GAPDHP66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of synaptic transmission, GABAergic (GO:0032229)4.64037407
2DNA double-strand break processing (GO:0000729)4.46929484
3cullin deneddylation (GO:0010388)4.23720685
4behavioral response to nicotine (GO:0035095)4.05347806
5protein deneddylation (GO:0000338)4.02873310
6DNA deamination (GO:0045006)4.02799215
7replication fork processing (GO:0031297)3.98456231
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.81721974
9respiratory chain complex IV assembly (GO:0008535)3.80331344
10negative regulation of DNA-dependent DNA replication (GO:2000104)3.78313307
11water-soluble vitamin biosynthetic process (GO:0042364)3.76519586
12chaperone-mediated protein transport (GO:0072321)3.70111457
13DNA strand renaturation (GO:0000733)3.62579545
14ATP synthesis coupled proton transport (GO:0015986)3.58850520
15energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58850520
16peptidyl-histidine modification (GO:0018202)3.58554574
17cerebral cortex radially oriented cell migration (GO:0021799)3.56566055
18negative regulation of astrocyte differentiation (GO:0048712)3.49724876
19response to pheromone (GO:0019236)3.49547304
20rRNA modification (GO:0000154)3.45526043
21regulation of cilium movement (GO:0003352)3.37940893
22C4-dicarboxylate transport (GO:0015740)3.36448723
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35717052
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35717052
25regulation of helicase activity (GO:0051095)3.32930725
26DNA damage response, detection of DNA damage (GO:0042769)3.23066345
27maturation of 5.8S rRNA (GO:0000460)3.22833506
28establishment of protein localization to mitochondrial membrane (GO:0090151)3.19905140
29negative regulation of JAK-STAT cascade (GO:0046426)3.14063516
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06132913
31RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06114004
32protein-cofactor linkage (GO:0018065)3.04583558
33protein neddylation (GO:0045116)3.04578714
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04106358
35cytochrome complex assembly (GO:0017004)3.03728446
36proteasome assembly (GO:0043248)3.02701025
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02471981
38pseudouridine synthesis (GO:0001522)3.00043896
39recombinational repair (GO:0000725)2.96983078
40mitochondrial respiratory chain complex I assembly (GO:0032981)2.94300621
41NADH dehydrogenase complex assembly (GO:0010257)2.94300621
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94300621
43double-strand break repair via homologous recombination (GO:0000724)2.93827817
44DNA catabolic process, exonucleolytic (GO:0000738)2.90961002
45protein complex biogenesis (GO:0070271)2.90021404
46transcription elongation from RNA polymerase III promoter (GO:0006385)2.83929219
47termination of RNA polymerase III transcription (GO:0006386)2.83929219
48axoneme assembly (GO:0035082)2.80849299
49rRNA methylation (GO:0031167)2.80464564
50L-fucose metabolic process (GO:0042354)2.78042116
51L-fucose catabolic process (GO:0042355)2.78042116
52fucose catabolic process (GO:0019317)2.78042116
53gamma-aminobutyric acid transport (GO:0015812)2.77927982
54regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73878506
55platelet dense granule organization (GO:0060155)2.71195352
56chromatin remodeling at centromere (GO:0031055)2.71132677
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71085339
58negative regulation of protein localization to cell surface (GO:2000009)2.70628142
59CENP-A containing nucleosome assembly (GO:0034080)2.69609601
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.66852003
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.66852003
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.66852003
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.66829696
64regulation of mitotic spindle checkpoint (GO:1903504)2.66829696
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.66783601
66oxidative demethylation (GO:0070989)2.66200753
67regulation of action potential (GO:0098900)2.65152241
68DNA demethylation (GO:0080111)2.63945615
69cell migration in hindbrain (GO:0021535)2.63646062
