GAS2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)3.96281970
2barbed-end actin filament capping (GO:0051016)3.93274075
3positive regulation of receptor recycling (GO:0001921)3.86348408
4cytoskeletal anchoring at plasma membrane (GO:0007016)3.83011733
5apoptotic cell clearance (GO:0043277)3.63967975
6adenosine receptor signaling pathway (GO:0001973)3.51545521
7protein localization to endosome (GO:0036010)3.51125171
8stress fiber assembly (GO:0043149)3.48314033
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.32462141
10regulation of early endosome to late endosome transport (GO:2000641)3.29732279
11low-density lipoprotein particle clearance (GO:0034383)3.27091941
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.14984176
13regulation of clathrin-mediated endocytosis (GO:2000369)3.14485793
14macroautophagy (GO:0016236)3.11107913
15angiogenesis involved in wound healing (GO:0060055)3.10283262
16positive regulation of protein dephosphorylation (GO:0035307)3.09549772
17synaptonemal complex assembly (GO:0007130)3.03533338
18platelet aggregation (GO:0070527)3.00253870
19regulation of hippo signaling (GO:0035330)2.99588130
20negative regulation of adherens junction organization (GO:1903392)2.98638098
21negative regulation of focal adhesion assembly (GO:0051895)2.98638098
22negative regulation of cell junction assembly (GO:1901889)2.98638098
23basement membrane organization (GO:0071711)2.93739135
24plasma membrane repair (GO:0001778)2.91509612
25skin morphogenesis (GO:0043589)2.90092531
26cell-substrate junction assembly (GO:0007044)2.89955043
27synaptonemal complex organization (GO:0070193)2.89338800
28cell-cell junction maintenance (GO:0045217)2.85735177
29sodium ion export (GO:0071436)2.85374894
30fusion of sperm to egg plasma membrane (GO:0007342)2.84290235
31epithelial cell-cell adhesion (GO:0090136)2.84256855
32desmosome organization (GO:0002934)2.80659709
33Golgi transport vesicle coating (GO:0048200)2.79652225
34COPI coating of Golgi vesicle (GO:0048205)2.79652225
35G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78517730
36negative regulation of homotypic cell-cell adhesion (GO:0034111)2.78197254
37regulation of p38MAPK cascade (GO:1900744)2.77136681
38protein heterotrimerization (GO:0070208)2.75960207
39glomerular basement membrane development (GO:0032836)2.75499923
40positive regulation of blood vessel endothelial cell migration (GO:0043536)2.74915447
41atrioventricular valve morphogenesis (GO:0003181)2.74804601
42regulation of extracellular matrix disassembly (GO:0010715)2.74790172
43negative regulation of fatty acid transport (GO:2000192)2.73693987
44protein retention in ER lumen (GO:0006621)2.72564135
45regulation of integrin-mediated signaling pathway (GO:2001044)2.71974901
46layer formation in cerebral cortex (GO:0021819)2.70966376
47extracellular fibril organization (GO:0043206)2.69714138
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67973791
49cell adhesion mediated by integrin (GO:0033627)2.66459319
50piRNA metabolic process (GO:0034587)2.66215068
51ovulation cycle (GO:0042698)2.65634803
52endocytic recycling (GO:0032456)2.64473312
53positive regulation of endothelial cell apoptotic process (GO:2000353)2.64266697
54positive regulation of Cdc42 GTPase activity (GO:0043089)2.63229646
55positive regulation of male gonad development (GO:2000020)2.63135655
56endothelial cell chemotaxis (GO:0035767)2.62968493
57negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.61068568
58ectoderm development (GO:0007398)2.60655776
59mannose metabolic process (GO:0006013)2.58657492
60regulation of tight junction assembly (GO:2000810)2.57782224
61response to magnesium ion (GO:0032026)2.56404647
62positive regulation of osteoblast proliferation (GO:0033690)2.55601311
63cell volume homeostasis (GO:0006884)2.54773981
64vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54409583
65adherens junction assembly (GO:0034333)2.52511505
66Rho protein signal transduction (GO:0007266)2.49910595
67fibril organization (GO:0097435)2.49523407
68cellular response to interferon-alpha (GO:0035457)2.48648026
69protein targeting to plasma membrane (GO:0072661)2.48063528
70maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.47720476
71glutamate secretion (GO:0014047)2.47547572
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.46868658
73establishment of apical/basal cell polarity (GO:0035089)2.46444731
74retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46404758
75actin filament bundle organization (GO:0061572)2.44458620
76actin filament bundle assembly (GO:0051017)2.44458620
77signal complex assembly (GO:0007172)2.42901001
78apoptotic process involved in morphogenesis (GO:0060561)2.42845897
79plasma membrane fusion (GO:0045026)2.42667342
80platelet degranulation (GO:0002576)2.41404296
81negative regulation of catenin import into nucleus (GO:0035414)2.41041545
82regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.39960020
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.38624333
84sex determination (GO:0007530)2.37885930
85endodermal cell differentiation (GO:0035987)2.37803037
86negative regulation of protein localization to plasma membrane (GO:1903077)2.37748074
87regulation of cholesterol storage (GO:0010885)2.35718761
