GBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of T-helper 1 cell differentiation (GO:0045625)5.46656934
2type I interferon signaling pathway (GO:0060337)5.43741671
3cellular response to type I interferon (GO:0071357)5.43741671
4response to type I interferon (GO:0034340)5.36954215
5positive regulation of type 2 immune response (GO:0002830)4.92965051
6negative regulation of interleukin-12 production (GO:0032695)4.69748817
7regulation of chronic inflammatory response (GO:0002676)4.55689517
8regulation of T cell tolerance induction (GO:0002664)4.52034035
9regulation of interferon-alpha production (GO:0032647)4.43223434
10regulation of dendritic cell antigen processing and presentation (GO:0002604)4.36817435
11positive regulation of gamma-delta T cell activation (GO:0046645)4.30234539
12response to peptidoglycan (GO:0032494)4.22330894
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17095374
14* interferon-gamma-mediated signaling pathway (GO:0060333)4.14874325
15regulation of vitamin D biosynthetic process (GO:0060556)4.12032157
16positive regulation of interferon-alpha production (GO:0032727)4.11074166
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.08569158
18macrophage activation involved in immune response (GO:0002281)4.00179913
19negative regulation of cell killing (GO:0031342)3.95951523
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.95951523
21regulation of tolerance induction (GO:0002643)3.95764759
22lipopolysaccharide-mediated signaling pathway (GO:0031663)3.89696609
23positive regulation of tolerance induction (GO:0002645)3.89640812
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.80293317
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.80293317
26modulation by symbiont of host immune response (GO:0052553)3.80293317
27positive regulation by symbiont of host defense response (GO:0052509)3.80293317
28modulation by symbiont of host defense response (GO:0052031)3.80293317
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.80293317
30immunoglobulin mediated immune response (GO:0016064)3.79684591
31negative regulation of viral genome replication (GO:0045071)3.79599304
32antigen processing and presentation of endogenous antigen (GO:0019883)3.77452681
33production of molecular mediator involved in inflammatory response (GO:0002532)3.76188308
34cellular response to interferon-alpha (GO:0035457)3.70948495
35response to interferon-beta (GO:0035456)3.70548621
36T cell migration (GO:0072678)3.70180010
37T-helper 1 type immune response (GO:0042088)3.69016776
38regulation of type 2 immune response (GO:0002828)3.66986841
39antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.66586039
40response to interferon-alpha (GO:0035455)3.64003751
41regulation of interleukin-12 production (GO:0032655)3.62415656
42detection of molecule of bacterial origin (GO:0032490)3.61579040
43regulation of interferon-beta biosynthetic process (GO:0045357)3.61002397
44positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.59765559
45defense response to protozoan (GO:0042832)3.53178391
46positive regulation of T-helper cell differentiation (GO:0045624)3.52927936
47positive regulation of interleukin-12 production (GO:0032735)3.49587314
48positive regulation of antigen processing and presentation (GO:0002579)3.46664658
49lymphocyte chemotaxis (GO:0048247)3.44015440
50regulation of type I interferon-mediated signaling pathway (GO:0060338)3.43772570
51myeloid dendritic cell differentiation (GO:0043011)3.43123378
52regulation of antigen processing and presentation (GO:0002577)3.42633776
53regulation of T-helper cell differentiation (GO:0045622)3.41515051
54positive regulation of cAMP-mediated signaling (GO:0043950)3.41410075
55cellular response to interferon-beta (GO:0035458)3.41221181
56positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.39557058
57regulation of vitamin metabolic process (GO:0030656)3.39478050
58NIK/NF-kappaB signaling (GO:0038061)3.37560823
59regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33240505
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32447006
61detection of other organism (GO:0098543)3.27952331
62* cellular response to interferon-gamma (GO:0071346)3.27875611
63positive regulation of interferon-beta production (GO:0032728)3.27537252
64response to protozoan (GO:0001562)3.26008381
65positive regulation of defense response to virus by host (GO:0002230)3.25454315
66positive regulation of interleukin-1 beta secretion (GO:0050718)3.24569025
67positive regulation of toll-like receptor signaling pathway (GO:0034123)3.23306436
68regulation of interleukin-1 beta secretion (GO:0050706)3.22994454
69* response to interferon-gamma (GO:0034341)3.22464871
70positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.17916947
71interferon-gamma secretion (GO:0072643)3.10218089
72regulation of cytokine secretion involved in immune response (GO:0002739)3.08853955
73regulation of gamma-delta T cell activation (GO:0046643)3.08806199
74regulation of regulatory T cell differentiation (GO:0045589)3.06737798
75regulation of interleukin-12 biosynthetic process (GO:0045075)3.06218349
76positive regulation of interleukin-1 secretion (GO:0050716)3.05942076
77* defense response to virus (GO:0051607)3.03922351
78positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.03284949
79detection of external biotic stimulus (GO:0098581)3.02643438
80kynurenine metabolic process (GO:0070189)3.02273207
81B cell mediated immunity (GO:0019724)3.00962520
82neutrophil activation involved in immune response (GO:0002283)3.00861633
83regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.00722564
84myeloid dendritic cell activation (GO:0001773)2.99950661
85dendritic cell differentiation (GO:0097028)2.99329089
86regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97251250
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.97175100
88regulation of response to interferon-gamma (GO:0060330)2.96984688
89indole-containing compound catabolic process (GO:0042436)2.96828042
90indolalkylamine catabolic process (GO:0046218)2.96828042
91tryptophan catabolic process (GO:0006569)2.96828042
92negative regulation of T cell mediated immunity (GO:0002710)2.96030777
93detection of bacterium (GO:0016045)2.95051755
94negative regulation of cytokine production involved in immune response (GO:0002719)2.94547172
95positive regulation of NF-kappaB import into nucleus (GO:0042346)2.94265620
96regulation of interleukin-1 secretion (GO:0050704)2.93245471
97regulation of RIG-I signaling pathway (GO:0039535)2.92496493
98regulation of mononuclear cell migration (GO:0071675)2.92465064
99germinal center formation (GO:0002467)2.92172320
100positive regulation of chemokine biosynthetic process (GO:0045080)2.91880749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human8.15756406
2* IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.97678489
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.28927549
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.85146223
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.58959809
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.14143820
7* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.72327308
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.62391814
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.60985985
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.27582946
11* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.01808885
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.98977506
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97151971
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.88091051
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.64265235
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63238994
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59375710
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39023804
19GATA1_22025678_ChIP-Seq_K562_Human2.36496641
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.27731510
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13451309
22RUNX_20019798_ChIP-Seq_JUKART_Human2.04737008
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98394449
24VDR_24787735_ChIP-Seq_THP-1_Human1.85068463
25MYB_26560356_Chip-Seq_TH2_Human1.84931927
26SPI1_23547873_ChIP-Seq_NB4_Human1.64448068
27MAF_26560356_Chip-Seq_TH1_Human1.61136662
28SPI1_23127762_ChIP-Seq_K562_Human1.60240690
29BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59504018
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59324179
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58885447
32VDR_24763502_ChIP-Seq_THP-1_Human1.56630096
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55627746
34PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51574356
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50004987
36MYB_26560356_Chip-Seq_TH1_Human1.45458436
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.41635103
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39387799
39SCL_19346495_ChIP-Seq_HPC-7_Human1.37762888
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31449607
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.31445440
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.31113908
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29953453
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29286338
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26772721
46GATA3_26560356_Chip-Seq_TH2_Human1.24546790
47PU_27001747_Chip-Seq_BMDM_Mouse1.22351146
48GATA3_27048872_Chip-Seq_THYMUS_Human1.21804321
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16201108
50EGR1_19032775_ChIP-ChIP_M12_Human1.15612135
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12479409
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.10092080
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09557053
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06965947
55VDR_21846776_ChIP-Seq_THP-1_Human1.04478513
56UTX_26944678_Chip-Seq_JUKART_Human1.03965946
57* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02927322
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02599550
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02345559
60CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99192183
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99092187
62KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98128560
63GATA1_19941827_ChIP-Seq_MEL_Mouse0.97896257
64MAF_26560356_Chip-Seq_TH2_Human0.97117982
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96630118
66PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88861939
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88593301
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.88282719
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88002827
70GATA1_19941826_ChIP-Seq_K562_Human0.87495662
71TCF7_22412390_ChIP-Seq_EML_Mouse0.86598669
72ELK3_25401928_ChIP-Seq_HUVEC_Human0.85421394
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.83959615
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83802767
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83770381
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82313192
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79764340
78KDM2B_26808549_Chip-Seq_DND41_Human0.79186169
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.77598948
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.77359361
81SOX2_20726797_ChIP-Seq_SW620_Human0.77234163
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76983421
83RXR_22158963_ChIP-Seq_LIVER_Mouse0.76692834
84LXR_22158963_ChIP-Seq_LIVER_Mouse0.73848733
85* STAT1_20625510_ChIP-Seq_HELA_Human0.72940915
86PPARA_22158963_ChIP-Seq_LIVER_Mouse0.72277820
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.71639343
88CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67309669
89ESR1_21235772_ChIP-Seq_MCF-7_Human0.66150036
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.65426050
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65421807
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.64366878
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.64366878
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.64025566
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.62906234
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61293505
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.60962096
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60457900
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.60270337
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.60059739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.80671322
2MP0003724_increased_susceptibility_to4.50750113
3MP0001835_abnormal_antigen_presentation4.29749225
4MP0009785_altered_susceptibility_to3.84809786
5MP0006082_CNS_inflammation3.70735359
6MP0002148_abnormal_hypersensitivity_rea3.39603726
7MP0003436_decreased_susceptibility_to3.28735943
8MP0005671_abnormal_response_to3.07745046
9MP0005387_immune_system_phenotype3.03728632
10MP0001790_abnormal_immune_system3.03728632
11MP0005000_abnormal_immune_tolerance2.95624027
12MP0005025_abnormal_response_to2.82673374
13MP0000685_abnormal_immune_system2.75388896
14MP0001800_abnormal_humoral_immune2.67427834
15MP0002419_abnormal_innate_immunity2.56093057
16MP0003300_gastrointestinal_ulcer2.48606548
17MP0002723_abnormal_immune_serum2.47115674
18MP0002452_abnormal_antigen_presenting2.45119337
19MP0004510_myositis2.31495555
20MP0010155_abnormal_intestine_physiology2.16545255
21MP0009764_decreased_sensitivity_to2.12830333
22MP0001533_abnormal_skeleton_physiology2.12672670
23MP0004947_skin_inflammation2.09528114
24MP0001819_abnormal_immune_cell2.03586730
25MP0002420_abnormal_adaptive_immunity2.00860557
26MP0005451_abnormal_body_composition1.98678545
27MP0001845_abnormal_inflammatory_respons1.94790855
28MP0003448_altered_tumor_morphology1.75021802
29MP0008469_abnormal_protein_level1.73726582
30MP0003075_altered_response_to1.73117890
31MP0002405_respiratory_system_inflammati1.69347346
32MP0005058_abnormal_lysosome_morphology1.68488769
33MP0009333_abnormal_splenocyte_physiolog1.61447028
34MP0000343_altered_response_to1.56389655
35MP0005310_abnormal_salivary_gland1.55998316
36MP0006054_spinal_hemorrhage1.53398902
37MP0000716_abnormal_immune_system1.50011226
38MP0001853_heart_inflammation1.44816877
39MP0003763_abnormal_thymus_physiology1.43419168
40MP0002139_abnormal_hepatobiliary_system1.42877095
41MP0003191_abnormal_cellular_cholesterol1.42841329
42MP0008004_abnormal_stomach_pH1.42734544
43MP0002332_abnormal_exercise_endurance1.41123164
44MP0000858_altered_metastatic_potential1.39443095
45MP0002254_reproductive_system_inflammat1.38857197
46MP0005166_decreased_susceptibility_to1.36184229
47MP0000604_amyloidosis1.34079465
48MP0002398_abnormal_bone_marrow1.31924524
49MP0003195_calcinosis1.31087709
50MP0002998_abnormal_bone_remodeling1.28964648
51MP0005164_abnormal_response_to1.28681237
52MP0003172_abnormal_lysosome_physiology1.27782203
53MP0009840_abnormal_foam_cell1.27126654
54MP0009278_abnormal_bone_marrow1.23126784
55MP0002166_altered_tumor_susceptibility1.21885435
56MP0003453_abnormal_keratinocyte_physiol1.16322285
57MP0008260_abnormal_autophagy1.16313737
58MP0001545_abnormal_hematopoietic_system1.15859007
59MP0005397_hematopoietic_system_phenotyp1.15859007
60MP0005464_abnormal_platelet_physiology1.14655379
61MP0002429_abnormal_blood_cell1.12213698
62MP0004883_abnormal_blood_vessel1.12001301
63MP0002138_abnormal_hepatobiliary_system1.10591774
64MP0009763_increased_sensitivity_to1.10564330
65MP0003690_abnormal_glial_cell1.07566111
66MP0003806_abnormal_nucleotide_metabolis1.07197362
67MP0002006_tumorigenesis1.05344092
68MP0000689_abnormal_spleen_morphology1.02514388
69MP0002722_abnormal_immune_system1.02247878
70MP0005390_skeleton_phenotype0.99369741
71MP0003091_abnormal_cell_migration0.97565950
72MP0005167_abnormal_blood-brain_barrier0.96250470
73MP0009765_abnormal_xenobiotic_induced0.92239786
74MP0003183_abnormal_peptide_metabolism0.91420004
75MP0003866_abnormal_defecation0.88556100
76MP0003656_abnormal_erythrocyte_physiolo0.83348469
77MP0002933_joint_inflammation0.81551643
78MP0002277_abnormal_respiratory_mucosa0.79751647
79MP0001542_abnormal_bone_strength0.79117332
80MP0001873_stomach_inflammation0.78653956
81MP0001663_abnormal_digestive_system0.78064098
82MP0005023_abnormal_wound_healing0.76281770
83MP0003045_fibrosis0.75818635
84MP0003221_abnormal_cardiomyocyte_apopto0.72606399
85MP0003828_pulmonary_edema0.70848803
86MP0000249_abnormal_blood_vessel0.70840916
87MP0001851_eye_inflammation0.69869588
88MP0000465_gastrointestinal_hemorrhage0.69202527
89MP0008874_decreased_physiological_sensi0.69119996
90MP0004808_abnormal_hematopoietic_stem0.67901650
91MP0005165_increased_susceptibility_to0.67769293
92MP0010352_gastrointestinal_tract_polyps0.67191271
93MP0003795_abnormal_bone_structure0.66162330
94MP0000920_abnormal_myelination0.65288387
95MP0001348_abnormal_lacrimal_gland0.64678970
96MP0003646_muscle_fatigue0.62982358
97MP0000703_abnormal_thymus_morphology0.62279516
98MP0002877_abnormal_melanocyte_morpholog0.60130919
99MP0001501_abnormal_sleep_pattern0.56080598
100MP0005319_abnormal_enzyme/_coenzyme0.55959994

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)6.19887378
2Optic neuritis (HP:0100653)6.19887378
3Orchitis (HP:0100796)6.05408106
4Myositis (HP:0100614)5.43442060
5Recurrent bacterial skin infections (HP:0005406)4.80623839
6Eczematoid dermatitis (HP:0000976)4.75657154
7Abnormality of macrophages (HP:0004311)4.54379242
8Keratoconjunctivitis sicca (HP:0001097)4.38201890
9Recurrent abscess formation (HP:0002722)4.31372606
10Abnormality of liposaccharide metabolism (HP:0010968)4.23105284
11Abnormality of glycosphingolipid metabolism (HP:0004343)4.23105284
12Abnormality of glycolipid metabolism (HP:0010969)4.23105284
13Stomatitis (HP:0010280)4.22397658
14Systemic lupus erythematosus (HP:0002725)4.19677023
15Gastrointestinal infarctions (HP:0005244)4.18831449
16Keratoconjunctivitis (HP:0001096)4.05376803
17Elevated erythrocyte sedimentation rate (HP:0003565)3.93488642
18Increased IgM level (HP:0003496)3.89621695
19Mediastinal lymphadenopathy (HP:0100721)3.80402107
20Pulmonary infiltrates (HP:0002113)3.71138978
21Hemoptysis (HP:0002105)3.68884043
22Vasculitis (HP:0002633)3.65658054
23Recurrent fungal infections (HP:0002841)3.46876276
24Abnormality of T cell number (HP:0011839)3.44376555
25T lymphocytopenia (HP:0005403)3.41290706
26Recurrent skin infections (HP:0001581)3.38473553
27Recurrent gram-negative bacterial infections (HP:0005420)3.35386308
28Chronic mucocutaneous candidiasis (HP:0002728)3.32765023
29Recurrent cutaneous fungal infections (HP:0011370)3.32765023
30Gangrene (HP:0100758)3.30454687
31Autoimmune thrombocytopenia (HP:0001973)3.26345259
32Recurrent viral infections (HP:0004429)3.23336787
33Arterial thrombosis (HP:0004420)3.15453420
34Encephalitis (HP:0002383)3.14355202
35Autoimmune hemolytic anemia (HP:0001890)3.11221778
36Hypergammaglobulinemia (HP:0010702)3.01261088
37Peritonitis (HP:0002586)3.00198332
38Loss of speech (HP:0002371)2.93573372
39Meningitis (HP:0001287)2.85361902
40Recurrent bronchitis (HP:0002837)2.84201230
41Chronic otitis media (HP:0000389)2.80701649
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.80565458
43Leukocytosis (HP:0001974)2.76814050
44Interstitial pulmonary disease (HP:0006530)2.73280877
45Gingivitis (HP:0000230)2.72836005
46Dysostosis multiplex (HP:0000943)2.72433672
47Anorexia (HP:0002039)2.69417581
48Hematochezia (HP:0002573)2.66479851
49Vacuolated lymphocytes (HP:0001922)2.64568651
50Amyloidosis (HP:0011034)2.55465732
51Abnormality of the pleura (HP:0002103)2.53263558
52Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.52846126
53Obstructive lung disease (HP:0006536)2.51343529
54Chronic obstructive pulmonary disease (HP:0006510)2.51343529
55Nasal polyposis (HP:0100582)2.49202503
56Pulmonary embolism (HP:0002204)2.48603306
57Abnormality of the nasal mucosa (HP:0000433)2.43026657
58Chest pain (HP:0100749)2.42057795
59Increased IgE level (HP:0003212)2.41776458
60Glomerulonephritis (HP:0000099)2.41050717
61Disinhibition (HP:0000734)2.40886386
62Joint swelling (HP:0001386)2.39901340
63Urticaria (HP:0001025)2.39150013
64Abnormality of the endocardium (HP:0004306)2.37888337
65Abnormality of the pericardium (HP:0001697)2.36994716
66Polyneuropathy (HP:0001271)2.33193231
67Eosinophilia (HP:0001880)2.31410941
68Increased cerebral lipofuscin (HP:0011813)2.30205257
69Malnutrition (HP:0004395)2.24469112
70Abnormality of T cells (HP:0002843)2.23480791
71Glomerulopathy (HP:0100820)2.21896611
72Episodic fever (HP:0001954)2.21444199
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19292210
74Abnormality of polysaccharide metabolism (HP:0011012)2.19292210
75Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19292210
76Vertigo (HP:0002321)2.18634454
77Keratitis (HP:0000491)2.18380867
78Acne (HP:0001061)2.15736437
79Premature loss of primary teeth (HP:0006323)2.13787651
80Colitis (HP:0002583)2.13279220
81Myocardial infarction (HP:0001658)2.12914081
82Abnormality of B cell number (HP:0010975)2.12468067
83Mucopolysacchariduria (HP:0008155)2.11890114
84Urinary glycosaminoglycan excretion (HP:0003541)2.11890114
85Purpura (HP:0000979)2.10694982
86Gingival bleeding (HP:0000225)2.10522903
87Basal ganglia calcification (HP:0002135)2.07936993
88Granulocytopenia (HP:0001913)2.07149131
89Increased serum ferritin (HP:0003281)2.06008574
90Parakeratosis (HP:0001036)2.03447287
91Progressive neurologic deterioration (HP:0002344)2.03319570
92Amaurosis fugax (HP:0100576)2.02445746
93Abnormality of the peritoneum (HP:0002585)2.01206900
94Arthralgia (HP:0002829)1.99793100
95Spontaneous hematomas (HP:0007420)1.98294914
96Thoracolumbar scoliosis (HP:0002944)1.96520053
97Complement deficiency (HP:0004431)1.95761687
98Alveolar cell carcinoma (HP:0006519)1.95692749
99Abnormality of eosinophils (HP:0001879)1.93490807
100IgA deficiency (HP:0002720)1.91410778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK24.77331417
2IRAK33.49380215
3MAP3K143.27899502
4IKBKE3.26815135
5JAK33.05322925
6GRK73.02752348
7FGFR42.94677331
8TXK2.92631648
9RIPK42.80975650
10JAK12.76335525
11TBK12.57164051
12MAP4K12.57160635
13IRAK42.50175427
14RIPK12.43285440
15BLK2.23353378
16MATK2.21981104
17CSK2.17068172
18PRPF4B2.06653852
19DDR22.00069171
20KIT1.99534850
21IKBKB1.88227572
22TAOK21.83584951
23FGFR31.80720817
24ERN11.73605579
25FGR1.66940776
26BMPR21.65875208
27ZAP701.60985319
28MAP3K31.47635417
29JAK21.45162459
30CDC42BPA1.39931043
31EPHA31.38778254
32ADRBK21.35548697
33IRAK11.33685408
34MAP2K31.26039757
35EPHB11.19153059
36TAOK11.15857350
37SYK1.15091026
38LYN1.12777543
39MAP3K111.10104560
40MAP3K131.08323472
41TGFBR21.07739931
42CHUK1.05404644
43LCK1.01690910
44HCK0.99958766
45MOS0.98293735
46PIM20.97949744
47BTK0.94489610
48MAP3K10.91243198
49SIK30.87687122
50TAOK30.80942053
51IRAK20.80529294
52NME20.80067415
53FES0.80003509
54HIPK20.73479482
55MAP3K50.73476024
56STK100.71806698
57CSF1R0.67140839
58TYRO30.65672878
59TNK20.61070496
60MAPK110.60399024
61ITK0.60350559
62CLK10.59802746
63NLK0.57538893
64TESK20.55852976
65MARK30.52277422
66PIM10.49703733
67TEC0.48376267
68EGFR0.38961258
69MAP2K60.37190925
70PDGFRA0.37186659
71DYRK30.37109583
72ACVR1B0.36981531
73MAPK70.36793903
74PDGFRB0.35686732
75CDK60.33961155
76PDK10.33410375
77ABL10.31735894
78MAPKAPK20.30515442
79FYN0.30324261
80PRKCD0.29674364
81GRK60.25137852
82STK240.24859197
83BMX0.24657272
84AKT30.24458304
85INSR0.24099774
86PRKCQ0.23472541
87MAPK40.23118776
88PDPK10.22877991
89EIF2AK20.22407574
90CDK40.22203349
91YES10.21377300
92MAP3K60.20302884
93RPS6KA50.19715644
94PKN10.19289066
95NEK90.19185822
96SGK30.18615007
97PIK3CG0.18052608
98KSR20.17237275
99DAPK20.17005018
100LRRK20.16412061

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.36009405
2Toll-like receptor signaling pathway_Homo sapiens_hsa046203.16073269
3Graft-versus-host disease_Homo sapiens_hsa053322.86497803
4Autoimmune thyroid disease_Homo sapiens_hsa053202.79362908
5Leishmaniasis_Homo sapiens_hsa051402.77052760
6Staphylococcus aureus infection_Homo sapiens_hsa051502.64616777
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.62003513
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.58324615
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.56912345
10Osteoclast differentiation_Homo sapiens_hsa043802.52996113
11Asthma_Homo sapiens_hsa053102.49933334
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.39566985
13Type I diabetes mellitus_Homo sapiens_hsa049402.28767910
14African trypanosomiasis_Homo sapiens_hsa051432.28404400
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.18522814
16Influenza A_Homo sapiens_hsa051642.14827761
17Malaria_Homo sapiens_hsa051442.10605032
18Measles_Homo sapiens_hsa051622.10040723
19Rheumatoid arthritis_Homo sapiens_hsa053232.09150858
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.04956311
21TNF signaling pathway_Homo sapiens_hsa046682.02086444
22Tuberculosis_Homo sapiens_hsa051521.96196191
23Pertussis_Homo sapiens_hsa051331.95071304
24Antigen processing and presentation_Homo sapiens_hsa046121.85792667
25Legionellosis_Homo sapiens_hsa051341.79880899
26Toxoplasmosis_Homo sapiens_hsa051451.79524586
27Herpes simplex infection_Homo sapiens_hsa051681.77263211
28Primary immunodeficiency_Homo sapiens_hsa053401.67858732
29Hepatitis C_Homo sapiens_hsa051601.58968598
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.58246280
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57385809
32Viral myocarditis_Homo sapiens_hsa054161.56753413
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.50233954
34Other glycan degradation_Homo sapiens_hsa005111.46810538
35Chemokine signaling pathway_Homo sapiens_hsa040621.45202720
36Hematopoietic cell lineage_Homo sapiens_hsa046401.41273183
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31388653
38B cell receptor signaling pathway_Homo sapiens_hsa046621.26397212
39Hepatitis B_Homo sapiens_hsa051611.25857378
40Lysosome_Homo sapiens_hsa041421.24288574
41Salmonella infection_Homo sapiens_hsa051321.23346249
42T cell receptor signaling pathway_Homo sapiens_hsa046601.09019489
43Phagosome_Homo sapiens_hsa041451.08817433
44Shigellosis_Homo sapiens_hsa051310.97931131
45Apoptosis_Homo sapiens_hsa042100.96183503
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94798415
47Prolactin signaling pathway_Homo sapiens_hsa049170.91666667
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88597767
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.87617527
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85920143
51Acute myeloid leukemia_Homo sapiens_hsa052210.85316563
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83699709
53Amoebiasis_Homo sapiens_hsa051460.78794617
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78570293
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77206911
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.77098124
57Epstein-Barr virus infection_Homo sapiens_hsa051690.70294298
58Complement and coagulation cascades_Homo sapiens_hsa046100.66463577
59Prion diseases_Homo sapiens_hsa050200.65189216
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59724239
61Pancreatic cancer_Homo sapiens_hsa052120.53515436
62Bladder cancer_Homo sapiens_hsa052190.51127928
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49664048
64Tryptophan metabolism_Homo sapiens_hsa003800.49334370
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.45134534
66HTLV-I infection_Homo sapiens_hsa051660.43730995
67VEGF signaling pathway_Homo sapiens_hsa043700.42108393
68Dorso-ventral axis formation_Homo sapiens_hsa043200.40033068
69Viral carcinogenesis_Homo sapiens_hsa052030.36248718
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.35894472
71Chronic myeloid leukemia_Homo sapiens_hsa052200.34110971
72Sulfur metabolism_Homo sapiens_hsa009200.33774685
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33643698
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33553389
75Systemic lupus erythematosus_Homo sapiens_hsa053220.33210280
76Type II diabetes mellitus_Homo sapiens_hsa049300.32670597
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32588420
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.31952838
79Platelet activation_Homo sapiens_hsa046110.30801604
80Insulin resistance_Homo sapiens_hsa049310.29394407
81HIF-1 signaling pathway_Homo sapiens_hsa040660.27173152
82FoxO signaling pathway_Homo sapiens_hsa040680.27142804
83Sphingolipid metabolism_Homo sapiens_hsa006000.26140462
84Notch signaling pathway_Homo sapiens_hsa043300.25923072
85Endocytosis_Homo sapiens_hsa041440.21882618
86Renal cell carcinoma_Homo sapiens_hsa052110.18073928
87Non-small cell lung cancer_Homo sapiens_hsa052230.16269529
88Small cell lung cancer_Homo sapiens_hsa052220.16021426
89Mineral absorption_Homo sapiens_hsa049780.15067391
90Collecting duct acid secretion_Homo sapiens_hsa049660.14467064
91MAPK signaling pathway_Homo sapiens_hsa040100.12329065
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11881519
93Proteoglycans in cancer_Homo sapiens_hsa052050.11104528
94Prostate cancer_Homo sapiens_hsa052150.10078818
95PPAR signaling pathway_Homo sapiens_hsa033200.09661316
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.09551971
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08924393
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.06323363
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.05827839
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.03919660

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