70tRNA processing (GO:0008033)2.63451963
71regulation of nuclear cell cycle DNA replication (GO:0033262)2.63347865
72mitochondrial respiratory chain complex assembly (GO:0033108)2.63061345
73negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.62730893
74piRNA metabolic process (GO:0034587)2.62684522
75indolalkylamine metabolic process (GO:0006586)2.62046905
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62009672
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62009672
78mannosylation (GO:0097502)2.60674976
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.58914169
80negative regulation of DNA recombination (GO:0045910)2.58468154
81tachykinin receptor signaling pathway (GO:0007217)2.55609837
82regulation of timing of cell differentiation (GO:0048505)2.55352169
83protein polyglutamylation (GO:0018095)2.53937407
84regulation of collateral sprouting (GO:0048670)2.53337455
85intracellular protein transmembrane import (GO:0044743)2.53096884
86signal transduction involved in cell cycle checkpoint (GO:0072395)2.52363068
87tryptophan metabolic process (GO:0006568)2.51930078
88negative regulation of mast cell activation (GO:0033004)2.51826212
89signal peptide processing (GO:0006465)2.51593074
90retinal cone cell development (GO:0046549)2.51492578
91regulation of telomere maintenance (GO:0032204)2.51344109
92regulation of cellular amino acid metabolic process (GO:0006521)2.50776614
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50729587
94tryptophan catabolic process (GO:0006569)2.50285914
95indole-containing compound catabolic process (GO:0042436)2.50285914
96indolalkylamine catabolic process (GO:0046218)2.50285914
97negative regulation of telomere maintenance (GO:0032205)2.49098968
98regulation of meiosis I (GO:0060631)2.48328893
99cilium morphogenesis (GO:0060271)2.47875262
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.45467762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10593825
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.52290793
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.46943791
4ZNF274_21170338_ChIP-Seq_K562_Hela3.43421886
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.06361343
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98602331
7VDR_22108803_ChIP-Seq_LS180_Human2.89389828
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.69850459
9IGF1R_20145208_ChIP-Seq_DFB_Human2.66158304
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60825238
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.40720272
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.27732420
13EWS_26573619_Chip-Seq_HEK293_Human2.24507366
14FUS_26573619_Chip-Seq_HEK293_Human2.19406785
15GBX2_23144817_ChIP-Seq_PC3_Human2.19375505
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15893359
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.15822319
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13027458
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00608538
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.99923453
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99873713
22VDR_23849224_ChIP-Seq_CD4+_Human1.93945008
23ELK1_19687146_ChIP-ChIP_HELA_Human1.93616899
24P300_19829295_ChIP-Seq_ESCs_Human1.91322452
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.90578921
26EZH2_22144423_ChIP-Seq_EOC_Human1.87408800
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86281675
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82231290
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80166090
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78508754
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73591123
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60431760
33FOXP3_21729870_ChIP-Seq_TREG_Human1.57498233
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53366187
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.50202915
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50061869
37CBP_20019798_ChIP-Seq_JUKART_Human1.49096539
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49096539
39IRF1_19129219_ChIP-ChIP_H3396_Human1.45099094
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.44545360
