GCNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)8.34117919
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G7.30802308
3platelet dense granule organization (GO:0060155)6.74527935
4regulation of gene silencing by RNA (GO:0060966)6.41190790
5regulation of posttranscriptional gene silencing (GO:0060147)6.41190790
6regulation of gene silencing by miRNA (GO:0060964)6.41190790
7antigen processing and presentation via MHC class Ib (GO:0002475)6.18783448
8megakaryocyte development (GO:0035855)5.86008481
9negative regulation of erythrocyte differentiation (GO:0045647)5.59671542
10endosome to pigment granule transport (GO:0043485)5.24101271
11endosome to melanosome transport (GO:0035646)5.24101271
12mature B cell differentiation involved in immune response (GO:0002313)5.20760668
13ribosomal small subunit assembly (GO:0000028)5.19359970
14phospholipid scrambling (GO:0017121)4.96291155
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86229168
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.86229168
17necroptotic process (GO:0070266)4.29160770
18lymphoid progenitor cell differentiation (GO:0002320)4.28035511
19regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22978080
20positive regulation of B cell differentiation (GO:0045579)4.16776216
21establishment of integrated proviral latency (GO:0075713)4.15188336
22doxorubicin metabolic process (GO:0044598)4.09196294
23daunorubicin metabolic process (GO:0044597)4.09196294
24polyketide metabolic process (GO:0030638)4.09196294
25secretory granule organization (GO:0033363)4.05867000
26lymph node development (GO:0048535)3.98024378
27DNA double-strand break processing (GO:0000729)3.93468188
28response to interferon-beta (GO:0035456)3.93142819
29response to interferon-alpha (GO:0035455)3.89197854
30positive regulation of T cell mediated cytotoxicity (GO:0001916)3.85521059
31antigen processing and presentation of endogenous antigen (GO:0019883)3.82597169
32negative regulation of nitric oxide biosynthetic process (GO:0045019)3.78832963
33mature B cell differentiation (GO:0002335)3.75744955
34positive regulation of gamma-delta T cell activation (GO:0046645)3.72241304
35response to protozoan (GO:0001562)3.70164847
36regulation of DNA endoreduplication (GO:0032875)3.69225720
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.67079172
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.67079172
39regulation of translation, ncRNA-mediated (GO:0045974)3.67079172
40mitotic metaphase plate congression (GO:0007080)3.64446732
41defense response to protozoan (GO:0042832)3.62248028
42regulation of mitotic spindle checkpoint (GO:1903504)3.60294066
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60294066
44heparin biosynthetic process (GO:0030210)3.59734251
45heparin metabolic process (GO:0030202)3.59734251
46cell fate commitment involved in formation of primary germ layer (GO:0060795)3.55895607
47pre-miRNA processing (GO:0031054)3.55414391
48regulation of B cell differentiation (GO:0045577)3.52959592
49regulation of natural killer cell differentiation (GO:0032823)3.52888131
50cellular response to thyroid hormone stimulus (GO:0097067)3.51692573
51regulation of T cell mediated cytotoxicity (GO:0001914)3.49058232
52chromatin remodeling at centromere (GO:0031055)3.46144378
53regulation of gene silencing (GO:0060968)3.44646473
54negative regulation of glycoprotein biosynthetic process (GO:0010561)3.41524298
55L-fucose catabolic process (GO:0042355)3.40304957
56fucose catabolic process (GO:0019317)3.40304957
57L-fucose metabolic process (GO:0042354)3.40304957
58negative regulation of DNA-dependent DNA replication (GO:2000104)3.40276962
59cytokine production involved in immune response (GO:0002367)3.38160676
60response to type I interferon (GO:0034340)3.36808002
61somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36053271
62somatic hypermutation of immunoglobulin genes (GO:0016446)3.36053271
63type I interferon signaling pathway (GO:0060337)3.34258027
64cellular response to type I interferon (GO:0071357)3.34258027
65L-serine metabolic process (GO:0006563)3.34060799
66lysine metabolic process (GO:0006553)3.30809156
67lysine catabolic process (GO:0006554)3.30809156
68metaphase plate congression (GO:0051310)3.30618960
69regulation of helicase activity (GO:0051095)3.28970287
70angiogenesis involved in wound healing (GO:0060055)3.26118677
71negative regulation of gene silencing (GO:0060969)3.22480817
72viral transcription (GO:0019083)3.21716365
73CENP-A containing nucleosome assembly (GO:0034080)3.21178623
74regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.21139045
75establishment of viral latency (GO:0019043)3.20769922
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.19338043
77response to X-ray (GO:0010165)3.18882442
78immunoglobulin mediated immune response (GO:0016064)3.18761016
79Peyers patch development (GO:0048541)3.18349212
80mucosal-associated lymphoid tissue development (GO:0048537)3.18349212
81T-helper 1 type immune response (GO:0042088)3.16356639
82programmed necrotic cell death (GO:0097300)3.15791446
83negative regulation of T-helper cell differentiation (GO:0045623)3.15197281
84negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.15197281
85macrophage differentiation (GO:0030225)3.12387400
86thrombin receptor signaling pathway (GO:0070493)3.09041280
87mitotic sister chromatid cohesion (GO:0007064)3.08920707
88detection of bacterium (GO:0016045)3.08627128
89translational termination (GO:0006415)3.08349188
90L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08258811
91regulation of hippo signaling (GO:0035330)3.05372289
92positive regulation of granulocyte differentiation (GO:0030854)3.05289168
93B cell differentiation (GO:0030183)3.04066747
94aspartate family amino acid catabolic process (GO:0009068)3.02286352
95protein localization to kinetochore (GO:0034501)3.02125132
96positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.01410090
97regulation of gamma-delta T cell differentiation (GO:0045586)3.00901011
98regulation of erythrocyte differentiation (GO:0045646)2.99498379
99histone exchange (GO:0043486)2.97556489
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.97538962
101embryonic hemopoiesis (GO:0035162)2.97354539
102detection of other organism (GO:0098543)2.96585940
103non-recombinational repair (GO:0000726)2.96055517
104double-strand break repair via nonhomologous end joining (GO:0006303)2.96055517
105positive regulation of macrophage differentiation (GO:0045651)2.94342846
106microtubule depolymerization (GO:0007019)2.94276539
107positive regulation of respiratory burst (GO:0060267)2.93332634
108toxin transport (GO:1901998)2.93078173
109negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.92094320
110aminoglycoside antibiotic metabolic process (GO:0030647)2.91633639
111mast cell activation (GO:0045576)2.91630832
112T cell homeostasis (GO:0043029)2.91435014
113water-soluble vitamin biosynthetic process (GO:0042364)2.90868720
