GCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.88382614
2translational termination (GO:0006415)8.47697391
3ribosomal small subunit biogenesis (GO:0042274)7.15274807
4translational elongation (GO:0006414)6.83467649
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.72754213
6cotranslational protein targeting to membrane (GO:0006613)6.72240383
7protein targeting to ER (GO:0045047)6.71554634
8viral life cycle (GO:0019058)6.61261937
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.44946537
10establishment of protein localization to mitochondrial membrane (GO:0090151)6.43735963
11cellular protein complex disassembly (GO:0043624)6.43380116
12maturation of SSU-rRNA (GO:0030490)6.20888666
13protein localization to endoplasmic reticulum (GO:0070972)6.18061877
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.18061293
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00408385
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.52228965
17ATP synthesis coupled proton transport (GO:0015986)5.52228965
18protein complex disassembly (GO:0043241)5.49586127
19translational initiation (GO:0006413)5.26201343
20ribosomal small subunit assembly (GO:0000028)5.17779000
21macromolecular complex disassembly (GO:0032984)5.14589467
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.86333978
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.86333978
24sequestering of actin monomers (GO:0042989)4.79906866
25protein targeting to membrane (GO:0006612)4.62740619
26chaperone-mediated protein transport (GO:0072321)4.46952874
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.31958919
28NADH dehydrogenase complex assembly (GO:0010257)4.31958919
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31958919
30antigen processing and presentation of endogenous antigen (GO:0019883)4.28626624
31nuclear-transcribed mRNA catabolic process (GO:0000956)4.19125821
32mRNA catabolic process (GO:0006402)4.04373857
33protein complex biogenesis (GO:0070271)4.00692582
34endothelial cell chemotaxis (GO:0035767)4.00602928
35respiratory electron transport chain (GO:0022904)3.98378448
36electron transport chain (GO:0022900)3.92061180
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.86269142
38positive regulation of p38MAPK cascade (GO:1900745)3.83958732
39regulation of gamma-delta T cell differentiation (GO:0045586)3.83047801
40regulation of interleukin-12 biosynthetic process (GO:0045075)3.79983590
41behavioral response to nicotine (GO:0035095)3.76578367
42translation (GO:0006412)3.72655152
43viral protein processing (GO:0019082)3.71578978
44RNA catabolic process (GO:0006401)3.69638576
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69125906
46growth hormone receptor signaling pathway (GO:0060396)3.65235788
47JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.65040589
48positive regulation of gastrulation (GO:2000543)3.60196140
49mitochondrial respiratory chain complex assembly (GO:0033108)3.58772942
50regulation of cholesterol homeostasis (GO:2000188)3.52296681
51peptidyl-glutamic acid carboxylation (GO:0017187)3.45472416
52protein carboxylation (GO:0018214)3.45472416
53ribosomal large subunit biogenesis (GO:0042273)3.45297470
54positive thymic T cell selection (GO:0045059)3.40586755
55protein localization to endosome (GO:0036010)3.39036379
56regulation of gamma-delta T cell activation (GO:0046643)3.38582013
57inner mitochondrial membrane organization (GO:0007007)3.37687544
58pyrimidine nucleobase catabolic process (GO:0006208)3.37500947
59establishment of protein localization to membrane (GO:0090150)3.32275761
60cell migration involved in sprouting angiogenesis (GO:0002042)3.27753990
61positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.27316200
62protein neddylation (GO:0045116)3.26435937
63regulation of p38MAPK cascade (GO:1900744)3.18606921
64positive regulation of gamma-delta T cell activation (GO:0046645)3.18223820
65positive regulation of histone deacetylation (GO:0031065)3.10934901
66apoptotic cell clearance (GO:0043277)3.10801160
67hindbrain development (GO:0030902)3.07412771
68cellular response to growth hormone stimulus (GO:0071378)3.05637235
69positive regulation of protein homooligomerization (GO:0032464)3.04495788
70negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.99718469
71alpha-linolenic acid metabolic process (GO:0036109)2.98342044
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95411492
73single strand break repair (GO:0000012)2.95305761
74adaptation of signaling pathway (GO:0023058)2.95303567
75regulation of feeding behavior (GO:0060259)2.94119617
76* protein targeting (GO:0006605)2.91143930
77water-soluble vitamin biosynthetic process (GO:0042364)2.90328572
78positive regulation of T cell apoptotic process (GO:0070234)2.89104570
79negative regulation of fibrinolysis (GO:0051918)2.88366380
80positive regulation of fatty acid beta-oxidation (GO:0032000)2.87927960
81pyrimidine nucleotide catabolic process (GO:0006244)2.87739279
82cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.87335371
83specification of organ identity (GO:0010092)2.85169469
84ribonucleoprotein complex biogenesis (GO:0022613)2.84525364
85* establishment of protein localization to organelle (GO:0072594)2.83506799
86blood vessel endothelial cell migration (GO:0043534)2.83469041
87RNA destabilization (GO:0050779)2.82972796
88cellular component biogenesis (GO:0044085)2.82859272
89termination of RNA polymerase III transcription (GO:0006386)2.81304826
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.81304826
91regulation of fibrinolysis (GO:0051917)2.79699237
92complement activation, alternative pathway (GO:0006957)2.79676250
93negative regulation of cell killing (GO:0031342)2.78973490
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78973490
95regulation of chromatin binding (GO:0035561)2.78868550
96COPI coating of Golgi vesicle (GO:0048205)2.77198259
97Golgi transport vesicle coating (GO:0048200)2.77198259
98activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.76397512
99positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.76163568
100negative regulation of response to food (GO:0032096)2.76088385
101negative regulation of appetite (GO:0032099)2.76088385
102neuron fate determination (GO:0048664)2.73789428
103intracellular protein transmembrane import (GO:0044743)2.72187911
104ventricular trabecula myocardium morphogenesis (GO:0003222)2.71960873
105low-density lipoprotein particle clearance (GO:0034383)2.68478544
106hydrogen ion transmembrane transport (GO:1902600)2.68453193
107mitochondrion distribution (GO:0048311)2.68291852
108regulation of interferon-gamma biosynthetic process (GO:0045072)2.67513169
109response to type I interferon (GO:0034340)2.67013631
110positive regulation of glycolytic process (GO:0045821)2.64562712
111ATP biosynthetic process (GO:0006754)2.64262819
112L-phenylalanine catabolic process (GO:0006559)2.63903474
113erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.63903474
114positive T cell selection (GO:0043368)2.63629329
115cell proliferation in forebrain (GO:0021846)2.61148429
116regulation of protein activation cascade (GO:2000257)2.61052862
117modulation by symbiont of host immune response (GO:0052553)2.60181564
118positive regulation by symbiont of host defense response (GO:0052509)2.60181564
119modulation by symbiont of host defense response (GO:0052031)2.60181564
120modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60181564
121modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60181564
122positive regulation by organism of defense response of other organism involved in symbiotic interact2.60181564
123L-phenylalanine metabolic process (GO:0006558)2.59404549
124erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.59404549
125positive regulation of nuclease activity (GO:0032075)2.58935522
126type I interferon signaling pathway (GO:0060337)2.57797154
127cellular response to type I interferon (GO:0071357)2.57797154
128thymic T cell selection (GO:0045061)2.57601040
129negative regulation of sterol transport (GO:0032372)2.57353502
130negative regulation of cholesterol transport (GO:0032375)2.57353502
131spliceosomal complex assembly (GO:0000245)2.56338566
132negative regulation of DNA-templated transcription, elongation (GO:0032785)2.56268973
133positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.55684445
134regulation of interferon-beta biosynthetic process (GO:0045357)2.53095114
135mitochondrion morphogenesis (GO:0070584)2.53010466
136regulation of complement activation (GO:0030449)2.52007905
137positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51979984
138positive regulation of natural killer cell differentiation (GO:0032825)2.50500052
139dopaminergic neuron differentiation (GO:0071542)2.49162671
140protein localization to membrane (GO:0072657)2.48681941
141COPII vesicle coating (GO:0048208)2.46806022
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.46610101
143tolerance induction (GO:0002507)2.46207360
144regulation of fatty acid beta-oxidation (GO:0031998)2.44667837
145histone H3-K4 trimethylation (GO:0080182)2.44069235
146valine metabolic process (GO:0006573)2.43726867
147endoplasmic reticulum unfolded protein response (GO:0030968)2.43292675
148establishment of protein localization to mitochondrion (GO:0072655)2.42829090
149virion assembly (GO:0019068)2.42630680
150spliceosomal snRNP assembly (GO:0000387)2.42502757
151regulation of cholesterol storage (GO:0010885)2.42322909
152positive regulation of response to oxidative stress (GO:1902884)2.42020599
153positive regulation of cellular response to oxidative stress (GO:1900409)2.42020599
154spinal cord motor neuron differentiation (GO:0021522)2.41511235
155negative regulation of lipid transport (GO:0032369)2.41498857
156fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.41015468
157regulation of extracellular matrix disassembly (GO:0010715)2.40640513
158hormone catabolic process (GO:0042447)2.40349936
159triglyceride homeostasis (GO:0070328)2.39283904
160acylglycerol homeostasis (GO:0055090)2.39283904
161regulation of triglyceride biosynthetic process (GO:0010866)2.37389391
162regulation of microtubule-based movement (GO:0060632)2.36630920
163regulation of monocyte differentiation (GO:0045655)2.35574303
164receptor catabolic process (GO:0032801)2.35420173
165positive regulation of RNA splicing (GO:0033120)2.34950516
166regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.34851362
167synaptic transmission, dopaminergic (GO:0001963)2.34677233
168ER-nucleus signaling pathway (GO:0006984)2.34633052
169regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32138793
170sulfur amino acid catabolic process (GO:0000098)2.32132935
171regulation of nuclease activity (GO:0032069)2.31968935
172cellular response to unfolded protein (GO:0034620)2.31771030
173positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.31010167
174high-density lipoprotein particle remodeling (GO:0034375)2.30833608
175urea metabolic process (GO:0019627)2.29937829
176urea cycle (GO:0000050)2.29937829
177response to laminar fluid shear stress (GO:0034616)2.29929836
178JAK-STAT cascade (GO:0007259)2.29768145
179plasma lipoprotein particle clearance (GO:0034381)2.29536520
180cytoplasmic mRNA processing body assembly (GO:0033962)2.28707377
181regulation of membrane protein ectodomain proteolysis (GO:0051043)2.28122899
182mannose metabolic process (GO:0006013)2.26760554
183macroautophagy (GO:0016236)2.26458063
184maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.25745733
185negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.25627670
186reverse cholesterol transport (GO:0043691)2.24756927
187regulation of type I interferon-mediated signaling pathway (GO:0060338)2.24639928
188positive regulation of triglyceride biosynthetic process (GO:0010867)2.24453799
189positive regulation of lipid catabolic process (GO:0050996)2.23463724
190vascular endothelial growth factor signaling pathway (GO:0038084)2.23210445
191L-alpha-amino acid transmembrane transport (GO:1902475)2.23117727
192T cell selection (GO:0045058)2.22065221
193intestinal cholesterol absorption (GO:0030299)2.21874518
194positive regulation of fatty acid biosynthetic process (GO:0045723)2.20418009
195aromatic amino acid family catabolic process (GO:0009074)2.20255098
196response to nitrosative stress (GO:0051409)2.19724182
197response to muramyl dipeptide (GO:0032495)2.18825363
198insulin-like growth factor receptor signaling pathway (GO:0048009)2.17475266
199positive regulation of glycogen biosynthetic process (GO:0045725)2.15269238
200regulation of T cell tolerance induction (GO:0002664)2.14218091

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.55276918
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.21624162
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.88343814
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.70568872
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.60981925
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.43582069
7EZH2_22144423_ChIP-Seq_EOC_Human3.40502553
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.38736611
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.24680574
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.07706449
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.05967439
12* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse3.03552042
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.01146618
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.99005921
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98985611
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.90481362
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.86430064