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41061670
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34677458
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34179059
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32998818
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32073438
46ER_23166858_ChIP-Seq_MCF-7_Human1.32018500
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30832145
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29989417
49UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29906723
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29820134
51MYC_18940864_ChIP-ChIP_HL60_Human1.29765052
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28671996
53TAF15_26573619_Chip-Seq_HEK293_Human1.26401083
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26288297
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.26125941
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.24344777
57TP53_22573176_ChIP-Seq_HFKS_Human1.23540301
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23472057
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22683540
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20153646
61SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19988697
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18811470
63TCF4_22108803_ChIP-Seq_LS180_Human1.18791533
64SOX2_19829295_ChIP-Seq_ESCs_Human1.17650157
65NANOG_19829295_ChIP-Seq_ESCs_Human1.17650157
66AR_25329375_ChIP-Seq_VCAP_Human1.16740692
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.15239982
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15200117
69TCF4_23295773_ChIP-Seq_U87_Human1.14953253
70BCAT_22108803_ChIP-Seq_LS180_Human1.14528041
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14190579
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13662299
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.13662299
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.12321809
75GABP_19822575_ChIP-Seq_HepG2_Human1.08019390
76SMAD4_21799915_ChIP-Seq_A2780_Human1.07776306
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07520662
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07167498
79NCOR_22424771_ChIP-Seq_293T_Human1.06215919
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06070368
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06070368
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.05465299
83RUNX2_22187159_ChIP-Seq_PCA_Human1.03805537
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03513904
85STAT3_23295773_ChIP-Seq_U87_Human1.02283774
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00349565
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98710086
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98335131
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95011492
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93455853
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93330680
92REST_21632747_ChIP-Seq_MESCs_Mouse0.92699258
93THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90832612
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90475577
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88940950
96PIAS1_25552417_ChIP-Seq_VCAP_Human0.88893474
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88468931
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.88303585
99HOXB7_26014856_ChIP-Seq_BT474_Human0.87562954
100P53_22387025_ChIP-Seq_ESCs_Mouse0.87236887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.17541811
2MP0000372_irregular_coat_pigmentation3.20483689
3MP0008877_abnormal_DNA_methylation2.93487865
4MP0008789_abnormal_olfactory_epithelium2.48339051
5MP0005551_abnormal_eye_electrophysiolog2.48157581
6MP0005408_hypopigmentation2.44682642
7MP0004147_increased_porphyrin_level2.36804033
8MP0001968_abnormal_touch/_nociception2.31605363
9MP0008058_abnormal_DNA_repair2.22409159
10MP0002736_abnormal_nociception_after2.17554276
11MP0003195_calcinosis2.04341337
12MP0003693_abnormal_embryo_hatching2.00747282
13MP0001293_anophthalmia1.99275251
14MP0002102_abnormal_ear_morphology1.98673842
15MP0002938_white_spotting1.95887071