114protein localization to chromosome, centromeric region (GO:0071459)2.89992461
115DNA replication-dependent nucleosome organization (GO:0034723)2.89430164
116DNA replication-dependent nucleosome assembly (GO:0006335)2.89430164
117negative regulation of DNA recombination (GO:0045910)2.85322897
118somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.83296631
119isotype switching (GO:0045190)2.83296631
120somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.83296631
121necrotic cell death (GO:0070265)2.82771868
122regulation of natural killer cell activation (GO:0032814)2.82151865
123positive regulation of SMAD protein import into nucleus (GO:0060391)2.80825356
124regulation of gamma-delta T cell activation (GO:0046643)2.80132242
125regulation of spindle checkpoint (GO:0090231)2.79992549
126mast cell activation involved in immune response (GO:0002279)2.77138658
127mast cell degranulation (GO:0043303)2.77138658
128myeloid dendritic cell activation (GO:0001773)2.77095853
129regulation of RIG-I signaling pathway (GO:0039535)2.76775716
130respiratory chain complex IV assembly (GO:0008535)2.76579578
131regulation of centriole replication (GO:0046599)2.76441693
132kidney morphogenesis (GO:0060993)2.75200435
133negative regulation of viral genome replication (GO:0045071)2.74920226
134histamine transport (GO:0051608)2.73776286
135regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.73607572
136spindle checkpoint (GO:0031577)2.73230696
137activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.72113247
138translational elongation (GO:0006414)2.71827335
139positive regulation of natural killer cell differentiation (GO:0032825)2.70189881
140leukocyte homeostasis (GO:0001776)2.69424886
141positive regulation of natural killer cell activation (GO:0032816)2.69404529
142SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.69215770
143female gonad development (GO:0008585)2.69205461
144replication fork processing (GO:0031297)2.68573957
145L-methionine salvage (GO:0071267)2.67778035
146L-methionine biosynthetic process (GO:0071265)2.67778035
147amino acid salvage (GO:0043102)2.67778035
148glycoside metabolic process (GO:0016137)2.67204180
149regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.66626009
150mitotic spindle checkpoint (GO:0071174)2.64753552
151regulation of chromatin silencing (GO:0031935)2.63398975
152positive regulation of glycoprotein biosynthetic process (GO:0010560)2.63393446
153regulation of cofactor metabolic process (GO:0051193)2.63074449
154regulation of coenzyme metabolic process (GO:0051196)2.63074449
155dorsal/ventral axis specification (GO:0009950)2.63063683
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.62643076
157negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62129604
158negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62129604
159negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62129604
160negative regulation of mitotic sister chromatid separation (GO:2000816)2.62129604
161negative regulation of sister chromatid segregation (GO:0033046)2.62129604
162myeloid cell development (GO:0061515)2.62063542
163regulation of cell fate specification (GO:0042659)2.61801437
164single strand break repair (GO:0000012)2.61566452
165negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.61162525
166bundle of His cell to Purkinje myocyte communication (GO:0086069)2.60548798
167cotranslational protein targeting to membrane (GO:0006613)2.60113798
168JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59213924
169production of molecular mediator involved in inflammatory response (GO:0002532)2.59173298
170response to thyroid hormone (GO:0097066)2.58883095
171regulation of acyl-CoA biosynthetic process (GO:0050812)2.58383978
172nodal signaling pathway (GO:0038092)2.58274187
173interferon-gamma-mediated signaling pathway (GO:0060333)2.58252649
174RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57546079
175negative regulation of chromosome segregation (GO:0051985)2.57480375
176kynurenine metabolic process (GO:0070189)2.57454688
177cytochrome complex assembly (GO:0017004)2.55303324
178ncRNA catabolic process (GO:0034661)2.53444238
179DNA ligation (GO:0006266)2.53196897
180presynaptic membrane assembly (GO:0097105)2.49278738
181nuclear pore complex assembly (GO:0051292)2.48564898
182DNA replication-independent nucleosome assembly (GO:0006336)2.45510120
183DNA replication-independent nucleosome organization (GO:0034724)2.45510120
184DNA replication checkpoint (GO:0000076)2.45503811
185mitotic G2/M transition checkpoint (GO:0044818)2.42783156
186regulation of mitotic metaphase/anaphase transition (GO:0030071)2.42162194
187regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.42162194
188histone H2A acetylation (GO:0043968)2.41970826
189regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41508795
190DNA strand renaturation (GO:0000733)2.40475010
191lung-associated mesenchyme development (GO:0060484)2.39199805
192nuclear pore organization (GO:0006999)2.39009223
193regulation of sulfur metabolic process (GO:0042762)2.38572031
194somatic diversification of immunoglobulins (GO:0016445)2.37858482
195L-alpha-amino acid transmembrane transport (GO:1902475)2.37325006
196regulation of chromosome segregation (GO:0051983)2.37243812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* SCL_19346495_ChIP-Seq_HPC-7_Human5.71908181
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.86628833
3* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.06384671
4* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.91868919
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.75202239
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73434698
7GATA1_22025678_ChIP-Seq_K562_Human3.66951656
8* LYL1_20887958_ChIP-Seq_HPC-7_Mouse3.63664192
9E2F7_22180533_ChIP-Seq_HELA_Human3.40356793
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.38980568
11ZNF274_21170338_ChIP-Seq_K562_Hela3.25624254
12* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.20989725
13NOTCH1_21737748_ChIP-Seq_TLL_Human3.19867937
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08881970
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.84187855
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.78540827
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.74320212
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73233339
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.67444654
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.67250803
21FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.63151519
22* LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.62569385
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.51271253
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.45382102
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44633615
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.43313331
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41699448
28VDR_22108803_ChIP-Seq_LS180_Human2.37299331
