GATSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.18757184
2muscle filament sliding (GO:0030049)8.18757184
3sarcoplasmic reticulum calcium ion transport (GO:0070296)7.81646491
4actin-mediated cell contraction (GO:0070252)6.80520580
5skeletal muscle contraction (GO:0003009)6.18737467
6myofibril assembly (GO:0030239)5.98751280
7sarcomere organization (GO:0045214)5.95009001
8regulation of skeletal muscle contraction (GO:0014819)5.67936911
9response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.59064984
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57168564
11regulation of relaxation of muscle (GO:1901077)5.35127508
12actin filament-based movement (GO:0030048)5.29806965
13striated muscle contraction (GO:0006941)5.23452920
14cardiac myofibril assembly (GO:0055003)5.05209353
15synaptic vesicle maturation (GO:0016188)5.04267527
16response to muscle activity (GO:0014850)4.99203175
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.95349712
18response to inactivity (GO:0014854)4.79413828
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.63962204
20regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.57730284
21locomotory exploration behavior (GO:0035641)4.54988237
22plasma membrane repair (GO:0001778)4.54985412
23actomyosin structure organization (GO:0031032)4.52918994
24cardiac muscle hypertrophy (GO:0003300)4.51804932
25skeletal muscle fiber development (GO:0048741)4.47669220
26regulation of synaptic vesicle exocytosis (GO:2000300)4.47631464
27cardiac muscle contraction (GO:0060048)4.44634733
28creatine metabolic process (GO:0006600)4.31597170
29synaptic vesicle exocytosis (GO:0016079)4.30949699
30skeletal muscle adaptation (GO:0043501)4.30476449
31striated muscle hypertrophy (GO:0014897)4.26523073
32positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.12725825
33muscle contraction (GO:0006936)4.04362355
34myotube cell development (GO:0014904)4.02882866
35regulation of synaptic vesicle transport (GO:1902803)3.98516440
36vocalization behavior (GO:0071625)3.97875165
37glutamate secretion (GO:0014047)3.96476017
38regulation of actin filament-based movement (GO:1903115)3.85968972
39striated muscle adaptation (GO:0014888)3.84972844
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.80325677
41synaptic vesicle docking involved in exocytosis (GO:0016081)3.76269290
42glycine transport (GO:0015816)3.75532078
43positive regulation of synaptic transmission, GABAergic (GO:0032230)3.72057408
44neurotransmitter secretion (GO:0007269)3.72018129
45regulation of glutamate receptor signaling pathway (GO:1900449)3.69859187
46muscle hypertrophy (GO:0014896)3.68740116
47glycogen catabolic process (GO:0005980)3.65573691
48muscle system process (GO:0003012)3.62751012
49cardiac muscle adaptation (GO:0014887)3.60757864
50cardiac muscle hypertrophy in response to stress (GO:0014898)3.60757864
51muscle hypertrophy in response to stress (GO:0003299)3.60757864
52neuronal action potential propagation (GO:0019227)3.60657158
53adult heart development (GO:0007512)3.58896590
54NADH metabolic process (GO:0006734)3.57317362
55activation of protein kinase A activity (GO:0034199)3.56633424
56regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.56388189
57muscle cell cellular homeostasis (GO:0046716)3.53720613
58myoblast fusion (GO:0007520)3.53146283
59detection of calcium ion (GO:0005513)3.52114114
60regulation of NFAT protein import into nucleus (GO:0051532)3.51718564
61carnitine shuttle (GO:0006853)3.48165536
62membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.45119899
63neuron cell-cell adhesion (GO:0007158)3.44243875
64glucan catabolic process (GO:0009251)3.41266521
65regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.41089918
66dendritic spine morphogenesis (GO:0060997)3.38092102
67protein localization to synapse (GO:0035418)3.37040471
68layer formation in cerebral cortex (GO:0021819)3.35155192
69regulation of vesicle fusion (GO:0031338)3.34938208
70muscle fiber development (GO:0048747)3.31274210
71exploration behavior (GO:0035640)3.29974979
72regulation of neuronal synaptic plasticity (GO:0048168)3.29269695
73regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.28465665
74regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26759128
75cellular polysaccharide catabolic process (GO:0044247)3.26019173
76ionotropic glutamate receptor signaling pathway (GO:0035235)3.24612871
77muscle organ development (GO:0007517)3.22837462
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21815430
79regulation of synapse structural plasticity (GO:0051823)3.21556195
80muscle structure development (GO:0061061)3.20833421
81regulation of calcium ion-dependent exocytosis (GO:0017158)3.18534885
82regulation of long-term neuronal synaptic plasticity (GO:0048169)3.18333681
83positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.18221513
84myotube differentiation (GO:0014902)3.17472932
85regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.17345400
86syncytium formation by plasma membrane fusion (GO:0000768)3.17330012
87cardiac muscle cell development (GO:0055013)3.16835293
88insulin secretion (GO:0030073)3.16055610
89positive regulation of vesicle fusion (GO:0031340)3.15438918
90cell-substrate adherens junction assembly (GO:0007045)3.14259111
91focal adhesion assembly (GO:0048041)3.14259111
92regulation of sarcomere organization (GO:0060297)3.12855064
93chemosensory behavior (GO:0007635)3.12013442
94skeletal muscle tissue development (GO:0007519)3.11206418
95synaptic transmission, glutamatergic (GO:0035249)3.08344517
96proline transport (GO:0015824)3.07843130
97muscle adaptation (GO:0043500)3.07057383
98neurotransmitter transport (GO:0006836)3.06816195
99regulation of cell communication by electrical coupling (GO:0010649)3.06239069
100cardiac cell development (GO:0055006)3.06141764
101glycogen biosynthetic process (GO:0005978)3.05039069
102glucan biosynthetic process (GO:0009250)3.05039069
103positive regulation of membrane potential (GO:0045838)3.04258880
104cellular potassium ion homeostasis (GO:0030007)3.04115304
105gamma-aminobutyric acid transport (GO:0015812)3.03228239
106innervation (GO:0060384)3.00543330
107negative regulation of cell size (GO:0045792)2.99592935
108cerebellar Purkinje cell layer development (GO:0021680)2.98827403