88growth hormone secretion (GO:0030252)2.35030617
89positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.33997064
90activation of protein kinase A activity (GO:0034199)2.33612642
91positive regulation of p38MAPK cascade (GO:1900745)2.32132862
92regulation of cholesterol homeostasis (GO:2000188)2.32126472
93axon extension involved in axon guidance (GO:0048846)2.31920737
94neuron projection extension involved in neuron projection guidance (GO:1902284)2.31920737
95regulation of protein dephosphorylation (GO:0035304)2.31699601
96anatomical structure regression (GO:0060033)2.30910517
97positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.30511034
98hippo signaling (GO:0035329)2.30342953
99adhesion of symbiont to host (GO:0044406)2.29487809
100regulation of male gonad development (GO:2000018)2.29233312
101positive regulation of extracellular matrix organization (GO:1903055)2.28728288
102cortical actin cytoskeleton organization (GO:0030866)2.28536835
103wound healing, spreading of epidermal cells (GO:0035313)2.27732463
104positive regulation of axon extension (GO:0045773)2.27232729
105establishment of protein localization to plasma membrane (GO:0090002)2.27025828
106ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.26365021
107peptidyl-proline hydroxylation (GO:0019511)2.26171641
108actin filament capping (GO:0051693)2.25907706
109negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.24461364
110regulation of ARF GTPase activity (GO:0032312)2.22979875
111modulation by symbiont of host cellular process (GO:0044068)2.22940683
112modulation by virus of host morphology or physiology (GO:0019048)2.22591279
113cerebellar granule cell differentiation (GO:0021707)2.22529238
114hyaluronan catabolic process (GO:0030214)2.21895615
115fibroblast migration (GO:0010761)2.21875675
116regulation of water loss via skin (GO:0033561)2.21849715
117regulation of receptor recycling (GO:0001919)2.21822916
118decidualization (GO:0046697)2.21751874
119myelin maintenance (GO:0043217)2.21353488
120protein maturation by protein folding (GO:0022417)2.21322033
121vesicle targeting (GO:0006903)2.20950944
122glial cell proliferation (GO:0014009)2.20722400
123polarized epithelial cell differentiation (GO:0030859)2.20409704
124extracellular matrix assembly (GO:0085029)2.19961268
125regulation of leukocyte degranulation (GO:0043300)2.19777486
126regulation of platelet aggregation (GO:0090330)2.19655984
127regulation of ARF protein signal transduction (GO:0032012)2.19230997
128positive regulation of cellular amide metabolic process (GO:0034250)2.18150199
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.17424812
130establishment of monopolar cell polarity (GO:0061162)2.17424812
131regulation of mammary gland epithelial cell proliferation (GO:0033599)2.17056585
132activation of JUN kinase activity (GO:0007257)2.17045969
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.17040376
134negative regulation of cell size (GO:0045792)2.16834525
135response to acidic pH (GO:0010447)2.16148495
136positive regulation of vesicle fusion (GO:0031340)2.15972940
137cell-substrate adherens junction assembly (GO:0007045)2.15501598
138focal adhesion assembly (GO:0048041)2.15501598
139labyrinthine layer blood vessel development (GO:0060716)2.15078732
140positive regulation of fibroblast migration (GO:0010763)2.14117919
141synaptic vesicle exocytosis (GO:0016079)2.13797485
142establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.11470488
143regulation of glomerular filtration (GO:0003093)2.10641683
144regulation of NFAT protein import into nucleus (GO:0051532)2.10471669
145regulation of integrin activation (GO:0033623)2.10135601
146activation of Rac GTPase activity (GO:0032863)2.08814365
147gonadal mesoderm development (GO:0007506)2.07557851
148regulation of SMAD protein import into nucleus (GO:0060390)2.07060939
149activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.05331245
150extracellular matrix disassembly (GO:0022617)2.05198973
151hypotonic response (GO:0006971)2.03925988
152semaphorin-plexin signaling pathway (GO:0071526)2.02611493
153membrane budding (GO:0006900)2.01413754
154response to laminar fluid shear stress (GO:0034616)2.01402844
155bundle of His cell to Purkinje myocyte communication (GO:0086069)2.00966713
156regulation of meiosis I (GO:0060631)1.98853738
157substrate adhesion-dependent cell spreading (GO:0034446)1.98022250
158renal system process involved in regulation of blood volume (GO:0001977)1.97957937
159regulation of transforming growth factor beta1 production (GO:0032908)1.97830129
160collagen fibril organization (GO:0030199)1.97733885
161regulation of fatty acid beta-oxidation (GO:0031998)1.97562919
162lymphangiogenesis (GO:0001946)1.97508322
163synaptic vesicle docking involved in exocytosis (GO:0016081)1.97483657
164endothelial cell morphogenesis (GO:0001886)1.97394024
165protein insertion into membrane (GO:0051205)1.97144651
166negative regulation of organic acid transport (GO:0032891)1.96964696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.90994547
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.11214901
3TRIM28_21343339_ChIP-Seq_HEK293_Human2.93992984
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.62382964
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58613069
6ZNF263_19887448_ChIP-Seq_K562_Human2.36538565
7NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08107225
8KDM2B_26808549_Chip-Seq_K562_Human2.04561915
9ESR2_21235772_ChIP-Seq_MCF-7_Human1.91920135
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91671433
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89753577
12ERG_21242973_ChIP-ChIP_JURKAT_Human1.86861000
13LXR_22292898_ChIP-Seq_THP-1_Human1.86552210
14VDR_21846776_ChIP-Seq_THP-1_Human1.86220968
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84413136
16KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79226648
17RACK7_27058665_Chip-Seq_MCF-7_Human1.78467842
18CLOCK_20551151_ChIP-Seq_293T_Human1.74760244
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71682455
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67696713
21MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60432527
22P68_20966046_ChIP-Seq_HELA_Human1.57452220
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.56791792
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55153115
25* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51496343
26WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50874553
27KDM2B_26808549_Chip-Seq_DND41_Human1.50643445
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50538599
29* TET1_21451524_ChIP-Seq_MESCs_Mouse1.49975754
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42188693
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40029741
32RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39915441
33* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39725835
34GATA1_19941826_ChIP-Seq_K562_Human1.38112325
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34574809
36MYC_22102868_ChIP-Seq_BL_Human1.34394395
37ATF3_27146783_Chip-Seq_COLON_Human1.34200552
38TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34063795
39HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33824517
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33000758
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32546492
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31251993
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.30128674
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.30128674
45* GATA1_19941827_ChIP-Seq_MEL_Mouse1.29867665
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27891869
47CREB1_26743006_Chip-Seq_LNCaP_Human1.27052031
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.26808531
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.26604150
50* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25523896
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.25074871
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24994732
53SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24600321
54SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23385213
55* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22665807
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22153735
57* RUNX1_22412390_ChIP-Seq_EML_Mouse1.21735559
58VDR_24763502_ChIP-Seq_THP-1_Human1.21600508
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.21497573
60TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21404751
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21343896
62* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20694710
63TP53_22127205_ChIP-Seq_IMR90_Human1.19756261
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18889891
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18604896
66DROSHA_22980978_ChIP-Seq_HELA_Human1.17616285
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17195005
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15072587
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14643429
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.14229577
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.14229577
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.14229577
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12176961
74* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10792470
75* BCOR_27268052_Chip-Seq_Bcells_Human1.10769902
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10580246
77ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10449832
78* KLF5_25053715_ChIP-Seq_YYC3_Human1.09773800
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09707704
80* NCOR1_26117541_ChIP-Seq_K562_Human1.09435727
81JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08266792
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.08153432
83SCL_19346495_ChIP-Seq_HPC-7_Human1.08143157
84CTCF_27219007_Chip-Seq_Bcells_Human1.07570084
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.07522735
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05765257
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.05679473
88SMC4_20622854_ChIP-Seq_HELA_Human1.05510221
89RNF2_27304074_Chip-Seq_ESCs_Mouse1.05193501
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04642934
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04604616
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04101552
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03899377
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03689916
95* RARB_27405468_Chip-Seq_BRAIN_Mouse1.03568858
96SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03187951
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02781417
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.02315922
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02225270
100TP63_22573176_ChIP-Seq_HFKS_Human1.01763530
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01600526
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01596427
103UBF1/2_26484160_Chip-Seq_HMECs_Human1.01489431
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.01094761
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00139053
106EZH2_27294783_Chip-Seq_ESCs_Mouse0.99939610
107TP53_23651856_ChIP-Seq_MEFs_Mouse0.99274989
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.99232049
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98923271
110BCL6_27268052_Chip-Seq_Bcells_Human0.98862509
111* RXR_22158963_ChIP-Seq_LIVER_Mouse0.98687961
112MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97917923
113* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97883795
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96837694
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96629726
116WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96257548
117TCF7_22412390_ChIP-Seq_EML_Mouse0.95614304
118SPI1_23127762_ChIP-Seq_K562_Human0.95332457
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95205563
120JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95194371
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95180769
122SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94913428
123SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94866256
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94223650
125AHR_22903824_ChIP-Seq_MCF-7_Human0.93426348
126LXR_22158963_ChIP-Seq_LIVER_Mouse0.92964388
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91603791
128* ELF1_20517297_ChIP-Seq_JURKAT_Human0.90223039
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90103238
130SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90080816
131TBX20_22080862_ChIP-Seq_HEART_Mouse0.89876179
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.89876179
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.89855932
134TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89582124
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88169417
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87200607
137KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.86503419

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog5.08439302
2MP0008438_abnormal_cutaneous_collagen3.25391962
3MP0004858_abnormal_nervous_system3.18119472
4MP0005377_hearing/vestibular/ear_phenot3.03169135
5MP0003878_abnormal_ear_physiology3.03169135
6MP0005275_abnormal_skin_tensile3.02794232
7MP0005623_abnormal_meninges_morphology2.93075323
8MP0004272_abnormal_basement_membrane2.76015075
9MP0010234_abnormal_vibrissa_follicle2.75919979
10MP0005464_abnormal_platelet_physiology2.74266191
11MP0002796_impaired_skin_barrier2.54112488
12MP0005409_darkened_coat_color2.44844306
13MP0002254_reproductive_system_inflammat2.33031745
14MP0004859_abnormal_synaptic_plasticity2.28964241
15MP0003566_abnormal_cell_adhesion2.13735869
16MP0008260_abnormal_autophagy2.10966589
17MP0005076_abnormal_cell_differentiation2.00628311
18MP0003172_abnormal_lysosome_physiology1.98586783
19MP0001958_emphysema1.95607028
20MP0003283_abnormal_digestive_organ1.93984672
21MP0010352_gastrointestinal_tract_polyps1.88016364
22MP0003879_abnormal_hair_cell1.81852578
23MP0005410_abnormal_fertilization1.80534721
24MP0003091_abnormal_cell_migration1.74019919
25MP0003045_fibrosis1.68260556
26MP0009780_abnormal_chondrocyte_physiolo1.64928496
27MP0008995_early_reproductive_senescence1.58827603
28MP0003453_abnormal_keratinocyte_physiol1.52499208
29MP0005451_abnormal_body_composition1.50697405
30MP0004185_abnormal_adipocyte_glucose1.48063613
31MP0000013_abnormal_adipose_tissue1.44114753
32MP0002060_abnormal_skin_morphology1.42338498
33MP0000343_altered_response_to1.42040873
34MP0002295_abnormal_pulmonary_circulatio1.40383505
35MP0002653_abnormal_ependyma_morphology1.35320291
36MP0003300_gastrointestinal_ulcer1.33877142
37MP0001849_ear_inflammation1.33862740
38MP0000003_abnormal_adipose_tissue1.33675696
39MP0000751_myopathy1.33607372
40MP0009840_abnormal_foam_cell1.33302586
41MP0000858_altered_metastatic_potential1.31997803
42MP0008961_abnormal_basal_metabolism1.31807057
43MP0000534_abnormal_ureter_morphology1.30916055
44MP0002896_abnormal_bone_mineralization1.30177243
45MP0000467_abnormal_esophagus_morphology1.28401036
46MP0005023_abnormal_wound_healing1.27291285
47MP0000678_abnormal_parathyroid_gland1.26958115
48MP0005167_abnormal_blood-brain_barrier1.25548459
49MP0005501_abnormal_skin_physiology1.22088835
50MP0005375_adipose_tissue_phenotype1.19889401
51MP0004885_abnormal_endolymph1.19774309
52MP0003329_amyloid_beta_deposits1.19691072
53MP0005595_abnormal_vascular_smooth1.18743080
54MP0002998_abnormal_bone_remodeling1.18004787
55MP0005058_abnormal_lysosome_morphology1.17709803
56MP0001348_abnormal_lacrimal_gland1.16928166
57MP0003183_abnormal_peptide_metabolism1.16888122
58MP0005670_abnormal_white_adipose1.15863350
