GCNT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family. It is essential to the formation of Gal beta 1-3(GlcNAc beta 1-6)GalNAc structures and the core 2 O-glycan branch. The gene coding this enzyme was originally mapped to 9q21, but was later localized to 9q13. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1urate metabolic process (GO:0046415)7.63896064
2aminoglycoside antibiotic metabolic process (GO:0030647)7.49389236
3drug transmembrane transport (GO:0006855)6.62941650
4drug transport (GO:0015893)6.04620781
5toxin transport (GO:1901998)6.03002661
6organic cation transport (GO:0015695)5.97907917
7angiotensin maturation (GO:0002003)5.62678352
8lysine catabolic process (GO:0006554)5.48389701
9lysine metabolic process (GO:0006553)5.48389701
10sequestering of extracellular ligand from receptor (GO:0035581)5.08201352
11phosphate ion transport (GO:0006817)4.81519793
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.73123953
13glycoside metabolic process (GO:0016137)4.57000643
14nodal signaling pathway (GO:0038092)4.54500486
15UDP-N-acetylglucosamine metabolic process (GO:0006047)4.45032866
16L-ascorbic acid metabolic process (GO:0019852)4.42866354
17peptide hormone processing (GO:0016486)4.42300266
18vitamin D metabolic process (GO:0042359)4.38486542
19renal absorption (GO:0070293)4.33567209
20phosphate ion transmembrane transport (GO:0035435)4.18709752
21regulation of transforming growth factor beta1 production (GO:0032908)4.17122607
22excretion (GO:0007588)4.14693964
23regulation of interferon-beta biosynthetic process (GO:0045357)4.08985054
24peptide catabolic process (GO:0043171)4.06443098
25auditory receptor cell differentiation (GO:0042491)4.05952808
26bundle of His cell to Purkinje myocyte communication (GO:0086069)3.96399505
27quaternary ammonium group transport (GO:0015697)3.92508614
28response to thyroid hormone (GO:0097066)3.90251201
29cysteine metabolic process (GO:0006534)3.88385369
30valine metabolic process (GO:0006573)3.83318427
31signal transduction involved in regulation of gene expression (GO:0023019)3.81509370
32oligosaccharide catabolic process (GO:0009313)3.77834184
33regulation of type B pancreatic cell apoptotic process (GO:2000674)3.75021809
34response to mercury ion (GO:0046689)3.70138957
35COPII vesicle coating (GO:0048208)3.66472231
36transcytosis (GO:0045056)3.63187603
37sphingomyelin metabolic process (GO:0006684)3.62350925
38intestinal absorption (GO:0050892)3.58993751
39negative regulation of keratinocyte proliferation (GO:0010839)3.54985653
40tricarboxylic acid metabolic process (GO:0072350)3.50898636
41intestinal epithelial cell development (GO:0060576)3.49671332
42endocrine pancreas development (GO:0031018)3.44526746
43modified amino acid transport (GO:0072337)3.41328767
44water-soluble vitamin biosynthetic process (GO:0042364)3.39443697
45thyroid hormone metabolic process (GO:0042403)3.34755889
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34629668
47positive regulation by organism of defense response of other organism involved in symbiotic interact3.34629668
48modulation by symbiont of host immune response (GO:0052553)3.34629668
49positive regulation by symbiont of host defense response (GO:0052509)3.34629668
50modulation by symbiont of host defense response (GO:0052031)3.34629668
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34629668
52epoxygenase P450 pathway (GO:0019373)3.34109833
53early endosome to late endosome transport (GO:0045022)3.30044428
54regulation of protein glycosylation (GO:0060049)3.29834878
55extracellular negative regulation of signal transduction (GO:1900116)3.27641774
56extracellular regulation of signal transduction (GO:1900115)3.27641774
57positive regulation of glycoprotein biosynthetic process (GO:0010560)3.27486121
58neutrophil activation involved in immune response (GO:0002283)3.22845884
59negative regulation of B cell proliferation (GO:0030889)3.17110249
60nonribosomal peptide biosynthetic process (GO:0019184)3.16053549
61glandular epithelial cell differentiation (GO:0002067)3.13743537
62phosphate ion homeostasis (GO:0055062)3.13385800
63trivalent inorganic anion homeostasis (GO:0072506)3.13385800
64keratan sulfate catabolic process (GO:0042340)3.12762018
65cellular response to vitamin D (GO:0071305)3.10047447
66signal peptide processing (GO:0006465)3.09817574
67lactate metabolic process (GO:0006089)3.09056828
68regulation of interferon-alpha production (GO:0032647)3.08793565
69* O-glycan processing (GO:0016266)3.08504238
70metanephric nephron epithelium development (GO:0072243)3.07267139
71definitive hemopoiesis (GO:0060216)3.06649373
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06281611
73branched-chain amino acid metabolic process (GO:0009081)3.05874753
74metanephric tubule development (GO:0072170)3.04812118
75metanephric nephron tubule development (GO:0072234)3.04812118
76drug catabolic process (GO:0042737)3.04021710
77positive regulation of glycolytic process (GO:0045821)3.03612049
78regulation of mesoderm development (GO:2000380)3.03134728
79eosinophil chemotaxis (GO:0048245)3.01787362
80positive regulation of B cell differentiation (GO:0045579)3.00087025
81L-alpha-amino acid transmembrane transport (GO:1902475)2.99723239
82hepatocyte apoptotic process (GO:0097284)2.98160553
83pyrimidine ribonucleoside catabolic process (GO:0046133)2.97098516
84positive regulation of interferon-alpha production (GO:0032727)2.96657689
85carnitine metabolic process (GO:0009437)2.95582228
86regulation of B cell receptor signaling pathway (GO:0050855)2.92876563
87negative regulation of execution phase of apoptosis (GO:1900118)2.89490786
88carnitine transport (GO:0015879)2.86137657
89amino-acid betaine transport (GO:0015838)2.86137657
90negative regulation of granulocyte differentiation (GO:0030853)2.86061075
91regulation of extracellular matrix disassembly (GO:0010715)2.82791970
92eosinophil migration (GO:0072677)2.82144513
93seminiferous tubule development (GO:0072520)2.80368763
94glucuronate metabolic process (GO:0019585)2.80289938
95uronic acid metabolic process (GO:0006063)2.80289938
96insulin secretion (GO:0030073)2.78776237
97magnesium ion transport (GO:0015693)2.78219277
98desmosome organization (GO:0002934)2.76861598
99regulation of guanylate cyclase activity (GO:0031282)2.76374288
