GBP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.37965845
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.37965845
3antigen processing and presentation of endogenous antigen (GO:0019883)6.12167478
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.68080168
5cellular response to type I interferon (GO:0071357)5.62920576
6type I interferon signaling pathway (GO:0060337)5.62920576
7response to type I interferon (GO:0034340)5.62287462
8positive regulation of interferon-alpha production (GO:0032727)5.47529327
9regulation of interferon-alpha production (GO:0032647)5.18603845
10response to interferon-alpha (GO:0035455)5.04181110
11regulation of vitamin metabolic process (GO:0030656)4.71763388
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.56854503
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.56854503
14modulation by symbiont of host immune response (GO:0052553)4.56854503
15positive regulation by symbiont of host defense response (GO:0052509)4.56854503
16modulation by symbiont of host defense response (GO:0052031)4.56854503
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.56854503
18cellular response to interferon-beta (GO:0035458)4.48924332
19cellular response to interferon-alpha (GO:0035457)4.34455744
20regulation of vitamin D biosynthetic process (GO:0060556)4.31193975
21interferon-gamma-mediated signaling pathway (GO:0060333)4.23418990
22neutrophil activation involved in immune response (GO:0002283)4.20376265
23response to interferon-beta (GO:0035456)4.15659738
24response to peptidoglycan (GO:0032494)4.14052591
25negative regulation of viral genome replication (GO:0045071)4.11034539
26cellular response to exogenous dsRNA (GO:0071360)4.00809005
27immunoglobulin mediated immune response (GO:0016064)4.00100314
28positive regulation of interferon-beta production (GO:0032728)3.91541795
29lipopolysaccharide-mediated signaling pathway (GO:0031663)3.90691843
30angiotensin maturation (GO:0002003)3.88341206
31positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.87499847
32positive regulation of natural killer cell differentiation (GO:0032825)3.85237631
33regulation of RIG-I signaling pathway (GO:0039535)3.83820342
34regulation of interferon-beta biosynthetic process (GO:0045357)3.82383371
35T cell migration (GO:0072678)3.73306627
36positive regulation of gamma-delta T cell activation (GO:0046645)3.70331088
37T-helper 1 type immune response (GO:0042088)3.67277124
38defense response to protozoan (GO:0042832)3.67000584
39regulation of T-helper 1 cell differentiation (GO:0045625)3.66125111
40macrophage activation involved in immune response (GO:0002281)3.62324747
41cellular response to virus (GO:0098586)3.61019589
42positive regulation of type 2 immune response (GO:0002830)3.60311134
43respiratory burst (GO:0045730)3.58291080
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.50986354
45cellular response to interferon-gamma (GO:0071346)3.49193106
46negative regulation of cell killing (GO:0031342)3.48768048
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48768048
48regulation of type I interferon-mediated signaling pathway (GO:0060338)3.48125668
49positive regulation of antigen processing and presentation (GO:0002579)3.46584691
50natural killer cell mediated immunity (GO:0002228)3.46387241
51natural killer cell mediated cytotoxicity (GO:0042267)3.46387241
52response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.43458992
53response to host immune response (GO:0052572)3.43458992
54positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.43005426
55response to muramyl dipeptide (GO:0032495)3.32524990
56positive regulation of interleukin-12 production (GO:0032735)3.32315387
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.31524178
58response to protozoan (GO:0001562)3.28563909
59positive regulation of tolerance induction (GO:0002645)3.27529769
60positive regulation of cAMP-mediated signaling (GO:0043950)3.25827312
61* defense response to virus (GO:0051607)3.24122145
62myeloid dendritic cell differentiation (GO:0043011)3.23871362
63granulocyte activation (GO:0036230)3.22354800
64lymphocyte chemotaxis (GO:0048247)3.20473394
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.19298523
66regulation of T cell tolerance induction (GO:0002664)3.19047744
67regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.18531347
68regulation of tolerance induction (GO:0002643)3.17318547
69hydrogen peroxide biosynthetic process (GO:0050665)3.15575378
70neutrophil activation (GO:0042119)3.15153792
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.14256032
72response to interferon-gamma (GO:0034341)3.12203793
73regulation of cellular extravasation (GO:0002691)3.11898947
74cellular response to zinc ion (GO:0071294)3.11272470
75regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.10755581
76regulation of activation of Janus kinase activity (GO:0010533)3.10455926
77regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.09993125
78virion attachment to host cell (GO:0019062)3.09872783
