GBGT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a glycosyltransferase that plays a role in the synthesis of Forssman glycolipid (FG), a member of the globoseries glycolipid family. Glycolipids such as FG form attachment sites for the binding of pathogens to cells; expression of this protein may determine host tropism to microorganisms. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.63097012
2maintenance of protein location in nucleus (GO:0051457)7.13929648
3somite rostral/caudal axis specification (GO:0032525)6.69283080
4regulation of response to osmotic stress (GO:0047484)6.63526235
5regulation of mammary gland epithelial cell proliferation (GO:0033599)6.49139998
6negative regulation of epidermis development (GO:0045683)6.36707773
7negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.24476000
8positive regulation of gamma-delta T cell activation (GO:0046645)5.83574184
9muscle organ morphogenesis (GO:0048644)5.83357265
10protein localization to kinetochore (GO:0034501)5.73740528
11regulation of telomere maintenance via telomerase (GO:0032210)5.68213499
12regulation of MHC class I biosynthetic process (GO:0045343)5.62915869
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.59341130
14regulation of nuclear cell cycle DNA replication (GO:0033262)5.57790924
15negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.53548947
16negative regulation of telomerase activity (GO:0051974)5.52773356
17histone H4-K5 acetylation (GO:0043981)5.43818494
18histone H4-K8 acetylation (GO:0043982)5.43818494
19histone H4-K12 acetylation (GO:0043983)5.36728565
20cytidine deamination (GO:0009972)5.36705412
21cytidine metabolic process (GO:0046087)5.36705412
22cytidine catabolic process (GO:0006216)5.36705412
23rRNA transcription (GO:0009303)5.28272793
24negative regulation of erythrocyte differentiation (GO:0045647)5.23711646
25response to peptidoglycan (GO:0032494)5.14176476
26positive regulation by symbiont of host defense response (GO:0052509)5.07998894
27modulation by symbiont of host defense response (GO:0052031)5.07998894
28modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.07998894
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.07998894
30positive regulation by organism of defense response of other organism involved in symbiotic interact5.07998894
31modulation by symbiont of host immune response (GO:0052553)5.07998894
32hormone catabolic process (GO:0042447)5.05168994
33negative regulation of interleukin-12 production (GO:0032695)5.03546556
34neutrophil activation involved in immune response (GO:0002283)5.01262198
35phenol-containing compound catabolic process (GO:0019336)4.87139024
36negative regulation of epidermal cell differentiation (GO:0045605)4.83969331
37regulation of cilium movement (GO:0003352)4.77187977
38response to dietary excess (GO:0002021)4.75961656
39interferon-gamma production (GO:0032609)4.73183429
40notochord development (GO:0030903)4.67576460
41heterochromatin organization (GO:0070828)4.62636952
42cellular extravasation (GO:0045123)4.56152320
43mitotic sister chromatid segregation (GO:0000070)4.53043337
44coenzyme catabolic process (GO:0009109)4.49194490
45nucleoside transmembrane transport (GO:1901642)4.46692348
46primitive streak formation (GO:0090009)4.37374233
47branching involved in mammary gland duct morphogenesis (GO:0060444)4.34129054
48regulation of apoptotic process involved in morphogenesis (GO:1902337)4.31975811
49macrophage activation involved in immune response (GO:0002281)4.28770644
50regulation of mast cell degranulation (GO:0043304)4.28746471
51immunoglobulin mediated immune response (GO:0016064)4.27685346
52rRNA methylation (GO:0031167)4.26661861
53positive regulation of DNA-dependent DNA replication (GO:2000105)4.22353289
54quinone metabolic process (GO:1901661)4.12546876
55protein localization to chromosome, centromeric region (GO:0071459)4.07883509
56negative regulation of telomere maintenance (GO:0032205)4.07652388
57regulation of gamma-delta T cell activation (GO:0046643)4.06308473
58histone H4-K16 acetylation (GO:0043984)4.05448362
59cellular modified amino acid catabolic process (GO:0042219)3.99266844
60chromatin assembly (GO:0031497)3.98118115
61cellular response to thyroid hormone stimulus (GO:0097067)3.97239883
62maintenance of protein localization in organelle (GO:0072595)3.96352941
63regulation of mast cell activation involved in immune response (GO:0033006)3.95683953
64mitochondrion distribution (GO:0048311)3.95220094
65regulation of translation in response to stress (GO:0043555)3.92341006
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.85085608
67intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.82985259
68positive regulation of mast cell activation (GO:0033005)3.82541887
69detection of other organism (GO:0098543)3.81789873
70negative regulation of cell killing (GO:0031342)3.81191921
71negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.81191921
72regulation of myeloid leukocyte mediated immunity (GO:0002886)3.80849093
73nuclear pore complex assembly (GO:0051292)3.79540377
74positive regulation of B cell differentiation (GO:0045579)3.79302581
75rRNA modification (GO:0000154)3.79135282
76pyrimidine ribonucleoside catabolic process (GO:0046133)3.78876672
77positive regulation of mast cell activation involved in immune response (GO:0033008)3.78783512
78positive regulation of mast cell degranulation (GO:0043306)3.78783512
79tachykinin receptor signaling pathway (GO:0007217)3.78566590
80positive regulation of protein deacetylation (GO:0090312)3.77845616
81DNA replication-dependent nucleosome organization (GO:0034723)3.76968762
82DNA replication-dependent nucleosome assembly (GO:0006335)3.76968762
83cell fate commitment involved in formation of primary germ layer (GO:0060795)3.71326212
84sister chromatid segregation (GO:0000819)3.68807461
85epoxygenase P450 pathway (GO:0019373)3.65765126
86regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.65019080
87lipopolysaccharide-mediated signaling pathway (GO:0031663)3.64591665
88retinoic acid receptor signaling pathway (GO:0048384)3.63808029
89icosanoid secretion (GO:0032309)3.63718919
90arachidonic acid secretion (GO:0050482)3.63718919
91vitamin A metabolic process (GO:0006776)3.60877484
92regulation of leukocyte degranulation (GO:0043300)3.59350040
93detection of bacterium (GO:0016045)3.58538494
94regulation of mast cell activation (GO:0033003)3.55906975
95transepithelial transport (GO:0070633)3.55553739
96intestinal epithelial cell development (GO:0060576)3.55056590
97myeloid cell activation involved in immune response (GO:0002275)3.55022749
98detection of molecule of bacterial origin (GO:0032490)3.53423265
99bone trabecula formation (GO:0060346)3.52593422