100immunoglobulin mediated immune response (GO:0016064)2.76010258
101positive regulation of protein autophosphorylation (GO:0031954)2.75994869
102macrophage activation involved in immune response (GO:0002281)2.75702147
103regulation of keratinocyte proliferation (GO:0010837)2.75584576
104cellular extravasation (GO:0045123)2.75076043
105metanephric epithelium development (GO:0072207)2.73966589
106aspartate family amino acid catabolic process (GO:0009068)2.73523344
107pinocytosis (GO:0006907)2.73350666
108positive regulation of glycoprotein metabolic process (GO:1903020)2.72710260
109exogenous drug catabolic process (GO:0042738)2.72657570
110homocysteine metabolic process (GO:0050667)2.72530349
111cytidine metabolic process (GO:0046087)2.71691224
112cytidine catabolic process (GO:0006216)2.71691224
113cytidine deamination (GO:0009972)2.71691224
114negative regulation of activin receptor signaling pathway (GO:0032926)2.71384316
115L-fucose catabolic process (GO:0042355)2.70010351
116fucose catabolic process (GO:0019317)2.70010351
117L-fucose metabolic process (GO:0042354)2.70010351
118positive regulation of histone H3-K4 methylation (GO:0051571)2.67351388
1192-oxoglutarate metabolic process (GO:0006103)2.66599417
120histamine transport (GO:0051608)2.66443678
121glyoxylate metabolic process (GO:0046487)2.66235742
122thyroid hormone generation (GO:0006590)2.65552403
123neutrophil activation (GO:0042119)2.65482626
124sphingolipid catabolic process (GO:0030149)2.64023634
125Golgi to endosome transport (GO:0006895)2.63497097
126respiratory burst (GO:0045730)2.63177160
127positive regulation of chemokine secretion (GO:0090197)2.62572081
128response to growth hormone (GO:0060416)2.61793473
129zinc ion transport (GO:0006829)2.60630526
130glycosphingolipid catabolic process (GO:0046479)2.60542733
131digestion (GO:0007586)2.60332970
132beta-amyloid metabolic process (GO:0050435)2.60239955
133positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.59915368
134amino-acid betaine metabolic process (GO:0006577)2.59096083
135adhesion of symbiont to host cell (GO:0044650)2.58711776
136virion attachment to host cell (GO:0019062)2.58711776
137glutathione biosynthetic process (GO:0006750)2.57540401
138regulation of glucokinase activity (GO:0033131)2.56231700
139regulation of hexokinase activity (GO:1903299)2.56231700
140negative regulation of hormone metabolic process (GO:0032351)2.56228212
141membrane lipid catabolic process (GO:0046466)2.56208213
142cobalamin metabolic process (GO:0009235)2.56020712
143negative regulation of phagocytosis (GO:0050765)2.55920663
144fructose metabolic process (GO:0006000)2.55821529
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54491564
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54491564
147antigen processing and presentation of endogenous antigen (GO:0019883)2.54209995
148negative regulation of hormone biosynthetic process (GO:0032353)2.53921838
149cellular response to thyroid hormone stimulus (GO:0097067)2.53767092
150bone resorption (GO:0045453)2.53681327
151lipoprotein transport (GO:0042953)2.52318466
152nucleotide transmembrane transport (GO:1901679)2.52306988
153response to phenylpropanoid (GO:0080184)2.52188170
154superoxide anion generation (GO:0042554)2.52075282
155* protein O-linked glycosylation (GO:0006493)2.51608778
156regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.51276522
157fucose metabolic process (GO:0006004)2.51052635
158granulocyte activation (GO:0036230)2.50922730
159vitamin biosynthetic process (GO:0009110)2.50570168
160positive regulation of gamma-delta T cell activation (GO:0046645)2.50075932
161parental behavior (GO:0060746)2.49743580
162phospholipid scrambling (GO:0017121)2.49463485
163protoporphyrinogen IX metabolic process (GO:0046501)2.49306430
164regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.48959824
165cellular response to zinc ion (GO:0071294)2.48882474
166response to peptidoglycan (GO:0032494)2.48829751
167regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.48524567
168primitive streak formation (GO:0090009)2.48198611
169phospholipid dephosphorylation (GO:0046839)2.48142119
170regulation of chemokine secretion (GO:0090196)2.46518782
171surfactant homeostasis (GO:0043129)2.45986570
172photoreceptor cell maintenance (GO:0045494)2.44479228
173tryptophan metabolic process (GO:0006568)2.44270419
174indole-containing compound catabolic process (GO:0042436)2.44084433
175indolalkylamine catabolic process (GO:0046218)2.44084433
176tryptophan catabolic process (GO:0006569)2.44084433
177epithelial cell fate commitment (GO:0072148)2.43793149
178somite rostral/caudal axis specification (GO:0032525)2.43115756
179sulfur compound transport (GO:0072348)2.43104748
180regulation of B cell differentiation (GO:0045577)2.41682157
181vitamin transport (GO:0051180)2.41248609
182fatty acid beta-oxidation (GO:0006635)2.40169227
183mRNA modification (GO:0016556)2.38615112
184polyol catabolic process (GO:0046174)2.38395759
185glycolipid catabolic process (GO:0019377)2.38064693
186ceramide catabolic process (GO:0046514)2.37523594
187nucleotide-sugar metabolic process (GO:0009225)2.37126290
188cellular glucuronidation (GO:0052695)2.36113364
189establishment of protein localization to Golgi (GO:0072600)2.35258503
190positive regulation of insulin secretion (GO:0032024)2.34961560
191negative regulation of complement activation (GO:0045916)2.34025903
192glycosylceramide metabolic process (GO:0006677)2.33683502
193zinc ion transmembrane transport (GO:0071577)2.33326882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.23998835
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.89937937
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.56369420
4E2F7_22180533_ChIP-Seq_HELA_Human3.39588403
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.32679652
6SCL_19346495_ChIP-Seq_HPC-7_Human3.24082522
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.05196845
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.03361178
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90612933
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.89607913
11GATA1_22025678_ChIP-Seq_K562_Human2.81913424
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.81704313
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60535777
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.55943649
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.49568250
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.43871428
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43044986
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.41393658
19* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35699810
20* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31256386
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.25384118
22SALL1_21062744_ChIP-ChIP_HESCs_Human2.24080367
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.23586402
24PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19853255
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14327029
26AR_21909140_ChIP-Seq_LNCAP_Human2.06193803
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05077242
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03800109
29ESR1_21235772_ChIP-Seq_MCF-7_Human2.03585949
30SPI1_23547873_ChIP-Seq_NB4_Human2.02410895
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98763258
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.98656280
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.98192914
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97140603
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.96632176
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.95231090
37* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.93842381
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.90555825
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.89607670
40CDX2_22108803_ChIP-Seq_LS180_Human1.89480574
41* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88022057
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85397433
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.85075417
44VDR_21846776_ChIP-Seq_THP-1_Human1.82821437
45MYB_26560356_Chip-Seq_TH2_Human1.80910998
46* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76089532
47MYB_26560356_Chip-Seq_TH1_Human1.75765866
48ZNF274_21170338_ChIP-Seq_K562_Hela1.74711698
49MAF_26560356_Chip-Seq_TH1_Human1.73571079
50MYC_22102868_ChIP-Seq_BL_Human1.73314838
51* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.71761742
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68564658
53SOX2_20726797_ChIP-Seq_SW620_Human1.68267539
54* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66877704
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65122818
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.64770284
57FUS_26573619_Chip-Seq_HEK293_Human1.64757802
58* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63086254
59P300_19829295_ChIP-Seq_ESCs_Human1.61799110
60VDR_24763502_ChIP-Seq_THP-1_Human1.59006620
61AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.57673643
62* SMAD3_21741376_ChIP-Seq_HESCs_Human1.55845147
63RUNX_20019798_ChIP-Seq_JUKART_Human1.55123270
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.54080087
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52933550
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52822121
67* PU_27001747_Chip-Seq_BMDM_Mouse1.50097461
68* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48061939
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48048150
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47539377
71CJUN_26792858_Chip-Seq_BT549_Human1.46685328
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.46369974
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.45825075
74* GATA1_19941827_ChIP-Seq_MEL_Mouse1.45271273
75* BRD4_25478319_ChIP-Seq_HGPS_Human1.44502683
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43169607
77TCF7_22412390_ChIP-Seq_EML_Mouse1.43130284
78* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.41988586
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.41022274
80GATA1_19941826_ChIP-Seq_K562_Human1.40677177
81* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40216296
82* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40216296
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.38621294
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.37921333
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36321846
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35458975
87GATA2_19941826_ChIP-Seq_K562_Human1.34865141
88SPI1_23127762_ChIP-Seq_K562_Human1.33909937
89EWS_26573619_Chip-Seq_HEK293_Human1.33820512
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33485065
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33371848
92TP63_23658742_ChIP-Seq_EP156T_Human1.33134947
93BCAT_22108803_ChIP-Seq_LS180_Human1.32955654
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30649472
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28928485
96* FOXA1_25552417_ChIP-Seq_VCAP_Human1.28854509
97FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.27339527
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.27296441
99UTX_26944678_Chip-Seq_JUKART_Human1.26815928
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26688095
101ER_23166858_ChIP-Seq_MCF-7_Human1.26610086
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26358816
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.26192811
104* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.26192493
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25888127
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23568983
107CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23103230
108* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22933156
109TCF4_22108803_ChIP-Seq_LS180_Human1.21815021
110TFEB_21752829_ChIP-Seq_HELA_Human1.21046518
111* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20970066
112GATA3_26560356_Chip-Seq_TH2_Human1.20949246
113STAT3_23295773_ChIP-Seq_U87_Human1.19985643
114TAF15_26573619_Chip-Seq_HEK293_Human1.19469937
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19173503
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18555824
117CMYC_18555785_Chip-Seq_ESCs_Mouse1.18225639
118AR_20517297_ChIP-Seq_VCAP_Human1.17881798
119VDR_24787735_ChIP-Seq_THP-1_Human1.17035985
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17013137
121SMAD4_21799915_ChIP-Seq_A2780_Human1.16735708
122HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16251939
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16179166
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.15684534
125* SOX2_19829295_ChIP-Seq_ESCs_Human1.15471127
126* NANOG_19829295_ChIP-Seq_ESCs_Human1.15471127
127ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15442974
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.15108359
129* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14039143
130PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13564813
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12375432
132GATA3_27048872_Chip-Seq_THYMUS_Human1.12099202
133SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12039466
134FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11996920
135FOXA1_25329375_ChIP-Seq_VCAP_Human1.11996920
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11173806
137TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10569322
138* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09779464
139* GATA4_25053715_ChIP-Seq_YYC3_Human1.09713063
140* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09597179
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09436764
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09327104
143E2F1_18555785_Chip-Seq_ESCs_Mouse1.08897511
144* GATA6_25053715_ChIP-Seq_YYC3_Human1.08687043
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.08544662
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08267838
147AR_25329375_ChIP-Seq_VCAP_Human1.07774682
148* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07681967
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.07388584
150P53_22387025_ChIP-Seq_ESCs_Mouse1.06224593
151GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.05479627
152AHR_22903824_ChIP-Seq_MCF-7_Human1.04713571
153* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04435039
154RXR_22158963_ChIP-Seq_LIVER_Mouse1.03935742
155PRDM14_20953172_ChIP-Seq_ESCs_Human1.03873703
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03068838
157CDX2_20551321_ChIP-Seq_CACO-2_Human1.02905125
158* EP300_21415370_ChIP-Seq_HL-1_Mouse1.01822155
159HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01025134
160TCF4_18268006_ChIP-ChIP_LS174T_Human1.00857642
161P300_18555785_Chip-Seq_ESCs_Mouse1.00832450
162* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00118257
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.99614488
164CLOCK_20551151_ChIP-Seq_293T_Human0.99563159
165KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98845546
166GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96963070
167SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96943858
168CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96773797
169ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96675955
170TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95979034
171* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94463635
172FOXO3_23340844_ChIP-Seq_DLD1_Human0.93911346
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93355825
174ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92727242
175RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90335810
176ELK3_25401928_ChIP-Seq_HUVEC_Human0.89829498
177* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85880883
178LXR_22158963_ChIP-Seq_LIVER_Mouse0.85629051
179CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85347775
180* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.85241124
181SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84473874
182* NCOR1_26117541_ChIP-Seq_K562_Human0.83976769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.73540207
2MP0010234_abnormal_vibrissa_follicle3.71107370
3MP0004043_abnormal_pH_regulation3.41822678
4MP0005058_abnormal_lysosome_morphology2.92745823
5MP0010352_gastrointestinal_tract_polyps2.83239588
6MP0003300_gastrointestinal_ulcer2.82879932
7MP0004019_abnormal_vitamin_homeostasis2.76922791
8MP0001666_abnormal_nutrient_absorption2.68461908
9MP0009643_abnormal_urine_homeostasis2.64898012
10MP0005085_abnormal_gallbladder_physiolo2.63485993
11MP0001835_abnormal_antigen_presentation2.59774516
12MP0008004_abnormal_stomach_pH2.59307642
13MP0000013_abnormal_adipose_tissue2.55862745
14MP0005332_abnormal_amino_acid2.54235810
15MP0002138_abnormal_hepatobiliary_system2.49866588
16MP0003195_calcinosis2.42088656
17MP0003890_abnormal_embryonic-extraembry2.40751953
18MP0002136_abnormal_kidney_physiology2.38639036
19MP0001765_abnormal_ion_homeostasis2.30251951
20MP0009780_abnormal_chondrocyte_physiolo2.23266135
21MP0001756_abnormal_urination2.21705259
22MP0003183_abnormal_peptide_metabolism2.12926711
23MP0003436_decreased_susceptibility_to2.11999010
24MP0004147_increased_porphyrin_level2.08784623
25MP0005379_endocrine/exocrine_gland_phen2.07479464
26MP0006082_CNS_inflammation2.02925819
27MP0002909_abnormal_adrenal_gland2.00881289
28MP0002396_abnormal_hematopoietic_system1.99676452
29MP0003191_abnormal_cellular_cholesterol1.97614112
30MP0002876_abnormal_thyroid_physiology1.97237758
31MP0005636_abnormal_mineral_homeostasis1.95417534
32MP0003283_abnormal_digestive_organ1.91594139
33MP0003172_abnormal_lysosome_physiology1.88166780
34MP0005377_hearing/vestibular/ear_phenot1.78722655
35MP0003878_abnormal_ear_physiology1.78722655
36MP0005464_abnormal_platelet_physiology1.78347428
37MP0001958_emphysema1.78061529
38MP0005671_abnormal_response_to1.76949715
39MP0004264_abnormal_extraembryonic_tissu1.76007360
40MP0008438_abnormal_cutaneous_collagen1.73048915
41MP0002837_dystrophic_cardiac_calcinosis1.72650237
42MP0010678_abnormal_skin_adnexa1.72379787
43MP0003303_peritoneal_inflammation1.69896317
44MP0003787_abnormal_imprinting1.68156718
45MP0005367_renal/urinary_system_phenotyp1.67727484
46MP0000516_abnormal_urinary_system1.67727484
47MP0002419_abnormal_innate_immunity1.67371206
48MP0003186_abnormal_redox_activity1.66645821
49MP0002693_abnormal_pancreas_physiology1.64858941
50MP0002928_abnormal_bile_duct1.62179717
51MP0003656_abnormal_erythrocyte_physiolo1.61318984
52MP0001873_stomach_inflammation1.60465472
53MP0005000_abnormal_immune_tolerance1.58832767
54MP0002452_abnormal_antigen_presenting1.56451832
55MP0008877_abnormal_DNA_methylation1.54487037
56MP0005310_abnormal_salivary_gland1.50540227
57MP0000465_gastrointestinal_hemorrhage1.50242544
58MP0002148_abnormal_hypersensitivity_rea1.50168146
59MP0003566_abnormal_cell_adhesion1.46461467
60MP0001800_abnormal_humoral_immune1.45080029
61MP0000427_abnormal_hair_cycle1.44174840
62MP0010329_abnormal_lipoprotein_level1.42405692