59MP0010030_abnormal_orbit_morphology1.15698791
60MP0003279_aneurysm1.13449059
61MP0003941_abnormal_skin_development1.12504930
62MP0003191_abnormal_cellular_cholesterol1.11842080
63MP0009384_cardiac_valve_regurgitation1.11718353
64MP0005165_increased_susceptibility_to1.11006804
65MP0003436_decreased_susceptibility_to1.10001813
66MP0003828_pulmonary_edema1.08716319
67MP0008874_decreased_physiological_sensi1.08072847
68MP0000537_abnormal_urethra_morphology1.07702791
69MP0004510_myositis1.06179645
70MP0000750_abnormal_muscle_regeneration1.05091299
71MP0001533_abnormal_skeleton_physiology1.03609824
72MP0005257_abnormal_intraocular_pressure1.02632932
73MP0010771_integument_phenotype1.00129047
74MP0009053_abnormal_anal_canal0.99053396
75MP0003385_abnormal_body_wall0.98071349
76MP0003075_altered_response_to0.97769253
77MP0002877_abnormal_melanocyte_morpholog0.96133280
78MP0000920_abnormal_myelination0.95900463
79MP0005666_abnormal_adipose_tissue0.95487382
80MP0005166_decreased_susceptibility_to0.93243778
81MP0000249_abnormal_blood_vessel0.92220714
82MP0003115_abnormal_respiratory_system0.91809638
83MP0003942_abnormal_urinary_system0.91575670
84MP0003303_peritoneal_inflammation0.91094401
85MP0002168_other_aberrant_phenotype0.90886084
86MP0006138_congestive_heart_failure0.90213215
87MP0001440_abnormal_grooming_behavior0.90199182
88MP0004947_skin_inflammation0.89536169
89MP0000733_abnormal_muscle_development0.88261958
90MP0005083_abnormal_biliary_tract0.86610339
91MP0005390_skeleton_phenotype0.86297278
92MP0010368_abnormal_lymphatic_system0.85761425
93MP0003448_altered_tumor_morphology0.85031917
94MP0002249_abnormal_larynx_morphology0.84288270
95MP0004233_abnormal_muscle_weight0.83978879
96MP0001216_abnormal_epidermal_layer0.83629056
97MP0002909_abnormal_adrenal_gland0.83397900
98MP0005508_abnormal_skeleton_morphology0.83153400
99MP0000747_muscle_weakness0.81076794
100MP0002282_abnormal_trachea_morphology0.78639388
101MP0004270_analgesia0.78236954
102MP0001542_abnormal_bone_strength0.77537609
103MP0005503_abnormal_tendon_morphology0.76651257
104MP0000465_gastrointestinal_hemorrhage0.76203912
105MP0003119_abnormal_digestive_system0.74933577
106MP0008569_lethality_at_weaning0.74243397
107MP0004130_abnormal_muscle_cell0.74163662
108MP0005621_abnormal_cell_physiology0.71857340
109MP0000604_amyloidosis0.71853784
110MP0003795_abnormal_bone_structure0.70862762
111MP0003690_abnormal_glial_cell0.67981312
112MP0003195_calcinosis0.66267369
113MP0009278_abnormal_bone_marrow0.66005523
114MP0005164_abnormal_response_to0.65823827
115MP0001299_abnormal_eye_distance/0.65334244
116MP0003635_abnormal_synaptic_transmissio0.64685024
117MP0001851_eye_inflammation0.64210590
118MP0004381_abnormal_hair_follicle0.63496788
119MP0004087_abnormal_muscle_fiber0.62952033
120MP0002089_abnormal_postnatal_growth/wei0.62546063
121MP0003656_abnormal_erythrocyte_physiolo0.62345339
122MP0000767_abnormal_smooth_muscle0.62339094
123MP0008004_abnormal_stomach_pH0.61452803
124MP0000516_abnormal_urinary_system0.60341573
125MP0005367_renal/urinary_system_phenotyp0.60341573
126MP0009931_abnormal_skin_appearance0.59103998
127MP0010678_abnormal_skin_adnexa0.58757778
128MP0001243_abnormal_dermal_layer0.57975727
129MP0000579_abnormal_nail_morphology0.57593218
130MP0000428_abnormal_craniofacial_morphol0.57414754
131MP0003634_abnormal_glial_cell0.57396380

Predicted human phenotypes

RankGene SetZ-score
1Distal upper limb amyotrophy (HP:0007149)4.19887405
2Upper limb amyotrophy (HP:0009129)4.19887405
3Premature rupture of membranes (HP:0001788)4.07177006
4Hand muscle atrophy (HP:0009130)3.93631233
5Increased mean platelet volume (HP:0011877)3.78114964
6Protrusio acetabuli (HP:0003179)3.74237675
7Cerebral aneurysm (HP:0004944)3.71711341
8Menorrhagia (HP:0000132)3.61791915
9Abnormal platelet volume (HP:0011876)3.57712801
10Obstructive sleep apnea (HP:0002870)3.47577261
11Purpura (HP:0000979)3.39609450
12Prolonged bleeding time (HP:0003010)3.32187089
13Atrophic scars (HP:0001075)3.28228316
14Male infertility (HP:0003251)3.18920614
15Difficulty climbing stairs (HP:0003551)3.07663108
16Distal lower limb muscle weakness (HP:0009053)3.02141990
17Ankle contracture (HP:0006466)3.00582255
18Shallow orbits (HP:0000586)3.00210950
19Petechiae (HP:0000967)2.94945571
20Fragile skin (HP:0001030)2.88780960
21Increased connective tissue (HP:0009025)2.81607097
22Broad face (HP:0000283)2.78394151
23Vertebral compression fractures (HP:0002953)2.76898697
24Achilles tendon contracture (HP:0001771)2.70772370
25Dysostosis multiplex (HP:0000943)2.65429690
26Neurofibrillary tangles (HP:0002185)2.62184462
27Myokymia (HP:0002411)2.60484226
28Right ventricular cardiomyopathy (HP:0011663)2.58586650
29Bladder diverticulum (HP:0000015)2.53237663
30Cervical subluxation (HP:0003308)2.52684812
31Abnormality of the Achilles tendon (HP:0005109)2.50996267
32Hypercortisolism (HP:0001578)2.50333514
33Mildly elevated creatine phosphokinase (HP:0008180)2.49784247
34Polycythemia (HP:0001901)2.49634293
35Milia (HP:0001056)2.49096956
36Abnormality of the lower motor neuron (HP:0002366)2.45886466
37Facial diplegia (HP:0001349)2.43785398
38Alopecia of scalp (HP:0002293)2.40151947
39Hyporeflexia of lower limbs (HP:0002600)2.39681227
40Mitral valve prolapse (HP:0001634)2.36289072
41Epistaxis (HP:0000421)2.34840107
42Bronchomalacia (HP:0002780)2.34766073
43Peritonitis (HP:0002586)2.34522246
44Dilatation of the ascending aorta (HP:0005111)2.33505920
45Fragile nails (HP:0001808)2.31990808
46Hypoventilation (HP:0002791)2.31756929
47Thin bony cortex (HP:0002753)2.31344490
48Turricephaly (HP:0000262)2.27618686
49Increased variability in muscle fiber diameter (HP:0003557)2.25960785
50Aortic dissection (HP:0002647)2.22579204
51Short nail (HP:0001799)2.21388094
52Genu recurvatum (HP:0002816)2.19468344
53Nuclear cataract (HP:0100018)2.19042107
54Ankle clonus (HP:0011448)2.18496208
55Hyperparathyroidism (HP:0000843)2.15835648
56Mitral regurgitation (HP:0001653)2.13159387
57Abnormal platelet function (HP:0011869)2.13001942
58Impaired platelet aggregation (HP:0003540)2.13001942
59Abnormality of liposaccharide metabolism (HP:0010968)2.12879367
60Abnormality of glycosphingolipid metabolism (HP:0004343)2.12879367
61Abnormality of glycolipid metabolism (HP:0010969)2.12879367
62Spinal rigidity (HP:0003306)2.11770597
63Diaphragmatic weakness (HP:0009113)2.11254495
64Blue sclerae (HP:0000592)2.10951299
65J-shaped sella turcica (HP:0002680)2.10296684
66Rectal prolapse (HP:0002035)2.09343135
67Aneurysm (HP:0002617)2.09151731
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07043710
69Abnormality of polysaccharide metabolism (HP:0011012)2.07043710
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07043710
71Mucopolysacchariduria (HP:0008155)2.06112062
72Urinary glycosaminoglycan excretion (HP:0003541)2.06112062
73Aplasia involving bones of the extremities (HP:0009825)2.03863651
74Aplasia involving bones of the upper limbs (HP:0009823)2.03863651
75Aplasia of the phalanges of the hand (HP:0009802)2.03863651
76Stridor (HP:0010307)2.01752312
77Myocardial infarction (HP:0001658)1.99399527
78Abnormality of dentin (HP:0010299)1.97808495
79Mesangial abnormality (HP:0001966)1.94885225
80Metaphyseal cupping (HP:0003021)1.94738647
81Cerebral inclusion bodies (HP:0100314)1.94533124
82Supranuclear gaze palsy (HP:0000605)1.94391081
83Aortic aneurysm (HP:0004942)1.93744750
84Generalized amyotrophy (HP:0003700)1.91459141
85Insomnia (HP:0100785)1.91254346
86Lower limb amyotrophy (HP:0007210)1.91018121
87Arterial tortuosity (HP:0005116)1.90190418
88Hyperacusis (HP:0010780)1.89761815
89Abnormality of the musculature of the hand (HP:0001421)1.89324083
90Lymphangioma (HP:0100764)1.87349867
91Disproportionate tall stature (HP:0001519)1.86421806
92Abnormality of the distal phalanges of the toes (HP:0010182)1.84496491
93Increased cerebral lipofuscin (HP:0011813)1.84129457
94Hypertriglyceridemia (HP:0002155)1.83308496
95Plantar hyperkeratosis (HP:0007556)1.83206700
96Hyperextensible skin (HP:0000974)1.82471083
97Broad metatarsal (HP:0001783)1.81219609
98Distal lower limb amyotrophy (HP:0008944)1.80826175
99Abnormality of skeletal muscle fiber size (HP:0012084)1.80287364
100Hemorrhage of the eye (HP:0011885)1.79915673
101Difficulty running (HP:0009046)1.79628358
102Type 1 muscle fiber predominance (HP:0003803)1.79596230
103Neuronal loss in central nervous system (HP:0002529)1.77250258
104Myopathic facies (HP:0002058)1.76226918
105Joint stiffness (HP:0001387)1.75981831
106Acanthosis nigricans (HP:0000956)1.75979361
107Bruising susceptibility (HP:0000978)1.75528776
108Increased CSF protein (HP:0002922)1.74583253
109Slender build (HP:0001533)1.73895586
110Spontaneous hematomas (HP:0007420)1.73619370
111Wormian bones (HP:0002645)1.72574977
112Focal segmental glomerulosclerosis (HP:0000097)1.72162574
113Osteolytic defects of the hand bones (HP:0009699)1.70355219
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.70355219
115Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.70019848
116Loss of speech (HP:0002371)1.70000872
117Rapidly progressive (HP:0003678)1.68272652
118Peripheral hypomyelination (HP:0007182)1.67641737
119Spinal cord compression (HP:0002176)1.67480223
120Hyperthyroidism (HP:0000836)1.67213518
121Neonatal short-limb short stature (HP:0008921)1.65614166
122Buphthalmos (HP:0000557)1.64568441
123Fasciculations (HP:0002380)1.64197472
124Bulbar palsy (HP:0001283)1.63716333
125Bowel diverticulosis (HP:0005222)1.63654720
126Axonal loss (HP:0003447)1.63179587
127Deviation of the hallux (HP:0010051)1.62974408
128Action tremor (HP:0002345)1.62874860
129Follicular hyperkeratosis (HP:0007502)1.61587165
130Testicular neoplasm (HP:0010788)1.61488564
131Long toe (HP:0010511)1.60833139
132Gastrointestinal dysmotility (HP:0002579)1.60759744
133Thick nail (HP:0001805)1.58556824
134Thin ribs (HP:0000883)1.58298255
135Ulnar bowing (HP:0003031)1.58061728
136Biconcave vertebral bodies (HP:0004586)1.57838914
137Elbow flexion contracture (HP:0002987)1.57736964
138Easy fatigability (HP:0003388)1.57710563
139Gingival bleeding (HP:0000225)1.57409551
140Overgrowth (HP:0001548)1.57203346
141Back pain (HP:0003418)1.56908373
142Bone pain (HP:0002653)1.56667061
143Abnormal gallbladder physiology (HP:0012438)1.56433956
144Polygenic inheritance (HP:0010982)1.56281141
145Tetraparesis (HP:0002273)1.56081875
146Hallux valgus (HP:0001822)1.55703207
147Flat acetabular roof (HP:0003180)1.54698536
148Global brain atrophy (HP:0002283)1.53112348
149Muscle fibrillation (HP:0010546)1.52551330
150Stroke (HP:0001297)1.52295578
151Striae distensae (HP:0001065)1.51539008
152Vascular tortuosity (HP:0004948)1.51406693
153Venous abnormality (HP:0002624)1.51376769
154Palmoplantar hyperkeratosis (HP:0000972)1.51371468

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.46947500
2RIPK13.03492041
3PRKD33.03096870
4PRPF4B2.73284363
5IRAK32.44296744
6LATS22.32871182
7ICK2.27639971
8ERN12.21570931
9MAP3K92.19681869
10TYRO32.10764576
11PKN22.09717986
12BMX2.06099940
13DDR21.96082835
14TAOK21.91430505
15MAP3K21.88629520
16TESK11.88325403
17KSR21.87735850
18MAP2K31.77736314
19PDGFRA1.74638882
20TAOK11.72769670
21SMG11.70859220
22PTK2B1.70683901
23EPHA21.70374500
24PTK61.70012065
25DAPK21.61132822
26PTK21.59858267
27MAP2K21.56974420
28LMTK21.54881157
29TTN1.50442737
30NTRK11.49352821
31NME21.44382454
32FER1.43293929
33MST1R1.41571313
34PAK61.38209317
35MYLK1.37773392
36CDK121.36171133
37EPHB21.35713058
38MAP3K61.35501378
39ARAF1.30975268
40MAP3K31.30288117
41EEF2K1.21971603
42MAP2K11.18326537
43NTRK31.14878180
44MAPKAPK31.12820400
45MAP3K111.12592948
46EPHB11.11530650
47MARK21.10631329
48MET1.09494110
49PAK21.07917386
50DMPK1.07340058
51STK381.06015413
52EPHA41.02587318
53CAMKK11.02217848
54LATS11.01795680
55RET1.01655740
56RPS6KA21.01324170
57WNK11.01250935
58PAK31.00705596
59TNK20.93808941
60PAK40.93794448
61MAP3K100.91479241
62MOS0.90865260
63MTOR0.89266574
64PDPK10.89171872
65MAP3K10.88273354
66TESK20.85961968
67MAP3K130.85912527
68DAPK30.83162100
69LIMK10.82204579
70ZAP700.80276338
71MINK10.78125805
72SIK10.77165633
73PDK20.76775335
74IRAK20.76709135
75CDC42BPA0.76328176
76MAPK150.74411703
77ALK0.74287866
78PIM20.74109139
79DYRK1B0.73263755
80SCYL20.72091694
81GRK50.71720441
82BRAF0.71218995
83CAMK1G0.69975646
84PDK40.68445333
85PDK30.68445333
86ILK0.67931359
87MAPK120.66731206
88PRKD20.66207881
89STK110.64473097
90ROCK10.62401987
91CAMK2G0.60668656
92CAMK1D0.58764215
93ROCK20.57218320
94LRRK20.57068366
95SIK30.56880004
96RIPK40.53076251
97PRKG20.52747993
98MAP2K40.51909307
99FGR0.51476960
100RPS6KL10.50316380
101RPS6KC10.50316380
102TBK10.50088434
103MAP3K70.49917136
104HIPK20.48726966
105WNK40.48532435
106CAMK2B0.46132431
107KDR0.45489295
108MAP3K80.44997825
109SIK20.44452534
110PAK10.44381626
111FGFR10.44224063
112PRKCH0.44166371
113EIF2AK10.43238705
114PDGFRB0.42317547
115PDK10.41289486
116DAPK10.40500405
117PRKD10.39666053
118CDK50.39423912
119GSK3A0.39177324
120MAP3K40.38920256
121SGK30.38893283
122ABL20.38715942
123TGFBR20.37381709
124RPS6KA10.36105137
125FGFR40.35712843
126CSK0.35663269
127STK30.34532780
128ERBB20.34415853
129GRK60.33286030
130PHKG20.32368356
131CDK140.31820844

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.04435227
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97669635
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95969525
4Other glycan degradation_Homo sapiens_hsa005111.86977519
5Dorso-ventral axis formation_Homo sapiens_hsa043201.81080471
6ECM-receptor interaction_Homo sapiens_hsa045121.72896465
7Amoebiasis_Homo sapiens_hsa051461.65793893
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62613043
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59218398
10Platelet activation_Homo sapiens_hsa046111.55928226
11Notch signaling pathway_Homo sapiens_hsa043301.53069898
12Nitrogen metabolism_Homo sapiens_hsa009101.52186942
13Focal adhesion_Homo sapiens_hsa045101.45803979
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40768135
15Olfactory transduction_Homo sapiens_hsa047401.38727305
16Estrogen signaling pathway_Homo sapiens_hsa049151.34877042
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29132119
18Gastric acid secretion_Homo sapiens_hsa049711.28208696
19Glioma_Homo sapiens_hsa052141.25553326
20Synaptic vesicle cycle_Homo sapiens_hsa047211.25162514
21Proteoglycans in cancer_Homo sapiens_hsa052051.22824868
22Bladder cancer_Homo sapiens_hsa052191.22360490
23VEGF signaling pathway_Homo sapiens_hsa043701.21420026
24Bile secretion_Homo sapiens_hsa049761.20880999
25Mineral absorption_Homo sapiens_hsa049781.20432694
26Protein digestion and absorption_Homo sapiens_hsa049741.19108055
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17987773
28Tight junction_Homo sapiens_hsa045301.17104700
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17061518
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16446141
31GnRH signaling pathway_Homo sapiens_hsa049121.16308868
32Hippo signaling pathway_Homo sapiens_hsa043901.15504155
33Acute myeloid leukemia_Homo sapiens_hsa052211.14247461
34Salivary secretion_Homo sapiens_hsa049701.14143010
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13751449
36Adherens junction_Homo sapiens_hsa045201.09581093
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06937841
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.05544875
39Non-small cell lung cancer_Homo sapiens_hsa052231.03489873
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.02432063
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01833221
42Hedgehog signaling pathway_Homo sapiens_hsa043401.01477466
43Gap junction_Homo sapiens_hsa045401.01294979
44Melanogenesis_Homo sapiens_hsa049160.99567029
45Renin secretion_Homo sapiens_hsa049240.98911589
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97448641
47Fatty acid biosynthesis_Homo sapiens_hsa000610.97012205
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96137559
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95611574
50Prion diseases_Homo sapiens_hsa050200.94555922
51Chronic myeloid leukemia_Homo sapiens_hsa052200.94370113
52Shigellosis_Homo sapiens_hsa051310.94089052
53Osteoclast differentiation_Homo sapiens_hsa043800.93721874
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.93603673
55Fat digestion and absorption_Homo sapiens_hsa049750.93399629
56Endometrial cancer_Homo sapiens_hsa052130.92407576
57PPAR signaling pathway_Homo sapiens_hsa033200.90955763
58Galactose metabolism_Homo sapiens_hsa000520.89960750
59ErbB signaling pathway_Homo sapiens_hsa040120.89895281
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89826827
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.88874298
62mTOR signaling pathway_Homo sapiens_hsa041500.88698621
63Renal cell carcinoma_Homo sapiens_hsa052110.87817526
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.87622297
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87092505
66Long-term potentiation_Homo sapiens_hsa047200.86635291
67Small cell lung cancer_Homo sapiens_hsa052220.85867229
68Dilated cardiomyopathy_Homo sapiens_hsa054140.83921027
69Oxytocin signaling pathway_Homo sapiens_hsa049210.82007600
70Endocytosis_Homo sapiens_hsa041440.81902221
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81682515
72Pentose phosphate pathway_Homo sapiens_hsa000300.81436390
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.80908997
74Fructose and mannose metabolism_Homo sapiens_hsa000510.80698602
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79629002
76Amphetamine addiction_Homo sapiens_hsa050310.79501406
77Axon guidance_Homo sapiens_hsa043600.79445785
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79064254
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78933493
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.78763210
81Pancreatic secretion_Homo sapiens_hsa049720.78290785
82Circadian entrainment_Homo sapiens_hsa047130.77151915
83Rap1 signaling pathway_Homo sapiens_hsa040150.76946013
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76918036
85Basal cell carcinoma_Homo sapiens_hsa052170.76579280
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76154878
87TGF-beta signaling pathway_Homo sapiens_hsa043500.75371836
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74835386
89Lysosome_Homo sapiens_hsa041420.74706789
90Insulin signaling pathway_Homo sapiens_hsa049100.74440078
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73712624
92Insulin secretion_Homo sapiens_hsa049110.72515970
93Thyroid hormone synthesis_Homo sapiens_hsa049180.71511350
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71507703
95Inositol phosphate metabolism_Homo sapiens_hsa005620.71017566
96Dopaminergic synapse_Homo sapiens_hsa047280.69902902
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69734022
98Salmonella infection_Homo sapiens_hsa051320.69617557
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69474342
100Insulin resistance_Homo sapiens_hsa049310.68675208
101Cocaine addiction_Homo sapiens_hsa050300.68581702
102Malaria_Homo sapiens_hsa051440.68079577
103Toxoplasmosis_Homo sapiens_hsa051450.67341638
104cAMP signaling pathway_Homo sapiens_hsa040240.66468790
105Sulfur relay system_Homo sapiens_hsa041220.65355789
106Glycerolipid metabolism_Homo sapiens_hsa005610.64938262
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64728239
108Chemokine signaling pathway_Homo sapiens_hsa040620.64462370
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64444715
110Pertussis_Homo sapiens_hsa051330.63938180
111Cholinergic synapse_Homo sapiens_hsa047250.63729392
112Choline metabolism in cancer_Homo sapiens_hsa052310.62985375
113Collecting duct acid secretion_Homo sapiens_hsa049660.62843027
114Arginine biosynthesis_Homo sapiens_hsa002200.62038888
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60957765
116MAPK signaling pathway_Homo sapiens_hsa040100.60278570
117Vibrio cholerae infection_Homo sapiens_hsa051100.59080749
118Phagosome_Homo sapiens_hsa041450.58914071
119TNF signaling pathway_Homo sapiens_hsa046680.57637050
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57469224
121Prolactin signaling pathway_Homo sapiens_hsa049170.57250265
122Glucagon signaling pathway_Homo sapiens_hsa049220.56673525
123Thyroid cancer_Homo sapiens_hsa052160.56419644
124Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56037694
125Pancreatic cancer_Homo sapiens_hsa052120.55625814
126Type II diabetes mellitus_Homo sapiens_hsa049300.55028612
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.54633629
128Vitamin B6 metabolism_Homo sapiens_hsa007500.54546158
129B cell receptor signaling pathway_Homo sapiens_hsa046620.53690195
130AMPK signaling pathway_Homo sapiens_hsa041520.53414399
131Hepatitis C_Homo sapiens_hsa051600.52776247
132Ras signaling pathway_Homo sapiens_hsa040140.51351010
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51060328
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.50546192

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