29* GATA2_21666600_ChIP-Seq_HMVEC_Human2.35461247
30RUNX_20019798_ChIP-Seq_JUKART_Human2.34208097
31* GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.28960849
32SPI1_23547873_ChIP-Seq_NB4_Human2.28329902
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26692559
34EWS_26573619_Chip-Seq_HEK293_Human2.25715182
35* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.25340881
36FUS_26573619_Chip-Seq_HEK293_Human2.24285009
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18138745
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16292255
39RUNX1_22412390_ChIP-Seq_EML_Mouse2.15515376
40FLI1_27457419_Chip-Seq_LIVER_Mouse2.12298844
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.11583642
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11107084
43MYB_26560356_Chip-Seq_TH2_Human2.09557192
44* P300_19829295_ChIP-Seq_ESCs_Human2.08368048
45BP1_19119308_ChIP-ChIP_Hs578T_Human2.08335379
46ERG_20887958_ChIP-Seq_HPC-7_Mouse2.06748885
47STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05908366
48TAF15_26573619_Chip-Seq_HEK293_Human2.05369001
49ELK1_19687146_ChIP-ChIP_HELA_Human2.03430939
50IGF1R_20145208_ChIP-Seq_DFB_Human2.02945595
51* TCF7_22412390_ChIP-Seq_EML_Mouse1.99517325
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98905440
53* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93042101
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92397454
55VDR_21846776_ChIP-Seq_THP-1_Human1.89973404
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89972073
57MYB_26560356_Chip-Seq_TH1_Human1.88018898
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86987760
59VDR_24763502_ChIP-Seq_THP-1_Human1.86189335
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84398663
61GBX2_23144817_ChIP-Seq_PC3_Human1.83696778
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.83595360
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83198069
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.81156355
65MYC_22102868_ChIP-Seq_BL_Human1.80643493
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.80022016
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.79943994
68* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79765049
69FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79052540
70* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77978118
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.77532269
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.77388969
73MAF_26560356_Chip-Seq_TH1_Human1.76355353
74IRF8_27001747_Chip-Seq_BMDM_Mouse1.74878226
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72023791
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.71187102
77SPI1_23127762_ChIP-Seq_K562_Human1.70627308
78* SOX2_16153702_ChIP-ChIP_HESCs_Human1.70422449
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70005018
80* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.68619174
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67706025
82* NANOG_16153702_ChIP-ChIP_HESCs_Human1.63956273
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62810004
84BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58443403
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54437032
86AR_21909140_ChIP-Seq_LNCAP_Human1.52540058
87IRF1_19129219_ChIP-ChIP_H3396_Human1.50297747
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49173794
89* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.48593891
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46865556
91ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45504558
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44399297
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42950352
94PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38952863
95UTX_26944678_Chip-Seq_JUKART_Human1.37862748
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37223448
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.36740090
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35266591
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34551127
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33908139
101MYC_18940864_ChIP-ChIP_HL60_Human1.33383338
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33308917
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33275144
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32673912
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32591461
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31896145
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31043140
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.27861134
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27632075
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26643180
111STAT3_23295773_ChIP-Seq_U87_Human1.25967397
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.25265119
113VDR_23849224_ChIP-Seq_CD4+_Human1.25089445
114SMAD4_21799915_ChIP-Seq_A2780_Human1.24346206
115ETS1_22383799_ChIP-Seq_G1ME_Mouse1.24194134
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.23078208
117GATA3_27048872_Chip-Seq_THYMUS_Human1.22680822
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22237988
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21634536
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19928405
121ESR1_21235772_ChIP-Seq_MCF-7_Human1.19433152
122GATA1_19941826_ChIP-Seq_K562_Human1.18637924
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16653871
124* TCF4_22108803_ChIP-Seq_LS180_Human1.16226522
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14792415
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14674927
127* GATA2_19941826_ChIP-Seq_K562_Human1.14664568
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14098085
129SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13256972
130RXR_22158963_ChIP-Seq_LIVER_Mouse1.13225587
131NFE2_27457419_Chip-Seq_LIVER_Mouse1.12514298
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12147213
133NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12094959
134* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10713237
135* CDX2_22108803_ChIP-Seq_LS180_Human1.10628999
136* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09847979
137E2F1_21310950_ChIP-Seq_MCF-7_Human1.09448241
138Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09278133
139CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09224517
140SMAD3_21741376_ChIP-Seq_EPCs_Human1.08861631
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08618749
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08393287
143TCF4_23295773_ChIP-Seq_U87_Human1.06947939
144* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06780530
145FOXP3_21729870_ChIP-Seq_TREG_Human1.06680385
146CBP_20019798_ChIP-Seq_JUKART_Human1.06035147
147IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06035147
148* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.05909869
149ELK3_25401928_ChIP-Seq_HUVEC_Human1.04937004
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04674830
151TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04276553
152* GATA3_26560356_Chip-Seq_TH2_Human1.04116853
153NANOG_19829295_ChIP-Seq_ESCs_Human1.04067094
154SOX2_19829295_ChIP-Seq_ESCs_Human1.04067094
155BCAT_22108803_ChIP-Seq_LS180_Human1.03882187
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03561025
157ETS1_20019798_ChIP-Seq_JURKAT_Human1.03050086
158TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02412264
159MYC_18555785_ChIP-Seq_MESCs_Mouse1.02401023
160* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02024647
161* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01601626
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00534112
163POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00534112
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99696974
165RUNX2_22187159_ChIP-Seq_PCA_Human0.97755167
166TP53_22573176_ChIP-Seq_HFKS_Human0.97013429
167* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95588231
168NCOR1_26117541_ChIP-Seq_K562_Human0.95064375
169JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94659275
170* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94510858
171* PU_27001747_Chip-Seq_BMDM_Mouse0.94332816
172TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92914598
173SRF_21415370_ChIP-Seq_HL-1_Mouse0.92737838
174CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91403467
175NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91285408
176RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91254395
177RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91212424
178AR_25329375_ChIP-Seq_VCAP_Human0.91015587
179SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90784623
180FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.90328569
181PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86823738
182SOX2_20726797_ChIP-Seq_SW620_Human0.86810942
183* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.86561455
184EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.84989415
185PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84023720
186ZNF263_19887448_ChIP-Seq_K562_Human0.83422256
187NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.83234808
188SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82585426
189PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80317726
190MAF_26560356_Chip-Seq_TH2_Human0.78189689
191HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75918125
192ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75253976
193AR_20517297_ChIP-Seq_VCAP_Human0.73980642
194* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73480910
195BCL6_27268052_Chip-Seq_Bcells_Human0.71842985
196* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71639716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity4.09828176
2MP0002396_abnormal_hematopoietic_system3.73794144
3MP0003693_abnormal_embryo_hatching3.36813348
4MP0008877_abnormal_DNA_methylation3.29553405
5MP0003195_calcinosis3.24103059
6MP0003890_abnormal_embryonic-extraembry3.10404734
7MP0008057_abnormal_DNA_replication3.09169569
8MP0001545_abnormal_hematopoietic_system2.93044804
9MP0005397_hematopoietic_system_phenotyp2.93044804
10MP0005174_abnormal_tail_pigmentation2.87840676
11MP0009785_altered_susceptibility_to2.86061578
12MP0004808_abnormal_hematopoietic_stem2.81010613
13MP0005464_abnormal_platelet_physiology2.77776866
14MP0003718_maternal_effect2.72027670
15MP0000685_abnormal_immune_system2.67317419
16MP0003724_increased_susceptibility_to2.66560320
17MP0001835_abnormal_antigen_presentation2.65056445
18MP0009278_abnormal_bone_marrow2.63710479
19MP0005075_abnormal_melanosome_morpholog2.58376063
20MP0004147_increased_porphyrin_level2.56224835
21MP0002837_dystrophic_cardiac_calcinosis2.54294487
22MP0000569_abnormal_digit_pigmentation2.53804529
23MP0003136_yellow_coat_color2.50326726
24MP0000465_gastrointestinal_hemorrhage2.37256391
25MP0008058_abnormal_DNA_repair2.36988492
26MP0010094_abnormal_chromosome_stability2.32897808
27MP0003646_muscle_fatigue2.26111386
28MP0003191_abnormal_cellular_cholesterol2.10813831
29MP0003436_decreased_susceptibility_to2.08222277
30MP0001293_anophthalmia2.07680166
31MP0004957_abnormal_blastocyst_morpholog2.05330910
32MP0002102_abnormal_ear_morphology2.04562669
33MP0005671_abnormal_response_to1.98435835
34MP0003866_abnormal_defecation1.96198777
35MP0002877_abnormal_melanocyte_morpholog1.95000866
36MP0003567_abnormal_fetal_cardiomyocyte1.92241879
37MP0001188_hyperpigmentation1.91335180
38MP0005025_abnormal_response_to1.90848488
39MP0010368_abnormal_lymphatic_system1.86129532
40MP0006072_abnormal_retinal_apoptosis1.84988297
41MP0004133_heterotaxia1.84407512
42MP0003111_abnormal_nucleus_morphology1.82744441
43MP0010155_abnormal_intestine_physiology1.80816181
44MP0002938_white_spotting1.80772206
45MP0006292_abnormal_olfactory_placode1.72870727
46MP0005253_abnormal_eye_physiology1.72076051
47MP0002095_abnormal_skin_pigmentation1.71146352
48MP0006054_spinal_hemorrhage1.70966357
49MP0003943_abnormal_hepatobiliary_system1.68332943
50MP0003077_abnormal_cell_cycle1.66336112
51MP0004264_abnormal_extraembryonic_tissu1.65518303
52MP0001800_abnormal_humoral_immune1.62877423
53MP0006035_abnormal_mitochondrial_morpho1.62441497
54MP0002723_abnormal_immune_serum1.62006450
55MP0003937_abnormal_limbs/digits/tail_de1.60391314
56MP0003787_abnormal_imprinting1.59211530
57MP0002398_abnormal_bone_marrow1.58904455
58MP0002148_abnormal_hypersensitivity_rea1.57975307
59MP0008932_abnormal_embryonic_tissue1.57519402
60MP0002653_abnormal_ependyma_morphology1.57436001
61MP0003119_abnormal_digestive_system1.56475673
62MP0000490_abnormal_crypts_of1.55471684
63MP0001853_heart_inflammation1.52530530
64MP0002420_abnormal_adaptive_immunity1.49540647
65MP0003868_abnormal_feces_composition1.49310596
66MP0001819_abnormal_immune_cell1.47872907
67MP0002419_abnormal_innate_immunity1.47508215
68MP0002452_abnormal_antigen_presenting1.46483079
69MP0005000_abnormal_immune_tolerance1.42803410
70MP0005551_abnormal_eye_electrophysiolog1.42678917
71MP0004215_abnormal_myocardial_fiber1.42520765
72MP0008875_abnormal_xenobiotic_pharmacok1.40382190
73MP0009764_decreased_sensitivity_to1.35448706
74MP0000689_abnormal_spleen_morphology1.33144334
75MP0003763_abnormal_thymus_physiology1.32660472
76MP0001873_stomach_inflammation1.31276321
77MP0001790_abnormal_immune_system1.29111406
78MP0005387_immune_system_phenotype1.29111406
79MP0004947_skin_inflammation1.28660834
80* MP0000716_abnormal_immune_system1.28461390
81MP0002166_altered_tumor_susceptibility1.27164030
82MP0001968_abnormal_touch/_nociception1.26644391
83MP0003121_genomic_imprinting1.25939111
84MP0001286_abnormal_eye_development1.25353630
85MP0001845_abnormal_inflammatory_respons1.24855032
86MP0009765_abnormal_xenobiotic_induced1.24047563
87MP0008469_abnormal_protein_level1.23955076
88* MP0002429_abnormal_blood_cell1.23010869
89MP0001529_abnormal_vocalization1.21885320
90MP0001324_abnormal_eye_pigmentation1.19661671
91MP0002722_abnormal_immune_system1.19214368
92MP0003300_gastrointestinal_ulcer1.18317598
93MP0002928_abnormal_bile_duct1.18122052
94MP0008775_abnormal_heart_ventricle1.17268227
95MP0005365_abnormal_bile_salt1.16784946
96MP0000647_abnormal_sebaceous_gland1.16556286
97MP0003638_abnormal_response/metabolism_1.15771257
98MP0002090_abnormal_vision1.15592551
99MP0002735_abnormal_chemical_nociception1.15423044
100MP0005395_other_phenotype1.14502522
101MP0001485_abnormal_pinna_reflex1.14020075
102MP0009672_abnormal_birth_weight1.13965062
103MP0000343_altered_response_to1.12424280
104MP0005084_abnormal_gallbladder_morpholo1.11144910
105MP0009379_abnormal_foot_pigmentation1.11025847
106MP0004043_abnormal_pH_regulation1.09853345
107MP0004197_abnormal_fetal_growth/weight/1.09070244
108MP0005167_abnormal_blood-brain_barrier1.09001232
109MP0002697_abnormal_eye_size1.08998695
110MP0000681_abnormal_thyroid_gland1.08567341
111MP0002405_respiratory_system_inflammati1.08273761
112MP0002084_abnormal_developmental_patter1.05864498
113MP0005391_vision/eye_phenotype1.05540522
114MP0001672_abnormal_embryogenesis/_devel1.05472124
115MP0005380_embryogenesis_phenotype1.05472124
116MP0000372_irregular_coat_pigmentation1.04151767
117MP0002736_abnormal_nociception_after1.03911161
118MP0004084_abnormal_cardiac_muscle1.03720474
119MP0006276_abnormal_autonomic_nervous1.03168499
120MP0002233_abnormal_nose_morphology1.02849785
121MP0003828_pulmonary_edema1.00367709
122MP0005085_abnormal_gallbladder_physiolo1.00139715
123MP0005367_renal/urinary_system_phenotyp0.98957610
124MP0000516_abnormal_urinary_system0.98957610
125MP0001984_abnormal_olfaction0.97063748
126MP0008789_abnormal_olfactory_epithelium0.96524043
127MP0003984_embryonic_growth_retardation0.95959901
128MP0003172_abnormal_lysosome_physiology0.95727224
129MP0002132_abnormal_respiratory_system0.95489649
130MP0000015_abnormal_ear_pigmentation0.94525440
131MP0002088_abnormal_embryonic_growth/wei0.94382265
132MP0003075_altered_response_to0.93829253
133MP0001730_embryonic_growth_arrest0.93288369
134MP0009703_decreased_birth_body0.93058190
135MP0010234_abnormal_vibrissa_follicle0.92247797
136MP0002085_abnormal_embryonic_tissue0.91414491
137* MP0005332_abnormal_amino_acid0.89962563
138MP0001879_abnormal_lymphatic_vessel0.89919254
139MP0003806_abnormal_nucleotide_metabolis0.89220856
140MP0001697_abnormal_embryo_size0.88522594
141MP0002254_reproductive_system_inflammat0.88341449
142MP0008007_abnormal_cellular_replicative0.88286921
143MP0010352_gastrointestinal_tract_polyps0.87935290
144MP0003137_abnormal_impulse_conducting0.87925728
145MP0003183_abnormal_peptide_metabolism0.87798456
146MP0009046_muscle_twitch0.86550543
147MP0005195_abnormal_posterior_eye0.85690653
148MP0002693_abnormal_pancreas_physiology0.85507521
149MP0003122_maternal_imprinting0.83410002
150MP0000358_abnormal_cell_content/0.82465146
151MP0003656_abnormal_erythrocyte_physiolo0.81905843
152MP0001348_abnormal_lacrimal_gland0.80765288
153MP0001533_abnormal_skeleton_physiology0.80409674
154MP0002006_tumorigenesis0.79854400
155MP0009763_increased_sensitivity_to0.78837738
156MP0008004_abnormal_stomach_pH0.78468318
157MP0008874_decreased_physiological_sensi0.77764002
158MP0005408_hypopigmentation0.76819428
159MP0003221_abnormal_cardiomyocyte_apopto0.76290400
160MP0005499_abnormal_olfactory_system0.73518634
161MP0005394_taste/olfaction_phenotype0.73518634
162MP0000477_abnormal_intestine_morphology0.73284230
163MP0000703_abnormal_thymus_morphology0.73090246
164MP0001929_abnormal_gametogenesis0.73061015
165MP0003861_abnormal_nervous_system0.72690905
166MP0000537_abnormal_urethra_morphology0.72580509
167MP0003941_abnormal_skin_development0.71719985
168MP0000678_abnormal_parathyroid_gland0.71657422
169MP0001666_abnormal_nutrient_absorption0.71513049
170MP0002638_abnormal_pupillary_reflex0.71367849
171MP0005409_darkened_coat_color0.71217329
172MP0010329_abnormal_lipoprotein_level0.71091768
173MP0005379_endocrine/exocrine_gland_phen0.70879333
174MP0009697_abnormal_copulation0.70672996
175MP0002111_abnormal_tail_morphology0.70480214
176MP0002138_abnormal_hepatobiliary_system0.70197649
177MP0000631_abnormal_neuroendocrine_gland0.70049161
178MP0002751_abnormal_autonomic_nervous0.69906003
179MP0004085_abnormal_heartbeat0.69436366
180MP0000598_abnormal_liver_morphology0.69338455
181MP0009643_abnormal_urine_homeostasis0.69235456
182MP0001145_abnormal_male_reproductive0.68567590
183MP0005171_absent_coat_pigmentation0.67131254
184MP0003755_abnormal_palate_morphology0.67099766
185MP0002080_prenatal_lethality0.66392973

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.66460361
2Hypothermia (HP:0002045)4.61389994
3Myositis (HP:0100614)4.48762255
4Prolonged bleeding time (HP:0003010)4.35270841
5Aplastic anemia (HP:0001915)4.19536196
6IgM deficiency (HP:0002850)3.92241049
7Interstitial pulmonary disease (HP:0006530)3.82419074
8Acute myeloid leukemia (HP:0004808)3.72918196
9Abnormality of the labia minora (HP:0012880)3.69205136
10Epistaxis (HP:0000421)3.68012763
11Hypoproteinemia (HP:0003075)3.55564783
12Elevated erythrocyte sedimentation rate (HP:0003565)3.54609069
13Chronic otitis media (HP:0000389)3.42785815
14Petechiae (HP:0000967)3.13332240
15Acute lymphatic leukemia (HP:0006721)3.12486758
16Impaired platelet aggregation (HP:0003540)3.06293038
17Abnormal platelet function (HP:0011869)3.06293038
18Abnormality of cells of the erythroid lineage (HP:0012130)3.05920166
19Reduced antithrombin III activity (HP:0001976)3.03696978
20Orchitis (HP:0100796)3.02143726
21Episodic fever (HP:0001954)2.88755180
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88747214
23Gingival bleeding (HP:0000225)2.88044400
24Hyperglycinemia (HP:0002154)2.85342597
25Abnormal number of erythroid precursors (HP:0012131)2.82182903
26Generalized aminoaciduria (HP:0002909)2.79696503
27Erythema (HP:0010783)2.79277745
28Abnormality of the heme biosynthetic pathway (HP:0010472)2.79044448
29Intestinal atresia (HP:0011100)2.78399279
30Increased IgE level (HP:0003212)2.76222103
31Hyperglycinuria (HP:0003108)2.72668722
32Abnormality of the nasal mucosa (HP:0000433)2.72504533
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.71036466
34True hermaphroditism (HP:0010459)2.69575244
35Abnormality of T cell physiology (HP:0011840)2.69161581
36Pancreatic fibrosis (HP:0100732)2.64329634
37Hematochezia (HP:0002573)2.62218565
38Polygenic inheritance (HP:0010982)2.61942918
39Chronic hepatic failure (HP:0100626)2.59927871
40Abnormality of glycine metabolism (HP:0010895)2.58699852
41Abnormality of serine family amino acid metabolism (HP:0010894)2.58699852
42Pancreatic cysts (HP:0001737)2.57797509
43Type I transferrin isoform profile (HP:0003642)2.56776972
44Cortical dysplasia (HP:0002539)2.55503485
45Lip pit (HP:0100267)2.54268659
46Spontaneous hematomas (HP:0007420)2.53835434
47Amaurosis fugax (HP:0100576)2.50125356
48Arterial thrombosis (HP:0004420)2.49200847
49Abnormality of midbrain morphology (HP:0002418)2.47805281
50Molar tooth sign on MRI (HP:0002419)2.47805281
51Colon cancer (HP:0003003)2.46396173
52Menorrhagia (HP:0000132)2.41358493
53Hyperlipoproteinemia (HP:0010980)2.38600812
54Pendular nystagmus (HP:0012043)2.37180829
55Abnormality of serum amino acid levels (HP:0003112)2.37073418
56Optic neuritis (HP:0100653)2.36785987
57Retrobulbar optic neuritis (HP:0100654)2.36785987
58Abolished electroretinogram (ERG) (HP:0000550)2.35832631
59Birth length less than 3rd percentile (HP:0003561)2.34046641
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.32118170
61Recurrent bronchitis (HP:0002837)2.31557308
62Albinism (HP:0001022)2.31497030
63Abnormality of macrophages (HP:0004311)2.30455012
64Abnormal protein glycosylation (HP:0012346)2.27513244
65Abnormal glycosylation (HP:0012345)2.27513244
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27513244
67Abnormal protein N-linked glycosylation (HP:0012347)2.27513244
68Gastrointestinal inflammation (HP:0004386)2.24954640
69Nephronophthisis (HP:0000090)2.23727655
70Vacuolated lymphocytes (HP:0001922)2.23554143
71Panhypogammaglobulinemia (HP:0003139)2.22990314
72Abnormality of chromosome stability (HP:0003220)2.22751183
73Nephroblastoma (Wilms tumor) (HP:0002667)2.20425102
74Inflammation of the large intestine (HP:0002037)2.20364511
75Meckel diverticulum (HP:0002245)2.19635268
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19278479
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18275911
78Spontaneous abortion (HP:0005268)2.18128301
79Broad face (HP:0000283)2.17253741
80Portal hypertension (HP:0001409)2.16761961
81Ependymoma (HP:0002888)2.16114610
82Spastic diplegia (HP:0001264)2.14928233
83Supernumerary spleens (HP:0009799)2.12378336
84Bilateral microphthalmos (HP:0007633)2.12315271
85Methylmalonic acidemia (HP:0002912)2.12023761
86Abnormal biliary tract physiology (HP:0012439)2.11936401
87Bile duct proliferation (HP:0001408)2.11936401
88Chronic bronchitis (HP:0004469)2.11842061
89Abnormality of the ileum (HP:0001549)2.11806167
90Embryonal renal neoplasm (HP:0011794)2.11020934
91Purpura (HP:0000979)2.10188140
92Recurrent abscess formation (HP:0002722)2.09668258
93Growth hormone excess (HP:0000845)2.09323356
94Progressive neurologic deterioration (HP:0002344)2.09165976
95Hepatoblastoma (HP:0002884)2.09160588
96Anophthalmia (HP:0000528)2.08827188
97Chromsome breakage (HP:0040012)2.08772343
98Cellulitis (HP:0100658)2.08580954
99Progressive inability to walk (HP:0002505)2.08139761
100Beaking of vertebral bodies (HP:0004568)2.08090541
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07550006
102Abnormality of alanine metabolism (HP:0010916)2.07550006
103Hyperalaninemia (HP:0003348)2.07550006
104Bruising susceptibility (HP:0000978)2.05684965
105Volvulus (HP:0002580)2.02836305
106Absent/shortened dynein arms (HP:0200106)2.01841776
107Dynein arm defect of respiratory motile cilia (HP:0012255)2.01841776
108Absent rod-and cone-mediated responses on ERG (HP:0007688)2.01333042
109Medial flaring of the eyebrow (HP:0010747)2.00170793
110Abnormality of the hepatic vasculature (HP:0006707)1.99225272
111Vaginal atresia (HP:0000148)1.98967362
112Genital tract atresia (HP:0001827)1.98716189
113Recurrent bacterial skin infections (HP:0005406)1.98641918
114Myelodysplasia (HP:0002863)1.98600440
115Thyroid-stimulating hormone excess (HP:0002925)1.98500545
116Biliary tract neoplasm (HP:0100574)1.97093028
117Abnormality of the renal medulla (HP:0100957)1.97026036
118Abnormal lung lobation (HP:0002101)1.96821379
119Absent eyebrow (HP:0002223)1.96570833
120Abnormality of B cell number (HP:0010975)1.96337409
121B lymphocytopenia (HP:0010976)1.96337409
122Bifid tongue (HP:0010297)1.96150778
123Abnormality of the columella (HP:0009929)1.95672634
124Gastrointestinal stroma tumor (HP:0100723)1.94936300
125Spinal canal stenosis (HP:0003416)1.93606770
126Abnormality of methionine metabolism (HP:0010901)1.93096831
127Sloping forehead (HP:0000340)1.92309380
128Neoplasm of the adrenal gland (HP:0100631)1.91898310
129Recurrent fungal infections (HP:0002841)1.91709346
130Nonprogressive disorder (HP:0003680)1.91173531
131Anencephaly (HP:0002323)1.90765669
132Nephrogenic diabetes insipidus (HP:0009806)1.88712995
133Dandy-Walker malformation (HP:0001305)1.87950888
134Colitis (HP:0002583)1.87677650
135Congenital primary aphakia (HP:0007707)1.87490809
136Delayed CNS myelination (HP:0002188)1.87361985
137Tubulointerstitial nephritis (HP:0001970)1.86093980
138Thrombophlebitis (HP:0004418)1.85990995
139Hypoglycemic coma (HP:0001325)1.85888198
140Methylmalonic aciduria (HP:0012120)1.85818678
141Nasal polyposis (HP:0100582)1.85083045
142Keratitis (HP:0000491)1.85010381
143Septo-optic dysplasia (HP:0100842)1.83290323
144Microcytic anemia (HP:0001935)1.83250173
145Renal hypoplasia (HP:0000089)1.83110129
146Absent radius (HP:0003974)1.83020836
147Type 2 muscle fiber atrophy (HP:0003554)1.81880964
148Dysautonomia (HP:0002459)1.81871529
149Pancreatic islet-cell hyperplasia (HP:0004510)1.81489398
150Cupped ear (HP:0000378)1.80681335
151Abnormality of vitamin B metabolism (HP:0004340)1.80368187
152Poikiloderma (HP:0001029)1.80344298
153Aplasia/Hypoplasia of the uvula (HP:0010293)1.79978594
154Vasculitis (HP:0002633)1.79459539
155Lissencephaly (HP:0001339)1.79135804
156Neoplasm of the adrenal cortex (HP:0100641)1.78518794
157Aplasia/Hypoplasia of the fovea (HP:0008060)1.77904250
158Hypoplasia of the fovea (HP:0007750)1.77904250
159Decreased circulating renin level (HP:0003351)1.77877745
160Hypoplastic female external genitalia (HP:0012815)1.77823822
161Central scotoma (HP:0000603)1.77750811
162Aqueductal stenosis (HP:0002410)1.77463498
163Keratoconjunctivitis sicca (HP:0001097)1.77013188
164Broad-based gait (HP:0002136)1.76924719
165Cheilitis (HP:0100825)1.76893873
166Osteomyelitis (HP:0002754)1.76891605
167Abnormality of the duodenum (HP:0002246)1.76294725
168Gait imbalance (HP:0002141)1.76148283
169Hypoplasia of the thymus (HP:0000778)1.75974212
170Hyperpituitarism (HP:0010514)1.75973347
171Encephalitis (HP:0002383)1.75411701
172Bronchitis (HP:0012387)1.74856067
173Labial hypoplasia (HP:0000066)1.74844990
174Autoamputation (HP:0001218)1.74371329
175Rhabdomyosarcoma (HP:0002859)1.74099388
176Protruding tongue (HP:0010808)1.73917407
177Eczematoid dermatitis (HP:0000976)1.73669428
178Hyperventilation (HP:0002883)1.73525505
179Depressed nasal tip (HP:0000437)1.73488260
180Abnormality of the vitamin B12 metabolism (HP:0004341)1.73467887
181Chorioretinal atrophy (HP:0000533)1.72742419
182Preaxial hand polydactyly (HP:0001177)1.72730389
183Hypobetalipoproteinemia (HP:0003563)1.72529332
184Absent forearm bone (HP:0003953)1.71820127
185Aplasia involving forearm bones (HP:0009822)1.71820127
186Recurrent viral infections (HP:0004429)1.71536060
187Abnormal hair whorl (HP:0010721)1.71516623
188Broad foot (HP:0001769)1.71407426
189Aplasia/Hypoplasia of the tibia (HP:0005772)1.71216395
190Increased neuronal autofluorescent lipopigment (HP:0002074)1.71110299
191Stenosis of the external auditory canal (HP:0000402)1.69708778
192Scrotal hypoplasia (HP:0000046)1.69438829
193Neoplasm of the colon (HP:0100273)1.67907864
194Proximal tubulopathy (HP:0000114)1.66673160
195Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65920033
196Gastrointestinal atresia (HP:0002589)1.65795804
197Abnormality of the fovea (HP:0000493)1.65021507
198Hypoglycemic seizures (HP:0002173)1.65000220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT35.00472727
2KIT4.02099494
3MAP2K32.80023766
4TGFBR12.75405770
5MATK2.70863512
6TNIK2.64370975
7WNK32.59814881
8ZAK2.49210159
9MKNK22.41405937
10MAP3K122.38552962
11TTK2.38199127
12TGFBR22.32485503
13NEK12.29386312
14MAPKAPK32.25706301
15TIE12.24246936
16STK38L2.23858694
17PLK32.21959262
18TEC2.19651137
19BUB12.19193956
20CASK2.17390723
21ACVR1B2.11567497
22NUAK12.11214748
23SRPK12.10787505
24MAP3K62.10343640
25BTK2.08446304
26CDC72.06715091
27MKNK12.03402954
28TSSK61.94959486
29CSF1R1.93832608
30RIPK41.92735867
31TRIM281.90776470
32PLK41.84468431
33TRPM71.83271037
34MAP4K11.83186429
35NME21.81826602
36JAK31.78995580
37BCR1.76651563
38EEF2K1.68732314
39NLK1.66381205
40ADRBK21.64822345
41TAF11.64596416
42EIF2AK31.62426973
43ERBB41.59396555
44LATS11.54743251
45TAOK31.53817589
46RPS6KB21.53002369
47VRK21.52891696
48MAP2K61.50539701
49PBK1.48050365
50ZAP701.46803008
51BCKDK1.44797536
52PRKG21.44250564
53CSNK1G11.41911446
54BRSK21.40384779
55PLK11.35807406
56FGFR41.33740314
57TBK11.30825713
58MAPK151.28981695
59MAPKAPK51.28331947
60CAMKK21.23093099
61PIM21.22718524
62GRK11.19224245
63STK31.18272617
64RIPK11.17886932
65MAP4K21.16761319
66MAP3K41.16592970
67NEK21.15240055
68IKBKE1.14419003
69EPHA31.14199087
70PLK21.12082825
71EIF2AK11.11947609
72MUSK1.11481907
73CSNK1G31.11047502
74DYRK21.07890730
75PDK21.07674364
76OXSR11.07259851
77CSNK1G21.06492572
78SIK31.05490418
79CSNK1A1L1.03696872
80SYK1.03484174
81WEE10.98277710
82HIPK20.94907182
83RET0.94555405
84LRRK20.92902564
85BRSK10.92469742
86TXK0.92213936
87FES0.88398768
88FGFR30.86926536
89IKBKB0.85360250
90CHEK20.82814926
91ATM0.82412189
92MAP2K40.82044820
93TYK20.81389083
94EPHB10.80090914
95INSRR0.80060988
96PASK0.79853225
97MAP3K20.78061938
98CAMK1D0.78038892
99ATR0.77811486
100MAP3K10.76300037
101PRKCE0.74060029
102CAMK1G0.71964798
103AURKB0.70595743
104ERN10.70399790
105ERBB30.69879349
106STK100.69214907
107CDK190.68619323
108BMPR1B0.67158998
109PAK30.66836676
110MYLK0.66078796
111STK160.65813025
112PAK40.63279956
113IRAK40.63257582
114LCK0.61873905
115LYN0.61723318
116PKN20.60978696
117WNK40.60162177
118MAP2K20.59940788
119OBSCN0.59671673
120FRK0.57201077
121ADRBK10.56816489
122CAMK10.56447718
123RAF10.55366110
124FER0.55118017
125NTRK10.54917752
126YES10.54831476
127PIK3CG0.53915681
128DAPK10.53448082
129MAP3K140.52632995
130CCNB10.51931634
131STK40.51452839
132PIM10.50993878
133EIF2AK20.50041017
134CDK80.48523041
135BRD40.48400559
136PINK10.47752765
137HCK0.47020582
138MAP3K70.46186541
139FGFR10.46150516
140DYRK30.44863691
141MAP3K30.44448005
142CHUK0.44221132
143KDR0.43400202
144MAPK40.42221582
145CHEK10.41299293
146FGFR20.40725607
147IRAK30.40236765
148LMTK20.39947834
149STK240.39909609
150ITK0.39111765
151CSNK1A10.38625073
152MARK30.38453409
153AKT30.37987635
154MAPK130.37724167
155CSNK1E0.37198272
156PRKCG0.37174074
157EGFR0.36996539
158PRKCI0.36930800
159TNK20.36727167
160MELK0.36233641
161CDK30.36003975
162PRKAA20.35595773
163PIK3CA0.35588511
164STK390.35537248
165CSNK1D0.34975532
166CDK10.34379369
167JAK20.33482855
168PRKDC0.33376602
169ERBB20.32852097
170MST40.32590091
171IRAK10.32584980
172MAP2K70.31464892
173GRK50.31132521
174DMPK0.30519521
175DYRK1A0.30172927
176MAPK30.29466720
177MAP3K110.29132832
178MAPKAPK20.28882701
179VRK10.28827420
180MAPK110.28042423
181MARK20.27967417

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.42100953
2Propanoate metabolism_Homo sapiens_hsa006402.44966314
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.44663841
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.37196222
5RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.35372361
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32379724
7Ribosome_Homo sapiens_hsa030102.28910048
8Leishmaniasis_Homo sapiens_hsa051402.24063673
9Platelet activation_Homo sapiens_hsa046112.16111080
10Cysteine and methionine metabolism_Homo sapiens_hsa002702.14821781
11Thyroid cancer_Homo sapiens_hsa052162.13139494
12Caffeine metabolism_Homo sapiens_hsa002322.11504342
13SNARE interactions in vesicular transport_Homo sapiens_hsa041302.09194127
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08427403
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02373861
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.96645202
17Hematopoietic cell lineage_Homo sapiens_hsa046401.96635500
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.96081073
19Homologous recombination_Homo sapiens_hsa034401.95235861
20Acute myeloid leukemia_Homo sapiens_hsa052211.93758977
21Steroid biosynthesis_Homo sapiens_hsa001001.90450286
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.88102727
23Fanconi anemia pathway_Homo sapiens_hsa034601.87314401
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.86639431
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.84460383
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83291140
27Basal transcription factors_Homo sapiens_hsa030221.81053373
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79160105
29Folate biosynthesis_Homo sapiens_hsa007901.74249770
30Proteasome_Homo sapiens_hsa030501.71376279
31Shigellosis_Homo sapiens_hsa051311.70325819
32* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69116198
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68383640
34RNA polymerase_Homo sapiens_hsa030201.61983647
35Butanoate metabolism_Homo sapiens_hsa006501.59812787
36B cell receptor signaling pathway_Homo sapiens_hsa046621.59017185
37Tryptophan metabolism_Homo sapiens_hsa003801.58208585
38Pertussis_Homo sapiens_hsa051331.57569657
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.55609302
40African trypanosomiasis_Homo sapiens_hsa051431.52179171
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52169540
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51906331
43RNA transport_Homo sapiens_hsa030131.47002946
44Mismatch repair_Homo sapiens_hsa034301.42373553
45Other glycan degradation_Homo sapiens_hsa005111.42237890
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41222105
47RNA degradation_Homo sapiens_hsa030181.37015662
48Legionellosis_Homo sapiens_hsa051341.36952938
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36383058
50Prolactin signaling pathway_Homo sapiens_hsa049171.34920538
51Pyruvate metabolism_Homo sapiens_hsa006201.28610359
52beta-Alanine metabolism_Homo sapiens_hsa004101.28207335
53Fatty acid elongation_Homo sapiens_hsa000621.28137755
54DNA replication_Homo sapiens_hsa030301.28096629
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.27517671
56Retinol metabolism_Homo sapiens_hsa008301.26237648
57Nitrogen metabolism_Homo sapiens_hsa009101.25477662
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25065625
59Cell cycle_Homo sapiens_hsa041101.24709970
60Osteoclast differentiation_Homo sapiens_hsa043801.24435200
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22639904
62ABC transporters_Homo sapiens_hsa020101.22491718
63TNF signaling pathway_Homo sapiens_hsa046681.19191879
64Measles_Homo sapiens_hsa051621.18783868
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17213252
66Nucleotide excision repair_Homo sapiens_hsa034201.16900239
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16313084
68Fatty acid metabolism_Homo sapiens_hsa012121.14467726
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14434926
70Spliceosome_Homo sapiens_hsa030401.13957986
71Phototransduction_Homo sapiens_hsa047441.13066632
72Primary immunodeficiency_Homo sapiens_hsa053401.12469033
73One carbon pool by folate_Homo sapiens_hsa006701.12215566
74NOD-like receptor signaling pathway_Homo sapiens_hsa046211.10206584
75Toxoplasmosis_Homo sapiens_hsa051451.08448192
76Intestinal immune network for IgA production_Homo sapiens_hsa046721.08345655
77Drug metabolism - other enzymes_Homo sapiens_hsa009831.08328752
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07735401
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06155929
80Steroid hormone biosynthesis_Homo sapiens_hsa001401.05728569
81Herpes simplex infection_Homo sapiens_hsa051681.05710453
82Ether lipid metabolism_Homo sapiens_hsa005651.05543661
83Linoleic acid metabolism_Homo sapiens_hsa005911.04741043
84Salmonella infection_Homo sapiens_hsa051321.04350309
85Influenza A_Homo sapiens_hsa051641.04085151
86N-Glycan biosynthesis_Homo sapiens_hsa005101.03294013
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03169699
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01609811
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00777484
90alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00570252
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98505850
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96775113
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.95359962
94p53 signaling pathway_Homo sapiens_hsa041150.95276270
95Glutathione metabolism_Homo sapiens_hsa004800.93139076
96Hepatitis C_Homo sapiens_hsa051600.93048382
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.92972869
98Lysine degradation_Homo sapiens_hsa003100.92584833
99Fat digestion and absorption_Homo sapiens_hsa049750.91721294
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.89682746
101mRNA surveillance pathway_Homo sapiens_hsa030150.87217526
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86800164
103Purine metabolism_Homo sapiens_hsa002300.86044283
104Malaria_Homo sapiens_hsa051440.85702782
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85687111
106Tuberculosis_Homo sapiens_hsa051520.85173911
107Olfactory transduction_Homo sapiens_hsa047400.84174513
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83437114
109Hepatitis B_Homo sapiens_hsa051610.83035955
110Antigen processing and presentation_Homo sapiens_hsa046120.81582709
111Base excision repair_Homo sapiens_hsa034100.81322822
1122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79762379
113Regulation of autophagy_Homo sapiens_hsa041400.77759068
114Arginine biosynthesis_Homo sapiens_hsa002200.77529068
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76998319
116Biosynthesis of amino acids_Homo sapiens_hsa012300.75926902
117* Metabolic pathways_Homo sapiens_hsa011000.75429593
118Carbon metabolism_Homo sapiens_hsa012000.74057533
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73603107
120Hippo signaling pathway_Homo sapiens_hsa043900.73294244
121Huntingtons disease_Homo sapiens_hsa050160.71897998
122Peroxisome_Homo sapiens_hsa041460.71820668
123Chronic myeloid leukemia_Homo sapiens_hsa052200.70871955
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70050994
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69736709
126Pyrimidine metabolism_Homo sapiens_hsa002400.69512639
127Histidine metabolism_Homo sapiens_hsa003400.68877441
128Oxidative phosphorylation_Homo sapiens_hsa001900.67649701
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.67064016
130Tight junction_Homo sapiens_hsa045300.66017521
131Complement and coagulation cascades_Homo sapiens_hsa046100.63939793
132Starch and sucrose metabolism_Homo sapiens_hsa005000.63130372
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62067725
134Arginine and proline metabolism_Homo sapiens_hsa003300.60848474
135Galactose metabolism_Homo sapiens_hsa000520.60790087
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60659576
137Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60565241
138VEGF signaling pathway_Homo sapiens_hsa043700.60050154
139Adherens junction_Homo sapiens_hsa045200.59539910
140Apoptosis_Homo sapiens_hsa042100.58551551
141Insulin resistance_Homo sapiens_hsa049310.57586802
142Chemokine signaling pathway_Homo sapiens_hsa040620.57407235
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56111102
144Parkinsons disease_Homo sapiens_hsa050120.53192838
145Vitamin B6 metabolism_Homo sapiens_hsa007500.52579692
146Arachidonic acid metabolism_Homo sapiens_hsa005900.52127214
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49634578
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48219568
149Oocyte meiosis_Homo sapiens_hsa041140.48160204
150Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48117750
151Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47674803
152Mineral absorption_Homo sapiens_hsa049780.47422762
153Nicotine addiction_Homo sapiens_hsa050330.45581967
154TGF-beta signaling pathway_Homo sapiens_hsa043500.44947256
155Tyrosine metabolism_Homo sapiens_hsa003500.44410392
156Circadian rhythm_Homo sapiens_hsa047100.43697011
157Central carbon metabolism in cancer_Homo sapiens_hsa052300.43072491
158Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.42464033
159Pancreatic cancer_Homo sapiens_hsa052120.41880681
160Taste transduction_Homo sapiens_hsa047420.40793057
161Selenocompound metabolism_Homo sapiens_hsa004500.40786056
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.39823596
163Rap1 signaling pathway_Homo sapiens_hsa040150.39576165
164Vitamin digestion and absorption_Homo sapiens_hsa049770.36549313
165Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36110807
166Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35597564
167Allograft rejection_Homo sapiens_hsa053300.35299224
168Protein export_Homo sapiens_hsa030600.35116387
169Fatty acid degradation_Homo sapiens_hsa000710.32515628
170Inositol phosphate metabolism_Homo sapiens_hsa005620.32213140
171Rheumatoid arthritis_Homo sapiens_hsa053230.31789833
172Chemical carcinogenesis_Homo sapiens_hsa052040.31775709
173Sphingolipid metabolism_Homo sapiens_hsa006000.31671651
174Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31276320

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