63MP0005025_abnormal_response_to1.42297311
64MP0001853_heart_inflammation1.38469050
65MP0000490_abnormal_crypts_of1.36603192
66MP0003718_maternal_effect1.36480149
67* MP0001819_abnormal_immune_cell1.35976260
68MP0002723_abnormal_immune_serum1.35855743
69* MP0001845_abnormal_inflammatory_respons1.35653936
70* MP0002420_abnormal_adaptive_immunity1.35297183
71* MP0005387_immune_system_phenotype1.35068859
72* MP0001790_abnormal_immune_system1.35068859
73MP0005275_abnormal_skin_tensile1.32950459
74MP0000689_abnormal_spleen_morphology1.32448581
75MP0003950_abnormal_plasma_membrane1.32445508
76MP0008469_abnormal_protein_level1.30876123
77MP0001944_abnormal_pancreas_morphology1.30609274
78MP0005645_abnormal_hypothalamus_physiol1.30253571
79MP0000343_altered_response_to1.30169924
80MP0004133_heterotaxia1.30066964
81MP0003252_abnormal_bile_duct1.28134973
82MP0001664_abnormal_digestion1.27567329
83MP0000685_abnormal_immune_system1.27214213
84MP0001545_abnormal_hematopoietic_system1.26577751
85MP0005397_hematopoietic_system_phenotyp1.26577751
86MP0002163_abnormal_gland_morphology1.25425022
87MP0004808_abnormal_hematopoietic_stem1.24972102
88MP0001533_abnormal_skeleton_physiology1.23832190
89* MP0002398_abnormal_bone_marrow1.23245251
90MP0000462_abnormal_digestive_system1.22501997
91MP0010155_abnormal_intestine_physiology1.21239147
92MP0009785_altered_susceptibility_to1.20528273
93MP0009278_abnormal_bone_marrow1.20340124
94MP0002722_abnormal_immune_system1.18932423
95MP0002405_respiratory_system_inflammati1.18642774
96MP0003724_increased_susceptibility_to1.18457527
97MP0000383_abnormal_hair_follicle1.18076179
98MP0002933_joint_inflammation1.14052780
99* MP0000716_abnormal_immune_system1.13286702
100MP0008057_abnormal_DNA_replication1.13107195
101MP0002254_reproductive_system_inflammat1.12825943
102MP0002166_altered_tumor_susceptibility1.11700990
103* MP0002135_abnormal_kidney_morphology1.11139173
104MP0008875_abnormal_xenobiotic_pharmacok1.10737339
105* MP0002429_abnormal_blood_cell1.08517110
106MP0002998_abnormal_bone_remodeling1.08388061
107MP0009840_abnormal_foam_cell1.08181638
108MP0005220_abnormal_exocrine_pancreas1.07024942
109MP0009764_decreased_sensitivity_to1.06962206
110MP0005084_abnormal_gallbladder_morpholo1.06151822
111MP0003795_abnormal_bone_structure1.03812263
112MP0005319_abnormal_enzyme/_coenzyme1.03044760
113MP0010386_abnormal_urinary_bladder1.00835153
114MP0006054_spinal_hemorrhage1.00662002
115MP0002009_preneoplasia0.98486853
116* MP0000477_abnormal_intestine_morphology0.96674520
117MP0001663_abnormal_digestive_system0.96241647
118MP0009333_abnormal_splenocyte_physiolog0.95176567
119MP0010307_abnormal_tumor_latency0.94291044
120MP0000470_abnormal_stomach_morphology0.94173049
121MP0005395_other_phenotype0.93253974
122MP0000569_abnormal_digit_pigmentation0.91571903
123MP0002078_abnormal_glucose_homeostasis0.89153213
124MP0003866_abnormal_defecation0.87956291
125MP0008961_abnormal_basal_metabolism0.87198812
126MP0005584_abnormal_enzyme/coenzyme_acti0.86601188
127MP0000538_abnormal_urinary_bladder0.86052181
128MP0003806_abnormal_nucleotide_metabolis0.85457958
129MP0005166_decreased_susceptibility_to0.84869932
130MP0000015_abnormal_ear_pigmentation0.84664010
131MP0002139_abnormal_hepatobiliary_system0.83523620
132MP0002877_abnormal_melanocyte_morpholog0.83016684
133MP0004947_skin_inflammation0.82762933
134MP0000230_abnormal_systemic_arterial0.82499460
135MP0002938_white_spotting0.81792738
136MP0003448_altered_tumor_morphology0.81697207
137MP0000858_altered_metastatic_potential0.81538945
138MP0001764_abnormal_homeostasis0.81097737
139MP0003868_abnormal_feces_composition0.80651516
140MP0003075_altered_response_to0.79080789
141MP0003638_abnormal_response/metabolism_0.78996848
142MP0002118_abnormal_lipid_homeostasis0.78930540
143MP0005174_abnormal_tail_pigmentation0.78899210
144MP0003828_pulmonary_edema0.78886113
145MP0000371_diluted_coat_color0.78506564
146MP0001881_abnormal_mammary_gland0.77456376
147MP0002060_abnormal_skin_morphology0.77306807
148MP0005365_abnormal_bile_salt0.77194662
149MP0008872_abnormal_physiological_respon0.76232374
150MP0002006_tumorigenesis0.74869291
151MP0003943_abnormal_hepatobiliary_system0.73978544
152MP0000681_abnormal_thyroid_gland0.72720905
153MP0005381_digestive/alimentary_phenotyp0.72578805
154MP0002168_other_aberrant_phenotype0.71698423
155MP0002896_abnormal_bone_mineralization0.69375483
156MP0003763_abnormal_thymus_physiology0.69104386
157MP0005448_abnormal_energy_balance0.68377441
158MP0003045_fibrosis0.68138213
159MP0003693_abnormal_embryo_hatching0.68012339
160MP0000678_abnormal_parathyroid_gland0.65243760
161MP0003953_abnormal_hormone_level0.64149455

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)6.10792218
2Metabolic alkalosis (HP:0200114)6.02585999
3Hypokalemic alkalosis (HP:0001949)5.85505572
4Hypomagnesemia (HP:0002917)5.71904906
5Hyperactive renin-angiotensin system (HP:0000841)5.64273865
6Abnormality of chloride homeostasis (HP:0011422)5.34016663
7Polyuria (HP:0000103)5.24477184
8Abnormal urine output (HP:0012590)4.84837748
9Abnormality of magnesium homeostasis (HP:0004921)4.81189428
10Gout (HP:0001997)4.76434446
11Tetany (HP:0001281)4.71986327
12Abnormality of vitamin B metabolism (HP:0004340)4.63925829
13Abnormality of renal excretion (HP:0011036)4.60730727
14Proximal tubulopathy (HP:0000114)4.23781315
15Abnormal drinking behavior (HP:0030082)4.22579646
16Polydipsia (HP:0001959)4.22579646
17Chronic diarrhea (HP:0002028)4.10125457
18Vacuolated lymphocytes (HP:0001922)3.88659772
19Abnormality of the vitamin B12 metabolism (HP:0004341)3.73724277
20Abnormality of renin-angiotensin system (HP:0000847)3.71573252
21Hyperglycemia (HP:0003074)3.71266603
22Hematochezia (HP:0002573)3.67403509
23Hyperaldosteronism (HP:0000859)3.66779752
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.62047545
25Renal salt wasting (HP:0000127)3.60384428
26Increased purine levels (HP:0004368)3.59369517
27Hyperuricemia (HP:0002149)3.59369517
28Abnormality of vitamin metabolism (HP:0100508)3.52006699
29Hypoglycemic seizures (HP:0002173)3.49431284
30Renal tubular acidosis (HP:0001947)3.41315300
31Alkalosis (HP:0001948)3.37116745
32Congenital malformation of the right heart (HP:0011723)3.27982569
33Double outlet right ventricle (HP:0001719)3.27982569
