GCFC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1renal system development (GO:0072001)9.66007516
2regulation of DNA damage checkpoint (GO:2000001)6.99949415
3regulation of double-strand break repair via homologous recombination (GO:0010569)6.70811875
4mitotic G1 DNA damage checkpoint (GO:0031571)6.35962963
5multicellular organismal aging (GO:0010259)6.08798294
6G1 DNA damage checkpoint (GO:0044783)5.89558007
7mitotic G1/S transition checkpoint (GO:0044819)5.54294133
8pre-miRNA processing (GO:0031054)4.95666302
9somatic hypermutation of immunoglobulin genes (GO:0016446)4.80034697
10somatic diversification of immune receptors via somatic mutation (GO:0002566)4.80034697
11mRNA cleavage (GO:0006379)4.74991102
12adenosine metabolic process (GO:0046085)4.66418937
13mitotic sister chromatid cohesion (GO:0007064)4.62500662
14nucleotide-excision repair, DNA damage removal (GO:0000718)4.58909843
15DNA excision (GO:0044349)4.58909843
16regulation of histone H3-K9 methylation (GO:0051570)4.57646617
17double-strand break repair via homologous recombination (GO:0000724)4.48117395
18recombinational repair (GO:0000725)4.44633888
19DNA unwinding involved in DNA replication (GO:0006268)4.41574972
20regulation of meiosis I (GO:0060631)4.29047014
21regulation of double-strand break repair (GO:2000779)4.19979702
22negative regulation of histone methylation (GO:0031061)4.16166250
23nuclear pore organization (GO:0006999)4.12349907
24nuclear pore complex assembly (GO:0051292)4.04760681
25lactate metabolic process (GO:0006089)3.99748618
26DNA double-strand break processing (GO:0000729)3.96087915
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88887198
28peptidyl-lysine trimethylation (GO:0018023)3.88708237
29DNA-dependent DNA replication (GO:0006261)3.82026999
30keratinocyte development (GO:0003334)3.72366258
31maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.67782119
32regulation of DNA endoreduplication (GO:0032875)3.65579155
33histone H3-K9 methylation (GO:0051567)3.59806240
34response to X-ray (GO:0010165)3.57480964
35mitochondrial DNA replication (GO:0006264)3.56818146
36mitotic DNA damage checkpoint (GO:0044773)3.54589358
37intracellular protein transmembrane transport (GO:0065002)3.54391093
38intra-S DNA damage checkpoint (GO:0031573)3.48487391
39telomere maintenance via semi-conservative replication (GO:0032201)3.48266839
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45310619
41double-strand break repair (GO:0006302)3.43815974
42positive regulation by symbiont of host defense response (GO:0052509)3.42914198
43modulation by symbiont of host defense response (GO:0052031)3.42914198
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42914198
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42914198
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.42914198
47modulation by symbiont of host immune response (GO:0052553)3.42914198
48protein K6-linked ubiquitination (GO:0085020)3.42820423
49histone H3-K9 modification (GO:0061647)3.40764828
50transcription-coupled nucleotide-excision repair (GO:0006283)3.39187000
51water-soluble vitamin biosynthetic process (GO:0042364)3.37821778
52DNA geometric change (GO:0032392)3.36700433
53DNA strand elongation involved in DNA replication (GO:0006271)3.36369479
54mitotic recombination (GO:0006312)3.35459106
55male meiosis I (GO:0007141)3.34449415
56base-excision repair (GO:0006284)3.34280805
57non-recombinational repair (GO:0000726)3.34278643
58double-strand break repair via nonhomologous end joining (GO:0006303)3.34278643
59DNA duplex unwinding (GO:0032508)3.33514883
60DNA damage response, signal transduction resulting in transcription (GO:0042772)3.32710873
61tongue development (GO:0043586)3.32391510
62telomere maintenance via recombination (GO:0000722)3.32211016
63mitotic DNA integrity checkpoint (GO:0044774)3.30721689
64pore complex assembly (GO:0046931)3.27140634
65centrosome duplication (GO:0051298)3.25470468
66somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.24630395
67isotype switching (GO:0045190)3.24630395
68somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.24630395
69peptidyl-lysine methylation (GO:0018022)3.24393693
70mitotic chromosome condensation (GO:0007076)3.23482094
71regulation of histone H3-K27 methylation (GO:0061085)3.23099697
72negative regulation of fibroblast apoptotic process (GO:2000270)3.21766991
73somatic diversification of immune receptors (GO:0002200)3.21518361
74ribosomal small subunit assembly (GO:0000028)3.20616042
75somatic cell DNA recombination (GO:0016444)3.20053931
76somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.20053931
77alternative mRNA splicing, via spliceosome (GO:0000380)3.19476372
78DNA strand elongation (GO:0022616)3.17999911
79regulation of cell cycle checkpoint (GO:1901976)3.17621247
80definitive hemopoiesis (GO:0060216)3.16456847
81regulation of cellular senescence (GO:2000772)3.15504228
82regulation of RNA export from nucleus (GO:0046831)3.15297954
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.14542852
84histone mRNA metabolic process (GO:0008334)3.14529863
85regulation of nucleobase-containing compound transport (GO:0032239)3.13925408
86kinetochore organization (GO:0051383)3.13250249
87positive regulation of histone H3-K4 methylation (GO:0051571)3.13041648
88centriole replication (GO:0007099)3.12032899
89sister chromatid segregation (GO:0000819)3.10407869
90T-helper 1 type immune response (GO:0042088)3.10128403
91regulation of histone H3-K4 methylation (GO:0051569)3.09976264
92meiotic chromosome segregation (GO:0045132)3.07855072
93regulation of helicase activity (GO:0051095)3.05716689
94regulation of sister chromatid cohesion (GO:0007063)3.02252950
95positive regulation of gamma-delta T cell activation (GO:0046645)3.01302983
96nucleotide-excision repair (GO:0006289)3.01044128
97mRNA stabilization (GO:0048255)3.00875941
98RNA stabilization (GO:0043489)3.00875941
99reciprocal DNA recombination (GO:0035825)2.99318098
100reciprocal meiotic recombination (GO:0007131)2.99318098
101positive regulation of histone methylation (GO:0031062)2.98914014
102lipopolysaccharide biosynthetic process (GO:0009103)2.98775250
