267)5.32569567
13flavonoid metabolic process (GO:0009812)5.29445680
14nucleotide-sugar biosynthetic process (GO:0009226)5.24118625
15hepatocyte apoptotic process (GO:0097284)5.23351737
16sulfate transmembrane transport (GO:1902358)5.08769392
17actin filament depolymerization (GO:0030042)5.06935696
18bile acid and bile salt transport (GO:0015721)4.91106717
19glandular epithelial cell differentiation (GO:0002067)4.87926926
20lung secretory cell differentiation (GO:0061140)4.68546082
21nucleotide-sugar metabolic process (GO:0009225)4.66472067
22* protein O-linked glycosylation (GO:0006493)4.62045603
23hemidesmosome assembly (GO:0031581)4.61277531
24positive regulation of guanylate cyclase activity (GO:0031284)4.60785016
25glutathione derivative biosynthetic process (GO:1901687)4.54838744
26glutathione derivative metabolic process (GO:1901685)4.54838744
27vitamin A metabolic process (GO:0006776)4.50252553
28sulfur amino acid catabolic process (GO:0000098)4.49440521
29intestinal cholesterol absorption (GO:0030299)4.27483484
30regulation of bile acid biosynthetic process (GO:0070857)4.23469635
31sulfate transport (GO:0008272)4.18324079
32hypotonic response (GO:0006971)4.17107096
33fucose catabolic process (GO:0019317)4.13157310
34L-fucose metabolic process (GO:0042354)4.13157310
35L-fucose catabolic process (GO:0042355)4.13157310
36thyroid hormone metabolic process (GO:0042403)4.08913760
37protein autoprocessing (GO:0016540)4.03020863
38regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.02025163
39positive regulation of fatty acid beta-oxidation (GO:0032000)4.01988723
40ventricular cardiac muscle cell action potential (GO:0086005)4.00575245
41auditory receptor cell differentiation (GO:0042491)3.96058168
42sperm capacitation (GO:0048240)3.93952407
43bicarbonate transport (GO:0015701)3.88771454
44cellular glucuronidation (GO:0052695)3.87979505
45desmosome organization (GO:0002934)3.86931592
46angiotensin maturation (GO:0002003)3.82557729
47arginine metabolic process (GO:0006525)3.80573472
48thrombin receptor signaling pathway (GO:0070493)3.80210491
49oligosaccharide biosynthetic process (GO:0009312)3.77899516
50phospholipid scrambling (GO:0017121)3.75959548
51fucosylation (GO:0036065)3.74357115
52glomerular filtration (GO:0003094)3.73548970
53positive regulation of fatty acid oxidation (GO:0046321)3.69744958
54transcytosis (GO:0045056)3.69674807
55regulation of proton transport (GO:0010155)3.65550642
56regulation of systemic arterial blood pressure by hormone (GO:0001990)3.64939548
57regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.64939548
58endocrine process (GO:0050886)3.64939548
59regulation of cGMP biosynthetic process (GO:0030826)3.60875137
60regulation of cellular extravasation (GO:0002691)3.60276169
61drug transmembrane transport (GO:0006855)3.54773566
62glucuronate metabolic process (GO:0019585)3.51372706
63uronic acid metabolic process (GO:0006063)3.51372706
64positive regulation of actin filament depolymerization (GO:0030836)3.51302541
65renal filtration (GO:0097205)3.45899611
66epoxygenase P450 pathway (GO:0019373)3.44693771
67regulation of respiratory burst (GO:0060263)3.41551946
68phosphatidylserine acyl-chain remodeling (GO:0036150)3.40164727
69alkaloid metabolic process (GO:0009820)3.40025487
70galactose catabolic process (GO:0019388)3.37973374
71regulation of pH (GO:0006885)3.37723587
72regulation of systemic arterial blood pressure (GO:0003073)3.37103235
73antibacterial humoral response (GO:0019731)3.36872344
74drug catabolic process (GO:0042737)3.29046983
75interferon-gamma secretion (GO:0072643)3.27729698
76cell communication involved in cardiac conduction (GO:0086065)3.26716983
77drug metabolic process (GO:0017144)3.26024678
78tight junction assembly (GO:0070830)3.25956448
79antimicrobial humoral response (GO:0019730)3.24951341
80calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.23786103
81behavioral response to nicotine (GO:0035095)3.22121910
82response to iron ion (GO:0010039)3.19757443
83cardiac conduction (GO:0061337)3.17751501
84cell differentiation involved in embryonic placenta development (GO:0060706)3.17674202
85epithelial cell-cell adhesion (GO:0090136)3.17289937
86phosphatidylinositol acyl-chain remodeling (GO:0036149)3.14069821
87pyrimidine-containing compound transmembrane transport (GO:0072531)3.14067307
88phenylpropanoid metabolic process (GO:0009698)3.12938482
89regulation of cGMP metabolic process (GO:0030823)3.12906824
90regulation of chemokine secretion (GO:0090196)3.12132744
91regulation of heart rate by cardiac conduction (GO:0086091)3.11905683
92regulation of vitamin metabolic process (GO:0030656)3.10046028
93sulfur compound transport (GO:0072348)3.10000744
94receptor guanylyl cyclase signaling pathway (GO:0007168)3.07585741
95ethanol oxidation (GO:0006069)3.05653905
96cellular ketone body metabolic process (GO:0046950)3.04961147
97exogenous drug catabolic process (GO:0042738)3.04225277
98arginine catabolic process (GO:0006527)3.03348871
99drug transport (GO:0015893)3.01492757
100negative regulation of digestive system process (GO:0060457)3.01071751
101extracellular fibril organization (GO:0043206)3.01062861
102regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.00175764
103GDP-mannose metabolic process (GO:0019673)2.98153441
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.97741711
105vitamin transmembrane transport (GO:0035461)2.97400449
106bile acid metabolic process (GO:0008206)2.95749183
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.94944489
