GATSL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)5.12118667
2ribosome assembly (GO:0042255)5.10031340
3purine nucleobase biosynthetic process (GO:0009113)4.95761698
4purine deoxyribonucleotide catabolic process (GO:0009155)4.81936317
5nucleobase biosynthetic process (GO:0046112)4.79875343
6mitotic metaphase plate congression (GO:0007080)4.61417544
7fatty acid elongation (GO:0030497)4.59338739
8ribosome biogenesis (GO:0042254)4.44916823
9purine nucleotide salvage (GO:0032261)4.42734278
10maturation of SSU-rRNA (GO:0030490)4.36468736
11regulation of cholesterol esterification (GO:0010872)4.28414937
12DNA replication checkpoint (GO:0000076)4.12810184
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.09001991
14rRNA modification (GO:0000154)4.00819690
15ribonucleoprotein complex biogenesis (GO:0022613)3.94779112
16regulation of spindle organization (GO:0090224)3.87373796
17heart process (GO:0003015)3.86527307
18heart contraction (GO:0060047)3.86527307
19folic acid metabolic process (GO:0046655)3.81556158
20regulation of gene silencing by RNA (GO:0060966)3.76073405
21regulation of posttranscriptional gene silencing (GO:0060147)3.76073405
22regulation of gene silencing by miRNA (GO:0060964)3.76073405
23mitotic nuclear envelope disassembly (GO:0007077)3.74058334
24nucleotide salvage (GO:0043173)3.72436981
25phospholipid efflux (GO:0033700)3.69610549
26DNA replication initiation (GO:0006270)3.69389115
27metallo-sulfur cluster assembly (GO:0031163)3.68877841
28iron-sulfur cluster assembly (GO:0016226)3.68877841
29purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.67264621
30metaphase plate congression (GO:0051310)3.64711505
31purine deoxyribonucleotide metabolic process (GO:0009151)3.61634752
32ribosomal large subunit biogenesis (GO:0042273)3.61365922
33protein localization to kinetochore (GO:0034501)3.59649200
34DNA deamination (GO:0045006)3.59064599
35protein K6-linked ubiquitination (GO:0085020)3.57638895
36rRNA processing (GO:0006364)3.57013741
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.54728673
38regulation of cytokine secretion involved in immune response (GO:0002739)3.53000710
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50867644
40negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.48437847
41proteasome assembly (GO:0043248)3.45901114
42membrane disassembly (GO:0030397)3.44767405
43nuclear envelope disassembly (GO:0051081)3.44767405
44extracellular fibril organization (GO:0043206)3.44765702
45rRNA metabolic process (GO:0016072)3.44047546
46peptidyl-histidine modification (GO:0018202)3.44020872
47ribosomal small subunit biogenesis (GO:0042274)3.41186324
48translational initiation (GO:0006413)3.40734303
49regulation of mitotic spindle organization (GO:0060236)3.39177656
50DNA strand elongation involved in DNA replication (GO:0006271)3.38543862
51IMP biosynthetic process (GO:0006188)3.35927318
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35145743
53deoxyribose phosphate catabolic process (GO:0046386)3.29564047
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.27380245
55spliceosomal snRNP assembly (GO:0000387)3.27218696
56termination of RNA polymerase I transcription (GO:0006363)3.27183525
57positive regulation of chromosome segregation (GO:0051984)3.26860460
58viral transcription (GO:0019083)3.25533482
59folic acid-containing compound biosynthetic process (GO:0009396)3.25533264
60maturation of 5.8S rRNA (GO:0000460)3.25155341
61nuclear pore organization (GO:0006999)3.24962520
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24382182
63protein deneddylation (GO:0000338)3.24208129
64translational termination (GO:0006415)3.23030160
65cullin deneddylation (GO:0010388)3.22540215
66pseudouridine synthesis (GO:0001522)3.22435037
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21876561
68DNA replication-dependent nucleosome organization (GO:0034723)3.20249795
69DNA replication-dependent nucleosome assembly (GO:0006335)3.20249795
70DNA strand elongation (GO:0022616)3.18599547
71transcription from RNA polymerase I promoter (GO:0006360)3.18370270
72deoxyribonucleotide catabolic process (GO:0009264)3.17657180
73regulation of translation in response to stress (GO:0043555)3.15552080
74neutrophil activation involved in immune response (GO:0002283)3.14778446
75regulation of nuclear cell cycle DNA replication (GO:0033262)3.13842080
76mannose metabolic process (GO:0006013)3.13456387
77regulation of B cell receptor signaling pathway (GO:0050855)3.12883011
78branched-chain amino acid catabolic process (GO:0009083)3.11734194
79positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.11105975
80rRNA methylation (GO:0031167)3.09743974
81fibril organization (GO:0097435)3.08703286
82mature B cell differentiation involved in immune response (GO:0002313)3.08308361
83translational elongation (GO:0006414)3.05705193
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04526638
85deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04364403
86termination of RNA polymerase III transcription (GO:0006386)3.02734222
87transcription elongation from RNA polymerase III promoter (GO:0006385)3.02734222
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.02335895
89telomere maintenance via semi-conservative replication (GO:0032201)3.02101433
90establishment of chromosome localization (GO:0051303)3.00926594
91negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.97963327
92membrane raft organization (GO:0031579)2.97474038
93protein localization to chromosome, centromeric region (GO:0071459)2.97438207
94transcription elongation from RNA polymerase I promoter (GO:0006362)2.96805581
95ribosomal small subunit assembly (GO:0000028)2.96236854
96transcription from mitochondrial promoter (GO:0006390)2.96119671
97attachment of spindle microtubules to kinetochore (GO:0008608)2.95404952
98negative regulation of ligase activity (GO:0051352)2.94134742
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94134742
100blastocyst development (GO:0001824)2.93769174
101folic acid transport (GO:0015884)2.90373182
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.89329365
103transcription-coupled nucleotide-excision repair (GO:0006283)2.88917801
104acyl-CoA biosynthetic process (GO:0071616)2.87794858
105thioester biosynthetic process (GO:0035384)2.87794858
106negative regulation of nitric-oxide synthase activity (GO:0051001)2.87711757
107regulation of double-strand break repair via homologous recombination (GO:0010569)2.87033396
108amyloid precursor protein catabolic process (GO:0042987)2.85461675