103determination of adult lifespan (GO:0008340)2.98050393
104dentate gyrus development (GO:0021542)2.97044135
105V(D)J recombination (GO:0033151)2.96777687
106histone H3-K4 trimethylation (GO:0080182)2.95737412
107outer ear morphogenesis (GO:0042473)2.95242464
108postreplication repair (GO:0006301)2.95212331
109regulation of Golgi to plasma membrane protein transport (GO:0042996)2.94664844
110regulation of DNA recombination (GO:0000018)2.93304707
111somatic diversification of immunoglobulins (GO:0016445)2.92371384
112DNA recombination (GO:0006310)2.91643590
113DNA replication initiation (GO:0006270)2.90494170
114negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90154631
115negative regulation of translation, ncRNA-mediated (GO:0040033)2.90154631
116regulation of translation, ncRNA-mediated (GO:0045974)2.90154631
117regulation of histone methylation (GO:0031060)2.89981757
118mitotic nuclear envelope disassembly (GO:0007077)2.89323992
119somatic recombination of immunoglobulin gene segments (GO:0016447)2.86468466
120telomere maintenance via telomerase (GO:0007004)2.86005939
121positive regulation of developmental pigmentation (GO:0048087)2.84223438
122mismatch repair (GO:0006298)2.82664269
123mRNA splice site selection (GO:0006376)2.81825052
124DNA topological change (GO:0006265)2.81102062
125protein localization to kinetochore (GO:0034501)2.81037181
126replication fork processing (GO:0031297)2.80542487
127RNA polyadenylation (GO:0043631)2.80498053
128monoubiquitinated protein deubiquitination (GO:0035520)2.79525537
129DNA conformation change (GO:0071103)2.79271643
130resolution of meiotic recombination intermediates (GO:0000712)2.78411556
131regulation of chromatin silencing (GO:0031935)2.77596348
132chromatin assembly or disassembly (GO:0006333)2.77564705
133DNA replication-independent nucleosome organization (GO:0034724)2.77401868
134DNA replication-independent nucleosome assembly (GO:0006336)2.77401868
135response to UV-C (GO:0010225)2.76852211
136telomere maintenance via telomere lengthening (GO:0010833)2.76595976
137protein transmembrane transport (GO:0071806)2.75882234
138spindle assembly involved in mitosis (GO:0090307)2.75853205
139mRNA polyadenylation (GO:0006378)2.75775488
140forebrain neuron differentiation (GO:0021879)2.75569332
141meiosis I (GO:0007127)2.75554283
142regulation of gene silencing (GO:0060968)2.75440904
143cerebral cortex radially oriented cell migration (GO:0021799)2.72601305
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72346683
145nuclear envelope disassembly (GO:0051081)2.72122061
146membrane disassembly (GO:0030397)2.72122061
147histone exchange (GO:0043486)2.71536720
148specification of organ identity (GO:0010092)2.71459295
149regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.69756340
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.68830421
151folic acid-containing compound biosynthetic process (GO:0009396)2.68783539
152chromatin assembly (GO:0031497)2.68525208
153DNA replication-dependent nucleosome organization (GO:0034723)2.68444123
154DNA replication-dependent nucleosome assembly (GO:0006335)2.68444123
155protein localization to chromosome, centromeric region (GO:0071459)2.62801208
156negative regulation of DNA recombination (GO:0045910)2.60863903
157telomere organization (GO:0032200)2.60506846
158telomere maintenance (GO:0000723)2.59735254
159lipopolysaccharide metabolic process (GO:0008653)2.58685153
160translesion synthesis (GO:0019985)2.57929148
161histone mRNA catabolic process (GO:0071044)2.56614792
162chromatin remodeling at centromere (GO:0031055)2.56591357
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55593821
164cell proliferation in forebrain (GO:0021846)2.55391785
165nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.55381981
166sister chromatid cohesion (GO:0007062)2.54553150
167regulation of mRNA stability (GO:0043488)2.53678638
168mitotic sister chromatid segregation (GO:0000070)2.52954635
169positive regulation of chromosome segregation (GO:0051984)2.52411124
170negative regulation of gene silencing (GO:0060969)2.52214455
171negative regulation of RNA splicing (GO:0033119)2.51989121
172heterochromatin organization (GO:0070828)2.50805088
173spindle assembly (GO:0051225)2.49771498
174negative regulation of DNA repair (GO:0045738)2.49704188
175negative regulation of DNA-dependent DNA replication (GO:2000104)2.48331791
176peptidyl-lysine dimethylation (GO:0018027)2.47688189
177regulation of mitotic spindle organization (GO:0060236)2.47188448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.39104208
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.21512734
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.25205965
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14269701
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.95482844
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.91117495
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.69418705
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.66850364
9SCL_19346495_ChIP-Seq_HPC-7_Human2.66425886
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64837207
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63495579
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53414715
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.49272075
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.47393424
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.45400974
16FUS_26573619_Chip-Seq_HEK293_Human2.37889344
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25172725
18MYC_22102868_ChIP-Seq_BL_Human2.17629191
19ZNF274_21170338_ChIP-Seq_K562_Hela2.14981801
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.10655581
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04394645
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02708573
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00845589
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00084472
25E2F7_22180533_ChIP-Seq_HELA_Human10.6089531
26VDR_22108803_ChIP-Seq_LS180_Human1.97792712
27ELK1_19687146_ChIP-ChIP_HELA_Human1.95371431
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.87398899
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.86942164
30AR_21572438_ChIP-Seq_LNCaP_Human1.86766517
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.84690722
32CBP_20019798_ChIP-Seq_JUKART_Human1.82397255
33IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.82397255
34AR_21909140_ChIP-Seq_LNCAP_Human1.82353053
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81561932
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.81497803
37MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81415825
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.79882085
39CIITA_25753668_ChIP-Seq_RAJI_Human1.76040491
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75751149
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.74702098
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73534337
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73092965
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.71551254
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71385158
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71232332
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71129874
48ER_23166858_ChIP-Seq_MCF-7_Human1.68533730
49GBX2_23144817_ChIP-Seq_PC3_Human1.64756304
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.62887053
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62571188
52MYB_26560356_Chip-Seq_TH2_Human1.61861775
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60561599
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.59769968
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58587966
56VDR_21846776_ChIP-Seq_THP-1_Human1.58177091
57TAF15_26573619_Chip-Seq_HEK293_Human1.57674097
58MYB_26560356_Chip-Seq_TH1_Human1.53149060
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.52318628
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.51781455
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51491997
62VDR_23849224_ChIP-Seq_CD4+_Human1.50390085
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.50056638
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.49876138
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49291952
66MYC_18940864_ChIP-ChIP_HL60_Human1.47225321
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47148751
68TFEB_21752829_ChIP-Seq_HELA_Human1.46356864
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42677879
70CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42229847
71SPI1_23547873_ChIP-Seq_NB4_Human1.42199862
72BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38886838
73NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38408152
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37175467
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37103299
76XRN2_22483619_ChIP-Seq_HELA_Human1.36787470
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36291610
78STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.35160932
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34578785
80P300_19829295_ChIP-Seq_ESCs_Human1.34413287
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34247368
82NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33376083
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32335576
84BCAT_22108803_ChIP-Seq_LS180_Human1.31502401
85CDX2_22108803_ChIP-Seq_LS180_Human1.30981354
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30184426
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29952445
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29486077
89FOXP3_21729870_ChIP-Seq_TREG_Human1.28960136
90FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.28648707
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28372660
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27794228
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27766946
94MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27630682
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.27324822
96EWS_26573619_Chip-Seq_HEK293_Human1.27105103
97TCF4_23295773_ChIP-Seq_U87_Human1.26991334
98SMAD4_21799915_ChIP-Seq_A2780_Human1.23906721
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22829657
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.21666041
101* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20855647
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.19783493
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18565637
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17820940
105FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.17371929
106EST1_17652178_ChIP-ChIP_JURKAT_Human1.16281050
107EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15250661
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15026937
109KDM5A_27292631_Chip-Seq_BREAST_Human1.14191916
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13522970
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13158606
112FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.12715165
113NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11581181
114TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10619036
115AR_25329375_ChIP-Seq_VCAP_Human1.10463782
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.10063817
117SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09780488
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.08787402
119OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06967217
120P53_22387025_ChIP-Seq_ESCs_Mouse1.06274239
121STAT3_23295773_ChIP-Seq_U87_Human1.06144092
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06053872
123SOX2_19829295_ChIP-Seq_ESCs_Human1.05664725
124NANOG_19829295_ChIP-Seq_ESCs_Human1.05664725
125RUNX_20019798_ChIP-Seq_JUKART_Human1.04276831
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.03959184
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03783551
128FLI1_21867929_ChIP-Seq_TH2_Mouse1.03492744
129UTX_26944678_Chip-Seq_JUKART_Human1.03414056
130NANOG_18555785_Chip-Seq_ESCs_Mouse1.03024095
131CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02507931
132STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02484265
133MAF_26560356_Chip-Seq_TH1_Human1.02363694
134BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02255769
135PU_27001747_Chip-Seq_BMDM_Mouse1.02077201
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01539501
137P300_18555785_Chip-Seq_ESCs_Mouse1.01319076
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00906930
139EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00388496
140KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00044739
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99812981
142FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99630671
143PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99511472
144TCF7_22412390_ChIP-Seq_EML_Mouse0.99029404
145RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98674706
146VDR_24763502_ChIP-Seq_THP-1_Human0.97879418
147TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97845249
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97763845
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.97188980
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.96628852
151TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95819142
152AR_20517297_ChIP-Seq_VCAP_Human0.95212938
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94820126
154CMYC_18555785_Chip-Seq_ESCs_Mouse0.94206385
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93962289
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93660322
157NOTCH1_21737748_ChIP-Seq_TLL_Human0.92780721
158MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91869773
159ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91186477
160GATA3_27048872_Chip-Seq_THYMUS_Human0.90138144
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89765738
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89762399
163SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89726807
164MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88718953
165RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88459331
166KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87267628
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85548014
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.84393719
169PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83757041
170RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83355823
171IRF1_19129219_ChIP-ChIP_H3396_Human0.83312219
172ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78832483
173IGF1R_20145208_ChIP-Seq_DFB_Human0.78765658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.31247602
2MP0006292_abnormal_olfactory_placode4.91872941
3MP0000566_synostosis4.35805469
4MP0010094_abnormal_chromosome_stability3.38077646
5MP0008995_early_reproductive_senescence3.33250968
6MP0002396_abnormal_hematopoietic_system2.76209839
7MP0003111_abnormal_nucleus_morphology2.63502248
8MP0003077_abnormal_cell_cycle2.50363658
9MP0000383_abnormal_hair_follicle2.48455577
10MP0000569_abnormal_digit_pigmentation2.45734236
11MP0009053_abnormal_anal_canal2.32380771
12MP0010352_gastrointestinal_tract_polyps2.29196664
13MP0008058_abnormal_DNA_repair2.26180503
14MP0008789_abnormal_olfactory_epithelium2.25241632
15MP0010030_abnormal_orbit_morphology2.23739698
16MP0004957_abnormal_blastocyst_morpholog2.18762355
17MP0010678_abnormal_skin_adnexa2.13627770
18MP0005248_abnormal_Harderian_gland2.07406335
19MP0003693_abnormal_embryo_hatching2.01673113
20MP0004808_abnormal_hematopoietic_stem1.88396719
21MP0008007_abnormal_cellular_replicative1.79812281
22MP0010307_abnormal_tumor_latency1.74196532
23MP0003121_genomic_imprinting1.70533021
24MP0002234_abnormal_pharynx_morphology1.70512980
25MP0002398_abnormal_bone_marrow1.69298999
26MP0003786_premature_aging1.68528352
27MP0001835_abnormal_antigen_presentation1.67907993
28MP0000703_abnormal_thymus_morphology1.63891699
29MP0005394_taste/olfaction_phenotype1.63116866
30MP0005499_abnormal_olfactory_system1.63116866
31MP0006276_abnormal_autonomic_nervous1.62342786
32MP0003950_abnormal_plasma_membrane1.61045650
33MP0005647_abnormal_sex_gland1.59895448
34MP0001800_abnormal_humoral_immune1.56551375
35MP0005187_abnormal_penis_morphology1.54367353
36MP0003195_calcinosis1.52812175
37MP0005174_abnormal_tail_pigmentation1.48974560
38MP0002095_abnormal_skin_pigmentation1.47078456
39MP0003763_abnormal_thymus_physiology1.46755459
40MP0002233_abnormal_nose_morphology1.45662149
41MP0008877_abnormal_DNA_methylation1.45137437
42MP0002452_abnormal_antigen_presenting1.44856352
43MP0002722_abnormal_immune_system1.42594718
44MP0000350_abnormal_cell_proliferation1.41229943
45MP0000689_abnormal_spleen_morphology1.39612671
46MP0000685_abnormal_immune_system1.38387474
47MP0000372_irregular_coat_pigmentation1.38283343
48MP0001293_anophthalmia1.36940456
49MP0004185_abnormal_adipocyte_glucose1.36934756
50MP0004043_abnormal_pH_regulation1.35903230
51MP0003385_abnormal_body_wall1.35048851
52MP0002420_abnormal_adaptive_immunity1.34351485
53MP0000716_abnormal_immune_system1.33461696
54MP0002723_abnormal_immune_serum1.33091031
55MP0001819_abnormal_immune_cell1.32889996
56MP0000465_gastrointestinal_hemorrhage1.31595304
57MP0001730_embryonic_growth_arrest1.27039555
58MP0004197_abnormal_fetal_growth/weight/1.26353145
59MP0004215_abnormal_myocardial_fiber1.26196891
60MP0003300_gastrointestinal_ulcer1.26184000
61MP0008872_abnormal_physiological_respon1.26040499
62MP0001986_abnormal_taste_sensitivity1.24213618
63MP0003123_paternal_imprinting1.22922535
64MP0002166_altered_tumor_susceptibility1.19083434
65MP0002429_abnormal_blood_cell1.19047404
66MP0002009_preneoplasia1.15569836
67MP0003938_abnormal_ear_development1.15496423
68MP0003937_abnormal_limbs/digits/tail_de1.15191241
69MP0000631_abnormal_neuroendocrine_gland1.14956491
70MP0005387_immune_system_phenotype1.14423234
71MP0001790_abnormal_immune_system1.14423234
72MP0009703_decreased_birth_body1.14419293
73MP0002938_white_spotting1.13843206
74MP0002084_abnormal_developmental_patter1.12644229
75MP0000490_abnormal_crypts_of1.10663885
76MP0002019_abnormal_tumor_incidence1.10182729
77MP0006072_abnormal_retinal_apoptosis1.09900996
78MP0001545_abnormal_hematopoietic_system1.09429827
79MP0005397_hematopoietic_system_phenotyp1.09429827
80MP0001188_hyperpigmentation1.09298837
81MP0001661_extended_life_span1.08028814
82MP0005025_abnormal_response_to1.07444353
83MP0002249_abnormal_larynx_morphology1.07083223
84MP0005671_abnormal_response_to1.05941895
85MP0002638_abnormal_pupillary_reflex1.05879763
86MP0002111_abnormal_tail_morphology1.04898571
87MP0000733_abnormal_muscle_development1.04573164
88MP0003315_abnormal_perineum_morphology1.02992010
89MP0009333_abnormal_splenocyte_physiolog1.02820239
90MP0001849_ear_inflammation1.02647298
91MP0000647_abnormal_sebaceous_gland1.02454319
92MP0002086_abnormal_extraembryonic_tissu1.01625561
93MP0001697_abnormal_embryo_size1.01158210
94MP0002405_respiratory_system_inflammati1.00404885
95MP0003646_muscle_fatigue1.00348944
96MP0001672_abnormal_embryogenesis/_devel1.00147655
97MP0005380_embryogenesis_phenotype1.00147655
98MP0000049_abnormal_middle_ear1.00144081
99MP0003787_abnormal_imprinting1.00074493
100MP0002419_abnormal_innate_immunity0.99694887
101MP0000579_abnormal_nail_morphology0.99519827
102MP0000639_abnormal_adrenal_gland0.99432799
103MP0002085_abnormal_embryonic_tissue0.98701789
104MP0004145_abnormal_muscle_electrophysio0.98465129
105MP0000537_abnormal_urethra_morphology0.98198239
106MP0005464_abnormal_platelet_physiology0.97163401
107MP0002160_abnormal_reproductive_system0.96865992
108MP0005075_abnormal_melanosome_morpholog0.96331977
109MP0002928_abnormal_bile_duct0.95910229
110MP0000377_abnormal_hair_follicle0.94769796
111MP0009278_abnormal_bone_marrow0.94720445
112MP0005000_abnormal_immune_tolerance0.94312958
113MP0002092_abnormal_eye_morphology0.93592521
114MP0002075_abnormal_coat/hair_pigmentati0.92314956
115MP0000313_abnormal_cell_death0.91988128
116MP0003984_embryonic_growth_retardation0.91951213
117MP0005171_absent_coat_pigmentation0.91419120
118MP0005646_abnormal_pituitary_gland0.91113863
119MP0002080_prenatal_lethality0.90801718
120MP0002088_abnormal_embryonic_growth/wei0.90649552
121MP0002098_abnormal_vibrissa_morphology0.89708903
122MP0000015_abnormal_ear_pigmentation0.89396964
123MP0001984_abnormal_olfaction0.88272887
124MP0001873_stomach_inflammation0.87764017
125MP0002177_abnormal_outer_ear0.87612312
126MP0000462_abnormal_digestive_system0.86822582
127MP0005367_renal/urinary_system_phenotyp0.85605586
128MP0000516_abnormal_urinary_system0.85605586
129MP0003890_abnormal_embryonic-extraembry0.84469203
130MP0008875_abnormal_xenobiotic_pharmacok0.83555910
131MP0003221_abnormal_cardiomyocyte_apopto0.82765608
132MP0009697_abnormal_copulation0.81899966
133MP0005253_abnormal_eye_physiology0.81816236
134MP0006054_spinal_hemorrhage0.81366587
135MP0000428_abnormal_craniofacial_morphol0.80946451
136MP0008932_abnormal_embryonic_tissue0.80886060
137MP0005408_hypopigmentation0.80488949
138MP0002837_dystrophic_cardiac_calcinosis0.79540985
139MP0009672_abnormal_birth_weight0.79150708
140MP0003943_abnormal_hepatobiliary_system0.78907750
141MP0003119_abnormal_digestive_system0.78850002
142MP0005076_abnormal_cell_differentiation0.78577114
143MP0000432_abnormal_head_morphology0.78427151
144MP0002282_abnormal_trachea_morphology0.77598227
145MP0003567_abnormal_fetal_cardiomyocyte0.77438424
146MP0008873_increased_physiological_sensi0.77320345
147MP0002184_abnormal_innervation0.76880917
148MP0003755_abnormal_palate_morphology0.76843096
149MP0001348_abnormal_lacrimal_gland0.76467898
150MP0005195_abnormal_posterior_eye0.76429891
151MP0005389_reproductive_system_phenotype0.75527208
152MP0000653_abnormal_sex_gland0.75031496
153MP0005410_abnormal_fertilization0.74281964
154MP0005220_abnormal_exocrine_pancreas0.73698861
155MP0003718_maternal_effect0.73205216
156MP0002210_abnormal_sex_determination0.71309713
157MP0000613_abnormal_salivary_gland0.70735823
158MP0009250_abnormal_appendicular_skeleto0.70670394
159MP0001929_abnormal_gametogenesis0.70578545
160MP0001340_abnormal_eyelid_morphology0.70154890
161MP0002932_abnormal_joint_morphology0.68489256
162MP0001145_abnormal_male_reproductive0.68367912
163MP0003936_abnormal_reproductive_system0.68108266
164MP0008961_abnormal_basal_metabolism0.65586837
165MP0005391_vision/eye_phenotype0.64866315

Predicted human phenotypes

RankGene SetZ-score
1Back pain (HP:0003418)6.79089805
2Abnormality of cochlea (HP:0000375)5.12304559
3Cystic liver disease (HP:0006706)4.90198218
4Breast hypoplasia (HP:0003187)4.55576354
5Progressive cerebellar ataxia (HP:0002073)4.34083027
6Volvulus (HP:0002580)4.08495004
7Morphological abnormality of the inner ear (HP:0011390)3.88374699
8Breech presentation (HP:0001623)3.64250894
9Shawl scrotum (HP:0000049)3.56104613
10Hypoplastic labia majora (HP:0000059)3.52290399
11Acute lymphatic leukemia (HP:0006721)3.51954743
12Aplasia/Hypoplasia of the sternum (HP:0006714)3.48239033
13Gastrointestinal atresia (HP:0002589)3.26103275
14Abnormality of the labia majora (HP:0012881)3.22279261
15Chromsome breakage (HP:0040012)3.21691814
16Triphalangeal thumb (HP:0001199)3.15455270
17Prostate neoplasm (HP:0100787)3.09226193
18Facial hemangioma (HP:0000329)3.07544026
19Rhabdomyosarcoma (HP:0002859)2.97776341
20Asplenia (HP:0001746)2.97758197
21Cutaneous finger syndactyly (HP:0010554)2.96437623
22Abnormality of the fingertips (HP:0001211)2.94839665
23Medulloblastoma (HP:0002885)2.94131735
24Lip pit (HP:0100267)2.92950496
25Neoplasm of the oral cavity (HP:0100649)2.85955535
26Fatigue (HP:0012378)2.82152498
27Abnormality of the renal collecting system (HP:0004742)2.80041845
28Selective tooth agenesis (HP:0001592)2.78479202
29Febrile seizures (HP:0002373)2.76952223
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75788421
31Hyperglycinemia (HP:0002154)2.74700020
32Supernumerary spleens (HP:0009799)2.74089286
33Aplasia cutis congenita (HP:0001057)2.73090224
34Abnormality of the duodenum (HP:0002246)2.70996114
35Duplicated collecting system (HP:0000081)2.70671954
36Amaurosis fugax (HP:0100576)2.70464844
37T lymphocytopenia (HP:0005403)2.68219342
38Aplasia/Hypoplasia of the spleen (HP:0010451)2.63462058
39Heterotopia (HP:0002282)2.60689843
40Congenital stationary night blindness (HP:0007642)2.60582780
41Oligodactyly (HP:0012165)2.58737858
42Aplastic anemia (HP:0001915)2.58568473
43Small hand (HP:0200055)2.53043575
44Patellar aplasia (HP:0006443)2.50402787
45Myelodysplasia (HP:0002863)2.50391995
46Cutaneous syndactyly (HP:0012725)2.44814539
47Abnormality of the heme biosynthetic pathway (HP:0010472)2.42758584
48Large earlobe (HP:0009748)2.42525397
49Ectopic kidney (HP:0000086)2.40908741
50Reticulocytopenia (HP:0001896)2.40336683
51Thrombocytosis (HP:0001894)2.39878615
52Abnormality of chromosome stability (HP:0003220)2.37081925
53Abnormality of T cell number (HP:0011839)2.35757326
54Capillary hemangiomas (HP:0005306)2.33436652
55Clitoromegaly (HP:0000057)2.33221162
56Nephroblastoma (Wilms tumor) (HP:0002667)2.33073974
57Gingival bleeding (HP:0000225)2.31245785
58IgM deficiency (HP:0002850)2.30954542
59Aplasia/Hypoplasia of the patella (HP:0006498)2.30223293
60Ependymoma (HP:0002888)2.30128929
61Proximal placement of thumb (HP:0009623)2.29953269
62Neoplasm of striated muscle (HP:0009728)2.29630033
63Periodontitis (HP:0000704)2.26683985
64Microglossia (HP:0000171)2.26021655
65Short palpebral fissure (HP:0012745)2.24092882
66Embryonal renal neoplasm (HP:0011794)2.23761130
67Curly hair (HP:0002212)2.23467876
68Hemivertebrae (HP:0002937)2.23141184
69True hermaphroditism (HP:0010459)2.22658763
70Pustule (HP:0200039)2.18561562
71Rib fusion (HP:0000902)2.17784321
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.17470696
73Short 4th metacarpal (HP:0010044)2.17470696
74Preaxial foot polydactyly (HP:0001841)2.14618476
75Deviation of the thumb (HP:0009603)2.13466719
76Labial hypoplasia (HP:0000066)2.12488398
77Abnormality of DNA repair (HP:0003254)2.09983707
78Cystic hygroma (HP:0000476)2.09608894
79Abnormal number of incisors (HP:0011064)2.09407498
80Bilateral sensorineural hearing impairment (HP:0008619)2.07296315
81Prominent nose (HP:0000448)2.06973250
82Esophageal atresia (HP:0002032)2.06867181
83Methylmalonic acidemia (HP:0002912)2.05908758
84Pancreatic fibrosis (HP:0100732)2.05139148
85Ureteral stenosis (HP:0000071)2.03511533
86Intestinal atresia (HP:0011100)2.02831772
87Supernumerary ribs (HP:0005815)2.02280254
88Birth length less than 3rd percentile (HP:0003561)2.01567302
89Absent frontal sinuses (HP:0002688)1.99361312
90Hypoplastic female external genitalia (HP:0012815)1.98659060
91White forelock (HP:0002211)1.98160541
92Microtia (HP:0008551)1.97492152
93Abnormality of the labia minora (HP:0012880)1.97264343
94Abnormality of the antihelix (HP:0009738)1.96887940
95Recurrent viral infections (HP:0004429)1.95645245
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94237325
97Abnormality of alanine metabolism (HP:0010916)1.94237325
98Hyperalaninemia (HP:0003348)1.94237325
99Abnormality of lateral ventricle (HP:0030047)1.94124061
100Increased nuchal translucency (HP:0010880)1.93423424
101Abnormal lung lobation (HP:0002101)1.93081331
102Pancreatic cysts (HP:0001737)1.93011830
103Premature skin wrinkling (HP:0100678)1.92722055
104Colon cancer (HP:0003003)1.92421512
105Lymphoma (HP:0002665)1.92406930
106Acute myeloid leukemia (HP:0004808)1.92260191
107Long eyelashes (HP:0000527)1.91566866
108Glioma (HP:0009733)1.90947460
109Abnormality of the labia (HP:0000058)1.89704187
110Hemiparesis (HP:0001269)1.88548775
111Abnormal number of erythroid precursors (HP:0012131)1.87912567
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.87647655
113Ureteral obstruction (HP:0006000)1.87289339
114Breast carcinoma (HP:0003002)1.86375698
115Papillary thyroid carcinoma (HP:0002895)1.85743173
116Neoplasm of the adrenal cortex (HP:0100641)1.85670713
117Leukopenia (HP:0001882)1.85150923
118Premature graying of hair (HP:0002216)1.85135212
119Renal dysplasia (HP:0000110)1.85070979
120Lymphopenia (HP:0001888)1.84588597
121Recurrent bacterial skin infections (HP:0005406)1.83851260
122Hypoplasia of the thymus (HP:0000778)1.83770133
123Agnosia (HP:0010524)1.82322816
124Occipital encephalocele (HP:0002085)1.82243039
125Constricted visual fields (HP:0001133)1.81528299
126Abnormality of cells of the lymphoid lineage (HP:0012140)1.81204243
127Supernumerary bones of the axial skeleton (HP:0009144)1.80525144
128Meckel diverticulum (HP:0002245)1.80482376
129Basal cell carcinoma (HP:0002671)1.79831854
130Respiratory distress (HP:0002098)1.79798725
131Postaxial foot polydactyly (HP:0001830)1.78770369
132Broad alveolar ridges (HP:0000187)1.78537993
133Abnormality of the phalanges of the hallux (HP:0010057)1.77858850
134Abnormality of the carotid arteries (HP:0005344)1.76177515
135Sloping forehead (HP:0000340)1.75920648
136Poikiloderma (HP:0001029)1.75456268
137Abnormality of the ileum (HP:0001549)1.73848654
138Abnormality of the prostate (HP:0008775)1.73337587
139Trigonocephaly (HP:0000243)1.73180663
140Neuroblastoma (HP:0003006)1.72579943
141Primitive neuroectodermal tumor (HP:0030065)1.72579943
142Neuroblastic tumors (HP:0004376)1.72579943
143Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.72579943
144Abnormality of cells of the erythroid lineage (HP:0012130)1.72310423
145Bone marrow hypocellularity (HP:0005528)1.70668990
146Tented upper lip vermilion (HP:0010804)1.70464509
147Spontaneous hematomas (HP:0007420)1.69651982
148Abnormality of the 4th metacarpal (HP:0010012)1.69515880
149Recurrent bronchitis (HP:0002837)1.69452499
150Pterygium (HP:0001059)1.69329729
151Deep philtrum (HP:0002002)1.69208104
152Abnormality of T cells (HP:0002843)1.68308571
153Abnormality of the astrocytes (HP:0100707)1.67796365
154Astrocytoma (HP:0009592)1.67796365
155Inflammation of the large intestine (HP:0002037)1.67325453
156IgA deficiency (HP:0002720)1.67282018
157Hyperbilirubinemia (HP:0002904)1.66810433
158Ascites (HP:0001541)1.66490674
159Chronic diarrhea (HP:0002028)1.65581306
160Recurrent abscess formation (HP:0002722)1.62708952
161Aplasia/Hypoplasia of the uvula (HP:0010293)1.62515592
162Premature loss of primary teeth (HP:0006323)1.61599996
163Chronic otitis media (HP:0000389)1.61088886
164Patchy hypopigmentation of hair (HP:0011365)1.59901391
165Clubbing of toes (HP:0100760)1.58149516
166Recurrent skin infections (HP:0001581)1.58095633
167Duodenal stenosis (HP:0100867)1.57740822
168Small intestinal stenosis (HP:0012848)1.57740822
169Depressed nasal tip (HP:0000437)1.57666965
170Abnormality of the preputium (HP:0100587)1.56584297
171Pallor (HP:0000980)1.56307782
172Abnormality of the alveolar ridges (HP:0006477)1.56263099
173Recurrent fungal infections (HP:0002841)1.55873239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.26461817
2BRD44.07388978
3CDK124.00693036
4CDC73.29626927
5SGK22.89962791
6KSR22.61786137
7NEK22.60565504
8KSR12.52703816
9STK162.48034327
10MAP4K12.45786166
11PAK62.40771981
12LATS12.33485278
13FRK2.28667745
14STK38L2.22694219
15STK102.19555111
16WNK32.09681003
17RAF12.00711364
18WNK41.99066696
19BRSK11.93474332
20SGK2231.89747809
21SGK4941.89747809
22TAOK31.84794116
23CCNB11.84724806
24SGK31.81449189
25BMPR21.81421966
26PAK31.75330902
27PBK1.74056670
28STK31.73714594
29BMPR1B1.73604216
30OBSCN1.72812501
31EEF2K1.71378083
32EPHB11.63099761
33PASK1.59834066
34BRSK21.59010700
35RIPK11.51920677
36ACVR1B1.45619671
37ATR1.45360230
38TXK1.42058396
39JAK31.41992516
40STK41.41892899
41EPHB21.41665803
42MKNK11.38912487
43EPHA31.38272931
44CLK11.35493824
45WEE11.35465176
46AKT21.32816933
47TRPM71.32719992
48DYRK31.29914046
49CAMK1D1.25623407
50CDK61.24335972
51TGFBR11.23919679
52CHEK21.21073631
53TTK1.20392607
54KIT1.20314379
55CAMKK21.19781700
56NUAK11.18132381
57CHEK11.17058423
58CDK41.16046819
59CSNK1A1L1.15307962
60MAP3K101.15117384
61CAMK1G1.14874645
62SRPK11.10765653
63RPS6KA41.09707443
64RPS6KB21.09473514
65ATM1.09241724
66TYK21.05837308
67RPS6KA51.02995281
68LCK1.01895175
69BTK1.01818265
70CSF1R0.99525033
71CDK70.98905184
72MAP4K20.98680408
73MKNK20.97787718
74EIF2AK30.93421313
75FGFR20.91936325
76MAP3K140.91851681
77PLK10.91362758
78AURKB0.91311385
79VRK10.89262479
80MELK0.87970113
81FLT30.87044306
82BRAF0.86025377
83MET0.84805119
84NEK10.81507075
85ADRBK20.80398732
86MAP3K40.78497917
87CSK0.77572589
88PNCK0.77361327
89OXSR10.76291567
90CSNK1D0.75814085
91YES10.74814259
92TLK10.73710437
93HCK0.73642911
94MAP3K80.73454985
95TRIM280.72913067
96CDK20.72571239
97PLK40.72427509
98PIM10.70678813
99CDK30.70034239
100VRK20.69822249
101LRRK20.69149573
102TEC0.68614980
103ITK0.67966067
104CDK90.67514834
105BUB10.66814349
106PRKCQ0.64947006
107TAF10.64673185
108HIPK20.63426999
109SCYL20.63029539
110CSNK1G10.62697147
111PLK30.62683322
112SYK0.62107630
113TGFBR20.60793796
114PRKDC0.59704805
115PRKAA10.59061415
116ZAP700.58597535
117CDK10.58412682
118BCR0.58297465
119CSNK1G30.56378120
120MTOR0.55084711
121EIF2AK20.54720966
122MUSK0.53781230
123PDGFRB0.53587721
124LYN0.53207567
125CSNK1G20.53078096
126PTK60.52823082
127SGK10.51203046
128SIK20.51183096
129ZAK0.50935843
130PRKAA20.49988692
131TTN0.49660673
132EGFR0.48987996
133MAP2K10.45411506
134ALK0.45236038
135GRK60.44895281
136PDK20.44874833
137GRK10.44603117
138TSSK60.44490495
139PKN10.43834952
140ERBB30.43260885
141CSNK2A20.43241981
142MAPK140.42916030
143STK390.42704031
144PTK2B0.42563706
145MAPK10.41976151
146AKT10.40514112
147CSNK1E0.38974863
148NLK0.37780865
149PINK10.36195245
150RIPK40.35499098
151MINK10.35342014
152PHKG10.34483432
153PHKG20.34483432
154STK240.34154855
155CAMK10.32811913
156CHUK0.31453725
157PIK3CG0.31174776

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.10810118
2DNA replication_Homo sapiens_hsa030303.92436056
3Propanoate metabolism_Homo sapiens_hsa006402.64335219
4Spliceosome_Homo sapiens_hsa030402.38238745
5Systemic lupus erythematosus_Homo sapiens_hsa053222.35352193
6Cell cycle_Homo sapiens_hsa041102.27527638
7Base excision repair_Homo sapiens_hsa034102.24681625
8One carbon pool by folate_Homo sapiens_hsa006702.23619375
9Homologous recombination_Homo sapiens_hsa034402.15606384
10Nucleotide excision repair_Homo sapiens_hsa034202.12248434
11Fanconi anemia pathway_Homo sapiens_hsa034602.12056610
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06317963
13mRNA surveillance pathway_Homo sapiens_hsa030152.02509039
14RNA transport_Homo sapiens_hsa030131.96532864
15Non-homologous end-joining_Homo sapiens_hsa034501.95069369
16Primary immunodeficiency_Homo sapiens_hsa053401.85756044
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.68949500
18Measles_Homo sapiens_hsa051621.55566066
19Transcriptional misregulation in cancer_Homo sapiens_hsa052021.53859401
20RNA degradation_Homo sapiens_hsa030181.50102454
21Herpes simplex infection_Homo sapiens_hsa051681.49803796
22Lysine degradation_Homo sapiens_hsa003101.49635357
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42698800
24MicroRNAs in cancer_Homo sapiens_hsa052061.39758386
25Viral carcinogenesis_Homo sapiens_hsa052031.38422812
26B cell receptor signaling pathway_Homo sapiens_hsa046621.36558124
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29353233
28Ribosome_Homo sapiens_hsa030101.26974673
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26238980
30Pyruvate metabolism_Homo sapiens_hsa006201.26036203
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.25227599
32Antigen processing and presentation_Homo sapiens_hsa046121.22857349
33Phototransduction_Homo sapiens_hsa047441.19955225
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19872719
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17765130
36Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.17618713
37Notch signaling pathway_Homo sapiens_hsa043301.16772996
38p53 signaling pathway_Homo sapiens_hsa041151.11982947
39HTLV-I infection_Homo sapiens_hsa051661.10005546
40Linoleic acid metabolism_Homo sapiens_hsa005911.09625946
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06496716
42Chronic myeloid leukemia_Homo sapiens_hsa052201.06083848
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05366925
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.00035811
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00024467
46Osteoclast differentiation_Homo sapiens_hsa043800.99256754
47Steroid biosynthesis_Homo sapiens_hsa001000.98936266
48Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97619116
49Small cell lung cancer_Homo sapiens_hsa052220.96849660
50Basal transcription factors_Homo sapiens_hsa030220.96394336
51Hematopoietic cell lineage_Homo sapiens_hsa046400.95473862
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.94064955
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93913375
54Leishmaniasis_Homo sapiens_hsa051400.93026442
55Hedgehog signaling pathway_Homo sapiens_hsa043400.92251630
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92052449
57RNA polymerase_Homo sapiens_hsa030200.91989126
58Hepatitis B_Homo sapiens_hsa051610.90900378
59T cell receptor signaling pathway_Homo sapiens_hsa046600.90604121
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89055542
61Epstein-Barr virus infection_Homo sapiens_hsa051690.87757186
62Alcoholism_Homo sapiens_hsa050340.86334721
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.85704981
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83370983
65Selenocompound metabolism_Homo sapiens_hsa004500.83263776
66Influenza A_Homo sapiens_hsa051640.82330902
67Hepatitis C_Homo sapiens_hsa051600.81757391
68ABC transporters_Homo sapiens_hsa020100.80795020
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80641008
70Pyrimidine metabolism_Homo sapiens_hsa002400.80410870
71Pancreatic cancer_Homo sapiens_hsa052120.79655911
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.79299126
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75673033
74Butanoate metabolism_Homo sapiens_hsa006500.75427941
75Purine metabolism_Homo sapiens_hsa002300.74454244
76Basal cell carcinoma_Homo sapiens_hsa052170.74429262
77Circadian rhythm_Homo sapiens_hsa047100.73886974
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.71521983
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70837238
80Ether lipid metabolism_Homo sapiens_hsa005650.70680274
81Colorectal cancer_Homo sapiens_hsa052100.69558046
82Apoptosis_Homo sapiens_hsa042100.68181735
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.62760493
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61354700
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61245137
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59870003
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58264484
88Viral myocarditis_Homo sapiens_hsa054160.57380480
89Long-term depression_Homo sapiens_hsa047300.56506471
90Non-small cell lung cancer_Homo sapiens_hsa052230.56473883
91Pathways in cancer_Homo sapiens_hsa052000.56323132
92Nitrogen metabolism_Homo sapiens_hsa009100.54948663
93Prostate cancer_Homo sapiens_hsa052150.54705591
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54269440
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53550775
96Tryptophan metabolism_Homo sapiens_hsa003800.53193717
97Chemokine signaling pathway_Homo sapiens_hsa040620.52112712
98Olfactory transduction_Homo sapiens_hsa047400.51056253
99Toxoplasmosis_Homo sapiens_hsa051450.49522676
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48970843
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48906046
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48593783
103Adherens junction_Homo sapiens_hsa045200.48195090
104Caffeine metabolism_Homo sapiens_hsa002320.46946520
105Peroxisome_Homo sapiens_hsa041460.46942383
106Fatty acid degradation_Homo sapiens_hsa000710.46825155
107Inositol phosphate metabolism_Homo sapiens_hsa005620.46675800
108TGF-beta signaling pathway_Homo sapiens_hsa043500.46246258
109Malaria_Homo sapiens_hsa051440.46094394
110Platelet activation_Homo sapiens_hsa046110.45682593
111Acute myeloid leukemia_Homo sapiens_hsa052210.44492041
112Retinol metabolism_Homo sapiens_hsa008300.43984045
113Proteasome_Homo sapiens_hsa030500.43978141
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41491061
115Wnt signaling pathway_Homo sapiens_hsa043100.41099044
116mTOR signaling pathway_Homo sapiens_hsa041500.40849341
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39866383
118Fatty acid elongation_Homo sapiens_hsa000620.39478350
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39370928
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39366727
121beta-Alanine metabolism_Homo sapiens_hsa004100.39078880
122Proteoglycans in cancer_Homo sapiens_hsa052050.38624996
123Protein export_Homo sapiens_hsa030600.38424121
124FoxO signaling pathway_Homo sapiens_hsa040680.37952020
125Chemical carcinogenesis_Homo sapiens_hsa052040.36931548
126Asthma_Homo sapiens_hsa053100.36410619
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36069575
128Oocyte meiosis_Homo sapiens_hsa041140.35675684
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34221625
130Oxidative phosphorylation_Homo sapiens_hsa001900.34041461
131Legionellosis_Homo sapiens_hsa051340.33137938
132Fat digestion and absorption_Homo sapiens_hsa049750.31871232
133TNF signaling pathway_Homo sapiens_hsa046680.30906067
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30733046
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.29904436
136Metabolic pathways_Homo sapiens_hsa011000.29897926
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.27301822
138Huntingtons disease_Homo sapiens_hsa050160.27102190
139Melanogenesis_Homo sapiens_hsa049160.23559987
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22074140
141Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.21991383
142Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20975048
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.20895565
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20355985
145Fatty acid metabolism_Homo sapiens_hsa012120.20333887
146Histidine metabolism_Homo sapiens_hsa003400.20324710
147Fatty acid biosynthesis_Homo sapiens_hsa000610.19911723
148Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.19654330
149Arachidonic acid metabolism_Homo sapiens_hsa005900.19624073
150Folate biosynthesis_Homo sapiens_hsa007900.19450813
151Circadian entrainment_Homo sapiens_hsa047130.18546481
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17782330
153Parkinsons disease_Homo sapiens_hsa050120.17630503
154Salivary secretion_Homo sapiens_hsa049700.17618533
155Drug metabolism - other enzymes_Homo sapiens_hsa009830.15907322
156Starch and sucrose metabolism_Homo sapiens_hsa005000.15789829
157Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14248531

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »