GAPDHP39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T cell receptor signaling pathway (GO:0050860)9.92276909
2eosinophil migration (GO:0072677)9.50691654
3regulation of sister chromatid cohesion (GO:0007063)8.76374451
4regulation of mononuclear cell migration (GO:0071675)8.73508113
5negative regulation of peptidyl-threonine phosphorylation (GO:0010801)8.72173156
6L-fucose catabolic process (GO:0042355)8.09870627
7fucose catabolic process (GO:0019317)8.09870627
8L-fucose metabolic process (GO:0042354)8.09870627
9negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)7.77765454
10ribosomal small subunit assembly (GO:0000028)7.76271654
11branch elongation of an epithelium (GO:0060602)7.68791647
12vesicle fusion (GO:0006906)7.47743234
13negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)7.30705357
14positive regulation of chromosome segregation (GO:0051984)7.10582193
15peptidyl-lysine dimethylation (GO:0018027)6.89755547
16autophagic vacuole fusion (GO:0000046)6.76218039
17coenzyme A biosynthetic process (GO:0015937)6.61400354
18macrophage chemotaxis (GO:0048246)6.43872596
19organ growth (GO:0035265)5.96003107
20regulation of T cell receptor signaling pathway (GO:0050856)5.88061390
21localization within membrane (GO:0051668)5.79360136
22axis elongation (GO:0003401)5.68510188
23negative regulation of GTP catabolic process (GO:0033125)5.66641171
24negative regulation of GTPase activity (GO:0034260)5.66641171
25positive regulation of calcium ion import (GO:0090280)5.64823629
26regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.62811642
27establishment of mitotic spindle orientation (GO:0000132)5.62464989
28regulation of beta-amyloid formation (GO:1902003)5.52838826
29organelle membrane fusion (GO:0090174)5.51845041
30acrosome assembly (GO:0001675)5.28719139
31protein import into peroxisome matrix (GO:0016558)5.24004915
32monocyte chemotaxis (GO:0002548)5.23996445
33non-recombinational repair (GO:0000726)4.94050485
34double-strand break repair via nonhomologous end joining (GO:0006303)4.94050485
35establishment of mitotic spindle localization (GO:0040001)4.90105659
36protein targeting to vacuole (GO:0006623)4.86586364
37protein targeting to lysosome (GO:0006622)4.86586364
38establishment of protein localization to vacuole (GO:0072666)4.86586364
39establishment of spindle orientation (GO:0051294)4.79069803
40oxidative demethylation (GO:0070989)4.78200695
41detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.70729894
42negative regulation of circadian rhythm (GO:0042754)4.69419075
433-UTR-mediated mRNA stabilization (GO:0070935)4.59067363
44organelle fusion (GO:0048284)4.56021685
45histone H3-K9 methylation (GO:0051567)4.51221438
46regulation of stem cell maintenance (GO:2000036)4.49758953
47pantothenate metabolic process (GO:0015939)4.49616223
48fucosylation (GO:0036065)4.41914055
49regulation of amyloid precursor protein catabolic process (GO:1902991)4.41208072
50positive chemotaxis (GO:0050918)4.40481350
51seminiferous tubule development (GO:0072520)4.39214323
52fucose metabolic process (GO:0006004)4.30884915
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.30535136
54regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.26187458
55regulation of autophagic vacuole assembly (GO:2000785)4.18968042
56ribonucleoside bisphosphate biosynthetic process (GO:0034030)4.10881090
57nucleoside bisphosphate biosynthetic process (GO:0033866)4.10881090
58purine nucleoside bisphosphate biosynthetic process (GO:0034033)4.10881090
59detection of chemical stimulus involved in sensory perception of taste (GO:0050912)4.08029533
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.00484483
61coenzyme A metabolic process (GO:0015936)3.95763413
62preassembly of GPI anchor in ER membrane (GO:0016254)3.86099547
63mitochondrial RNA metabolic process (GO:0000959)3.85774982
64single-organism membrane fusion (GO:0044801)3.81981908
65negative regulation of purine nucleotide catabolic process (GO:0033122)3.80382219
66regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.77327825
67protein localization to lysosome (GO:0061462)3.75535114
68protein localization to vacuole (GO:0072665)3.75535114
69folic acid-containing compound biosynthetic process (GO:0009396)3.70438862
70histone H3-K9 modification (GO:0061647)3.69676965
71ER to Golgi vesicle-mediated transport (GO:0006888)3.66309700
72negative regulation of nucleoside metabolic process (GO:0045978)3.64690068
73negative regulation of nucleotide catabolic process (GO:0030812)3.59722095
74vesicle targeting (GO:0006903)3.47463425
75negative regulation of macroautophagy (GO:0016242)3.47263482
76regulation of vacuole organization (GO:0044088)3.44040357
77DNA integration (GO:0015074)3.43794153
78COPII vesicle coating (GO:0048208)3.42506597
79regulation of mammary gland epithelial cell proliferation (GO:0033599)3.41529206
80regulation of cellular amide metabolic process (GO:0034248)3.41436189
81establishment of spindle localization (GO:0051293)3.41276057
82protein targeting to peroxisome (GO:0006625)3.41205581
83establishment of protein localization to peroxisome (GO:0072663)3.41205581
84protein localization to peroxisome (GO:0072662)3.41205581
85DNA demethylation (GO:0080111)3.38601901
86regulation of calcium ion import (GO:0090279)3.36509390
87sodium-independent organic anion transport (GO:0043252)3.34697986
88membrane budding (GO:0006900)3.30518758
89proteasome assembly (GO:0043248)3.30513384
90peroxisomal transport (GO:0043574)3.28851822
91regulation of peptidyl-threonine phosphorylation (GO:0010799)3.24403590
92imidazole-containing compound metabolic process (GO:0052803)3.21157672
93early endosome to late endosome transport (GO:0045022)3.20559304
94negative regulation of Ras GTPase activity (GO:0034261)12.3799359
95prenylation (GO:0097354)12.2603047
96protein prenylation (GO:0018342)12.2603047
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)11.4091837
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)11.4091837
99positive regulation of mitotic sister chromatid separation (GO:1901970)11.4091837
100eosinophil chemotaxis (GO:0048245)10.4906568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human6.18102570
2NOTCH1_21737748_ChIP-Seq_TLL_Human4.31671518
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.17807772
4AR_21572438_ChIP-Seq_LNCaP_Human2.99438988
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.65952760
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57018592
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.55599841
8ZNF263_19887448_ChIP-Seq_K562_Human2.45854523
9SRY_22984422_ChIP-ChIP_TESTIS_Rat2.31053450
10YY1_21170310_ChIP-Seq_MESCs_Mouse2.09227436
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08462147
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse10.5082144
13GATA1_22025678_ChIP-Seq_K562_Human10.2329879
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.94807485
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81448116
16PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.81361574
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74650617
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71418679
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.71418679
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.66541380
21BCAT_22108803_ChIP-Seq_LS180_Human1.64911699
22IRF1_19129219_ChIP-ChIP_H3396_Human1.63187317
23RXR_22108803_ChIP-Seq_LS180_Human1.58466972
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.50787845
25P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44697850
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43981743
27GATA3_26560356_Chip-Seq_TH1_Human1.43681002
28TAF15_26573619_Chip-Seq_HEK293_Human1.40849584
29ZNF274_21170338_ChIP-Seq_K562_Hela1.38391846
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37488749
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.36043395
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34892322
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.26477502
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26147168
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24323682
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24323682
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24323682
38TP53_16413492_ChIP-PET_HCT116_Human1.23390933
39GBX2_23144817_ChIP-Seq_PC3_Human1.15885353
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15406079
41TP53_22573176_ChIP-Seq_HFKS_Human1.05999573
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05574278
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03493611
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02763446
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.02753012
46RUNX_20019798_ChIP-Seq_JUKART_Human1.02648132
47ETS1_20019798_ChIP-Seq_JURKAT_Human0.97392326
48CTBP1_25329375_ChIP-Seq_LNCAP_Human0.96719836
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.93465918
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90441899
51CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89570732
52STAT1_20625510_ChIP-Seq_HELA_Human0.88934368
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88320406
54FUS_26573619_Chip-Seq_HEK293_Human0.86492792
55FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85922160
56FOXA1_25329375_ChIP-Seq_VCAP_Human0.85922160
57FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85218053
58WDR5_24793694_ChIP-Seq_LNCAP_Human0.84440139
59TCF4_22108803_ChIP-Seq_LS180_Human0.79974220
60CTCF_21964334_Chip-Seq_Bcells_Human0.78098229
61P300_19829295_ChIP-Seq_ESCs_Human0.77070850
62FOXH1_21741376_ChIP-Seq_ESCs_Human0.75803738
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74313261
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.74303326
65EGR1_23403033_ChIP-Seq_LIVER_Mouse0.73728640
66GATA1_19941826_ChIP-Seq_K562_Human0.72595097
67CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.72590124
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.72056735
69JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71995812
70OCT1_27270436_Chip-Seq_PROSTATE_Human0.70504379
71REST_18959480_ChIP-ChIP_MESCs_Mouse0.70312221
72NANOG_19829295_ChIP-Seq_ESCs_Human0.69693116
73SOX2_19829295_ChIP-Seq_ESCs_Human0.69693116
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.68432427
75GATA3_21867929_ChIP-Seq_TH1_Mouse0.68093828
76SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.67067415
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.66071663
78ERG_20517297_ChIP-Seq_VCAP_Human0.65080728
79TBX3_20139965_ChIP-Seq_ESCs_Mouse0.65066583
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.64695663
81TBX3_20139965_ChIP-Seq_MESCs_Mouse0.64446492
82KLF5_20875108_ChIP-Seq_MESCs_Mouse0.63143975
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.62547735
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.61581494
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.61559023
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.60847258
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.60216621
88VDR_23849224_ChIP-Seq_CD4+_Human0.59842592
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.59435121
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.59342102
91CBP_20019798_ChIP-Seq_JUKART_Human0.59342102
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59256346
93HTT_18923047_ChIP-ChIP_STHdh_Human0.58677571
94NANOG_20526341_ChIP-Seq_ESCs_Human0.58338008
95KAP1_22055183_ChIP-Seq_ESCs_Mouse0.57966865
96ELF1_17652178_ChIP-ChIP_JURKAT_Human0.57390009
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.56063795
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.55281440
99MYC_18555785_ChIP-Seq_MESCs_Mouse0.55220792
100CBP_21632823_ChIP-Seq_H3396_Human0.54433061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation9.42810050
2MP0006082_CNS_inflammation5.53726540
3MP0001663_abnormal_digestive_system3.19552285
4MP0000467_abnormal_esophagus_morphology3.00522651
5MP0001664_abnormal_digestion2.98252349
6MP0001919_abnormal_reproductive_system2.74242390
7MP0000383_abnormal_hair_follicle2.51606469
8MP0002751_abnormal_autonomic_nervous2.36156405
9MP0005381_digestive/alimentary_phenotyp2.36047254
10MP0003115_abnormal_respiratory_system2.28970036
11MP0000566_synostosis12.5723426
12MP0002876_abnormal_thyroid_physiology1.99963945
13MP0005389_reproductive_system_phenotype1.69748849
14MP0005166_decreased_susceptibility_to1.67057653
15MP0010678_abnormal_skin_adnexa1.61782902
16MP0000534_abnormal_ureter_morphology1.56159261
17MP0003937_abnormal_limbs/digits/tail_de1.53389789
18MP0003136_yellow_coat_color1.27676750
19MP0001915_intracranial_hemorrhage1.21453893
20MP0005076_abnormal_cell_differentiation1.19298959
21MP0000428_abnormal_craniofacial_morphol1.14071848
22MP0001764_abnormal_homeostasis1.13630738
23MP0003453_abnormal_keratinocyte_physiol1.10596307
24MP0001293_anophthalmia1.06344544
25MP0003763_abnormal_thymus_physiology1.06284828
26MP0001545_abnormal_hematopoietic_system1.03870152
27MP0005397_hematopoietic_system_phenotyp1.03870152
28MP0001286_abnormal_eye_development1.03480017
29MP0000858_altered_metastatic_potential0.99363287
30MP0005501_abnormal_skin_physiology0.99301570
31MP0002019_abnormal_tumor_incidence0.93244493
32MP0002138_abnormal_hepatobiliary_system0.87023586
33MP0000026_abnormal_inner_ear0.86542013
34MP0002109_abnormal_limb_morphology0.86512555
35MP0001963_abnormal_hearing_physiology0.85671928
36MP0005360_urolithiasis0.83310099
37MP0005646_abnormal_pituitary_gland0.81927579
38MP0002938_white_spotting0.81625012
39MP0002638_abnormal_pupillary_reflex0.77433174
40MP0000358_abnormal_cell_content/0.76945887
41MP0008995_early_reproductive_senescence0.76731727
42MP0002405_respiratory_system_inflammati0.76529176
43MP0005253_abnormal_eye_physiology0.76390411
44MP0002115_abnormal_skeleton_extremities0.75984695
45MP0000490_abnormal_crypts_of0.75948190
46MP0009763_increased_sensitivity_to0.74990670
47MP0004885_abnormal_endolymph0.74627524
48MP0004381_abnormal_hair_follicle0.72821704
49MP0003195_calcinosis0.72548898
50MP0005075_abnormal_melanosome_morpholog0.72548044
51MP0010155_abnormal_intestine_physiology0.72485882
52MP0002736_abnormal_nociception_after0.71162399
53MP0000470_abnormal_stomach_morphology0.70010966
54MP0003329_amyloid_beta_deposits0.68780517
55MP0003942_abnormal_urinary_system0.68606716
56MP0002210_abnormal_sex_determination0.65668034
57MP0005197_abnormal_uvea_morphology0.65528092
58MP0002184_abnormal_innervation0.65407839
59MP0008872_abnormal_physiological_respon0.57336191
60MP0005332_abnormal_amino_acid0.55851182
61MP0003724_increased_susceptibility_to0.53542526
62MP0008058_abnormal_DNA_repair0.53248115
63MP0002735_abnormal_chemical_nociception0.52261303
64MP0005551_abnormal_eye_electrophysiolog0.50097367
65MP0001968_abnormal_touch/_nociception0.50011625
66MP0000377_abnormal_hair_follicle0.48202453
67MP0004145_abnormal_muscle_electrophysio0.48149386
68MP0005025_abnormal_response_to0.46899619
69MP0002095_abnormal_skin_pigmentation0.46615352
70MP0001800_abnormal_humoral_immune0.45771591
71MP0000477_abnormal_intestine_morphology0.45400878
72MP0001175_abnormal_lung_morphology0.43468721
73MP0005000_abnormal_immune_tolerance0.43316478
74MP0002452_abnormal_antigen_presenting0.42843372
75MP0000604_amyloidosis0.42420389
76MP0000432_abnormal_head_morphology0.41353172
77MP0003638_abnormal_response/metabolism_0.40380153
78MP0003936_abnormal_reproductive_system0.40347403
79MP0002136_abnormal_kidney_physiology0.40334415
80MP0005391_vision/eye_phenotype0.39295248
81MP0001501_abnormal_sleep_pattern0.39261591
82MP0000627_abnormal_mammary_gland0.38606826
83MP0005508_abnormal_skeleton_morphology0.38370748
84MP0006276_abnormal_autonomic_nervous0.38159184
85MP0000681_abnormal_thyroid_gland0.36863599
86MP0002163_abnormal_gland_morphology0.36770640
87MP0008875_abnormal_xenobiotic_pharmacok0.34832161
88MP0005671_abnormal_response_to0.33892757
89MP0003935_abnormal_craniofacial_develop0.33743195
90MP0003646_muscle_fatigue0.32959431
91MP0005023_abnormal_wound_healing0.32889791
92MP0004147_increased_porphyrin_level0.32864010
93MP0002752_abnormal_somatic_nervous0.32821600
94MP0000013_abnormal_adipose_tissue0.32712653
95MP0002113_abnormal_skeleton_development0.32003594
96MP0002837_dystrophic_cardiac_calcinosis0.31991051
97MP0003880_abnormal_central_pattern0.31863768
98MP0003011_delayed_dark_adaptation0.31257964
99MP0009672_abnormal_birth_weight0.30403251
100MP0001502_abnormal_circadian_rhythm0.29363847

Predicted human phenotypes

RankGene SetZ-score
1Duplicated collecting system (HP:0000081)9.36619402
2Abnormality of the renal collecting system (HP:0004742)8.44212280
3Long foot (HP:0001833)8.01008540
4Large for gestational age (HP:0001520)7.47318841
5Adactyly (HP:0009776)6.68015973
6Acute lymphatic leukemia (HP:0006721)6.60299536
7Progressive muscle weakness (HP:0003323)6.13628960
8Abnormality of fatty-acid metabolism (HP:0004359)6.01181882
9Hypoplastic pelvis (HP:0008839)5.90491043
10Dry hair (HP:0011359)5.31236582
11Autoamputation (HP:0001218)5.26709358
12Ureteral stenosis (HP:0000071)4.91203443
13Pulmonary artery stenosis (HP:0004415)4.90064726
14Brushfield spots (HP:0001088)4.80261030
15Steatorrhea (HP:0002570)4.78750069
16Ureteral duplication (HP:0000073)4.74361589
17Hypoplastic nipples (HP:0002557)4.64076891
18Menstrual irregularities (HP:0000858)4.61246240
19Ureteral obstruction (HP:0006000)4.51791186
20Reduced subcutaneous adipose tissue (HP:0003758)4.40048599
21Severe muscular hypotonia (HP:0006829)4.00920861
22Abnormal auditory evoked potentials (HP:0006958)3.96203026
23Sudden death (HP:0001699)3.77975953
24Fat malabsorption (HP:0002630)3.74463312
25Broad-based gait (HP:0002136)3.73740971
26Increased number of teeth (HP:0011069)3.66041730
27Anhidrosis (HP:0000970)3.65199904
28Transposition of the great arteries (HP:0001669)3.57849677
29Abnormal connection of the cardiac segments (HP:0011545)3.57849677
30Abnormal ventriculo-arterial connection (HP:0011563)3.57849677
31Decreased lacrimation (HP:0000633)3.57658198
32Polyneuropathy (HP:0001271)3.23318810
33Palmoplantar hyperkeratosis (HP:0000972)3.21046805
34Palmar hyperkeratosis (HP:0010765)3.02733276
35Decreased muscle mass (HP:0003199)3.01349244
36Abnormality of vision evoked potentials (HP:0000649)2.95030867
37Broad nasal tip (HP:0000455)2.92626636
38Polymicrogyria (HP:0002126)2.88974134
39Wide intermamillary distance (HP:0006610)2.88016592
40Clubbing of toes (HP:0100760)2.84957400
41Hypoplastic iliac wings (HP:0002866)2.79305448
42Myoglobinuria (HP:0002913)2.72018379
43Rhabdomyolysis (HP:0003201)2.59072377
44Large hands (HP:0001176)2.53311076
45Plantar hyperkeratosis (HP:0007556)2.53009009
46Chorioretinal coloboma (HP:0000567)2.51183145
47Generalized amyotrophy (HP:0003700)2.47911117
48Widely spaced teeth (HP:0000687)2.47177862
49Steppage gait (HP:0003376)2.45620387
50Epiphyseal stippling (HP:0010655)2.41531349
51Basal ganglia calcification (HP:0002135)2.39841733
52Flat face (HP:0012368)2.31297697
53Aplasia/Hypoplasia of the nipples (HP:0006709)2.28143791
54Lactic acidosis (HP:0003128)2.17310842
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16891444
56Abnormality of alanine metabolism (HP:0010916)2.16891444
57Hyperalaninemia (HP:0003348)2.16891444
58Female pseudohermaphroditism (HP:0010458)2.15113561
59Overfolded helix (HP:0000396)2.09306718
60Thickened calvaria (HP:0002684)2.09047564
61Purpura (HP:0000979)2.04779183
62Anxiety (HP:0000739)2.03981047
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)11.4941292
64Primary adrenal insufficiency (HP:0008207)1.98896078
65Gangrene (HP:0100758)1.95373227
66Arterial thrombosis (HP:0004420)1.92695853
67Pulmonary embolism (HP:0002204)1.90924113
68Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.88177418
69Prenatal maternal abnormality (HP:0002686)1.86974616
70Absent toe (HP:0010760)1.86224487
71Abnormally folded helix (HP:0008544)1.86130967
72Thickened nuchal skin fold (HP:0000474)1.84517411
73Abnormal epiphyseal ossification (HP:0010656)1.83788538
74Metabolic acidosis (HP:0001942)1.82851241
75Congenital onset (HP:0003577)1.79947966
76Posterior embryotoxon (HP:0000627)1.79368613
77Constricted visual fields (HP:0001133)1.79239476
78External ear malformation (HP:0008572)1.75811391
79Spastic tetraplegia (HP:0002510)1.75444898
80Foot dorsiflexor weakness (HP:0009027)1.74756639
81Congenital sensorineural hearing impairment (HP:0008527)1.73191972
82Abnormality of the line of Schwalbe (HP:0008048)1.71749220
83Arthrogryposis multiplex congenita (HP:0002804)1.69649506
84Stereotypic behavior (HP:0000733)1.66129358
85Generalized muscle weakness (HP:0003324)1.63840402
86Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.61805469
87Hammertoe (HP:0001765)1.60635327
88Depressed nasal ridge (HP:0000457)1.60200700
89Abnormality of the epiphyses of the hand (HP:0005924)1.56788522
90Abnormality of the foot musculature (HP:0001436)1.56631729
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.53088333
92Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46000590
93Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.45448616
94Hypoplastic ilia (HP:0000946)1.44714114
95Increased serum lactate (HP:0002151)1.42278131
96Retinopathy (HP:0000488)1.41303168
97Thrombophlebitis (HP:0004418)1.40954084
98Scrotal hypoplasia (HP:0000046)1.40842765
99Decreased motor nerve conduction velocity (HP:0003431)1.38121475
100Congenital stationary night blindness (HP:0007642)1.38115289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.74398821
2TAOK25.33585681
3TAOK15.18337921
4MAP3K34.36489451
5MAP2K34.18268110
6MAP3K113.85855370
7JAK32.69583640
8MKNK211.4556585
9ABL21.83617144
10DYRK1A1.77325317
11MAP3K51.24283477
12MAP3K10.92539855
13SRPK10.91473952
14CHEK20.83288596
15PRKCQ0.61181225
16MAP3K80.56953942
17TIE10.39437349
18TXK0.37695390
19GRK10.34421572
20CSNK1A10.30491015
21WNK30.28234339
22MAP4K20.25558336
23TEC0.25434852
24ACVR1B0.24036076
25ADRBK20.23787745
26MAP4K10.21277713
27ITK0.19934747
28FRK0.17198962
29ABL10.16478641
30STK160.15865565
31INSRR0.14664901
32PDK20.14336417
33OBSCN0.13991740
34PIK3CG0.13101691
35IGF1R0.13026276
36PRKCD0.12960837
37NTRK20.10552826
38PRKD30.09467708
39ADRBK10.09213219
40TLK10.08856503
41CSNK2A20.08038898
42PIK3CA0.07877274
43CSNK1G10.07175601
44EPHA40.07138371
45BMPR1B0.06651974
46WNK40.06325762
47PRKCA0.05874887
48CCNB10.05504053
49IKBKB0.05251138
50VRK10.04742497
51SYK0.04479892
52MAPK130.04328644
53CSNK2A10.03870868
54GRK70.03837008
55NME10.03576412
56CSNK1E0.03371902
57MUSK0.02993137
58CSNK1G30.02438573
59PRKACA0.02077479
60BTK0.02055513
61FLT30.01299914
62KIT0.01009756
63PRKCB0.00315088
64NUAK10.00101041
65CAMK2A-0.0745924
66FGR-0.0711751
67NTRK3-0.0708883
68BMPR2-0.0671366
69LCK-0.0670313
70ERBB4-0.0667084
71MAP3K4-0.0632641
72CAMK1-0.0614514
73LYN-0.0610627
74ZAK-0.0603603
75OXSR1-0.0537930
76TNIK-0.0520012
77CSNK1G2-0.0489077
78CAMK2D-0.0435638
79TGFBR1-0.0418944
80PIM2-0.0393051
81CDK9-0.0381613
82SRC-0.0303843
83IKBKE-0.0301555
84AURKA-0.0291871
85FES-0.0265112
86MAPK15-0.0240007
87GRK6-0.0239950
88PRKCG-0.0166742
89SGK494-0.0158402
90SGK223-0.0158402
91SGK2-0.0156332
92TNK2-0.0155792
93TAF1-0.0148445
94EPHB2-0.0115203
95GRK5-0.0062333
96PRKCE-0.0059920
97MAPKAPK5-0.0051596
98PHKG2-0.0047149
99PHKG1-0.0047149
100RPS6KB2-0.0019176

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041307.93910210
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007706.39497786
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.67359006
4Taste transduction_Homo sapiens_hsa047423.12024291
5RNA polymerase_Homo sapiens_hsa030202.88419063
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.74261947
7Proteasome_Homo sapiens_hsa030502.72922077
8One carbon pool by folate_Homo sapiens_hsa006702.67901338
9Butanoate metabolism_Homo sapiens_hsa006502.47114747
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.28339178
11Fatty acid elongation_Homo sapiens_hsa000622.08633933
12Lysine degradation_Homo sapiens_hsa003102.06361727
13beta-Alanine metabolism_Homo sapiens_hsa004101.90949397
14Propanoate metabolism_Homo sapiens_hsa006401.81811298
15Tryptophan metabolism_Homo sapiens_hsa003801.80077522
16Glycerolipid metabolism_Homo sapiens_hsa005611.76489229
17Amoebiasis_Homo sapiens_hsa051461.35478158
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.10460107
19Peroxisome_Homo sapiens_hsa041461.05701043
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.02780390
21Nitrogen metabolism_Homo sapiens_hsa009100.94635359
22Fatty acid degradation_Homo sapiens_hsa000710.93030288
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92850837
24Asthma_Homo sapiens_hsa053100.91582586
25Type I diabetes mellitus_Homo sapiens_hsa049400.88991293
26Allograft rejection_Homo sapiens_hsa053300.88118832
27Linoleic acid metabolism_Homo sapiens_hsa005910.82504413
28Nicotine addiction_Homo sapiens_hsa050330.81776465
29Complement and coagulation cascades_Homo sapiens_hsa046100.81731763
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81550401
31Viral myocarditis_Homo sapiens_hsa054160.80433048
32Intestinal immune network for IgA production_Homo sapiens_hsa046720.80154322
33Graft-versus-host disease_Homo sapiens_hsa053320.79916673
34Glycerophospholipid metabolism_Homo sapiens_hsa005640.79408552
35Steroid hormone biosynthesis_Homo sapiens_hsa001400.78471884
36Autoimmune thyroid disease_Homo sapiens_hsa053200.75999741
37Retinol metabolism_Homo sapiens_hsa008300.74808890
38Caffeine metabolism_Homo sapiens_hsa002320.70670483
39Olfactory transduction_Homo sapiens_hsa047400.68506322
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67871495
41Phototransduction_Homo sapiens_hsa047440.67005640
42Rheumatoid arthritis_Homo sapiens_hsa053230.66199049
43Primary immunodeficiency_Homo sapiens_hsa053400.65696246
44Hematopoietic cell lineage_Homo sapiens_hsa046400.65567574
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63996569
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63801921
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63063261
48Epstein-Barr virus infection_Homo sapiens_hsa051690.61237630
49Cholinergic synapse_Homo sapiens_hsa047250.59667478
50Fatty acid metabolism_Homo sapiens_hsa012120.57336462
51Pyrimidine metabolism_Homo sapiens_hsa002400.57110089
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56000031
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55920197
54Vitamin digestion and absorption_Homo sapiens_hsa049770.53524669
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51271668
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50075880
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48788522
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48085667
59Collecting duct acid secretion_Homo sapiens_hsa049660.47737448
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47074166
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46916130
62Arginine biosynthesis_Homo sapiens_hsa002200.46529699
63AMPK signaling pathway_Homo sapiens_hsa041520.43750929
64Serotonergic synapse_Homo sapiens_hsa047260.43462472
65Chemical carcinogenesis_Homo sapiens_hsa052040.41034810
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40378790
67Nucleotide excision repair_Homo sapiens_hsa034200.40276484
68Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40265185
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39119181
70Arachidonic acid metabolism_Homo sapiens_hsa005900.37768455
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.36158746
72Purine metabolism_Homo sapiens_hsa002300.35332205
73Sulfur metabolism_Homo sapiens_hsa009200.34653001
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34651648
75Systemic lupus erythematosus_Homo sapiens_hsa053220.31260975
76Morphine addiction_Homo sapiens_hsa050320.30256896
77Ether lipid metabolism_Homo sapiens_hsa005650.29504206
78RNA transport_Homo sapiens_hsa030130.28592409
79Metabolic pathways_Homo sapiens_hsa011000.28514630
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28466581
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28181254
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26657912
83Antigen processing and presentation_Homo sapiens_hsa046120.26430646
84Fat digestion and absorption_Homo sapiens_hsa049750.26185121
85TNF signaling pathway_Homo sapiens_hsa046680.26074121
86Choline metabolism in cancer_Homo sapiens_hsa052310.24748015
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22526919
88GABAergic synapse_Homo sapiens_hsa047270.19690686
89GnRH signaling pathway_Homo sapiens_hsa049120.18507304
90Phagosome_Homo sapiens_hsa041450.18342696
91MicroRNAs in cancer_Homo sapiens_hsa052060.17454463
92Salmonella infection_Homo sapiens_hsa051320.16225895
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16133491
94Tyrosine metabolism_Homo sapiens_hsa003500.15719172
95Ovarian steroidogenesis_Homo sapiens_hsa049130.15492009
96African trypanosomiasis_Homo sapiens_hsa051430.15123075
97Dopaminergic synapse_Homo sapiens_hsa047280.14917049
98Staphylococcus aureus infection_Homo sapiens_hsa051500.14731954
99Huntingtons disease_Homo sapiens_hsa050160.13527104
100Phenylalanine metabolism_Homo sapiens_hsa003600.12977355

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