GCH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.16914839
2L-phenylalanine catabolic process (GO:0006559)7.16914839
3L-phenylalanine metabolic process (GO:0006558)6.83186482
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.83186482
5aromatic amino acid family catabolic process (GO:0009074)6.09938676
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.26882735
7tryptophan catabolic process (GO:0006569)5.15007984
8indole-containing compound catabolic process (GO:0042436)5.15007984
9indolalkylamine catabolic process (GO:0046218)5.15007984
10tryptophan metabolic process (GO:0006568)5.04414167
11bile acid biosynthetic process (GO:0006699)5.04400865
12kynurenine metabolic process (GO:0070189)5.00709919
13urea metabolic process (GO:0019627)4.91497969
14urea cycle (GO:0000050)4.91497969
15cysteine metabolic process (GO:0006534)4.86383102
16protein carboxylation (GO:0018214)4.83103089
17peptidyl-glutamic acid carboxylation (GO:0017187)4.83103089
18tyrosine metabolic process (GO:0006570)4.80834726
19aromatic amino acid family metabolic process (GO:0009072)4.77852947
20regulation of vitamin D biosynthetic process (GO:0060556)4.67321768
21sulfur amino acid catabolic process (GO:0000098)4.66708823
22glyoxylate metabolic process (GO:0046487)4.65660451
23high-density lipoprotein particle remodeling (GO:0034375)4.65426555
24complement activation, alternative pathway (GO:0006957)4.57758700
25negative regulation of fibrinolysis (GO:0051918)4.56925471
26type I interferon signaling pathway (GO:0060337)4.56748492
27cellular response to type I interferon (GO:0071357)4.56748492
28nitrogen cycle metabolic process (GO:0071941)4.56197126
29alpha-linolenic acid metabolic process (GO:0036109)4.53056216
30response to type I interferon (GO:0034340)4.49873291
31negative regulation of interleukin-12 production (GO:0032695)4.46969405
32bile acid metabolic process (GO:0008206)4.43574540
33regulation of fibrinolysis (GO:0051917)4.43191243
34regulation of protein activation cascade (GO:2000257)4.36771445
35indolalkylamine metabolic process (GO:0006586)4.30211500
36regulation of chronic inflammatory response (GO:0002676)4.27739463
37serine family amino acid catabolic process (GO:0009071)4.27123906
38regulation of interferon-alpha production (GO:0032647)4.22595851
39regulation of T-helper 1 cell differentiation (GO:0045625)4.19631114
40response to peptidoglycan (GO:0032494)4.19623471
41acylglycerol homeostasis (GO:0055090)4.19153775
42triglyceride homeostasis (GO:0070328)4.19153775
43bile acid and bile salt transport (GO:0015721)4.13947045
44reverse cholesterol transport (GO:0043691)4.12424484
45homocysteine metabolic process (GO:0050667)4.08465759
46regulation of complement activation (GO:0030449)4.08214650
47regulation of cholesterol esterification (GO:0010872)4.03551660
48phospholipid efflux (GO:0033700)3.99801451
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.97334041
50plasma lipoprotein particle clearance (GO:0034381)3.96552290
51macrophage activation involved in immune response (GO:0002281)3.96281314
52regulation of triglyceride catabolic process (GO:0010896)3.94902002
53intestinal cholesterol absorption (GO:0030299)3.94578319
54protein-lipid complex remodeling (GO:0034368)3.94470301
55macromolecular complex remodeling (GO:0034367)3.94470301
56plasma lipoprotein particle remodeling (GO:0034369)3.94470301
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.92213538
58alkaloid metabolic process (GO:0009820)3.88608334
59regulation of interferon-beta biosynthetic process (GO:0045357)3.86075612
60alpha-amino acid catabolic process (GO:1901606)3.85389507
61aldehyde catabolic process (GO:0046185)3.84180958
62regulation of cholesterol homeostasis (GO:2000188)3.83362513
63positive regulation of gamma-delta T cell activation (GO:0046645)3.82579845
64coenzyme catabolic process (GO:0009109)3.82315773
65amino-acid betaine metabolic process (GO:0006577)3.81628469
66negative regulation of cholesterol transport (GO:0032375)3.80999902
67negative regulation of sterol transport (GO:0032372)3.80999902
68regulation of vitamin metabolic process (GO:0030656)3.80007764
69positive regulation of interferon-alpha production (GO:0032727)3.77852558
70COPI coating of Golgi vesicle (GO:0048205)3.73137333
71Golgi transport vesicle coating (GO:0048200)3.73137333
72lysine metabolic process (GO:0006553)3.70631808
73lysine catabolic process (GO:0006554)3.70631808
74positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.69489650
75cellular ketone body metabolic process (GO:0046950)3.68360289
76negative regulation of cell killing (GO:0031342)3.66908924
77negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.66908924
78production of molecular mediator involved in inflammatory response (GO:0002532)3.65701400
79benzene-containing compound metabolic process (GO:0042537)3.63692525
80cholesterol efflux (GO:0033344)3.63351778
81regulation of cytokine secretion involved in immune response (GO:0002739)3.63341893
82positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63215350
83interferon-gamma-mediated signaling pathway (GO:0060333)3.59583961
84positive regulation of heat generation (GO:0031652)3.59568871
85positive regulation of type 2 immune response (GO:0002830)3.58823702
86positive regulation of chemokine biosynthetic process (GO:0045080)3.57859278
87imidazole-containing compound metabolic process (GO:0052803)3.56922835
88cellular amino acid catabolic process (GO:0009063)3.55648955
89cellular biogenic amine catabolic process (GO:0042402)3.54699409
90amine catabolic process (GO:0009310)3.54699409
91cofactor catabolic process (GO:0051187)3.54183986
92glycine metabolic process (GO:0006544)3.53903251
93immunoglobulin mediated immune response (GO:0016064)3.53326470
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.48442698
95regulation of fever generation (GO:0031620)3.45553080
96regulation of podosome assembly (GO:0071801)3.44818001
97cellular glucuronidation (GO:0052695)3.44037221
98positive regulation by symbiont of host defense response (GO:0052509)3.43003471
99modulation by symbiont of host defense response (GO:0052031)3.43003471
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.43003471
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.43003471
102positive regulation by organism of defense response of other organism involved in symbiotic interact3.43003471
103modulation by symbiont of host immune response (GO:0052553)3.43003471
104plasma lipoprotein particle assembly (GO:0034377)3.39584274
105serine family amino acid metabolic process (GO:0009069)3.37035576
106cellular modified amino acid catabolic process (GO:0042219)3.34712465
107arginine metabolic process (GO:0006525)3.33965752
108drug catabolic process (GO:0042737)3.33580441
109glutamate metabolic process (GO:0006536)3.33385117
110acute-phase response (GO:0006953)3.32827520
111fibrinolysis (GO:0042730)3.32059288
112regulation of chemokine biosynthetic process (GO:0045073)3.31739405
113defense response to protozoan (GO:0042832)3.27924895
114COPII vesicle coating (GO:0048208)3.26256130
115positive regulation of fatty acid biosynthetic process (GO:0045723)3.26059987
116regulation of bile acid biosynthetic process (GO:0070857)3.25846321
117regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.25598369
118blood coagulation, intrinsic pathway (GO:0007597)3.24169054
119endocrine pancreas development (GO:0031018)3.23683718
120neutrophil activation involved in immune response (GO:0002283)3.23661440
121NIK/NF-kappaB signaling (GO:0038061)3.22374205
122regulation of interleukin-12 production (GO:0032655)3.21929510
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.21251625
124positive regulation of lipoprotein lipase activity (GO:0051006)3.20376018
125positive regulation of triglyceride lipase activity (GO:0061365)3.20376018
126urate metabolic process (GO:0046415)3.20258009
127organic acid catabolic process (GO:0016054)3.20122039
128carboxylic acid catabolic process (GO:0046395)3.20122039
129cholesterol homeostasis (GO:0042632)3.19646943
130uronic acid metabolic process (GO:0006063)3.19443587
131glucuronate metabolic process (GO:0019585)3.19443587
132positive regulation of NF-kappaB import into nucleus (GO:0042346)3.18554988
133lipoprotein metabolic process (GO:0042157)3.17758490
134drug transmembrane transport (GO:0006855)3.16160000
135antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16051064
136sterol homeostasis (GO:0055092)3.15249422
137ketone body metabolic process (GO:1902224)3.14610182
138response to protozoan (GO:0001562)3.13956154
139phospholipid homeostasis (GO:0055091)3.12842049
140antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.11478424
141positive regulation of lipid catabolic process (GO:0050996)3.11172629
142complement activation, classical pathway (GO:0006958)3.10888764
143low-density lipoprotein particle remodeling (GO:0034374)3.10642939
144regulation of cholesterol biosynthetic process (GO:0045540)3.10247348
145regulation of T cell tolerance induction (GO:0002664)3.09699418
146protein activation cascade (GO:0072376)3.09499714
147regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09235846
148positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.09086235
149positive regulation of interferon-beta production (GO:0032728)3.09038358
150positive regulation of interleukin-12 production (GO:0032735)3.08368952
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06147754
152T-helper 1 type immune response (GO:0042088)3.04541064
153T cell migration (GO:0072678)3.04324591
154detection of other organism (GO:0098543)3.03182241
155regulation of interleukin-8 biosynthetic process (GO:0045414)3.01811509
156negative regulation of viral genome replication (GO:0045071)3.00261432
157negative regulation of cytokine production involved in immune response (GO:0002719)2.98872352
158positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98784942
159negative regulation of T cell mediated immunity (GO:0002710)2.92997100
160interferon-gamma secretion (GO:0072643)2.92355134
161negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.91927592
162modulation of growth of symbiont involved in interaction with host (GO:0044144)2.91927592
163regulation of growth of symbiont in host (GO:0044126)2.91927592
164negative regulation of growth of symbiont in host (GO:0044130)2.91927592
165antigen processing and presentation of endogenous antigen (GO:0019883)2.91703540
166positive regulation of nitric oxide biosynthetic process (GO:0045429)2.91543762
167regulation of gamma-delta T cell activation (GO:0046643)2.90926463
168germinal center formation (GO:0002467)2.90746192
169detection of molecule of bacterial origin (GO:0032490)2.90524881
170positive regulation of cellular amide metabolic process (GO:0034250)2.90254935
171macrophage activation (GO:0042116)2.87224120
172regulation of T-helper cell differentiation (GO:0045622)2.86680984
173positive regulation of acute inflammatory response (GO:0002675)2.83626790
174positive regulation of humoral immune response (GO:0002922)2.81628815
175regulation of type 2 immune response (GO:0002828)2.80567837
176myeloid dendritic cell differentiation (GO:0043011)2.80420641
177regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79913311
178detection of bacterium (GO:0016045)2.79367679
179positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75986441
180cellular response to interferon-gamma (GO:0071346)2.74002882
181regulation of regulatory T cell differentiation (GO:0045589)2.72814306
182positive regulation of interleukin-6 production (GO:0032755)2.71964641
183B cell mediated immunity (GO:0019724)2.70926141
184regulation of tolerance induction (GO:0002643)2.70523490
185regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69385835
186regulation of NF-kappaB import into nucleus (GO:0042345)2.69185097
187positive regulation of cAMP-mediated signaling (GO:0043950)2.68547187
188regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68137269
189* response to interferon-gamma (GO:0034341)2.67762856
190positive regulation of T-helper cell differentiation (GO:0045624)2.67473545
191negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.65346370
192lymphocyte chemotaxis (GO:0048247)2.64537869
193negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.63925920
194positive regulation of interleukin-10 production (GO:0032733)2.63822618
195regulation of antigen processing and presentation (GO:0002577)2.63335503
196regulation of inflammatory response to antigenic stimulus (GO:0002861)2.61418704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.40129079
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.40922822
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.95909309
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.70166165
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.92650976
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.85204697
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24304152
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72746919
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.72042407
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51073552
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.27528279
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.26815569
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.26430483
14EGR1_19374776_ChIP-ChIP_THP-1_Human3.15430986
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.90994918
16GATA1_22025678_ChIP-Seq_K562_Human2.66403161
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.65316421
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.56792106
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43586009
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1503160
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96082651
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95711805
23RUNX_20019798_ChIP-Seq_JUKART_Human1.94541984
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83646827
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82717032
26CLOCK_20551151_ChIP-Seq_293T_Human1.75107132
27MYB_26560356_Chip-Seq_TH2_Human1.71838279
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.68220512
29VDR_24787735_ChIP-Seq_THP-1_Human1.67494810
30SPI1_23547873_ChIP-Seq_NB4_Human1.65020325
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62913723
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58489231
33SPI1_23127762_ChIP-Seq_K562_Human1.57060852
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56910867
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55360127
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48822619
37* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46876212
38* GATA3_26560356_Chip-Seq_TH2_Human1.40338456
39MYB_26560356_Chip-Seq_TH1_Human1.39339274
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.36383498
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34673896
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.32017543
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.26625452
44HTT_18923047_ChIP-ChIP_STHdh_Human1.26073466
45VDR_24763502_ChIP-Seq_THP-1_Human1.25484700
46* PU_27001747_Chip-Seq_BMDM_Mouse1.22276553
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22186143
48* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19868770
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.17083704
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13816723
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.12466504
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11170425
53TFEB_21752829_ChIP-Seq_HELA_Human1.09701962
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09078263
55MAF_26560356_Chip-Seq_TH1_Human1.08154482
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03562595
57GATA4_25053715_ChIP-Seq_YYC3_Human1.01967640
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01375134
59IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.99637192
60SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99254659
61SCL_19346495_ChIP-Seq_HPC-7_Human0.98835438
62RXRA_24833708_ChIP-Seq_LIVER_Mouse0.98735039
63NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95393682
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95172666
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94678252
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94144753
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91086641
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89092339
69GATA2_21666600_ChIP-Seq_HMVEC_Human0.87430390
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87353480
71ESR1_21235772_ChIP-Seq_MCF-7_Human0.85819117
72SMRT_27268052_Chip-Seq_Bcells_Human0.85646485
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85449134
74KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84568284
75IRF8_21731497_ChIP-ChIP_J774_Mouse0.83550675
76RARA_24833708_ChIP-Seq_LIVER_Mouse0.83510315
77* IRF8_27001747_Chip-Seq_BMDM_Mouse0.83470177
78FOXA1_25552417_ChIP-Seq_VCAP_Human0.83398532
79SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80997125
80AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80907913
81GATA1_19941826_ChIP-Seq_K562_Human0.79635832
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.79433212
83STAT1_20625510_ChIP-Seq_HELA_Human0.77575696
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.76922762
85ZNF263_19887448_ChIP-Seq_K562_Human0.76183147
86UTX_26944678_Chip-Seq_JUKART_Human0.75867054
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.75086870
88ESR2_21235772_ChIP-Seq_MCF-7_Human0.74911169
89RARB_24833708_ChIP-Seq_LIVER_Mouse0.74801127
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74205503
91FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.73502003
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71664407
93GATA6_25053715_ChIP-Seq_YYC3_Human0.71145356
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71058056
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70682616
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.70432659
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68757433
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.68485379
99SOX2_20726797_ChIP-Seq_SW620_Human0.68449185
100GATA1_19941827_ChIP-Seq_MEL86_Mouse0.68123709
101BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67483975
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67386455
103GATA3_26560356_Chip-Seq_TH1_Human0.66664364
104GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.66195268
105MYB_21317192_ChIP-Seq_ERMYB_Mouse0.66170479
106SUZ12_18555785_Chip-Seq_ESCs_Mouse0.66026416
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.65998045
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.65728284
109ERG_20517297_ChIP-Seq_VCAP_Human0.65099238
110LXR_22292898_ChIP-Seq_THP-1_Human0.64117019
111AR_20517297_ChIP-Seq_VCAP_Human0.63819366
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63305037
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.63245504
114PU1_27457419_Chip-Seq_LIVER_Mouse0.63174214
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63137206
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.62726094
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.62379653
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61926850
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.61647313
120CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61286467
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61201308
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60493075
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.59926011
124GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.58564969
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.58266091
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.57833239
127PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.57546372
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.57354095
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57208033
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.56137402
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.55733062
132* GATA3_24758297_ChIP-Seq_MCF-7_Human0.55195215
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.54180743
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.53481347
135* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.53228481
136GATA2_19941826_ChIP-Seq_K562_Human0.52831552
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51755999
138STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51031841
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.50867584
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.50452690
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.49106474
142MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.48516410
143BCOR_27268052_Chip-Seq_Bcells_Human0.48167441
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.47822018
145NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.47623313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.13120958
2MP0005360_urolithiasis5.85021390
3MP0005365_abnormal_bile_salt5.52677119
4MP0005085_abnormal_gallbladder_physiolo5.41789758
5MP0008875_abnormal_xenobiotic_pharmacok4.28537706
6MP0003195_calcinosis3.95621331
7MP0003252_abnormal_bile_duct3.70140429
8MP0009840_abnormal_foam_cell3.61003770
9MP0003806_abnormal_nucleotide_metabolis3.30808326
10MP0005083_abnormal_biliary_tract3.06884261
11MP0010329_abnormal_lipoprotein_level2.87701995
12MP0002148_abnormal_hypersensitivity_rea2.87373883
13MP0002138_abnormal_hepatobiliary_system2.63699678
14MP0005000_abnormal_immune_tolerance2.63310288
15MP0005671_abnormal_response_to2.50033390
16MP0004510_myositis2.45817690
17MP0005332_abnormal_amino_acid2.39040637
18MP0001666_abnormal_nutrient_absorption2.35752804
19MP0001800_abnormal_humoral_immune2.22090486
20MP0000609_abnormal_liver_physiology2.14236305
21MP0003868_abnormal_feces_composition2.11324912
22MP0002723_abnormal_immune_serum2.07730827
23MP0002452_abnormal_antigen_presenting2.03070783
24MP0002118_abnormal_lipid_homeostasis1.96736515
25MP0003191_abnormal_cellular_cholesterol1.88088977
26MP0004019_abnormal_vitamin_homeostasis1.83768846
27MP0010155_abnormal_intestine_physiology1.77178166
28MP0005220_abnormal_exocrine_pancreas1.76753402
29MP0001819_abnormal_immune_cell1.70455774
30MP0005319_abnormal_enzyme/_coenzyme1.69973328
31MP0002420_abnormal_adaptive_immunity1.69761155
32MP0002693_abnormal_pancreas_physiology1.68381263
33MP0009643_abnormal_urine_homeostasis1.65653225
34MP0003075_altered_response_to1.64760521
35MP0001944_abnormal_pancreas_morphology1.55170322
36MP0001764_abnormal_homeostasis1.54283700
37MP0010234_abnormal_vibrissa_follicle1.52213188
38MP0008004_abnormal_stomach_pH1.50588620
39MP0005310_abnormal_salivary_gland1.50397418
40MP0002078_abnormal_glucose_homeostasis1.47858348
41MP0002877_abnormal_melanocyte_morpholog1.47408964
42MP0002405_respiratory_system_inflammati1.46331979
43MP0009333_abnormal_splenocyte_physiolog1.40158461
44MP0002909_abnormal_adrenal_gland1.39949894
45MP0002163_abnormal_gland_morphology1.37437865
46MP0005058_abnormal_lysosome_morphology1.35680499
47MP0005451_abnormal_body_composition1.33081732
48MP0001853_heart_inflammation1.32995605
49MP0004043_abnormal_pH_regulation1.32437086
50MP0002332_abnormal_exercise_endurance1.32128918
51MP0005584_abnormal_enzyme/coenzyme_acti1.27405331
52MP0003186_abnormal_redox_activity1.27030435
53MP0005166_decreased_susceptibility_to1.25812198
54MP0005167_abnormal_blood-brain_barrier1.25617435
55MP0003763_abnormal_thymus_physiology1.23851859
56MP0000716_abnormal_immune_system1.22001115
57MP0005636_abnormal_mineral_homeostasis1.20315659
58MP0003690_abnormal_glial_cell1.19013941
59MP0003724_increased_susceptibility_to1.18663541
60MP0003183_abnormal_peptide_metabolism1.18346177
61MP0000598_abnormal_liver_morphology1.17849372
62MP0002006_tumorigenesis1.17591561
63MP0005379_endocrine/exocrine_gland_phen1.17460182
64MP0003656_abnormal_erythrocyte_physiolo1.16750630
65MP0008469_abnormal_protein_level1.13737267
66MP0001545_abnormal_hematopoietic_system1.11808379
67MP0005397_hematopoietic_system_phenotyp1.11808379
68MP0000013_abnormal_adipose_tissue1.11149028
69MP0001756_abnormal_urination1.11029134
70MP0003453_abnormal_keratinocyte_physiol1.09565167
71MP0005408_hypopigmentation1.09098897
72MP0002398_abnormal_bone_marrow1.08672845
73MP0003436_decreased_susceptibility_to1.08092770
74MP0009764_decreased_sensitivity_to1.06345997
75MP0005535_abnormal_body_temperature1.05807685
76MP0009278_abnormal_bone_marrow1.05055835
77MP0009697_abnormal_copulation1.03830690
78MP0001501_abnormal_sleep_pattern1.03294790
79MP0009642_abnormal_blood_homeostasis1.02204735
80MP0000604_amyloidosis1.00886603
81MP0002166_altered_tumor_susceptibility1.00649118
82MP0002837_dystrophic_cardiac_calcinosis0.99488203
83MP0003448_altered_tumor_morphology0.98327132
84MP0002998_abnormal_bone_remodeling0.97760012
85MP0000689_abnormal_spleen_morphology0.97743418
86MP0008057_abnormal_DNA_replication0.97481821
87MP0009763_increased_sensitivity_to0.97450108
88MP0002928_abnormal_bile_duct0.96476541
89MP0010386_abnormal_urinary_bladder0.96133954
90MP0000343_altered_response_to0.94592087
91MP0010352_gastrointestinal_tract_polyps0.94321181
92MP0005084_abnormal_gallbladder_morpholo0.94108343
93MP0000858_altered_metastatic_potential0.93669339
94MP0004264_abnormal_extraembryonic_tissu0.88710801
95MP0002429_abnormal_blood_cell0.88686676
96MP0002722_abnormal_immune_system0.88048711
97MP0005164_abnormal_response_to0.87499120
98MP0003953_abnormal_hormone_level0.87424457
99MP0001873_stomach_inflammation0.86602290
100MP0002876_abnormal_thyroid_physiology0.86529099
101MP0003300_gastrointestinal_ulcer0.85451751
102MP0005334_abnormal_fat_pad0.84746324
103MP0006054_spinal_hemorrhage0.84674753
104MP0002277_abnormal_respiratory_mucosa0.84578388
105MP0006036_abnormal_mitochondrial_physio0.84499103
106MP0002254_reproductive_system_inflammat0.83313293
107MP0005464_abnormal_platelet_physiology0.80418607
108MP0003045_fibrosis0.79490764
109MP0000639_abnormal_adrenal_gland0.77404816
110MP0003283_abnormal_digestive_organ0.76503036
111MP0005448_abnormal_energy_balance0.76137749
112MP0004947_skin_inflammation0.75905617
113MP0001661_extended_life_span0.74489057
114MP0001845_abnormal_inflammatory_respons0.72942839
115MP0006082_CNS_inflammation0.72024366
116MP0009765_abnormal_xenobiotic_induced0.71936106
117MP0003866_abnormal_defecation0.70637050
118MP0002971_abnormal_brown_adipose0.70059058
119MP0009780_abnormal_chondrocyte_physiolo0.69807280
120MP0003172_abnormal_lysosome_physiology0.68217682
121MP0009785_altered_susceptibility_to0.68096960
122MP0005376_homeostasis/metabolism_phenot0.65155626
123MP0003879_abnormal_hair_cell0.64864020
124MP0001765_abnormal_ion_homeostasis0.64467083
125MP0004782_abnormal_surfactant_physiolog0.62065932
126MP0004883_abnormal_blood_vessel0.61542913
127MP0002136_abnormal_kidney_physiology0.58331925
128MP0005647_abnormal_sex_gland0.57999701
129MP0003959_abnormal_lean_body0.57933198
130MP0003303_peritoneal_inflammation0.57088179
131MP0005670_abnormal_white_adipose0.56566079
132MP0002419_abnormal_innate_immunity0.54705927
133MP0000230_abnormal_systemic_arterial0.54632885
134MP0002638_abnormal_pupillary_reflex0.53450337
135MP0005025_abnormal_response_to0.52794519
136MP0004130_abnormal_muscle_cell0.52788217
137MP0010368_abnormal_lymphatic_system0.52194698
138MP0000538_abnormal_urinary_bladder0.52140398
139MP0001533_abnormal_skeleton_physiology0.51658963
140MP0000685_abnormal_immune_system0.50771864
141MP0003638_abnormal_response/metabolism_0.50567489
142MP0005266_abnormal_metabolism0.50035894
143MP0005395_other_phenotype0.49797679
144MP0001835_abnormal_antigen_presentation0.48848579
145MP0000003_abnormal_adipose_tissue0.48597723
146MP0009672_abnormal_birth_weight0.46979808
147MP0001790_abnormal_immune_system0.46497333
148MP0005387_immune_system_phenotype0.46497333
149MP0002970_abnormal_white_adipose0.46271863

Predicted human phenotypes

RankGene SetZ-score
1* Abnormality of aromatic amino acid family metabolism (HP:0004338)6.77951688
2Intrahepatic cholestasis (HP:0001406)6.03065642
3Abnormality of monocarboxylic acid metabolism (HP:0010996)5.68631262
4Hypoglycemic coma (HP:0001325)5.64443700
5Deep venous thrombosis (HP:0002625)5.52741598
6Xanthomatosis (HP:0000991)5.43753855
7Prolonged partial thromboplastin time (HP:0003645)5.39641431
8Optic neuritis (HP:0100653)5.23585879
9Retrobulbar optic neuritis (HP:0100654)5.23585879
10Stomatitis (HP:0010280)5.05405554
11Orchitis (HP:0100796)4.96778762
12Hypobetalipoproteinemia (HP:0003563)4.87341013
13Hypoglycemic seizures (HP:0002173)4.76141651
14Abnormality of macrophages (HP:0004311)4.68264645
15Hyperinsulinemic hypoglycemia (HP:0000825)4.53503750
16Hyperlipoproteinemia (HP:0010980)4.51352449
17Myositis (HP:0100614)4.45391759
18Recurrent bacterial skin infections (HP:0005406)4.37899373
19Abnormality of liposaccharide metabolism (HP:0010968)4.34244181
20Abnormality of glycosphingolipid metabolism (HP:0004343)4.34244181
21Abnormality of glycolipid metabolism (HP:0010969)4.34244181
22Abnormality of the common coagulation pathway (HP:0010990)4.21999763
23Ketosis (HP:0001946)4.21151046
24Complement deficiency (HP:0004431)4.16010063
25Eczematoid dermatitis (HP:0000976)4.12136020
26Abnormality of the intrinsic pathway (HP:0010989)4.03661459
27Joint hemorrhage (HP:0005261)3.97400038
28Ketoacidosis (HP:0001993)3.96250761
29Recurrent abscess formation (HP:0002722)3.91673644
30Conjugated hyperbilirubinemia (HP:0002908)3.82335010
31Epidermoid cyst (HP:0200040)3.80167581
32Symptomatic seizures (HP:0011145)3.73437291
33Hypolipoproteinemia (HP:0010981)3.69499064
34Hyperglycemia (HP:0003074)3.67212376
35Fat malabsorption (HP:0002630)3.62347053
36Hyperammonemia (HP:0001987)3.55781407
37Keratoconjunctivitis sicca (HP:0001097)3.51675198
38Late onset (HP:0003584)3.51326670
39Hyperglycinemia (HP:0002154)3.50836178
40Abnormality of glutamine family amino acid metabolism (HP:0010902)3.42669771
41Loss of speech (HP:0002371)3.42031601
42Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.37680777
43Keratoconjunctivitis (HP:0001096)3.35803526
44Abnormality of sulfur amino acid metabolism (HP:0004339)3.35220303
45Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.32467532
46Hypoalphalipoproteinemia (HP:0003233)3.28450959
47Abnormality of methionine metabolism (HP:0010901)3.23673631
48Vasculitis (HP:0002633)3.22587158
49Hyperglycinuria (HP:0003108)3.09744243
50Abnormality of complement system (HP:0005339)3.05230969
51Abnormality of aspartate family amino acid metabolism (HP:0010899)3.04950178
52Gastrointestinal infarctions (HP:0005244)3.04704748
53Mediastinal lymphadenopathy (HP:0100721)3.04573793
54Elevated erythrocyte sedimentation rate (HP:0003565)3.03364796
55Gout (HP:0001997)3.02957671
56Abnormality of purine metabolism (HP:0004352)2.99971085
57Hematochezia (HP:0002573)2.97620091
58Gangrene (HP:0100758)2.96490934
59Malnutrition (HP:0004395)2.95838055
60Hyperbilirubinemia (HP:0002904)2.95654646
61Abnormality of fatty-acid metabolism (HP:0004359)2.94302979
62Abnormality of nucleobase metabolism (HP:0010932)2.93204799
63Skin nodule (HP:0200036)2.92805465
64Generalized aminoaciduria (HP:0002909)2.91011491
65Abnormality of serine family amino acid metabolism (HP:0010894)2.87458472
66Abnormality of glycine metabolism (HP:0010895)2.87458472
67Pulmonary infiltrates (HP:0002113)2.87225722
68Abnormality of the pancreatic islet cells (HP:0006476)2.85139015
69Abnormality of endocrine pancreas physiology (HP:0012093)2.85139015
70Hypercholesterolemia (HP:0003124)2.84066981
71Joint swelling (HP:0001386)2.81181319
72Abnormality of pyrimidine metabolism (HP:0004353)2.79672228
73Hemoptysis (HP:0002105)2.77976507
74Recurrent skin infections (HP:0001581)2.71816672
75Myocardial infarction (HP:0001658)2.67061983
76Anorexia (HP:0002039)2.66303002
77Arterial thrombosis (HP:0004420)2.65627907
78Recurrent gram-negative bacterial infections (HP:0005420)2.65462583
79Recurrent fungal infections (HP:0002841)2.64500236
80Steatorrhea (HP:0002570)2.59756783
81Autoimmune thrombocytopenia (HP:0001973)2.56848451
82* Irritability (HP:0000737)2.54699752
83Increased IgM level (HP:0003496)2.49670159
84Systemic lupus erythematosus (HP:0002725)2.47740349
85T lymphocytopenia (HP:0005403)2.46876507
86Polyneuropathy (HP:0001271)2.44797972
87Disinhibition (HP:0000734)2.43839673
88Hepatocellular carcinoma (HP:0001402)2.43605654
89Insulin-resistant diabetes mellitus (HP:0000831)2.43428657
90Abnormality of serum amino acid levels (HP:0003112)2.42718754
91Amyloidosis (HP:0011034)2.42508480
92Increased CSF protein (HP:0002922)2.42183622
93Glomerulonephritis (HP:0000099)2.41586839
94Abnormality of T cell number (HP:0011839)2.39825464
95Encephalitis (HP:0002383)2.39432084
96Autoimmune hemolytic anemia (HP:0001890)2.39192127
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38856203
98Dicarboxylic aciduria (HP:0003215)2.38856203
99Meningitis (HP:0001287)2.36683783
100Urinary glycosaminoglycan excretion (HP:0003541)2.35539732
101Mucopolysacchariduria (HP:0008155)2.35539732
102Recurrent viral infections (HP:0004429)2.35117054
103Mitral stenosis (HP:0001718)2.33092198
104Metabolic acidosis (HP:0001942)2.32257759
105Pancreatic islet-cell hyperplasia (HP:0004510)2.30495425
106Pulmonary embolism (HP:0002204)2.27742862
107Increased cerebral lipofuscin (HP:0011813)2.27732743
108* Progressive neurologic deterioration (HP:0002344)2.25287452
109Gingivitis (HP:0000230)2.25225356
110Insulin resistance (HP:0000855)2.24665090
111Abnormal gallbladder morphology (HP:0012437)2.23974679
112Delayed CNS myelination (HP:0002188)2.23505908
113Increased serum ferritin (HP:0003281)2.19413490
114Pancreatitis (HP:0001733)2.18100051
115Acne (HP:0001061)2.17841288
116Abnormality of mucopolysaccharide metabolism (HP:0011020)2.17498077
117Abnormality of polysaccharide metabolism (HP:0011012)2.17498077
118Abnormality of glycosaminoglycan metabolism (HP:0004371)2.17498077
119Spontaneous abortion (HP:0005268)2.16704410
120Petechiae (HP:0000967)2.16412275
121Abnormality of calcium-phosphate metabolism (HP:0100530)2.16248345
122Brushfield spots (HP:0001088)2.14255889
123Menorrhagia (HP:0000132)2.12452473
124Abnormal enzyme/coenzyme activity (HP:0012379)2.08729235
125Basal ganglia calcification (HP:0002135)2.08501835
126Abnormality of the pleura (HP:0002103)2.08298094
127Chronic obstructive pulmonary disease (HP:0006510)2.08223657
128Obstructive lung disease (HP:0006536)2.08223657
129Hypergammaglobulinemia (HP:0010702)2.08002072
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.07962860
131Urticaria (HP:0001025)2.07018090
132* Lethargy (HP:0001254)2.06775487
133Dysostosis multiplex (HP:0000943)2.06574671
134Increased IgE level (HP:0003212)2.02771782
135Parakeratosis (HP:0001036)2.02337254
136Acanthocytosis (HP:0001927)2.01269019
137Abnormality of iron homeostasis (HP:0011031)2.01094019
138Leukocytosis (HP:0001974)2.01085503
139Nuclear cataract (HP:0100018)2.00713087
140Metaphyseal irregularity (HP:0003025)2.00356221
141Interstitial pulmonary disease (HP:0006530)1.99396131
142Esophageal varix (HP:0002040)1.98246365
143Chronic otitis media (HP:0000389)1.98016832
144Global brain atrophy (HP:0002283)1.97836936
145Nausea (HP:0002018)1.97621805
146Elevated alkaline phosphatase (HP:0003155)1.97242516
147Acute hepatic failure (HP:0006554)1.96575098
148Gingival bleeding (HP:0000225)1.95468540
149Glycosuria (HP:0003076)1.95298926
150Abnormality of urine glucose concentration (HP:0011016)1.95298926
151Vacuolated lymphocytes (HP:0001922)1.94974490
152Purpura (HP:0000979)1.94174833
153Retinal atrophy (HP:0001105)1.93594347
154Abnormality of alkaline phosphatase activity (HP:0004379)1.93300968
155Abnormal delayed hypersensitivity skin test (HP:0002963)1.92951338
156Neoplasm of the tracheobronchial system (HP:0100552)1.92301602
157Albinism (HP:0001022)1.90353794
158Chronic mucocutaneous candidiasis (HP:0002728)1.89051479
159Recurrent cutaneous fungal infections (HP:0011370)1.89051479
160Alveolar cell carcinoma (HP:0006519)1.88815270
161Renal cortical cysts (HP:0000803)1.87112068
162Abnormality of the basal ganglia (HP:0002134)1.86713321
163Abnormality of transition element cation homeostasis (HP:0011030)1.86527383
164Keratitis (HP:0000491)1.86500340
165* Episodic fever (HP:0001954)1.86334214
166Sensorimotor neuropathy (HP:0007141)1.85880422
167Alkalosis (HP:0001948)1.85578895
168Vertigo (HP:0002321)1.84466794
169Cholelithiasis (HP:0001081)1.84349127
170Neonatal onset (HP:0003623)1.83251389
171Mutism (HP:0002300)1.83228637
172Protuberant abdomen (HP:0001538)1.82603697
173Opisthotonus (HP:0002179)1.82425329
174Increased neuronal autofluorescent lipopigment (HP:0002074)1.82144147
175Gastrointestinal stroma tumor (HP:0100723)1.80674945
176Hypophosphatemia (HP:0002148)1.79626807
177Abnormality of the pericardium (HP:0001697)1.79088967
178Abnormality of the gallbladder (HP:0005264)1.79023462
179Death in childhood (HP:0003819)1.78682425
180Recurrent bronchitis (HP:0002837)1.78082020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.38898981
2ERN14.37772393
3TAOK34.36376286
4BCKDK3.89082767
5MAPK153.59898483
6FGFR43.36293349
7FLT33.16690677
8PASK2.61638758
9SIK12.57864912
10RIPK42.52626241
11TAOK12.49732403
12GRK72.45792876
13BMPR22.35572771
14TXK2.22971123
15MATK2.19586930
16FRK2.18635444
17BLK2.15780456
18IRAK32.12438819
19TAOK21.86588003
20ERBB41.86408626
21TYK21.83040241
22TBK11.81824349
23PRPF4B1.78576530
24EPHA31.78132343
25HIPK21.72362302
26PIK3CG1.67597851
27TRIB31.62425544
28RIPK11.60303161
29ADRBK21.55913360
30FGR1.51375600
31STK241.50836805
32JAK31.48843965
33WNK31.42464345
34MAP3K141.34563676
35MST41.33394282
36MAP3K31.33376753
37MAP3K21.28168848
38MOS1.24581887
39MST1R1.24297411
40JAK21.23258422
41MAP3K11.23165709
42PTK61.21374408
43NTRK11.21203837
44MAP3K91.17886717
45JAK11.16602415
46CDC42BPA1.16293464
47DYRK1B1.12715003
48ZAP701.12623214
49DDR21.11774092
50NEK91.10475230
51LYN1.09169987
52EPHA21.08489198
53IKBKE1.05138339
54MAP2K21.05038912
55ABL21.04247158
56PTK21.04170111
57MAP2K61.03434039
58TNK21.03360046
59DAPK21.00611235
60IRAK10.99196964
61MAPK110.93497731
62MET0.93212053
63MAP3K130.91621706
64CHUK0.90714767
65STK100.90091433
66NLK0.89853111
67ARAF0.89418735
68MAP3K120.88849968
69LCK0.84052831
70MARK30.82932074
71CSK0.81986382
72PKN20.81154539
73EPHB10.79783420
74BRAF0.75552491
75BRSK20.75426868
76STK30.72964508
77YES10.70784918
78KIT0.70404957
79HCK0.70189159
80MAP2K30.68254127
81KDR0.68169339
82TRPM70.67971115
83PDK10.66120129
84NME20.64675538
85IKBKB0.64429690
86IRAK40.63734694
87PIM10.62777927
88ITK0.59171321
89GSK3A0.59054391
90MAP4K10.58921730
91MAP2K40.57927843
92MAP3K110.57843436
93AKT30.56984289
94RPS6KA40.56150678
95EIF2AK30.55802037
96FES0.54899030
97KSR20.53468642
98PRKAA20.51821977
99MAP3K100.51811716
100MAP2K10.51419954
101FGFR30.49899778
102PRKACG0.49377788
103CAMKK20.48902135
104PDGFRA0.48794129
105STK160.47947965
106FER0.47310361
107PRKAA10.47075219
108LATS10.46937540
109PINK10.46586909
110SCYL20.45315691
111IGF1R0.44307503
112BTK0.44121149
113IRAK20.43378719
114TEC0.41707313
115TGFBR20.41701305
116SIK30.41412250
117RET0.40376136
118WNK40.38779423
119ACVR1B0.38080000
120SYK0.37830570
121CSNK1G10.36972847
122MAP3K50.35999651
123PAK30.35062393
124CSNK1G30.34699796
125PIM20.34582244
126CAMK2G0.33848317
127PRKCH0.32167766
128PDPK10.31326330
129MAPK40.31021376
130STK38L0.29968974
131PRKCQ0.29486002
132EGFR0.29408016
133ERBB20.29402722
134CSF1R0.27984717
135CSNK1G20.27938351
136PRKCZ0.26775018
137ABL10.25536891
138GRK60.25503888
139CLK10.23676664
140CDK60.22581626
141INSR0.19998994
142PRKCI0.19690860
143BRD40.17374204
144STK40.17081025
145KSR10.14017578
146MAPKAPK20.13925382
147DYRK30.13366359
148TYRO30.13103328
149STK110.12185134
150CDK120.11365080

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.17201015
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.04198559
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11742827
4Toll-like receptor signaling pathway_Homo sapiens_hsa046203.03505894
5Tryptophan metabolism_Homo sapiens_hsa003802.96794688
6Nitrogen metabolism_Homo sapiens_hsa009102.95280904
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.85110128
8Arginine biosynthesis_Homo sapiens_hsa002202.68156026
9Allograft rejection_Homo sapiens_hsa053302.68144911
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.59999663
11Leishmaniasis_Homo sapiens_hsa051402.52909115
12Complement and coagulation cascades_Homo sapiens_hsa046102.47089696
13Osteoclast differentiation_Homo sapiens_hsa043802.46777789
14Graft-versus-host disease_Homo sapiens_hsa053322.46767218
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38539091
16Rheumatoid arthritis_Homo sapiens_hsa053232.34575740
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32473876
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.27871717
19Fatty acid degradation_Homo sapiens_hsa000712.22423785
20Selenocompound metabolism_Homo sapiens_hsa004502.22378031
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.22183262
22African trypanosomiasis_Homo sapiens_hsa051432.18703376
23Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18432650
24Histidine metabolism_Homo sapiens_hsa003402.17257530
25Sulfur metabolism_Homo sapiens_hsa009202.16311009
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15522621
27Asthma_Homo sapiens_hsa053102.15276699
28Autoimmune thyroid disease_Homo sapiens_hsa053202.07890975
29Intestinal immune network for IgA production_Homo sapiens_hsa046722.07442678
30TNF signaling pathway_Homo sapiens_hsa046682.01880995
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.01266416
32Butanoate metabolism_Homo sapiens_hsa006501.99657180
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97311916
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94199744
35Malaria_Homo sapiens_hsa051441.92002181
36Peroxisome_Homo sapiens_hsa041461.91514114
37Phenylalanine metabolism_Homo sapiens_hsa003601.87478847
38Influenza A_Homo sapiens_hsa051641.86939506
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.85762784
40Tuberculosis_Homo sapiens_hsa051521.85625512
41Measles_Homo sapiens_hsa051621.85575853
42Staphylococcus aureus infection_Homo sapiens_hsa051501.79565238
43Caffeine metabolism_Homo sapiens_hsa002321.67842209
44Tyrosine metabolism_Homo sapiens_hsa003501.66446154
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.60239157
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58113837
47Chemical carcinogenesis_Homo sapiens_hsa052041.57425078
48Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55813509
49Herpes simplex infection_Homo sapiens_hsa051681.54476514
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.54269921
51Fatty acid metabolism_Homo sapiens_hsa012121.48167638
52PPAR signaling pathway_Homo sapiens_hsa033201.47936473
53* Folate biosynthesis_Homo sapiens_hsa007901.47171167
54beta-Alanine metabolism_Homo sapiens_hsa004101.44993458
55Protein export_Homo sapiens_hsa030601.43856696
56Hepatitis C_Homo sapiens_hsa051601.42106748
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.41138253
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40705324
59Hematopoietic cell lineage_Homo sapiens_hsa046401.40449752
60Retinol metabolism_Homo sapiens_hsa008301.39868237
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.38141326
62Toxoplasmosis_Homo sapiens_hsa051451.36279814
63Propanoate metabolism_Homo sapiens_hsa006401.35218836
64B cell receptor signaling pathway_Homo sapiens_hsa046621.34992749
65Starch and sucrose metabolism_Homo sapiens_hsa005001.34573550
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33056579
67ABC transporters_Homo sapiens_hsa020101.29997781
68Bile secretion_Homo sapiens_hsa049761.28386435
69Primary immunodeficiency_Homo sapiens_hsa053401.24673230
70Salmonella infection_Homo sapiens_hsa051321.24475174
71Fat digestion and absorption_Homo sapiens_hsa049751.24225285
72Chemokine signaling pathway_Homo sapiens_hsa040621.20810433
73T cell receptor signaling pathway_Homo sapiens_hsa046601.18789652
74Sulfur relay system_Homo sapiens_hsa041221.14008368
75Fatty acid elongation_Homo sapiens_hsa000621.12130851
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10465367
77Steroid biosynthesis_Homo sapiens_hsa001001.09385891
78Cysteine and methionine metabolism_Homo sapiens_hsa002701.04048615
79Hepatitis B_Homo sapiens_hsa051611.00122664
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99611925
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95914046
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95148247
83Phagosome_Homo sapiens_hsa041450.91484307
84Collecting duct acid secretion_Homo sapiens_hsa049660.90752051
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90674171
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89298600
87Sphingolipid metabolism_Homo sapiens_hsa006000.88705802
88Arginine and proline metabolism_Homo sapiens_hsa003300.87674812
89Pyruvate metabolism_Homo sapiens_hsa006200.87118037
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85925595
91Vitamin B6 metabolism_Homo sapiens_hsa007500.84830145
92Biosynthesis of amino acids_Homo sapiens_hsa012300.84069554
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82694806
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80957285
95Carbon metabolism_Homo sapiens_hsa012000.78401131
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78063168
97Dorso-ventral axis formation_Homo sapiens_hsa043200.76649575
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75765182
99Vitamin digestion and absorption_Homo sapiens_hsa049770.75568316
100Shigellosis_Homo sapiens_hsa051310.67984605
101Prion diseases_Homo sapiens_hsa050200.67321990
102Viral myocarditis_Homo sapiens_hsa054160.65701659
103Acute myeloid leukemia_Homo sapiens_hsa052210.62860842
104Lysine degradation_Homo sapiens_hsa003100.61222112
105Regulation of autophagy_Homo sapiens_hsa041400.61009540
106Pentose phosphate pathway_Homo sapiens_hsa000300.60906553
107Amoebiasis_Homo sapiens_hsa051460.59611717
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58143134
109One carbon pool by folate_Homo sapiens_hsa006700.55284356
110Insulin resistance_Homo sapiens_hsa049310.55032208
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53553603
112Glycerolipid metabolism_Homo sapiens_hsa005610.53438693
113Lysosome_Homo sapiens_hsa041420.52494134
114Galactose metabolism_Homo sapiens_hsa000520.52487322
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.51031758
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50781946
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.50343192
118Apoptosis_Homo sapiens_hsa042100.50113018
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49121145
120Mineral absorption_Homo sapiens_hsa049780.46244060
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44478924
122Epstein-Barr virus infection_Homo sapiens_hsa051690.43905720
123* Metabolic pathways_Homo sapiens_hsa011000.43637760
124Linoleic acid metabolism_Homo sapiens_hsa005910.41704909
125Type I diabetes mellitus_Homo sapiens_hsa049400.41121649
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41010143
127Type II diabetes mellitus_Homo sapiens_hsa049300.40048684
128Glutathione metabolism_Homo sapiens_hsa004800.39685924
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38875579
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.38140015
131FoxO signaling pathway_Homo sapiens_hsa040680.36835047
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36487845
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.33080619
134VEGF signaling pathway_Homo sapiens_hsa043700.31543472
135Legionellosis_Homo sapiens_hsa051340.30272764
136Fructose and mannose metabolism_Homo sapiens_hsa000510.30189297
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30054197
138Cyanoamino acid metabolism_Homo sapiens_hsa004600.26024146
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24926601
140Insulin secretion_Homo sapiens_hsa049110.22197345
141Glucagon signaling pathway_Homo sapiens_hsa049220.21584190
142Bladder cancer_Homo sapiens_hsa052190.21199082
143mTOR signaling pathway_Homo sapiens_hsa041500.20978296
144Other glycan degradation_Homo sapiens_hsa005110.20714843
145Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20425287
146Arachidonic acid metabolism_Homo sapiens_hsa005900.18666810
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18382352
148Ether lipid metabolism_Homo sapiens_hsa005650.18373630
149Ovarian steroidogenesis_Homo sapiens_hsa049130.16508831
150Viral carcinogenesis_Homo sapiens_hsa052030.15776252
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.15654082
152Platelet activation_Homo sapiens_hsa046110.14100115
153Renin-angiotensin system_Homo sapiens_hsa046140.12530972
154Prolactin signaling pathway_Homo sapiens_hsa049170.11813126
155HTLV-I infection_Homo sapiens_hsa051660.10246336
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.10016995
157Circadian rhythm_Homo sapiens_hsa047100.09782653
158Cocaine addiction_Homo sapiens_hsa050300.07937410
159Vibrio cholerae infection_Homo sapiens_hsa051100.07035867
160RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.06192492
161Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04500525
162N-Glycan biosynthesis_Homo sapiens_hsa005100.03176294
163AMPK signaling pathway_Homo sapiens_hsa041520.01669166
164Antigen processing and presentation_Homo sapiens_hsa046120.01403602
165Insulin signaling pathway_Homo sapiens_hsa049100.01201268
166Pertussis_Homo sapiens_hsa05133-0.0107314

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