109cell communication by electrical coupling (GO:0010644)2.98460221
110regulation of myoblast differentiation (GO:0045661)2.98408574
111long-term memory (GO:0007616)2.96127761
112adherens junction assembly (GO:0034333)2.95890238
113membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95619415
114neuromuscular process controlling posture (GO:0050884)2.95488360
115negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95414532
116striated muscle cell development (GO:0055002)2.91051994
117respiratory system process (GO:0003016)2.88991953
118cerebellar Purkinje cell differentiation (GO:0021702)2.88937907
119glycogen metabolic process (GO:0005977)2.87944085
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87751549
121polysaccharide catabolic process (GO:0000272)2.87090507
122muscle tissue morphogenesis (GO:0060415)2.86831464
123COPI coating of Golgi vesicle (GO:0048205)2.86595496
124Golgi transport vesicle coating (GO:0048200)2.86595496
125suckling behavior (GO:0001967)2.86437061
126dendrite morphogenesis (GO:0048813)2.85702935
127neuron-neuron synaptic transmission (GO:0007270)2.85240155
128cardiac muscle tissue morphogenesis (GO:0055008)2.85104125
129positive regulation of myotube differentiation (GO:0010831)2.85073172
130regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.84226664
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.83436139
132negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.82439080
133sodium ion export (GO:0071436)2.82204601
134striated muscle atrophy (GO:0014891)2.81972334
135glucan metabolic process (GO:0044042)2.81540641
136cellular glucan metabolic process (GO:0006073)2.81540641
137cellular response to glucagon stimulus (GO:0071377)2.81345501
138regulation of neurotransmitter secretion (GO:0046928)2.80355767
139membrane depolarization during action potential (GO:0086010)2.80006491
140regulation of skeletal muscle cell differentiation (GO:2001014)2.79133473
141peptidyl-lysine dimethylation (GO:0018027)2.78828061
142regulation of striated muscle contraction (GO:0006942)2.78768261
143regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78600403
144neurotransmitter-gated ion channel clustering (GO:0072578)2.77901805
145negative regulation of potassium ion transmembrane transport (GO:1901380)2.75901693
146glutamate receptor signaling pathway (GO:0007215)2.75653937
147positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75186276
148regulation of the force of heart contraction (GO:0002026)2.74831106
149response to epinephrine (GO:0071871)2.74765526
150positive regulation of insulin secretion (GO:0032024)2.74521146
151regulation of ARF protein signal transduction (GO:0032012)2.74450318
152signal release (GO:0023061)2.74432901
153potassium ion import (GO:0010107)2.71996323
154vesicle transport along microtubule (GO:0047496)2.71731399
155neuron recognition (GO:0008038)2.71340863
156gluconeogenesis (GO:0006094)2.68312056
157regulation of myotube differentiation (GO:0010830)2.67966739
158regulation of neurotransmitter levels (GO:0001505)2.67900738
159regulation of postsynaptic membrane potential (GO:0060078)2.67836458
160regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67711698
161regulation of calcium ion transmembrane transport (GO:1903169)2.67589509
162regulation of calcium ion transmembrane transporter activity (GO:1901019)2.67589509
1632-oxoglutarate metabolic process (GO:0006103)2.67559141
164transmission of nerve impulse (GO:0019226)2.66720643
165membrane repolarization during action potential (GO:0086011)2.66615974
166neuromuscular junction development (GO:0007528)2.66205197
167synaptic vesicle endocytosis (GO:0048488)2.65907892
168postsynaptic membrane organization (GO:0001941)2.65682908
169positive regulation of exocytosis (GO:0045921)2.65488698
170protein targeting to plasma membrane (GO:0072661)2.65416828
171regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.65372535
172neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.65058568
173neuronal ion channel clustering (GO:0045161)2.63773311
174response to pheromone (GO:0019236)2.63763593
175muscle cell development (GO:0055001)2.63578496
176regulation of exocytosis (GO:0017157)2.63133008
177mechanosensory behavior (GO:0007638)2.62985554
178regulation of synaptic transmission, GABAergic (GO:0032228)2.61263450
179regulation of skeletal muscle fiber development (GO:0048742)2.59994329
180membrane repolarization (GO:0086009)2.59722057
181peptide hormone processing (GO:0016486)2.58651301
182positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.58637768
183regulation of insulin secretion (GO:0050796)2.58359036
184neuromuscular process controlling balance (GO:0050885)2.58148680
185regulation of synaptic plasticity (GO:0048167)2.57604224
186peptide hormone secretion (GO:0030072)2.57276533
187muscle cell fate commitment (GO:0042693)2.56429526
188carnitine transmembrane transport (GO:1902603)2.56262490
189fatty acid transmembrane transport (GO:1902001)2.55496571
190membrane hyperpolarization (GO:0060081)2.55430074
191dendritic spine organization (GO:0097061)2.55048425
192auditory behavior (GO:0031223)2.54824939
193potassium ion homeostasis (GO:0055075)2.54720875
194regulation of neurotransmitter transport (GO:0051588)2.54484486
195positive regulation of potassium ion transport (GO:0043268)2.53056345
196long-term synaptic potentiation (GO:0060291)2.52936706
197positive regulation of potassium ion transmembrane transport (GO:1901381)2.51940484
198organelle transport along microtubule (GO:0072384)2.51418385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.00341988
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97307400
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85599779
4GBX2_23144817_ChIP-Seq_PC3_Human2.82275820
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81871382
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68628683
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.50009231
8SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49227992
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47769260
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47413071
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44503594
12DROSHA_22980978_ChIP-Seq_HELA_Human2.41400415
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40556093
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40556093
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40234341
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.40109513
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39553641
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32878427
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26715156
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.26584764
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.26221962
22ESR2_21235772_ChIP-Seq_MCF-7_Human2.25384738
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.22890387
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19563708
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17403047
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15901539
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.13283070
28* TBX20_22328084_ChIP-Seq_HEART_Mouse2.09326536
29* TBX20_22080862_ChIP-Seq_HEART_Mouse2.09326536
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07686643
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.04037419
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.01193354
33TCF7_22412390_ChIP-Seq_EML_Mouse1.99795830
34KDM2B_26808549_Chip-Seq_DND41_Human1.98948111
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96516882
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92525797
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89594875
38NFIB_24661679_ChIP-Seq_LUNG_Mouse1.84590835
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84017491
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81533360
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80982934
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75364288
43RACK7_27058665_Chip-Seq_MCF-7_Human1.74647354
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.70404606
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70390619
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69765469
47LXR_22292898_ChIP-Seq_THP-1_Human1.65406595
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62851497
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58440627
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58362828
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56583309
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.56234738
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54595169
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54332686
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52240193
56ZNF263_19887448_ChIP-Seq_K562_Human1.51389551
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50455420
58SMAD4_21799915_ChIP-Seq_A2780_Human1.49494797
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.48650519
60CLOCK_20551151_ChIP-Seq_293T_Human1.48280244
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46628898
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45368467
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.44607358
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43359094
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42094806
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40490173
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39662206
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39610278
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38862354
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.38255610
71CREB1_26743006_Chip-Seq_LNCaP_Human1.37292202
72ZNF274_21170338_ChIP-Seq_K562_Hela1.36627104
73CTCF_27219007_Chip-Seq_Bcells_Human1.36523870
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34036296
75IGF1R_20145208_ChIP-Seq_DFB_Human1.32886365
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31903552
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.31398044
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31095588
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.30903277
80AR_21572438_ChIP-Seq_LNCaP_Human1.29511407
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26972132
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26781186
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25725663
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.25179314
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25058092
86STAT3_23295773_ChIP-Seq_U87_Human1.25004463
87GATA1_22025678_ChIP-Seq_K562_Human1.24785744
88AR_19668381_ChIP-Seq_PC3_Human1.24169573
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.24075635
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.22651584
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22546437
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.22114839
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22101193
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21956588
95GATA1_19941826_ChIP-Seq_K562_Human1.19544692
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.19189784
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18905826
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18371075
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17945237
100MYC_22102868_ChIP-Seq_BL_Human1.17712368
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16016255
102GATA4_21415370_ChIP-Seq_HL-1_Mouse1.15362919
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.13808855
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13418271
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12520060
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.11865467
107KDM2B_26808549_Chip-Seq_K562_Human1.11746721
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11429072
109P300_19829295_ChIP-Seq_ESCs_Human1.11166426
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.09406577
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09260869
112TP53_23651856_ChIP-Seq_MEFs_Mouse1.08936005
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08811301
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07074854
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07073165
116YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06966410
117* CBX2_27304074_Chip-Seq_ESCs_Mouse1.06872486
118RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06853990
119UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06112507
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05949272
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05878911
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05721835
123VDR_21846776_ChIP-Seq_THP-1_Human1.05386647
124* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04679541
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04595576
126AR_25329375_ChIP-Seq_VCAP_Human1.04418153
127ESR1_21235772_ChIP-Seq_MCF-7_Human1.04350226
128* SMC4_20622854_ChIP-Seq_HELA_Human1.04128346
129FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04015704
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03935134
131TCF4_23295773_ChIP-Seq_U87_Human1.02066190
132SMAD4_21741376_ChIP-Seq_HESCs_Human1.01970986
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00473918
134GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00116209
135ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00043159
136RING1B_27294783_Chip-Seq_NPCs_Mouse0.99618935
137STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98642806
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98637796
139TAF15_26573619_Chip-Seq_HEK293_Human0.98223195
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.98045023
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97951932
142TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97682014
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.97538774
144* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97275260
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.97200303
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97012254
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96346655
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.95911896
149ARNT_22903824_ChIP-Seq_MCF-7_Human0.94798775
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.94769268
151RNF2_27304074_Chip-Seq_NSC_Mouse0.94303757
152AHR_22903824_ChIP-Seq_MCF-7_Human0.93625116
153STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92277486
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91554261
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90966890
156* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89722359
157VDR_22108803_ChIP-Seq_LS180_Human0.88923779
158TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88646378
159POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87675943
160RUNX2_22187159_ChIP-Seq_PCA_Human0.87281141
161DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86070185
162* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85506183
163NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85260479
164TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84591867
165GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83168474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.31759754
2MP0000749_muscle_degeneration5.18720204
3MP0004859_abnormal_synaptic_plasticity4.67512957
4MP0004270_analgesia3.78759334
5MP0004036_abnormal_muscle_relaxation3.49683699
6MP0003635_abnormal_synaptic_transmissio3.22443504
7MP0004087_abnormal_muscle_fiber3.19464210
8MP0002106_abnormal_muscle_physiology3.12742250
9MP0000759_abnormal_skeletal_muscle3.07871981
10MP0003880_abnormal_central_pattern2.99142713
11MP0002909_abnormal_adrenal_gland2.95961450
12MP0002269_muscular_atrophy2.90536987
13MP0009780_abnormal_chondrocyte_physiolo2.87161632
14MP0000013_abnormal_adipose_tissue2.86267788
15MP0005451_abnormal_body_composition2.80616165
16MP0000750_abnormal_muscle_regeneration2.77904372
17MP0005369_muscle_phenotype2.72063526
18MP0004130_abnormal_muscle_cell2.72046335
19MP0009745_abnormal_behavioral_response2.56264241
20MP0002332_abnormal_exercise_endurance2.51889289
21MP0002063_abnormal_learning/memory/cond2.45355241
22MP0005645_abnormal_hypothalamus_physiol2.44573254
23MP0002064_seizures2.44156348
24MP0009046_muscle_twitch2.43644348
25MP0004084_abnormal_cardiac_muscle2.43006105
26MP0002734_abnormal_mechanical_nocicepti2.42972062
27MP0000733_abnormal_muscle_development2.32961303
28MP0005620_abnormal_muscle_contractility2.30007467
29MP0003122_maternal_imprinting2.25628223
30MP0005330_cardiomyopathy2.24350405
31MP0002572_abnormal_emotion/affect_behav2.20881634
32MP0003183_abnormal_peptide_metabolism2.16783526
33MP0003283_abnormal_digestive_organ2.15011226
34MP0005423_abnormal_somatic_nervous2.14154230
35MP0002837_dystrophic_cardiac_calcinosis2.13931777
36MP0004043_abnormal_pH_regulation2.13681801
37MP0002272_abnormal_nervous_system2.13255334
38MP0001968_abnormal_touch/_nociception2.02131749
39MP0002108_abnormal_muscle_morphology2.00004272
40MP0005379_endocrine/exocrine_gland_phen1.90593238
41MP0001486_abnormal_startle_reflex1.89328702
42MP0002733_abnormal_thermal_nociception1.85659187
43MP0010630_abnormal_cardiac_muscle1.82499452
44MP0004145_abnormal_muscle_electrophysio1.79387388
45MP0004510_myositis1.79007892
46MP0003705_abnormal_hypodermis_morpholog1.77541358
47MP0010386_abnormal_urinary_bladder1.73318740
48MP0005646_abnormal_pituitary_gland1.71019478
49MP0001970_abnormal_pain_threshold1.69804203
50MP0003787_abnormal_imprinting1.68998237
51MP0002127_abnormal_cardiovascular_syste1.67908618
52MP0006138_congestive_heart_failure1.67157229
53MP0002972_abnormal_cardiac_muscle1.66403288
54MP0008569_lethality_at_weaning1.63878780
55MP0001501_abnormal_sleep_pattern1.63466726
56MP0002184_abnormal_innervation1.60757025
57MP0002822_catalepsy1.59799162
58MP0008961_abnormal_basal_metabolism1.58385509
59MP0002735_abnormal_chemical_nociception1.57763148
60MP0002557_abnormal_social/conspecific_i1.57332599
61MP0002067_abnormal_sensory_capabilities1.56563014
62MP0003879_abnormal_hair_cell1.56009616
63MP0002638_abnormal_pupillary_reflex1.55611511
64MP0001944_abnormal_pancreas_morphology1.52899800
65MP0002693_abnormal_pancreas_physiology1.52209029
66MP0004858_abnormal_nervous_system1.50160923
67MP0001440_abnormal_grooming_behavior1.48143319
68MP0000955_abnormal_spinal_cord1.43441206
69MP0001502_abnormal_circadian_rhythm1.41357037
70MP0003195_calcinosis1.40448976
71MP0000003_abnormal_adipose_tissue1.38751600
72MP0004811_abnormal_neuron_physiology1.38337654
73MP0006072_abnormal_retinal_apoptosis1.37738553
74MP0004924_abnormal_behavior1.37505003
75MP0005386_behavior/neurological_phenoty1.37505003
76MP0003221_abnormal_cardiomyocyte_apopto1.34179044
77MP0004885_abnormal_endolymph1.33958912
78MP0000778_abnormal_nervous_system1.33600574
79MP0002736_abnormal_nociception_after1.29977796
80MP0005076_abnormal_cell_differentiation1.29632734
81MP0004185_abnormal_adipocyte_glucose1.28773427
82MP0006276_abnormal_autonomic_nervous1.28367353
83MP0003329_amyloid_beta_deposits1.24490306
84MP0001661_extended_life_span1.22052036
85MP0002877_abnormal_melanocyte_morpholog1.21745537
86MP0002882_abnormal_neuron_morphology1.21697354
87MP0000751_myopathy1.21066876
88MP0004484_altered_response_of1.20698476
89MP0000678_abnormal_parathyroid_gland1.20123755
90MP0002066_abnormal_motor_capabilities/c1.19436274
91MP0003633_abnormal_nervous_system1.18552497
92MP0002234_abnormal_pharynx_morphology1.16056323
93MP0001544_abnormal_cardiovascular_syste1.15935203
94MP0005385_cardiovascular_system_phenoty1.15935203
95MP0001984_abnormal_olfaction1.15102202
96MP0000631_abnormal_neuroendocrine_gland1.14028746
97MP0005409_darkened_coat_color1.12611033
98MP0003172_abnormal_lysosome_physiology1.09900291
99MP0010030_abnormal_orbit_morphology1.09007743
100MP0001765_abnormal_ion_homeostasis1.07931988
101MP0005666_abnormal_adipose_tissue1.06039581
102MP0002078_abnormal_glucose_homeostasis1.05132905
103MP0002163_abnormal_gland_morphology1.03871318
104MP0005535_abnormal_body_temperature0.98609001
105MP0002069_abnormal_eating/drinking_beha0.97492125
106MP0009672_abnormal_birth_weight0.97088931
107MP0005375_adipose_tissue_phenotype0.96853952
108MP0004233_abnormal_muscle_weight0.95830994
109MP0005670_abnormal_white_adipose0.95392013
110MP0002229_neurodegeneration0.95138386
111MP0005551_abnormal_eye_electrophysiolog0.93461182
112MP0002971_abnormal_brown_adipose0.93412138
113MP0005266_abnormal_metabolism0.91003248
114MP0001299_abnormal_eye_distance/0.90542063
115MP0001529_abnormal_vocalization0.90531678
116MP0001986_abnormal_taste_sensitivity0.88602620
117MP0004142_abnormal_muscle_tone0.87503051
118MP0003634_abnormal_glial_cell0.86676035
119MP0003656_abnormal_erythrocyte_physiolo0.86021501
120MP0004272_abnormal_basement_membrane0.85427113
121MP0002152_abnormal_brain_morphology0.84797449
122MP0004085_abnormal_heartbeat0.84664924
123MP0003137_abnormal_impulse_conducting0.84196594
124MP0003631_nervous_system_phenotype0.82302245
125MP0003959_abnormal_lean_body0.81388965
126MP0004134_abnormal_chest_morphology0.81208206
127MP0000266_abnormal_heart_morphology0.79386690
128MP0000747_muscle_weakness0.76284324
129MP0003953_abnormal_hormone_level0.75959102
130MP0001348_abnormal_lacrimal_gland0.75495974
131MP0004147_increased_porphyrin_level0.74934741
132MP0009250_abnormal_appendicular_skeleto0.73876967
133MP0000569_abnormal_digit_pigmentation0.72988698
134MP0003045_fibrosis0.72858782
135MP0004215_abnormal_myocardial_fiber0.72465640
136MP0001905_abnormal_dopamine_level0.72416398
137MP0006292_abnormal_olfactory_placode0.71783291
138MP0001849_ear_inflammation0.71659916
139MP0001188_hyperpigmentation0.71642302
140MP0005253_abnormal_eye_physiology0.70713577
141MP0001485_abnormal_pinna_reflex0.70186170
142MP0009703_decreased_birth_body0.69807722
143MP0003121_genomic_imprinting0.68641564
144MP0002090_abnormal_vision0.68397832
145MP0002114_abnormal_axial_skeleton0.67517481
146MP0002896_abnormal_bone_mineralization0.67229047
147MP0002751_abnormal_autonomic_nervous0.66994815
148MP0005084_abnormal_gallbladder_morpholo0.66495072
149MP0000462_abnormal_digestive_system0.66313122
150MP0003385_abnormal_body_wall0.65914216
151MP0008438_abnormal_cutaneous_collagen0.65461195
152MP0002249_abnormal_larynx_morphology0.61886561
153MP0004197_abnormal_fetal_growth/weight/0.61385202
154MP0000428_abnormal_craniofacial_morphol0.61078000
155MP0003948_abnormal_gas_homeostasis0.59553191
156MP0008775_abnormal_heart_ventricle0.57815057
157MP0008770_decreased_survivor_rate0.56473760
158MP0000534_abnormal_ureter_morphology0.56024195
159MP0005248_abnormal_Harderian_gland0.55381516
160MP0006036_abnormal_mitochondrial_physio0.55278253
161MP0003828_pulmonary_edema0.55107046
162MP0005083_abnormal_biliary_tract0.54562958
163MP0002081_perinatal_lethality0.51800955
164MP0002128_abnormal_blood_circulation0.51468660
165MP0000762_abnormal_tongue_morphology0.51145616
166MP0001346_abnormal_lacrimal_gland0.50768400
167MP0001943_abnormal_respiration0.48977534
168MP0010234_abnormal_vibrissa_follicle0.48597303
169MP0005187_abnormal_penis_morphology0.47018590
170MP0002089_abnormal_postnatal_growth/wei0.45808318
171MP0003935_abnormal_craniofacial_develop0.45680955
172MP0003091_abnormal_cell_migration0.43191920
173MP0002697_abnormal_eye_size0.41916077

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.95838532
2Nemaline bodies (HP:0003798)8.87487787
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.84400674
4Type 1 muscle fiber predominance (HP:0003803)7.11976273
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.88881814
6Exercise-induced muscle cramps (HP:0003710)5.60498206
7Muscle hypertrophy of the lower extremities (HP:0008968)5.54045953
8Calf muscle hypertrophy (HP:0008981)5.37962502
9Myopathic facies (HP:0002058)5.11642660
10EMG: myopathic abnormalities (HP:0003458)4.93503147
11Focal motor seizures (HP:0011153)4.88266313
12Centrally nucleated skeletal muscle fibers (HP:0003687)4.72060108
13Hyporeflexia of lower limbs (HP:0002600)4.67193037
14Abnormality of the calf musculature (HP:0001430)4.50723438
15Difficulty running (HP:0009046)4.44543923
16Distal arthrogryposis (HP:0005684)4.39212998
17Visual hallucinations (HP:0002367)4.37597332
18Increased connective tissue (HP:0009025)4.28941881
19Muscle fiber splitting (HP:0003555)4.25436042
20Abnormality of skeletal muscle fiber size (HP:0012084)4.14355474
21Myokymia (HP:0002411)4.05393096
22Abnormality of calcium-phosphate metabolism (HP:0100530)4.05343912
23Myoglobinuria (HP:0002913)4.02916733
24Rimmed vacuoles (HP:0003805)3.93086679
25Increased variability in muscle fiber diameter (HP:0003557)3.85997136
26Neck muscle weakness (HP:0000467)3.82223213
27Round ear (HP:0100830)3.80158698
28Rhabdomyolysis (HP:0003201)3.78059488
29Hyperinsulinemic hypoglycemia (HP:0000825)3.77624445
30Agitation (HP:0000713)3.72387115
31Focal seizures (HP:0007359)3.68603426
32Abnormality of the left ventricular outflow tract (HP:0011103)3.63018354
33Subaortic stenosis (HP:0001682)3.63018354
34Frequent falls (HP:0002359)3.49791593
35Distal lower limb muscle weakness (HP:0009053)3.49476858
36Pheochromocytoma (HP:0002666)3.39297764
37Epileptic encephalopathy (HP:0200134)3.38051456
38Ulnar deviation of the wrist (HP:0003049)3.37493373
39Atonic seizures (HP:0010819)3.29243790
40Papilledema (HP:0001085)3.23410564
41Hypoglycemic seizures (HP:0002173)3.21506559
42Symptomatic seizures (HP:0011145)3.14629226
43Sudden death (HP:0001699)3.10429951
44Distal lower limb amyotrophy (HP:0008944)3.08455233
45Supranuclear gaze palsy (HP:0000605)3.08358849
46Depression (HP:0000716)3.04946698
47Areflexia of lower limbs (HP:0002522)3.02120500
48Progressive cerebellar ataxia (HP:0002073)2.99289943
49Anxiety (HP:0000739)2.95683748
50Neuroendocrine neoplasm (HP:0100634)2.91292672
51Mildly elevated creatine phosphokinase (HP:0008180)2.90540243
52Absence seizures (HP:0002121)2.89857428
53Spinal rigidity (HP:0003306)2.89747091
54Difficulty climbing stairs (HP:0003551)2.89613589
55EMG: neuropathic changes (HP:0003445)2.88134373
56Calcaneovalgus deformity (HP:0001848)2.85687028
57Febrile seizures (HP:0002373)2.85295926
58Increased circulating renin level (HP:0000848)2.84959741
59Generalized tonic-clonic seizures (HP:0002069)2.81479537
60Myotonia (HP:0002486)2.79787475
61Ankle clonus (HP:0011448)2.78896195
62EEG with generalized epileptiform discharges (HP:0011198)2.75811705
63Epileptiform EEG discharges (HP:0011182)2.72774587
64Hypsarrhythmia (HP:0002521)2.69295611
65Action tremor (HP:0002345)2.67663757
66Muscle stiffness (HP:0003552)2.66105199
67Lower limb amyotrophy (HP:0007210)2.65276461
68Hyperparathyroidism (HP:0000843)2.65058538
69Generalized muscle weakness (HP:0003324)2.63233346
70Hypercortisolism (HP:0001578)2.63193401
71Hemiparesis (HP:0001269)2.62098019
72Scapular winging (HP:0003691)2.61713873
73Malignant hyperthermia (HP:0002047)2.60283842
74Bulbar palsy (HP:0001283)2.60035288
75Large for gestational age (HP:0001520)2.59933218
76Asymmetric septal hypertrophy (HP:0001670)2.59061267
77Retinal atrophy (HP:0001105)2.58834186
78Dialeptic seizures (HP:0011146)2.58427849
79Ketoacidosis (HP:0001993)2.53214788
80Hyperglycemia (HP:0003074)2.51767472
81Absent phalangeal crease (HP:0006109)2.43407962
82Deformed tarsal bones (HP:0008119)2.41888217
83Limb-girdle muscle atrophy (HP:0003797)2.41660580
84Muscular dystrophy (HP:0003560)2.40285437
85Broad-based gait (HP:0002136)2.39104826
86Slender build (HP:0001533)2.38396092
87Menstrual irregularities (HP:0000858)2.35633950
88Prolonged QT interval (HP:0001657)2.34939022
89Truncal ataxia (HP:0002078)2.34190241
90Blue irides (HP:0000635)2.32835341
91Ventricular tachycardia (HP:0004756)2.32607307
92Ventricular fibrillation (HP:0001663)2.32591620
93Pancreatic islet-cell hyperplasia (HP:0004510)2.26776179
94Limb dystonia (HP:0002451)2.26262329
95Hypokalemia (HP:0002900)2.24450070
96Dilated cardiomyopathy (HP:0001644)2.22609287
97Foot dorsiflexor weakness (HP:0009027)2.21451363
98Abnormality of the foot musculature (HP:0001436)2.21100185
99Insulin-resistant diabetes mellitus (HP:0000831)2.20458066
100Proximal amyotrophy (HP:0007126)2.19819470
101Macroorchidism (HP:0000053)2.19748828
102Decreased circulating renin level (HP:0003351)2.19153911
103Abnormal eating behavior (HP:0100738)2.18863516
104Abnormality of endocrine pancreas physiology (HP:0012093)2.18676536
105Abnormality of the pancreatic islet cells (HP:0006476)2.18676536
106Abnormality of renin-angiotensin system (HP:0000847)2.16769551
107Poor eye contact (HP:0000817)2.16616827
108Neurofibrillary tangles (HP:0002185)2.15786930
109Shoulder girdle muscle weakness (HP:0003547)2.15694265
110Neoplasm of the heart (HP:0100544)2.15075350
111Hyperphosphatemia (HP:0002905)2.13041743
112Bundle branch block (HP:0011710)2.12655463
113Pelvic girdle muscle weakness (HP:0003749)2.12623641
114Abnormality of potassium homeostasis (HP:0011042)2.11688636
115Megalencephaly (HP:0001355)2.09680254
116Dysdiadochokinesis (HP:0002075)2.08598440
117Failure to thrive in infancy (HP:0001531)2.08220444
118Late onset (HP:0003584)2.07559138
119Gaze-evoked nystagmus (HP:0000640)2.07373615
120Impaired smooth pursuit (HP:0007772)2.07325057
121Postural instability (HP:0002172)2.07032949
122Abnormality of the calcaneus (HP:0008364)2.07011229
123Drooling (HP:0002307)2.06608371
124Excessive salivation (HP:0003781)2.06608371
125Progressive muscle weakness (HP:0003323)2.05341411
126Genetic anticipation (HP:0003743)2.05324020
127Abnormality of the shoulder girdle musculature (HP:0001435)2.05103614
128Hyperkalemia (HP:0002153)2.04249239
129Adrenal overactivity (HP:0002717)2.02859908
130Dysmetria (HP:0001310)2.02517955
131Hypoventilation (HP:0002791)2.02170274
132Abnormal social behavior (HP:0012433)2.01364892
133Impaired social interactions (HP:0000735)2.01364892
134Urinary bladder sphincter dysfunction (HP:0002839)2.00819042
135Abnormal EKG (HP:0003115)1.99278054
136Abnormal finger flexion creases (HP:0006143)1.99198505
137Exercise-induced myalgia (HP:0003738)1.97721095
138Lipoatrophy (HP:0100578)1.96166846
139Dysostosis multiplex (HP:0000943)1.95313482
140Postural tremor (HP:0002174)1.95119498
141Psychosis (HP:0000709)1.95001832
142Abnormality of the musculature of the pelvis (HP:0001469)1.94716018
143Abnormality of the hip-girdle musculature (HP:0001445)1.94716018
144Hyperventilation (HP:0002883)1.93868198
145Waddling gait (HP:0002515)1.93486181
146Limb-girdle muscle weakness (HP:0003325)1.92822823
147Spastic gait (HP:0002064)1.90720547
148Cerebral inclusion bodies (HP:0100314)1.90010436
149Metabolic alkalosis (HP:0200114)1.89966694
150Impaired vibration sensation in the lower limbs (HP:0002166)1.89530077
151Restlessness (HP:0000711)1.89068008
152Fatigable weakness (HP:0003473)1.88484524
153Abnormality of the neuromuscular junction (HP:0003398)1.88484524
154Amblyopia (HP:0000646)1.88209862
155Achilles tendon contracture (HP:0001771)1.86914070
156Hip contracture (HP:0003273)1.86570864
157Gowers sign (HP:0003391)1.86415553
158Hyperacusis (HP:0010780)1.85987003
159Progressive inability to walk (HP:0002505)1.85130550
160Hypoglycemic coma (HP:0001325)1.81359065
161Torticollis (HP:0000473)1.79976714
162Type II lissencephaly (HP:0007260)1.79674708
163Fetal akinesia sequence (HP:0001989)1.78917092
164Long clavicles (HP:0000890)1.78640415
165Bradykinesia (HP:0002067)1.77855374
166Neoplasm of the peripheral nervous system (HP:0100007)1.77628557
167Mucopolysacchariduria (HP:0008155)1.74789687
168Urinary glycosaminoglycan excretion (HP:0003541)1.74789687
169Weak cry (HP:0001612)1.74569624
170Hemiplegia (HP:0002301)1.74247099
171Heart block (HP:0012722)1.74082911
172Abnormal drinking behavior (HP:0030082)1.73908946
173Polydipsia (HP:0001959)1.73908946
174Abnormal atrioventricular conduction (HP:0005150)1.73733683
175Diaphragmatic weakness (HP:0009113)1.72098928
176Hypomagnesemia (HP:0002917)1.71773082
177Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68693020
178Back pain (HP:0003418)1.66573724
179Dysmetric saccades (HP:0000641)1.66033479
180Abnormality of the Achilles tendon (HP:0005109)1.64960715
181Nonprogressive disorder (HP:0003680)1.64135584
182Steppage gait (HP:0003376)1.63513153
183Respiratory insufficiency due to muscle weakness (HP:0002747)1.53729530
184Metatarsus adductus (HP:0001840)1.53687283
185Abnormality of the ischium (HP:0003174)1.52309522
186Limited hip movement (HP:0008800)1.48995087
187Short palpebral fissure (HP:0012745)1.48165356
188Obstructive sleep apnea (HP:0002870)1.48093995
189Wrist flexion contracture (HP:0001239)1.45596843
190Adducted thumb (HP:0001181)1.43814644
191Hypoplastic ischia (HP:0003175)1.42672542
192Ventricular arrhythmia (HP:0004308)1.41648029
193Stridor (HP:0010307)1.40312602
194Ragged-red muscle fibers (HP:0003200)1.39427133
195Ulnar deviation of finger (HP:0009465)1.38066985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.19355701
2WNK34.17496956
3NTRK33.99245332
4MAPK153.09107172
5MAP3K92.93222049
6PRKD32.63342491
7MARK12.59361636
8INSRR2.53873076
9ICK2.34966601
10EPHA42.25713073
11WNK42.24489179
12UHMK12.19831087
13SIK12.12892934
14MAP3K42.07465818
15EEF2K2.05832113
16NTRK11.97653232
17TESK21.93574233
18PAK61.91682123
19MAP3K21.87290551
20DAPK21.84463245
21MINK11.82364346
22MAP2K71.72364574
23MAP2K31.71532403
24KSR21.69847032
25MAPK121.67708620
26LATS21.67680855
27NTRK21.61588415
28CAMKK11.54606075
29PHKG21.48133093
30PHKG11.48133093
31HIPK21.45892240
32CASK1.42577749
33WNK11.41550690
34CAMKK21.39830268
35CDK51.35926395
36TNIK1.34039398
37MAP3K11.33795338
38CDK121.33667460
39PAK31.30899718
40MAP2K41.26215676
41EPHA31.22150373
42STK381.21375946
43PRKCH1.19930414
44SGK2231.15121713
45SGK4941.15121713
46MAPK131.14909191
47GRK51.12766921
48MAP3K101.11891883
49CDC42BPA1.11580837
50MTOR1.05886470
51PIK3CG0.99428954
52MAP3K120.97091965
53KSR10.96855430
54ARAF0.96613100
55PNCK0.94211877
56PRKCG0.94134422
57TAOK30.91668429
58DAPK10.91110606
59RET0.90411578
60SGK20.86495983
61OXSR10.86406181
62PRKAA20.85490565
63TAOK10.84001897
64CDK190.83977638
65TRPM70.82715810
66SIK20.82689665
67SMG10.81651652
68MARK20.81230051
69CAMK2A0.80208488
70MAP3K130.78988005
71PINK10.78954385
72PRPF4B0.78811087
73STK110.77329609
74SGK10.77213766
75PKN20.76850263
76AKT20.75876345
77SGK30.75727417
78CAMK10.74604263
79PRKD20.74195947
80CAMK1G0.73444236
81FES0.72407823
82CAMK2D0.71919392
83FGFR40.71858619
84FER0.71364436
85DMPK0.71052109
86RIPK10.68537258
87LATS10.68276245
88MUSK0.67894802
89CAMK2B0.67772255
90PRKCE0.67323068
91CAMK1D0.67205297
92SCYL20.66449293
93PLK20.65926116
94DYRK1A0.65014174
95FRK0.60721274
96CCNB10.60544161
97ALK0.57311353
98PDGFRA0.57144671
99RIPK40.56982074
100MAPKAPK30.56798852
101MAPK40.55155176
102MAP2K10.54443617
103RPS6KL10.51688848
104RPS6KC10.51688848
105CSNK1G20.51669256
106NEK60.51494822
107RPS6KA30.51312617
108CDK140.51289640
109LMTK20.50770593
110RPS6KB10.50624185
111PTK20.50594750
112BRD40.48589721
113TYRO30.48404818
114MAP3K60.47057014
115PDPK10.46544792
116CDK180.46432232
117TAOK20.46329739
118CDK150.46238293
119FGFR30.46198531
120EPHB10.45817478
121OBSCN0.45268137
122MAPK110.45013542
123BCR0.44663139
124PASK0.42657290
125AKT30.42368694
126PRKAA10.41321242
127MAPK100.40969836
128RPS6KA20.40649523
129DYRK1B0.40224677
130CAMK2G0.40178242
131CAMK40.40039489
132MAP3K70.39692162
133PDK10.39497694
134TRIB30.38448154
135CDK11A0.37845541
136RPS6KA10.36903814
137BRAF0.36315853
138PKN10.35476317
139MARK30.34682761
140ROCK10.34548471
141MAPK70.34174323
142RPS6KA60.33195986
143RPS6KB20.33086826
144IRAK20.31299223
145STK38L0.31114851
146PRKG10.26111007
147PDGFRB0.24291983
148PIK3CA0.22923918
149GSK3B0.21629320
150PTK60.21330665
151NEK90.20676142

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.93143481
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.90835994
3Synaptic vesicle cycle_Homo sapiens_hsa047212.81904506
4Nicotine addiction_Homo sapiens_hsa050332.50642781
5GABAergic synapse_Homo sapiens_hsa047272.47388520
6Circadian entrainment_Homo sapiens_hsa047132.33408048
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.32868074
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.18386720
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.14848486
10Morphine addiction_Homo sapiens_hsa050322.12625082
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12483339
12Amphetamine addiction_Homo sapiens_hsa050312.12358685
13Long-term potentiation_Homo sapiens_hsa047202.06177420
14Olfactory transduction_Homo sapiens_hsa047402.05069956
15Glutamatergic synapse_Homo sapiens_hsa047242.04956488
16Type II diabetes mellitus_Homo sapiens_hsa049301.91827348
17Dopaminergic synapse_Homo sapiens_hsa047281.90099903
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84591017
19Cocaine addiction_Homo sapiens_hsa050301.84367667
20Cholinergic synapse_Homo sapiens_hsa047251.76186348
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74105130
22AMPK signaling pathway_Homo sapiens_hsa041521.73128588
23Gastric acid secretion_Homo sapiens_hsa049711.72841736
24Taste transduction_Homo sapiens_hsa047421.69329705
25Salivary secretion_Homo sapiens_hsa049701.68021687
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57841485
27Renin secretion_Homo sapiens_hsa049241.54687900
28Serotonergic synapse_Homo sapiens_hsa047261.54401278
29Type I diabetes mellitus_Homo sapiens_hsa049401.53085749
30Long-term depression_Homo sapiens_hsa047301.42511021
31Pentose phosphate pathway_Homo sapiens_hsa000301.42293870
32Vibrio cholerae infection_Homo sapiens_hsa051101.38818320
33Oxytocin signaling pathway_Homo sapiens_hsa049211.37032363
34Collecting duct acid secretion_Homo sapiens_hsa049661.34540518
35Arginine biosynthesis_Homo sapiens_hsa002201.30335761
36GnRH signaling pathway_Homo sapiens_hsa049121.25603200
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.24965872
38Calcium signaling pathway_Homo sapiens_hsa040201.23607427
39Chronic myeloid leukemia_Homo sapiens_hsa052201.22587253
40cAMP signaling pathway_Homo sapiens_hsa040241.20093193
41Pancreatic secretion_Homo sapiens_hsa049721.17661320
42Focal adhesion_Homo sapiens_hsa045101.17108214
43Carbon metabolism_Homo sapiens_hsa012001.15395390
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14758150
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.14619240
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14545186
47Estrogen signaling pathway_Homo sapiens_hsa049151.12989922
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11127891
49Non-small cell lung cancer_Homo sapiens_hsa052231.10744045
50Gap junction_Homo sapiens_hsa045401.10451159
51Notch signaling pathway_Homo sapiens_hsa043301.06410907
52Lysine degradation_Homo sapiens_hsa003101.05885776
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04599523
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03386151
55FoxO signaling pathway_Homo sapiens_hsa040681.02119557
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01638519
57Fructose and mannose metabolism_Homo sapiens_hsa000511.00866371
58Vascular smooth muscle contraction_Homo sapiens_hsa042701.00791829
59Cardiac muscle contraction_Homo sapiens_hsa042600.99035405
60Thyroid hormone synthesis_Homo sapiens_hsa049180.98735484
61Dilated cardiomyopathy_Homo sapiens_hsa054140.97571407
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96580823
63Melanogenesis_Homo sapiens_hsa049160.95897201
64Circadian rhythm_Homo sapiens_hsa047100.95421208
65VEGF signaling pathway_Homo sapiens_hsa043700.94456958
66Thyroid cancer_Homo sapiens_hsa052160.94224150
67Adherens junction_Homo sapiens_hsa045200.93551206
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92641047
69Tight junction_Homo sapiens_hsa045300.90695466
70Glucagon signaling pathway_Homo sapiens_hsa049220.89956844
71Dorso-ventral axis formation_Homo sapiens_hsa043200.89387717
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89068430
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88798307
74Phototransduction_Homo sapiens_hsa047440.86438856
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82941874
76Glioma_Homo sapiens_hsa052140.82665481
77Arginine and proline metabolism_Homo sapiens_hsa003300.81031348
78ErbB signaling pathway_Homo sapiens_hsa040120.80516312
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80427175
80Acute myeloid leukemia_Homo sapiens_hsa052210.80323070
81Axon guidance_Homo sapiens_hsa043600.76068764
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75182402
83Biosynthesis of amino acids_Homo sapiens_hsa012300.74298912
84Pancreatic cancer_Homo sapiens_hsa052120.71762728
85Hippo signaling pathway_Homo sapiens_hsa043900.69829865
86ECM-receptor interaction_Homo sapiens_hsa045120.69294301
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.68248250
88Colorectal cancer_Homo sapiens_hsa052100.67804476
89Prostate cancer_Homo sapiens_hsa052150.67640100
90Proteoglycans in cancer_Homo sapiens_hsa052050.66527474
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66194281
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65430988
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64230544
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63469131
95Insulin signaling pathway_Homo sapiens_hsa049100.61099477
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60965367
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60742299
98MAPK signaling pathway_Homo sapiens_hsa040100.60689383
99MicroRNAs in cancer_Homo sapiens_hsa052060.60670898
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.60615202
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60013538
102Lysosome_Homo sapiens_hsa041420.59734091
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58676382
104Basal cell carcinoma_Homo sapiens_hsa052170.58563708
105Inositol phosphate metabolism_Homo sapiens_hsa005620.57800050
106Prion diseases_Homo sapiens_hsa050200.57483770
107Galactose metabolism_Homo sapiens_hsa000520.57429358
108Nitrogen metabolism_Homo sapiens_hsa009100.57216917
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56722191
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56669399
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55611956
112Bladder cancer_Homo sapiens_hsa052190.54643604
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54513463
114HIF-1 signaling pathway_Homo sapiens_hsa040660.53825086
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53493860
116Protein export_Homo sapiens_hsa030600.52684818
117Ovarian steroidogenesis_Homo sapiens_hsa049130.51764670
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51458068
119Small cell lung cancer_Homo sapiens_hsa052220.51329204
120Renal cell carcinoma_Homo sapiens_hsa052110.50070837
121Ras signaling pathway_Homo sapiens_hsa040140.49853165
122Hedgehog signaling pathway_Homo sapiens_hsa043400.49836068
123Platelet activation_Homo sapiens_hsa046110.49301869
124Choline metabolism in cancer_Homo sapiens_hsa052310.49300836
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48301804
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47848234
127Endocytosis_Homo sapiens_hsa041440.47261200
128Melanoma_Homo sapiens_hsa052180.47117536
129Alcoholism_Homo sapiens_hsa050340.46501579
130Prolactin signaling pathway_Homo sapiens_hsa049170.46260008
131mTOR signaling pathway_Homo sapiens_hsa041500.44234022
132Endometrial cancer_Homo sapiens_hsa052130.44225235
133Wnt signaling pathway_Homo sapiens_hsa043100.43656412
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42727131
135Bile secretion_Homo sapiens_hsa049760.38451423
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.38256729
137Oocyte meiosis_Homo sapiens_hsa041140.37871655
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37288747
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.36450055
140Sulfur metabolism_Homo sapiens_hsa009200.35455950
141Insulin resistance_Homo sapiens_hsa049310.34490127
142Alzheimers disease_Homo sapiens_hsa050100.34378014
143Rap1 signaling pathway_Homo sapiens_hsa040150.34156536
144Chemokine signaling pathway_Homo sapiens_hsa040620.33632066
145Regulation of autophagy_Homo sapiens_hsa041400.32800365

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »