GATA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucocorticoid biosynthetic process (GO:0006704)6.75348506
2cardiac myofibril assembly (GO:0055003)5.53990108
3sarcomere organization (GO:0045214)5.33700514
4* regulation of cardioblast differentiation (GO:0051890)5.32837400
5bundle of His cell to Purkinje myocyte communication (GO:0086069)5.20910030
6cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.00797899
7glucocorticoid metabolic process (GO:0008211)4.80805353
8cardiac muscle cell development (GO:0055013)4.74469530
9ventricular cardiac muscle cell action potential (GO:0086005)4.64334591
10negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.48845109
11cardiac cell development (GO:0055006)4.43993708
12cardiac muscle tissue morphogenesis (GO:0055008)4.39036984
13myofibril assembly (GO:0030239)4.38272172
14ventricular cardiac muscle cell development (GO:0055015)4.32725668
15response to follicle-stimulating hormone (GO:0032354)4.18659448
16muscle filament sliding (GO:0030049)4.09072505
17actin-myosin filament sliding (GO:0033275)4.09072505
18purine nucleobase biosynthetic process (GO:0009113)4.06670435
19androgen biosynthetic process (GO:0006702)4.06317327
20cardiac right ventricle morphogenesis (GO:0003215)4.03484684
21ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.97443000
22heart trabecula formation (GO:0060347)3.96985917
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.94379098
24muscle tissue morphogenesis (GO:0060415)3.89912783
25negative regulation of potassium ion transmembrane transport (GO:1901380)3.83677451
26tricarboxylic acid cycle (GO:0006099)3.73762732
27intestinal epithelial cell development (GO:0060576)3.73305458
28cardiac muscle contraction (GO:0060048)3.70504408
29actomyosin structure organization (GO:0031032)3.69281138
30actin-mediated cell contraction (GO:0070252)3.61905871
31atrioventricular valve morphogenesis (GO:0003181)3.61223228
32NADH metabolic process (GO:0006734)3.59391964
33nucleobase biosynthetic process (GO:0046112)3.58588013
34SMAD protein signal transduction (GO:0060395)3.56941406
35regulation of glucocorticoid metabolic process (GO:0031943)3.55986155
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47369381
37C21-steroid hormone biosynthetic process (GO:0006700)3.47333463
38sequestering of extracellular ligand from receptor (GO:0035581)3.46768112
39desmosome organization (GO:0002934)3.46214024
40negative regulation of striated muscle cell apoptotic process (GO:0010664)3.42547537
41negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.40786501
42signal transduction involved in regulation of gene expression (GO:0023019)3.39298217
43cell migration involved in gastrulation (GO:0042074)3.38705095
44regulation of retinoic acid receptor signaling pathway (GO:0048385)3.34624206
45formation of translation preinitiation complex (GO:0001731)3.33765042
46lung-associated mesenchyme development (GO:0060484)3.33102712
47ribosome assembly (GO:0042255)3.32557225
48heart contraction (GO:0060047)3.27360170
49heart process (GO:0003015)3.27360170
50adult heart development (GO:0007512)3.27245967
51atrial septum morphogenesis (GO:0060413)3.26481304
52regulation of striated muscle cell apoptotic process (GO:0010662)3.21788651
53negative regulation of hormone biosynthetic process (GO:0032353)3.18047732
54negative regulation of hormone metabolic process (GO:0032351)3.17179484
55* cardiac muscle hypertrophy (GO:0003300)3.14787683
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14129065
57ATP synthesis coupled proton transport (GO:0015986)3.14129065
58embryonic heart tube development (GO:0035050)3.12784963
59mitotic metaphase plate congression (GO:0007080)3.11986781
60regulation of steroid hormone biosynthetic process (GO:0090030)3.11960318
61anterior/posterior axis specification, embryo (GO:0008595)3.11405403
62intestinal absorption (GO:0050892)3.09206221
63very-low-density lipoprotein particle assembly (GO:0034379)3.06067014
64paraxial mesoderm development (GO:0048339)3.04429836
65labyrinthine layer development (GO:0060711)3.03416149
66* cellular response to gonadotropin stimulus (GO:0071371)3.02945009
67epithelial cell-cell adhesion (GO:0090136)3.01733555
68endocardial cushion development (GO:0003197)3.00158275
69regulation of tight junction assembly (GO:2000810)2.99277844
70adhesion of symbiont to host (GO:0044406)2.97909986
71oxidative phosphorylation (GO:0006119)2.97660375
72regulation of actin filament-based movement (GO:1903115)2.93802456
73negative regulation of activin receptor signaling pathway (GO:0032926)2.91099929
74* striated muscle hypertrophy (GO:0014897)2.90502522
75folic acid metabolic process (GO:0046655)2.90040716
76embryonic foregut morphogenesis (GO:0048617)2.89943168
77maturation of SSU-rRNA (GO:0030490)2.89043160
78cardiac muscle cell action potential involved in contraction (GO:0086002)2.87916002
79* positive regulation of cardiac muscle cell proliferation (GO:0060045)2.84173362
80trabecula formation (GO:0060343)2.82811776
81folic acid transport (GO:0015884)2.82368520
82regulation of ATP catabolic process (GO:1903289)2.79696317
83regulation of ATPase activity (GO:0043462)2.79696317
84plasma lipoprotein particle assembly (GO:0034377)2.77912824
85* positive regulation of cardiac muscle tissue development (GO:0055025)2.77581436
86cardiac muscle cell action potential (GO:0086001)2.76898146
87pericardium development (GO:0060039)2.75911047
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.75589040
89receptor guanylyl cyclase signaling pathway (GO:0007168)2.73406766
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.73125004
91progesterone metabolic process (GO:0042448)2.69945882
92regulation of G0 to G1 transition (GO:0070316)2.69933654
93endoderm formation (GO:0001706)2.69765022
94male genitalia development (GO:0030539)2.67881339
95actin filament-based movement (GO:0030048)2.66953645
96regulation of cardiac muscle cell apoptotic process (GO:0010665)2.62841655
97glomerulus development (GO:0032835)2.62370578
98cardiac chamber formation (GO:0003207)2.61883671
99histone-serine phosphorylation (GO:0035404)2.61799463
100* outflow tract septum morphogenesis (GO:0003148)2.61597566
101regulation of skeletal muscle contraction (GO:0014819)2.60687330
102regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.60250893
103blastocyst development (GO:0001824)2.58628926
104regulation of the force of heart contraction (GO:0002026)2.58528104
105cardiac septum development (GO:0003279)2.58134964
106gap junction assembly (GO:0016264)2.57222471
107peptidyl-proline hydroxylation (GO:0019511)2.57128756
108protein hydroxylation (GO:0018126)2.56680823
109* response to gonadotropin (GO:0034698)2.56339307
110regulation of systemic arterial blood pressure by hormone (GO:0001990)2.56221550
111regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.56221550
112endocrine process (GO:0050886)2.56221550
113positive regulation of SMAD protein import into nucleus (GO:0060391)2.56049539
114regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.55696978
115growth hormone secretion (GO:0030252)2.55340786
116notochord development (GO:0030903)2.55036377
117protein-lipid complex assembly (GO:0065005)2.54562227
118regulation of SMAD protein import into nucleus (GO:0060390)2.53765259
119* cardiac septum morphogenesis (GO:0060411)2.52322135
120anterior/posterior axis specification (GO:0009948)2.52307393
121embryonic digestive tract morphogenesis (GO:0048557)2.51922984
122regulation of cardiac muscle cell contraction (GO:0086004)2.51369979
123positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50747912
124galactose catabolic process (GO:0019388)2.50436183
125cellular response to antibiotic (GO:0071236)2.50182535
126regulation of sarcomere organization (GO:0060297)2.49196583
127termination of RNA polymerase I transcription (GO:0006363)2.48783447
128metaphase plate congression (GO:0051310)2.48734084
129cell communication by electrical coupling (GO:0010644)2.48711258
130ribosomal large subunit biogenesis (GO:0042273)2.48696432
131carnitine shuttle (GO:0006853)2.48095485
132plasma membrane repair (GO:0001778)2.47775467
133positive regulation of hormone biosynthetic process (GO:0046886)2.47077891
134anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.46640449
135* positive regulation of cardiac muscle tissue growth (GO:0055023)2.46551340
136interferon-gamma secretion (GO:0072643)2.45671343
137regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45601387
138endocardial cushion morphogenesis (GO:0003203)2.45416858
139* cardiac muscle adaptation (GO:0014887)2.44810357
140* cardiac muscle hypertrophy in response to stress (GO:0014898)2.44810357
141* muscle hypertrophy in response to stress (GO:0003299)2.44810357
142primitive streak formation (GO:0090009)2.44544536
143heart valve morphogenesis (GO:0003179)2.44540998
144striated muscle contraction (GO:0006941)2.44085916
145cellular response to epinephrine stimulus (GO:0071872)2.43445454
146rRNA modification (GO:0000154)2.43409071
147regulation of mitochondrial translation (GO:0070129)2.43150767
148regulation of spindle organization (GO:0090224)2.42951916
149* muscle hypertrophy (GO:0014896)2.42711718
150regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.42671771
151androgen metabolic process (GO:0008209)2.42509867
152regulation of cholesterol esterification (GO:0010872)2.42175672
153regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41763847
154regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.41712096
155* regulation of cardiac muscle tissue development (GO:0055024)2.40476027
156venous blood vessel morphogenesis (GO:0048845)2.40391296
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.40335450
158regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.39987047
159nucleotide-sugar biosynthetic process (GO:0009226)2.39491430
160regulation of cholesterol homeostasis (GO:2000188)2.38204432
161positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.37545824
162cell communication involved in cardiac conduction (GO:0086065)2.36528390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.39554032
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.34815277
3* CDX2_20551321_ChIP-Seq_CACO-2_Human3.31061521
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.10310507
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09401486
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.08363109
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04985955
8AR_21909140_ChIP-Seq_LNCAP_Human2.97736101
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77295318
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.71849515
11ZNF263_19887448_ChIP-Seq_K562_Human2.71619073
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59426173
13E2F7_22180533_ChIP-Seq_HELA_Human2.57885362
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56331212
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50160774
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.48777706
17* SMAD3_21741376_ChIP-Seq_HESCs_Human2.45140115
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.36098332
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.24830944
20* CDX2_19796622_ChIP-Seq_MESCs_Mouse2.22950711
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.18778375
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.18778375
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.18778375
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.17913242
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17194454
26* SALL4_18804426_ChIP-ChIP_XEN_Mouse2.08045387
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01749758
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00600796
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88341502
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88329114
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82454451
32TRIM28_21343339_ChIP-Seq_HEK293_Human1.81889730
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77833872
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74656364
35* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73478215
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73311168
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72835957
38* SMAD4_21741376_ChIP-Seq_HESCs_Human1.72789575
39EOMES_21245162_ChIP-Seq_HESCs_Human1.71984212
40* FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71866889
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.71185528
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70510946
43EP300_21415370_ChIP-Seq_HL-1_Mouse1.68360479
44CLOCK_20551151_ChIP-Seq_293T_Human1.64349069
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63992399
46DCP1A_22483619_ChIP-Seq_HELA_Human1.63689464
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62306813
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.61863708
49MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.61786285
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61253850
51* SOX2_20726797_ChIP-Seq_SW620_Human1.60972448
52XRN2_22483619_ChIP-Seq_HELA_Human1.59790025
53* FOXO3_23340844_ChIP-Seq_DLD1_Human1.58513877
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.57960032
55WT1_19549856_ChIP-ChIP_CCG9911_Human1.57361403
56* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.57247557
57* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54455710
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54187028
59GABP_19822575_ChIP-Seq_HepG2_Human1.53999640
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53931392
61ATF3_27146783_Chip-Seq_COLON_Human1.51710378
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.48451419
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48027509
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.47987522
65TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46617312
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46527499
67NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.46147068
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42746764
69EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.42077597
70POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41996045
71ELK1_22589737_ChIP-Seq_MCF10A_Human1.40041850
72GATA4_21415370_ChIP-Seq_HL-1_Mouse1.38603293
73VDR_23849224_ChIP-Seq_CD4+_Human1.38141635
74* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37784602
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36348511
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36153970
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.36103689
78RACK7_27058665_Chip-Seq_MCF-7_Human1.36006364
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.34984963
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34233578
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33794181
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33437858
83* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32783056
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32553560
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31961356
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31950543
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31679253
88* GATA4_25053715_ChIP-Seq_YYC3_Human1.31007459
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.29826464
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28741634
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.27874630
92* SOX17_20123909_ChIP-Seq_XEN_Mouse1.27569256
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25968315
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25869102
95TTF2_22483619_ChIP-Seq_HELA_Human1.24672686
96* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23331149
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23109520
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.23096069
99ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22372921
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21889889
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20532999
102SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19107613
103SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18934236
104GATA3_24758297_ChIP-Seq_MCF-7_Human1.17694118
105RXR_22158963_ChIP-Seq_LIVER_Mouse1.17209097
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.16412213
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15577944
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15560820
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14689996
110* EED_16625203_ChIP-ChIP_MESCs_Mouse1.14231360
111* GATA6_25053715_ChIP-Seq_YYC3_Human1.14186802
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14143595
113* FOXA2_19822575_ChIP-Seq_HepG2_Human1.13973238
114SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13816801
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13534670
116SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12099635
117* TBX20_22328084_ChIP-Seq_HEART_Mouse1.12094075
118* TBX20_22080862_ChIP-Seq_HEART_Mouse1.12094075
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12005540
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11884637
121YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11799690
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.11712329
123* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11622069
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09766657
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09766657
126TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09538834
127KDM5A_27292631_Chip-Seq_BREAST_Human1.09339023
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08952606
129ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08822192
130* CJUN_26792858_Chip-Seq_BT549_Human1.07457643
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06884006
132RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06439885
133FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05537715
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05225253
135SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04853887
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04853887
137OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03687279
138ESR1_21235772_ChIP-Seq_MCF-7_Human1.03271041
139FOXP3_21729870_ChIP-Seq_TREG_Human1.02485905
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.01325708
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01216152
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00183916
143CHD1_26751641_Chip-Seq_LNCaP_Human0.99826771
144* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99649835
145STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99589166
146* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99196764
147* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99196764
148SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99064396
149CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99044585
150TCF4_18268006_ChIP-ChIP_LS174T_Human0.98024079
151P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97962471
152LXR_22158963_ChIP-Seq_LIVER_Mouse0.97083565
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96110899
154ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95502680
155THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95490274
156UBF1/2_26484160_Chip-Seq_HMECs_Human0.94312400
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93522266
158WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93405925
159SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92751693
160ELK1_19687146_ChIP-ChIP_HELA_Human0.92074757
161* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92029278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.70359118
2MP0004084_abnormal_cardiac_muscle4.45192497
3MP0003693_abnormal_embryo_hatching2.83775741
4MP0003567_abnormal_fetal_cardiomyocyte2.79102843
5MP0003283_abnormal_digestive_organ2.76480927
6MP0004215_abnormal_myocardial_fiber2.71963057
7MP0005330_cardiomyopathy2.71050980
8MP0003123_paternal_imprinting2.53174414
9MP0000462_abnormal_digestive_system2.51249176
10MP0003890_abnormal_embryonic-extraembry2.50802992
11MP0004036_abnormal_muscle_relaxation2.48950097
12MP0002837_dystrophic_cardiac_calcinosis2.42772604
13MP0003941_abnormal_skin_development2.38074020
14MP0004272_abnormal_basement_membrane2.35099143
15MP0006138_congestive_heart_failure2.35086156
16MP0003705_abnormal_hypodermis_morpholog2.32944925
17MP0005451_abnormal_body_composition2.32794570
18MP0003828_pulmonary_edema2.32495954
19MP0004957_abnormal_blastocyst_morpholog2.32191006
20MP0002972_abnormal_cardiac_muscle2.08755520
21MP0003221_abnormal_cardiomyocyte_apopto2.07566604
22MP0000537_abnormal_urethra_morphology2.07525346
23MP0010630_abnormal_cardiac_muscle1.96751360
24MP0005385_cardiovascular_system_phenoty1.95033891
25MP0001544_abnormal_cardiovascular_syste1.95033891
26MP0008775_abnormal_heart_ventricle1.92199321
27MP0009384_cardiac_valve_regurgitation1.91357775
28MP0010368_abnormal_lymphatic_system1.84763880
29MP0000749_muscle_degeneration1.84702854
30MP0003646_muscle_fatigue1.83150102
31MP0000751_myopathy1.78304557
32MP0000750_abnormal_muscle_regeneration1.71432104
33MP0004087_abnormal_muscle_fiber1.70850444
34MP0003279_aneurysm1.63756011
35MP0003950_abnormal_plasma_membrane1.62813671
36MP0001730_embryonic_growth_arrest1.58462409
37MP0003137_abnormal_impulse_conducting1.58257029
38MP0003111_abnormal_nucleus_morphology1.58025949
39MP0003806_abnormal_nucleotide_metabolis1.57750767
40MP0000639_abnormal_adrenal_gland1.57393701
41MP0003385_abnormal_body_wall1.52748662
42MP0005620_abnormal_muscle_contractility1.50409884
43* MP0003984_embryonic_growth_retardation1.50024012
44MP0004484_altered_response_of1.49587217
45* MP0002088_abnormal_embryonic_growth/wei1.49148553
46MP0003119_abnormal_digestive_system1.48251822
47MP0003566_abnormal_cell_adhesion1.43366335
48MP0001661_extended_life_span1.43064155
49* MP0005380_embryogenesis_phenotype1.42513755
50* MP0001672_abnormal_embryogenesis/_devel1.42513755
51MP0003718_maternal_effect1.42501066
52MP0009840_abnormal_foam_cell1.41648459
53MP0005623_abnormal_meninges_morphology1.38584460
54MP0005670_abnormal_white_adipose1.38320933
55MP0002269_muscular_atrophy1.33626551
56MP0010234_abnormal_vibrissa_follicle1.32626952
57* MP0002127_abnormal_cardiovascular_syste1.31752748
58MP0003315_abnormal_perineum_morphology1.31689075
59MP0005085_abnormal_gallbladder_physiolo1.28213336
60MP0004085_abnormal_heartbeat1.27679354
61MP0005377_hearing/vestibular/ear_phenot1.26956013
62MP0003878_abnormal_ear_physiology1.26956013
63MP0001666_abnormal_nutrient_absorption1.25504571
64MP0005503_abnormal_tendon_morphology1.22012419
65MP0003077_abnormal_cell_cycle1.20411884
66MP0003115_abnormal_respiratory_system1.18754224
67MP0002106_abnormal_muscle_physiology1.18520351
68MP0009053_abnormal_anal_canal1.17282538
69MP0008260_abnormal_autophagy1.16447781
70MP0000516_abnormal_urinary_system1.16379225
71MP0005367_renal/urinary_system_phenotyp1.16379225
72MP0002249_abnormal_larynx_morphology1.15000110
73MP0008932_abnormal_embryonic_tissue1.14565871
74MP0009250_abnormal_appendicular_skeleto1.13031352
75MP0003937_abnormal_limbs/digits/tail_de1.12934221
76* MP0002086_abnormal_extraembryonic_tissu1.11715113
77MP0005257_abnormal_intraocular_pressure1.09077991
78MP0005409_darkened_coat_color1.07251679
79MP0008995_early_reproductive_senescence1.06518535
80MP0005508_abnormal_skeleton_morphology1.04341458
81* MP0001697_abnormal_embryo_size1.03891517
82* MP0000266_abnormal_heart_morphology1.02237906
83MP0002254_reproductive_system_inflammat0.99429050
84MP0003786_premature_aging0.98735625
85MP0010030_abnormal_orbit_morphology0.97370032
86MP0009697_abnormal_copulation0.97129058
87MP0008438_abnormal_cutaneous_collagen0.95956835
88MP0010329_abnormal_lipoprotein_level0.95846685
89MP0000534_abnormal_ureter_morphology0.94686644
90MP0006036_abnormal_mitochondrial_physio0.94025442
91MP0000762_abnormal_tongue_morphology0.93207645
92MP0000013_abnormal_adipose_tissue0.92963052
93MP0005275_abnormal_skin_tensile0.91723045
94MP0001879_abnormal_lymphatic_vessel0.91307950
95MP0001664_abnormal_digestion0.91087294
96MP0001958_emphysema0.90572697
97MP0005369_muscle_phenotype0.90303117
98* MP0002080_prenatal_lethality0.89223489
99MP0005360_urolithiasis0.88133250
100MP0003935_abnormal_craniofacial_develop0.87919011
101MP0009672_abnormal_birth_weight0.85441695
102MP0004133_heterotaxia0.84702327
103MP0004197_abnormal_fetal_growth/weight/0.84676671
104MP0002932_abnormal_joint_morphology0.84493914
105MP0005365_abnormal_bile_salt0.84201619
106MP0006054_spinal_hemorrhage0.81807374
107MP0002796_impaired_skin_barrier0.81795120
108MP0010094_abnormal_chromosome_stability0.81773554
109MP0000747_muscle_weakness0.81646572
110* MP0002084_abnormal_developmental_patter0.81593349
111MP0002909_abnormal_adrenal_gland0.81501221
112* MP0002085_abnormal_embryonic_tissue0.80971775
113MP0002233_abnormal_nose_morphology0.80258481
114MP0002234_abnormal_pharynx_morphology0.77156186
115MP0005084_abnormal_gallbladder_morpholo0.76639559
116MP0005332_abnormal_amino_acid0.75905692
117MP0004782_abnormal_surfactant_physiolog0.75883268
118MP0004145_abnormal_muscle_electrophysio0.75538684
119MP0003122_maternal_imprinting0.75246072
120MP0006035_abnormal_mitochondrial_morpho0.74998719
121MP0010352_gastrointestinal_tract_polyps0.74921181
122MP0002128_abnormal_blood_circulation0.74703300
123MP0000470_abnormal_stomach_morphology0.73846732
124MP0000477_abnormal_intestine_morphology0.73519919
125MP0009780_abnormal_chondrocyte_physiolo0.73319009
126MP0005023_abnormal_wound_healing0.72952701
127MP0002896_abnormal_bone_mineralization0.72261154
128MP0004510_myositis0.71936844
129MP0003942_abnormal_urinary_system0.71929599
130* MP0001614_abnormal_blood_vessel0.70850767
131MP0004019_abnormal_vitamin_homeostasis0.69987528
132MP0002697_abnormal_eye_size0.68922947
133MP0002139_abnormal_hepatobiliary_system0.67942850
134MP0000049_abnormal_middle_ear0.67716846
135MP0004264_abnormal_extraembryonic_tissu0.67244565
136MP0002098_abnormal_vibrissa_morphology0.67052206
137* MP0002925_abnormal_cardiovascular_devel0.66435489
138MP0005165_increased_susceptibility_to0.65978021
139MP0000767_abnormal_smooth_muscle0.65104925
140MP0003121_genomic_imprinting0.63879745
141MP0000428_abnormal_craniofacial_morphol0.63841762
142MP0000566_synostosis0.63588380

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.63062144
2Sudden death (HP:0001699)5.60871368
3Ventricular tachycardia (HP:0004756)5.42451200
4Ventricular fibrillation (HP:0001663)4.75976798
5Syncope (HP:0001279)4.39276798
6Lipoatrophy (HP:0100578)4.00872510
7Atrial fibrillation (HP:0005110)3.96752102
8Ventricular arrhythmia (HP:0004308)3.91839338
9Bundle branch block (HP:0011710)3.82166104
10Muscle fiber splitting (HP:0003555)3.80265587
11Primary atrial arrhythmia (HP:0001692)3.59870405
12Hyperglycinuria (HP:0003108)3.58896750
13Supraventricular arrhythmia (HP:0005115)3.57996430
14Supraventricular tachycardia (HP:0004755)3.53259016
15Palpitations (HP:0001962)3.39067625
16Atrioventricular block (HP:0001678)3.38387390
17Exercise-induced muscle cramps (HP:0003710)3.37046491
18Hyperglycinemia (HP:0002154)3.32471351
19Subaortic stenosis (HP:0001682)3.31124883
20Abnormality of the left ventricular outflow tract (HP:0011103)3.31124883
21Multiple enchondromatosis (HP:0005701)3.22845769
22Hypoplastic left heart (HP:0004383)3.15414505
23Dilated cardiomyopathy (HP:0001644)3.14737867
24Ileus (HP:0002595)3.04041669
25Heart block (HP:0012722)3.03075471
26Calf muscle hypertrophy (HP:0008981)3.02156409
27Gonadal dysgenesis (HP:0000133)3.00368386
28Abnormal atrioventricular conduction (HP:0005150)2.92771566
29Hypoglycemic coma (HP:0001325)2.88308117
30Abnormality of glycine metabolism (HP:0010895)2.87053541
31Abnormality of serine family amino acid metabolism (HP:0010894)2.87053541
32Prolonged QT interval (HP:0001657)2.80046416
33Malnutrition (HP:0004395)2.76113887
34Abnormality of glutamine family amino acid metabolism (HP:0010902)2.73200547
35Decreased circulating renin level (HP:0003351)2.70268444
36Nausea (HP:0002018)2.69593343
37Abnormality of the calf musculature (HP:0001430)2.61858319
38Palmoplantar keratoderma (HP:0000982)2.52535633
39Neonatal death (HP:0003811)2.49782981
40Breast hypoplasia (HP:0003187)2.49066233
41Rhabdomyolysis (HP:0003201)2.48124587
42Abnormality of carpal bone ossification (HP:0006257)2.44153225
43Muscle hypertrophy of the lower extremities (HP:0008968)2.43539191
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43155697
45Dicarboxylic aciduria (HP:0003215)2.43155697
46Premature rupture of membranes (HP:0001788)2.43032216
47Complement deficiency (HP:0004431)2.41068942
48Myoglobinuria (HP:0002913)2.38934792
49Hepatic necrosis (HP:0002605)2.38258901
50Exercise-induced myalgia (HP:0003738)2.36603058
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35219698
52Abnormality of alanine metabolism (HP:0010916)2.35219698
53Hyperalaninemia (HP:0003348)2.35219698
54Hyporeflexia of lower limbs (HP:0002600)2.34900004
55Proximal tubulopathy (HP:0000114)2.33376951
56Short humerus (HP:0005792)2.33349418
57Abnormality of the pulmonary veins (HP:0011718)2.31046825
58Aortic dissection (HP:0002647)2.30425975
59Abnormal EKG (HP:0003115)2.29533164
60Asymmetric septal hypertrophy (HP:0001670)2.29432541
61Abnormal tarsal ossification (HP:0008369)2.29147470
62Anomalous pulmonary venous return (HP:0010772)2.28165387
63Abnormality of fatty-acid metabolism (HP:0004359)2.26927740
64Testicular neoplasm (HP:0010788)2.25548566
65Hypoplastic heart (HP:0001961)2.25025321
66Aplasia/hypoplasia of the humerus (HP:0006507)2.23332521
67* Patent foramen ovale (HP:0001655)2.21020210
68Anteriorly placed anus (HP:0001545)2.19659806
69Preaxial foot polydactyly (HP:0001841)2.19330751
70Abnormality of proline metabolism (HP:0010907)2.16694946
71Hydroxyprolinuria (HP:0003080)2.16694946
72Abnormality of serum amino acid levels (HP:0003112)2.14244715
73Hypoalphalipoproteinemia (HP:0003233)2.12967924
74Abnormal vertebral ossification (HP:0100569)2.11651745
75* Periauricular skin pits (HP:0100277)2.10684968
76* Preauricular pit (HP:0004467)2.10684968
77Ragged-red muscle fibers (HP:0003200)2.09416417
78Difficulty climbing stairs (HP:0003551)2.08935556
79Areflexia of lower limbs (HP:0002522)2.08550858
80Abnormality of complement system (HP:0005339)2.07499502
81Pulmonary artery stenosis (HP:0004415)2.06630345
82Ulnar bowing (HP:0003031)2.06263510
83Increased connective tissue (HP:0009025)2.05575935
84Hypolipoproteinemia (HP:0010981)2.05041415
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.04439449
86Anal stenosis (HP:0002025)2.04306262
87Abnormal hand bone ossification (HP:0010660)2.03229296
88Rectal prolapse (HP:0002035)2.02472355
89Hypoplasia of the uterus (HP:0000013)2.00389110
90Gout (HP:0001997)1.98181210
91Abnormal ossification of hand bones (HP:0005921)1.98033491
92Progressive muscle weakness (HP:0003323)1.97868636
93Ankle contracture (HP:0006466)1.96497394
94Mitral stenosis (HP:0001718)1.95992156
95Abnormality of the distal phalanges of the toes (HP:0010182)1.95778758
96Short clavicles (HP:0000894)1.95219229
97Aortic aneurysm (HP:0004942)1.92573435
98Abnormality of monocarboxylic acid metabolism (HP:0010996)1.92549005
99* Abnormal connection of the cardiac segments (HP:0011545)1.92160277
100* Abnormal ventriculo-arterial connection (HP:0011563)1.92160277
101* Transposition of the great arteries (HP:0001669)1.92160277
102* Abnormal pancreas size (HP:0012094)1.92126167
103Abnormal cartilage morphology (HP:0002763)1.91522469
104Premature ovarian failure (HP:0008209)1.91479927
105Fragile skin (HP:0001030)1.91223214
106Mitral valve prolapse (HP:0001634)1.89716590
107Flat acetabular roof (HP:0003180)1.89309915
108* Abnormality of the fetal cardiovascular system (HP:0010948)1.88864399
109* Abnormal umbilical cord blood vessels (HP:0011403)1.88864399
110* Single umbilical artery (HP:0001195)1.88864399
111Myelomeningocele (HP:0002475)1.88653578
112Abnormality of vitamin metabolism (HP:0100508)1.87787842
113Hyperaldosteronism (HP:0000859)1.87225944
114Natal tooth (HP:0000695)1.85446926
115Soft skin (HP:0000977)1.85307416
116EMG: myopathic abnormalities (HP:0003458)1.84728519
117Abnormal foot bone ossification (HP:0010675)1.84648179
118Lymphangioma (HP:0100764)1.84565890
119Abnormality of the anterior horn cell (HP:0006802)1.84262938
120Degeneration of anterior horn cells (HP:0002398)1.84262938
121Carpal bone hypoplasia (HP:0001498)1.83738581
122Rough bone trabeculation (HP:0100670)1.83223799
123Abnormality of the middle phalanges of the toes (HP:0010183)1.82813239
124Abnormality of glycolysis (HP:0004366)1.82374960
125Increased serum pyruvate (HP:0003542)1.82374960
126* Congenital malformation of the right heart (HP:0011723)1.82261507
127* Double outlet right ventricle (HP:0001719)1.82261507
128Deviation of the thumb (HP:0009603)1.81712114
129Secondary amenorrhea (HP:0000869)1.81063937
130Diastasis recti (HP:0001540)1.80970744
131Renal salt wasting (HP:0000127)1.80562337
132Short middle phalanx of the 5th finger (HP:0004220)1.79625654
133Short nail (HP:0001799)1.79621830
134Impulsivity (HP:0100710)1.79587991
135Trismus (HP:0000211)1.78752285
136Generalized aminoaciduria (HP:0002909)1.77152388
137Congenital, generalized hypertrichosis (HP:0004540)1.76616575
138Short hallux (HP:0010109)1.76126820
139* Hyperglycemia (HP:0003074)1.76018225
140Diaphragmatic weakness (HP:0009113)1.75596984
141* Abnormality of the umbilical cord (HP:0010881)1.75377460
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.74244764
143Abnormality of vitamin B metabolism (HP:0004340)1.73865667
144Partial duplication of thumb phalanx (HP:0009944)1.73829079
145Hyperammonemia (HP:0001987)1.73050062
146Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72521739
147* Skin pits (HP:0100276)1.72017957
148Ectopic anus (HP:0004397)1.71046004
149Lethargy (HP:0001254)1.69093709
150Cervical subluxation (HP:0003308)1.68826310
151Hypobetalipoproteinemia (HP:0003563)1.68704887
152Limited hip movement (HP:0008800)1.68655297
153Vertebral clefting (HP:0008428)1.67992961
154Protrusio acetabuli (HP:0003179)1.67887165
155Neck muscle weakness (HP:0000467)1.67412395
156Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66040426
157Tracheal stenosis (HP:0002777)1.65983882
158Neonatal short-limb short stature (HP:0008921)1.65299249
159Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65123079
160Vascular tortuosity (HP:0004948)1.64849143
161Mildly elevated creatine phosphokinase (HP:0008180)1.64833264
162CNS demyelination (HP:0007305)1.64353491
163* Ureteral duplication (HP:0000073)1.61651365
164Hepatocellular necrosis (HP:0001404)1.60721633
165Testicular atrophy (HP:0000029)1.60038332
166Polycythemia (HP:0001901)1.58189513
167Birth length less than 3rd percentile (HP:0003561)1.57604140
168Rimmed vacuoles (HP:0003805)1.56907937
169Increased CSF lactate (HP:0002490)1.56837046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK243.76873733
2STK38L3.33213317
3OBSCN3.27295546
4WEE12.94701272
5MYLK2.87873366
6EPHA22.70644106
7PDK42.53727675
8PDK32.53727675
9BUB12.45680099
10ZAK2.44990564
11AKT32.39520866
12LMTK22.28772249
13NME22.13908301
14BRSK22.08050744
15NEK12.06183067
16NUAK12.03686029
17RIPK11.96636207
18LATS11.93068563
19STK391.91309219
20TRIB31.89897442
21PBK1.80961878
22PKN21.80811884
23EPHB21.75040563
24TTK1.68602317
25PDK21.66673331
26STK31.65229443
27MAP3K31.64328206
28DDR21.61776732
29TRIM281.57451348
30TNIK1.56626107
31TTN1.55881163
32ERBB41.54780066
33BCKDK1.50154654
34ILK1.44580259
35NEK21.42410199
36TIE11.39989644
37TSSK61.34580613
38EIF2AK11.31859382
39LATS21.31755242
40PLK41.25509320
41ACVR1B1.25318785
42PLK31.21159134
43PRPF4B1.20581604
44MAP3K121.20437901
45MST1R1.19819669
46PTK21.18985171
47SRPK11.18857853
48ERN11.16800150
49MAP2K21.14232039
50AURKB1.12648962
51DMPK1.12541055
52PLK11.09687652
53NME11.08614722
54ICK1.06044306
55CDK41.05352493
56MAP3K101.01890555
57BRSK10.95070797
58PIK3CA0.90866116
59STK40.86670071
60MUSK0.85481629
61NLK0.80404361
62BRAF0.80120470
63FLT30.78833496
64MELK0.76431707
65CDC42BPA0.75725339
66TESK10.75209325
67EIF2AK30.74158531
68WNK40.73058778
69NEK90.71876717
70MAP3K80.70531163
71RPS6KA40.70120158
72PRKCI0.69864853
73FGFR40.69598780
74MAP3K60.69060986
75MET0.68440996
76LIMK10.68321784
77PAK20.67616555
78AURKA0.67143021
79TAOK20.66002116
80FER0.65558243
81MKNK20.64973095
82ROCK20.64056738
83TGFBR20.62765500
84MST40.60866683
85CAMK40.60603727
86DYRK30.58694189
87MAP3K50.56968773
88ARAF0.55306585
89PTK60.55075630
90PAK30.54399482
91PAK40.54247815
92PRKG20.50838312
93RPS6KB20.49476869
94PRKCE0.49371785
95CHEK20.48359072
96PAK10.48034025
97PRKAA10.47545083
98CDK70.47143800
99KDR0.45670686
100BMPR1B0.44803852
101MTOR0.44516628
102MAP3K110.43989771
103STK100.43685930
104PDPK10.43582219
105PRKD10.43294665
106PINK10.43270229
107ROCK10.43259588
108DAPK30.43239900
109PDGFRA0.43028735
110PRKAA20.42916179
111MAP3K20.42539628
112FRK0.42321933
113TRPM70.41553718
114PASK0.41331497
115MKNK10.41165182
116OXSR10.39662928
117TGFBR10.39559552
118AKT20.39329085
119LRRK20.38840943
120CSNK2A10.38485434
121MAP2K30.37181847
122MAP2K10.37137300
123PRKD30.37045845
124MARK30.35361719
125STK380.35066831
126RPS6KL10.34780010
127RPS6KC10.34780010
128FGFR10.34521595
129CHEK10.34111633
130CAMK2D0.34111483
131SIK10.30904402
132ABL20.29857705
133FGFR20.27948316
134WNK10.27854343
135PNCK0.27774570
136PDGFRB0.26633112

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.73162629
2Proteasome_Homo sapiens_hsa030503.05197927
3Vitamin B6 metabolism_Homo sapiens_hsa007502.75145942
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.74423643
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72737464
6Sulfur metabolism_Homo sapiens_hsa009202.53638804
7RNA polymerase_Homo sapiens_hsa030202.53290745
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.23740273
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21895056
10Cardiac muscle contraction_Homo sapiens_hsa042602.16990149
11Carbon metabolism_Homo sapiens_hsa012002.14853500
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.09334191
13RNA transport_Homo sapiens_hsa030132.01986472
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.96136178
15Steroid biosynthesis_Homo sapiens_hsa001001.94730049
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89805503
17Ovarian steroidogenesis_Homo sapiens_hsa049131.89710523
18Fat digestion and absorption_Homo sapiens_hsa049751.89188695
19Ribosome_Homo sapiens_hsa030101.87352810
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.83991497
21Fatty acid degradation_Homo sapiens_hsa000711.83727079
22Fructose and mannose metabolism_Homo sapiens_hsa000511.71861913
23Parkinsons disease_Homo sapiens_hsa050121.68905901
24Dilated cardiomyopathy_Homo sapiens_hsa054141.64997235
25Propanoate metabolism_Homo sapiens_hsa006401.62350552
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60222750
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.59189058
28Bile secretion_Homo sapiens_hsa049761.51181000
29Oxidative phosphorylation_Homo sapiens_hsa001901.49588842
30Pyrimidine metabolism_Homo sapiens_hsa002401.49383846
31Galactose metabolism_Homo sapiens_hsa000521.49351702
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47011280
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39272063
34Huntingtons disease_Homo sapiens_hsa050161.38903477
35Biosynthesis of amino acids_Homo sapiens_hsa012301.38805997
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37769497
37Regulation of autophagy_Homo sapiens_hsa041401.34886782
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33494256
39Pentose phosphate pathway_Homo sapiens_hsa000301.31010537
40Folate biosynthesis_Homo sapiens_hsa007901.30553126
41Glutathione metabolism_Homo sapiens_hsa004801.29918569
42Retinol metabolism_Homo sapiens_hsa008301.28553283
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28314313
44Tight junction_Homo sapiens_hsa045301.26181732
45Vitamin digestion and absorption_Homo sapiens_hsa049771.24952507
46Chemical carcinogenesis_Homo sapiens_hsa052041.23482553
47Cell cycle_Homo sapiens_hsa041101.20771917
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20262522
49Fatty acid metabolism_Homo sapiens_hsa012121.17369003
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13026185
51Histidine metabolism_Homo sapiens_hsa003401.09146090
52Phenylalanine metabolism_Homo sapiens_hsa003601.08711198
53Complement and coagulation cascades_Homo sapiens_hsa046101.07829098
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.05087672
55Spliceosome_Homo sapiens_hsa030401.05069699
56DNA replication_Homo sapiens_hsa030301.03475630
57Starch and sucrose metabolism_Homo sapiens_hsa005001.03317422
58Arginine and proline metabolism_Homo sapiens_hsa003301.01817749
59Pancreatic secretion_Homo sapiens_hsa049721.01804375
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01355150
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00808138
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.00514376
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00154178
64Sulfur relay system_Homo sapiens_hsa041220.99208171
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98725561
66Purine metabolism_Homo sapiens_hsa002300.94605812
67Hippo signaling pathway_Homo sapiens_hsa043900.94189431
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93195570
69Mismatch repair_Homo sapiens_hsa034300.92920392
70Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91876557
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.91573027
72Pyruvate metabolism_Homo sapiens_hsa006200.90115008
73Basal transcription factors_Homo sapiens_hsa030220.88064127
74Arachidonic acid metabolism_Homo sapiens_hsa005900.87184092
75ECM-receptor interaction_Homo sapiens_hsa045120.87052763
76Alzheimers disease_Homo sapiens_hsa050100.86951189
77Nucleotide excision repair_Homo sapiens_hsa034200.84542358
78Adherens junction_Homo sapiens_hsa045200.84524273
79Protein digestion and absorption_Homo sapiens_hsa049740.84008373
80Selenocompound metabolism_Homo sapiens_hsa004500.82077396
81Small cell lung cancer_Homo sapiens_hsa052220.78804113
82PPAR signaling pathway_Homo sapiens_hsa033200.77606485
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77302568
84beta-Alanine metabolism_Homo sapiens_hsa004100.76099301
85Mineral absorption_Homo sapiens_hsa049780.73453790
86Base excision repair_Homo sapiens_hsa034100.69972632
87Homologous recombination_Homo sapiens_hsa034400.69133595
88Linoleic acid metabolism_Homo sapiens_hsa005910.67765617
89Tryptophan metabolism_Homo sapiens_hsa003800.66616883
90Sphingolipid metabolism_Homo sapiens_hsa006000.66523165
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64551388
92Metabolic pathways_Homo sapiens_hsa011000.64264705
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.63130515
94RNA degradation_Homo sapiens_hsa030180.63026749
95Wnt signaling pathway_Homo sapiens_hsa043100.62653163
96Renin-angiotensin system_Homo sapiens_hsa046140.62284872
97Proteoglycans in cancer_Homo sapiens_hsa052050.60959390
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.60744568
99Butanoate metabolism_Homo sapiens_hsa006500.60328419
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59227363
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58303002
102Fatty acid elongation_Homo sapiens_hsa000620.57934896
103p53 signaling pathway_Homo sapiens_hsa041150.57269056
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.55891900
105One carbon pool by folate_Homo sapiens_hsa006700.55154409
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54391096
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53938530
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53792234
109Protein export_Homo sapiens_hsa030600.53754809
110TGF-beta signaling pathway_Homo sapiens_hsa043500.53303451
111Basal cell carcinoma_Homo sapiens_hsa052170.52319603
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52181137
113Tyrosine metabolism_Homo sapiens_hsa003500.50451448
114mRNA surveillance pathway_Homo sapiens_hsa030150.49461788
115Arginine biosynthesis_Homo sapiens_hsa002200.47851801
116Focal adhesion_Homo sapiens_hsa045100.47028475
117Prion diseases_Homo sapiens_hsa050200.46881438
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.45821554
119Hedgehog signaling pathway_Homo sapiens_hsa043400.45492758
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45174750
121Vibrio cholerae infection_Homo sapiens_hsa051100.44976135
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40845640
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40402288
124Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40259163
125Insulin resistance_Homo sapiens_hsa049310.40017733
126HIF-1 signaling pathway_Homo sapiens_hsa040660.39882220
127Amoebiasis_Homo sapiens_hsa051460.39336875
128Oocyte meiosis_Homo sapiens_hsa041140.39275665
129Glycerolipid metabolism_Homo sapiens_hsa005610.38410468
130Caffeine metabolism_Homo sapiens_hsa002320.38125614
131Peroxisome_Homo sapiens_hsa041460.38077039
132Lysine degradation_Homo sapiens_hsa003100.37671926
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37658649
134Epstein-Barr virus infection_Homo sapiens_hsa051690.37282778
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36449563
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35378456
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35304538
138Glucagon signaling pathway_Homo sapiens_hsa049220.34285196
139Thyroid hormone synthesis_Homo sapiens_hsa049180.34115218

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