18CLOCK_20551151_ChIP-Seq_293T_Human2.73965247
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.67343090
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.65090981
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.62112736
22XRN2_22483619_ChIP-Seq_HELA_Human2.45449660
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.44191303
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.41212259
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.40771062
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33813969
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.32936116
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26379492
29TRIM28_21343339_ChIP-Seq_HEK293_Human2.25750089
30TP63_17297297_ChIP-ChIP_HaCaT_Human2.25430635
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24101239
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23186370
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12676815
34TTF2_22483619_ChIP-Seq_HELA_Human1.98592783
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98525368
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.98003432
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97328968
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93458025
39FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83580906
40TCF7_22412390_ChIP-Seq_EML_Mouse1.82859695
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81782908
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.81744714
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.79114438
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78164146
45KDM2B_26808549_Chip-Seq_DND41_Human1.76817832
46FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.76139287
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73549465
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.70929210
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.69858995
50TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68697524
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65968361
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65799012
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63719214
54KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63648171
55RUNX_20019798_ChIP-Seq_JUKART_Human1.61518618
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.59906788
57MYC_22102868_ChIP-Seq_BL_Human1.59160864
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.58487105
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.58433156
60* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.55641850
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55494592
62NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54480994
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53978402
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.51530576
65MAF_26560356_Chip-Seq_TH1_Human1.49909149
66RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.49882157
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49749476
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.48731880
69* ERG_21242973_ChIP-ChIP_JURKAT_Human1.48553775
70VDR_23849224_ChIP-Seq_CD4+_Human1.47716374
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47135369
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46627978
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46520089
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44316621
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43712243
76FOXP3_21729870_ChIP-Seq_TREG_Human1.38823646
77SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38803187
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.38516622
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37601975
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.34170076
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34003405
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.33963606
83GABP_19822575_ChIP-Seq_HepG2_Human1.32413614
84* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31730207
85MAF_26560356_Chip-Seq_TH2_Human1.31692531
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.31358926
87IRF8_27001747_Chip-Seq_BMDM_Mouse1.30923883
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30917345
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.30839515
90GATA1_22025678_ChIP-Seq_K562_Human1.29511917
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28595873
92TET1_21451524_ChIP-Seq_MESCs_Mouse1.28415263
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.28381398
94* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.28044741
95ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27778484
96BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27339786
97JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26353100
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.25678601
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25480774
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24556057
101RACK7_27058665_Chip-Seq_MCF-7_Human1.24434639
102KDM5A_27292631_Chip-Seq_BREAST_Human1.23466186
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23258946
104NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23045854
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22324384
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22247076
107KDM2B_26808549_Chip-Seq_K562_Human1.22238419
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21854375
109GATA1_19941826_ChIP-Seq_K562_Human1.21597989
110SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21557752
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20464123
112EZH2_27294783_Chip-Seq_ESCs_Mouse1.20079439
113E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19184446
114LXR_22292898_ChIP-Seq_THP-1_Human1.18998307
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.18176696
116Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17657428
117MYB_26560356_Chip-Seq_TH2_Human1.17427320
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17026119
119P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17017482
120UTX_26944678_Chip-Seq_JUKART_Human1.16914668
121ZNF263_19887448_ChIP-Seq_K562_Human1.15756394
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15743355
123MYB_26560356_Chip-Seq_TH1_Human1.15476934
124SA1_27219007_Chip-Seq_ERYTHROID_Human1.15014855
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14153717
126VDR_21846776_ChIP-Seq_THP-1_Human1.13709145
127KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13660361
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13390624
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12296785
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10562635
131JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10004106
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09581013
133SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08778527
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08332117
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07563536
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07002601
137KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05366500
138KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05366500
139KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05366500
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05232230
141VDR_24763502_ChIP-Seq_THP-1_Human1.04087241
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03418787
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02726372
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02534034
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02504244
146TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02400472
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02230701
148FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02029900
149MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01612812
150SOX2_16153702_ChIP-ChIP_HESCs_Human1.01250244
151* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01176465
152IRF1_19129219_ChIP-ChIP_H3396_Human1.01118310
153FOXP1_21924763_ChIP-Seq_HESCs_Human1.01083479
154CREB1_26743006_Chip-Seq_LNCaP_Human1.00694265
155CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00578364
156STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99980718
157ELK1_19687146_ChIP-ChIP_HELA_Human0.99962823
158SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.99666922
159* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99387166
160* BCL6_27268052_Chip-Seq_Bcells_Human0.99168544
161NCOR1_26117541_ChIP-Seq_K562_Human0.98813292
162MYC_18940864_ChIP-ChIP_HL60_Human0.98680634
163GATA2_19941826_ChIP-Seq_K562_Human0.98649499
164CTCF_21964334_Chip-Seq_Bcells_Human0.98577132
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98377250
166DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98320442
167FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97869091
168DCP1A_22483619_ChIP-Seq_HELA_Human0.97454862
169POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97126645
170DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97029175
171STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96855970
172TBX20_22328084_ChIP-Seq_HEART_Mouse0.96838508
173TBX20_22080862_ChIP-Seq_HEART_Mouse0.96838508
174TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96633489
175EED_16625203_ChIP-ChIP_MESCs_Mouse0.96371941
176ATF3_27146783_Chip-Seq_COLON_Human0.95538942
177SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94799201
178ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94769693
179VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94602063
180GATA3_27048872_Chip-Seq_THYMUS_Human0.94191010
181CJUN_26792858_Chip-Seq_BT549_Human0.94093494
182SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93713687
183SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93713687
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.93483382
185IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.93153389
186CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88798068
187CTCF_26484167_Chip-Seq_Bcells_Mouse0.88483006
188RNF2_27304074_Chip-Seq_ESCs_Mouse0.85922470

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.93289831
2MP0006292_abnormal_olfactory_placode4.11642609
3MP0003300_gastrointestinal_ulcer3.86995259
4MP0002277_abnormal_respiratory_mucosa3.65367791
5MP0002139_abnormal_hepatobiliary_system3.57964115
6MP0003303_peritoneal_inflammation3.36475179
7MP0002653_abnormal_ependyma_morphology3.30514654
8MP0003705_abnormal_hypodermis_morpholog2.94024646
9MP0005365_abnormal_bile_salt2.83087504
10MP0005360_urolithiasis2.76955254
11MP0003252_abnormal_bile_duct2.74848992
12MP0008438_abnormal_cutaneous_collagen2.71787091
13MP0003045_fibrosis2.46112228
14MP0005085_abnormal_gallbladder_physiolo2.33634878
15MP0001293_anophthalmia2.30271845
16MP0002166_altered_tumor_susceptibility2.27543516
17MP0004510_myositis2.18099535
18MP0003724_increased_susceptibility_to2.14171658
19MP0010030_abnormal_orbit_morphology2.09283648
20MP0004142_abnormal_muscle_tone2.06432385
21MP0000049_abnormal_middle_ear2.00913877
22MP0002877_abnormal_melanocyte_morpholog1.98304738
23MP0008875_abnormal_xenobiotic_pharmacok1.92559645
24MP0001905_abnormal_dopamine_level1.92193168
25MP0003011_delayed_dark_adaptation1.71972914
26MP0004947_skin_inflammation1.66967760
27MP0005275_abnormal_skin_tensile1.66459960
28MP0004133_heterotaxia1.64805442
29MP0009780_abnormal_chondrocyte_physiolo1.64423329
30MP0008961_abnormal_basal_metabolism1.63710984
31MP0000685_abnormal_immune_system1.63529762
32MP0002138_abnormal_hepatobiliary_system1.62962387
33MP0003436_decreased_susceptibility_to1.62257248
34MP0002254_reproductive_system_inflammat1.61345035
35MP0003123_paternal_imprinting1.61250181
36MP0002006_tumorigenesis1.61110726
37MP0010234_abnormal_vibrissa_follicle1.59069931
38MP0010329_abnormal_lipoprotein_level1.57943952
39MP0000778_abnormal_nervous_system1.57680822
40MP0010352_gastrointestinal_tract_polyps1.57490356
41MP0000609_abnormal_liver_physiology1.56987532
42MP0003195_calcinosis1.53840950
43MP0003191_abnormal_cellular_cholesterol1.53009890
44MP0001790_abnormal_immune_system1.52431135
45MP0005387_immune_system_phenotype1.52431135
46MP0005423_abnormal_somatic_nervous1.52307305
47MP0004742_abnormal_vestibular_system1.51294464
48MP0003566_abnormal_cell_adhesion1.51082976
49MP0003136_yellow_coat_color1.50613574
50MP0009278_abnormal_bone_marrow1.49540869
51MP0001529_abnormal_vocalization1.47001465
52MP0002822_catalepsy1.46536648
53MP0008789_abnormal_olfactory_epithelium1.46064574
54MP0009840_abnormal_foam_cell1.45634397
55MP0005499_abnormal_olfactory_system1.45438872
56MP0005394_taste/olfaction_phenotype1.45438872
57MP0000566_synostosis1.44006699
58MP0005023_abnormal_wound_healing1.43276591
59MP0003315_abnormal_perineum_morphology1.42821380
60MP0003938_abnormal_ear_development1.41372885
61MP0001919_abnormal_reproductive_system1.41362044
62MP0003121_genomic_imprinting1.41146921
63MP0002092_abnormal_eye_morphology1.40095164
64MP0003763_abnormal_thymus_physiology1.38505034
65MP0005076_abnormal_cell_differentiation1.38423347
66MP0000955_abnormal_spinal_cord1.37446615
67MP0001533_abnormal_skeleton_physiology1.34234505
68MP0003866_abnormal_defecation1.32955042
69MP0005671_abnormal_response_to1.31627638
70MP0004885_abnormal_endolymph1.30008270
71MP0000631_abnormal_neuroendocrine_gland1.29202210
72MP0005083_abnormal_biliary_tract1.28987072
73MP0004808_abnormal_hematopoietic_stem1.27561348
74MP0002168_other_aberrant_phenotype1.26713705
75MP0002234_abnormal_pharynx_morphology1.24962484
76MP0006082_CNS_inflammation1.24438220
77MP0003787_abnormal_imprinting1.24223671
78MP0003890_abnormal_embryonic-extraembry1.21510847
79MP0001666_abnormal_nutrient_absorption1.21051462
80MP0009333_abnormal_splenocyte_physiolog1.20304965
81MP0003091_abnormal_cell_migration1.19980600
82MP0009053_abnormal_anal_canal1.19682293
83MP0004130_abnormal_muscle_cell1.19181852
84MP0001286_abnormal_eye_development1.18688460
85MP0003693_abnormal_embryo_hatching1.17814545
86MP0001851_eye_inflammation1.16572881
87MP0004185_abnormal_adipocyte_glucose1.16339534
88MP0003868_abnormal_feces_composition1.13670121
89MP0001879_abnormal_lymphatic_vessel1.12645971
90MP0005084_abnormal_gallbladder_morpholo1.12261286
91MP0001324_abnormal_eye_pigmentation1.11777823
92MP0001853_heart_inflammation1.11602102
93MP0010155_abnormal_intestine_physiology1.11383793
94MP0001485_abnormal_pinna_reflex1.11113284
95MP0005000_abnormal_immune_tolerance1.09714419
96MP0002998_abnormal_bone_remodeling1.09225812
97MP0009764_decreased_sensitivity_to1.09101315
98MP0000569_abnormal_digit_pigmentation1.08773771
99MP0010368_abnormal_lymphatic_system1.08328158
100MP0005220_abnormal_exocrine_pancreas1.07072888
101MP0001800_abnormal_humoral_immune1.06063716
102MP0005058_abnormal_lysosome_morphology1.05962741
103MP0002060_abnormal_skin_morphology1.05457361
104MP0005375_adipose_tissue_phenotype1.03988987
105MP0002928_abnormal_bile_duct1.02518831
106MP0002896_abnormal_bone_mineralization1.02224376
107MP0000003_abnormal_adipose_tissue1.01055326
108MP0003186_abnormal_redox_activity1.00929011
109MP0006054_spinal_hemorrhage0.99689969
110MP0000026_abnormal_inner_ear0.99367551
111MP0005464_abnormal_platelet_physiology0.99282634
112MP0001845_abnormal_inflammatory_respons0.98997013
113MP0004272_abnormal_basement_membrane0.98701706
114MP0002723_abnormal_immune_serum0.97896296
115MP0009643_abnormal_urine_homeostasis0.97744341
116MP0005666_abnormal_adipose_tissue0.97700397
117MP0002697_abnormal_eye_size0.97629629
118MP0002118_abnormal_lipid_homeostasis0.97528771
119MP0000733_abnormal_muscle_development0.96407428
120MP0000604_amyloidosis0.96388124
121MP0004264_abnormal_extraembryonic_tissu0.96162179
122MP0002638_abnormal_pupillary_reflex0.95506993
123MP0003279_aneurysm0.94959827
124MP0001243_abnormal_dermal_layer0.94492353
125MP0001188_hyperpigmentation0.93638369
126MP0003075_altered_response_to0.93069935
127MP0005319_abnormal_enzyme/_coenzyme0.92875366
128MP0002095_abnormal_skin_pigmentation0.92721637
129MP0003828_pulmonary_edema0.91136223
130MP0005310_abnormal_salivary_gland0.90178742
131MP0008469_abnormal_protein_level0.89917641
132MP0002452_abnormal_antigen_presenting0.89752504
133MP0008004_abnormal_stomach_pH0.89255416
134MP0003453_abnormal_keratinocyte_physiol0.88166778
135MP0001186_pigmentation_phenotype0.87868298
136MP0000598_abnormal_liver_morphology0.86907495
137MP0002419_abnormal_innate_immunity0.86506379
138MP0003755_abnormal_palate_morphology0.86011320
139MP0010307_abnormal_tumor_latency0.85478179
140MP0002752_abnormal_somatic_nervous0.85155860
141MP0001849_ear_inflammation0.85029728
142MP0002405_respiratory_system_inflammati0.84812424
143MP0005025_abnormal_response_to0.83133368
144MP0005195_abnormal_posterior_eye0.83016322
145MP0002933_joint_inflammation0.82797693
146MP0000249_abnormal_blood_vessel0.82675231
147MP0009763_increased_sensitivity_to0.81933989
148MP0003878_abnormal_ear_physiology0.81226255
149MP0005377_hearing/vestibular/ear_phenot0.81226255
150MP0001835_abnormal_antigen_presentation0.80984415
151MP0006035_abnormal_mitochondrial_morpho0.79994712
152MP0003172_abnormal_lysosome_physiology0.79908146
153MP0009785_altered_susceptibility_to0.78624787
154MP0002420_abnormal_adaptive_immunity0.78296956
155MP0005391_vision/eye_phenotype0.78294746
156MP0005164_abnormal_response_to0.77560743
157MP0000470_abnormal_stomach_morphology0.77551161
158MP0003879_abnormal_hair_cell0.77104141
159MP0001819_abnormal_immune_cell0.77059103
160MP0001944_abnormal_pancreas_morphology0.76626606
161MP0000371_diluted_coat_color0.76288803
162MP0000490_abnormal_crypts_of0.75110478
163MP0002233_abnormal_nose_morphology0.74662129
164MP0001663_abnormal_digestive_system0.73965272
165MP0000750_abnormal_muscle_regeneration0.73859876
166MP0002152_abnormal_brain_morphology0.73769741
167MP0002210_abnormal_sex_determination0.73255645
168MP0000537_abnormal_urethra_morphology0.72242194
169MP0005381_digestive/alimentary_phenotyp0.72131346
170MP0003861_abnormal_nervous_system0.71956218
171MP0003942_abnormal_urinary_system0.71062695
172MP0002177_abnormal_outer_ear0.70566226
173MP0002148_abnormal_hypersensitivity_rea0.69061992
174MP0005410_abnormal_fertilization0.68561774
175MP0001440_abnormal_grooming_behavior0.68490649
176MP0003122_maternal_imprinting0.67615142
177MP0009250_abnormal_appendicular_skeleto0.67441207
178MP0009765_abnormal_xenobiotic_induced0.65758887

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.38302949
2Abnormal number of erythroid precursors (HP:0012131)7.12656856
3Reticulocytopenia (HP:0001896)5.22208947
4Macrocytic anemia (HP:0001972)4.79687245
5Pallor (HP:0000980)4.61663959
6Renal Fanconi syndrome (HP:0001994)4.36133501
7Increased hepatocellular lipid droplets (HP:0006565)4.02654313
8Abnormal number of incisors (HP:0011064)3.94110556
9Deep venous thrombosis (HP:0002625)3.89859019
10Myocardial infarction (HP:0001658)3.74902326
11Lipid accumulation in hepatocytes (HP:0006561)3.50391951
12Cerebral aneurysm (HP:0004944)3.49472851
13Septo-optic dysplasia (HP:0100842)3.42942823
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.40327486
15Acute necrotizing encephalopathy (HP:0006965)3.35543238
16Mitochondrial inheritance (HP:0001427)3.31234524
17Abnormality of renal resorption (HP:0011038)3.26537919
18Exertional dyspnea (HP:0002875)3.23501054
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15420752
20Abnormality of the common coagulation pathway (HP:0010990)3.10316915
21Xanthomatosis (HP:0000991)3.08991791
22Abnormality of the nasal mucosa (HP:0000433)3.08461161
23Abnormal mitochondria in muscle tissue (HP:0008316)3.06998723
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.04730111
25Aortic aneurysm (HP:0004942)2.98386306
26Protrusio acetabuli (HP:0003179)2.96532335
27Increased connective tissue (HP:0009025)2.96158270
28Nasal polyposis (HP:0100582)2.95374658
29Mitral valve prolapse (HP:0001634)2.94643919
303-Methylglutaconic aciduria (HP:0003535)2.93262894
31Increased intramyocellular lipid droplets (HP:0012240)2.93160662
32Peritonitis (HP:0002586)2.83949375
33Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82655344
34Complement deficiency (HP:0004431)2.82296315
35Congenital, generalized hypertrichosis (HP:0004540)2.81790770
36Maternal diabetes (HP:0009800)2.80586743
37Respiratory difficulties (HP:0002880)2.78542471
38Intrahepatic cholestasis (HP:0001406)2.76760340
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.76680749
40Recurrent bacterial skin infections (HP:0005406)2.72688694
41Aneurysm (HP:0002617)2.64428624
42Progressive macrocephaly (HP:0004481)2.63305469
43Increased CSF lactate (HP:0002490)2.61545297
44Mitral stenosis (HP:0001718)2.61011965
45Polycythemia (HP:0001901)2.60891437
46Premature rupture of membranes (HP:0001788)2.57884237
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56275430
48Esophageal varix (HP:0002040)2.54661551
49Increased CSF protein (HP:0002922)2.53171504
50Aortic dissection (HP:0002647)2.49806107
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49461691
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49461691
53Striae distensae (HP:0001065)2.48568957
54Prolonged partial thromboplastin time (HP:0003645)2.47854437
55Parakeratosis (HP:0001036)2.42986888
56Autoimmune thrombocytopenia (HP:0001973)2.42558188
57Acute encephalopathy (HP:0006846)2.42503331
58Chronic otitis media (HP:0000389)2.42286325
59Abnormality of the parietal bone (HP:0002696)2.41679143
60Increased muscle lipid content (HP:0009058)2.38926536
61Abnormality of the intrinsic pathway (HP:0010989)2.38291397
62Broad metatarsal (HP:0001783)2.34629474
63Dilatation of the ascending aorta (HP:0005111)2.33980602
64Spontaneous hematomas (HP:0007420)2.32732876
6511 pairs of ribs (HP:0000878)2.31461232
66Hemorrhage of the eye (HP:0011885)2.30351434
67Absent septum pellucidum (HP:0001331)2.29812674
68Rib fusion (HP:0000902)2.28434127
69Joint hemorrhage (HP:0005261)2.27718951
70Limb dystonia (HP:0002451)2.27709191
71Recurrent bronchitis (HP:0002837)2.25690478
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23168999
73Chronic hepatic failure (HP:0100626)2.22594959
74Esotropia (HP:0000565)2.22230254
75Disproportionate tall stature (HP:0001519)2.20778848
76Congenital stationary night blindness (HP:0007642)2.20235560
77Sclerocornea (HP:0000647)2.18860212
78Myokymia (HP:0002411)2.18817818
79Abnormality of the septum pellucidum (HP:0007375)2.15993920
80Acute lymphatic leukemia (HP:0006721)2.15284538
81Severe visual impairment (HP:0001141)2.15181142
82Abnormality of reticulocytes (HP:0004312)2.14705181
83Urinary glycosaminoglycan excretion (HP:0003541)2.14523195
84Mucopolysacchariduria (HP:0008155)2.14523195
85Hypogonadotrophic hypogonadism (HP:0000044)2.13606173
86Atrophic scars (HP:0001075)2.13432558
87Concave nail (HP:0001598)2.12373822
88Oral leukoplakia (HP:0002745)2.11920014
89Supernumerary bones of the axial skeleton (HP:0009144)2.11452287
90Renal tubular dysfunction (HP:0000124)2.11203790
91Abnormality of complement system (HP:0005339)2.10380409
92Hematochezia (HP:0002573)2.10115644
93Woolly hair (HP:0002224)2.07795016
94Hyperlipoproteinemia (HP:0010980)2.07462305
95Gingival bleeding (HP:0000225)2.06464783
96Epidermoid cyst (HP:0200040)2.05848615
97Dysostosis multiplex (HP:0000943)2.05110772
98Pendular nystagmus (HP:0012043)2.03852449
99Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03684676
100Shallow orbits (HP:0000586)2.03663799
101Abnormal rod and cone electroretinograms (HP:0008323)2.01390416
102Spondylolisthesis (HP:0003302)2.00702647
103Colitis (HP:0002583)2.00565029
104Ectopia lentis (HP:0001083)1.99158782
105Abnormality of T cell number (HP:0011839)1.99073969
106Eczematoid dermatitis (HP:0000976)1.99050571
107Supernumerary ribs (HP:0005815)1.96782695
108Retinal atrophy (HP:0001105)1.96637581
109Polyphagia (HP:0002591)1.94869883
110Abnormality of polysaccharide metabolism (HP:0011012)1.93875500
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93875500
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93875500
113Alopecia of scalp (HP:0002293)1.91996833
114Tetany (HP:0001281)1.90566864
115Subacute progressive viral hepatitis (HP:0006572)1.90058409
116Recurrent abscess formation (HP:0002722)1.89876300
117Hyperphosphaturia (HP:0003109)1.89686013
118Recurrent gram-negative bacterial infections (HP:0005420)1.89554789
119Skin nodule (HP:0200036)1.89276792
120Partial duplication of thumb phalanx (HP:0009944)1.89086650
121T lymphocytopenia (HP:0005403)1.88680572
122Partial duplication of the phalanx of hand (HP:0009999)1.87682870
123Abnormality of the Achilles tendon (HP:0005109)1.85968456
124Gastrointestinal infarctions (HP:0005244)1.85308231
125Gait imbalance (HP:0002141)1.85000176
126Inflammation of the large intestine (HP:0002037)1.84600438
127Agitation (HP:0000713)1.84322493
128Hypoglycemic coma (HP:0001325)1.84169437
129Macroorchidism (HP:0000053)1.83822527
130Hyperinsulinemic hypoglycemia (HP:0000825)1.82513950
131Hypoalphalipoproteinemia (HP:0003233)1.81997554
132Abnormality of glutamine family amino acid metabolism (HP:0010902)1.81892180
133Absent thumb (HP:0009777)1.81791787
134Conjunctival telangiectasia (HP:0000524)1.81628480
135Hyporeflexia of lower limbs (HP:0002600)1.81223562
136Retrobulbar optic neuritis (HP:0100654)1.80599209
137Optic neuritis (HP:0100653)1.80599209
138Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80118446
139Hypoplasia of the brainstem (HP:0002365)1.80118446
140Abnormal drinking behavior (HP:0030082)1.80080351
141Polydipsia (HP:0001959)1.80080351
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.79890491
143Osteolytic defects of the hand bones (HP:0009699)1.79890491
144Cleft eyelid (HP:0000625)1.79545321
145Ankle contracture (HP:0006466)1.79148816
146Abnormality of the incisor (HP:0000676)1.78553665
147Glycosuria (HP:0003076)1.77441346
148Abnormality of urine glucose concentration (HP:0011016)1.77441346
149Hypobetalipoproteinemia (HP:0003563)1.77128525
150Microretrognathia (HP:0000308)1.76883133
151Increased mean platelet volume (HP:0011877)1.76251393
152Ulnar bowing (HP:0003031)1.76062176
153Gastrointestinal inflammation (HP:0004386)1.75347381
154Hepatocellular necrosis (HP:0001404)1.75101586
155Depressed nasal ridge (HP:0000457)1.73792959
156Recurrent viral infections (HP:0004429)1.73149762
157Renal tubular acidosis (HP:0001947)1.72496639
158Menorrhagia (HP:0000132)1.71473197
159Hypercholesterolemia (HP:0003124)1.71356264
160Ketosis (HP:0001946)1.71212275
161Anophthalmia (HP:0000528)1.70830571
162Thick lower lip vermilion (HP:0000179)1.70653052
163Orchitis (HP:0100796)1.70280997
164Nephritis (HP:0000123)1.69862693
165Abnormal platelet volume (HP:0011876)1.68430793
166Camptodactyly of toe (HP:0001836)1.68362930
167Abnormal urine phosphate concentration (HP:0012599)1.68245038
168Arterial tortuosity (HP:0005116)1.68064257
169Ketoacidosis (HP:0001993)1.68014001
170Recurrent fungal infections (HP:0002841)1.67686402
171Nasolacrimal duct obstruction (HP:0000579)1.67457154
172Oligodontia (HP:0000677)1.66759531
173Pulmonary embolism (HP:0002204)1.66652319
174Abnormality of endocrine pancreas physiology (HP:0012093)1.65608660
175Abnormality of the pancreatic islet cells (HP:0006476)1.65608660
176Genu recurvatum (HP:0002816)1.65410794
177Achilles tendon contracture (HP:0001771)1.65392256