34Hypercalciuria (HP:0002150)3.22452688
35Abnormal biliary tract morphology (HP:0012440)3.22134629
36Abnormality of purine metabolism (HP:0004352)3.19861900
37Metaphyseal cupping (HP:0003021)3.14473906
38Malnutrition (HP:0004395)3.11386695
39Hyperglycinuria (HP:0003108)3.08672572
40Delayed epiphyseal ossification (HP:0002663)3.08259882
41Abnormality of abdominal situs (HP:0011620)3.05760821
42Abdominal situs inversus (HP:0003363)3.05760821
43Symptomatic seizures (HP:0011145)2.93857236
44Generalized aminoaciduria (HP:0002909)2.92724868
45Hyperinsulinemic hypoglycemia (HP:0000825)2.89945640
46Recurrent abscess formation (HP:0002722)2.89528190
47IgM deficiency (HP:0002850)2.86498315
48Hydroxyprolinuria (HP:0003080)2.82818013
49Abnormality of proline metabolism (HP:0010907)2.82818013
50Abnormal tarsal ossification (HP:0008369)2.78566450
51Abnormality of the pancreatic islet cells (HP:0006476)2.74212608
52Abnormality of endocrine pancreas physiology (HP:0012093)2.74212608
53Hyperphosphatemia (HP:0002905)2.70753844
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.69726236
55Hypoglycemic coma (HP:0001325)2.67455517
56Bilateral sensorineural hearing impairment (HP:0008619)2.66533927
57Hypokalemia (HP:0002900)2.66487986
58Abnormal platelet function (HP:0011869)2.65087812
59Impaired platelet aggregation (HP:0003540)2.65087812
60Recurrent bacterial skin infections (HP:0005406)2.62011906
61Petechiae (HP:0000967)2.60356742
62Metaphyseal dysplasia (HP:0100255)2.52879236
63Increased cerebral lipofuscin (HP:0011813)2.51423106
64Abnormal pancreas size (HP:0012094)2.50879838
65Eczematoid dermatitis (HP:0000976)2.50838025
66Abnormality of macrophages (HP:0004311)2.49832268
67Epiphyseal dysplasia (HP:0002656)2.47385313
68Fat malabsorption (HP:0002630)2.43580657
69Intrahepatic cholestasis (HP:0001406)2.43176781
70Abnormal foot bone ossification (HP:0010675)2.36473729
71Hypothermia (HP:0002045)2.35287340
72Systemic lupus erythematosus (HP:0002725)2.33750751
73Abnormality of urine glucose concentration (HP:0011016)2.33749689
74Glycosuria (HP:0003076)2.33749689
75Dysostosis multiplex (HP:0000943)2.32881587
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.32860666
77Nephrocalcinosis (HP:0000121)2.32808837
78Right ventricular cardiomyopathy (HP:0011663)2.32523249
79Abnormal albumin level (HP:0012116)2.31928796
80Hypoalbuminemia (HP:0003073)2.31928796
81Metaphyseal irregularity (HP:0003025)2.31917684
82Abnormality of nucleobase metabolism (HP:0010932)2.29652495
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.28964319
84Abnormality of glycine metabolism (HP:0010895)2.24073983
85Abnormality of serine family amino acid metabolism (HP:0010894)2.24073983
86Mucopolysacchariduria (HP:0008155)2.24044508
87Urinary glycosaminoglycan excretion (HP:0003541)2.24044508
88Congenital sensorineural hearing impairment (HP:0008527)2.22032739
89Pathologic fracture (HP:0002756)2.21725983
90Flat acetabular roof (HP:0003180)2.21116533
91Increased CSF protein (HP:0002922)2.19460536
92Abnormality of the fingertips (HP:0001211)2.19044921
93Insulin-resistant diabetes mellitus (HP:0000831)2.18912941
94Decreased circulating renin level (HP:0003351)2.18300614
95Abnormality of potassium homeostasis (HP:0011042)2.17923727
96Biliary tract neoplasm (HP:0100574)2.17808474
97Myositis (HP:0100614)2.15966604
98Intestinal atresia (HP:0011100)2.15734251
99Autoimmune thrombocytopenia (HP:0001973)2.14340695
100Amelogenesis imperfecta (HP:0000705)2.13096753
101Ketoacidosis (HP:0001993)2.12935828
102Pancreatic islet-cell hyperplasia (HP:0004510)2.10026448
103Axonal loss (HP:0003447)2.09969107
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09561026
105Abnormality of polysaccharide metabolism (HP:0011012)2.09561026
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09561026
107Late onset (HP:0003584)2.08490037
108Tongue fasciculations (HP:0001308)2.08289410
109Disproportionate short-trunk short stature (HP:0003521)2.08274505
110Abnormality of fatty-acid metabolism (HP:0004359)2.06944348
111Hyponatremia (HP:0002902)2.06391138
112Vascular calcification (HP:0004934)2.02649725
113Nausea (HP:0002018)2.01887412
114Abnormality of calcium-phosphate metabolism (HP:0100530)1.99618404
115Tubular atrophy (HP:0000092)1.99209302
116Aqueductal stenosis (HP:0002410)1.98977902
117Methylmalonic aciduria (HP:0012120)1.96816287
118Hyperphosphaturia (HP:0003109)1.96064158
119Abnormality of sodium homeostasis (HP:0010931)1.95258152
120Chondrocalcinosis (HP:0000934)1.92909930
121Abnormality of carpal bone ossification (HP:0006257)1.92390477
122Testicular neoplasm (HP:0010788)1.92112979
123Abnormal glucose tolerance (HP:0001952)1.91428555
124Pancreatic fibrosis (HP:0100732)1.90425873
125Villous atrophy (HP:0011473)1.90422584
126Abnormality of small intestinal villus morphology (HP:0011472)1.90422584
127Methylmalonic acidemia (HP:0002912)1.89342428
128Dehydration (HP:0001944)1.87191730
129Protuberant abdomen (HP:0001538)1.87168191
130Hypophosphatemia (HP:0002148)1.86280845
131Confusion (HP:0001289)1.86204710
132Abnormal urine phosphate concentration (HP:0012599)1.85007131
133Abnormality of glycolipid metabolism (HP:0010969)1.84267328
134Abnormality of liposaccharide metabolism (HP:0010968)1.84267328
135Abnormality of glycosphingolipid metabolism (HP:0004343)1.84267328
136Orchitis (HP:0100796)1.84252312
137Enlarged penis (HP:0000040)1.82757732
138Palpitations (HP:0001962)1.81918416
139Enlarged kidneys (HP:0000105)1.80902491
140Nephrolithiasis (HP:0000787)1.79627572
141Pancreatic cysts (HP:0001737)1.79044528
142Renal tubular dysfunction (HP:0000124)1.77926306
143Optic neuritis (HP:0100653)1.77882011
144Retrobulbar optic neuritis (HP:0100654)1.77882011
145Progressive inability to walk (HP:0002505)1.77575588
146Abnormality of Sharpey fibers (HP:0100685)1.77433435
147Abnormality of the prostate (HP:0008775)1.77411735
148Albinism (HP:0001022)1.77247103
149Ketosis (HP:0001946)1.76278535
150Megaloblastic anemia (HP:0001889)1.75229337
151Stomatitis (HP:0010280)1.74932266
152Cardiovascular calcification (HP:0011915)1.73930718
153Cardiomegaly (HP:0001640)1.72848822
154Abdominal distention (HP:0003270)1.71960513
155Abnormal biliary tract physiology (HP:0012439)1.71681347
156Bile duct proliferation (HP:0001408)1.71681347
157Muscle fibrillation (HP:0010546)1.67118644
158Enlarged epiphyses (HP:0010580)1.66583856
159Encephalitis (HP:0002383)1.66426684
160Hypobetalipoproteinemia (HP:0003563)1.66371624
161Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65362234
162Thoracic kyphosis (HP:0002942)1.65235708
163Thin bony cortex (HP:0002753)1.64171176
164Persistence of primary teeth (HP:0006335)1.63547508
165Abnormality of the renal cortex (HP:0011035)1.62932807
166Autoimmune hemolytic anemia (HP:0001890)1.60832565
167Abnormality of the fetal cardiovascular system (HP:0010948)1.60022691
168Abnormal umbilical cord blood vessels (HP:0011403)1.60022691
169Single umbilical artery (HP:0001195)1.60022691
170Urethral obstruction (HP:0000796)1.58086508
171Steatorrhea (HP:0002570)1.57666248
172Thickened calvaria (HP:0002684)1.56934678
173Prominent supraorbital ridges (HP:0000336)1.56855784
174Abnormal rod and cone electroretinograms (HP:0008323)1.56763868
175Barrel-shaped chest (HP:0001552)1.55587792
176Prominent metopic ridge (HP:0005487)1.55153120
177Hypoplasia of the fovea (HP:0007750)1.54324078
178Aplasia/Hypoplasia of the fovea (HP:0008060)1.54324078
179Neoplasm of the rectum (HP:0100743)1.54134691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.19622652
2WNK35.90761965
3WNK44.76410175
4OXSR14.53190943
5TGFBR23.34427844
6BMPR1B2.72162441
7MAP4K12.12836672
8TXK2.12361436
9STK102.00106890
10TRIM281.94715601
11MAP2K31.93543768
12MAP3K31.87399344
13KIT1.84978313
14FGFR21.84055468
15MAP3K141.76916746
16GRK11.74484439
17MAP3K21.72532706
18NLK1.70454980
19DAPK21.58911461
20MST41.57753508
21CSF1R1.56475419
22AKT31.54221181
23TYK21.48842735
24BTK1.47994924
25TEC1.46740465
26IRAK41.45364491
27NME21.41669296
28STK391.33985033
29TBK11.33807185
30LRRK21.33677082
31NEK91.33278548
32EIF2AK11.31533481
33FER1.30609966
34PAK41.30506629
35EEF2K1.27975761
36PIK3CA1.26629884
37IRAK31.25738788
38PIM11.24443437
39MAP3K121.22307785
40STK38L1.21163999
41TRPM71.17436688
42SCYL21.16340471
43ZAP701.14530942
44MAP2K61.13244279
45ITK1.11754881
46CSNK1G11.09628088
47JAK31.09091942
48MYLK1.07459427
49TAOK31.04724262
50IKBKB1.02638224
51EPHB11.01210933
52MAPK151.00841464
53BCKDK1.00078414
54RPS6KA40.96218148
55PRKCE0.95994516
56STK40.95359540
57SGK30.94841951
58SYK0.92848189
59PAK30.91229972
60JAK10.89696531
61ADRBK20.88464510
62SGK20.88143434
63CDK60.87757966
64MATK0.86343938
65STK30.86315760
66PRKAA20.83696691
67JAK20.83301360
68LYN0.82095136
69RIPK40.81945322
70ERN10.81696232
71NEK10.81002392
72GRK70.80578120
73STK240.79782191
74MAP4K20.79368329
75RPS6KB20.78036473
76LATS10.77345143
77PKN20.75827807
78CSNK1G30.75525538
79MKNK20.74865846
80BLK0.74835387
81TNK20.74424755
82BRSK20.74351745
83WNK10.73144227
84PBK0.73082414
85GRK60.72115496
86INSRR0.68757195
87CAMK1D0.67982254
88HCK0.67632035
89YES10.66980593
90ERBB40.66754509
91PDK20.66370230
92SGK4940.66181960
93SGK2230.66181960
94IKBKE0.65535876
95LCK0.64365302
96CHUK0.64361559
97ERBB30.63525993
98PINK10.60845502
99CSK0.60027458
100CSNK1G20.58748236
101MARK30.58042051
102PIM20.57954339
103TAF10.56446022
104GSK3A0.55805142
105PTK60.54944534
106IRAK10.53933736
107MAP3K80.53819112
108MELK0.52388729
109CAMK1G0.51989881
110FLT30.51725360
111MAPKAPK30.50730319
112MAP3K60.50303815
113CDK120.50141379
114CAMK2D0.49745100
115MKNK10.49364927
116CDK40.49113336
117ZAK0.48339120
118PRKCD0.48241729
119PRKG20.48018612
120PLK30.47964023
121PLK20.47464230
122TSSK60.46797989
123ADRBK10.46578604
124MAPKAPK20.46400675
125PRKCI0.45338414
126MAPK110.44902713
127DYRK1B0.44865489
128MUSK0.44839083
129FGFR30.44647375
130EIF2AK30.44234273
131NEK20.43376252
132BMPR20.42616161
133PASK0.42336927
134CAMKK20.42317617
135MST1R0.42270427
136VRK10.42098327
137TGFBR10.41982975
138CSNK1A10.41967408
139TIE10.40839409
140NUAK10.38611993
141PNCK0.38520775
142HIPK20.38506135
143EPHA20.37754996
144FRK0.36654870
145PRKCQ0.36459435
146RPS6KA60.35568114
147ABL10.33500215
148TRIB30.32557033
149WEE10.31701709
150LMTK20.31469340
151PIK3CG0.30549917
152PLK40.27873553
153MAP2K10.26076281
154PRKCA0.25793339
155PAK20.24129287
156EGFR0.23296123
157BRD40.21818486

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.11272387
2Other glycan degradation_Homo sapiens_hsa005113.74757740
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.92175220
4Caffeine metabolism_Homo sapiens_hsa002322.85009240
5Fat digestion and absorption_Homo sapiens_hsa049752.53490661
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.52987528
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.32434579
8Lysosome_Homo sapiens_hsa041422.31271026
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.16095417
10Protein export_Homo sapiens_hsa030602.14485587
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.11274662
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02057948
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00609357
14Vitamin digestion and absorption_Homo sapiens_hsa049771.99575980
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89714044
16Propanoate metabolism_Homo sapiens_hsa006401.89569145
17Butanoate metabolism_Homo sapiens_hsa006501.87814367
18Collecting duct acid secretion_Homo sapiens_hsa049661.83278765
19Leishmaniasis_Homo sapiens_hsa051401.80796084
20Linoleic acid metabolism_Homo sapiens_hsa005911.76667668
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72778970
22Glutathione metabolism_Homo sapiens_hsa004801.69201015
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67833402
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63654481
25Protein digestion and absorption_Homo sapiens_hsa049741.60618139
26Ether lipid metabolism_Homo sapiens_hsa005651.56361906
27Peroxisome_Homo sapiens_hsa041461.54007826
28Renin-angiotensin system_Homo sapiens_hsa046141.52588415
29Type I diabetes mellitus_Homo sapiens_hsa049401.50916016
30Antigen processing and presentation_Homo sapiens_hsa046121.49615058
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.46491532
32Hematopoietic cell lineage_Homo sapiens_hsa046401.42864379
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42749108
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42237762
35Osteoclast differentiation_Homo sapiens_hsa043801.41278021
36Chemical carcinogenesis_Homo sapiens_hsa052041.37811895
37Retinol metabolism_Homo sapiens_hsa008301.33441085
38Lysine degradation_Homo sapiens_hsa003101.32678006
39Staphylococcus aureus infection_Homo sapiens_hsa051501.30744896