109negative regulation of chromosome segregation (GO:0051985)2.84615745
110G1/S transition of mitotic cell cycle (GO:0000082)2.83958207
111cell cycle G1/S phase transition (GO:0044843)2.83958207
112transcription initiation from RNA polymerase I promoter (GO:0006361)2.83376520
113regulation of helicase activity (GO:0051095)2.82662963
114positive regulation of ligase activity (GO:0051351)2.82621042
115mannosylation (GO:0097502)2.82495519
1167-methylguanosine mRNA capping (GO:0006370)2.79820150
117aggressive behavior (GO:0002118)2.78278814
118IMP metabolic process (GO:0046040)2.77960192
119nuclear envelope organization (GO:0006998)2.77495402
120regulation of centrosome cycle (GO:0046605)2.76679732
121mitotic sister chromatid segregation (GO:0000070)2.75975784
122establishment of protein localization to mitochondrial membrane (GO:0090151)2.75893717
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75699817
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.74698514
125signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74698514
126regulation of ubiquitin-protein transferase activity (GO:0051438)2.74509915
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73968095
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73968095
129signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73968095
130protein kinase C signaling (GO:0070528)2.73386974
131positive regulation of SMAD protein import into nucleus (GO:0060391)2.73186333
132purine-containing compound salvage (GO:0043101)2.73178226
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.73092344
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.73092344
135telomere maintenance via telomere lengthening (GO:0010833)2.72969205
136spindle checkpoint (GO:0031577)2.72458651
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.72256919
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.72256919
139negative regulation of sister chromatid segregation (GO:0033046)2.72256919
140negative regulation of mitotic sister chromatid separation (GO:2000816)2.72256919
141T cell migration (GO:0072678)2.70923508
142alpha-linolenic acid metabolic process (GO:0036109)2.68184854
143aerobic respiration (GO:0009060)2.68027634
144galactose catabolic process (GO:0019388)2.66481042
145plasma lipoprotein particle clearance (GO:0034381)2.66076097
146glutathione derivative metabolic process (GO:1901685)2.64619030
147glutathione derivative biosynthetic process (GO:1901687)2.64619030
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62812737
149negative regulation of nitric oxide biosynthetic process (GO:0045019)2.62321179
150nucleoside salvage (GO:0043174)2.62218587
151cell wall macromolecule catabolic process (GO:0016998)2.59950865
152hemoglobin metabolic process (GO:0020027)2.57292916
153lipopolysaccharide metabolic process (GO:0008653)2.56383468
154positive regulation of natural killer cell differentiation (GO:0032825)2.55478946
155cholesterol catabolic process (GO:0006707)2.53741794
156sterol catabolic process (GO:0016127)2.53741794
157pinocytosis (GO:0006907)2.53002562
158positive regulation of triglyceride lipase activity (GO:0061365)2.52754523
159positive regulation of lipoprotein lipase activity (GO:0051006)2.52754523
160hydrogen peroxide catabolic process (GO:0042744)2.50951824
161positive regulation of calcium-mediated signaling (GO:0050850)2.50754909
162negative regulation of smooth muscle cell migration (GO:0014912)2.50503860
163branched-chain amino acid metabolic process (GO:0009081)2.50267042
164response to interferon-beta (GO:0035456)2.49175250
165positive regulation of cholesterol efflux (GO:0010875)2.48023121
166regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47513754
167response to gravity (GO:0009629)2.46988998
168valine metabolic process (GO:0006573)2.45989096
169lipopolysaccharide biosynthetic process (GO:0009103)2.45439302
170negative T cell selection (GO:0043383)2.44212881
171estrogen biosynthetic process (GO:0006703)2.43845602
172deoxyribose phosphate metabolic process (GO:0019692)2.43333886
173positive regulation of actin cytoskeleton reorganization (GO:2000251)2.41752908
174GMP metabolic process (GO:0046037)2.40157119
175tricarboxylic acid cycle (GO:0006099)2.39785417
176negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.39002341
177regulation of T cell receptor signaling pathway (GO:0050856)2.38054582
178deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.34180574
179tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33685933
180RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33685933
181nonribosomal peptide biosynthetic process (GO:0019184)2.33474263
182vagina development (GO:0060068)2.33062813
183regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.32715173
184glyoxylate metabolic process (GO:0046487)2.32493709
185positive regulation of fatty acid biosynthetic process (GO:0045723)2.32429154
186cellular metabolic compound salvage (GO:0043094)2.32308318
187positive thymic T cell selection (GO:0045059)2.31677641
188high-density lipoprotein particle remodeling (GO:0034375)2.31613175
189positive regulation of interleukin-17 production (GO:0032740)2.31453073
190negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.31416562
191regulation of mast cell degranulation (GO:0043304)2.31127098
192glutathione biosynthetic process (GO:0006750)2.31119769
193COPI coating of Golgi vesicle (GO:0048205)2.30954699
194Golgi transport vesicle coating (GO:0048200)2.30954699
195positive regulation of sterol transport (GO:0032373)2.30813321
196positive regulation of cholesterol transport (GO:0032376)2.30813321
197negative regulation of myeloid cell apoptotic process (GO:0033033)2.30014552
198hyperosmotic salinity response (GO:0042538)2.29484387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.88531804
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.12083739
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.27137959
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25027187
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.89374029
6MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71825450
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69387954
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.68180183
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68075711
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57609215
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.53658065
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.53658065