79adhesion of symbiont to host cell (GO:0044650)3.09872783
80myeloid dendritic cell activation (GO:0001773)3.08316886
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07634717
82response to host (GO:0075136)3.07634717
83response to host defenses (GO:0052200)3.07634717
84positive regulation of chemokine biosynthetic process (GO:0045080)3.06802956
85regulation of antigen processing and presentation (GO:0002577)3.04357936
86B cell mediated immunity (GO:0019724)3.04121380
87positive regulation of T cell cytokine production (GO:0002726)3.00758177
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.99427768
89regulation of B cell receptor signaling pathway (GO:0050855)2.98918713
90reactive oxygen species biosynthetic process (GO:1903409)2.98141128
91regulation of chemokine biosynthetic process (GO:0045073)2.96529380
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96291779
93myeloid cell activation involved in immune response (GO:0002275)2.94581768
94regulation of regulatory T cell differentiation (GO:0045589)2.93419846
95positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91868683
96regulation of interferon-gamma biosynthetic process (GO:0045072)2.91550989
97regulation of T cell mediated cytotoxicity (GO:0001914)2.91318189
98regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90500601
99positive regulation of response to biotic stimulus (GO:0002833)2.90115687
100regulation of interferon-beta production (GO:0032648)2.89301790
101leukocyte mediated cytotoxicity (GO:0001909)2.87673474
102detection of molecule of bacterial origin (GO:0032490)2.87027303
103regulation of alpha-beta T cell proliferation (GO:0046640)2.84084624
104positive regulation of defense response to virus by host (GO:0002230)2.82377521
105positive regulation of interleukin-17 production (GO:0032740)2.82259443
106response to exogenous dsRNA (GO:0043330)2.81321158
107production of molecular mediator involved in inflammatory response (GO:0002532)2.79762132
108regulation of interleukin-12 production (GO:0032655)2.78503247
109monocyte chemotaxis (GO:0002548)2.76886692
110microglial cell activation (GO:0001774)2.76610575
111detection of other organism (GO:0098543)2.76426696
112negative regulation of interleukin-17 production (GO:0032700)2.74841205
113regulation of response to interferon-gamma (GO:0060330)2.74531800
114antigen processing and presentation via MHC class Ib (GO:0002475)2.73152689
115positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.71691059
116positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.71567700
117NIK/NF-kappaB signaling (GO:0038061)2.70570938
118JAK-STAT cascade (GO:0007259)2.68316912
119eosinophil chemotaxis (GO:0048245)2.68219103
120detection of bacterium (GO:0016045)2.67244415
121regulation of leukocyte mediated cytotoxicity (GO:0001910)2.66465488
122cytidine deamination (GO:0009972)2.57192290
123cytidine metabolic process (GO:0046087)2.57192290
124cytidine catabolic process (GO:0006216)2.57192290
125negative regulation of interleukin-12 production (GO:0032695)2.56274463
126regulation of mononuclear cell migration (GO:0071675)2.54775880
127intestinal absorption (GO:0050892)2.52361034
128peptide catabolic process (GO:0043171)2.49157879
129adhesion of symbiont to host (GO:0044406)2.47602791
130pyrimidine ribonucleoside catabolic process (GO:0046133)2.46905433
131epoxygenase P450 pathway (GO:0019373)2.46534134
132regulation of gamma-delta T cell activation (GO:0046643)2.46254091
133regulation of toll-like receptor signaling pathway (GO:0034121)2.45913023
134regulation of natural killer cell mediated immunity (GO:0002715)2.45156329
135regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.45156329
136T cell costimulation (GO:0031295)2.42796168
137detection of external biotic stimulus (GO:0098581)2.40070475
138lymphocyte costimulation (GO:0031294)2.38855416
139fat-soluble vitamin biosynthetic process (GO:0042362)2.37813816
140lipoprotein transport (GO:0042953)2.36810859
141regulation of type 2 immune response (GO:0002828)2.36185321
142positive regulation of cell killing (GO:0031343)2.35591857
143regulation of cell killing (GO:0031341)2.35173954
144eosinophil migration (GO:0072677)2.34621170
145interferon-gamma secretion (GO:0072643)2.34074130
146leukocyte aggregation (GO:0070486)2.31067280
147positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.30755957
148negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.26352608
149regulation of gamma-delta T cell differentiation (GO:0045586)2.26208524
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.24692222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.34113217
2* IRF8_21731497_ChIP-ChIP_J774_Mouse6.72479168
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human6.47063521
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.24345172
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.88047005
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54480273
7* IRF8_27001747_Chip-Seq_BMDM_Mouse4.11298643
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49466239
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.48520866
10* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36599011
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.14280974
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00089444
13GATA1_22025678_ChIP-Seq_K562_Human2.97506976
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96678369
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.96113364
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76158574
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.68976791
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65887537
19* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.22040885
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20476930
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.09057781
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04474977
23MYB_26560356_Chip-Seq_TH2_Human1.97854634
24SPI1_23547873_ChIP-Seq_NB4_Human1.86344602
25MAF_26560356_Chip-Seq_TH1_Human1.80805954
26RUNX_20019798_ChIP-Seq_JUKART_Human1.80295116
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.76000119
28* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75781261
29SCL_19346495_ChIP-Seq_HPC-7_Human1.73723913
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65440064
31MYB_26560356_Chip-Seq_TH1_Human1.61249776
32PU_27001747_Chip-Seq_BMDM_Mouse1.57495222
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56554340
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55007534
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50295624
36VDR_24763502_ChIP-Seq_THP-1_Human1.50217561
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.50108064
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49755073
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47597032
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.45114091
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.44461111
42SPI1_23127762_ChIP-Seq_K562_Human1.44387476
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42433500
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.42369236
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41147224
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41029779
47CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39777872
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.34560729
49VDR_24787735_ChIP-Seq_THP-1_Human1.33192454
50FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31540429
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30210218
52GATA4_25053715_ChIP-Seq_YYC3_Human1.29912551
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27077292
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26860346
55VDR_21846776_ChIP-Seq_THP-1_Human1.20617815
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19556030
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.18572667
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16771423
59* GATA3_27048872_Chip-Seq_THYMUS_Human1.16548290
60* GATA3_26560356_Chip-Seq_TH2_Human1.14676575
61EGR1_19032775_ChIP-ChIP_M12_Human1.13925150
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13871457
63JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13525442
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.12856717
65P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12783190
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12665701
67UTX_26944678_Chip-Seq_JUKART_Human1.11853995
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09100172
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08963918
70* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08474528
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08359776
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07830272
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.05853148
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05749170
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04802431
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03624931
77* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03041763
78* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02610552
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.01717068
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01397484
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01266943
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00341800
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98696388
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98300906
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92414954
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92289364
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.92199527
88TP63_23658742_ChIP-Seq_EP156T_Human0.91416195
89GATA6_25053715_ChIP-Seq_YYC3_Human0.91206997
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90814008
91STAT1_20625510_ChIP-Seq_HELA_Human0.90602341
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90581915