100proline transport (GO:0015824)3.50196267
101positive regulation of histone deacetylation (GO:0031065)3.49737910
102regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.46794803
103regulation of gamma-delta T cell differentiation (GO:0045586)3.45688030
104positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.44067826
105granulocyte activation (GO:0036230)3.43850890
106detection of external biotic stimulus (GO:0098581)3.43519367
107DNA replication checkpoint (GO:0000076)3.43161967
108intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.40314284
109positive regulation of macrophage cytokine production (GO:0060907)3.39604049
110cardiovascular system development (GO:0072358)3.38807727
111regulation of interferon-beta biosynthetic process (GO:0045357)3.38716422
112mRNA stabilization (GO:0048255)3.37606797
113RNA stabilization (GO:0043489)3.37606797
114response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37202313
115response to host immune response (GO:0052572)3.37202313
116neutrophil activation (GO:0042119)3.33885933
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.32431313
118negative regulation of interleukin-2 production (GO:0032703)3.31467437
119response to muramyl dipeptide (GO:0032495)3.31391880
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.31312580
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.31178806
122phagocytosis, recognition (GO:0006910)3.30733583
123tolerance induction (GO:0002507)3.29737882
124regulation of telomerase activity (GO:0051972)3.29643841
125nucleoside transport (GO:0015858)3.29390250
126regulation of telomere maintenance (GO:0032204)3.28153946
127microtubule severing (GO:0051013)3.27521095
128hypotonic response (GO:0006971)3.27384327
129germinal center formation (GO:0002467)3.26989744
130response to protozoan (GO:0001562)3.26429323
131microglial cell activation (GO:0001774)3.25148938
132pre-miRNA processing (GO:0031054)3.24657454
133macrophage activation (GO:0042116)3.23401811
134regulation of B cell receptor signaling pathway (GO:0050855)3.20715606
135apoptotic DNA fragmentation (GO:0006309)3.19289079
136regulation of hypersensitivity (GO:0002883)3.18818492
137defense response to protozoan (GO:0042832)3.18557612
138maternal placenta development (GO:0001893)3.18152557
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.17779762
140B cell mediated immunity (GO:0019724)3.17486157
141respiratory burst (GO:0045730)3.15842820
142regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.13986525
143nuclear pore organization (GO:0006999)3.13890191
144response to thyroid hormone (GO:0097066)3.13856329
145antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13824281
146antigen processing and presentation of endogenous antigen (GO:0019883)3.12545991
147T-helper 1 type immune response (GO:0042088)3.11944194
148detection of temperature stimulus (GO:0016048)3.11906605
149GDP-mannose metabolic process (GO:0019673)3.10253316
150negative regulation of cytokine production involved in immune response (GO:0002719)3.09696765
151ventricular system development (GO:0021591)3.09467944
152cofactor transport (GO:0051181)3.07580743
153establishment of endothelial barrier (GO:0061028)3.07266240
154leukocyte degranulation (GO:0043299)3.07249173
155positive regulation of interleukin-17 production (GO:0032740)3.05489104
156detection of biotic stimulus (GO:0009595)3.04512250
157regulation of antigen processing and presentation (GO:0002577)3.03956692
158regulation of microtubule-based movement (GO:0060632)3.02546060
159protein polyglutamylation (GO:0018095)3.02034340
160negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.00823581
161trophectodermal cell differentiation (GO:0001829)3.00736822
162positive regulation of tissue remodeling (GO:0034105)3.00552562
163positive regulation of leukocyte degranulation (GO:0043302)2.99278134
164antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98328628
165response to host (GO:0075136)2.95264330
166response to host defenses (GO:0052200)2.95264330
167response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95264330
168positive regulation of antigen processing and presentation (GO:0002579)2.94212858
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90292290
170interferon-gamma-mediated signaling pathway (GO:0060333)2.89878204
171negative regulation of T cell mediated immunity (GO:0002710)2.89176821
172positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88831844
173positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.87751930
174positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.85866058
175regulation of regulated secretory pathway (GO:1903305)2.85682031
176amino sugar catabolic process (GO:0046348)2.84653424
177positive regulation of cellular amide metabolic process (GO:0034250)2.84355734
178regulation of interferon-alpha production (GO:0032647)2.84047299
179regulation of B cell differentiation (GO:0045577)2.83901045
180NIK/NF-kappaB signaling (GO:0038061)2.82966806
181regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.79771634
182positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.79600729
183regulation of erythrocyte differentiation (GO:0045646)2.77091540
184regulation of interleukin-12 production (GO:0032655)2.76095715
185glycosphingolipid catabolic process (GO:0046479)2.73980093
186N-acetylneuraminate metabolic process (GO:0006054)2.73169205
187neutrophil chemotaxis (GO:0030593)2.70590978
188regulation of interleukin-17 production (GO:0032660)2.70274094
189myeloid leukocyte activation (GO:0002274)2.69931513
190positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.69855396
191regulation of mononuclear cell migration (GO:0071675)2.65230769
192mannose metabolic process (GO:0006013)2.64973385
193positive regulation of NF-kappaB import into nucleus (GO:0042346)2.64828942
194superoxide anion generation (GO:0042554)2.64718622
195oligosaccharide catabolic process (GO:0009313)2.63907802
196myeloid dendritic cell activation (GO:0001773)2.63745436
197B cell receptor signaling pathway (GO:0050853)2.63526546
198doxorubicin metabolic process (GO:0044598)11.8277132
199daunorubicin metabolic process (GO:0044597)11.8277132
200polyketide metabolic process (GO:0030638)11.8277132

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.10419914
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.90835403
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.90835403
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.90835403
5IRF8_22096565_ChIP-ChIP_GC-B_Human5.47438276
6GATA1_22025678_ChIP-Seq_K562_Human4.77279875
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.09192776
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.36145675
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.33271510
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.27775009
11VDR_21846776_ChIP-Seq_THP-1_Human3.18305777
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15094706
13E2F7_22180533_ChIP-Seq_HELA_Human3.06400492
14TP63_19390658_ChIP-ChIP_HaCaT_Human3.04614914
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.89202911
16VDR_24763502_ChIP-Seq_THP-1_Human2.86016570
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.78311875
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.74097560
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73191504
20* SPI1_23127762_ChIP-Seq_K562_Human2.72299603
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72263705
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.69704010
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67034490
24* SPI1_23547873_ChIP-Seq_NB4_Human2.59031946
25GATA1_19941826_ChIP-Seq_K562_Human2.58442844
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.53748444
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52928051
28TCF3_18692474_ChIP-Seq_MEFs_Mouse2.46361370
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.44174020
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42078909
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.31051074
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14611956
33STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13804511
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11993832
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.10618350
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.08281089
37RUNX1_22412390_ChIP-Seq_EML_Mouse2.07425592
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.02408906
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.01187034
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.00770135
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99642621
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97915003
43VDR_24787735_ChIP-Seq_THP-1_Human1.97171281
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95523612
45RUNX_20019798_ChIP-Seq_JUKART_Human1.95014031
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93053645
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87837835
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.87821176
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86206993
50MAF_26560356_Chip-Seq_TH1_Human1.85870494
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.85566627
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.83248831
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.80977674
54GATA2_19941826_ChIP-Seq_K562_Human1.78642833
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77440104
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.74609572
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74484795
58IRF1_19129219_ChIP-ChIP_H3396_Human1.74438333
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.74228709
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73549984
61MYB_26560356_Chip-Seq_TH2_Human1.72749655
62UTX_26944678_Chip-Seq_JUKART_Human1.69983693
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68361427
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.66343162
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65454867
66CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64081398
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63943395
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.61516390
69TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.60818390
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.58487744
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55185607
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.52568600
73KDM2B_26808549_Chip-Seq_DND41_Human1.52023299
74FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49274267
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.48129614
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.47913175
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.47488681
78MYB_26560356_Chip-Seq_TH1_Human1.46020768
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45636707
80* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.45195978
81NANOG_18692474_ChIP-Seq_MEFs_Mouse1.45041844
82MAF_26560356_Chip-Seq_TH2_Human1.43784368
83PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.41042242
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37653734
85ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37242247
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.36279770
87FOXM1_23109430_ChIP-Seq_U2OS_Human1.35760965
88POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34943558
89E2F1_17053090_ChIP-ChIP_MCF-7_Human1.34870360
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34399157
91ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33734186
92PU_27001747_Chip-Seq_BMDM_Mouse1.29192581
93GATA3_27048872_Chip-Seq_THYMUS_Human1.28280701
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28233661
95* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26703824
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26623964
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25930100
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25583786
99* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24830182
100OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24727333
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24538169
102BCL6_27268052_Chip-Seq_Bcells_Human1.24012615
103* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19415163
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18844470
105SOX2_18692474_ChIP-Seq_MESCs_Mouse1.18020118
106NANOG_16518401_ChIP-PET_MESCs_Mouse1.17015794
107MYC_22102868_ChIP-Seq_BL_Human1.16946885
108TFEB_21752829_ChIP-Seq_HELA_Human1.13056577
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11333658
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.09356380
111SCL_19346495_ChIP-Seq_HPC-7_Human1.09255983
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08521537
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08404075
114FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08340605
115* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08092595
116* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07779172
117* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07444503
118GATA3_26560356_Chip-Seq_TH2_Human1.05790533
119TP53_22127205_ChIP-Seq_IMR90_Human1.05468061
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05051238
121NCOR1_26117541_ChIP-Seq_K562_Human1.03938198
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03813030
123SPI1_20517297_ChIP-Seq_HL60_Human1.03515541
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03469184
125YY1_21170310_ChIP-Seq_MESCs_Mouse1.03209436
126* TCF7_22412390_ChIP-Seq_EML_Mouse1.03155899
127STAT1_20625510_ChIP-Seq_HELA_Human1.03021547
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02916142
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02604004
130* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01796738
131* ELF1_20517297_ChIP-Seq_JURKAT_Human1.00117292
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97525056
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97376285
134STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97119951
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96354305
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94653697
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94592666
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92175320
139NANOG_16153702_ChIP-ChIP_HESCs_Human0.92033373
140ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91333828
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91317645
142RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91180455
143IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90062293
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.88651043
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.86056767
146TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85906284
147TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84922549
148CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84518388
149TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84506736
150POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84227939
151SMC4_20622854_ChIP-Seq_HELA_Human0.82314714
152NANOG_21062744_ChIP-ChIP_HESCs_Human0.81657167
153MYC_19079543_ChIP-ChIP_MESCs_Mouse0.81124220
154KDM2B_26808549_Chip-Seq_K562_Human0.80508380
155EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77346760
156LXR_22292898_ChIP-Seq_THP-1_Human0.77344305
157EGR1_19374776_ChIP-ChIP_THP-1_Human0.77339400
158ESR2_21235772_ChIP-Seq_MCF-7_Human0.76748145
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76664058
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76566459
161RACK7_27058665_Chip-Seq_MCF-7_Human0.76073698
162WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.75437625
163POU5F1_16153702_ChIP-ChIP_HESCs_Human0.74572270
164MYC_19030024_ChIP-ChIP_MESCs_Mouse0.73904838
165STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71236399
166KAP1_27257070_Chip-Seq_ESCs_Mouse0.70967637
167IRF8_21731497_ChIP-ChIP_J774_Mouse0.70227485
168* CTCF_21964334_Chip-Seq_Bcells_Human0.69197506
169THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.68818431
170* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.67162578
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.65000893
172RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.64636415
173SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.64610582
174RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.63707777
175BCOR_27268052_Chip-Seq_Bcells_Human0.63586618
176NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62945954
177CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62229328
178MYC_18555785_ChIP-Seq_MESCs_Mouse0.60990585
179ELK4_26923725_Chip-Seq_MESODERM_Mouse0.60865439
180SRY_22984422_ChIP-ChIP_TESTIS_Rat0.60256987
181KLF4_18555785_ChIP-Seq_MESCs_Mouse0.59094898

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.00331197
2MP0002254_reproductive_system_inflammat4.96795545
3MP0004264_abnormal_extraembryonic_tissu4.55087536
4MP0003303_peritoneal_inflammation4.46525590
5MP0006292_abnormal_olfactory_placode4.10483987
6MP0004858_abnormal_nervous_system3.86181030
7MP0003890_abnormal_embryonic-extraembry3.43500416
8MP0003724_increased_susceptibility_to3.35121582
9MP0005499_abnormal_olfactory_system3.31480470
10MP0005394_taste/olfaction_phenotype3.31480470
11MP0005075_abnormal_melanosome_morpholog3.29338817
12MP0002332_abnormal_exercise_endurance3.19635284
13MP0001835_abnormal_antigen_presentation3.08868925
14MP0005058_abnormal_lysosome_morphology3.07762817
15MP0002419_abnormal_innate_immunity2.99386118
16MP0005257_abnormal_intraocular_pressure2.94559881
17MP0003122_maternal_imprinting2.94042740
18MP0009785_altered_susceptibility_to2.88252785
19MP0002148_abnormal_hypersensitivity_rea2.83994725
20MP0003300_gastrointestinal_ulcer2.83083131
21MP0003705_abnormal_hypodermis_morpholog2.82971704
22MP0005025_abnormal_response_to2.62696802
23MP0001790_abnormal_immune_system2.57762437
24MP0005387_immune_system_phenotype2.57762437
25MP0006082_CNS_inflammation2.57061872
26MP0008057_abnormal_DNA_replication2.54526241
27MP0005000_abnormal_immune_tolerance2.54396951
28MP0005671_abnormal_response_to2.51289544
29MP0005397_hematopoietic_system_phenotyp2.48293035
30MP0001545_abnormal_hematopoietic_system2.48293035
31MP0009278_abnormal_bone_marrow2.40411929
32MP0000685_abnormal_immune_system2.39944269
33MP0003656_abnormal_erythrocyte_physiolo2.37354896
34MP0009840_abnormal_foam_cell2.35746343
35MP0003183_abnormal_peptide_metabolism2.31647140
36MP0005464_abnormal_platelet_physiology2.29887285
37MP0001800_abnormal_humoral_immune2.27376442
38MP0002452_abnormal_antigen_presenting2.24152306
39MP0002723_abnormal_immune_serum2.22449099
40MP0006035_abnormal_mitochondrial_morpho2.18357961
41MP0010352_gastrointestinal_tract_polyps2.17311203
42MP0004957_abnormal_blastocyst_morpholog2.13055407
43MP0003121_genomic_imprinting2.09134895
44MP0002420_abnormal_adaptive_immunity2.07359703
45MP0001819_abnormal_immune_cell2.06046706
46MP0002653_abnormal_ependyma_morphology1.99836611
47MP0009764_decreased_sensitivity_to1.96685676
48MP0008961_abnormal_basal_metabolism1.94658361
49MP0002277_abnormal_respiratory_mucosa1.92428367
50MP0000678_abnormal_parathyroid_gland1.88174397
51MP0001533_abnormal_skeleton_physiology1.81998606
52MP0004147_increased_porphyrin_level1.81347742
53MP0003938_abnormal_ear_development1.78968040
54MP0003191_abnormal_cellular_cholesterol1.73487895
55MP0001845_abnormal_inflammatory_respons1.73477817
56MP0005451_abnormal_body_composition1.73122361
57MP0005380_embryogenesis_phenotype1.64368783
58MP0001672_abnormal_embryogenesis/_devel1.64368783
59MP0008469_abnormal_protein_level1.64286500
60MP0003075_altered_response_to1.64066239
61MP0010155_abnormal_intestine_physiology1.62150278
62MP0002398_abnormal_bone_marrow1.61696526
63MP0003806_abnormal_nucleotide_metabolis1.61525092
64MP0002088_abnormal_embryonic_growth/wei1.58058003
65MP0002127_abnormal_cardiovascular_syste1.57279626
66MP0008004_abnormal_stomach_pH1.56715531
67MP0000716_abnormal_immune_system1.56471001
68MP0001849_ear_inflammation1.55841651
69MP0003984_embryonic_growth_retardation1.54994141
70MP0009333_abnormal_splenocyte_physiolog1.52774235
71MP0004510_myositis1.48772357
72MP0000465_gastrointestinal_hemorrhage1.48218025
73MP0002998_abnormal_bone_remodeling1.47593779
74MP0000689_abnormal_spleen_morphology1.47401091
75MP0001293_anophthalmia1.43728115
76MP0005167_abnormal_blood-brain_barrier1.42420146
77MP0002092_abnormal_eye_morphology1.42322123
78MP0002722_abnormal_immune_system1.41107839
79MP0002932_abnormal_joint_morphology1.36930203
80MP0000604_amyloidosis1.36077105
81MP0002429_abnormal_blood_cell1.34872698
82MP0010030_abnormal_orbit_morphology1.31334454
83MP0004947_skin_inflammation1.30227820
84MP0006054_spinal_hemorrhage1.27128597
85MP0000762_abnormal_tongue_morphology1.26901633
86MP0001853_heart_inflammation1.24485123
87MP0005266_abnormal_metabolism1.23589334
88MP0004043_abnormal_pH_regulation1.20251908
89MP0004808_abnormal_hematopoietic_stem1.19359147
90MP0000350_abnormal_cell_proliferation1.18920465
91MP0002086_abnormal_extraembryonic_tissu1.17303789
92MP0003763_abnormal_thymus_physiology1.17119769
93MP0003690_abnormal_glial_cell1.17051785
94MP0000049_abnormal_middle_ear1.16732811
95MP0003123_paternal_imprinting1.10096245
96MP0001348_abnormal_lacrimal_gland1.09536355
97MP0002396_abnormal_hematopoietic_system1.07786281
98MP0002970_abnormal_white_adipose1.07743176
99MP0005248_abnormal_Harderian_gland1.07525500
100MP0005166_decreased_susceptibility_to1.06617578
101MP0009765_abnormal_xenobiotic_induced1.06463665
102MP0008789_abnormal_olfactory_epithelium1.06248090
103MP0008260_abnormal_autophagy1.05203334
104MP0002233_abnormal_nose_morphology1.04963715
105MP0002085_abnormal_embryonic_tissue0.99999839
106MP0004381_abnormal_hair_follicle0.98812502
107MP0002114_abnormal_axial_skeleton0.96842220
108MP0009763_increased_sensitivity_to0.96406291
109MP0000432_abnormal_head_morphology0.95824422
110MP0005164_abnormal_response_to0.94898600
111MP0000703_abnormal_thymus_morphology0.94018210
112MP0000428_abnormal_craniofacial_morphol0.93375200
113MP0003279_aneurysm0.90945256
114MP0008770_decreased_survivor_rate0.89240707
115MP0002837_dystrophic_cardiac_calcinosis0.88985336
116MP0002139_abnormal_hepatobiliary_system0.88965370
117MP0005508_abnormal_skeleton_morphology0.87350788
118MP0003448_altered_tumor_morphology0.85313663
119MP0003935_abnormal_craniofacial_develop0.84883758
120MP0001663_abnormal_digestive_system0.83938821
121MP0003795_abnormal_bone_structure0.83429649
122MP0003077_abnormal_cell_cycle0.83115309
123MP0005391_vision/eye_phenotype0.82969335
124MP0003137_abnormal_impulse_conducting0.82840564
125MP0005023_abnormal_wound_healing0.82251423
126MP0002084_abnormal_developmental_patter0.82131986
127MP0000490_abnormal_crypts_of0.82012186
128MP0003755_abnormal_palate_morphology0.81623187
129MP0003866_abnormal_defecation0.81614450
130MP0002925_abnormal_cardiovascular_devel0.80620042
131MP0003453_abnormal_keratinocyte_physiol0.80199254
132MP0003283_abnormal_digestive_organ0.79238587
133MP0000313_abnormal_cell_death0.79085047
134MP0000343_altered_response_to0.78130837
135MP0002132_abnormal_respiratory_system0.77995281
136MP0003172_abnormal_lysosome_physiology0.77720175
137MP0004197_abnormal_fetal_growth/weight/0.76469653
138MP0003828_pulmonary_edema0.76354898
139MP0000750_abnormal_muscle_regeneration0.76306557
140MP0005390_skeleton_phenotype0.74851790
141MP0003119_abnormal_digestive_system0.73698399
142MP0000015_abnormal_ear_pigmentation0.73055877
143MP0003787_abnormal_imprinting0.72327464
144MP0005083_abnormal_biliary_tract0.71785084
145MP0001873_stomach_inflammation0.71337832
146MP0005197_abnormal_uvea_morphology0.71053855
147MP0000749_muscle_degeneration0.70174304
148MP0004883_abnormal_blood_vessel0.69853951
149MP0004133_heterotaxia0.69459714
150MP0000249_abnormal_blood_vessel0.65902829
151MP0001851_eye_inflammation0.65513082
152MP0002098_abnormal_vibrissa_morphology0.65492146
153MP0005647_abnormal_sex_gland0.64840775
154MP0003646_muscle_fatigue0.64606335
155MP0002138_abnormal_hepatobiliary_system0.63355216
156MP0002269_muscular_atrophy0.63318615
157MP0005319_abnormal_enzyme/_coenzyme0.62652005
158MP0009115_abnormal_fat_cell0.62309759
159MP0002116_abnormal_craniofacial_bone0.61911317
160MP0005310_abnormal_salivary_gland0.60388296
161MP0003436_decreased_susceptibility_to0.60345658
162MP0009703_decreased_birth_body0.60149054
163MP0003315_abnormal_perineum_morphology0.59583760
164MP0000358_abnormal_cell_content/0.58236384
165MP0005174_abnormal_tail_pigmentation0.57331387
166MP0001697_abnormal_embryo_size0.57221672
167MP0001764_abnormal_homeostasis0.57176005
168MP0008874_decreased_physiological_sensi0.57048434
169MP0000609_abnormal_liver_physiology0.56800196
170MP0002751_abnormal_autonomic_nervous0.55658342
171MP0003186_abnormal_redox_activity0.55518833
172MP0002080_prenatal_lethality0.55140942
173MP0005377_hearing/vestibular/ear_phenot0.54764954
174MP0003878_abnormal_ear_physiology0.54764954
175MP0004272_abnormal_basement_membrane0.52208268
176MP0004782_abnormal_surfactant_physiolog0.52092895
177MP0002249_abnormal_larynx_morphology0.52073868
178MP0002693_abnormal_pancreas_physiology0.51648938
179MP0005623_abnormal_meninges_morphology0.50815088
180MP0002405_respiratory_system_inflammati0.50327793
181MP0000858_altered_metastatic_potential0.50290391
182MP0000377_abnormal_hair_follicle0.49969727
183MP0005384_cellular_phenotype0.49011290

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.66543525
2Hypochromic microcytic anemia (HP:0004840)6.45757917
3Hepatoblastoma (HP:0002884)5.59106132
4Multiple enchondromatosis (HP:0005701)5.28214380
5Recurrent abscess formation (HP:0002722)5.25026983
6Abnormality of macrophages (HP:0004311)5.23573740
7Abnormality of the lower motor neuron (HP:0002366)5.03775276
8Recurrent bacterial skin infections (HP:0005406)5.02747850
9Eczematoid dermatitis (HP:0000976)4.84209781
10Rib fusion (HP:0000902)4.75353751
11Increased cerebral lipofuscin (HP:0011813)4.55015075
12Stomatitis (HP:0010280)4.27701135
13Myositis (HP:0100614)4.06656115
14Ependymoma (HP:0002888)4.03565568
15Systemic lupus erythematosus (HP:0002725)4.01786646
16Increased neuronal autofluorescent lipopigment (HP:0002074)3.95246594
17Mediastinal lymphadenopathy (HP:0100721)3.89109989
18Vacuolated lymphocytes (HP:0001922)3.87880215
19Orchitis (HP:0100796)3.85370712
20Recurrent gram-negative bacterial infections (HP:0005420)3.82802017
21Abnormality of the heme biosynthetic pathway (HP:0010472)3.67893071
22Petechiae (HP:0000967)3.67542912
23Neoplasm of striated muscle (HP:0009728)3.63010092
24Testicular atrophy (HP:0000029)3.62756924
25Optic neuritis (HP:0100653)3.62661587
26Retrobulbar optic neuritis (HP:0100654)3.62661587
27Rectal fistula (HP:0100590)3.60442070
28Rectovaginal fistula (HP:0000143)3.60442070
29Spontaneous hematomas (HP:0007420)3.55177697
30Aplasia/Hypoplasia of the fovea (HP:0008060)3.54413512
31Hypoplasia of the fovea (HP:0007750)3.54413512
32Nephroblastoma (Wilms tumor) (HP:0002667)3.53568428
33Partial duplication of thumb phalanx (HP:0009944)3.51071364
34Obstructive lung disease (HP:0006536)3.47306357
35Chronic obstructive pulmonary disease (HP:0006510)3.47306357
36Recurrent fungal infections (HP:0002841)3.42933928
37Fused cervical vertebrae (HP:0002949)3.40045529
38Prolonged bleeding time (HP:0003010)3.36579692
39Rhabdomyosarcoma (HP:0002859)3.33365054
40Loss of speech (HP:0002371)3.31981314
41Dysostosis multiplex (HP:0000943)3.31016616
42Intestinal fistula (HP:0100819)3.28815740
43Embryonal renal neoplasm (HP:0011794)3.27940326
44Chromosomal breakage induced by crosslinking agents (HP:0003221)3.27767897
45Recurrent skin infections (HP:0001581)3.26316840
46Elevated erythrocyte sedimentation rate (HP:0003565)3.20382295
47Autoimmune thrombocytopenia (HP:0001973)3.17832206
48Vaginal fistula (HP:0004320)3.14604750
49Mutism (HP:0002300)3.14295274
50Hematochezia (HP:0002573)3.11912556
51Polycythemia (HP:0001901)3.11877842
52Disinhibition (HP:0000734)3.11176017
53Increased serum ferritin (HP:0003281)3.09677225
54Amyotrophic lateral sclerosis (HP:0007354)3.07695317
55Hyperinsulinemic hypoglycemia (HP:0000825)3.06639177
56Bifid tongue (HP:0010297)3.06067799
57Partial duplication of the phalanx of hand (HP:0009999)3.04749210
58Abnormality of the salivary glands (HP:0010286)3.03997149
59Anomalous pulmonary venous return (HP:0010772)3.03992338
60Ragged-red muscle fibers (HP:0003200)3.00568456
61Horizontal nystagmus (HP:0000666)2.98579474
62Abnormality of iron homeostasis (HP:0011031)2.98474053
63Abnormality of glycolipid metabolism (HP:0010969)2.95168000
64Abnormality of liposaccharide metabolism (HP:0010968)2.95168000
65Abnormality of glycosphingolipid metabolism (HP:0004343)2.95168000
66Recurrent cutaneous fungal infections (HP:0011370)2.91364618
67Chronic mucocutaneous candidiasis (HP:0002728)2.91364618
68Abnormality of the astrocytes (HP:0100707)2.88650538
69Astrocytoma (HP:0009592)2.88650538
70Abnormal cartilage morphology (HP:0002763)2.88563259
71Short humerus (HP:0005792)2.86917038
72Aplasia/hypoplasia of the humerus (HP:0006507)2.84882371
73Meningitis (HP:0001287)2.81500944
74Recurrent viral infections (HP:0004429)2.79425743
75Glomerulonephritis (HP:0000099)2.76625500
76Hypochromic anemia (HP:0001931)2.76410839
77Gingivitis (HP:0000230)2.73938972
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.72870332
79Abnormality of the fovea (HP:0000493)2.72282159
80Trismus (HP:0000211)2.71388729
81Chromsome breakage (HP:0040012)2.70680721
82Abnormality of the vasculature of the conjunctiva (HP:0008054)2.68576094
83Preauricular pit (HP:0004467)2.67351360
84Periauricular skin pits (HP:0100277)2.67351360
85Epistaxis (HP:0000421)2.65480431
86Keratoconjunctivitis sicca (HP:0001097)2.64783272
87Abnormality of transition element cation homeostasis (HP:0011030)2.63075405
88Large earlobe (HP:0009748)2.62865589
89Reduced antithrombin III activity (HP:0001976)2.62562529
90Urticaria (HP:0001025)2.62302746
91Abnormal lung lobation (HP:0002101)2.60310701
92Abnormality of the pulmonary veins (HP:0011718)2.58709388
93Preauricular skin tag (HP:0000384)2.57589662
94Purpura (HP:0000979)2.57095097
95Encephalitis (HP:0002383)2.55605529
96Upper motor neuron abnormality (HP:0002127)2.55386506
97Generalized hypotonia (HP:0001290)2.54970942
98Vasculitis (HP:0002633)2.54513106
99Hemoptysis (HP:0002105)2.54295029
100Keratoconjunctivitis (HP:0001096)2.53919830
101Abnormality of polysaccharide metabolism (HP:0011012)2.50168637
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.50168637
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.50168637
104Sensory axonal neuropathy (HP:0003390)2.50032844
105Increased connective tissue (HP:0009025)2.49858226
106Microcytic anemia (HP:0001935)2.49742488
107Hyperventilation (HP:0002883)2.47932319
108Thoracic kyphosis (HP:0002942)2.46588208
109Pulmonary infiltrates (HP:0002113)2.43767447
110Abnormality of the phalanges of the hallux (HP:0010057)2.43475396
111Cellulitis (HP:0100658)2.43129376
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.42962909
113Difficulty running (HP:0009046)2.39885922
114Pustule (HP:0200039)2.39609981
115Inflammation of the large intestine (HP:0002037)2.38858536
116Aplasia/Hypoplasia of the macula (HP:0008059)2.37854944
117Tetraplegia (HP:0002445)2.33914249
118Abnormality of the distal phalanx of the thumb (HP:0009617)2.33211155
119Increased IgE level (HP:0003212)2.29105242
120Shawl scrotum (HP:0000049)2.28409871
121Gastrointestinal inflammation (HP:0004386)2.28301172
122Colitis (HP:0002583)2.27762873
123Skin tags (HP:0010609)2.27723830
124Nasolacrimal duct obstruction (HP:0000579)2.27384810
125Hand muscle atrophy (HP:0009130)2.27203170
126Neoplasm of the heart (HP:0100544)2.26452692
127Cheilitis (HP:0100825)2.26061458
128Pendular nystagmus (HP:0012043)2.24753029
129Abnormality of small intestinal villus morphology (HP:0011472)2.24242625
130Villous atrophy (HP:0011473)2.24242625
131Leukocytosis (HP:0001974)2.23608435
132Hypopigmentation of the fundus (HP:0007894)2.23267621
133Nasal polyposis (HP:0100582)2.22540804
134Urinary glycosaminoglycan excretion (HP:0003541)2.22355928
135Mucopolysacchariduria (HP:0008155)2.22355928
136Abnormality of the musculature of the hand (HP:0001421)2.22212784
137Osteomyelitis (HP:0002754)2.21796146
138Hepatosplenomegaly (HP:0001433)2.19070348
139Gastrointestinal infarctions (HP:0005244)2.19012534
140Short 5th finger (HP:0009237)2.18790358
141Abnormality of chromosome segregation (HP:0002916)2.18173404
142Progressive muscle weakness (HP:0003323)2.18075661
143Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.17511313
144Abnormality of the pubic bones (HP:0003172)2.16534799
145Aplasia/Hypoplasia affecting the retina (HP:0008061)2.13955997
146Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.13230392
147Tongue fasciculations (HP:0001308)2.13098474
148Impulsivity (HP:0100710)2.12389803
149Esophageal neoplasm (HP:0100751)2.10247019
150Neoplasm of head and neck (HP:0012288)2.10247019
151Polyneuropathy (HP:0001271)2.07815741
152Skin pits (HP:0100276)2.05684940
153Panhypogammaglobulinemia (HP:0003139)2.04946244
154Reticulocytosis (HP:0001923)2.04873493
155Skin nodule (HP:0200036)2.04379029
156Glioma (HP:0009733)2.04342486
157Meckel diverticulum (HP:0002245)2.04100230
158Pseudobulbar signs (HP:0002200)2.03846693
159Peritonitis (HP:0002586)2.03062661
160Amyloidosis (HP:0011034)2.02512465
161Renal duplication (HP:0000075)2.02012117
162Spastic tetraparesis (HP:0001285)2.01976257
163Episodic fever (HP:0001954)2.01204049
164Gastrointestinal stroma tumor (HP:0100723)2.00792041
165Abnormality of the intrinsic pathway (HP:0010989)2.00207880
166Anorexia (HP:0002039)1.99708688
167Paralysis (HP:0003470)1.99693997
168Achilles tendon contracture (HP:0001771)1.99622613
169Abnormal platelet function (HP:0011869)1.99425167
170Impaired platelet aggregation (HP:0003540)1.99425167
171Supernumerary nipples (HP:0002558)1.98836754
172Myocardial infarction (HP:0001658)1.98663654
173Conjunctival telangiectasia (HP:0000524)1.98516736
174Gingival bleeding (HP:0000225)1.97844039
175Combined immunodeficiency (HP:0005387)1.96953132
176Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96755614
177Malignant neoplasm of the central nervous system (HP:0100836)1.96404923
178Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.96197289
179Arterial thrombosis (HP:0004420)1.95703599
180Fasciculations (HP:0002380)1.95333444
181Albinism (HP:0001022)1.94936434
182Muscle fibrillation (HP:0010546)1.93606525
183Upper limb muscle weakness (HP:0003484)1.93103267
184Aplasia/Hypoplasia of the uvula (HP:0010293)1.92710994
185Abnormality of the periventricular white matter (HP:0002518)1.92528220
186Vertigo (HP:0002321)1.92103503
187Abnormal hemoglobin (HP:0011902)1.91899916
188Hypoplastic scapulae (HP:0000882)1.91686975
189Aplasia/Hypoplasia of the scapulae (HP:0006713)1.91686975
190T lymphocytopenia (HP:0005403)1.91599594
191Vertebral fusion (HP:0002948)1.91235438
192Progressive neurologic deterioration (HP:0002344)1.90242586
193Restrictive lung disease (HP:0002091)1.89956083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.29111768
2GRK55.58863109
3ERN14.95327802
4GRK64.41789977
5ADRBK23.37410437
6TGFBR23.32126346
7GRK13.28515173
8CSF1R3.26397738
9MAP4K13.10770582
10GRK72.81310092
11MAP2K32.56890068
12TYRO32.55920530
13TYK22.54341845
14MATK2.47090966
15JAK32.43581222
16MAP3K132.34938503
17MAPK72.33310052
18ZAP702.29213838
19STK102.26361846
20MOS2.21108874
21IRAK42.20938657
22TTK2.19874194
23MAP3K142.18354498
24FES2.12752820
25NME22.05535393
26WNK11.98507499
27IRAK31.96204086
28SYK1.82564478
29TBK11.78906733
30BTK1.70960528
31TAOK21.67972831
32TNK21.66711228
33TXK1.65874299
34MAP3K111.64720178
35NTRK11.61982581
36TAOK11.60896977
37CAMK41.49518784
38PRKG21.46484494
39MARK31.45873607
40MAP3K31.45835899
41LYN1.44332887
42IKBKE1.44212696
43TEC1.33279908
44MAP3K11.30009990
45PAK41.28696901
46CDK71.26516401
47MARK21.23979264
48FGFR31.16201649
49MAP2K41.14295826
50MAP3K101.12073446
51ADRBK11.10705470
52LCK1.09475961
53HIPK21.09390269
54CDC42BPA1.06964156
55CSK1.02181302
56TIE11.02113552
57EPHA21.00676502
58CHEK20.94165533
59AKT30.90711951
60DAPK20.81181082
61TAOK30.78362074
62JAK10.77286477
63PASK0.74656172
64PLK10.73443400
65KSR20.71868015
66CLK10.71579185
67MAP2K60.70267997
68MAPK120.69702193
69BLK0.68936367
70RPS6KL10.68738141
71RPS6KC10.68738141
72MAP3K70.67906304
73BMPR20.67110094
74ALK0.66004624
75AKT20.65008214
76TGFBR10.63712661
77PDPK10.62027803
78EIF2AK20.61109171
79PRKCQ0.60903024
80RPS6KA60.60007208
81CAMKK20.58313352
82PTK60.56576652
83PIM10.55054670
84BMX0.54382553
85RIPK10.53947501
86ACVR1B0.53200840
87CHEK10.52631904
88MAP3K90.50522093
89CAMKK10.50423707
90MAP3K50.49803779
91IGF1R0.49495451
92IKBKB0.47908528
93IRAK20.46866847
94MTOR0.46797815
95MAP3K80.46476019
96IRAK10.46280083
97PDK20.45557421
98LATS20.45024689
99PINK10.43471023
100PIK3CG0.42361223
101TRPM70.41719865
102PTK2B0.41247540
103MAP3K60.39890961
104PTK20.39884396
105PRKCD0.39780346
106ABL20.39651306
107ITK0.39530840
108STK110.36364395
109PDGFRA0.35220231
110ERBB20.34369981
111TAF10.33403127
112RPS6KA20.31081110
113MAP3K20.30290245
114CDK20.29830789
115CDK60.29347378
116INSR0.29249082
117TRIB30.28731012
118PIM20.27769722
119GSK3A0.25691493
120SIK10.25589053
121MAPK100.24562290
122PRKCI0.23182876
123CDK40.22978169
124STK380.22957380
125DDR20.21900310
126SIK20.21863232
127KIT0.20831267
128PAK10.20534624
129CHUK0.20012889
130PRKACG0.19684773
131MAPK40.19619466
132NEK20.18339418
133ATM0.18041265
134MAPK10.18000685
135ICK0.17962330
136HCK0.16201715
137CSNK1E0.15758024
138PRPF4B0.15671651
139PRKD20.15274301
140AURKA0.13465486
141EGFR0.13381962
142PRKAA10.12952238
143GSK3B0.12900863
144JAK20.12635765
145MAPK140.12532707
146PRKACB0.12271770
147CAMK1D0.11966489
148RIPK40.11871223
149CDK10.11357460
150FGR0.11352733
151DYRK1B0.09906696
152MAPKAPK20.09605813
153MET0.09118226
154CDK150.09097881
155DYRK1A0.09030073
156RPS6KB20.08047328
157RPS6KA30.07765034
158ABL10.07547618
159PDK10.07218989
160SRC0.07026722
161PRKACA0.06933237
162PAK30.06228623
163CDK11A0.06188361
164CDC70.05405591

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.86612860
2Fructose and mannose metabolism_Homo sapiens_hsa000514.18577392
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33222327
4Arachidonic acid metabolism_Homo sapiens_hsa005903.09282911
5Osteoclast differentiation_Homo sapiens_hsa043802.98016031
6* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.96476106
7Galactose metabolism_Homo sapiens_hsa000522.94528690
8Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.49627086
9Linoleic acid metabolism_Homo sapiens_hsa005912.45138762
10Allograft rejection_Homo sapiens_hsa053302.31029855
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.29675154
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.29547122
13Rheumatoid arthritis_Homo sapiens_hsa053232.29237727
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.26981924
15Asthma_Homo sapiens_hsa053102.26094765
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.12341623
17Graft-versus-host disease_Homo sapiens_hsa053322.11825707
18Other glycan degradation_Homo sapiens_hsa005112.10875093
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09781204
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03843159
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02627538
22Autoimmune thyroid disease_Homo sapiens_hsa053201.96642674
23Hematopoietic cell lineage_Homo sapiens_hsa046401.92105167
24mTOR signaling pathway_Homo sapiens_hsa041501.81166421
25Pertussis_Homo sapiens_hsa051331.73811778
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66226626
27Phagosome_Homo sapiens_hsa041451.62807964
28TNF signaling pathway_Homo sapiens_hsa046681.60476236
29Type I diabetes mellitus_Homo sapiens_hsa049401.59379329
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.59140387
31Antigen processing and presentation_Homo sapiens_hsa046121.55058195
32Thyroid cancer_Homo sapiens_hsa052161.48980011
33Primary immunodeficiency_Homo sapiens_hsa053401.48380177
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37333485
35Chemokine signaling pathway_Homo sapiens_hsa040621.35731096
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32063779
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28624264
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.24427696
39Measles_Homo sapiens_hsa051621.21680882
40African trypanosomiasis_Homo sapiens_hsa051431.21625642
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21528978
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18757812
43Ether lipid metabolism_Homo sapiens_hsa005651.16919924
44Collecting duct acid secretion_Homo sapiens_hsa049661.15159332
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12788712
46Complement and coagulation cascades_Homo sapiens_hsa046101.12240963
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10548649
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.10000008
49Salmonella infection_Homo sapiens_hsa051321.07207446
50Ovarian steroidogenesis_Homo sapiens_hsa049131.05291520
51Inositol phosphate metabolism_Homo sapiens_hsa005621.04135517
52Hepatitis B_Homo sapiens_hsa051611.03636686
53Chemical carcinogenesis_Homo sapiens_hsa052041.01741916
54Platelet activation_Homo sapiens_hsa046110.97400513
55Viral myocarditis_Homo sapiens_hsa054160.95797758
56Staphylococcus aureus infection_Homo sapiens_hsa051500.93630160
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91600545
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91123497
59Leishmaniasis_Homo sapiens_hsa051400.89611720
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89255029
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87980997
62Acute myeloid leukemia_Homo sapiens_hsa052210.86926606
63Choline metabolism in cancer_Homo sapiens_hsa052310.84420062
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.84406732
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84325127
66RNA transport_Homo sapiens_hsa030130.81714103
67Pathways in cancer_Homo sapiens_hsa052000.79960493
68Rap1 signaling pathway_Homo sapiens_hsa040150.77367211
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75724749
70mRNA surveillance pathway_Homo sapiens_hsa030150.75254247
71MicroRNAs in cancer_Homo sapiens_hsa052060.72792009
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71445621
73Chronic myeloid leukemia_Homo sapiens_hsa052200.71441518
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.70907613
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70867614
76Herpes simplex infection_Homo sapiens_hsa051680.70811492
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.70603331
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70347568
79Shigellosis_Homo sapiens_hsa051310.70171611
80Fanconi anemia pathway_Homo sapiens_hsa034600.69413364
81Apoptosis_Homo sapiens_hsa042100.68464007
82Prolactin signaling pathway_Homo sapiens_hsa049170.67090074
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.64447333
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64003740
85One carbon pool by folate_Homo sapiens_hsa006700.63559994
86Amoebiasis_Homo sapiens_hsa051460.62351489
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61403398
88Non-small cell lung cancer_Homo sapiens_hsa052230.60094823
89Tryptophan metabolism_Homo sapiens_hsa003800.58998623
90Notch signaling pathway_Homo sapiens_hsa043300.58968992
91VEGF signaling pathway_Homo sapiens_hsa043700.56679446
92Malaria_Homo sapiens_hsa051440.55128847
93Legionellosis_Homo sapiens_hsa051340.53809890
94Proteoglycans in cancer_Homo sapiens_hsa052050.53324929
95Basal cell carcinoma_Homo sapiens_hsa052170.53067753
96Pentose phosphate pathway_Homo sapiens_hsa000300.52972356
97B cell receptor signaling pathway_Homo sapiens_hsa046620.52950873
98Type II diabetes mellitus_Homo sapiens_hsa049300.52130595
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52109002
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.51756021
101Pancreatic cancer_Homo sapiens_hsa052120.51169201
102Epstein-Barr virus infection_Homo sapiens_hsa051690.50019240
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48274649
104Sphingolipid metabolism_Homo sapiens_hsa006000.47988408
105HIF-1 signaling pathway_Homo sapiens_hsa040660.46650098
106Lysosome_Homo sapiens_hsa041420.45941687
107Influenza A_Homo sapiens_hsa051640.45836914
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45742104
109Tuberculosis_Homo sapiens_hsa051520.45675486
110Mineral absorption_Homo sapiens_hsa049780.43960426
111HTLV-I infection_Homo sapiens_hsa051660.43755315
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.43555540
113Hedgehog signaling pathway_Homo sapiens_hsa043400.43235918
114Bladder cancer_Homo sapiens_hsa052190.40941013
115AMPK signaling pathway_Homo sapiens_hsa041520.40585295
116Viral carcinogenesis_Homo sapiens_hsa052030.40514428
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39049343
118Systemic lupus erythematosus_Homo sapiens_hsa053220.37399700
119Folate biosynthesis_Homo sapiens_hsa007900.37084738
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36882827
121Sulfur relay system_Homo sapiens_hsa041220.36547855
122Cell cycle_Homo sapiens_hsa041100.36470608
123p53 signaling pathway_Homo sapiens_hsa041150.36011136
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35696808
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35280456
126Ras signaling pathway_Homo sapiens_hsa040140.34541665
127RNA degradation_Homo sapiens_hsa030180.34400282
128Adherens junction_Homo sapiens_hsa045200.34258177
129Renin-angiotensin system_Homo sapiens_hsa046140.34176884
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.34068214
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32935502
132ABC transporters_Homo sapiens_hsa020100.32609438
133Protein digestion and absorption_Homo sapiens_hsa049740.32316679
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30554094
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28808987
136Hippo signaling pathway_Homo sapiens_hsa043900.27871493
137Endocytosis_Homo sapiens_hsa041440.27475153
138Prion diseases_Homo sapiens_hsa050200.26710098
139MAPK signaling pathway_Homo sapiens_hsa040100.26649062
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.26570372
141Toxoplasmosis_Homo sapiens_hsa051450.25917389
142Toll-like receptor signaling pathway_Homo sapiens_hsa046200.24864607
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24847025
144GnRH signaling pathway_Homo sapiens_hsa049120.24616410
145Dorso-ventral axis formation_Homo sapiens_hsa043200.24000211
146Insulin resistance_Homo sapiens_hsa049310.22924996
147T cell receptor signaling pathway_Homo sapiens_hsa046600.22678589
148Hepatitis C_Homo sapiens_hsa051600.22428802
149Estrogen signaling pathway_Homo sapiens_hsa049150.21601931
150Taste transduction_Homo sapiens_hsa047420.21123067
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.21120219
152Renal cell carcinoma_Homo sapiens_hsa052110.20348698

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