16MP0002234_abnormal_pharynx_morphology1.89440691
17MP0004270_analgesia1.89230431
18MP0000427_abnormal_hair_cycle1.88621355
19MP0004885_abnormal_endolymph1.87934972
20MP0006072_abnormal_retinal_apoptosis1.84180143
21MP0003136_yellow_coat_color1.82066549
22MP0005075_abnormal_melanosome_morpholog1.80856504
23MP0005394_taste/olfaction_phenotype1.78480400
24MP0005499_abnormal_olfactory_system1.78480400
25MP0010094_abnormal_chromosome_stability1.76716367
26MP0001984_abnormal_olfaction1.71655784
27MP0003718_maternal_effect1.69755106
28MP0009745_abnormal_behavioral_response1.69502605
29MP0002837_dystrophic_cardiac_calcinosis1.64353750
30MP0000631_abnormal_neuroendocrine_gland1.63910221
31MP0001529_abnormal_vocalization1.63473899
32MP0002751_abnormal_autonomic_nervous1.57405178
33MP0002095_abnormal_skin_pigmentation1.52304095
34MP0002272_abnormal_nervous_system1.48535352
35MP0005253_abnormal_eye_physiology1.46991240
36MP0004145_abnormal_muscle_electrophysio1.46063273
37MP0004381_abnormal_hair_follicle1.45790959
38MP0003011_delayed_dark_adaptation1.43284623
39MP0003880_abnormal_central_pattern1.41438238
40MP0008057_abnormal_DNA_replication1.39072133
41MP0004742_abnormal_vestibular_system1.35119781
42MP0003786_premature_aging1.33576097
43MP0002163_abnormal_gland_morphology1.30007572
44MP0002822_catalepsy1.29278056
45MP0002735_abnormal_chemical_nociception1.28720335
46MP0006035_abnormal_mitochondrial_morpho1.28304156
47MP0002734_abnormal_mechanical_nocicepti1.26698159
48MP0004133_heterotaxia1.26516563
49MP0004142_abnormal_muscle_tone1.25761253
50MP0000647_abnormal_sebaceous_gland1.24169994
51MP0003787_abnormal_imprinting1.24074666
52MP0003646_muscle_fatigue1.23551368
53MP0001986_abnormal_taste_sensitivity1.22982635
54MP0001486_abnormal_startle_reflex1.20344298
55MP0008872_abnormal_physiological_respon1.19349565
56MP0006276_abnormal_autonomic_nervous1.19251614
57MP0001177_atelectasis1.16869203
58MP0003186_abnormal_redox_activity1.16138477
59MP0002572_abnormal_emotion/affect_behav1.15053133
60MP0003121_genomic_imprinting1.14739240
61MP0001501_abnormal_sleep_pattern1.11391922
62MP0003635_abnormal_synaptic_transmissio1.11240552
63MP0002653_abnormal_ependyma_morphology1.10549367
64MP0002733_abnormal_thermal_nociception1.06498403
65MP0003122_maternal_imprinting1.03133993
66MP0001485_abnormal_pinna_reflex1.01945258
67MP0005379_endocrine/exocrine_gland_phen0.99914278
68MP0008875_abnormal_xenobiotic_pharmacok0.98502125
69MP0005451_abnormal_body_composition0.98171838
70MP0005195_abnormal_posterior_eye0.98154769
71MP0002752_abnormal_somatic_nervous0.97108900
72MP0000778_abnormal_nervous_system0.96737782
73MP0009046_muscle_twitch0.96165896
74MP0001970_abnormal_pain_threshold0.93141545
75MP0006036_abnormal_mitochondrial_physio0.90582528
76MP0001764_abnormal_homeostasis0.90285707
77MP0000569_abnormal_digit_pigmentation0.89273766
78MP0005646_abnormal_pituitary_gland0.88725963
79MP0002067_abnormal_sensory_capabilities0.88603927
80MP0002064_seizures0.88232648
81MP0005391_vision/eye_phenotype0.87871998
82MP0002638_abnormal_pupillary_reflex0.86590257
83MP0002557_abnormal_social/conspecific_i0.86461299
84MP0002233_abnormal_nose_morphology0.81337752
85MP0005310_abnormal_salivary_gland0.79059339
86MP0003878_abnormal_ear_physiology0.78398400
87MP0005377_hearing/vestibular/ear_phenot0.78398400
88MP0004957_abnormal_blastocyst_morpholog0.77542513
89MP0003937_abnormal_limbs/digits/tail_de0.76851757
90MP0005174_abnormal_tail_pigmentation0.75864686
91MP0002138_abnormal_hepatobiliary_system0.74509500
92MP0002063_abnormal_learning/memory/cond0.74392553
93MP0005389_reproductive_system_phenotype0.74310038
94MP0000026_abnormal_inner_ear0.74111601
95MP0002098_abnormal_vibrissa_morphology0.73920963
96MP0008995_early_reproductive_senescence0.73905427
97MP0000358_abnormal_cell_content/0.72967402
98MP0002184_abnormal_innervation0.72769140
99MP0000049_abnormal_middle_ear0.71954464
100MP0005084_abnormal_gallbladder_morpholo0.71334043

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)3.94947145
2True hermaphroditism (HP:0010459)3.81626461
3Pancreatic fibrosis (HP:0100732)3.78078846
4Congenital stationary night blindness (HP:0007642)3.73441212
5Abnormality of the labia minora (HP:0012880)3.44576673
6Colon cancer (HP:0003003)3.40922755
7Abnormality of midbrain morphology (HP:0002418)3.32735410
8Molar tooth sign on MRI (HP:0002419)3.32735410
9Adrenal hypoplasia (HP:0000835)3.10343716
10Medial flaring of the eyebrow (HP:0010747)3.08481374
11Increased CSF lactate (HP:0002490)3.04579370
12Chronic hepatic failure (HP:0100626)2.99562984
13Acute necrotizing encephalopathy (HP:0006965)2.95663850
14Congenital, generalized hypertrichosis (HP:0004540)2.93520579
15Mitochondrial inheritance (HP:0001427)2.93404848
16Abnormality of the renal medulla (HP:0100957)2.89610328
17Nephronophthisis (HP:0000090)2.85552840
18Abnormality of the renal cortex (HP:0011035)2.85321209
19Methylmalonic acidemia (HP:0002912)2.85133309
20Acute encephalopathy (HP:0006846)2.83269166
21Gait imbalance (HP:0002141)2.78222983
22Pendular nystagmus (HP:0012043)2.77241623
23Congenital primary aphakia (HP:0007707)2.68519974
24Abnormal biliary tract physiology (HP:0012439)2.64533881
25Bile duct proliferation (HP:0001408)2.64533881
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.63650343
27Hepatocellular necrosis (HP:0001404)2.60385922
28Progressive macrocephaly (HP:0004481)2.56228024
29Increased hepatocellular lipid droplets (HP:0006565)2.49943129
30Cystic liver disease (HP:0006706)2.49507764
31Broad-based gait (HP:0002136)2.49323581
32Nephrogenic diabetes insipidus (HP:0009806)2.46882547
33Increased serum lactate (HP:0002151)2.44156754
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.44122670
35Abnormality of alanine metabolism (HP:0010916)2.44122670
36Hyperalaninemia (HP:0003348)2.44122670
37Renal cortical cysts (HP:0000803)2.43548233
38Abnormal mitochondria in muscle tissue (HP:0008316)2.42430308
39Lipid accumulation in hepatocytes (HP:0006561)2.37953963
40Optic disc pallor (HP:0000543)2.37628753
41Progressive inability to walk (HP:0002505)2.34189539
42Hyperventilation (HP:0002883)2.30554967
43Hepatic necrosis (HP:0002605)2.29593983
44Thyroid-stimulating hormone excess (HP:0002925)2.25835005
45Genital tract atresia (HP:0001827)2.25604639
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.24540413
47Vaginal atresia (HP:0000148)2.20337570
48Gaze-evoked nystagmus (HP:0000640)2.17906012
49Methylmalonic aciduria (HP:0012120)2.13993374
50Abnormality of the metopic suture (HP:0005556)2.13873119
51Anencephaly (HP:0002323)2.13828223
52Oligodactyly (hands) (HP:0001180)2.13735232
53Postaxial foot polydactyly (HP:0001830)2.13493972
54Type II lissencephaly (HP:0007260)2.12188008
55Abnormal rod and cone electroretinograms (HP:0008323)2.11641239
56Occipital encephalocele (HP:0002085)2.11055390
57Inability to walk (HP:0002540)2.08236062
58Abnormality of macular pigmentation (HP:0008002)2.08220070
59Sclerocornea (HP:0000647)2.05781715
60Attenuation of retinal blood vessels (HP:0007843)2.04634538
61Preaxial hand polydactyly (HP:0001177)2.04432924
62Lissencephaly (HP:0001339)2.04281941
63Increased corneal curvature (HP:0100692)2.03452864
64Keratoconus (HP:0000563)2.03452864
65Astigmatism (HP:0000483)1.99411650
66Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99399383
67Supernumerary spleens (HP:0009799)1.98253682
68Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92976857
69Dandy-Walker malformation (HP:0001305)1.92234659
70Male pseudohermaphroditism (HP:0000037)1.90065597
71Type 2 muscle fiber atrophy (HP:0003554)1.88044302
72Disproportionate short-trunk short stature (HP:0003521)1.87727506
73Abnormal lung lobation (HP:0002101)1.87103757
74Sloping forehead (HP:0000340)1.86356089
75Chorioretinal atrophy (HP:0000533)1.85761701
76Oligodactyly (HP:0012165)1.84904658
77Narrow forehead (HP:0000341)1.83255459
78Abolished electroretinogram (ERG) (HP:0000550)1.82635984
79Renal hypoplasia (HP:0000089)1.82278515
80Lactic acidosis (HP:0003128)1.81758452
81Meckel diverticulum (HP:0002245)1.81509112
82Abnormality of the ileum (HP:0001549)1.80643468
83Natal tooth (HP:0000695)1.80166810
84Hypomagnesemia (HP:0002917)1.77861707
85Pachygyria (HP:0001302)1.77808244
86Decreased central vision (HP:0007663)1.77338038
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.76935126
88Abnormality of serum amino acid levels (HP:0003112)1.76214230
89Abnormality of methionine metabolism (HP:0010901)1.74495270
90Optic nerve coloboma (HP:0000588)1.74474087
91Abnormality of glycolysis (HP:0004366)1.74079911
92Cerebral edema (HP:0002181)1.74034653
93Poor coordination (HP:0002370)1.73859100
94Postaxial hand polydactyly (HP:0001162)1.73812590
95Increased serum pyruvate (HP:0003542)1.73628281
96Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72324293
973-Methylglutaconic aciduria (HP:0003535)1.72250971
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.71685203
99Congenital hepatic fibrosis (HP:0002612)1.71655529
100Broad foot (HP:0001769)1.70143160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.43103733
2TNIK3.51140968
3VRK23.17613814
4TRIM283.07105275
5FRK2.93599234
6BUB12.44248000
7GRK12.35340025
8MST42.33942500
9NUAK12.26494970
10EIF2AK12.26470471
11NME12.19530068
12WNK32.09402408
13CASK2.06113866
14EIF2AK31.86467024
15TSSK61.67535203
16ADRBK21.66828777
17CSNK1G31.62234462
18PLK31.61236823
19BMPR1B1.60467095
20SRPK11.57728947
21ZAK1.56599800
22TAF11.54645248
23GRK51.53844765
24CSNK1G11.53193022
25CSNK1A1L1.51071077
26DYRK21.49172315
27MARK11.46486407
28MAPK131.41023291
29CSNK1G21.34936576
30PDK21.33622147
31MAP3K41.33571226
32VRK11.33137422
33PLK21.26618044
34MKNK21.25934964
35BCR1.25895634
36EPHA41.20850233
37TAOK31.19240428
38PNCK1.10713514
39STK161.09861957
40PHKG21.08154914
41PHKG11.08154914
42OXSR11.02211614
43CDC71.01474576
44CCNB10.95960760
45MKNK10.94569803
46WEE10.93310420
47PRKCG0.92900241
48PINK10.89374371
49PLK40.87198210
50INSRR0.84951417
51STK390.84761285
52DAPK10.81717143
53STK38L0.80489571
54TXK0.77303333
55EIF2AK20.75980061
56PLK10.72053109
57TLK10.71574428
58CSNK1A10.65780116
59MAP2K70.64869216
60WNK40.64189458
61DAPK20.63865137
62SIK30.63273297
63ADRBK10.62774946
64NEK10.62505448
65PAK30.59577641
66ATR0.59394850
67PRKCE0.59012853
68PBK0.57435601
69MAPKAPK50.56204513
70ACVR1B0.53736141
71BCKDK0.51156400
72BRSK20.50772279
73NEK20.49226762
74CHEK20.47003634
75TIE10.45036639
76TGFBR10.44318635
77PRKCI0.43846099
78EPHB20.43421072
79STK30.42742049
80CDK80.40589821
81ATM0.38115154
82CSNK2A10.37931351
83TTK0.37863827
84CSNK1E0.36290978
85MINK10.36094005
86MAP3K120.34803419
87CDK180.33908443
88ERBB30.33048545
89TNK20.32093682
90PRKACA0.31268144
91PRKD30.31134733
92CDK140.31063328
93CSNK1D0.29862829
94PRKDC0.29711934
95CDK50.28675455
96CHEK10.28096166
97CAMK2A0.28020874
98CSNK2A20.27802993
99CDK150.27785330
100AURKB0.27446251

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.87526923
2Homologous recombination_Homo sapiens_hsa034403.05383977
3Protein export_Homo sapiens_hsa030602.88438053
4Oxidative phosphorylation_Homo sapiens_hsa001902.69017439
5Non-homologous end-joining_Homo sapiens_hsa034502.63776201
6RNA polymerase_Homo sapiens_hsa030202.50496819
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31076977
8Parkinsons disease_Homo sapiens_hsa050122.29651098
9Mismatch repair_Homo sapiens_hsa034302.19341789
10Fanconi anemia pathway_Homo sapiens_hsa034602.15232034
11Phototransduction_Homo sapiens_hsa047442.14609688
12Basal transcription factors_Homo sapiens_hsa030222.03995426
13RNA degradation_Homo sapiens_hsa030182.00171932
14Nicotine addiction_Homo sapiens_hsa050331.96961071
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95875358
16Propanoate metabolism_Homo sapiens_hsa006401.88539585
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.75957804
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.68349577
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68017333
20Base excision repair_Homo sapiens_hsa034101.62475736
21Huntingtons disease_Homo sapiens_hsa050161.53054468
22One carbon pool by folate_Homo sapiens_hsa006701.45875590
23RNA transport_Homo sapiens_hsa030131.39258122
24Caffeine metabolism_Homo sapiens_hsa002321.35104811
25Pyrimidine metabolism_Homo sapiens_hsa002401.34959023
26Alzheimers disease_Homo sapiens_hsa050101.34689373
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31388107
28Selenocompound metabolism_Homo sapiens_hsa004501.28439675
29Purine metabolism_Homo sapiens_hsa002301.26777742
30Tryptophan metabolism_Homo sapiens_hsa003801.26696307
31Linoleic acid metabolism_Homo sapiens_hsa005911.24060557
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23243283
33DNA replication_Homo sapiens_hsa030301.22511065
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16786454
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16189665
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15259593
37Nitrogen metabolism_Homo sapiens_hsa009101.14141552
38Nucleotide excision repair_Homo sapiens_hsa034201.13451413
39Sulfur metabolism_Homo sapiens_hsa009201.12293184
40Fatty acid biosynthesis_Homo sapiens_hsa000611.11650861
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09750914
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08575139
43Peroxisome_Homo sapiens_hsa041461.08457723
44Steroid biosynthesis_Homo sapiens_hsa001001.07732175
45Spliceosome_Homo sapiens_hsa030401.07465958
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.03477377
47Taste transduction_Homo sapiens_hsa047421.02835720
48Ribosome_Homo sapiens_hsa030101.02116444
49Cardiac muscle contraction_Homo sapiens_hsa042600.98560639
50Butanoate metabolism_Homo sapiens_hsa006500.97514536
51Morphine addiction_Homo sapiens_hsa050320.96820762
52Folate biosynthesis_Homo sapiens_hsa007900.95128845
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92842997
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87945149
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83455097
56Chemical carcinogenesis_Homo sapiens_hsa052040.82833026
57Ether lipid metabolism_Homo sapiens_hsa005650.81704193
58Olfactory transduction_Homo sapiens_hsa047400.78684558
59Pyruvate metabolism_Homo sapiens_hsa006200.76241375
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75932641
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.75376775
62Vitamin B6 metabolism_Homo sapiens_hsa007500.75270176
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74935947
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74610066
65Glutamatergic synapse_Homo sapiens_hsa047240.74302745
66Fatty acid elongation_Homo sapiens_hsa000620.73307127
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72279528
68Metabolic pathways_Homo sapiens_hsa011000.72068017
69Glutathione metabolism_Homo sapiens_hsa004800.70948481
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68098296
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67647024
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67505957
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.67099551
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65073060
75Collecting duct acid secretion_Homo sapiens_hsa049660.64039715
76beta-Alanine metabolism_Homo sapiens_hsa004100.63488634
77Fatty acid degradation_Homo sapiens_hsa000710.62510347
78GABAergic synapse_Homo sapiens_hsa047270.60847465
79Fatty acid metabolism_Homo sapiens_hsa012120.58232583
80Regulation of autophagy_Homo sapiens_hsa041400.58092296
81Oocyte meiosis_Homo sapiens_hsa041140.56853651
82Retinol metabolism_Homo sapiens_hsa008300.51362974
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47293920
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.44170529
85Glycerolipid metabolism_Homo sapiens_hsa005610.43860521
86Arachidonic acid metabolism_Homo sapiens_hsa005900.43593361
87Biosynthesis of amino acids_Homo sapiens_hsa012300.42387533
88Asthma_Homo sapiens_hsa053100.41187972
89Dopaminergic synapse_Homo sapiens_hsa047280.41032515
90mRNA surveillance pathway_Homo sapiens_hsa030150.40658105
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40356886
92Primary immunodeficiency_Homo sapiens_hsa053400.38938009
93Serotonergic synapse_Homo sapiens_hsa047260.38654365
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.37781663
95Fat digestion and absorption_Homo sapiens_hsa049750.37037614
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36507047
97Amphetamine addiction_Homo sapiens_hsa050310.36282480
98Circadian entrainment_Homo sapiens_hsa047130.36246659
99Cell cycle_Homo sapiens_hsa041100.34601336
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34593024

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