40beta-Alanine metabolism_Homo sapiens_hsa004101.28827449
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28279235
42B cell receptor signaling pathway_Homo sapiens_hsa046621.23716727
43Mineral absorption_Homo sapiens_hsa049781.23106740
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22128944
45Fatty acid degradation_Homo sapiens_hsa000711.21887958
46NF-kappa B signaling pathway_Homo sapiens_hsa040641.21204331
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.15474244
48Nitrogen metabolism_Homo sapiens_hsa009101.13958727
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12110110
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.11675765
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.11077172
52Tryptophan metabolism_Homo sapiens_hsa003801.10708593
53Tuberculosis_Homo sapiens_hsa051521.05299594
54Insulin secretion_Homo sapiens_hsa049111.04702287
55Steroid hormone biosynthesis_Homo sapiens_hsa001401.03447877
56Asthma_Homo sapiens_hsa053101.03095461
57Toxoplasmosis_Homo sapiens_hsa051451.01751374
58Legionellosis_Homo sapiens_hsa051341.01146359
59Pyruvate metabolism_Homo sapiens_hsa006201.00615474
60Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00126867
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98692990
62Starch and sucrose metabolism_Homo sapiens_hsa005000.96489465
63Measles_Homo sapiens_hsa051620.94188181
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93990520
65Vitamin B6 metabolism_Homo sapiens_hsa007500.93456452
66Phagosome_Homo sapiens_hsa041450.92543708
67Selenocompound metabolism_Homo sapiens_hsa004500.92412011
68Apoptosis_Homo sapiens_hsa042100.92201795
69Carbon metabolism_Homo sapiens_hsa012000.91380425
70Histidine metabolism_Homo sapiens_hsa003400.89601957
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.87944680
72N-Glycan biosynthesis_Homo sapiens_hsa005100.84594366
73Shigellosis_Homo sapiens_hsa051310.80856424
74Rheumatoid arthritis_Homo sapiens_hsa053230.78526809
75Fatty acid elongation_Homo sapiens_hsa000620.77426937
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77002414
77Sulfur metabolism_Homo sapiens_hsa009200.76558283
78Pancreatic secretion_Homo sapiens_hsa049720.74516002
79Malaria_Homo sapiens_hsa051440.74150070
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.73720094
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73705883
82Pertussis_Homo sapiens_hsa051330.73316138
83* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73062760
84Small cell lung cancer_Homo sapiens_hsa052220.71370131
85Influenza A_Homo sapiens_hsa051640.71198378
86Bile secretion_Homo sapiens_hsa049760.70804689
87Allograft rejection_Homo sapiens_hsa053300.69930436
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69255570
89Pancreatic cancer_Homo sapiens_hsa052120.69201007
90Pentose phosphate pathway_Homo sapiens_hsa000300.69016963
91Thyroid hormone synthesis_Homo sapiens_hsa049180.68896338
92Fructose and mannose metabolism_Homo sapiens_hsa000510.67955482
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67454701
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67260981
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66915871
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66443142
97TGF-beta signaling pathway_Homo sapiens_hsa043500.64318593
98Primary immunodeficiency_Homo sapiens_hsa053400.64242614
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63595488
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62107289
101Herpes simplex infection_Homo sapiens_hsa051680.61501161
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61392947
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.61300969
104Platelet activation_Homo sapiens_hsa046110.59401289
105Sphingolipid metabolism_Homo sapiens_hsa006000.58815838
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57233803
107Circadian rhythm_Homo sapiens_hsa047100.55682594
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55409855
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54665671
110Arginine and proline metabolism_Homo sapiens_hsa003300.54133793
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53634890
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53572587
113DNA replication_Homo sapiens_hsa030300.53556967
114Folate biosynthesis_Homo sapiens_hsa007900.51431649
115Hepatitis C_Homo sapiens_hsa051600.51063215
116ECM-receptor interaction_Homo sapiens_hsa045120.50189705
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50017911
118Arginine biosynthesis_Homo sapiens_hsa002200.49822241
119Hepatitis B_Homo sapiens_hsa051610.49726579
120One carbon pool by folate_Homo sapiens_hsa006700.48926519
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48675230
122PPAR signaling pathway_Homo sapiens_hsa033200.48537593
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48398285
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48345467
125Inositol phosphate metabolism_Homo sapiens_hsa005620.47841542
126Insulin resistance_Homo sapiens_hsa049310.47624118
127ABC transporters_Homo sapiens_hsa020100.47396844
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47360741
129* Metabolic pathways_Homo sapiens_hsa011000.47136840
130Chronic myeloid leukemia_Homo sapiens_hsa052200.46608768
131Galactose metabolism_Homo sapiens_hsa000520.46254046
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44834023
133Arachidonic acid metabolism_Homo sapiens_hsa005900.44245493
134Autoimmune thyroid disease_Homo sapiens_hsa053200.42766641
135Fatty acid metabolism_Homo sapiens_hsa012120.41100580
136Glycerolipid metabolism_Homo sapiens_hsa005610.40406939
137Glucagon signaling pathway_Homo sapiens_hsa049220.37818481
138Regulation of autophagy_Homo sapiens_hsa041400.37375090
139Dorso-ventral axis formation_Homo sapiens_hsa043200.34543177
140Basal transcription factors_Homo sapiens_hsa030220.33878765
141Phototransduction_Homo sapiens_hsa047440.33010346
142Renin secretion_Homo sapiens_hsa049240.32891182
143Vibrio cholerae infection_Homo sapiens_hsa051100.29858644
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29532827
145Tight junction_Homo sapiens_hsa045300.27922439
146Graft-versus-host disease_Homo sapiens_hsa053320.18173238
147Serotonergic synapse_Homo sapiens_hsa047260.18085767
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17918321

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