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90397892
94* MAF_26560356_Chip-Seq_TH2_Human0.89201057
95FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89114252
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85922714
97* SOX2_20726797_ChIP-Seq_SW620_Human0.85472009
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84388378
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.78495555
100KLF5_25053715_ChIP-Seq_YYC3_Human0.78215928
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78073727
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.77554752
103TCF7_22412390_ChIP-Seq_EML_Mouse0.76397957
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.73641259
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72847337
106GATA2_19941826_ChIP-Seq_K562_Human0.70188398
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.67810741
108GATA1_19941826_ChIP-Seq_K562_Human0.66846215
109SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.66303822
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.66303822
111TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64913636
112KDM2B_26808549_Chip-Seq_SUP-B15_Human0.64897016
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.63103047
114MYC_22102868_ChIP-Seq_BL_Human0.62160685
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.61014014
116PU.1_20513432_ChIP-Seq_Bcells_Mouse0.60849749
117SPI1_20517297_ChIP-Seq_HL60_Human0.60730658
118RXR_22158963_ChIP-Seq_LIVER_Mouse0.60228907
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.59585808
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.59585808
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59115536
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.58709831
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.58690224
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58660749
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.58252330
126CJUN_26792858_Chip-Seq_BT549_Human0.57456109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.84474635
2MP0009785_altered_susceptibility_to4.13430954
3MP0003724_increased_susceptibility_to3.88657604
4MP0002148_abnormal_hypersensitivity_rea3.35392614
5MP0003436_decreased_susceptibility_to3.25272534
6MP0000685_abnormal_immune_system3.13687251
7MP0005387_immune_system_phenotype3.12134116
8MP0001790_abnormal_immune_system3.12134116
9MP0005360_urolithiasis3.11442531
10MP0005025_abnormal_response_to3.10661975
11MP0005000_abnormal_immune_tolerance3.05724055
12MP0006082_CNS_inflammation3.04795865
13MP0003303_peritoneal_inflammation3.00580575
14MP0005671_abnormal_response_to3.00391464
15MP0002419_abnormal_innate_immunity2.82844387
16MP0001800_abnormal_humoral_immune2.71588616
17MP0002452_abnormal_antigen_presenting2.65914870
18MP0004510_myositis2.58594183
19MP0002723_abnormal_immune_serum2.57340733
20MP0002139_abnormal_hepatobiliary_system2.29026098
21MP0001819_abnormal_immune_cell2.28615448
22MP0002420_abnormal_adaptive_immunity2.24321886
23MP0002006_tumorigenesis2.23044244
24MP0002166_altered_tumor_susceptibility2.15095607
25MP0001533_abnormal_skeleton_physiology2.05309913
26MP0001853_heart_inflammation2.04726532
27MP0004947_skin_inflammation1.95833079
28MP0009764_decreased_sensitivity_to1.90135675
29MP0005058_abnormal_lysosome_morphology1.88698275
30MP0005464_abnormal_platelet_physiology1.87884171
31MP0001845_abnormal_inflammatory_respons1.85947275
32MP0005085_abnormal_gallbladder_physiolo1.83028112
33MP0010155_abnormal_intestine_physiology1.82828937
34MP0008469_abnormal_protein_level1.74746726
35MP0003448_altered_tumor_morphology1.73457614
36MP0000716_abnormal_immune_system1.72675604
37MP0000343_altered_response_to1.69037120
38MP0002398_abnormal_bone_marrow1.68029907
39MP0002405_respiratory_system_inflammati1.66935342
40MP0001666_abnormal_nutrient_absorption1.66674656
41MP0009333_abnormal_splenocyte_physiolog1.59639247
42MP0009278_abnormal_bone_marrow1.58270244
43MP0003075_altered_response_to1.56953457
44MP0005397_hematopoietic_system_phenotyp1.56528285
45MP0001545_abnormal_hematopoietic_system1.56528285
46MP0003300_gastrointestinal_ulcer1.55049771
47MP0005365_abnormal_bile_salt1.53110262
48MP0005167_abnormal_blood-brain_barrier1.53103826
49MP0009780_abnormal_chondrocyte_physiolo1.41304554
50MP0002429_abnormal_blood_cell1.39083289
51MP0002998_abnormal_bone_remodeling1.35655931
52MP0000689_abnormal_spleen_morphology1.35288422
53MP0003763_abnormal_thymus_physiology1.34490659
54MP0003191_abnormal_cellular_cholesterol1.33103644
55MP0000858_altered_metastatic_potential1.27366271
56MP0002722_abnormal_immune_system1.27305587
57MP0010368_abnormal_lymphatic_system1.25526496
58MP0001879_abnormal_lymphatic_vessel1.21681353
59MP0005310_abnormal_salivary_gland1.21645947
60MP0003806_abnormal_nucleotide_metabolis1.20962392
61MP0004019_abnormal_vitamin_homeostasis1.17155777
62MP0008004_abnormal_stomach_pH1.14319341
63MP0001663_abnormal_digestive_system1.14197118
64MP0009643_abnormal_urine_homeostasis1.12884019
65MP0008438_abnormal_cutaneous_collagen1.12710831
66MP0004808_abnormal_hematopoietic_stem1.12090880
67MP0009763_increased_sensitivity_to1.11848129
68MP0003186_abnormal_redox_activity1.10673342
69MP0003252_abnormal_bile_duct1.09996827
70MP0005164_abnormal_response_to1.09365988
71MP0003172_abnormal_lysosome_physiology1.08112737
72MP0004264_abnormal_extraembryonic_tissu1.07510912
73MP0005166_decreased_susceptibility_to1.07077916
74MP0002138_abnormal_hepatobiliary_system1.03744426
75MP0000604_amyloidosis1.01158642
76MP0004883_abnormal_blood_vessel1.01024871
77MP0003091_abnormal_cell_migration0.98238079
78MP0004782_abnormal_surfactant_physiolog0.97900018
79MP0003828_pulmonary_edema0.97485930
80MP0001542_abnormal_bone_strength0.96629707
81MP0010307_abnormal_tumor_latency0.96611786
82MP0010234_abnormal_vibrissa_follicle0.96590181
83MP0000249_abnormal_blood_vessel0.95366927
84MP0005390_skeleton_phenotype0.95060087
85MP0002254_reproductive_system_inflammat0.94111747
86MP0005451_abnormal_body_composition0.91159329
87MP0009840_abnormal_foam_cell0.89845287
88MP0008875_abnormal_xenobiotic_pharmacok0.89824336
89MP0001851_eye_inflammation0.88055884
90MP0002933_joint_inflammation0.87667069
91MP0001765_abnormal_ion_homeostasis0.87138798
92MP0001873_stomach_inflammation0.86924477
93MP0003045_fibrosis0.85754398
94MP0003950_abnormal_plasma_membrane0.83918831
95MP0003690_abnormal_glial_cell0.83683005
96MP0003566_abnormal_cell_adhesion0.82850949
97MP0008260_abnormal_autophagy0.82839342
98MP0002396_abnormal_hematopoietic_system0.82202930
99MP0001958_emphysema0.81489976
100MP0005381_digestive/alimentary_phenotyp0.79362030
101MP0005275_abnormal_skin_tensile0.78446396
102MP0000767_abnormal_smooth_muscle0.77942128
103MP0001664_abnormal_digestion0.77505377
104MP0005023_abnormal_wound_healing0.74733959
105MP0000703_abnormal_thymus_morphology0.74658785
106MP0002136_abnormal_kidney_physiology0.73359930
107MP0003453_abnormal_keratinocyte_physiol0.73358645
108MP0000465_gastrointestinal_hemorrhage0.70397894
109MP0003183_abnormal_peptide_metabolism0.69633992
110MP0010352_gastrointestinal_tract_polyps0.66684984
111MP0002277_abnormal_respiratory_mucosa0.64779878
112MP0003705_abnormal_hypodermis_morpholog0.63392409
113MP0003866_abnormal_defecation0.61121718
114MP0003795_abnormal_bone_structure0.59055937
115MP0009765_abnormal_xenobiotic_induced0.58168643
116MP0005165_increased_susceptibility_to0.58081926
117MP0001881_abnormal_mammary_gland0.57225961
118MP0005319_abnormal_enzyme/_coenzyme0.53055970
119MP0003279_aneurysm0.52276712
120MP0000609_abnormal_liver_physiology0.51108615
121MP0005076_abnormal_cell_differentiation0.49874031
122MP0000490_abnormal_crypts_of0.49624432
123MP0001915_intracranial_hemorrhage0.49298992
124MP0006054_spinal_hemorrhage0.49002357

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.20671417
2Eczematoid dermatitis (HP:0000976)6.18060862
3Recurrent bacterial skin infections (HP:0005406)5.74099790
4Elevated erythrocyte sedimentation rate (HP:0003565)5.09226478
5Chronic otitis media (HP:0000389)5.05463956
6Recurrent gram-negative bacterial infections (HP:0005420)4.72884145
7Autoimmune thrombocytopenia (HP:0001973)4.58136734
8Mediastinal lymphadenopathy (HP:0100721)4.45456589
9Abnormality of macrophages (HP:0004311)4.39804190
10Myositis (HP:0100614)4.18174193
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09558752
12Systemic lupus erythematosus (HP:0002725)4.06063762
13Increased IgM level (HP:0003496)3.87725728
14Vasculitis (HP:0002633)3.86194165
15Recurrent skin infections (HP:0001581)3.83103703
16Recurrent fungal infections (HP:0002841)3.83099058
17Recurrent viral infections (HP:0004429)3.81523307
18Chronic diarrhea (HP:0002028)3.80932994
19Abnormality of the nasal mucosa (HP:0000433)3.80063200
20Orchitis (HP:0100796)3.75319475
21Malnutrition (HP:0004395)3.73991231
22Nasal polyposis (HP:0100582)3.70778580
23Vacuolated lymphocytes (HP:0001922)3.63308209
24Basal ganglia calcification (HP:0002135)3.58543051
25Recurrent bronchitis (HP:0002837)3.56984651
26Stomatitis (HP:0010280)3.49187617
27Gingivitis (HP:0000230)3.40843192
28Retrobulbar optic neuritis (HP:0100654)3.38211419
29Optic neuritis (HP:0100653)3.38211419
30Interstitial pulmonary disease (HP:0006530)3.37153155
31Hypergammaglobulinemia (HP:0010702)3.29112030
32Hydroxyprolinuria (HP:0003080)3.20746643
33Abnormality of proline metabolism (HP:0010907)3.20746643
34Cellulitis (HP:0100658)3.14813567
35Chronic mucocutaneous candidiasis (HP:0002728)3.13026997
36Recurrent cutaneous fungal infections (HP:0011370)3.13026997
37Chronic obstructive pulmonary disease (HP:0006510)3.08986840
38Obstructive lung disease (HP:0006536)3.08986840
39Periodontitis (HP:0000704)3.01413333
40Chronic sinusitis (HP:0011109)3.01410299
41Thick nail (HP:0001805)3.00309627
42Increased cerebral lipofuscin (HP:0011813)2.94557474
43Spontaneous hematomas (HP:0007420)2.94498624
44Pustule (HP:0200039)2.94346441
45Hematochezia (HP:0002573)2.93953023
46Gastrointestinal infarctions (HP:0005244)2.89642503
47T lymphocytopenia (HP:0005403)2.88285424
48Tetraparesis (HP:0002273)2.85962352
49Pulmonary infiltrates (HP:0002113)2.81769685
50Abnormality of B cell number (HP:0010975)2.81248738
51Porencephaly (HP:0002132)2.79726861
52Meningitis (HP:0001287)2.76896376
53Hemoptysis (HP:0002105)2.75926742
54Increased neuronal autofluorescent lipopigment (HP:0002074)2.75130012
55Hyperactive renin-angiotensin system (HP:0000841)2.69892885
56Colitis (HP:0002583)2.64848134
57Arterial thrombosis (HP:0004420)2.61370292
58Petechiae (HP:0000967)2.60007765
59Autoimmune hemolytic anemia (HP:0001890)2.56635434
60Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.54954248
61B lymphocytopenia (HP:0010976)2.53792858
62Abnormality of liposaccharide metabolism (HP:0010968)2.53186288
63Abnormality of glycosphingolipid metabolism (HP:0004343)2.53186288
64Abnormality of glycolipid metabolism (HP:0010969)2.53186288
65Urticaria (HP:0001025)2.52016663
66Leukocytosis (HP:0001974)2.50039561
67Emphysema (HP:0002097)2.49122737
68Osteomyelitis (HP:0002754)2.48789308
69Prostate neoplasm (HP:0100787)2.44778897
70Myocardial infarction (HP:0001658)2.43501307
71Gastrointestinal stroma tumor (HP:0100723)2.42137186
72IgA deficiency (HP:0002720)2.41871411
73Gingival bleeding (HP:0000225)2.41631633
74Encephalitis (HP:0002383)2.41536153
75Abnormality of T cell physiology (HP:0011840)2.40531569
76Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.39634726
77Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39516188
78Eosinophilia (HP:0001880)2.38048220
79Abnormal delayed hypersensitivity skin test (HP:0002963)2.37382124
80Glomerulonephritis (HP:0000099)2.36966364
81Thrombocytosis (HP:0001894)2.35980335
82Recurrent pneumonia (HP:0006532)2.33156456
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.32684680
84Osteolytic defects of the hand bones (HP:0009699)2.32684680
85Recurrent lower respiratory tract infections (HP:0002783)2.32360300
86Thin bony cortex (HP:0002753)2.32124811
87Inflammation of the large intestine (HP:0002037)2.30925143
88Bronchitis (HP:0012387)2.30230734
89Abnormality of complement system (HP:0005339)2.30076725
90Agammaglobulinemia (HP:0004432)2.29987177
91Complement deficiency (HP:0004431)2.28734121
92Loss of speech (HP:0002371)2.26471068
93Protuberant abdomen (HP:0001538)2.26147765
94Abnormality of T cells (HP:0002843)2.25386656
95Abnormality of T cell number (HP:0011839)2.24536015
96Nephritis (HP:0000123)2.24140914
97Fat malabsorption (HP:0002630)2.23743970
98Increased IgE level (HP:0003212)2.23461429
99Premature loss of primary teeth (HP:0006323)2.23304190
100Papilledema (HP:0001085)2.23111956
101Keratoconjunctivitis sicca (HP:0001097)2.22773909
102Gastrointestinal inflammation (HP:0004386)2.18231157
103Skin ulcer (HP:0200042)2.18103940
104Joint swelling (HP:0001386)2.16602844
105Abnormality of the pericardium (HP:0001697)2.15245225
106Esophageal varix (HP:0002040)2.13232805
107Dysostosis multiplex (HP:0000943)2.12822451
108Purpura (HP:0000979)2.12711056
109Chest pain (HP:0100749)2.12531317
110Bronchiectasis (HP:0002110)2.11372150
111Esophageal neoplasm (HP:0100751)2.08450127
112Neoplasm of head and neck (HP:0012288)2.08450127
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.08050044
114Joint hemorrhage (HP:0005261)2.07215778
115Peritonitis (HP:0002586)2.06819988
116Poor head control (HP:0002421)2.06452536
117Axonal loss (HP:0003447)2.06197771
118Abnormality of the prostate (HP:0008775)2.05467562
119Lymphopenia (HP:0001888)2.04934441
120Abnormality of the frontal sinuses (HP:0002687)2.04794700
121Epistaxis (HP:0000421)2.02253021
122Amyloidosis (HP:0011034)2.01865014
123Abnormality of the costochondral junction (HP:0000919)2.01297593
124Keratoconjunctivitis (HP:0001096)2.01246910
125IgG deficiency (HP:0004315)2.00694134
126Decreased circulating renin level (HP:0003351)2.00338970
127Spondylolisthesis (HP:0003302)2.00120643
128Urinary glycosaminoglycan excretion (HP:0003541)1.99879383
129Mucopolysacchariduria (HP:0008155)1.99879383
130Abnormality of the vitamin B12 metabolism (HP:0004341)1.96778918
131Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93518028
132Abdominal distention (HP:0003270)1.92937223
133Abnormality of oral frenula (HP:0000190)1.92558381
134Hemorrhage of the eye (HP:0011885)1.91132260
135Cheilitis (HP:0100825)1.90644401
136Ileus (HP:0002595)1.90483156
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89938715
138Abnormality of polysaccharide metabolism (HP:0011012)1.89938715
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89938715
140Abnormal glucose tolerance (HP:0001952)1.88083621
141Aortic aneurysm (HP:0004942)1.87962013
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.86460325
143Absent/shortened dynein arms (HP:0200106)1.86460325
144Aortic dissection (HP:0002647)1.86436503
145Widely patent fontanelles and sutures (HP:0004492)1.83916606
146Skin rash (HP:0000988)1.83866077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.13108560
2MAP3K143.96333307
3TBK13.79987460
4IKBKE3.46443703
5PBK3.38311375
6JAK33.23712963
7BLK3.21495767
8JAK12.94855521
9KIT2.86195553
10RIPK42.82153044
11IRAK42.77963280
12MAP4K12.76574325
13FGFR42.48941603
14SCYL22.48252387
15IRAK32.26084858
16IKBKB2.16702859
17TXK2.09054968
18ACVR1B2.06251468
19ERN12.04959688
20PIM21.90830810
21MAP3K131.87355557
22EPHA21.74967605
23MAP3K31.71889363
24FGFR31.70468028
25CSK1.70343116
26MYLK1.51413000
27ZAP701.49254615
28CHUK1.43664175
29TAOK31.42069701
30MST41.41821736
31TIE11.37542525
32EPHB11.36145341
33TEC1.35745115
34NEK91.35062077
35EPHA31.30681933
36TGFBR21.29653659
37SYK1.24574788
38PRPF4B1.24546461
39TESK21.24066497
40DDR21.20995724
41LMTK21.17848838
42RPS6KA41.17291334
43LCK1.16304891
44HCK1.15504399
45PRKG21.15262418
46JAK21.11948149
47IRAK11.09329055
48CSF1R1.09070158
49MATK1.08827386
50BTK1.08211538
51NME21.04130390
52LYN1.01263380
53PIM10.99388026
54MARK30.99279105
55CDC42BPA0.97864844
56STK100.97411876
57MAP3K20.92881565
58TRPM70.92765788
59FES0.88902159
60MAP3K50.87121748
61RIPK10.86244668
62STK40.83853922
63FGR0.83297513
64EIF2AK20.83282564
65TESK10.82012421
66BMX0.78266273
67SIK20.77920279
68NLK0.77730498
69SIK30.75096015
70PIK3CG0.74467659
71KDR0.73147803
72TGFBR10.72883151
73PIK3CA0.69574615
74LRRK20.68412409
75MAP2K60.67165701
76MET0.63896252
77BMPR20.63594328
78TAOK20.62026648
79EGFR0.60339672
80INSRR0.60072593
81ABL20.60043638
82IRAK20.59428731
83MAP3K110.58228688
84ITK0.57763503
85PRKD20.56255560
86STK240.54554186
87DMPK0.53987197
88ABL10.53678022
89CAMK1D0.52183016
90PDGFRA0.51062628
91MAPKAPK30.50158122
92PAK40.49791880
93FLT30.49670624
94MST1R0.49557202
95PRKCD0.48907457
96STK380.47970410
97TTN0.47488997
98HIPK20.46051454
99PRKCQ0.45996554
100TAOK10.43627017
101MAP2K30.43241238
102MAPK110.42620333
103PDPK10.41733095
104ADRBK20.41195775
105PTK2B0.39933975
106PDK10.39075660
107MAPK70.38596200
108IGF1R0.37013970
109PKN20.36856381
110PTK60.36546768
111SIK10.36494512
112CLK10.35576424
113MELK0.35224341
114MAP3K100.34968850
115CDK60.34776116
116MAP3K60.33317404
117ARAF0.32034798
118STK30.32030922
119RPS6KA50.31965648
120GRK70.31623547
121RPS6KA60.29840649
122DAPK30.28546808
123TRIB30.26738234
124PDGFRB0.25569513
125MAPK40.24923007
126CAMKK20.24795646
127YES10.24523012
128MAP3K120.24155434
129MOS0.24021622
130MAPKAPK20.23742115
131FYN0.23251421
132MAP3K10.21871150
133PRKCH0.21360367
134GRK60.20978005
135INSR0.20681776

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.28186365
2Allograft rejection_Homo sapiens_hsa053303.03458991
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.00818190
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.00335056
5Graft-versus-host disease_Homo sapiens_hsa053322.99966125
6Staphylococcus aureus infection_Homo sapiens_hsa051502.91803337
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.77741726
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.70202579
9Measles_Homo sapiens_hsa051622.63443965
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.44364762
11Pertussis_Homo sapiens_hsa051332.31679573
12Legionellosis_Homo sapiens_hsa051342.27671605
13Influenza A_Homo sapiens_hsa051642.26838588
14Malaria_Homo sapiens_hsa051442.24062354
15Osteoclast differentiation_Homo sapiens_hsa043802.22488660
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21338528
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.15972379
18Herpes simplex infection_Homo sapiens_hsa051682.09202236
19Cyanoamino acid metabolism_Homo sapiens_hsa004602.09066568
20TNF signaling pathway_Homo sapiens_hsa046682.05270289
21Primary immunodeficiency_Homo sapiens_hsa053402.00206492
22Tuberculosis_Homo sapiens_hsa051521.89566703
23Type I diabetes mellitus_Homo sapiens_hsa049401.83957349
24Sulfur metabolism_Homo sapiens_hsa009201.80365574
25Toxoplasmosis_Homo sapiens_hsa051451.78726682
26Antigen processing and presentation_Homo sapiens_hsa046121.76100509
27Asthma_Homo sapiens_hsa053101.73597371
28African trypanosomiasis_Homo sapiens_hsa051431.73138901
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.66049059
30Rheumatoid arthritis_Homo sapiens_hsa053231.64355762
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.62359057
32B cell receptor signaling pathway_Homo sapiens_hsa046621.59425138
33Autoimmune thyroid disease_Homo sapiens_hsa053201.53167310
34Salmonella infection_Homo sapiens_hsa051321.50927499
35Chemokine signaling pathway_Homo sapiens_hsa040621.47252333
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46586031
37Viral myocarditis_Homo sapiens_hsa054161.45139151
38Fat digestion and absorption_Homo sapiens_hsa049751.41118940
39Hematopoietic cell lineage_Homo sapiens_hsa046401.40524292
40Hepatitis C_Homo sapiens_hsa051601.38302383
41Apoptosis_Homo sapiens_hsa042101.33332953
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33008218
43Chemical carcinogenesis_Homo sapiens_hsa052041.30558498
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.22594209
45Starch and sucrose metabolism_Homo sapiens_hsa005001.21485849
46Hepatitis B_Homo sapiens_hsa051611.20855734
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19890182
48Shigellosis_Homo sapiens_hsa051311.19836740
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18273162
50Lysosome_Homo sapiens_hsa041421.14999179
51Histidine metabolism_Homo sapiens_hsa003401.09801091
52Drug metabolism - other enzymes_Homo sapiens_hsa009831.09729794
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09625791
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.06739718
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06427977
56Caffeine metabolism_Homo sapiens_hsa002321.06396198
57Phagosome_Homo sapiens_hsa041451.06314756
58Protein digestion and absorption_Homo sapiens_hsa049741.04337573
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99986767
60Retinol metabolism_Homo sapiens_hsa008300.97446482
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.92389275
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91900533
63Linoleic acid metabolism_Homo sapiens_hsa005910.91516642
64Galactose metabolism_Homo sapiens_hsa000520.91457931
65Arachidonic acid metabolism_Homo sapiens_hsa005900.90412599
66Other glycan degradation_Homo sapiens_hsa005110.88802312
67T cell receptor signaling pathway_Homo sapiens_hsa046600.84121229
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.83732535
69Amoebiasis_Homo sapiens_hsa051460.82961085
70Complement and coagulation cascades_Homo sapiens_hsa046100.82542211
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80387436
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79539946
73Prolactin signaling pathway_Homo sapiens_hsa049170.77654233
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.76614201
75Acute myeloid leukemia_Homo sapiens_hsa052210.74861036
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.71413775
77Prion diseases_Homo sapiens_hsa050200.70442939
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69700005
79Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69004698
80Platelet activation_Homo sapiens_hsa046110.63222966
81Fructose and mannose metabolism_Homo sapiens_hsa000510.60465489
82Small cell lung cancer_Homo sapiens_hsa052220.60334909
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59211964
84Sphingolipid metabolism_Homo sapiens_hsa006000.57075899
85HIF-1 signaling pathway_Homo sapiens_hsa040660.57056494
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56292758
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56160524
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53958825
89Chronic myeloid leukemia_Homo sapiens_hsa052200.53459046
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53401222
91Pancreatic cancer_Homo sapiens_hsa052120.52668268
92Glycerolipid metabolism_Homo sapiens_hsa005610.52241437
93Epstein-Barr virus infection_Homo sapiens_hsa051690.51795375
94Bile secretion_Homo sapiens_hsa049760.50568810
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50493619
96Notch signaling pathway_Homo sapiens_hsa043300.44884891
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.44759902
98Tryptophan metabolism_Homo sapiens_hsa003800.43857203
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40756513
100Pancreatic secretion_Homo sapiens_hsa049720.40163706
101Viral carcinogenesis_Homo sapiens_hsa052030.39704125
102Insulin resistance_Homo sapiens_hsa049310.39075446
103Fatty acid degradation_Homo sapiens_hsa000710.37570976
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36277147
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.34560029
106HTLV-I infection_Homo sapiens_hsa051660.33302713
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33231194
108Phenylalanine metabolism_Homo sapiens_hsa003600.32757176
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31976596
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31378805
111Glutathione metabolism_Homo sapiens_hsa004800.31378267
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.24047720
113Focal adhesion_Homo sapiens_hsa045100.22758349
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21999227
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21825144
116Proteoglycans in cancer_Homo sapiens_hsa052050.20853216
117Type II diabetes mellitus_Homo sapiens_hsa049300.17650358
118Proteasome_Homo sapiens_hsa030500.15405449
119Renin-angiotensin system_Homo sapiens_hsa046140.14347581
120VEGF signaling pathway_Homo sapiens_hsa043700.14265038
121Dorso-ventral axis formation_Homo sapiens_hsa043200.14060593
122Arginine biosynthesis_Homo sapiens_hsa002200.13798892
123MicroRNAs in cancer_Homo sapiens_hsa052060.12333944
124ABC transporters_Homo sapiens_hsa020100.12288442
125PPAR signaling pathway_Homo sapiens_hsa033200.11679241
126Prostate cancer_Homo sapiens_hsa052150.11070050
127FoxO signaling pathway_Homo sapiens_hsa040680.09177104
128p53 signaling pathway_Homo sapiens_hsa041150.08441003
129Mineral absorption_Homo sapiens_hsa049780.07759150
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07617970
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.06557245
132Vitamin digestion and absorption_Homo sapiens_hsa049770.05457197

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