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.53658065
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.53370774
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.52758592
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.52615366
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.47641586
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.45301657
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39701459
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38970138
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.28880027
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25795801
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20159319
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18051706
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13315099
26IRF8_22096565_ChIP-ChIP_GC-B_Human2.11969780
27XRN2_22483619_ChIP-Seq_HELA_Human2.11341767
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.10887238
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10265432
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05796299
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02924513
32STAT3_1855785_ChIP-Seq_MESCs_Mouse2.00288268
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99142846
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98694070
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94293763
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93513380
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92164095
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89466089
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88894727
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88288430
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.87112237
42AR_21909140_ChIP-Seq_LNCAP_Human1.86951209
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.86367053
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86205389
45VDR_23849224_ChIP-Seq_CD4+_Human1.84929955
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.79590175
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79236003
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.76870561
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76343515
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74067977
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.73699776
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73572454
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.71714067
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71107017
55DCP1A_22483619_ChIP-Seq_HELA_Human1.66616947
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66584325
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.66457066
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65842895
59GABP_19822575_ChIP-Seq_HepG2_Human1.65312590
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63769440
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.61895150
62* UTX_26944678_Chip-Seq_JUKART_Human1.58064250
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53244753
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52196218
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50842262
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.50549692
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.49998447
68TTF2_22483619_ChIP-Seq_HELA_Human1.48025672
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.46884810
70FOXP3_21729870_ChIP-Seq_TREG_Human1.45571152
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42455521
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.42158282
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42129154
74BCL6_27268052_Chip-Seq_Bcells_Human1.41371066
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41343661
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40587439
77SPI1_23547873_ChIP-Seq_NB4_Human1.39681625
78MYC_22102868_ChIP-Seq_BL_Human1.39222801
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39034682
80IRF8_21731497_ChIP-ChIP_J774_Mouse1.36317220
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.35609771
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.34065764
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.33791862
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31131692
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31075203
86KDM5A_27292631_Chip-Seq_BREAST_Human1.29803763
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29722786
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29404126
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.29204298
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.28979107
91SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.28924518
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27707862
93* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27459892
94TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27327200
95RUNX_20019798_ChIP-Seq_JUKART_Human1.26633052
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26511053
97MAF_26560356_Chip-Seq_TH1_Human1.26438067
98ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.25469654
99ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25041946
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24911899
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23228989
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23030805
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22841927
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22494241
105MAF_26560356_Chip-Seq_TH2_Human1.22290282
106VDR_21846776_ChIP-Seq_THP-1_Human1.22220412
107CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22097239
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21107407
109SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20594241
110BCOR_27268052_Chip-Seq_Bcells_Human1.20529800
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.19807562
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19669711
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.19646894
114LXR_22292898_ChIP-Seq_THP-1_Human1.19489732
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19008058
116NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18866617
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18485250
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.18234625
119MYB_26560356_Chip-Seq_TH2_Human1.17472246
120MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17154142
121VDR_24763502_ChIP-Seq_THP-1_Human1.16982598
122ZNF263_19887448_ChIP-Seq_K562_Human1.15168828
123CIITA_25753668_ChIP-Seq_RAJI_Human1.13413794
124E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13057640
125NANOG_21062744_ChIP-ChIP_HESCs_Human1.12682532
126TP63_19390658_ChIP-ChIP_HaCaT_Human1.12260423
127* CTCF_26484167_Chip-Seq_Bcells_Mouse1.12074761
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11875424
129SRF_21415370_ChIP-Seq_HL-1_Mouse1.11519071
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10819810
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10759625
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09985358
133YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09439753
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08681647
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08178937
136PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08101158
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07866134
138RUNX1_22412390_ChIP-Seq_EML_Mouse1.07474170
139ELK1_22589737_ChIP-Seq_MCF10A_Human1.07077285
140ELK1_19687146_ChIP-ChIP_HELA_Human1.05942002
141HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05695434
142GATA2_21666600_ChIP-Seq_HMVEC_Human1.05460366
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05194945
144NOTCH1_21737748_ChIP-Seq_TLL_Human1.04592650
145ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04453267
146POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04102128
147TFEB_21752829_ChIP-Seq_HELA_Human1.03763702
148PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03435998
149DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03141663
150* RACK7_27058665_Chip-Seq_MCF-7_Human1.02942714
151RXR_22158963_ChIP-Seq_LIVER_Mouse1.02166391
152ESR2_21235772_ChIP-Seq_MCF-7_Human1.01566010
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01020172
154BP1_19119308_ChIP-ChIP_Hs578T_Human1.00724968
155* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99842184
156SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99535669
157SALL1_21062744_ChIP-ChIP_HESCs_Human0.99535291
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99457661
159EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99197377
160SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98261221
161FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98159826
162P68_20966046_ChIP-Seq_HELA_Human0.97992071
163NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96358151
164POU5F1_16518401_ChIP-PET_MESCs_Mouse0.96113669
165SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94699296
166* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92682429
167HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91392419
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91280879
169BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91151172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.83933825
2MP0003191_abnormal_cellular_cholesterol4.58791460
3MP0004957_abnormal_blastocyst_morpholog4.22326261
4MP0003111_abnormal_nucleus_morphology3.93840028
5MP0010094_abnormal_chromosome_stability3.53309162
6MP0003077_abnormal_cell_cycle3.30690178
7MP0008057_abnormal_DNA_replication2.89749420
8MP0003436_decreased_susceptibility_to2.79739478
9MP0005058_abnormal_lysosome_morphology2.48789954
10MP0002736_abnormal_nociception_after2.41420318
11MP0010352_gastrointestinal_tract_polyps2.38350005
12MP0003718_maternal_effect2.36655508
13MP0008007_abnormal_cellular_replicative2.33822109
14MP0008058_abnormal_DNA_repair2.29583220
15MP0001730_embryonic_growth_arrest2.29258409
16MP0005670_abnormal_white_adipose2.19308466
17MP0008932_abnormal_embryonic_tissue2.18502666
18MP0003786_premature_aging2.11052218
19MP0003705_abnormal_hypodermis_morpholog2.08310681
20MP0000350_abnormal_cell_proliferation2.05347638
21MP0001986_abnormal_taste_sensitivity1.96922861
22MP0002148_abnormal_hypersensitivity_rea1.86248881
23MP0001672_abnormal_embryogenesis/_devel1.86182227
24MP0005380_embryogenesis_phenotype1.86182227
25MP0008004_abnormal_stomach_pH1.84831104
26MP0003011_delayed_dark_adaptation1.83802521
27MP0003806_abnormal_nucleotide_metabolis1.83242571
28MP0005000_abnormal_immune_tolerance1.82959878
29MP0006054_spinal_hemorrhage1.77147092
30MP0006082_CNS_inflammation1.75418873
31MP0010030_abnormal_orbit_morphology1.73993323
32MP0001697_abnormal_embryo_size1.73173122
33MP0003123_paternal_imprinting1.69296872
34MP0002419_abnormal_innate_immunity1.68954481
35MP0002653_abnormal_ependyma_morphology1.66396059
36MP0003984_embryonic_growth_retardation1.66229269
37MP0002086_abnormal_extraembryonic_tissu1.64156851
38MP0002405_respiratory_system_inflammati1.63975503
39MP0002088_abnormal_embryonic_growth/wei1.63331300
40MP0003566_abnormal_cell_adhesion1.62347150
41MP0002254_reproductive_system_inflammat1.59690335
42MP0010307_abnormal_tumor_latency1.57598276
43MP0009785_altered_susceptibility_to1.57460012
44MP0002085_abnormal_embryonic_tissue1.57415485
45MP0003724_increased_susceptibility_to1.56738622
46MP0005023_abnormal_wound_healing1.56735086
47MP0001533_abnormal_skeleton_physiology1.56228984
48MP0003279_aneurysm1.54072233
49MP0001764_abnormal_homeostasis1.52549025
50MP0002084_abnormal_developmental_patter1.52534835
51MP0002396_abnormal_hematopoietic_system1.52419170
52MP0002080_prenatal_lethality1.50035948
53MP0003941_abnormal_skin_development1.49227153
54MP0001968_abnormal_touch/_nociception1.42995436
55MP0000343_altered_response_to1.39742710
56MP0003950_abnormal_plasma_membrane1.39666845
57MP0002723_abnormal_immune_serum1.39070776
58MP0009333_abnormal_splenocyte_physiolog1.37856472
59MP0000465_gastrointestinal_hemorrhage1.37355928
60MP0002933_joint_inflammation1.31299084
61MP0001819_abnormal_immune_cell1.31078207
62MP0003119_abnormal_digestive_system1.30946057
63MP0002420_abnormal_adaptive_immunity1.30695016
64MP0002452_abnormal_antigen_presenting1.29191934
65MP0008438_abnormal_cutaneous_collagen1.28243832
66MP0003567_abnormal_fetal_cardiomyocyte1.25709963
67MP0005666_abnormal_adipose_tissue1.24048376
68MP0005025_abnormal_response_to1.22394066
69MP0002019_abnormal_tumor_incidence1.20657176
70MP0001545_abnormal_hematopoietic_system1.19801622
71MP0005397_hematopoietic_system_phenotyp1.19801622
72MP0004133_heterotaxia1.15938441
73MP0001873_stomach_inflammation1.15131441
74MP0000749_muscle_degeneration1.14334101
75MP0001849_ear_inflammation1.13955206
76MP0000313_abnormal_cell_death1.13684262
77MP0009384_cardiac_valve_regurgitation1.13538907
78MP0000767_abnormal_smooth_muscle1.13210147
79MP0003186_abnormal_redox_activity1.12794094
80MP0004197_abnormal_fetal_growth/weight/1.12511091
81MP0009840_abnormal_foam_cell1.11057207
82MP0001293_anophthalmia1.09827838
83MP0009697_abnormal_copulation1.09771743
84MP0004883_abnormal_blood_vessel1.09561133
85MP0004264_abnormal_extraembryonic_tissu1.09487662
86MP0009278_abnormal_bone_marrow1.08333370
87MP0000750_abnormal_muscle_regeneration1.07862202
88MP0008877_abnormal_DNA_methylation1.07170751
89MP0001800_abnormal_humoral_immune1.04430534
90MP0002295_abnormal_pulmonary_circulatio1.03949813
91MP0008469_abnormal_protein_level1.03372537
92MP0000858_altered_metastatic_potential1.02884087
93MP0003453_abnormal_keratinocyte_physiol1.02737283
94MP0000490_abnormal_crypts_of1.02683361
95MP0005395_other_phenotype1.02550122
96MP0003878_abnormal_ear_physiology1.00804105
97MP0005377_hearing/vestibular/ear_phenot1.00804105
98MP0003075_altered_response_to1.00467714
99MP0006036_abnormal_mitochondrial_physio0.98731127
100MP0001845_abnormal_inflammatory_respons0.98382429
101MP0000716_abnormal_immune_system0.98112763
102MP0003763_abnormal_thymus_physiology0.97923690
103MP0005390_skeleton_phenotype0.97645848
104MP0000516_abnormal_urinary_system0.97316531
105MP0005367_renal/urinary_system_phenotyp0.97316531
106MP0004782_abnormal_surfactant_physiolog0.97268232
107MP0004947_skin_inflammation0.96411697
108MP0008260_abnormal_autophagy0.96215255
109MP0009764_decreased_sensitivity_to0.94796199
110MP0003315_abnormal_perineum_morphology0.94317469
111MP0000358_abnormal_cell_content/0.92802253
112MP0000751_myopathy0.92643127
113MP0001853_heart_inflammation0.92616414
114MP0005451_abnormal_body_composition0.92107046
115MP0001851_eye_inflammation0.91688827
116MP0002132_abnormal_respiratory_system0.91497737
117MP0003890_abnormal_embryonic-extraembry0.91109934
118MP0002796_impaired_skin_barrier0.91015613
119MP0005076_abnormal_cell_differentiation0.90545668
120MP0004272_abnormal_basement_membrane0.89870997
121MP0002111_abnormal_tail_morphology0.87297662
122MP0001542_abnormal_bone_strength0.87202101
123MP0002722_abnormal_immune_system0.85450953
124MP0008873_increased_physiological_sensi0.84065124
125MP0003221_abnormal_cardiomyocyte_apopto0.84005949
126MP0005621_abnormal_cell_physiology0.83889925
127MP0002972_abnormal_cardiac_muscle0.82609855
128MP0005330_cardiomyopathy0.82475631
129MP0000703_abnormal_thymus_morphology0.82208893
130MP0001835_abnormal_antigen_presentation0.81581978
131MP0000627_abnormal_mammary_gland0.80949240
132MP0004084_abnormal_cardiac_muscle0.80474541
133MP0001243_abnormal_dermal_layer0.79362079
134MP0003448_altered_tumor_morphology0.79360231
135MP0002429_abnormal_blood_cell0.78503376
136MP0005164_abnormal_response_to0.77943126
137MP0002210_abnormal_sex_determination0.77694027
138MP0005647_abnormal_sex_gland0.77339248
139MP0005464_abnormal_platelet_physiology0.77247177
140MP0003638_abnormal_response/metabolism_0.77057168
141MP0005384_cellular_phenotype0.76145520
142MP0009643_abnormal_urine_homeostasis0.76088016
143MP0005501_abnormal_skin_physiology0.75131829
144MP0000428_abnormal_craniofacial_morphol0.74252195
145MP0001661_extended_life_span0.74121292
146MP0005584_abnormal_enzyme/coenzyme_acti0.73715610
147MP0000689_abnormal_spleen_morphology0.73092053
148MP0005165_increased_susceptibility_to0.73051016
149MP0005671_abnormal_response_to0.72858307
150MP0010155_abnormal_intestine_physiology0.72619453
151MP0001881_abnormal_mammary_gland0.72287916
152MP0004808_abnormal_hematopoietic_stem0.71362717
153MP0000733_abnormal_muscle_development0.71104931
154MP0001145_abnormal_male_reproductive0.70805091
155MP0002269_muscular_atrophy0.70698793
156MP0005387_immune_system_phenotype0.70612400
157MP0001790_abnormal_immune_system0.70612400
158MP0005166_decreased_susceptibility_to0.70523664
159MP0002398_abnormal_bone_marrow0.69761904
160MP0003936_abnormal_reproductive_system0.69122496
161MP0004087_abnormal_muscle_fiber0.68051912
162MP0003136_yellow_coat_color0.67941509
163MP0001216_abnormal_epidermal_layer0.67575265
164MP0005389_reproductive_system_phenotype0.66436842
165MP0000685_abnormal_immune_system0.66276218
166MP0002136_abnormal_kidney_physiology0.66234681
167MP0002277_abnormal_respiratory_mucosa0.65921616
168MP0002098_abnormal_vibrissa_morphology0.65918621
169MP0005266_abnormal_metabolism0.65179980
170MP0002060_abnormal_skin_morphology0.64963109
171MP0003828_pulmonary_edema0.64474536
172MP0005275_abnormal_skin_tensile0.64039387
173MP0000477_abnormal_intestine_morphology0.63305718

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.68404218
2Breast hypoplasia (HP:0003187)4.65414187
3Selective tooth agenesis (HP:0001592)4.44402365
4Mesangial abnormality (HP:0001966)3.86592757
5Carpal bone hypoplasia (HP:0001498)3.84865988
6Rough bone trabeculation (HP:0100670)3.79278843
7Agammaglobulinemia (HP:0004432)3.62123786
8Popliteal pterygium (HP:0009756)3.48487463
9Amniotic constriction ring (HP:0009775)3.42596370
10Abnormality of placental membranes (HP:0011409)3.42596370
11Prolonged neonatal jaundice (HP:0006579)3.40187171
12Patellar aplasia (HP:0006443)3.34772469
13Muscle fiber atrophy (HP:0100295)3.33846974
14Cerebral hypomyelination (HP:0006808)3.30874606
15Vacuolated lymphocytes (HP:0001922)3.28703830
16Absent radius (HP:0003974)3.27842215
17Premature ovarian failure (HP:0008209)3.26303637
18Impulsivity (HP:0100710)3.24267998
19Type 2 muscle fiber atrophy (HP:0003554)3.16544988
20Trismus (HP:0000211)3.16451163
21Aplasia/Hypoplasia of the patella (HP:0006498)3.15785651
22Absent forearm bone (HP:0003953)3.14737188
23Aplasia involving forearm bones (HP:0009822)3.14737188
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.13553280
25Amyloidosis (HP:0011034)3.11646302
26Microretrognathia (HP:0000308)3.09913456
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08444705
28Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08444705
29Oral leukoplakia (HP:0002745)3.07935169
30Abnormality of the anterior horn cell (HP:0006802)3.06829450
31Degeneration of anterior horn cells (HP:0002398)3.06829450
32Abnormality of macrophages (HP:0004311)2.95511641
33Ependymoma (HP:0002888)2.94930649
34Multiple enchondromatosis (HP:0005701)2.94561329
35Aplasia/hypoplasia of the humerus (HP:0006507)2.91921579
36Petechiae (HP:0000967)2.91553483
37Cervical subluxation (HP:0003308)2.85046406
38Absent thumb (HP:0009777)2.80137846
39Dry hair (HP:0011359)2.73408517
40Abnormal trabecular bone morphology (HP:0100671)2.71959237
41Abnormality of the labia minora (HP:0012880)2.71315864
42Reticulocytopenia (HP:0001896)2.68405688
43Supernumerary spleens (HP:0009799)2.64516800
44Panhypogammaglobulinemia (HP:0003139)2.63050917
45Severe combined immunodeficiency (HP:0004430)2.62311422
46Spinal muscular atrophy (HP:0007269)2.62041004
47Stenosis of the external auditory canal (HP:0000402)2.61688318
48Colon cancer (HP:0003003)2.61403620
49Dysostosis multiplex (HP:0000943)2.61221550
50Loss of speech (HP:0002371)2.60981168
51Abnormality of cells of the erythroid lineage (HP:0012130)2.59820721
52Stomatitis (HP:0010280)2.59013862
53Spastic paraparesis (HP:0002313)2.56822695
54Hypoplastic heart (HP:0001961)2.56772985
55Sparse eyelashes (HP:0000653)2.56340463
56Abnormality of the umbilical cord (HP:0010881)2.52416551
57Ureteral duplication (HP:0000073)2.50031755
58Easy fatigability (HP:0003388)2.44172277
59Short humerus (HP:0005792)2.43121368
60Type I transferrin isoform profile (HP:0003642)2.41890361
61Adactyly (HP:0009776)2.41151704
62Premature graying of hair (HP:0002216)2.37251927
63Hepatosplenomegaly (HP:0001433)2.35578663
64Meckel diverticulum (HP:0002245)2.35264512
65Aplasia of the musculature (HP:0100854)2.34164742
66Bulbar palsy (HP:0001283)2.33892928
67Autoimmune thrombocytopenia (HP:0001973)2.33867784
68Joint stiffness (HP:0001387)2.33250790
69Increased IgM level (HP:0003496)2.32188798
70Secondary amenorrhea (HP:0000869)2.31687293
71Abnormality of the preputium (HP:0100587)2.31159816
72Weak cry (HP:0001612)2.31108226
73Cholecystitis (HP:0001082)2.30858969
74Abnormal gallbladder physiology (HP:0012438)2.30858969
75Acute encephalopathy (HP:0006846)2.30423004
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29844407
77Squamous cell carcinoma (HP:0002860)2.27964266
78Abnormality of the ileum (HP:0001549)2.27950690
79Shawl scrotum (HP:0000049)2.27173881
80Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26864158
81Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26573811
82Fused cervical vertebrae (HP:0002949)2.25567165
83Abnormal number of incisors (HP:0011064)2.25467130
84Elevated erythrocyte sedimentation rate (HP:0003565)2.24412829
85Abnormality of polysaccharide metabolism (HP:0011012)2.22502692
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22502692
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22502692
88Neoplasm of the pancreas (HP:0002894)2.21254751
89Neurodegeneration (HP:0002180)2.20278446
90Acute necrotizing encephalopathy (HP:0006965)2.19304953
91Glossoptosis (HP:0000162)2.18913726
92Cellular immunodeficiency (HP:0005374)2.18181841
93Combined immunodeficiency (HP:0005387)2.17620548
94Mitochondrial inheritance (HP:0001427)2.16340184
95Abnormal protein glycosylation (HP:0012346)2.16279536
96Abnormal glycosylation (HP:0012345)2.16279536
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16279536
98Abnormal protein N-linked glycosylation (HP:0012347)2.16279536
99Absent hand (HP:0004050)2.15815949
100Atresia of the external auditory canal (HP:0000413)2.15654548
101Rhabdomyolysis (HP:0003201)2.15634665
102Abnormal number of erythroid precursors (HP:0012131)2.15298256
103Hyperglycinuria (HP:0003108)2.14938061
104Gowers sign (HP:0003391)2.14475853
105B lymphocytopenia (HP:0010976)2.14060730
106Basal cell carcinoma (HP:0002671)2.11735394
107Abnormalities of placenta or umbilical cord (HP:0001194)2.11580953
108Progressive muscle weakness (HP:0003323)2.10665080
109Hyperglycinemia (HP:0002154)2.09828553
110Macrocytic anemia (HP:0001972)2.08953150
111Renal Fanconi syndrome (HP:0001994)2.08943476
112Cleft eyelid (HP:0000625)2.07893128
113Pustule (HP:0200039)2.07741739
114Muscle fibrillation (HP:0010546)2.07107950
115Horseshoe kidney (HP:0000085)2.07027638
116Rhabdomyosarcoma (HP:0002859)2.06571411
117Rib fusion (HP:0000902)2.06378253
118Breast aplasia (HP:0100783)2.05876995
119Abnormality of the fetal cardiovascular system (HP:0010948)2.05348828
120Abnormal umbilical cord blood vessels (HP:0011403)2.05348828
121Single umbilical artery (HP:0001195)2.05348828
122Bone marrow hypocellularity (HP:0005528)2.05342038
123Urinary glycosaminoglycan excretion (HP:0003541)2.04716780
124Mucopolysacchariduria (HP:0008155)2.04716780
125Abnormal mitochondria in muscle tissue (HP:0008316)2.03388713
126Tracheoesophageal fistula (HP:0002575)2.03040734
127Death in infancy (HP:0001522)2.01874144
128Nausea (HP:0002018)2.00544118
129Congenital, generalized hypertrichosis (HP:0004540)2.00020964
130Autoimmune hemolytic anemia (HP:0001890)1.99943333
131Lactic acidosis (HP:0003128)1.99735353
132Pili torti (HP:0003777)1.99538026
133Increased IgE level (HP:0003212)1.98418751
134Concave nail (HP:0001598)1.98225577
135Medulloblastoma (HP:0002885)1.97834781
136Aplasia/Hypoplasia involving the musculature (HP:0001460)1.97799159
137Facial diplegia (HP:0001349)1.96898840
138Abnormality of the neuromuscular junction (HP:0003398)1.96579792
139Fatigable weakness (HP:0003473)1.96579792
140Natal tooth (HP:0000695)1.96263887
141Aplasia/Hypoplasia of the uvula (HP:0010293)1.96094223
142Hepatocellular necrosis (HP:0001404)1.96014468
143Hypoplasia of the radius (HP:0002984)1.95109706
144Protrusio acetabuli (HP:0003179)1.94633417
145Beaking of vertebral bodies (HP:0004568)1.94284370
146Tongue fasciculations (HP:0001308)1.93758015
147Esophageal atresia (HP:0002032)1.93668896
148Systemic lupus erythematosus (HP:0002725)1.93129006
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.91996014
150Breech presentation (HP:0001623)1.91629197
151Diaphragmatic weakness (HP:0009113)1.90044236
152Recurrent abscess formation (HP:0002722)1.89965986
153Hypoplastic left heart (HP:0004383)1.89861109
154Vertebral compression fractures (HP:0002953)1.88575961
155Myelodysplasia (HP:0002863)1.88437239
156Personality changes (HP:0000751)1.87890504
157Hepatic necrosis (HP:0002605)1.87726880
158Hyperammonemia (HP:0001987)1.86563711
159IgM deficiency (HP:0002850)1.86032470
160Lymphopenia (HP:0001888)1.85605519
1613-Methylglutaconic aciduria (HP:0003535)1.84777777
162Gonadal dysgenesis (HP:0000133)1.84436696
163Nail dystrophy (HP:0008404)1.84118402
164Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83060192
165Dicarboxylic aciduria (HP:0003215)1.83060192
166Atrophy/Degeneration involving motor neurons (HP:0007373)1.83035539
167CNS hypomyelination (HP:0003429)1.81441270
168Stridor (HP:0010307)1.81403252
169Oligodactyly (HP:0012165)1.80728208
170Increased CSF lactate (HP:0002490)1.78985157
171Rectovaginal fistula (HP:0000143)1.78611500
172Rectal fistula (HP:0100590)1.78611500
173Reduced subcutaneous adipose tissue (HP:0003758)1.78491715
174Abdominal situs inversus (HP:0003363)1.78069264
175Abnormality of abdominal situs (HP:0011620)1.78069264
176Chromsome breakage (HP:0040012)1.77580763
177Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76378995
178Metaphyseal cupping (HP:0003021)1.76091638
179Areflexia of lower limbs (HP:0002522)1.75987092
180Aplastic anemia (HP:0001915)1.75672364
181Facial cleft (HP:0002006)1.74957464
182Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74701648
183Small intestinal stenosis (HP:0012848)1.73968192
184Duodenal stenosis (HP:0100867)1.73968192
185Prominent nose (HP:0000448)1.72669846
186Patent foramen ovale (HP:0001655)1.72596671
187Recurrent fungal infections (HP:0002841)1.71351944
188Increased muscle lipid content (HP:0009058)1.71149985
189CNS demyelination (HP:0007305)1.70320477
190Biconcave vertebral bodies (HP:0004586)1.68256285
191Spondylolisthesis (HP:0003302)1.68231688
192Abnormality of B cell number (HP:0010975)1.67184117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.22895367
2WEE14.29784491
3VRK23.64115949
4EPHA23.09257111
5PBK2.83952817
6PLK42.82410985
7MUSK2.77436016
8ERN12.67829332
9EIF2AK12.65834480
10NME22.65390078
11TSSK62.60200533
12NEK22.58636985
13NEK12.49266676
14FES2.38832330
15TNK22.33086840
16TTK2.32400030
17MAP3K132.31166672
18RPS6KB22.11087940
19MAP3K122.06505347
20TESK12.06198740
21CDC72.02068593
22RPS6KA41.99465206
23LATS21.94074914
24PLK11.93514056
25MYLK1.81332352
26TESK21.80606795
27CDK71.74259272
28TAOK31.70946245
29TBK11.66955969
30CDK121.65640450
31SRPK11.62925004
32STK101.59345638
33DYRK31.57600941
34ACVR1B1.52328353
35PLK31.51240163
36CHEK21.47003495
37LMTK21.45938976
38ZAK1.45188839
39AKT31.40658332
40CSF1R1.40633816
41STK161.35847567
42TGFBR21.35009082
43STK38L1.34822853
44AURKB1.32959489
45ILK1.32443714
46MAP3K81.31810299
47CDK41.30945262
48TRIB31.30628743
49MAP3K141.30255282
50KDR1.29969032
51BRSK21.27833396
52MAPKAPK31.24754829
53LIMK11.23040804
54EIF2AK31.22983785
55CCNB11.22599743
56MAP3K111.22535896
57AURKA1.22534779
58ALK1.20458406
59PNCK1.20407254
60PAK41.16075561
61PIM11.10985465
62CDK81.10403929
63DAPK11.08607021
64PIM21.04194130
65ABL21.03269261
66PRKCI1.02518955
67MAP3K30.97373298
68MKNK20.96254446
69ATR0.95354805
70MAP4K20.93340765
71CHEK10.90322713
72MKNK10.87631747
73BMX0.85151375
74VRK10.84628364
75PAK10.84065088
76HCK0.83408545
77PRKCQ0.83299004
78PRKD30.83110923
79CSK0.82251126
80FGR0.81444294
81PTK2B0.81262877
82CDK90.79135721
83KIT0.79030626
84JAK10.77524656
85PDK20.76054825
86MST40.76046222
87SIK30.75182997
88DAPK30.74122662
89BRSK10.73987295
90LATS10.73499867
91IKBKE0.70037237
92MAP2K30.69799392
93BMPR1B0.69707332
94BLK0.69165402
95CDK20.68566932
96NME10.68332795
97MOS0.68303910
98JAK30.67878264
99MTOR0.67832451
100ERBB40.66814858
101CDK60.66246064
102TGFBR10.66188102
103PDK10.65368719
104TRIM280.65132182
105DDR20.63425211
106NEK60.62555070
107IRAK30.62064185
108LRRK20.61340229
109STK30.60892157
110MAP3K50.59737442
111BCKDK0.59181088
112MELK0.59110527
113CSNK2A20.58369995
114MAP4K10.58354502
115PASK0.58330738
116LYN0.57232902
117TAOK20.57184196
118RIPK10.57058254
119EEF2K0.56643148
120CSNK2A10.56623884
121PKN20.54660838
122PINK10.53815949
123BRAF0.53775953
124ROCK10.53612883
125SYK0.52221696
126IKBKB0.51146564
127ATM0.50202095
128PDK40.49806518
129PDK30.49806518
130PIK3CG0.49213390
131ARAF0.48290099
132GRK10.47908630
133ERBB30.47282676
134MAPKAPK20.46959186
135TYK20.46828993
136ZAP700.46640755
137LCK0.43226036
138PRKG20.42886836
139NLK0.42817062
140CSNK1E0.42711384
141TIE10.42630544
142TAOK10.42079335
143DYRK20.41715388
144MAPK40.41224502
145PAK20.40454818
146DYRK1B0.40445785
147CDK10.40383528
148FGFR40.40321873
149TLK10.38966508
150PDPK10.38146702
151ABL10.37853410
152GRK60.37601483
153TAF10.36264769
154EIF2AK20.35857877
155AKT20.35338258
156SMG10.35179550
157MAP2K20.35152228
158CHUK0.34884287
159ROCK20.34833922
160BTK0.34511343
161INSR0.34341691
162PRKD20.34218752
163RAF10.33954735
164FGFR10.33231179
165RPS6KA50.33168352
166STK40.32175031
167TYRO30.30313231
168MARK30.26433263

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000624.78192853
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28209420
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010404.25807682
4Proteasome_Homo sapiens_hsa030503.84604710
5RNA polymerase_Homo sapiens_hsa030203.84364292
6DNA replication_Homo sapiens_hsa030303.59725843
7RNA transport_Homo sapiens_hsa030133.35988992
8Ribosome_Homo sapiens_hsa030103.30143328
9Mismatch repair_Homo sapiens_hsa034303.29800460
10Spliceosome_Homo sapiens_hsa030402.88154498
11Vitamin B6 metabolism_Homo sapiens_hsa007502.66956889
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.60180470
13Nucleotide excision repair_Homo sapiens_hsa034202.42184811
14Base excision repair_Homo sapiens_hsa034102.42089204
15Other glycan degradation_Homo sapiens_hsa005112.40535596
16Cell cycle_Homo sapiens_hsa041102.33546970
17Pyrimidine metabolism_Homo sapiens_hsa002402.32307028
18Pyruvate metabolism_Homo sapiens_hsa006202.28512680
19Fatty acid metabolism_Homo sapiens_hsa012122.18496433
20Homologous recombination_Homo sapiens_hsa034402.12655017
21Glycosaminoglycan degradation_Homo sapiens_hsa005312.09652252
22p53 signaling pathway_Homo sapiens_hsa041152.09138654
23Asthma_Homo sapiens_hsa053102.03228735
24One carbon pool by folate_Homo sapiens_hsa006701.98430416
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.95104317
26Propanoate metabolism_Homo sapiens_hsa006401.85656156
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77739368
28Basal transcription factors_Homo sapiens_hsa030221.76016075
29Oxidative phosphorylation_Homo sapiens_hsa001901.74887158
30Fanconi anemia pathway_Homo sapiens_hsa034601.73053173
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69384556
32Peroxisome_Homo sapiens_hsa041461.55769364
33PPAR signaling pathway_Homo sapiens_hsa033201.51373380
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51246538
35Folate biosynthesis_Homo sapiens_hsa007901.49834359
36RNA degradation_Homo sapiens_hsa030181.43928696
37mRNA surveillance pathway_Homo sapiens_hsa030151.43499502
38Parkinsons disease_Homo sapiens_hsa050121.42649536
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37036612
40Epstein-Barr virus infection_Homo sapiens_hsa051691.35723073
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34213691
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27861517
43Purine metabolism_Homo sapiens_hsa002301.24277268
44Graft-versus-host disease_Homo sapiens_hsa053321.21669589
45Sulfur relay system_Homo sapiens_hsa041221.21484205
46N-Glycan biosynthesis_Homo sapiens_hsa005101.20336293
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.19665042
48Regulation of autophagy_Homo sapiens_hsa041401.19550320
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10317476
50Lysosome_Homo sapiens_hsa041421.10309751
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08955359
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08769891
53Antigen processing and presentation_Homo sapiens_hsa046121.07714821
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03988193
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.02116058
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01461460
57Biosynthesis of amino acids_Homo sapiens_hsa012300.99077661
58Pentose phosphate pathway_Homo sapiens_hsa000300.98972870
59Herpes simplex infection_Homo sapiens_hsa051680.93794211
60Non-homologous end-joining_Homo sapiens_hsa034500.91484129
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84969569
62Rheumatoid arthritis_Homo sapiens_hsa053230.84293510
63Huntingtons disease_Homo sapiens_hsa050160.84220415
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.83936527
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82564610
66Hippo signaling pathway_Homo sapiens_hsa043900.82450516
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82446126
68Fructose and mannose metabolism_Homo sapiens_hsa000510.81674239
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80034315
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79855135
71Vibrio cholerae infection_Homo sapiens_hsa051100.78372571
72Oocyte meiosis_Homo sapiens_hsa041140.77391073
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.77363914
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71938831
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71459021
76HTLV-I infection_Homo sapiens_hsa051660.71153041
77TGF-beta signaling pathway_Homo sapiens_hsa043500.68208944
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66656511
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66243138
80Viral carcinogenesis_Homo sapiens_hsa052030.65001162
81Small cell lung cancer_Homo sapiens_hsa052220.64060656
82Alzheimers disease_Homo sapiens_hsa050100.64026127
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63876329
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63764505
85Glutathione metabolism_Homo sapiens_hsa004800.62501763
86Fatty acid degradation_Homo sapiens_hsa000710.60922522
87Staphylococcus aureus infection_Homo sapiens_hsa051500.59484828
88MicroRNAs in cancer_Homo sapiens_hsa052060.58947476
89Adherens junction_Homo sapiens_hsa045200.58776053
90Osteoclast differentiation_Homo sapiens_hsa043800.57452841
91Malaria_Homo sapiens_hsa051440.57425294
92Collecting duct acid secretion_Homo sapiens_hsa049660.57217356
93Leishmaniasis_Homo sapiens_hsa051400.56042987
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55601181
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55527507
96Tuberculosis_Homo sapiens_hsa051520.55061415
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.53535283
98Basal cell carcinoma_Homo sapiens_hsa052170.52997476
99Sulfur metabolism_Homo sapiens_hsa009200.52727924
100Viral myocarditis_Homo sapiens_hsa054160.51761546
101Galactose metabolism_Homo sapiens_hsa000520.51590967
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50866407
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.49984916
104African trypanosomiasis_Homo sapiens_hsa051430.49867099
105Steroid biosynthesis_Homo sapiens_hsa001000.49689564
106Thyroid cancer_Homo sapiens_hsa052160.49613140
107Apoptosis_Homo sapiens_hsa042100.49528790
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49358104
109Measles_Homo sapiens_hsa051620.48000878
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46339674
111Primary immunodeficiency_Homo sapiens_hsa053400.45603669
112Selenocompound metabolism_Homo sapiens_hsa004500.45168228
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45100152
114HIF-1 signaling pathway_Homo sapiens_hsa040660.45038373
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.44949695
116mTOR signaling pathway_Homo sapiens_hsa041500.44815479
117Phototransduction_Homo sapiens_hsa047440.44253677
118Allograft rejection_Homo sapiens_hsa053300.44034311
119Vitamin digestion and absorption_Homo sapiens_hsa049770.43719979
120Shigellosis_Homo sapiens_hsa051310.43375132
121Hedgehog signaling pathway_Homo sapiens_hsa043400.42824557
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.42211663
123Notch signaling pathway_Homo sapiens_hsa043300.41454712
124Hematopoietic cell lineage_Homo sapiens_hsa046400.41094373
125Carbon metabolism_Homo sapiens_hsa012000.41074763
126Legionellosis_Homo sapiens_hsa051340.41043261
127Endocytosis_Homo sapiens_hsa041440.40913282
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40425153
129Arginine and proline metabolism_Homo sapiens_hsa003300.40137134
130Chemical carcinogenesis_Homo sapiens_hsa052040.39359685
131Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38830405
132Arachidonic acid metabolism_Homo sapiens_hsa005900.38501632
133beta-Alanine metabolism_Homo sapiens_hsa004100.35377269
134Tight junction_Homo sapiens_hsa045300.35307856
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34490118
136Influenza A_Homo sapiens_hsa051640.33370994
137Glycerolipid metabolism_Homo sapiens_hsa005610.32397546
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32105602
139Pathways in cancer_Homo sapiens_hsa052000.30687900
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29816090
141Pertussis_Homo sapiens_hsa051330.29505667
142Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28057654
143Bladder cancer_Homo sapiens_hsa052190.27828572
144Linoleic acid metabolism_Homo sapiens_hsa005910.27546213
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23166693
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19556557
147Autoimmune thyroid disease_Homo sapiens_hsa053200.19490093
148Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.18406616
149Acute myeloid leukemia_Homo sapiens_hsa052210.18290315
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17990629
151Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.17952640
152Hepatitis B_Homo sapiens_hsa051610.16670265
153Regulation of actin cytoskeleton_Homo sapiens_hsa048100.15788560
154Prostate cancer_Homo sapiens_hsa052150.15611653
155Metabolic pathways_Homo sapiens_hsa011000.15493690
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.15080644

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