GATS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)5.42171259
2synaptic vesicle maturation (GO:0016188)5.31176555
3membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.18176148
4neuronal action potential propagation (GO:0019227)4.78567745
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.46818677
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.43760606
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.38566063
8glutamate secretion (GO:0014047)4.25843691
9locomotory exploration behavior (GO:0035641)4.25777486
10axon ensheathment in central nervous system (GO:0032291)4.23503653
11central nervous system myelination (GO:0022010)4.23503653
12synaptic vesicle exocytosis (GO:0016079)4.21463426
13regulation of synaptic vesicle exocytosis (GO:2000300)4.19418327
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15500932
15vocalization behavior (GO:0071625)4.12056792
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08595103
17positive regulation of synapse maturation (GO:0090129)4.05544109
18neuron cell-cell adhesion (GO:0007158)4.00750860
19presynaptic membrane organization (GO:0097090)3.96181797
20presynaptic membrane assembly (GO:0097105)3.92700656
21cellular potassium ion homeostasis (GO:0030007)3.87746794
22cerebellar granule cell differentiation (GO:0021707)3.86120911
23protein localization to synapse (GO:0035418)3.81768423
24neuronal ion channel clustering (GO:0045161)3.80469123
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.80442445
26sarcoplasmic reticulum calcium ion transport (GO:0070296)3.79931341
27cell migration in hindbrain (GO:0021535)3.79799509
28regulation of synaptic vesicle transport (GO:1902803)3.79074501
29dendritic spine morphogenesis (GO:0060997)3.73680709
30pyrimidine nucleobase catabolic process (GO:0006208)3.70783155
31neurotransmitter secretion (GO:0007269)3.68579827
32regulation of synapse structural plasticity (GO:0051823)3.68206647
33neuromuscular synaptic transmission (GO:0007274)3.65042472
34exploration behavior (GO:0035640)3.64675447
35neurotransmitter-gated ion channel clustering (GO:0072578)3.63564525
36establishment of mitochondrion localization (GO:0051654)3.62605850
37cerebellar Purkinje cell differentiation (GO:0021702)3.60479354
38synaptic transmission, glutamatergic (GO:0035249)3.56258539
39axonal fasciculation (GO:0007413)3.55768387
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.53821976
41membrane depolarization during action potential (GO:0086010)3.53081974
42neuron recognition (GO:0008038)3.50033870
43auditory behavior (GO:0031223)3.49074472
44regulation of glutamate receptor signaling pathway (GO:1900449)3.44363511
45regulation of synapse maturation (GO:0090128)3.40887180
46regulation of neuronal synaptic plasticity (GO:0048168)3.28553307
47sodium ion export (GO:0071436)3.28475633
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26676829
49positive regulation of dendritic spine development (GO:0060999)3.24020355
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.18549643
51mitochondrion transport along microtubule (GO:0047497)3.18549643
52glutamate receptor signaling pathway (GO:0007215)3.18441548
53layer formation in cerebral cortex (GO:0021819)3.18122342
54transmission of nerve impulse (GO:0019226)3.16592293
55potassium ion homeostasis (GO:0055075)3.15352661
56neuron-neuron synaptic transmission (GO:0007270)3.13881003
57cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13417192
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08033003
59mechanosensory behavior (GO:0007638)3.06040117
60regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05631845
61potassium ion import (GO:0010107)3.04742522
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.04700578
63nucleobase catabolic process (GO:0046113)3.02829160
64cell differentiation in hindbrain (GO:0021533)3.01491559
65L-amino acid import (GO:0043092)3.00728533
66regulation of voltage-gated calcium channel activity (GO:1901385)2.98991666
67regulation of vesicle fusion (GO:0031338)2.97861041
68positive regulation of membrane potential (GO:0045838)2.96934222
69neurotransmitter transport (GO:0006836)2.96518122
70regulation of neurotransmitter levels (GO:0001505)2.95266716
71gamma-aminobutyric acid transport (GO:0015812)2.93684565
72synapse assembly (GO:0007416)2.89902510
73regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89348103
74regulation of neurotransmitter secretion (GO:0046928)2.88351184
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.88289926
76neuromuscular process controlling balance (GO:0050885)2.87220821
77membrane depolarization (GO:0051899)2.87164479
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.87084690
79regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86416999
80dendrite morphogenesis (GO:0048813)2.86137790
81response to auditory stimulus (GO:0010996)2.84188128
82synaptic vesicle endocytosis (GO:0048488)2.82091624
83behavioral response to nicotine (GO:0035095)2.81133501
84regulation of postsynaptic membrane potential (GO:0060078)2.80781522
85regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.79935826
86regulation of dendritic spine morphogenesis (GO:0061001)2.77136451
87regulation of neurotransmitter transport (GO:0051588)2.75322002
88cell communication by electrical coupling (GO:0010644)2.75191028
89adult walking behavior (GO:0007628)2.74218737
90regulation of dendritic spine development (GO:0060998)2.71479378
91regulation of membrane repolarization (GO:0060306)2.70411614
92synapse organization (GO:0050808)2.66104394
93regulation of cell communication by electrical coupling (GO:0010649)2.64821986
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.64617388
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.63242905
96cerebral cortex radially oriented cell migration (GO:0021799)2.60476462
97negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60156173
98long-term memory (GO:0007616)2.59413042
99regulation of respiratory system process (GO:0044065)2.59014005
100positive regulation of dendrite development (GO:1900006)2.57606701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22952273
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.25832811
3DROSHA_22980978_ChIP-Seq_HELA_Human2.89616460
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74391799
5REST_21632747_ChIP-Seq_MESCs_Mouse2.73124177
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58831262
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.56934740
8EZH2_27294783_Chip-Seq_ESCs_Mouse2.53720635
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51755607
10SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40907472
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37532710
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.37446784
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35397398
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35391678
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35391678
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.23994387
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22318916
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.21711718
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17027578
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16276683
21GBX2_23144817_ChIP-Seq_PC3_Human2.09525692
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.09393462
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.06903274
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02915193
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02815000
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00494665
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98625946
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84576670
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.77288997
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76602659
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67122239
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59868507
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.55858241
34RING1B_27294783_Chip-Seq_ESCs_Mouse1.53456028
35RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44331816
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43612815
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41552833
38KDM2B_26808549_Chip-Seq_K562_Human1.39709260
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39039894
40AR_21572438_ChIP-Seq_LNCaP_Human1.38376018
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35180698
42CTCF_27219007_Chip-Seq_Bcells_Human1.34240259
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33702291
44OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33428393
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30766084
46RNF2_27304074_Chip-Seq_NSC_Mouse1.28027474
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27359548
48EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25789998
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23080627
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21270158
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.18807094
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14998084
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13217734
54AR_19668381_ChIP-Seq_PC3_Human1.13021861
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12339186
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10309628
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08942336
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.08924726
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08694087
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08185553
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06332263
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05694391
63TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04623018
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04218229
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.04063079
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03938596
67SOX2_21211035_ChIP-Seq_LN229_Gbm1.01895790
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00388351
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00388351
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96978393
71SMAD4_21799915_ChIP-Seq_A2780_Human0.96837515
72CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94735895
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93189497
74* OCT4_19829295_ChIP-Seq_ESCs_Human0.92406642
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91597299
76P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90756320
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89783569
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87483982
79CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86865399
80YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86537757
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85875226
82TET1_21490601_ChIP-Seq_MESCs_Mouse0.85521937
83KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85391822
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83730736
85TCF4_23295773_ChIP-Seq_U87_Human0.83095159
86SMAD3_21741376_ChIP-Seq_ESCs_Human0.82969232
87ESR2_21235772_ChIP-Seq_MCF-7_Human0.82658976
88TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81701175
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80860458
90* STAT3_23295773_ChIP-Seq_U87_Human0.79100100
91SMAD4_21741376_ChIP-Seq_HESCs_Human0.77350118
92* SMC4_20622854_ChIP-Seq_HELA_Human0.77235789
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75968292
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.75429196
95SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75203724
96IGF1R_20145208_ChIP-Seq_DFB_Human0.75062225
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74733960
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73708416
99SMAD3_21741376_ChIP-Seq_EPCs_Human0.73260183
100MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.72880904

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.81308132
2MP0004270_analgesia3.87341650
3MP0005423_abnormal_somatic_nervous3.69322166
4MP0003880_abnormal_central_pattern3.41583959
5MP0003635_abnormal_synaptic_transmissio3.22926572
6MP0004145_abnormal_muscle_electrophysio2.80082628
7MP0002064_seizures2.66108653
8MP0002734_abnormal_mechanical_nocicepti2.63771942
9MP0002063_abnormal_learning/memory/cond2.57841430
10MP0003646_muscle_fatigue2.57352829
11MP0009745_abnormal_behavioral_response2.52316036
12MP0002272_abnormal_nervous_system2.49451581
13MP0001486_abnormal_startle_reflex2.36250876
14MP0000778_abnormal_nervous_system2.29911510
15MP0009046_muscle_twitch2.20383169
16MP0002572_abnormal_emotion/affect_behav2.17166600
17MP0003122_maternal_imprinting2.07867682
18MP0002822_catalepsy2.02847012
19MP0003879_abnormal_hair_cell2.01364884
20MP0001968_abnormal_touch/_nociception2.01261847
21MP0003787_abnormal_imprinting2.00090492
22MP0006276_abnormal_autonomic_nervous1.92489247
23MP0002735_abnormal_chemical_nociception1.92153733
24MP0008569_lethality_at_weaning1.89975438
25MP0001984_abnormal_olfaction1.79589382
26MP0001970_abnormal_pain_threshold1.77443937
27MP0004130_abnormal_muscle_cell1.76559671
28MP0000955_abnormal_spinal_cord1.75811581
29MP0002067_abnormal_sensory_capabilities1.72814908
30MP0002733_abnormal_thermal_nociception1.71501605
31MP0002557_abnormal_social/conspecific_i1.67319260
32MP0000751_myopathy1.67285178
33MP0001502_abnormal_circadian_rhythm1.65776994
34MP0004885_abnormal_endolymph1.62910691
35MP0000749_muscle_degeneration1.60839556
36MP0001501_abnormal_sleep_pattern1.58694180
37MP0002184_abnormal_innervation1.57993756
38MP0004811_abnormal_neuron_physiology1.55818814
39MP0003329_amyloid_beta_deposits1.53756886
40MP0002882_abnormal_neuron_morphology1.52422584
41MP0001440_abnormal_grooming_behavior1.51314688
42MP0003123_paternal_imprinting1.43860978
43MP0004142_abnormal_muscle_tone1.43558822
44MP0005646_abnormal_pituitary_gland1.42663542
45MP0002736_abnormal_nociception_after1.35184150
46MP0002066_abnormal_motor_capabilities/c1.35135011
47MP0002638_abnormal_pupillary_reflex1.34257289
48MP0004924_abnormal_behavior1.32828875
49MP0005386_behavior/neurological_phenoty1.32828875
50MP0003633_abnormal_nervous_system1.29875604
51MP0005645_abnormal_hypothalamus_physiol1.29074177
52MP0002909_abnormal_adrenal_gland1.26452535
53MP0003690_abnormal_glial_cell1.25261739
54MP0000747_muscle_weakness1.24518627
55MP0001485_abnormal_pinna_reflex1.23515868
56MP0009780_abnormal_chondrocyte_physiolo1.23092823
57MP0002653_abnormal_ependyma_morphology1.21969086
58MP0002152_abnormal_brain_morphology1.20916177
59MP0001529_abnormal_vocalization1.19587437
60MP0003121_genomic_imprinting1.17182997
61MP0004742_abnormal_vestibular_system1.12421444
62MP0001905_abnormal_dopamine_level1.09504409
63MP0003631_nervous_system_phenotype1.07451331
64MP0002106_abnormal_muscle_physiology1.05731791
65MP0002752_abnormal_somatic_nervous1.05356915
66MP0002229_neurodegeneration1.04999343
67MP0005551_abnormal_eye_electrophysiolog1.01596950
68MP0000920_abnormal_myelination1.01057794
69MP0001963_abnormal_hearing_physiology0.96900396
70MP0004036_abnormal_muscle_relaxation0.96826430
71MP0000631_abnormal_neuroendocrine_gland0.92898545
72MP0005369_muscle_phenotype0.92011603
73MP0000759_abnormal_skeletal_muscle0.91941669
74MP0005167_abnormal_blood-brain_barrier0.91164122
75MP0003634_abnormal_glial_cell0.90696502
76MP0004043_abnormal_pH_regulation0.88079237
77MP0005499_abnormal_olfactory_system0.83380372
78MP0005394_taste/olfaction_phenotype0.83380372
79MP0000026_abnormal_inner_ear0.81801841
80MP0003632_abnormal_nervous_system0.81688628
81MP0005620_abnormal_muscle_contractility0.80593193
82MP0004087_abnormal_muscle_fiber0.80554611
83MP0001986_abnormal_taste_sensitivity0.79375206
84MP0004133_heterotaxia0.78758706
85MP0003861_abnormal_nervous_system0.76523236
86MP0003137_abnormal_impulse_conducting0.75909873
87MP0001188_hyperpigmentation0.75038660
88MP0002332_abnormal_exercise_endurance0.74658595
89MP0001299_abnormal_eye_distance/0.74211883
90MP0003283_abnormal_digestive_organ0.73752816
91MP0002069_abnormal_eating/drinking_beha0.72586978
92MP0002269_muscular_atrophy0.71790392
93MP0008872_abnormal_physiological_respon0.66232755
94MP0005409_darkened_coat_color0.65420299
95MP0004858_abnormal_nervous_system0.65182747
96MP0004085_abnormal_heartbeat0.63854433
97MP0003938_abnormal_ear_development0.63249130
98MP0000566_synostosis0.63002311
99MP0001943_abnormal_respiration0.62709133
100MP0003136_yellow_coat_color0.58675829

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.16231329
2Focal motor seizures (HP:0011153)4.87690727
3Muscle fiber inclusion bodies (HP:0100299)4.64062342
4Nemaline bodies (HP:0003798)4.44226100
5Focal seizures (HP:0007359)4.40834528
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.38149087
7Febrile seizures (HP:0002373)3.94392489
8Epileptic encephalopathy (HP:0200134)3.64473410
9Exercise-induced myalgia (HP:0003738)3.64030559
10Type 1 muscle fiber predominance (HP:0003803)3.35378736
11Fetal akinesia sequence (HP:0001989)3.30453534
12Atonic seizures (HP:0010819)3.27324191
13Ankle clonus (HP:0011448)3.21599104
14Action tremor (HP:0002345)3.13165527
15Exercise-induced muscle cramps (HP:0003710)3.11020775
16Limb dystonia (HP:0002451)3.06356135
17Diplopia (HP:0000651)3.05893197
18Abnormality of binocular vision (HP:0011514)3.05893197
19Generalized tonic-clonic seizures (HP:0002069)3.04952064
20Progressive cerebellar ataxia (HP:0002073)3.03133252
21Muscle hypertrophy of the lower extremities (HP:0008968)2.94146634
22Supranuclear gaze palsy (HP:0000605)2.90792345
23Broad-based gait (HP:0002136)2.82944165
24Urinary bladder sphincter dysfunction (HP:0002839)2.78897646
25Abnormality of the corticospinal tract (HP:0002492)2.76950708
26Myotonia (HP:0002486)2.76740598
27Absence seizures (HP:0002121)2.75389022
28Abnormal eating behavior (HP:0100738)2.73511507
29Spastic gait (HP:0002064)2.72413262
30Obstructive sleep apnea (HP:0002870)2.70752636
31Myopathic facies (HP:0002058)2.70264737
32Dialeptic seizures (HP:0011146)2.70215500
33Calf muscle hypertrophy (HP:0008981)2.66014292
34Visual hallucinations (HP:0002367)2.64921828
35Polyphagia (HP:0002591)2.63311940
36Difficulty running (HP:0009046)2.59415504
37Hyporeflexia of lower limbs (HP:0002600)2.55290832
38Muscle fiber splitting (HP:0003555)2.53447101
39Genetic anticipation (HP:0003743)2.52873204
40Sleep apnea (HP:0010535)2.48572320
41Distal arthrogryposis (HP:0005684)2.45378966
42Hemiparesis (HP:0001269)2.43034270
43Hemiplegia (HP:0002301)2.42170813
44Neurofibrillary tangles (HP:0002185)2.41062626
45EMG: neuropathic changes (HP:0003445)2.40764316
46Postural instability (HP:0002172)2.38243748
47Akinesia (HP:0002304)2.37169473
48Frequent falls (HP:0002359)2.34926914
49Hyperventilation (HP:0002883)2.33322080
50Impaired vibration sensation in the lower limbs (HP:0002166)2.32958566
51Urinary urgency (HP:0000012)2.31175999
52Drooling (HP:0002307)2.28818065
53EMG: myopathic abnormalities (HP:0003458)2.18870184
54Bundle branch block (HP:0011710)2.17242019
55Poor eye contact (HP:0000817)2.15181541
56Torticollis (HP:0000473)2.14549410
57Papilledema (HP:0001085)2.11429302
58Polydipsia (HP:0001959)2.11312472
59Abnormal drinking behavior (HP:0030082)2.11312472
60Excessive salivation (HP:0003781)2.11119592
61Epileptiform EEG discharges (HP:0011182)2.10371255
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09771795
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.09771795
64Abnormality of the calf musculature (HP:0001430)2.07370818
65Status epilepticus (HP:0002133)2.04424958
66Impaired social interactions (HP:0000735)2.02611017
67Abnormal social behavior (HP:0012433)2.02611017
68Lower limb muscle weakness (HP:0007340)2.00330656
69Agitation (HP:0000713)1.99771419
70Rimmed vacuoles (HP:0003805)1.95766797
71EEG with generalized epileptiform discharges (HP:0011198)1.94646875
72Megalencephaly (HP:0001355)1.93672914
73Dysmetria (HP:0001310)1.88040453
74Round ear (HP:0100830)1.87572939
75Hypsarrhythmia (HP:0002521)1.87473383
76Subaortic stenosis (HP:0001682)1.87167305
77Abnormality of the left ventricular outflow tract (HP:0011103)1.87167305
78Peripheral hypomyelination (HP:0007182)1.86936998
79Intention tremor (HP:0002080)1.83853007
80Truncal ataxia (HP:0002078)1.82551509
81Depression (HP:0000716)1.81682240
82Amblyopia (HP:0000646)1.81630278
83Absent speech (HP:0001344)1.81620091
84Prolonged QT interval (HP:0001657)1.80644147
85Gait imbalance (HP:0002141)1.80414382
86Cerebral inclusion bodies (HP:0100314)1.80310499
87Morphological abnormality of the pyramidal tract (HP:0002062)1.79423353
88Nonprogressive disorder (HP:0003680)1.77466493
89Anxiety (HP:0000739)1.73723578
90Dysdiadochokinesis (HP:0002075)1.73330483
91Hyperkalemia (HP:0002153)1.71734439
92Foot dorsiflexor weakness (HP:0009027)1.71168828
93Abnormality of the foot musculature (HP:0001436)1.70805514
94Abnormal respiratory motile cilium morphology (HP:0005938)1.70558773
95Abnormal respiratory epithelium morphology (HP:0012253)1.70558773
96Weak cry (HP:0001612)1.68180910
97Ulnar deviation of the wrist (HP:0003049)1.66409338
98Sudden death (HP:0001699)1.66389771
99Abnormality of the lower motor neuron (HP:0002366)1.64882902
100Hypomagnesemia (HP:0002917)1.63194353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.84117780
2NTRK33.37669983
3OBSCN3.33557636
4PHKG23.24825762
5PHKG13.24825762
6CASK3.10284810
7EPHA42.87197174
8NTRK22.85454464
9MAP3K92.57456551
10SIK22.20634220
11PAK62.06766158
12DAPK21.99762689
13PINK11.98421006
14UHMK11.84707686
15MAPK131.80106719
16CAMKK11.77896176
17MINK11.71210440
18SGK2231.64602240
19SGK4941.64602240
20TYRO31.57232434
21NTRK11.49684404
22SGK21.47076734
23MARK21.42876907
24PRKD31.31422722
25MAP2K41.30778236
26CAMK11.28394122
27CDK51.27569770
28MAPK121.25230675
29PKN11.24583130
30FGFR21.23549405
31MAP3K41.15057720
32ICK1.14342949
33SGK31.11803555
34PAK31.09855145
35PRKCH1.09478706
36MAPK151.07643956
37PRKCG1.06670507
38TRIB31.03679316
39RIPK11.00939073
40DYRK1A0.99950943
41DYRK20.98591357
42CAMK40.97582762
43MAP2K70.96898206
44CAMK2B0.95620042
45STK110.93700386
46TTN0.92440698
47SGK10.87749157
48DYRK1B0.86944304
49KSR10.86441587
50CAMK2A0.86139438
51MAP3K70.86133485
52CAMK2G0.82753174
53TNIK0.77518016
54KSR20.75590959
55ARAF0.74702173
56PRKCZ0.70578012
57PNCK0.66648027
58CAMK1G0.64979478
59MAP3K110.63934128
60CAMKK20.63798507
61TNK20.60439652
62PRKAA10.59843029
63CDK150.59206487
64MAPK100.59135657
65RPS6KA20.58867494
66CDK11A0.58315805
67RPS6KA30.57875538
68LIMK10.55238866
69CDK180.54920897
70CDK190.54391880
71ERBB20.53580523
72CDK140.50674128
73PRKG10.50635532
74CAMK2D0.50362889
75INSRR0.48729632
76WNK10.47677568
77CAMK1D0.47202055
78DMPK0.46409394
79PLK20.46401071
80CSNK1G20.45379673
81PDK10.44401284
82STK380.44326580
83WNK40.43771828
84PIK3CA0.42232485
85PRKACA0.41837035
86NEK60.41788317
87ROCK20.41643417
88BRAF0.38647019
89GRK50.37326747
90RET0.37260504
91ROCK10.36149660
92PDPK10.35795170
93MAPK80.34847665
94RPS6KB10.33807433
95WNK30.32725584
96EPHA30.32445298
97ALK0.31850684
98CSNK1A10.29694409
99FYN0.29414765
100CSNK1D0.29411487

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.49759472
2Synaptic vesicle cycle_Homo sapiens_hsa047212.74700094
3Circadian entrainment_Homo sapiens_hsa047132.56462292
4Glutamatergic synapse_Homo sapiens_hsa047242.39855946
5GABAergic synapse_Homo sapiens_hsa047272.35285763
6Insulin secretion_Homo sapiens_hsa049112.26463975
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25408017
8Morphine addiction_Homo sapiens_hsa050322.23404744
9Amphetamine addiction_Homo sapiens_hsa050312.21179439
10Long-term potentiation_Homo sapiens_hsa047202.19798680
11Dopaminergic synapse_Homo sapiens_hsa047282.06476744
12Cocaine addiction_Homo sapiens_hsa050301.99618316
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.95610832
14Cholinergic synapse_Homo sapiens_hsa047251.88459947
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86385790
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80731575
17Gastric acid secretion_Homo sapiens_hsa049711.80465518
18Cardiac muscle contraction_Homo sapiens_hsa042601.77715886
19Oxytocin signaling pathway_Homo sapiens_hsa049211.75770106
20Salivary secretion_Homo sapiens_hsa049701.71575306
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67403073
22Calcium signaling pathway_Homo sapiens_hsa040201.55235784
23Long-term depression_Homo sapiens_hsa047301.52352406
24Axon guidance_Homo sapiens_hsa043601.41299815
25cAMP signaling pathway_Homo sapiens_hsa040241.40300656
26Dilated cardiomyopathy_Homo sapiens_hsa054141.38641646
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28808453
28Phototransduction_Homo sapiens_hsa047441.24923352
29Renin secretion_Homo sapiens_hsa049241.24718125
30Taste transduction_Homo sapiens_hsa047421.23265953
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22110933
32Serotonergic synapse_Homo sapiens_hsa047261.20101287
33GnRH signaling pathway_Homo sapiens_hsa049121.19350994
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07802793
35Estrogen signaling pathway_Homo sapiens_hsa049151.06927576
36Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06668997
37Circadian rhythm_Homo sapiens_hsa047101.06117379
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06109753
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03062815
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02132827
41Olfactory transduction_Homo sapiens_hsa047401.00528817
42ErbB signaling pathway_Homo sapiens_hsa040120.99616691
43Gap junction_Homo sapiens_hsa045400.98592413
44Glioma_Homo sapiens_hsa052140.98358812
45Melanogenesis_Homo sapiens_hsa049160.97959019
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97837861
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.97644579
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96141676
49Glucagon signaling pathway_Homo sapiens_hsa049220.94056838
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.92376612
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.92100873
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91993023
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91647218
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91102905
55Type II diabetes mellitus_Homo sapiens_hsa049300.90814785
56MAPK signaling pathway_Homo sapiens_hsa040100.90387225
57Bile secretion_Homo sapiens_hsa049760.83250751
58Dorso-ventral axis formation_Homo sapiens_hsa043200.82802288
59Choline metabolism in cancer_Homo sapiens_hsa052310.81783406
60Pancreatic secretion_Homo sapiens_hsa049720.81140915
61Insulin signaling pathway_Homo sapiens_hsa049100.81032156
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78937615
63VEGF signaling pathway_Homo sapiens_hsa043700.77242463
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76959566
65Ras signaling pathway_Homo sapiens_hsa040140.73782670
66Arginine and proline metabolism_Homo sapiens_hsa003300.71559322
67Thyroid hormone synthesis_Homo sapiens_hsa049180.70810942
68Tight junction_Homo sapiens_hsa045300.69513136
69Histidine metabolism_Homo sapiens_hsa003400.69273314
70AMPK signaling pathway_Homo sapiens_hsa041520.67538856
71Endometrial cancer_Homo sapiens_hsa052130.66085783
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63497178
73Collecting duct acid secretion_Homo sapiens_hsa049660.61997017
74Rap1 signaling pathway_Homo sapiens_hsa040150.61652937
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59705506
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57893519
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53879830
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53348590
79Ovarian steroidogenesis_Homo sapiens_hsa049130.52308535
80Nitrogen metabolism_Homo sapiens_hsa009100.50649985
81Notch signaling pathway_Homo sapiens_hsa043300.49604728
82beta-Alanine metabolism_Homo sapiens_hsa004100.49417781
83mTOR signaling pathway_Homo sapiens_hsa041500.49059719
84Wnt signaling pathway_Homo sapiens_hsa043100.48766857
85Inositol phosphate metabolism_Homo sapiens_hsa005620.47664782
86Hippo signaling pathway_Homo sapiens_hsa043900.47416597
87Arginine biosynthesis_Homo sapiens_hsa002200.46723507
88Hedgehog signaling pathway_Homo sapiens_hsa043400.46084162
89Alzheimers disease_Homo sapiens_hsa050100.45435733
90Alcoholism_Homo sapiens_hsa050340.45354452
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44567183
92Renal cell carcinoma_Homo sapiens_hsa052110.43389454
93ABC transporters_Homo sapiens_hsa020100.39095359
94FoxO signaling pathway_Homo sapiens_hsa040680.36715967
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35587797
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.35424807
97Endocytosis_Homo sapiens_hsa041440.35294969
98Oocyte meiosis_Homo sapiens_hsa041140.34048195
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34038495
100Basal cell carcinoma_Homo sapiens_hsa052170.32860732

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »