GATA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.17871306
2protoporphyrinogen IX biosynthetic process (GO:0006782)8.70817088
3oxygen transport (GO:0015671)7.75927570
4gas transport (GO:0015669)7.49595647
5heme biosynthetic process (GO:0006783)7.25099098
6porphyrin-containing compound biosynthetic process (GO:0006779)7.22904823
7tetrapyrrole biosynthetic process (GO:0033014)6.42780269
8erythrocyte maturation (GO:0043249)5.84703795
9heme metabolic process (GO:0042168)5.73984369
10porphyrin-containing compound metabolic process (GO:0006778)5.71269654
11definitive hemopoiesis (GO:0060216)5.62762104
12DNA deamination (GO:0045006)5.27409854
13positive regulation of granulocyte differentiation (GO:0030854)4.54897351
14DNA replication initiation (GO:0006270)4.54525419
15ribosomal small subunit assembly (GO:0000028)4.38174862
16positive regulation of B cell differentiation (GO:0045579)4.31773924
17DNA strand elongation involved in DNA replication (GO:0006271)4.31727343
18DNA topological change (GO:0006265)4.28838578
19DNA replication checkpoint (GO:0000076)4.28183827
20oxidative phosphorylation (GO:0006119)4.20995921
21telomere maintenance via semi-conservative replication (GO:0032201)4.18811764
22hemoglobin metabolic process (GO:0020027)4.17286223
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.14483940
24DNA strand elongation (GO:0022616)4.10205158
25megakaryocyte development (GO:0035855)4.03653740
26CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.99751866
27positive regulation of megakaryocyte differentiation (GO:0045654)3.90271117
28* embryonic hemopoiesis (GO:0035162)3.88360402
29viral transcription (GO:0019083)3.87865566
30pigment biosynthetic process (GO:0046148)3.87514270
31mitochondrial calcium ion transport (GO:0006851)3.80244981
32CENP-A containing nucleosome assembly (GO:0034080)3.79315205
33translational termination (GO:0006415)3.77745903
34protein localization to chromosome, centromeric region (GO:0071459)3.77242345
35proteasome assembly (GO:0043248)3.73613588
36tetrapyrrole metabolic process (GO:0033013)3.72097942
37* granulocyte differentiation (GO:0030851)3.67231012
38* erythrocyte differentiation (GO:0030218)3.66039183
39valine metabolic process (GO:0006573)3.63905227
40regulation of histone H3-K4 methylation (GO:0051569)3.62088830
41mitotic nuclear envelope reassembly (GO:0007084)3.60759448
42nuclear envelope reassembly (GO:0031468)3.60759448
43chromatin remodeling at centromere (GO:0031055)3.55724777
44* regulation of erythrocyte differentiation (GO:0045646)3.55202563
45positive regulation of gamma-delta T cell activation (GO:0046645)3.54045774
46protein localization to kinetochore (GO:0034501)3.51334084
47telomere maintenance via recombination (GO:0000722)3.50734434
48DNA replication-independent nucleosome organization (GO:0034724)3.50387890
49DNA replication-independent nucleosome assembly (GO:0006336)3.50387890
50DNA unwinding involved in DNA replication (GO:0006268)3.50174571
51maturation of SSU-rRNA (GO:0030490)3.50008049
52mitotic sister chromatid segregation (GO:0000070)3.49543238
53translational elongation (GO:0006414)3.43404911
54positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.39224838
55mitotic metaphase plate congression (GO:0007080)3.39161890
56IMP biosynthetic process (GO:0006188)3.37845911
57translational initiation (GO:0006413)3.36679454
58aerobic respiration (GO:0009060)3.34522282
59positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.34128016
60* erythrocyte development (GO:0048821)3.33885166
61formation of translation preinitiation complex (GO:0001731)3.32154484
62viral mRNA export from host cell nucleus (GO:0046784)3.31870684
63ribosome biogenesis (GO:0042254)3.29453855
64kinetochore organization (GO:0051383)3.28590974
65mitotic nuclear envelope disassembly (GO:0007077)3.28247937
66potassium ion export (GO:0071435)3.27741912
67purine-containing compound salvage (GO:0043101)3.25419280
68neutrophil activation involved in immune response (GO:0002283)3.24798918
69mitotic recombination (GO:0006312)3.22639908
70pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22368788
71regulation of exit from mitosis (GO:0007096)3.21021010
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.19156837
73ribosomal small subunit biogenesis (GO:0042274)3.19084203
74* myeloid cell development (GO:0061515)3.19056074
75kinetochore assembly (GO:0051382)3.18620429
76deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18163236
77ribonucleoprotein complex biogenesis (GO:0022613)3.17107669
78negative regulation of erythrocyte differentiation (GO:0045647)3.16761866
79pigment metabolic process (GO:0042440)3.15742234
80pseudouridine synthesis (GO:0001522)3.14762096
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14044971
82attachment of spindle microtubules to kinetochore (GO:0008608)3.13315524
83nucleobase biosynthetic process (GO:0046112)3.12911637
84one-carbon compound transport (GO:0019755)3.09867360
85telomere maintenance via telomere lengthening (GO:0010833)3.09179320
86positive regulation of chromosome segregation (GO:0051984)3.08491580
87negative regulation of translational initiation (GO:0045947)3.08063088
88cotranslational protein targeting to membrane (GO:0006613)3.05716312
89protein targeting to ER (GO:0045047)3.05482993
90proline biosynthetic process (GO:0006561)3.04939885
91regulation of histone H3-K9 methylation (GO:0051570)3.04793764
92folic acid-containing compound biosynthetic process (GO:0009396)3.04278116
93histone exchange (GO:0043486)3.03275888
94response to insecticide (GO:0017085)3.03115544
95membrane disassembly (GO:0030397)3.02757752
96nuclear envelope disassembly (GO:0051081)3.02757752
97sister chromatid segregation (GO:0000819)3.02497029
98cellular protein complex disassembly (GO:0043624)3.01073876
99Peyers patch development (GO:0048541)3.00536431
100mucosal-associated lymphoid tissue development (GO:0048537)3.00536431
101ribosomal large subunit biogenesis (GO:0042273)3.00240074
102viral life cycle (GO:0019058)2.98510670
103rRNA modification (GO:0000154)2.98407880
104folic acid metabolic process (GO:0046655)2.98378574
105purine nucleobase biosynthetic process (GO:0009113)2.96013287
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.94069009
107rRNA processing (GO:0006364)2.94017444
108centriole replication (GO:0007099)2.92803589
109regulation of megakaryocyte differentiation (GO:0045652)2.91822714
110metaphase plate congression (GO:0051310)2.91732355
111response to lead ion (GO:0010288)2.91727651
112protein localization to endoplasmic reticulum (GO:0070972)2.90547461
113poly(A)+ mRNA export from nucleus (GO:0016973)2.90540050
114DNA replication-dependent nucleosome organization (GO:0034723)2.90187082
115DNA replication-dependent nucleosome assembly (GO:0006335)2.90187082
116rRNA metabolic process (GO:0016072)2.89934749
117negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.88040867
118T cell lineage commitment (GO:0002360)2.87970751
119adenine nucleotide transport (GO:0051503)2.86739000
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86694681
121mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86677767
122mitochondrial respiratory chain complex I assembly (GO:0032981)2.86677767
123NADH dehydrogenase complex assembly (GO:0010257)2.86677767
124chromatin assembly or disassembly (GO:0006333)2.85693729
125negative regulation of RNA splicing (GO:0033119)2.85425080
126regulation of spindle organization (GO:0090224)2.84125042
127deoxyribose phosphate biosynthetic process (GO:0046385)2.81612756
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.81612756
129IMP metabolic process (GO:0046040)2.81437115
130negative regulation of histone methylation (GO:0031061)2.81377624
131pentose-phosphate shunt (GO:0006098)2.79800064
132regulation of mast cell degranulation (GO:0043304)2.79204339
133translesion synthesis (GO:0019985)2.78949094
134purine ribonucleotide transport (GO:0015868)2.78890733
135* platelet formation (GO:0030220)2.78376859
136spliceosomal snRNP assembly (GO:0000387)2.77030546
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.75916434
138purine nucleotide salvage (GO:0032261)2.75570699
139atrioventricular valve morphogenesis (GO:0003181)2.74999131
140creatine metabolic process (GO:0006600)2.74968039
141mitotic chromosome condensation (GO:0007076)2.74157527
142regulation of gamma-delta T cell differentiation (GO:0045586)2.73531748
143nuclear pore complex assembly (GO:0051292)2.69400313
144regulation of response to osmotic stress (GO:0047484)2.69064111
145centriole assembly (GO:0098534)2.66936259
146hematopoietic stem cell differentiation (GO:0060218)2.64400205
147regulation of granulocyte differentiation (GO:0030852)2.63000233
148succinate metabolic process (GO:0006105)2.62695282
149tricarboxylic acid metabolic process (GO:0072350)2.59570807
150positive regulation of histone methylation (GO:0031062)2.58595096
151regulation of mast cell activation involved in immune response (GO:0033006)2.55465881
152pentose metabolic process (GO:0019321)2.53755628
153oxaloacetate metabolic process (GO:0006107)2.49134311
154positive regulation of natural killer cell differentiation (GO:0032825)2.48528547
155regulation of RNA export from nucleus (GO:0046831)2.45099114
156thrombin receptor signaling pathway (GO:0070493)2.44500637
157iron ion import (GO:0097286)2.43665636
158respiratory chain complex IV assembly (GO:0008535)2.39594255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.85129356
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.86936141
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.94424355
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.37930971
5GATA1_22025678_ChIP-Seq_K562_Human3.36969788
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.35686111
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91266257
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.62763519
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55331863
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.55314714
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50972360
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.50557757
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45874507
14SCL_19346495_ChIP-Seq_HPC-7_Human2.44264854
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.42857416
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23264047
17SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23086224
18TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.22907621
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22306902
20* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.18326378
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16159815
22VDR_23849224_ChIP-Seq_CD4+_Human2.14075083
23XRN2_22483619_ChIP-Seq_HELA_Human2.08953062
24MYC_22102868_ChIP-Seq_BL_Human2.07145130
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03508478
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02520999
27* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.95165375
28* GATA1_19941827_ChIP-Seq_MEL_Mouse1.93389428
29NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90550650
30FOXP3_21729870_ChIP-Seq_TREG_Human1.88318661
31CIITA_25753668_ChIP-Seq_RAJI_Human1.85807068
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85214888
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.84041506
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83376379
35GABP_19822575_ChIP-Seq_HepG2_Human1.81936312
36DCP1A_22483619_ChIP-Seq_HELA_Human1.78872419
37AR_21909140_ChIP-Seq_LNCAP_Human1.77204963
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74699253
39SPI1_23127762_ChIP-Seq_K562_Human1.73144053
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65801992
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65541765
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64718720
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63377519
44* GATA1_19941826_ChIP-Seq_K562_Human1.62524179
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59798376
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58509692
47VDR_21846776_ChIP-Seq_THP-1_Human1.57511588
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56216110
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54612496
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53780502
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.53565738
52TTF2_22483619_ChIP-Seq_HELA_Human1.53151593
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50348308
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49818967
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.49725774
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49171627
57KDM5A_27292631_Chip-Seq_BREAST_Human1.49121563
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47192706
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44010614
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42550498
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.42225905
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36615286
63* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34372994
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.33867303
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31477747
66* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26852695
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26543099
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26316728
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23714576
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23687837
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22504018
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.21805668
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21361545
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21183807
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20339766
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19218460
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17984005
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17612872
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13852247
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13828561
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13401699
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12945325
83TFEB_21752829_ChIP-Seq_HELA_Human1.12271380
84* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11839859
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11445897
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10647260
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10594309
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10045000
89ELK1_19687146_ChIP-ChIP_HELA_Human1.09551902
90ZNF263_19887448_ChIP-Seq_K562_Human1.08882666
91* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08427208
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.07783438
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.07364662
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.07199467
95P68_20966046_ChIP-Seq_HELA_Human1.02954623
96MYB_26560356_Chip-Seq_TH1_Human1.01005910
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00781610
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00556266
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99763125
100CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99341262
101SPI1_23547873_ChIP-Seq_NB4_Human0.96356183
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95455342
103MAF_26560356_Chip-Seq_TH1_Human0.95262281
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95204119
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.94629795
106FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94400689
107* BCOR_27268052_Chip-Seq_Bcells_Human0.94263830
108MYB_21317192_ChIP-Seq_ERMYB_Mouse0.93619582
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92786950
110LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92157474
111UTX_26944678_Chip-Seq_JUKART_Human0.88015331
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87975391
113CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86840603
114MAF_26560356_Chip-Seq_TH2_Human0.86822752
115* GATA2_19941826_ChIP-Seq_K562_Human0.86227844
116PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86197352
117ELF1_20517297_ChIP-Seq_JURKAT_Human0.86147677
118* NCOR1_26117541_ChIP-Seq_K562_Human0.84447624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo7.97879877
2MP0004147_increased_porphyrin_level7.28991437
3MP0003693_abnormal_embryo_hatching4.26644092
4* MP0003111_abnormal_nucleus_morphology4.05871316
5MP0010094_abnormal_chromosome_stability3.51101089
6MP0002396_abnormal_hematopoietic_system3.28924200
7MP0004957_abnormal_blastocyst_morpholog3.14790742
8MP0003077_abnormal_cell_cycle3.09858143
9* MP0001545_abnormal_hematopoietic_system2.97223793
10* MP0005397_hematopoietic_system_phenotyp2.97223793
11MP0008057_abnormal_DNA_replication2.88400643
12MP0006054_spinal_hemorrhage2.69266936
13MP0001661_extended_life_span2.28073423
14MP0000490_abnormal_crypts_of2.26873610
15MP0008058_abnormal_DNA_repair2.21162896
16MP0008007_abnormal_cellular_replicative2.03170823
17MP0009697_abnormal_copulation1.86428275
18MP0000465_gastrointestinal_hemorrhage1.81049887
19MP0009333_abnormal_splenocyte_physiolog1.77277007
20MP0005377_hearing/vestibular/ear_phenot1.69084016
21MP0003878_abnormal_ear_physiology1.69084016
22* MP0002398_abnormal_bone_marrow1.68765269
23MP0003786_premature_aging1.68212895
24MP0010307_abnormal_tumor_latency1.63701421
25MP0006036_abnormal_mitochondrial_physio1.61666876
26MP0004808_abnormal_hematopoietic_stem1.60931928
27MP0001730_embryonic_growth_arrest1.59007106
28MP0005083_abnormal_biliary_tract1.58491896
29MP0005464_abnormal_platelet_physiology1.55663036
30MP0004145_abnormal_muscle_electrophysio1.55205451
31MP0000350_abnormal_cell_proliferation1.54939134
32MP0000678_abnormal_parathyroid_gland1.51923409
33* MP0002722_abnormal_immune_system1.49426646
34MP0003303_peritoneal_inflammation1.47008710
35* MP0000313_abnormal_cell_death1.46247113
36MP0008932_abnormal_embryonic_tissue1.44893760
37* MP0000689_abnormal_spleen_morphology1.41575564
38MP0003186_abnormal_redox_activity1.41574708
39MP0003806_abnormal_nucleotide_metabolis1.39426285
40* MP0005636_abnormal_mineral_homeostasis1.34898584
41MP0000015_abnormal_ear_pigmentation1.33791762
42MP0000372_irregular_coat_pigmentation1.32925610
43MP0005451_abnormal_body_composition1.31989465
44MP0010352_gastrointestinal_tract_polyps1.28823680
45MP0002019_abnormal_tumor_incidence1.28604931
46* MP0002429_abnormal_blood_cell1.27342619
47* MP0002080_prenatal_lethality1.26300606
48MP0003436_decreased_susceptibility_to1.21200371
49MP0003718_maternal_effect1.17576008
50MP0008877_abnormal_DNA_methylation1.17517685
51MP0008004_abnormal_stomach_pH1.16653848
52MP0005310_abnormal_salivary_gland1.15179655
53* MP0001697_abnormal_embryo_size1.09529395
54MP0000703_abnormal_thymus_morphology1.09266748
55MP0005075_abnormal_melanosome_morpholog1.06766456
56* MP0002086_abnormal_extraembryonic_tissu1.01305585
57MP0008775_abnormal_heart_ventricle1.00164530
58MP0003866_abnormal_defecation0.96576092
59MP0003123_paternal_imprinting0.94144050
60MP0009840_abnormal_foam_cell0.94052477
61MP0009278_abnormal_bone_marrow0.93527997
62MP0005380_embryogenesis_phenotype0.93407009
63MP0001672_abnormal_embryogenesis/_devel0.93407009
64MP0008260_abnormal_autophagy0.90225322
65MP0005671_abnormal_response_to0.89953979
66MP0003300_gastrointestinal_ulcer0.89577042
67MP0006035_abnormal_mitochondrial_morpho0.88899179
68* MP0009931_abnormal_skin_appearance0.88268786
69MP0003984_embryonic_growth_retardation0.88128199
70* MP0000716_abnormal_immune_system0.87258661
71MP0005410_abnormal_fertilization0.87152902
72MP0000358_abnormal_cell_content/0.86978993
73MP0005025_abnormal_response_to0.86927399
74MP0003763_abnormal_thymus_physiology0.86493040
75MP0001915_intracranial_hemorrhage0.86288754
76MP0001873_stomach_inflammation0.85171146
77MP0002088_abnormal_embryonic_growth/wei0.84874388
78MP0002095_abnormal_skin_pigmentation0.84529605
79MP0000343_altered_response_to0.83883229
80MP0002102_abnormal_ear_morphology0.82867448
81MP0004215_abnormal_myocardial_fiber0.82811838
82MP0005646_abnormal_pituitary_gland0.82353883
83* MP0008770_decreased_survivor_rate0.81526747
84MP0002419_abnormal_innate_immunity0.78246426
85MP0003879_abnormal_hair_cell0.77867651
86MP0005584_abnormal_enzyme/coenzyme_acti0.76299742
87MP0005171_absent_coat_pigmentation0.75351636
88MP0002210_abnormal_sex_determination0.75139320
89MP0000685_abnormal_immune_system0.74380257
90MP0008995_early_reproductive_senescence0.73406806
91MP0009763_increased_sensitivity_to0.73075806
92MP0009765_abnormal_xenobiotic_induced0.72256972
93MP0002877_abnormal_melanocyte_morpholog0.72217890
94MP0005535_abnormal_body_temperature0.72129422
95* MP0000598_abnormal_liver_morphology0.71523075
96MP0000609_abnormal_liver_physiology0.71259006
97MP0001929_abnormal_gametogenesis0.70930332
98MP0002405_respiratory_system_inflammati0.70804141
99MP0005000_abnormal_immune_tolerance0.70542214
100MP0003172_abnormal_lysosome_physiology0.69834472
101MP0001145_abnormal_male_reproductive0.69718241
102MP0003191_abnormal_cellular_cholesterol0.68036897
103MP0001764_abnormal_homeostasis0.67570242
104MP0005501_abnormal_skin_physiology0.66111399
105MP0002970_abnormal_white_adipose0.65086503
106MP0005384_cellular_phenotype0.64843911
107MP0003221_abnormal_cardiomyocyte_apopto0.63679612
108MP0000653_abnormal_sex_gland0.62817008
109MP0004947_skin_inflammation0.62688233
110MP0002085_abnormal_embryonic_tissue0.62453314
111MP0005621_abnormal_cell_physiology0.62011926
112MP0008874_decreased_physiological_sensi0.61586902
113MP0002420_abnormal_adaptive_immunity0.58680000
114MP0003567_abnormal_fetal_cardiomyocyte0.58625943
115MP0002452_abnormal_antigen_presenting0.58434884
116MP0001853_heart_inflammation0.58334354
117MP0009764_decreased_sensitivity_to0.57973319
118MP0005174_abnormal_tail_pigmentation0.57779157
119MP0001663_abnormal_digestive_system0.57646760
120MP0003698_abnormal_male_reproductive0.57473402
121MP0001819_abnormal_immune_cell0.57329923
122MP0001727_abnormal_embryo_implantation0.57269772
123MP0000747_muscle_weakness0.56969915
124MP0005360_urolithiasis0.56078334
125MP0005647_abnormal_sex_gland0.55303999
126MP0001881_abnormal_mammary_gland0.55023331
127MP0000681_abnormal_thyroid_gland0.54482222
128MP0001293_anophthalmia0.53960219
129MP0001529_abnormal_vocalization0.52369595
130MP0002084_abnormal_developmental_patter0.52358566
131* MP0008469_abnormal_protein_level0.51504010
132MP0009672_abnormal_birth_weight0.49338471
133MP0005319_abnormal_enzyme/_coenzyme0.48116487
134* MP0002723_abnormal_immune_serum0.46853313
135MP0000477_abnormal_intestine_morphology0.46808379

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.36403492
2Abnormality of cells of the erythroid lineage (HP:0012130)7.83103735
3* Poikilocytosis (HP:0004447)7.82224713
4* Reticulocytosis (HP:0001923)5.49084679
5Birth length less than 3rd percentile (HP:0003561)4.95126332
6Hyperthyroidism (HP:0000836)4.94573847
7* Abnormality of reticulocytes (HP:0004312)4.70304099
8* Petechiae (HP:0000967)4.62718705
9Abnormal hemoglobin (HP:0011902)4.55989602
10Hyperbilirubinemia (HP:0002904)4.53144551
11Diaphragmatic weakness (HP:0009113)4.50945755
12Truncus arteriosus (HP:0001660)4.30490814
13Hypertensive crisis (HP:0100735)4.02137188
14Increased mean platelet volume (HP:0011877)4.01453883
15Increased serum ferritin (HP:0003281)3.99902155
16Cholelithiasis (HP:0001081)3.69212023
17Seborrheic dermatitis (HP:0001051)3.64841251
18Aplastic anemia (HP:0001915)3.64295989
19Hypochromic microcytic anemia (HP:0004840)3.49778000
20Menorrhagia (HP:0000132)3.41950671
21* Acanthocytosis (HP:0001927)3.39075296
22Reticulocytopenia (HP:0001896)3.39003131
23* Pallor (HP:0000980)3.37058044
24Abnormality of iron homeostasis (HP:0011031)3.32838252
25Paralysis (HP:0003470)3.24884543
26Insomnia (HP:0100785)3.21286620
27Hypoparathyroidism (HP:0000829)3.20828556
28Abnormal gallbladder morphology (HP:0012437)3.19978949
29* Prolonged bleeding time (HP:0003010)3.17774942
30Hypochromic anemia (HP:0001931)3.16677608
31Abnormality of transition element cation homeostasis (HP:0011030)3.16334972
32Acute encephalopathy (HP:0006846)3.15846578
33Hepatocellular necrosis (HP:0001404)3.09220443
34Breast hypoplasia (HP:0003187)3.03917526
35Chronic obstructive pulmonary disease (HP:0006510)3.01832321
36Obstructive lung disease (HP:0006536)3.01832321
37Microcytic anemia (HP:0001935)2.97325445
38Acute necrotizing encephalopathy (HP:0006965)2.96371166
39Abnormal mitochondria in muscle tissue (HP:0008316)2.96006965
40Hepatic necrosis (HP:0002605)2.79954917
41* Cutaneous photosensitivity (HP:0000992)2.79926945
42Cholecystitis (HP:0001082)2.79620672
43Abnormal gallbladder physiology (HP:0012438)2.79620672
44Aplasia/Hypoplasia of the earlobes (HP:0009906)2.70951467
45Myelodysplasia (HP:0002863)2.67101875
46Upper limb muscle weakness (HP:0003484)2.65158119
47* Macrocytic anemia (HP:0001972)2.64289244
48Oral leukoplakia (HP:0002745)2.62825529
49Mitochondrial inheritance (HP:0001427)2.62139659
50Abnormality of the tricuspid valve (HP:0001702)2.59902095
51Cerebral hypomyelination (HP:0006808)2.58868893
52* Impaired platelet aggregation (HP:0003540)2.58709882
53* Abnormal platelet function (HP:0011869)2.58709882
54Atelectasis (HP:0100750)2.58689695
55Increased CSF lactate (HP:0002490)2.53446270
56Abnormal large intestine physiology (HP:0012700)2.52777934
57Bowel incontinence (HP:0002607)2.51218422
58Homocystinuria (HP:0002156)2.50642427
59Abnormality of homocysteine metabolism (HP:0010919)2.50642427
60Progressive muscle weakness (HP:0003323)2.47151063
61Ventricular fibrillation (HP:0001663)2.42866618
62Gingival bleeding (HP:0000225)2.42547436
63Progressive macrocephaly (HP:0004481)2.42445492
64* Epistaxis (HP:0000421)2.42159492
65Delusions (HP:0000746)2.41070894
66Pustule (HP:0200039)2.41057980
67Patellar aplasia (HP:0006443)2.39499600
68Secondary amenorrhea (HP:0000869)2.37698977
69Aplasia/Hypoplasia of the thymus (HP:0010515)2.37693871
70Microretrognathia (HP:0000308)2.34402566
71Bone marrow hypocellularity (HP:0005528)2.32629607
72Cerebral palsy (HP:0100021)2.32226686
73Rough bone trabeculation (HP:0100670)2.29750287
74Prominent nose (HP:0000448)2.28624684
75Chromsome breakage (HP:0040012)2.27624939
76Abnormality of the preputium (HP:0100587)2.27280981
77Ileus (HP:0002595)2.25640808
78Aplasia/Hypoplasia of the patella (HP:0006498)2.23506206
79Abnormality of chromosome stability (HP:0003220)2.20413189
80Abnormal spermatogenesis (HP:0008669)2.17278373
81Purpura (HP:0000979)2.15790972
82Abnormality of the gallbladder (HP:0005264)2.15427478
83Nausea (HP:0002018)2.13011580
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11777872
85Entropion (HP:0000621)2.11644076
86Abnormally folded helix (HP:0008544)2.11239678
87Carpal bone hypoplasia (HP:0001498)2.08899246
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08704586
89Orthostatic hypotension (HP:0001278)2.06355093
90Premature ovarian failure (HP:0008209)2.06158803
91Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03885710
92Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03885710
933-Methylglutaconic aciduria (HP:0003535)2.02972855
94Meckel diverticulum (HP:0002245)2.01067942
95Chronic otitis media (HP:0000389)2.00166267
96* Abnormality of the heme biosynthetic pathway (HP:0010472)12.3971291
97Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99589070
98Abnormality of cochlea (HP:0000375)1.95985127
99Spontaneous hematomas (HP:0007420)1.95712237
100Multiple enchondromatosis (HP:0005701)1.93817582
101Abnormality of the ileum (HP:0001549)1.93749878
102Absent thumb (HP:0009777)1.93236890
103Tinnitus (HP:0000360)1.93185743
104Cafe-au-lait spot (HP:0000957)1.92655189
105Tongue fasciculations (HP:0001308)1.91654929
106Cerebral edema (HP:0002181)1.91547050
107Hepatocellular carcinoma (HP:0001402)1.91160696
108Hyponatremia (HP:0002902)1.91091906
109Albinism (HP:0001022)1.90323724
110Pancytopenia (HP:0001876)1.89872161
111Increased serum lactate (HP:0002151)1.88273263
112Emotional lability (HP:0000712)1.87956207
113Duplicated collecting system (HP:0000081)1.87836711
114Irregular epiphyses (HP:0010582)1.87070943
115Azoospermia (HP:0000027)1.85166823
116Abnormality of lateral ventricle (HP:0030047)1.84544496
117Hypoplasia of the pons (HP:0012110)1.84066144
118Basal cell carcinoma (HP:0002671)1.83780068
119Global brain atrophy (HP:0002283)1.81680192
120IgM deficiency (HP:0002850)1.81365758
121Overfolded helix (HP:0000396)1.81257894
122Impulsivity (HP:0100710)1.80940552
123Reduced antithrombin III activity (HP:0001976)1.80896065
124Microvesicular hepatic steatosis (HP:0001414)1.80375262
125Acute myeloid leukemia (HP:0004808)1.79861216
126Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79024887
127Nonimmune hydrops fetalis (HP:0001790)1.77850962
128Respiratory difficulties (HP:0002880)1.76393404
129Gastrointestinal dysmotility (HP:0002579)1.76342610
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.75963322
131Venous insufficiency (HP:0005293)1.74553074
132Abnormality of the pons (HP:0007361)1.74316349
133Onycholysis (HP:0001806)1.74270642
134Abnormality of the renal collecting system (HP:0004742)1.73495074
135CNS hypomyelination (HP:0003429)1.73271457
136Hypopigmented skin patches (HP:0001053)1.72861275
137Lymphoma (HP:0002665)1.71931523
138Abnormality of the fingertips (HP:0001211)1.71868248
139Abnormal platelet volume (HP:0011876)1.70902250
140Personality changes (HP:0000751)1.69377498
141Abnormality of T cell physiology (HP:0011840)1.69301691
142Respiratory failure (HP:0002878)1.68585974
143Degeneration of anterior horn cells (HP:0002398)1.68190327
144Abnormality of the anterior horn cell (HP:0006802)1.68190327
145Deep palmar crease (HP:0006191)1.67835993
146Thrombocytosis (HP:0001894)1.67326010
147Increased density of long bones (HP:0006392)1.66038248
148Cortical visual impairment (HP:0100704)1.64321473
149Muscle fibrillation (HP:0010546)1.64313526
150Pendular nystagmus (HP:0012043)1.64088848
151Abnormality of the thymus (HP:0000777)1.63958161
152Squamous cell carcinoma (HP:0002860)1.63146781
153Hepatosplenomegaly (HP:0001433)1.62977413
154Visual hallucinations (HP:0002367)1.62487328
155CNS demyelination (HP:0007305)1.61429828
156Venous abnormality (HP:0002624)1.61115858
157* Polycythemia (HP:0001901)1.61085751
158Lactic acidosis (HP:0003128)1.61062020
159Type I transferrin isoform profile (HP:0003642)1.59099035
160Selective tooth agenesis (HP:0001592)1.58577420

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72337363
2EIF2AK14.69228571
3RIPK44.07776255
4CDC73.67084839
5WEE13.35056173
6PDK23.18473606
7ERN13.09457038
8NME23.03661471
9NEK22.77981062
10STK162.71286254
11DYRK32.55972422
12BRSK22.46482223
13BRSK12.20916458
14VRK12.19375573
15BMX2.13892192
16PIM22.05625865
17TLK11.92339983
18SCYL21.91800617
19STK41.86639725
20CDK191.84424673
21TAOK21.83222725
22MST41.81267651
23EEF2K1.77274857
24MAP3K101.75713939
25TEC1.75520488
26TTK1.61821868
27STK101.50188461
28PRPF4B1.49634738
29PLK11.47414585
30SRPK11.41784978
31NUAK11.41651826
32PIM11.40266033
33MKNK21.39653451
34ACVR1B1.37627779
35BMPR21.36721404
36KSR21.33857618
37AURKB1.32983118
38VRK21.32494626
39NEK11.32220114
40CDK41.32098996
41MAP3K111.31275565
42AURKA1.31055424
43KDR1.27231391
44MAP3K81.27033386
45TSSK61.26377116
46BCKDK1.25981005
47RPS6KA41.21575614
48MAP4K11.20330471
49ATR1.19750875
50CHEK21.19455997
51CDK71.18246704
52CCNB11.16300899
53MKNK11.15902104
54TAOK31.11516434
55TAOK11.06425765
56ZAK1.02470718
57MATK1.01245770
58MAPK110.97766472
59PLK40.97493053
60CHEK10.97390386
61MAPKAPK50.97151852
62MAP3K10.93666696
63IRAK30.91129988
64STK30.89642919
65MARK30.88695123
66RPS6KB20.87912847
67EPHA30.82069077
68TRPM70.80974883
69TYK20.80616650
70BRAF0.80309716
71LRRK20.79836790
72EIF2AK30.78074499
73ILK0.77382961
74JAK20.74301756
75RPS6KA50.72718177
76NTRK30.72177800
77ATM0.71935617
78CDK60.69992311
79CDK20.67854074
80PLK30.67153790
81TRIB30.67009937
82GRK60.66958331
83MAP3K20.63693776
84BLK0.63249218
85KIT0.61435340
86CSNK2A20.61119566
87TESK20.59967072
88RAF10.59704350
89FLT30.59571729
90DMPK0.59409525
91IKBKB0.59096927
92CDK80.56521573
93CLK10.56505040
94CDK10.55460110
95PKN20.54835263
96HCK0.54791385
97CDK120.53390194
98TNK20.53199268
99MAPK120.52638464
100ALK0.52634370
101RET0.52222010
102ABL20.50991525
103CSNK2A10.50714446
104AKT20.49949389
105PAK10.48390918
106RPS6KA60.48130453
107MAP3K60.47800487
108KSR10.47747459
109STK240.47746681
110IRAK40.47004631
111MAP2K10.43896770
112TBK10.43749035
113LYN0.43706955
114RPS6KC10.43074775
115RPS6KL10.43074775
116SIK20.42630705
117BTK0.42101272
118SYK0.41759983
119ZAP700.40469153
120MAP2K30.40183563
121NME10.39290120
122EPHB10.39104987
123PAK20.38097676
124FES0.37569561
125EIF2AK20.37456515
126JAK30.36447174
127DYRK1B0.35951144
128TNIK0.35808972
129PAK40.35463546
130MAP4K20.35003319
131* MAPK30.34970409
132RPS6KA10.34109581
133IKBKE0.34043698
134PTK2B0.33999746
135PRKD10.33888821
136MAPKAPK30.33888599

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.02892695
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.31190898
3Ribosome_Homo sapiens_hsa030103.66357429
4Mismatch repair_Homo sapiens_hsa034303.20512474
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.12087060
6Vitamin B6 metabolism_Homo sapiens_hsa007503.10755016
7RNA polymerase_Homo sapiens_hsa030202.98586574
8Spliceosome_Homo sapiens_hsa030402.98360797
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97388157
10Cell cycle_Homo sapiens_hsa041102.75812133
11Base excision repair_Homo sapiens_hsa034102.73238798
12Homologous recombination_Homo sapiens_hsa034402.62346535
13RNA transport_Homo sapiens_hsa030132.57265941
14Nucleotide excision repair_Homo sapiens_hsa034202.57069360
15Pyrimidine metabolism_Homo sapiens_hsa002402.48513575
16Proteasome_Homo sapiens_hsa030502.42461934
17Sulfur relay system_Homo sapiens_hsa041222.26157844
18Systemic lupus erythematosus_Homo sapiens_hsa053221.99932801
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90554027
20One carbon pool by folate_Homo sapiens_hsa006701.89010381
21Fanconi anemia pathway_Homo sapiens_hsa034601.86774073
22p53 signaling pathway_Homo sapiens_hsa041151.72852834
23Pentose phosphate pathway_Homo sapiens_hsa000301.68846155
24Basal transcription factors_Homo sapiens_hsa030221.67776556
25Nitrogen metabolism_Homo sapiens_hsa009101.59930485
26RNA degradation_Homo sapiens_hsa030181.59126752
27Non-homologous end-joining_Homo sapiens_hsa034501.53310092
28Folate biosynthesis_Homo sapiens_hsa007901.46595913
29Purine metabolism_Homo sapiens_hsa002301.44314231
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39774313
31Pyruvate metabolism_Homo sapiens_hsa006201.39418401
32mRNA surveillance pathway_Homo sapiens_hsa030151.33224613
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.19691975
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16502796
35Fatty acid elongation_Homo sapiens_hsa000621.10185489
36Hematopoietic cell lineage_Homo sapiens_hsa046401.04897185
37Herpes simplex infection_Homo sapiens_hsa051681.02234898
38Olfactory transduction_Homo sapiens_hsa047400.97338219
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93898167
40Viral carcinogenesis_Homo sapiens_hsa052030.92007887
41Alcoholism_Homo sapiens_hsa050340.90289887
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88458632
43Epstein-Barr virus infection_Homo sapiens_hsa051690.88413776
44Selenocompound metabolism_Homo sapiens_hsa004500.81359938
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81189816
46Biosynthesis of amino acids_Homo sapiens_hsa012300.79235411
47Parkinsons disease_Homo sapiens_hsa050120.78937523
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74839201
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.74414363
50Oocyte meiosis_Homo sapiens_hsa041140.73973732
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73406493
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73011076
53B cell receptor signaling pathway_Homo sapiens_hsa046620.71653111
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70601073
55Huntingtons disease_Homo sapiens_hsa050160.69387843
56Chronic myeloid leukemia_Homo sapiens_hsa052200.68860334
57Fatty acid metabolism_Homo sapiens_hsa012120.68378184
58Butanoate metabolism_Homo sapiens_hsa006500.67533043
59ABC transporters_Homo sapiens_hsa020100.66043065
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65267338
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64371271
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64049340
63Apoptosis_Homo sapiens_hsa042100.62074355
64Small cell lung cancer_Homo sapiens_hsa052220.58082758
65Antigen processing and presentation_Homo sapiens_hsa046120.56132159
66African trypanosomiasis_Homo sapiens_hsa051430.52619173
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52607198
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52342971
69Acute myeloid leukemia_Homo sapiens_hsa052210.51812501
70Hepatitis B_Homo sapiens_hsa051610.51740496
71Measles_Homo sapiens_hsa051620.51568579
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51182651
73HIF-1 signaling pathway_Homo sapiens_hsa040660.49231610
74Propanoate metabolism_Homo sapiens_hsa006400.49204350
75mTOR signaling pathway_Homo sapiens_hsa041500.48570829
76Carbon metabolism_Homo sapiens_hsa012000.45772233
77Caffeine metabolism_Homo sapiens_hsa002320.44192928
78Glutathione metabolism_Homo sapiens_hsa004800.44078731
79Steroid biosynthesis_Homo sapiens_hsa001000.43877834
80Shigellosis_Homo sapiens_hsa051310.43861140
81Thyroid cancer_Homo sapiens_hsa052160.43025115
82HTLV-I infection_Homo sapiens_hsa051660.41854120
83Bladder cancer_Homo sapiens_hsa052190.40624434
84Metabolic pathways_Homo sapiens_hsa011000.40317351
85Alzheimers disease_Homo sapiens_hsa050100.40031831
86Protein export_Homo sapiens_hsa030600.39798827
87Leishmaniasis_Homo sapiens_hsa051400.39613966
88Collecting duct acid secretion_Homo sapiens_hsa049660.39397298
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.38947013
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37824130
91Regulation of autophagy_Homo sapiens_hsa041400.36749134
92Non-small cell lung cancer_Homo sapiens_hsa052230.36741747
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36437935
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34588379
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33709673
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32198146
97Oxidative phosphorylation_Homo sapiens_hsa001900.32170644
98Malaria_Homo sapiens_hsa051440.31542874
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.31381481
100Other glycan degradation_Homo sapiens_hsa005110.30999668
101Sulfur metabolism_Homo sapiens_hsa009200.30997213
102Lysine degradation_Homo sapiens_hsa003100.29439398
103Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27869940
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27801241
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27007220
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26313160
107Arachidonic acid metabolism_Homo sapiens_hsa005900.26251995
108Legionellosis_Homo sapiens_hsa051340.26137496
109VEGF signaling pathway_Homo sapiens_hsa043700.26118182
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.26098168
111Primary immunodeficiency_Homo sapiens_hsa053400.25471827
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.25132989
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24756778
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24226951
115N-Glycan biosynthesis_Homo sapiens_hsa005100.22960861
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22508051
117Influenza A_Homo sapiens_hsa051640.22112729
118AMPK signaling pathway_Homo sapiens_hsa041520.18997421
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.18734300
120Pancreatic cancer_Homo sapiens_hsa052120.18363056
121Vitamin digestion and absorption_Homo sapiens_hsa049770.18301886
122Fructose and mannose metabolism_Homo sapiens_hsa000510.17453007
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16787777
124Platelet activation_Homo sapiens_hsa046110.16678437
125Galactose metabolism_Homo sapiens_hsa000520.16578174
126FoxO signaling pathway_Homo sapiens_hsa040680.16397469
127Asthma_Homo sapiens_hsa053100.13819592

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