108negative regulation of cell fate commitment (GO:0010454)2.94166566
109keratinocyte proliferation (GO:0043616)2.93502646
110transepithelial transport (GO:0070633)2.93112835
111positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.93067585
112fucose metabolic process (GO:0006004)2.91555683
113glutathione metabolic process (GO:0006749)2.90943032
114regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.89644826
115phosphatidylserine metabolic process (GO:0006658)2.88610755
116phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.88018418
117regulation of cholesterol homeostasis (GO:2000188)2.87045509
118positive regulation of pseudopodium assembly (GO:0031274)2.86853547
119amino sugar metabolic process (GO:0006040)2.86508894
120positive regulation of fatty acid transport (GO:2000193)2.85971794
121nucleotide transmembrane transport (GO:1901679)2.85841855
122positive regulation of epidermal cell differentiation (GO:0045606)2.84414457
123positive regulation of icosanoid secretion (GO:0032305)2.83741125
124ribonucleoside bisphosphate metabolic process (GO:0033875)2.80781360
125nucleoside bisphosphate metabolic process (GO:0033865)2.80781360
126purine nucleoside bisphosphate metabolic process (GO:0034032)2.80781360
127regulation of membrane lipid distribution (GO:0097035)2.79472031
128cellular response to hepatocyte growth factor stimulus (GO:0035729)2.78993446
129response to hepatocyte growth factor (GO:0035728)2.78993446
130negative regulation of keratinocyte proliferation (GO:0010839)2.78205577
131primary alcohol catabolic process (GO:0034310)2.77669802
132positive regulation of protein localization to plasma membrane (GO:1903078)2.77405194
133regulation of actin nucleation (GO:0051125)2.77060009
134positive regulation of glycoprotein biosynthetic process (GO:0010560)2.76449750
135glycerol metabolic process (GO:0006071)2.76109013
136xenobiotic metabolic process (GO:0006805)2.75976477
137renal system process involved in regulation of blood volume (GO:0001977)2.75723385
138negative regulation of hormone metabolic process (GO:0032351)2.74619780
139diol metabolic process (GO:0034311)2.74192623
140fibril organization (GO:0097435)2.73361388
141positive regulation of cGMP biosynthetic process (GO:0030828)2.72587860
142cellular response to pH (GO:0071467)2.71962588
143virion attachment to host cell (GO:0019062)2.70065871
144adhesion of symbiont to host cell (GO:0044650)2.70065871
145peptide hormone processing (GO:0016486)2.69254079
146phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.69225395
147cobalamin metabolic process (GO:0009235)2.68488484
148membrane repolarization during action potential (GO:0086011)2.68091481
149water-soluble vitamin biosynthetic process (GO:0042364)2.68064930
150striated muscle atrophy (GO:0014891)2.67954943
151regulation of triglyceride catabolic process (GO:0010896)2.67447478
152embryonic foregut morphogenesis (GO:0048617)2.67150205
153ketone body metabolic process (GO:1902224)2.67089248
154columnar/cuboidal epithelial cell development (GO:0002066)2.65831921
155vitamin biosynthetic process (GO:0009110)2.65773801
156signal transduction involved in regulation of gene expression (GO:0023019)2.65617076
157excretion (GO:0007588)2.65605001
158primary alcohol metabolic process (GO:0034308)2.65146789
159fat-soluble vitamin biosynthetic process (GO:0042362)2.63482671
160indolalkylamine metabolic process (GO:0006586)2.62735956
161positive regulation of prostaglandin secretion (GO:0032308)2.61796619
162glycine transport (GO:0015816)2.61557403
163negative regulation of leukocyte chemotaxis (GO:0002689)2.55610331
164endocrine pancreas development (GO:0031018)2.54915991
165maintenance of gastrointestinal epithelium (GO:0030277)13.3443894
166epithelial structure maintenance (GO:0010669)10.0646605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.53628173
2* SOX2_27498859_Chip-Seq_STOMACH_Mouse5.26675873
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.91015378
4GATA4_25053715_ChIP-Seq_YYC3_Human3.65118195
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.62792261
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.46579534
7CDX2_19796622_ChIP-Seq_MESCs_Mouse3.13615330
8* SOX2_20726797_ChIP-Seq_SW620_Human3.09725237
9GATA6_25053715_ChIP-Seq_YYC3_Human3.03431669
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98550539
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90346273
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.85632457
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79677463
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.64249873
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.63798765
16PPAR_26484153_Chip-Seq_NCI-H1993_Human2.62115778
17ESR1_20079471_ChIP-ChIP_T-47D_Human2.45590728
18ZNF274_21170338_ChIP-Seq_K562_Hela2.40773608
19TRIM28_21343339_ChIP-Seq_HEK293_Human2.39606271
20* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.37155753
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.25668013
22EZH2_22144423_ChIP-Seq_EOC_Human2.20365385
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.13110221
24KLF5_25053715_ChIP-Seq_YYC3_Human2.07335520
25FOXO3_23340844_ChIP-Seq_DLD1_Human2.02898212
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01534013
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.99396912
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.99396912
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.92044937
30RUNX1_27514584_Chip-Seq_MCF-7_Human1.89818440
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.89436853
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.85870476
33FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.84524986
34IRF8_22096565_ChIP-ChIP_GC-B_Human1.79035414
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78061100
36HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74434189
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73837661
38AR_21909140_ChIP-Seq_LNCAP_Human1.66775670
39SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64756752
40VDR_22108803_ChIP-Seq_LS180_Human1.63726182
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61984203
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56001815
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55697928
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55302755
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55252775
46AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54203382
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53908757
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52855071
49* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51819039
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.48864965
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42736560
52GATA3_24758297_ChIP-Seq_MCF-7_Human1.42338887
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41961901
54JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41329734
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.37134393
56GBX2_23144817_ChIP-Seq_PC3_Human1.36423982
57FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34542606
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33399200
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33222081
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.32948938
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32948938
62TCF4_22108803_ChIP-Seq_LS180_Human1.31042310
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30965419
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.30879771
65NANOG_20526341_ChIP-Seq_ESCs_Human1.30463874
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.29785631
67* LXR_22158963_ChIP-Seq_LIVER_Mouse1.29728234
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28766591
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.27825237
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.26932609
71DROSHA_22980978_ChIP-Seq_HELA_Human1.26235265
72RACK7_27058665_Chip-Seq_MCF-7_Human1.24798479
73ER_23166858_ChIP-Seq_MCF-7_Human1.24444448
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23528785
75CJUN_26792858_Chip-Seq_BT549_Human1.23307125
76* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23091240
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22962094
78AR_20517297_ChIP-Seq_VCAP_Human1.22634652
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21676679
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21599973
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21490636
82AHR_22903824_ChIP-Seq_MCF-7_Human1.20699962
83CEBPB_22108803_ChIP-Seq_LS180_Human1.19938465
84ATF3_27146783_Chip-Seq_COLON_Human1.19729112
85AR_25329375_ChIP-Seq_VCAP_Human1.19555157
86CDX2_22108803_ChIP-Seq_LS180_Human1.19373465
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17930358
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17305170
89SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16794750
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.16455503
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16068560
92GATA3_21878914_ChIP-Seq_MCF-7_Human1.15433237
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14710238
94RXR_22158963_ChIP-Seq_LIVER_Mouse1.13217401
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13140302
96NCOR_22424771_ChIP-Seq_293T_Human1.12852850
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11717126
98BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11469323
99BCAT_22108803_ChIP-Seq_LS180_Human1.10928014
100ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10436904
101SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09875846
102PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08332234
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08283702
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.07438698
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07329941
106CBP_20019798_ChIP-Seq_JUKART_Human1.07329941
107* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06809320
108TP53_16413492_ChIP-PET_HCT116_Human1.05481699
109ZNF263_19887448_ChIP-Seq_K562_Human1.05282619
110AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03905178
111EGR1_19032775_ChIP-ChIP_M12_Human1.03628164
112P53_21459846_ChIP-Seq_SAOS-2_Human1.02416203
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.01620756
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01611496
115P300_19829295_ChIP-Seq_ESCs_Human1.01496896
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00537104
117GATA2_21666600_ChIP-Seq_HMVEC_Human1.00379862
118HOXB7_26014856_ChIP-Seq_BT474_Human0.99789591
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99721093
120FOXH1_21741376_ChIP-Seq_ESCs_Human0.99344855
121STAT3_23295773_ChIP-Seq_U87_Human0.98528297
122GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98485426
123SOX2_19829295_ChIP-Seq_ESCs_Human0.97615718
124NANOG_19829295_ChIP-Seq_ESCs_Human0.97615718
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97270835
126FOXA2_19822575_ChIP-Seq_HepG2_Human0.96913314
127TAF2_19829295_ChIP-Seq_ESCs_Human0.96855178
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96322950
129ERA_21632823_ChIP-Seq_H3396_Human0.95608154
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95346390
131HNF4A_19822575_ChIP-Seq_HepG2_Human0.94830952
132* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94268175
133TCF4_23295773_ChIP-Seq_U87_Human0.94065553
134MYC_19829295_ChIP-Seq_ESCs_Human0.93655488
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92598429
136GATA2_19941826_ChIP-Seq_K562_Human0.92305191
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92278859
138KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91333556
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.87472818
140EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.87217018
141PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86674779
142RXR_22108803_ChIP-Seq_LS180_Human0.84594433
143ELF5_23300383_ChIP-Seq_T47D_Human0.82407383
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.79889558
145CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79848541
146CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79216750
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77218813
148CLOCK_20551151_ChIP-Seq_293T_Human0.75720889
149* TP63_23658742_ChIP-Seq_EP156T_Human0.75074048
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74585350
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.72753335
152VDR_24787735_ChIP-Seq_THP-1_Human0.71503885
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.69995758
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.69166375
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.69166375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH9.75327299
2MP0001873_stomach_inflammation5.39359414
3MP0010234_abnormal_vibrissa_follicle4.99522490
4MP0001666_abnormal_nutrient_absorption3.96467591
5* MP0001664_abnormal_digestion3.85754809
6MP0004264_abnormal_extraembryonic_tissu3.78056679
7MP0001663_abnormal_digestive_system3.30250409
8MP0003866_abnormal_defecation3.28341119
9MP0000462_abnormal_digestive_system3.25544789
10MP0005381_digestive/alimentary_phenotyp3.06180414
11MP0000470_abnormal_stomach_morphology2.96784482
12MP0005085_abnormal_gallbladder_physiolo2.85874798
13MP0006054_spinal_hemorrhage2.78484167
14MP0000537_abnormal_urethra_morphology2.62244694
15MP0002876_abnormal_thyroid_physiology2.58983487
16MP0000490_abnormal_crypts_of2.47067445
17* MP0010155_abnormal_intestine_physiology2.37720611
18MP0005360_urolithiasis2.21465532
19* MP0000477_abnormal_intestine_morphology2.21268350
20MP0005365_abnormal_bile_salt2.08765733
21MP0010352_gastrointestinal_tract_polyps2.01259834
22MP0002822_catalepsy2.00972776
23MP0003868_abnormal_feces_composition1.95674295
24MP0003252_abnormal_bile_duct1.78714775
25MP0003195_calcinosis1.77412204
26MP0003806_abnormal_nucleotide_metabolis1.76651821
27MP0005332_abnormal_amino_acid1.70782638
28MP0001485_abnormal_pinna_reflex1.68167743
29MP0001501_abnormal_sleep_pattern1.61518751
30MP0003300_gastrointestinal_ulcer1.59794262
31MP0003878_abnormal_ear_physiology1.59540778
32MP0005377_hearing/vestibular/ear_phenot1.59540778
33MP0005167_abnormal_blood-brain_barrier1.58594198
34MP0008875_abnormal_xenobiotic_pharmacok1.55948631
35MP0003705_abnormal_hypodermis_morpholog1.52028349
36MP0003283_abnormal_digestive_organ1.49440537
37MP0004782_abnormal_surfactant_physiolog1.43347006
38MP0003879_abnormal_hair_cell1.40851403
39MP0009840_abnormal_foam_cell1.40131145
40MP0003718_maternal_effect1.40011611
41MP0009384_cardiac_valve_regurgitation1.38367183
42MP0010678_abnormal_skin_adnexa1.37855841
43MP0001756_abnormal_urination1.37707274
44MP0000230_abnormal_systemic_arterial1.33567850
45MP0002796_impaired_skin_barrier1.33102809
46MP0001849_ear_inflammation1.32599824
47MP0002009_preneoplasia1.32365669
48MP0000538_abnormal_urinary_bladder1.30475059
49MP0002277_abnormal_respiratory_mucosa1.21154286
50MP0000465_gastrointestinal_hemorrhage1.10964188
51MP0000467_abnormal_esophagus_morphology1.10801552
52MP0001764_abnormal_homeostasis1.09036306
53MP0004043_abnormal_pH_regulation1.08829495
54MP0005670_abnormal_white_adipose1.05374877
55MP0005165_increased_susceptibility_to1.05269395
56MP0005448_abnormal_energy_balance1.03328149
57MP0002139_abnormal_hepatobiliary_system1.01186512
58MP0002254_reproductive_system_inflammat1.00877663
59MP0008775_abnormal_heart_ventricle0.99833785
60MP0009379_abnormal_foot_pigmentation0.99719378
61MP0003453_abnormal_keratinocyte_physiol0.99606553
62MP0003724_increased_susceptibility_to0.99270645
63MP0000427_abnormal_hair_cycle0.98962911
64MP0004885_abnormal_endolymph0.98837077
65MP0005501_abnormal_skin_physiology0.97759914
66MP0005645_abnormal_hypothalamus_physiol0.97593795
67MP0001986_abnormal_taste_sensitivity0.97559985
68MP0005636_abnormal_mineral_homeostasis0.97347559
69MP0003646_muscle_fatigue0.96867415
70MP0002733_abnormal_thermal_nociception0.94563851
71MP0003941_abnormal_skin_development0.93461644
72MP0005551_abnormal_eye_electrophysiolog0.93224976
73MP0001765_abnormal_ion_homeostasis0.89744287
74MP0004215_abnormal_myocardial_fiber0.88431249
75MP0004147_increased_porphyrin_level0.87339672
76MP0004947_skin_inflammation0.84832462
77MP0003953_abnormal_hormone_level0.84525734
78MP0002060_abnormal_skin_morphology0.84443418
79MP0004019_abnormal_vitamin_homeostasis0.84238794
80MP0001216_abnormal_epidermal_layer0.83701108
81MP0010329_abnormal_lipoprotein_level0.83093863
82MP0000678_abnormal_parathyroid_gland0.82261051
83MP0005319_abnormal_enzyme/_coenzyme0.81861208
84MP0005174_abnormal_tail_pigmentation0.80085686
85MP0002837_dystrophic_cardiac_calcinosis0.78974725
86MP0002098_abnormal_vibrissa_morphology0.78922902
87MP0001970_abnormal_pain_threshold0.77133549
88MP0000566_synostosis0.76532661
89MP0003119_abnormal_digestive_system0.74843745
90MP0005310_abnormal_salivary_gland0.74389221
91MP0005166_decreased_susceptibility_to0.74209934
92MP0000516_abnormal_urinary_system0.73545647
93MP0005367_renal/urinary_system_phenotyp0.73545647
94MP0002102_abnormal_ear_morphology0.71905772
95MP0003638_abnormal_response/metabolism_0.69059657
96MP0003136_yellow_coat_color0.68491926
97MP0002909_abnormal_adrenal_gland0.68271618
98MP0009643_abnormal_urine_homeostasis0.67993458
99MP0005084_abnormal_gallbladder_morpholo0.64970961
100MP0002163_abnormal_gland_morphology0.64547801
101MP0000026_abnormal_inner_ear0.62329477
102MP0009780_abnormal_chondrocyte_physiolo0.61828780
103MP0009642_abnormal_blood_homeostasis0.61502785
104MP0005389_reproductive_system_phenotype0.61375575
105MP0002078_abnormal_glucose_homeostasis0.60416431
106MP0003183_abnormal_peptide_metabolism0.58712965
107MP0002693_abnormal_pancreas_physiology0.57618540
108MP0000613_abnormal_salivary_gland0.57547862
109MP0005248_abnormal_Harderian_gland0.55957066
110MP0005646_abnormal_pituitary_gland0.55522360
111MP0003045_fibrosis0.55520396
112MP0004484_altered_response_of0.55440246
113MP0005083_abnormal_biliary_tract0.55241069
114MP0005408_hypopigmentation0.55045189
115MP0000631_abnormal_neuroendocrine_gland0.54968653
116MP0009785_altered_susceptibility_to0.54776524
117MP0010771_integument_phenotype0.54446198
118MP0002166_altered_tumor_susceptibility0.52460843
119MP0003566_abnormal_cell_adhesion0.52434796
120MP0001919_abnormal_reproductive_system0.52243689
121MP0002272_abnormal_nervous_system0.51723044
122MP0002006_tumorigenesis0.51151146
123MP0002160_abnormal_reproductive_system0.50914157
124MP0005266_abnormal_metabolism0.50716545
125MP0001502_abnormal_circadian_rhythm0.50666399
126MP0008873_increased_physiological_sensi0.50601946
127MP0005395_other_phenotype0.50267589
128MP0000627_abnormal_mammary_gland0.49677018
129MP0003315_abnormal_perineum_morphology0.49282750
130MP0003191_abnormal_cellular_cholesterol0.47437844
131MP0004185_abnormal_adipocyte_glucose0.45642250
132MP0008872_abnormal_physiological_respon0.44482404
133MP0002138_abnormal_hepatobiliary_system0.43607100
134* MP0001845_abnormal_inflammatory_respons0.43271105
135MP0002234_abnormal_pharynx_morphology0.42321927
136MP0000609_abnormal_liver_physiology0.41580885
137MP0009053_abnormal_anal_canal0.41331602
138MP0000383_abnormal_hair_follicle0.41282764
139MP0001191_abnormal_skin_condition0.40761129
140MP0002136_abnormal_kidney_physiology0.40129834
141MP0000377_abnormal_hair_follicle0.39848803
142MP0003693_abnormal_embryo_hatching0.39370369
143MP0005410_abnormal_fertilization0.39365545
144MP0003936_abnormal_reproductive_system0.38400538
145MP0010386_abnormal_urinary_bladder0.35476069
146MP0002877_abnormal_melanocyte_morpholog0.35069282
147MP0001188_hyperpigmentation0.34337099
148MP0002118_abnormal_lipid_homeostasis0.34047830

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)8.80114314
2Ileus (HP:0002595)7.87406459
3Chronic diarrhea (HP:0002028)4.90042679
4Conjugated hyperbilirubinemia (HP:0002908)4.59344726
5Flat acetabular roof (HP:0003180)4.46274403
6Abdominal distention (HP:0003270)4.45185234
7Hyperactive renin-angiotensin system (HP:0000841)4.25818710
8Alkalosis (HP:0001948)4.15381767
9Micronodular cirrhosis (HP:0001413)3.91188574
10Woolly hair (HP:0002224)3.89220903
11Malnutrition (HP:0004395)3.85452100
12Hyperaldosteronism (HP:0000859)3.83018819
13Onycholysis (HP:0001806)3.78871396
14Abnormal biliary tract morphology (HP:0012440)3.76577893
15Rectal prolapse (HP:0002035)3.74956755
16Milia (HP:0001056)3.72219193
17Metabolic alkalosis (HP:0200114)3.71254568
18Abnormality of chloride homeostasis (HP:0011422)3.59862784
19Abnormality of the gastric mucosa (HP:0004295)3.55743691
20Fat malabsorption (HP:0002630)3.49865405
21Palpitations (HP:0001962)3.49576441
22Abnormality of the distal phalanx of the thumb (HP:0009617)3.45760866
23Gastrointestinal dysmotility (HP:0002579)3.34891477
24Syncope (HP:0001279)3.31652118
25Pigmentary retinal degeneration (HP:0001146)3.30785899
26Curly hair (HP:0002212)3.29052776
27Atrophic scars (HP:0001075)3.24832398
28Cone-rod dystrophy (HP:0000548)3.18723135
29Abnormality of the vitamin B12 metabolism (HP:0004341)3.14137434
30Pustule (HP:0200039)3.13067382
31Mildly elevated creatine phosphokinase (HP:0008180)3.12307688
32Fragile nails (HP:0001808)3.06578463
33Intrahepatic cholestasis (HP:0001406)3.05162929
34Biliary tract neoplasm (HP:0100574)3.03365096
35Ventricular fibrillation (HP:0001663)2.99227788
36Plantar hyperkeratosis (HP:0007556)2.95343926
37Abnormality of the 1st metacarpal (HP:0010009)2.92986981
38Glycosuria (HP:0003076)2.92686772
39Abnormality of urine glucose concentration (HP:0011016)2.92686772
40Pili torti (HP:0003777)2.90097535
41Microretrognathia (HP:0000308)2.87431106
42Confusion (HP:0001289)2.86029142
43Hypokalemia (HP:0002900)2.85737836
44Abnormality of vitamin B metabolism (HP:0004340)2.85560968
45Abnormality of potassium homeostasis (HP:0011042)2.84937235
46Abnormal number of erythroid precursors (HP:0012131)2.78198046
47Aortic aneurysm (HP:0004942)2.77670324
48Flattened epiphyses (HP:0003071)2.74841811
49Villous atrophy (HP:0011473)2.72056637
50Abnormality of small intestinal villus morphology (HP:0011472)2.72056637
51Congenital sensorineural hearing impairment (HP:0008527)2.70969711
52Focal segmental glomerulosclerosis (HP:0000097)2.68750278
53Dehydration (HP:0001944)2.68489584
54Hyponatremia (HP:0002902)2.68453216
55Abnormality of the renal cortex (HP:0011035)2.68433067
56Tubular atrophy (HP:0000092)2.65122789
57Abnormality of cells of the erythroid lineage (HP:0012130)2.59761919
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.55933399
59Congenital stationary night blindness (HP:0007642)2.52029515
60Hyperkalemia (HP:0002153)2.51916494
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49227251
62Decreased circulating renin level (HP:0003351)2.48954767
63Progressive sensorineural hearing impairment (HP:0000408)2.48066463
64Abnormality of renin-angiotensin system (HP:0000847)2.47005044
65Cupped ribs (HP:0000887)2.46697197
66Congenital, generalized hypertrichosis (HP:0004540)2.44318117
67Abnormal tarsal ossification (HP:0008369)2.43462866
68Abnormal cartilage morphology (HP:0002763)2.42774594
69Abnormality of vitamin metabolism (HP:0100508)2.41983379
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.41958617
71Proximal tubulopathy (HP:0000114)2.41918321
72Ventricular tachycardia (HP:0004756)2.40520896
73Pendular nystagmus (HP:0012043)2.39375817
74Hypoalbuminemia (HP:0003073)2.36562595
75Abnormal albumin level (HP:0012116)2.36562595
76Renal cortical cysts (HP:0000803)2.36165058
77Hypoplasia of dental enamel (HP:0006297)2.33749681
78Hyperglycinuria (HP:0003108)2.32410383
79Acanthocytosis (HP:0001927)2.31972287
80Subacute progressive viral hepatitis (HP:0006572)2.30948951
81Fragile skin (HP:0001030)2.30253326
82Hyperparathyroidism (HP:0000843)2.29197324
83Glomerulosclerosis (HP:0000096)2.27322133
84Bundle branch block (HP:0011710)2.27293315
85Abnormal foot bone ossification (HP:0010675)2.26961718
86Abnormality of magnesium homeostasis (HP:0004921)2.26509664
87Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25674741
88Dicarboxylic aciduria (HP:0003215)2.25674741
89Spinal cord compression (HP:0002176)2.23469221
90Uterine neoplasm (HP:0010784)2.22676672
91Cerebral palsy (HP:0100021)2.22614438
92Aortic dissection (HP:0002647)2.22239611
93Neonatal short-limb short stature (HP:0008921)2.21362492
94Vertebral clefting (HP:0008428)2.20845731
95Abnormality of glycine metabolism (HP:0010895)2.20791563
96Abnormality of serine family amino acid metabolism (HP:0010894)2.20791563
97Late onset (HP:0003584)2.19746712
98Vertebral hypoplasia (HP:0008417)2.19392860
99Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19392860
100Hoarse voice (HP:0001609)2.18965853
101Ureteral stenosis (HP:0000071)2.16768138
102Goiter (HP:0000853)2.15692829
103Abnormal vertebral ossification (HP:0100569)2.15126540
104Abnormality of carpal bone ossification (HP:0006257)2.08744570
105Ventricular arrhythmia (HP:0004308)2.08617757
106Vascular calcification (HP:0004934)2.07754841
107Petechiae (HP:0000967)2.07561679
108Breast carcinoma (HP:0003002)2.07331145
109Neoplasm of the rectum (HP:0100743)2.04793525
110Male infertility (HP:0003251)2.04666929
111Metabolic acidosis (HP:0001942)2.01258474
112Amelogenesis imperfecta (HP:0000705)2.01247517
113Esophageal varix (HP:0002040)2.00741828
114Progressive hearing impairment (HP:0001730)2.00582067
115Short phalanx of the thumb (HP:0009660)1.99596021
116Ankyloglossia (HP:0010296)1.99575535
117Widely patent fontanelles and sutures (HP:0004492)1.98641550
118Pancreatic cysts (HP:0001737)1.98600375
119Methylmalonic aciduria (HP:0012120)1.97934367
120Abnormality of proline metabolism (HP:0010907)1.96975313
121Hydroxyprolinuria (HP:0003080)1.96975313
122Ureteral obstruction (HP:0006000)1.96333050
123Hyperammonemia (HP:0001987)1.95275574
124Abnormality of sodium homeostasis (HP:0010931)1.94130209
125Abnormality of renal excretion (HP:0011036)1.94121234
126Neoplasm of the small intestine (HP:0100833)1.90939942
127Abnormal hair laboratory examination (HP:0003328)1.90590500
128Deviation of the thumb (HP:0009603)1.90220764
129Autoimmune thrombocytopenia (HP:0001973)1.90150156
130Abolished electroretinogram (ERG) (HP:0000550)1.88441047
131Stomach cancer (HP:0012126)1.88264785
132Periodontitis (HP:0000704)1.88006447
133Germ cell neoplasia (HP:0100728)1.87663155
134Abnormality of the nasal septum (HP:0000419)1.85948273
135Increased circulating renin level (HP:0000848)1.85345047
136Renal salt wasting (HP:0000127)1.84997671
137Hypobetalipoproteinemia (HP:0003563)1.84281880
138Attenuation of retinal blood vessels (HP:0007843)1.83430336
139Hemorrhage of the eye (HP:0011885)1.83428939
140Short 1st metacarpal (HP:0010034)1.83254113
141Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83254113
142Cardiovascular calcification (HP:0011915)1.82200381
143Facial shape deformation (HP:0011334)1.81803601
144Potter facies (HP:0002009)1.81803601
145Abnormal pancreas size (HP:0012094)1.81399760
146Hypoplasia of the uterus (HP:0000013)1.80556080
147True hermaphroditism (HP:0010459)1.80550501
148Chorioretinal atrophy (HP:0000533)1.80244485
149Hypomagnesemia (HP:0002917)1.80102976
150Exocrine pancreatic insufficiency (HP:0001738)1.79796579
151Hyperphosphatemia (HP:0002905)1.78818546
152Renal tubular acidosis (HP:0001947)1.75225799
153Hyperventilation (HP:0002883)1.74534017
154Large for gestational age (HP:0001520)1.73611806
155Decreased central vision (HP:0007663)1.73419835
156Molar tooth sign on MRI (HP:0002419)1.72568653
157Abnormality of midbrain morphology (HP:0002418)1.72568653
158Lethargy (HP:0001254)1.72542519
159Tongue fasciculations (HP:0001308)1.72490823
160Adrenal overactivity (HP:0002717)1.70021160
161Abnormality of the renal medulla (HP:0100957)1.69935177
162Steatorrhea (HP:0002570)1.69176885
163Nephrolithiasis (HP:0000787)1.69092867
164Generalized aminoaciduria (HP:0002909)1.67670391
165Pancreatitis (HP:0001733)1.66365935
166Aplasia/hypoplasia of the uterus (HP:0008684)1.65471991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.19827741
2MST45.86553296
3ACVR1B5.45879790
4LMTK25.23470356
5ERBB45.08935582
6MST1R4.37361039
7TESK12.91318812
8PRKG22.77526342
9EPHA22.73496877
10MYLK2.68041567
11BMPR1B2.34439141
12MAP2K22.32723644
13ADRBK22.31671729
14TAOK32.31356435
15NUAK12.26882139
16PIK3CA1.88490911
17PTK61.86829291
18EPHB21.77183859
19ERN11.70203032
20MAP3K21.69795433
21MET1.68128340
22TNIK1.67356068
23NME11.60541229
24RIPK11.57018115
25FER1.47622955
26LATS11.46582918
27PDK31.45774900
28PDK41.45774900
29CASK1.36891281
30IRAK11.31129123
31PAK41.28048206
32TLK11.24548827
33STK241.23793629
34PDK21.21581763
35PINK11.20363580
36DAPK21.19759029
37MAP2K11.18762129
38EPHA31.17664621
39PRKCI1.15780478
40PHKG11.12638412
41PHKG21.12638412
42LIMK11.10858901
43STK101.08905636
44INSRR1.07719874
45ERBB20.96068955
46STK390.95327917
47NLK0.95109907
48ZAK0.94135093
49DMPK0.91104957
50RIPK40.91050847
51PTK20.90463459
52LRRK20.89714660
53MAP4K20.87833432
54STK38L0.84173457
55DDR20.83026285
56MAP3K120.82500889
57MAP3K100.80548608
58TXK0.79864914
59ADRBK10.78530480
60KSR20.78211548
61GRK60.77213728
62STK30.74163307
63PKN20.73645723
64WNK30.73076012
65PRKCE0.71510465
66RPS6KB20.67164975
67MAPKAPK30.66861467
68MAP3K80.66658205
69MAP3K40.65414689
70MAP3K70.64471123
71TTN0.58922857
72GRK10.56987469
73PIK3CG0.55987688
74MAP2K60.55555040
75PAK30.54103611
76TGFBR10.52569009
77ICK0.51194820
78MATK0.50993076
79ROCK10.49903974
80EEF2K0.49901427
81CDK60.49900376
82PBK0.49525126
83CDK80.49403357
84PRKAA20.48636259
85AURKB0.48542616
86MAP3K90.48390510
87PAK20.47438601
88BCR0.47218698
89DYRK1B0.47165839
90WNK40.46453769
91PDGFRB0.45097646
92YES10.42181534
93PRKCZ0.41947439
94IKBKB0.41252173
95CAMK2D0.40732174
96PAK10.38745386
97PIM20.38421128
98MAPK150.37640467
99FYN0.36900387
100SRC0.36446182
101FLT30.35561566
102NEK10.35383739
103PRKAA10.34681698
104IGF1R0.34482544
105TTK0.34441810
106MAP3K140.34415310
107CAMK2A0.33992017
108MELK0.33773598
109CSK0.33685838
110CAMK2G0.33034427
111ABL20.32507528
112BMPR20.32124684
113PRKACG0.31328394
114CAMK2B0.31274408
115PDPK10.30674706
116IRAK40.30101554
117IRAK30.29493163
118GRK50.28821261
119EPHB10.28470750
120MUSK0.27569933
121PRKACA0.27351966
122OXSR10.27055231
123TAOK10.26156507
124SIK10.26125639
125ROCK20.25555966
126KIT0.25114965
127MAP4K10.25110386
128EPHA40.25018874
129PDK10.24345800
130CSNK1A10.24241774
131IKBKE0.23659474
132SCYL20.22937516
133AKT30.22617709
134AKT20.22349773
135FGFR30.21973777
136BMX0.21879903
137TIE10.21773235
138MAP3K10.21451339
139NEK90.21213443
140MAPKAPK20.20681390
141WNK10.20408354
142PDGFRA0.20033564
143MAPK130.19895909
144CDK90.19483518
145CHUK0.18455251
146PRKCA0.17476996
147PRKCQ0.15622359
148MAPK110.15370591
149ITK0.15295288
150CDC42BPA0.14255295
151GSK3A0.12631339
152MAP3K30.12412580

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009206.43002817
2Mineral absorption_Homo sapiens_hsa049784.34345418
3Fat digestion and absorption_Homo sapiens_hsa049753.56212525
4* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.48147477
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.43381932
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.73982567
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.57316207
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.53118919
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.44698836
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.24166791
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24042556
12Glutathione metabolism_Homo sapiens_hsa004802.23358251
13Bile secretion_Homo sapiens_hsa049762.19847838
14Gastric acid secretion_Homo sapiens_hsa049712.19574771
15Vitamin digestion and absorption_Homo sapiens_hsa049771.98989411
16Renin-angiotensin system_Homo sapiens_hsa046141.89124977
17Chemical carcinogenesis_Homo sapiens_hsa052041.82786712
18Histidine metabolism_Homo sapiens_hsa003401.80169123
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.78099204
20Arginine biosynthesis_Homo sapiens_hsa002201.71629800
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70127719
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68428379
23Fructose and mannose metabolism_Homo sapiens_hsa000511.67689522
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.64704665
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.63599496
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62617439
27Galactose metabolism_Homo sapiens_hsa000521.56345810
28Starch and sucrose metabolism_Homo sapiens_hsa005001.54288562
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.53245945
30Pancreatic secretion_Homo sapiens_hsa049721.47745725
31Tight junction_Homo sapiens_hsa045301.44363387
32Linoleic acid metabolism_Homo sapiens_hsa005911.37050038
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26354407
34Fatty acid degradation_Homo sapiens_hsa000711.23119944
35Protein digestion and absorption_Homo sapiens_hsa049741.22395334
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.21887938
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06160578
38Glycerolipid metabolism_Homo sapiens_hsa005611.04383914
39Adherens junction_Homo sapiens_hsa045200.99179000
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98881164
41Thyroid cancer_Homo sapiens_hsa052160.97759577
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92242640
43Retinol metabolism_Homo sapiens_hsa008300.91242599
44Ether lipid metabolism_Homo sapiens_hsa005650.89886778
45Asthma_Homo sapiens_hsa053100.87646777
46Peroxisome_Homo sapiens_hsa041460.86856284
47Thyroid hormone synthesis_Homo sapiens_hsa049180.86771960
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85041534
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.84569113
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84544389
51Pentose phosphate pathway_Homo sapiens_hsa000300.83112587
52PPAR signaling pathway_Homo sapiens_hsa033200.82157384
53Fatty acid biosynthesis_Homo sapiens_hsa000610.80986848
54Salmonella infection_Homo sapiens_hsa051320.80866457
55Sphingolipid metabolism_Homo sapiens_hsa006000.80446119
56Caffeine metabolism_Homo sapiens_hsa002320.77749086
57Pyruvate metabolism_Homo sapiens_hsa006200.77357822
58Vibrio cholerae infection_Homo sapiens_hsa051100.73187800
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.72818180
60Folate biosynthesis_Homo sapiens_hsa007900.72533694
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69831302
62Arachidonic acid metabolism_Homo sapiens_hsa005900.68989378
63Phototransduction_Homo sapiens_hsa047440.67382799
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66894305
65Insulin secretion_Homo sapiens_hsa049110.65621312
66Ovarian steroidogenesis_Homo sapiens_hsa049130.64069270
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.63956421
68Tryptophan metabolism_Homo sapiens_hsa003800.62415579
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61808987
70Carbon metabolism_Homo sapiens_hsa012000.61004920
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60957251
72Taste transduction_Homo sapiens_hsa047420.60571139
73Bladder cancer_Homo sapiens_hsa052190.59211181
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.56636878
75Collecting duct acid secretion_Homo sapiens_hsa049660.51671936
76N-Glycan biosynthesis_Homo sapiens_hsa005100.51150079
77Butanoate metabolism_Homo sapiens_hsa006500.51141316
78ABC transporters_Homo sapiens_hsa020100.49760605
79Type I diabetes mellitus_Homo sapiens_hsa049400.49374435
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44766060
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43742993
82Phenylalanine metabolism_Homo sapiens_hsa003600.43489010
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42671366
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42231421
85Renin secretion_Homo sapiens_hsa049240.41740357
86Tyrosine metabolism_Homo sapiens_hsa003500.41612280
87Salivary secretion_Homo sapiens_hsa049700.41481877
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41008002
89Allograft rejection_Homo sapiens_hsa053300.39357587
90Serotonergic synapse_Homo sapiens_hsa047260.39205642
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.38676380
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37379934
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37045156
94Hepatitis C_Homo sapiens_hsa051600.36881058
95Graft-versus-host disease_Homo sapiens_hsa053320.36193588
96Autoimmune thyroid disease_Homo sapiens_hsa053200.35104756
97Small cell lung cancer_Homo sapiens_hsa052220.35084922
98Nitrogen metabolism_Homo sapiens_hsa009100.34650720
99Toxoplasmosis_Homo sapiens_hsa051450.31707765
100ECM-receptor interaction_Homo sapiens_hsa045120.31557112
101Nicotine addiction_Homo sapiens_hsa050330.31549068
102beta-Alanine metabolism_Homo sapiens_hsa004100.30425821
103Endometrial cancer_Homo sapiens_hsa052130.30246671
104Fatty acid metabolism_Homo sapiens_hsa012120.29643153
105Amoebiasis_Homo sapiens_hsa051460.28291857
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.27527923
107Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27317232
108Selenocompound metabolism_Homo sapiens_hsa004500.26310856
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26078629
110Other glycan degradation_Homo sapiens_hsa005110.24084109
111Oxidative phosphorylation_Homo sapiens_hsa001900.24046100
112Hippo signaling pathway_Homo sapiens_hsa043900.23907397
113Legionellosis_Homo sapiens_hsa051340.23275609
114Shigellosis_Homo sapiens_hsa051310.22625570
115Inositol phosphate metabolism_Homo sapiens_hsa005620.21981101
116Proteoglycans in cancer_Homo sapiens_hsa052050.21447384
117* Metabolic pathways_Homo sapiens_hsa011000.21438007
118Arginine and proline metabolism_Homo sapiens_hsa003300.20841536
119Propanoate metabolism_Homo sapiens_hsa006400.20621007
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18490846
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18242052
122Focal adhesion_Homo sapiens_hsa045100.16661226
123Cocaine addiction_Homo sapiens_hsa050300.15726137
124Insulin resistance_Homo sapiens_hsa049310.15123086
125Dorso-ventral axis formation_Homo sapiens_hsa043200.14870258
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12422208
127Staphylococcus aureus infection_Homo sapiens_hsa051500.12175772
128Sulfur relay system_Homo sapiens_hsa041220.12072750
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11948101
130Influenza A_Homo sapiens_hsa051640.11571699
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.10884659
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.10185497
133Olfactory transduction_Homo sapiens_hsa047400.09627730
134Cardiac muscle contraction_Homo sapiens_hsa042600.08342333

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