178Persistence of primary teeth (HP:0006335)1.64903307
179Porencephaly (HP:0002132)1.64800630
180Abnormality of T cell physiology (HP:0011840)1.64742249
181Viral hepatitis (HP:0006562)1.64357967
182Hypolipoproteinemia (HP:0010981)1.64086465
183Long toe (HP:0010511)1.63771233
184Nephrogenic diabetes insipidus (HP:0009806)1.63437893
185Fat malabsorption (HP:0002630)1.62620437
186Stroke (HP:0001297)1.62541859
187Anterior segment dysgenesis (HP:0007700)1.62397194
188Osteomalacia (HP:0002749)1.61569775
189Cardiovascular calcification (HP:0011915)1.60511028
190Optic disc pallor (HP:0000543)1.59635381
191Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59374391
192Increased serum lactate (HP:0002151)1.56034496
193Recurrent skin infections (HP:0001581)1.56004625
194Cerebral edema (HP:0002181)1.55756460
195Lactic acidosis (HP:0003128)1.55717500
196Medial flaring of the eyebrow (HP:0010747)1.53993644
197Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.53888819
198Missing ribs (HP:0000921)1.52753931
199Pancreatic cysts (HP:0001737)1.50646367
200Exercise intolerance (HP:0003546)1.49639735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.15115292
2TLK13.80160393
3TAOK23.31479195
4STK163.24899772
5RIPK13.21446096
6ERN13.20324027
7FGFR42.96903699
8TRIB32.82812488
9DYRK22.74454523
10EPHB12.73664458
11DYRK32.66810199
12VRK22.63667061
13EEF2K2.60968935
14SIK12.43566904
15IRAK32.39186195
16EPHA32.35885504
17TAF12.31587239
18CDK192.25436462
19MAP4K12.11827226
20IRAK42.11676863
21PKN21.91698923
22PTK61.84618502
23TGFBR21.80200692
24JAK31.76524179
25MAP3K101.74968765
26JAK11.68315661
27MAP2K31.68158341
28PNCK1.67786350
29PDGFRA1.64417664
30TBK11.56823897
31VRK11.55181602
32NLK1.54913872
33LATS11.54654633
34MAP3K21.50944690
35ABL21.50367414
36FGFR31.50179439
37TAOK31.49513610
38EPHB21.46827443
39MATK1.46493620
40CSK1.45822929
41MAPK151.43614464
42CASK1.43523030
43TYK21.40845814
44ZAP701.39126021
45IKBKE1.37430118
46MAP3K31.37059390
47MAP3K111.35203750
48STK101.34790435
49TNIK1.31384791
50FRK1.31133101
51MAP3K91.29340324
52RIPK41.28920241
53MARK11.24603857
54ITK1.23405154
55PDGFRB1.21933355
56TTN1.18485284
57RET1.18001905
58ZAK1.17614363
59CDK121.17352410
60MAP3K141.16995349
61NUAK11.16650430
62JAK21.15489365
63RPS6KA41.14130510
64GRK61.13824565
65CHUK1.11968432
66IRAK21.11854967
67PRKCH1.10815501
68HIPK21.10200811
69IKBKB1.05033480
70FER1.00924888
71PTK21.00733247
72BLK0.99355213
73PIM20.96325627
74SMG10.96243805
75NEK20.95010842
76DDR20.94860576
77MAP2K70.92450365
78MAP3K10.92047070
79BUB10.91746752
80CHEK20.90262361
81PASK0.88556058
82IRAK10.87695257
83LRRK20.86637121
84MAP3K60.86212977
85GSK3A0.85508490
86STK110.84450205
87ADRBK20.83497104
88DMPK0.82420566
89RPS6KA50.82238576
90MTOR0.81273618
91MAPKAPK30.79675699
92STK240.79296191
93NME20.76443435
94FLT30.76374433
95BMX0.74373376
96TYRO30.74066493
97PAK20.70192524
98PRKD20.69691920
99MAP3K70.69601618
100MAP3K130.69002777
101FGFR20.68438961
102TIE10.67155946
103PAK30.67093429
104CAMK1G0.65832247
105AURKA0.65712018
106RPS6KA60.63842704
107NTRK20.62811703
108HCK0.60806627
109MARK30.60709315
110RPS6KA10.60287272
111RPS6KC10.58240992
112RPS6KL10.58240992
113ICK0.57749620
114CDK80.56838562
115PRKCI0.56824774
116KSR20.56512502
117DYRK1B0.56302073
118SGK2230.56154666
119SGK4940.56154666
120MAPK120.55708278
121RPS6KB20.55668455
122PRKCZ0.54302404
123STK30.54073778
124LCK0.53659547
125KDR0.53433141
126FES0.52976503
127NTRK10.52345269
128NME10.52296547
129TRPM70.52020000
130RPS6KA20.51965544
131MAP2K40.51814514
132MARK20.50920101
133TAOK10.49487730
134PIM10.49154467
135PRKCQ0.47655194
136CDK60.47447057
137CAMK1D0.47170312
138PRKAA20.46374234
139EGFR0.46372387
140LYN0.46125193
141BMPR1B0.45944044
142RAF10.45028477
143CDC70.45013550
144INSR0.44737344
145ALK0.44075883
146PRKCD0.41845684
147SIK20.41015182
148BTK0.40693706
149PKN10.39569040
150CAMK40.39237158
151PRKCG0.39219735
152TESK10.38097694
153CDK30.38046278
154CSNK2A20.37395943
155PRKD30.36970714
156ABL10.36491137
157PRKD10.35482848
158IGF1R0.35342364
159PTK2B0.34484120
160GRK10.34253216
161WNK10.33919767
162MET0.33186610
163CDK70.31550698
164FGR0.30605464
165CSNK1E0.29163857
166AKT10.28948004
167TGFBR10.27923249
168DYRK1A0.27675722

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.21028058
2Oxidative phosphorylation_Homo sapiens_hsa001904.63986266
3Parkinsons disease_Homo sapiens_hsa050123.91172004
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.38003387
5Sulfur relay system_Homo sapiens_hsa041222.89264988
6Alzheimers disease_Homo sapiens_hsa050102.81215991
7Huntingtons disease_Homo sapiens_hsa050162.79318948
8RNA polymerase_Homo sapiens_hsa030202.42243249
9Nitrogen metabolism_Homo sapiens_hsa009102.32825727
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.11178618
11Cardiac muscle contraction_Homo sapiens_hsa042602.06518215
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95211045
13Arginine biosynthesis_Homo sapiens_hsa002201.82615695
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71412129
15Complement and coagulation cascades_Homo sapiens_hsa046101.70125639
16Notch signaling pathway_Homo sapiens_hsa043301.63279318
17Spliceosome_Homo sapiens_hsa030401.60363075
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58545736
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.56671175
20Osteoclast differentiation_Homo sapiens_hsa043801.52529757
21Basal transcription factors_Homo sapiens_hsa030221.52459910
22Insulin resistance_Homo sapiens_hsa049311.51621555
23ABC transporters_Homo sapiens_hsa020101.43948479
24Tryptophan metabolism_Homo sapiens_hsa003801.37444770
25Staphylococcus aureus infection_Homo sapiens_hsa051501.36725259
26Renal cell carcinoma_Homo sapiens_hsa052111.36237187
27Prolactin signaling pathway_Homo sapiens_hsa049171.35456308
28Caffeine metabolism_Homo sapiens_hsa002321.30234688
29Type II diabetes mellitus_Homo sapiens_hsa049301.28476392
30Toxoplasmosis_Homo sapiens_hsa051451.27028184
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21429825
32Protein export_Homo sapiens_hsa030601.20951920
33Selenocompound metabolism_Homo sapiens_hsa004501.20050459
34Lysine degradation_Homo sapiens_hsa003101.19717090
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.19127425
36Bile secretion_Homo sapiens_hsa049761.18062121
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15865787
38Chronic myeloid leukemia_Homo sapiens_hsa052201.15789992
39Collecting duct acid secretion_Homo sapiens_hsa049661.15445284
40TNF signaling pathway_Homo sapiens_hsa046681.13447411
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11501136
42Leishmaniasis_Homo sapiens_hsa051401.10150805
43Basal cell carcinoma_Homo sapiens_hsa052171.05789635
44T cell receptor signaling pathway_Homo sapiens_hsa046601.05489223
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.05195435
46Amoebiasis_Homo sapiens_hsa051461.04690006
47Prion diseases_Homo sapiens_hsa050201.03382589
48Antigen processing and presentation_Homo sapiens_hsa046121.02524095
49Dorso-ventral axis formation_Homo sapiens_hsa043201.02188963
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00446904
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00006810
52Acute myeloid leukemia_Homo sapiens_hsa052210.99194873
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.98945860
54Epstein-Barr virus infection_Homo sapiens_hsa051690.98408263
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97459072
56B cell receptor signaling pathway_Homo sapiens_hsa046620.95828679
57Primary immunodeficiency_Homo sapiens_hsa053400.94042218
58p53 signaling pathway_Homo sapiens_hsa041150.93547425
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93147176
60Fatty acid degradation_Homo sapiens_hsa000710.92617058
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92423213
62Fat digestion and absorption_Homo sapiens_hsa049750.92288301
63PPAR signaling pathway_Homo sapiens_hsa033200.92011529
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91434257
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90553686
66Focal adhesion_Homo sapiens_hsa045100.90225203
67Small cell lung cancer_Homo sapiens_hsa052220.87196873
68Chemical carcinogenesis_Homo sapiens_hsa052040.86519077
69Measles_Homo sapiens_hsa051620.84999207
70Malaria_Homo sapiens_hsa051440.84634103
71Hepatitis C_Homo sapiens_hsa051600.84285723
72ErbB signaling pathway_Homo sapiens_hsa040120.83366457
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83256712
74Pancreatic cancer_Homo sapiens_hsa052120.82946855
75ECM-receptor interaction_Homo sapiens_hsa045120.81750335
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80982568
77Adherens junction_Homo sapiens_hsa045200.80489271
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79216996
79Influenza A_Homo sapiens_hsa051640.78998422
80Prostate cancer_Homo sapiens_hsa052150.78146297
81Base excision repair_Homo sapiens_hsa034100.78018190
82Homologous recombination_Homo sapiens_hsa034400.77397365
83Proteoglycans in cancer_Homo sapiens_hsa052050.77246195
84Pyrimidine metabolism_Homo sapiens_hsa002400.75956882
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.75060120
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74571795
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.73532446
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72543893
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72077156
90Starch and sucrose metabolism_Homo sapiens_hsa005000.71933297
91Hepatitis B_Homo sapiens_hsa051610.71708752
92Hedgehog signaling pathway_Homo sapiens_hsa043400.71102307
93Phagosome_Homo sapiens_hsa041450.71052444
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71014389
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70305192
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69833816
97MAPK signaling pathway_Homo sapiens_hsa040100.69814919
98mTOR signaling pathway_Homo sapiens_hsa041500.69136613
99VEGF signaling pathway_Homo sapiens_hsa043700.68361547
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68294238
101Platelet activation_Homo sapiens_hsa046110.67807434
102Protein digestion and absorption_Homo sapiens_hsa049740.67661565
103Sulfur metabolism_Homo sapiens_hsa009200.67532698
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66526906
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66251662
106RNA degradation_Homo sapiens_hsa030180.65582000
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.64957641
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64248431
109FoxO signaling pathway_Homo sapiens_hsa040680.63898119
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63817738
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.63324802
112Histidine metabolism_Homo sapiens_hsa003400.63219454
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62530152
114Pertussis_Homo sapiens_hsa051330.62103729
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61983090
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61541583
117Estrogen signaling pathway_Homo sapiens_hsa049150.61497304
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60473016
119Apoptosis_Homo sapiens_hsa042100.60406514
120Axon guidance_Homo sapiens_hsa043600.59869666
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59780611
122Chemokine signaling pathway_Homo sapiens_hsa040620.59708293
123Melanoma_Homo sapiens_hsa052180.56838094
124Endometrial cancer_Homo sapiens_hsa052130.56365897
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56312958
126Herpes simplex infection_Homo sapiens_hsa051680.54818096
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54247345
128Fatty acid metabolism_Homo sapiens_hsa012120.53088443
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52692213
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51401318
131Legionellosis_Homo sapiens_hsa051340.51246674
132African trypanosomiasis_Homo sapiens_hsa051430.51150932
133Phenylalanine metabolism_Homo sapiens_hsa003600.51083346
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50946832
135Viral myocarditis_Homo sapiens_hsa054160.50560539
136Bladder cancer_Homo sapiens_hsa052190.50231226
137Colorectal cancer_Homo sapiens_hsa052100.49976501
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49786512
139Rheumatoid arthritis_Homo sapiens_hsa053230.49589178
140Tuberculosis_Homo sapiens_hsa051520.49358649
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.48975681
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48073148
143Glioma_Homo sapiens_hsa052140.47505178
144Viral carcinogenesis_Homo sapiens_hsa052030.47426992
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47368190
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.46549727
147Glycerolipid metabolism_Homo sapiens_hsa005610.45976856
148Butanoate metabolism_Homo sapiens_hsa006500.45616778
149Shigellosis_Homo sapiens_hsa051310.42694364
150Pathways in cancer_Homo sapiens_hsa052000.41467418
151Systemic lupus erythematosus_Homo sapiens_hsa053220.35045186
152RNA transport_Homo sapiens_hsa030130.34054924
153Other glycan degradation_Homo sapiens_hsa005110.32886533
154Nucleotide excision repair_Homo sapiens_hsa034200.31978036
155Alcoholism_Homo sapiens_hsa050340.31836167
156Fanconi anemia pathway_Homo sapiens_hsa034600.31782691
157Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31770192
158Non-small cell lung cancer_Homo sapiens_hsa052230.29157293
159Wnt signaling pathway_Homo sapiens_hsa043100.28937371
160Folate biosynthesis_Homo sapiens_hsa007900.28082917
161Phototransduction_Homo sapiens_hsa047440.24621817
162Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24281117
163Regulation of autophagy_Homo sapiens_hsa041400.23960909

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